-- dump date 20140619_073516 -- class Genbank::misc_feature -- table misc_feature_note -- id note 718254000001 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 718254000002 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 718254000003 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 718254000004 GTP binding site; other site 718254000005 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 718254000006 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 718254000007 serine/threonine protein kinase; Provisional; Region: PRK11768 718254000008 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 718254000009 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 718254000010 catalytic residues [active] 718254000011 hinge region; other site 718254000012 alpha helical domain; other site 718254000013 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718254000014 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 718254000015 putative acyl-acceptor binding pocket; other site 718254000016 Der GTPase activator; Provisional; Region: PRK05244 718254000017 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 718254000018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254000019 FeS/SAM binding site; other site 718254000020 HemN C-terminal domain; Region: HemN_C; pfam06969 718254000021 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 718254000022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 718254000023 putative active site [active] 718254000024 heme pocket [chemical binding]; other site 718254000025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254000026 dimer interface [polypeptide binding]; other site 718254000027 phosphorylation site [posttranslational modification] 718254000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254000029 ATP binding site [chemical binding]; other site 718254000030 Mg2+ binding site [ion binding]; other site 718254000031 G-X-G motif; other site 718254000032 glutamine synthetase; Provisional; Region: glnA; PRK09469 718254000033 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 718254000034 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 718254000035 outer membrane porin L; Provisional; Region: ompL; PRK09980 718254000036 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 718254000037 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 718254000038 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 718254000039 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 718254000040 alpha-glucosidase; Provisional; Region: PRK10426 718254000041 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 718254000042 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 718254000043 putative active site [active] 718254000044 putative catalytic site [active] 718254000045 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 718254000046 dimerization interface [polypeptide binding]; other site 718254000047 putative active cleft [active] 718254000048 Class I aldolases; Region: Aldolase_Class_I; cl17187 718254000049 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 718254000050 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 718254000051 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718254000052 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 718254000053 substrate binding site [chemical binding]; other site 718254000054 ATP binding site [chemical binding]; other site 718254000055 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718254000056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254000057 DNA-binding site [nucleotide binding]; DNA binding site 718254000058 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254000059 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 718254000060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254000061 motif II; other site 718254000062 hypothetical protein; Reviewed; Region: PRK01637 718254000063 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 718254000064 putative active site [active] 718254000065 dimerization interface [polypeptide binding]; other site 718254000066 putative tRNAtyr binding site [nucleotide binding]; other site 718254000067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254000068 Coenzyme A binding pocket [chemical binding]; other site 718254000069 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 718254000070 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 718254000071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 718254000072 substrate binding pocket [chemical binding]; other site 718254000073 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 718254000074 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 718254000075 oligomeric interface; other site 718254000076 putative active site [active] 718254000077 homodimer interface [polypeptide binding]; other site 718254000078 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 718254000079 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 718254000080 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 718254000081 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 718254000082 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 718254000083 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 718254000084 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718254000085 molybdopterin cofactor binding site; other site 718254000086 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 718254000087 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 718254000088 molybdopterin cofactor binding site; other site 718254000089 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718254000090 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 718254000091 putative fimbrial chaperone protein; Provisional; Region: PRK09918 718254000092 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254000093 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254000094 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 718254000095 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254000096 PapC C-terminal domain; Region: PapC_C; pfam13953 718254000097 hypothetical protein; Provisional; Region: PRK15301 718254000098 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 718254000099 AzlC protein; Region: AzlC; cl00570 718254000100 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 718254000101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254000102 non-specific DNA binding site [nucleotide binding]; other site 718254000103 salt bridge; other site 718254000104 sequence-specific DNA binding site [nucleotide binding]; other site 718254000105 Cupin domain; Region: Cupin_2; cl17218 718254000106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254000107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254000108 DNA binding site [nucleotide binding] 718254000109 domain linker motif; other site 718254000110 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 718254000111 ligand binding site [chemical binding]; other site 718254000112 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 718254000113 Melibiase; Region: Melibiase; pfam02065 718254000114 galactoside permease; Reviewed; Region: lacY; PRK09528 718254000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000116 putative substrate translocation pore; other site 718254000117 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 718254000118 lactaldehyde reductase; Region: lactal_redase; TIGR02638 718254000119 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 718254000120 dimer interface [polypeptide binding]; other site 718254000121 active site 718254000122 metal binding site [ion binding]; metal-binding site 718254000123 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254000124 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254000125 TM-ABC transporter signature motif; other site 718254000126 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254000127 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254000128 TM-ABC transporter signature motif; other site 718254000129 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 718254000130 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254000131 Walker A/P-loop; other site 718254000132 ATP binding site [chemical binding]; other site 718254000133 Q-loop/lid; other site 718254000134 ABC transporter signature motif; other site 718254000135 Walker B; other site 718254000136 D-loop; other site 718254000137 H-loop/switch region; other site 718254000138 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254000139 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 718254000140 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 718254000141 ligand binding site [chemical binding]; other site 718254000142 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 718254000143 intersubunit interface [polypeptide binding]; other site 718254000144 active site 718254000145 Zn2+ binding site [ion binding]; other site 718254000146 L-rhamnose isomerase; Provisional; Region: PRK01076 718254000147 rhamnulokinase; Provisional; Region: rhaB; PRK10640 718254000148 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 718254000149 N- and C-terminal domain interface [polypeptide binding]; other site 718254000150 active site 718254000151 carbohydrate binding site [chemical binding]; other site 718254000152 ATP binding site [chemical binding]; other site 718254000153 transcriptional activator RhaS; Provisional; Region: PRK13503 718254000154 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 718254000155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254000156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254000157 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 718254000158 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 718254000159 superoxide dismutase; Provisional; Region: PRK10925 718254000160 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 718254000161 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 718254000162 MOSC domain; Region: MOSC; pfam03473 718254000163 two-component sensor protein; Provisional; Region: cpxA; PRK09470 718254000164 HAMP domain; Region: HAMP; pfam00672 718254000165 dimerization interface [polypeptide binding]; other site 718254000166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254000167 dimer interface [polypeptide binding]; other site 718254000168 phosphorylation site [posttranslational modification] 718254000169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254000170 ATP binding site [chemical binding]; other site 718254000171 Mg2+ binding site [ion binding]; other site 718254000172 G-X-G motif; other site 718254000173 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 718254000174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254000175 active site 718254000176 intermolecular recognition site; other site 718254000177 dimerization interface [polypeptide binding]; other site 718254000178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254000179 DNA binding site [nucleotide binding] 718254000180 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 718254000181 dimer interface [polypeptide binding]; other site 718254000182 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 718254000183 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 718254000184 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 718254000185 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 718254000186 active site 718254000187 ADP/pyrophosphate binding site [chemical binding]; other site 718254000188 dimerization interface [polypeptide binding]; other site 718254000189 allosteric effector site; other site 718254000190 fructose-1,6-bisphosphate binding site; other site 718254000191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254000192 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718254000193 substrate binding pocket [chemical binding]; other site 718254000194 membrane-bound complex binding site; other site 718254000195 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 718254000196 transmembrane helices; other site 718254000197 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718254000198 triosephosphate isomerase; Provisional; Region: PRK14567 718254000199 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 718254000200 substrate binding site [chemical binding]; other site 718254000201 dimer interface [polypeptide binding]; other site 718254000202 catalytic triad [active] 718254000203 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 718254000204 Predicted membrane protein [Function unknown]; Region: COG3152 718254000205 ferredoxin-NADP reductase; Provisional; Region: PRK10926 718254000206 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 718254000207 FAD binding pocket [chemical binding]; other site 718254000208 FAD binding motif [chemical binding]; other site 718254000209 phosphate binding motif [ion binding]; other site 718254000210 beta-alpha-beta structure motif; other site 718254000211 NAD binding pocket [chemical binding]; other site 718254000212 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 718254000213 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 718254000214 putative active site [active] 718254000215 glycerol kinase; Provisional; Region: glpK; PRK00047 718254000216 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 718254000217 N- and C-terminal domain interface [polypeptide binding]; other site 718254000218 active site 718254000219 MgATP binding site [chemical binding]; other site 718254000220 catalytic site [active] 718254000221 metal binding site [ion binding]; metal-binding site 718254000222 glycerol binding site [chemical binding]; other site 718254000223 homotetramer interface [polypeptide binding]; other site 718254000224 homodimer interface [polypeptide binding]; other site 718254000225 FBP binding site [chemical binding]; other site 718254000226 protein IIAGlc interface [polypeptide binding]; other site 718254000227 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 718254000228 amphipathic channel; other site 718254000229 Asn-Pro-Ala signature motifs; other site 718254000230 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 718254000231 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 718254000232 UbiA prenyltransferase family; Region: UbiA; pfam01040 718254000233 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 718254000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254000235 Walker A motif; other site 718254000236 ATP binding site [chemical binding]; other site 718254000237 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 718254000238 Walker B motif; other site 718254000239 arginine finger; other site 718254000240 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718254000241 cell division protein FtsN; Provisional; Region: PRK12757 718254000242 Sporulation related domain; Region: SPOR; cl10051 718254000243 Sporulation related domain; Region: SPOR; cl10051 718254000244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254000245 DNA binding site [nucleotide binding] 718254000246 domain linker motif; other site 718254000247 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 718254000248 primosome assembly protein PriA; Validated; Region: PRK05580 718254000249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718254000250 ATP binding site [chemical binding]; other site 718254000251 putative Mg++ binding site [ion binding]; other site 718254000252 helicase superfamily c-terminal domain; Region: HELICc; smart00490 718254000253 ATP-binding site [chemical binding]; other site 718254000254 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 718254000255 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 718254000256 dimerization interface [polypeptide binding]; other site 718254000257 DNA binding site [nucleotide binding] 718254000258 corepressor binding sites; other site 718254000259 cystathionine gamma-synthase; Provisional; Region: PRK08045 718254000260 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 718254000261 homodimer interface [polypeptide binding]; other site 718254000262 substrate-cofactor binding pocket; other site 718254000263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254000264 catalytic residue [active] 718254000265 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 718254000266 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 718254000267 substrate binding site [chemical binding]; other site 718254000268 nucleotide binding site [chemical binding]; other site 718254000269 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 718254000270 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 718254000271 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 718254000272 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 718254000273 FAD binding site [chemical binding]; other site 718254000274 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 718254000275 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 718254000276 heme binding site [chemical binding]; other site 718254000277 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 718254000278 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 718254000279 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 718254000280 dimer interface [polypeptide binding]; other site 718254000281 active site 718254000282 metal binding site [ion binding]; metal-binding site 718254000283 Class I aldolases; Region: Aldolase_Class_I; cl17187 718254000284 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 718254000285 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 718254000286 acetylornithine deacetylase; Provisional; Region: PRK05111 718254000287 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 718254000288 metal binding site [ion binding]; metal-binding site 718254000289 putative dimer interface [polypeptide binding]; other site 718254000290 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 718254000291 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718254000292 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 718254000293 nucleotide binding site [chemical binding]; other site 718254000294 N-acetyl-L-glutamate binding site [chemical binding]; other site 718254000295 argininosuccinate lyase; Provisional; Region: PRK04833 718254000296 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 718254000297 active sites [active] 718254000298 tetramer interface [polypeptide binding]; other site 718254000299 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 718254000300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254000301 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 718254000302 dimerization interface [polypeptide binding]; other site 718254000303 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 718254000304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254000305 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718254000306 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 718254000307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254000308 hypothetical protein; Provisional; Region: PRK11056 718254000309 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 718254000310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254000311 S-adenosylmethionine binding site [chemical binding]; other site 718254000312 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 718254000313 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 718254000314 purine monophosphate binding site [chemical binding]; other site 718254000315 dimer interface [polypeptide binding]; other site 718254000316 putative catalytic residues [active] 718254000317 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 718254000318 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 718254000319 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 718254000320 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 718254000321 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 718254000322 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 718254000323 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718254000324 IHF dimer interface [polypeptide binding]; other site 718254000325 IHF - DNA interface [nucleotide binding]; other site 718254000326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 718254000327 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 718254000328 Active_site [active] 718254000329 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 718254000330 substrate binding site [chemical binding]; other site 718254000331 active site 718254000332 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 718254000333 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 718254000334 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 718254000335 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 718254000336 putative NADH binding site [chemical binding]; other site 718254000337 putative active site [active] 718254000338 nudix motif; other site 718254000339 putative metal binding site [ion binding]; other site 718254000340 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 718254000341 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 718254000342 ThiC-associated domain; Region: ThiC-associated; pfam13667 718254000343 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 718254000344 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 718254000345 thiamine phosphate binding site [chemical binding]; other site 718254000346 active site 718254000347 pyrophosphate binding site [ion binding]; other site 718254000348 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 718254000349 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 718254000350 ATP binding site [chemical binding]; other site 718254000351 substrate interface [chemical binding]; other site 718254000352 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 718254000353 thiS-thiF/thiG interaction site; other site 718254000354 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 718254000355 ThiS interaction site; other site 718254000356 putative active site [active] 718254000357 tetramer interface [polypeptide binding]; other site 718254000358 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 718254000359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254000360 FeS/SAM binding site; other site 718254000361 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 718254000362 Cache domain; Region: Cache_1; pfam02743 718254000363 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254000364 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254000365 metal binding site [ion binding]; metal-binding site 718254000366 active site 718254000367 I-site; other site 718254000368 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 718254000369 active site 718254000370 methionine cluster; other site 718254000371 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 718254000372 active site 718254000373 phosphorylation site [posttranslational modification] 718254000374 metal binding site [ion binding]; metal-binding site 718254000375 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 718254000376 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 718254000377 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 718254000378 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718254000379 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 718254000380 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718254000381 RPB3 interaction site [polypeptide binding]; other site 718254000382 RPB1 interaction site [polypeptide binding]; other site 718254000383 RPB11 interaction site [polypeptide binding]; other site 718254000384 RPB10 interaction site [polypeptide binding]; other site 718254000385 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 718254000386 core dimer interface [polypeptide binding]; other site 718254000387 peripheral dimer interface [polypeptide binding]; other site 718254000388 L10 interface [polypeptide binding]; other site 718254000389 L11 interface [polypeptide binding]; other site 718254000390 putative EF-Tu interaction site [polypeptide binding]; other site 718254000391 putative EF-G interaction site [polypeptide binding]; other site 718254000392 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 718254000393 23S rRNA interface [nucleotide binding]; other site 718254000394 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 718254000395 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 718254000396 mRNA/rRNA interface [nucleotide binding]; other site 718254000397 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 718254000398 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 718254000399 23S rRNA interface [nucleotide binding]; other site 718254000400 L7/L12 interface [polypeptide binding]; other site 718254000401 putative thiostrepton binding site; other site 718254000402 L25 interface [polypeptide binding]; other site 718254000403 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 718254000404 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 718254000405 putative homodimer interface [polypeptide binding]; other site 718254000406 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 718254000407 heterodimer interface [polypeptide binding]; other site 718254000408 homodimer interface [polypeptide binding]; other site 718254000409 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 718254000410 pantothenate kinase; Provisional; Region: PRK05439 718254000411 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 718254000412 ATP-binding site [chemical binding]; other site 718254000413 CoA-binding site [chemical binding]; other site 718254000414 Mg2+-binding site [ion binding]; other site 718254000415 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 718254000416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254000417 Walker A/P-loop; other site 718254000418 ATP binding site [chemical binding]; other site 718254000419 Q-loop/lid; other site 718254000420 ABC transporter signature motif; other site 718254000421 Walker B; other site 718254000422 D-loop; other site 718254000423 H-loop/switch region; other site 718254000424 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 718254000425 dipeptide transporter; Provisional; Region: PRK10913 718254000426 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 718254000427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254000428 dimer interface [polypeptide binding]; other site 718254000429 conserved gate region; other site 718254000430 putative PBP binding loops; other site 718254000431 ABC-ATPase subunit interface; other site 718254000432 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718254000433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254000434 dimer interface [polypeptide binding]; other site 718254000435 conserved gate region; other site 718254000436 putative PBP binding loops; other site 718254000437 ABC-ATPase subunit interface; other site 718254000438 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718254000439 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 718254000440 peptide binding site [polypeptide binding]; other site 718254000441 phosphoethanolamine transferase; Provisional; Region: PRK11560 718254000442 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 718254000443 Sulfatase; Region: Sulfatase; pfam00884 718254000444 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 718254000445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000446 putative substrate translocation pore; other site 718254000447 Autotransporter beta-domain; Region: Autotransporter; cl17461 718254000448 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 718254000449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 718254000450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254000451 Coenzyme A binding pocket [chemical binding]; other site 718254000452 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 718254000453 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 718254000454 molybdopterin cofactor binding site [chemical binding]; other site 718254000455 substrate binding site [chemical binding]; other site 718254000456 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 718254000457 molybdopterin cofactor binding site; other site 718254000458 putative outer membrane lipoprotein; Provisional; Region: PRK10510 718254000459 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718254000460 ligand binding site [chemical binding]; other site 718254000461 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254000462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254000463 DNA binding site [nucleotide binding] 718254000464 domain linker motif; other site 718254000465 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 718254000466 putative dimerization interface [polypeptide binding]; other site 718254000467 putative ligand binding site [chemical binding]; other site 718254000468 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 718254000469 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718254000470 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 718254000471 substrate binding site [chemical binding]; other site 718254000472 ATP binding site [chemical binding]; other site 718254000473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000474 D-galactonate transporter; Region: 2A0114; TIGR00893 718254000475 putative substrate translocation pore; other site 718254000476 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 718254000477 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 718254000478 dimerization interface [polypeptide binding]; other site 718254000479 ligand binding site [chemical binding]; other site 718254000480 NADP binding site [chemical binding]; other site 718254000481 catalytic site [active] 718254000482 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718254000483 DNA-binding site [nucleotide binding]; DNA binding site 718254000484 RNA-binding motif; other site 718254000485 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 718254000486 Predicted transcriptional regulator [Transcription]; Region: COG2944 718254000487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254000488 salt bridge; other site 718254000489 non-specific DNA binding site [nucleotide binding]; other site 718254000490 sequence-specific DNA binding site [nucleotide binding]; other site 718254000491 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 718254000492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254000493 Walker A/P-loop; other site 718254000494 ATP binding site [chemical binding]; other site 718254000495 Q-loop/lid; other site 718254000496 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254000497 ABC transporter signature motif; other site 718254000498 Walker B; other site 718254000499 D-loop; other site 718254000500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254000501 FMN reductase; Validated; Region: fre; PRK08051 718254000502 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 718254000503 FAD binding pocket [chemical binding]; other site 718254000504 FAD binding motif [chemical binding]; other site 718254000505 phosphate binding motif [ion binding]; other site 718254000506 beta-alpha-beta structure motif; other site 718254000507 NAD binding pocket [chemical binding]; other site 718254000508 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 718254000509 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 718254000510 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 718254000511 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 718254000512 active site 718254000513 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 718254000514 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 718254000515 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 718254000516 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 718254000517 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 718254000518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254000519 S-adenosylmethionine binding site [chemical binding]; other site 718254000520 uridine phosphorylase; Provisional; Region: PRK11178 718254000521 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 718254000522 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 718254000523 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 718254000524 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 718254000525 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 718254000526 THF binding site; other site 718254000527 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 718254000528 substrate binding site [chemical binding]; other site 718254000529 THF binding site; other site 718254000530 zinc-binding site [ion binding]; other site 718254000531 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 718254000532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254000533 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 718254000534 putative dimerization interface [polypeptide binding]; other site 718254000535 putative hydrolase; Provisional; Region: PRK10976 718254000536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254000537 active site 718254000538 motif I; other site 718254000539 motif II; other site 718254000540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254000541 lysophospholipase L2; Provisional; Region: PRK10749 718254000542 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718254000543 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 718254000544 threonine efflux system; Provisional; Region: PRK10229 718254000545 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 718254000546 dimerization interface [polypeptide binding]; other site 718254000547 substrate binding site [chemical binding]; other site 718254000548 active site 718254000549 calcium binding site [ion binding]; other site 718254000550 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 718254000551 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 718254000552 CoenzymeA binding site [chemical binding]; other site 718254000553 subunit interaction site [polypeptide binding]; other site 718254000554 PHB binding site; other site 718254000555 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 718254000556 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 718254000557 Cl binding site [ion binding]; other site 718254000558 oligomer interface [polypeptide binding]; other site 718254000559 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 718254000560 Part of AAA domain; Region: AAA_19; pfam13245 718254000561 Family description; Region: UvrD_C_2; pfam13538 718254000562 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 718254000563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254000564 motif II; other site 718254000565 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 718254000566 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718254000567 active site 718254000568 DNA binding site [nucleotide binding] 718254000569 Int/Topo IB signature motif; other site 718254000570 hypothetical protein; Provisional; Region: PRK10963 718254000571 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 718254000572 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718254000573 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718254000574 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 718254000575 putative iron binding site [ion binding]; other site 718254000576 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 718254000577 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 718254000578 active site 718254000579 domain interfaces; other site 718254000580 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 718254000581 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 718254000582 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 718254000583 HemY protein N-terminus; Region: HemY_N; pfam07219 718254000584 putative transport protein YifK; Provisional; Region: PRK10746 718254000585 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 718254000586 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 718254000587 putative common antigen polymerase; Provisional; Region: PRK02975 718254000588 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 718254000589 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 718254000590 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 718254000591 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 718254000592 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718254000593 inhibitor-cofactor binding pocket; inhibition site 718254000594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254000595 catalytic residue [active] 718254000596 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 718254000597 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 718254000598 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 718254000599 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 718254000600 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 718254000601 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 718254000602 homodimer interface [polypeptide binding]; other site 718254000603 active site 718254000604 transcription termination factor Rho; Provisional; Region: rho; PRK09376 718254000605 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 718254000606 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 718254000607 RNA binding site [nucleotide binding]; other site 718254000608 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 718254000609 multimer interface [polypeptide binding]; other site 718254000610 Walker A motif; other site 718254000611 ATP binding site [chemical binding]; other site 718254000612 Walker B motif; other site 718254000613 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 718254000614 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718254000615 catalytic residues [active] 718254000616 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 718254000617 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718254000618 ATP binding site [chemical binding]; other site 718254000619 Mg++ binding site [ion binding]; other site 718254000620 motif III; other site 718254000621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254000622 nucleotide binding region [chemical binding]; other site 718254000623 ATP-binding site [chemical binding]; other site 718254000624 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 718254000625 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 718254000626 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 718254000627 Part of AAA domain; Region: AAA_19; pfam13245 718254000628 Family description; Region: UvrD_C_2; pfam13538 718254000629 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 718254000630 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 718254000631 serine acetyltransferase; Provisional; Region: cysE; PRK11132 718254000632 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 718254000633 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 718254000634 trimer interface [polypeptide binding]; other site 718254000635 active site 718254000636 substrate binding site [chemical binding]; other site 718254000637 CoA binding site [chemical binding]; other site 718254000638 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 718254000639 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 718254000640 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 718254000641 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 718254000642 SecA binding site; other site 718254000643 Preprotein binding site; other site 718254000644 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 718254000645 GSH binding site [chemical binding]; other site 718254000646 catalytic residues [active] 718254000647 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718254000648 active site residue [active] 718254000649 phosphoglyceromutase; Provisional; Region: PRK05434 718254000650 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 718254000651 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718254000652 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 718254000653 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718254000654 NAD(P) binding site [chemical binding]; other site 718254000655 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 718254000656 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 718254000657 substrate-cofactor binding pocket; other site 718254000658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254000659 catalytic residue [active] 718254000660 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 718254000661 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 718254000662 NADP binding site [chemical binding]; other site 718254000663 homopentamer interface [polypeptide binding]; other site 718254000664 substrate binding site [chemical binding]; other site 718254000665 active site 718254000666 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 718254000667 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718254000668 putative active site [active] 718254000669 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718254000670 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 718254000671 putative active site [active] 718254000672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718254000673 active site 718254000674 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 718254000675 O-Antigen ligase; Region: Wzy_C; pfam04932 718254000676 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 718254000677 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718254000678 putative active site [active] 718254000679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718254000680 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 718254000681 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 718254000682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718254000683 putative ADP-binding pocket [chemical binding]; other site 718254000684 putative glycosyl transferase; Provisional; Region: PRK10073 718254000685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718254000686 active site 718254000687 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718254000688 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 718254000689 putative metal binding site; other site 718254000690 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 718254000691 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 718254000692 active site 718254000693 (T/H)XGH motif; other site 718254000694 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 718254000695 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 718254000696 DNA binding site [nucleotide binding] 718254000697 catalytic residue [active] 718254000698 H2TH interface [polypeptide binding]; other site 718254000699 putative catalytic residues [active] 718254000700 turnover-facilitating residue; other site 718254000701 intercalation triad [nucleotide binding]; other site 718254000702 8OG recognition residue [nucleotide binding]; other site 718254000703 putative reading head residues; other site 718254000704 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 718254000705 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 718254000706 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 718254000707 hypothetical protein; Reviewed; Region: PRK00024 718254000708 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 718254000709 MPN+ (JAMM) motif; other site 718254000710 Zinc-binding site [ion binding]; other site 718254000711 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 718254000712 Flavoprotein; Region: Flavoprotein; pfam02441 718254000713 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 718254000714 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 718254000715 trimer interface [polypeptide binding]; other site 718254000716 active site 718254000717 division inhibitor protein; Provisional; Region: slmA; PRK09480 718254000718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254000719 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718254000720 active site 718254000721 ribonuclease PH; Reviewed; Region: rph; PRK00173 718254000722 Ribonuclease PH; Region: RNase_PH_bact; cd11362 718254000723 hexamer interface [polypeptide binding]; other site 718254000724 active site 718254000725 hypothetical protein; Provisional; Region: PRK11820 718254000726 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 718254000727 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 718254000728 Predicted membrane protein [Function unknown]; Region: COG2860 718254000729 UPF0126 domain; Region: UPF0126; pfam03458 718254000730 UPF0126 domain; Region: UPF0126; pfam03458 718254000731 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 718254000732 Chain length determinant protein; Region: Wzz; pfam02706 718254000733 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 718254000734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718254000735 Low molecular weight phosphatase family; Region: LMWPc; cd00115 718254000736 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 718254000737 active site 718254000738 polysaccharide export protein Wza; Provisional; Region: PRK15078 718254000739 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 718254000740 SLBB domain; Region: SLBB; pfam10531 718254000741 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 718254000742 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 718254000743 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 718254000744 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 718254000745 nucleotide binding pocket [chemical binding]; other site 718254000746 K-X-D-G motif; other site 718254000747 catalytic site [active] 718254000748 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 718254000749 Phage integrase protein; Region: DUF3701; pfam12482 718254000750 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 718254000751 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 718254000752 catalytic site [active] 718254000753 G-X2-G-X-G-K; other site 718254000754 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 718254000755 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 718254000756 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 718254000757 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 718254000758 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 718254000759 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 718254000760 generic binding surface II; other site 718254000761 ssDNA binding site; other site 718254000762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718254000763 ATP binding site [chemical binding]; other site 718254000764 putative Mg++ binding site [ion binding]; other site 718254000765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254000766 nucleotide binding region [chemical binding]; other site 718254000767 ATP-binding site [chemical binding]; other site 718254000768 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 718254000769 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 718254000770 putative alpha-glucosidase; Provisional; Region: PRK10658 718254000771 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 718254000772 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 718254000773 active site 718254000774 homotrimer interface [polypeptide binding]; other site 718254000775 catalytic site [active] 718254000776 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 718254000777 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 718254000778 putative transporter; Provisional; Region: PRK11462 718254000779 integrase; Provisional; Region: PRK09692 718254000780 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718254000781 active site 718254000782 Int/Topo IB signature motif; other site 718254000783 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 718254000784 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 718254000785 Ash protein family; Region: Phage_ASH; pfam10554 718254000786 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718254000787 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 718254000788 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 718254000789 Virulence protein [General function prediction only]; Region: COG3943 718254000790 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 718254000791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 718254000792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254000793 Coenzyme A binding pocket [chemical binding]; other site 718254000794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718254000795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254000796 DNA binding residues [nucleotide binding] 718254000797 dimerization interface [polypeptide binding]; other site 718254000798 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254000799 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254000800 PapC N-terminal domain; Region: PapC_N; pfam13954 718254000801 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254000802 PapC C-terminal domain; Region: PapC_C; pfam13953 718254000803 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254000804 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254000805 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 718254000806 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 718254000807 transcriptional regulator MirA; Provisional; Region: PRK15043 718254000808 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 718254000809 DNA binding residues [nucleotide binding] 718254000810 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 718254000811 active site 718254000812 homotetramer interface [polypeptide binding]; other site 718254000813 Protein of unknown function (DUF523); Region: DUF523; pfam04463 718254000814 Uncharacterized conserved protein [Function unknown]; Region: COG3272 718254000815 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 718254000816 Predicted ATPase [General function prediction only]; Region: COG4637 718254000817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254000818 Walker A/P-loop; other site 718254000819 ATP binding site [chemical binding]; other site 718254000820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254000821 ABC transporter signature motif; other site 718254000822 Walker B; other site 718254000823 D-loop; other site 718254000824 H-loop/switch region; other site 718254000825 Protein of unknown function (DUF796); Region: DUF796; cl01226 718254000826 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 718254000827 antitoxin YefM; Provisional; Region: PRK11409 718254000828 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 718254000829 Peptidase C39 family; Region: Peptidase_C39; pfam03412 718254000830 putative active site [active] 718254000831 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718254000832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254000833 Walker A/P-loop; other site 718254000834 ATP binding site [chemical binding]; other site 718254000835 Q-loop/lid; other site 718254000836 ABC transporter signature motif; other site 718254000837 Walker B; other site 718254000838 D-loop; other site 718254000839 H-loop/switch region; other site 718254000840 putative fimbrial protein TcfA; Provisional; Region: PRK15308 718254000841 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254000842 putative fimbrial protein TcfA; Provisional; Region: PRK15308 718254000843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718254000844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254000845 DNA binding site [nucleotide binding] 718254000846 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254000847 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718254000848 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254000849 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254000850 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254000851 PapC N-terminal domain; Region: PapC_N; pfam13954 718254000852 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254000853 PapC C-terminal domain; Region: PapC_C; pfam13953 718254000854 transcriptional regulator RcsB; Provisional; Region: PRK10840 718254000855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254000856 DNA binding residues [nucleotide binding] 718254000857 dimerization interface [polypeptide binding]; other site 718254000858 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718254000859 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 718254000860 DNA binding residues [nucleotide binding] 718254000861 EAL domain; Region: EAL; pfam00563 718254000862 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 718254000863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000864 putative substrate translocation pore; other site 718254000865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718254000866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254000867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254000868 Coenzyme A binding pocket [chemical binding]; other site 718254000869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718254000870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254000871 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 718254000872 Protein export membrane protein; Region: SecD_SecF; cl14618 718254000873 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 718254000874 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 718254000875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000876 putative substrate translocation pore; other site 718254000877 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254000878 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254000879 DNA binding site [nucleotide binding] 718254000880 domain linker motif; other site 718254000881 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 718254000882 ligand binding site [chemical binding]; other site 718254000883 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 718254000884 active site 718254000885 P-loop; other site 718254000886 phosphorylation site [posttranslational modification] 718254000887 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 718254000888 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 718254000889 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 718254000890 beta-galactosidase; Region: BGL; TIGR03356 718254000891 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 718254000892 methionine cluster; other site 718254000893 active site 718254000894 phosphorylation site [posttranslational modification] 718254000895 metal binding site [ion binding]; metal-binding site 718254000896 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 718254000897 EamA-like transporter family; Region: EamA; pfam00892 718254000898 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 718254000899 EamA-like transporter family; Region: EamA; pfam00892 718254000900 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 718254000901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000902 putative substrate translocation pore; other site 718254000903 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 718254000904 putative hydrophobic ligand binding site [chemical binding]; other site 718254000905 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 718254000906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254000907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254000908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254000909 dimerization interface [polypeptide binding]; other site 718254000910 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 718254000911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000912 putative substrate translocation pore; other site 718254000913 regulatory protein UhpC; Provisional; Region: PRK11663 718254000914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000915 putative substrate translocation pore; other site 718254000916 sensory histidine kinase UhpB; Provisional; Region: PRK11644 718254000917 MASE1; Region: MASE1; pfam05231 718254000918 Histidine kinase; Region: HisKA_3; pfam07730 718254000919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254000920 ATP binding site [chemical binding]; other site 718254000921 Mg2+ binding site [ion binding]; other site 718254000922 G-X-G motif; other site 718254000923 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 718254000924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254000925 active site 718254000926 phosphorylation site [posttranslational modification] 718254000927 intermolecular recognition site; other site 718254000928 dimerization interface [polypeptide binding]; other site 718254000929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254000930 DNA binding residues [nucleotide binding] 718254000931 dimerization interface [polypeptide binding]; other site 718254000932 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 718254000933 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 718254000934 putative valine binding site [chemical binding]; other site 718254000935 dimer interface [polypeptide binding]; other site 718254000936 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 718254000937 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 718254000938 PYR/PP interface [polypeptide binding]; other site 718254000939 dimer interface [polypeptide binding]; other site 718254000940 TPP binding site [chemical binding]; other site 718254000941 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718254000942 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 718254000943 TPP-binding site [chemical binding]; other site 718254000944 dimer interface [polypeptide binding]; other site 718254000945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254000946 non-specific DNA binding site [nucleotide binding]; other site 718254000947 salt bridge; other site 718254000948 sequence-specific DNA binding site [nucleotide binding]; other site 718254000949 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 718254000950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 718254000951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254000952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 718254000953 Coenzyme A binding pocket [chemical binding]; other site 718254000954 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 718254000955 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 718254000956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000957 putative substrate translocation pore; other site 718254000958 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 718254000959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254000960 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 718254000961 dimerization interface [polypeptide binding]; other site 718254000962 substrate binding pocket [chemical binding]; other site 718254000963 permease DsdX; Provisional; Region: PRK09921 718254000964 gluconate transporter; Region: gntP; TIGR00791 718254000965 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 718254000966 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 718254000967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718254000968 catalytic residue [active] 718254000969 Domain of unknown function (DUF202); Region: DUF202; pfam02656 718254000970 Predicted membrane protein [Function unknown]; Region: COG2149 718254000971 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 718254000972 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 718254000973 NAD binding site [chemical binding]; other site 718254000974 sugar binding site [chemical binding]; other site 718254000975 divalent metal binding site [ion binding]; other site 718254000976 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 718254000977 dimer interface [polypeptide binding]; other site 718254000978 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 718254000979 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 718254000980 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254000981 active site turn [active] 718254000982 phosphorylation site [posttranslational modification] 718254000983 putative transporter; Validated; Region: PRK03818 718254000984 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 718254000985 TrkA-C domain; Region: TrkA_C; pfam02080 718254000986 TrkA-C domain; Region: TrkA_C; pfam02080 718254000987 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 718254000988 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 718254000989 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 718254000990 putative dimer interface [polypeptide binding]; other site 718254000991 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 718254000992 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 718254000993 putative dimer interface [polypeptide binding]; other site 718254000994 hypothetical protein; Provisional; Region: PRK11616 718254000995 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 718254000996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254000997 D-galactonate transporter; Region: 2A0114; TIGR00893 718254000998 putative substrate translocation pore; other site 718254000999 galactonate dehydratase; Provisional; Region: PRK14017 718254001000 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 718254001001 putative active site pocket [active] 718254001002 putative metal binding site [ion binding]; other site 718254001003 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 718254001004 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 718254001005 Transcriptional regulators [Transcription]; Region: FadR; COG2186 718254001006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254001007 DNA-binding site [nucleotide binding]; DNA binding site 718254001008 FCD domain; Region: FCD; pfam07729 718254001009 sugar phosphate phosphatase; Provisional; Region: PRK10513 718254001010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254001011 active site 718254001012 motif I; other site 718254001013 motif II; other site 718254001014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254001015 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 718254001016 Enoylreductase; Region: PKS_ER; smart00829 718254001017 putative NAD(P) binding site [chemical binding]; other site 718254001018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254001019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254001020 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 718254001021 putative effector binding pocket; other site 718254001022 putative dimerization interface [polypeptide binding]; other site 718254001023 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 718254001024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254001025 Mg2+ binding site [ion binding]; other site 718254001026 G-X-G motif; other site 718254001027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 718254001028 anchoring element; other site 718254001029 dimer interface [polypeptide binding]; other site 718254001030 ATP binding site [chemical binding]; other site 718254001031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 718254001032 active site 718254001033 putative metal-binding site [ion binding]; other site 718254001034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 718254001035 recF protein; Region: recf; TIGR00611 718254001036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254001037 Walker A/P-loop; other site 718254001038 ATP binding site [chemical binding]; other site 718254001039 Q-loop/lid; other site 718254001040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254001041 ABC transporter signature motif; other site 718254001042 Walker B; other site 718254001043 D-loop; other site 718254001044 H-loop/switch region; other site 718254001045 DNA polymerase III subunit beta; Validated; Region: PRK05643 718254001046 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 718254001047 putative DNA binding surface [nucleotide binding]; other site 718254001048 dimer interface [polypeptide binding]; other site 718254001049 beta-clamp/clamp loader binding surface; other site 718254001050 beta-clamp/translesion DNA polymerase binding surface; other site 718254001051 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 718254001052 DnaA N-terminal domain; Region: DnaA_N; pfam11638 718254001053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254001054 Walker A motif; other site 718254001055 ATP binding site [chemical binding]; other site 718254001056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 718254001057 Walker B motif; other site 718254001058 arginine finger; other site 718254001059 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 718254001060 DnaA box-binding interface [nucleotide binding]; other site 718254001061 membrane protein insertase; Provisional; Region: PRK01318 718254001062 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 718254001063 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 718254001064 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 718254001065 trmE is a tRNA modification GTPase; Region: trmE; cd04164 718254001066 G1 box; other site 718254001067 GTP/Mg2+ binding site [chemical binding]; other site 718254001068 Switch I region; other site 718254001069 G2 box; other site 718254001070 Switch II region; other site 718254001071 G3 box; other site 718254001072 G4 box; other site 718254001073 G5 box; other site 718254001074 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 718254001075 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 718254001076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001077 putative substrate translocation pore; other site 718254001078 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 718254001079 Predicted flavoprotein [General function prediction only]; Region: COG0431 718254001080 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 718254001081 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 718254001082 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 718254001083 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 718254001084 Walker A/P-loop; other site 718254001085 ATP binding site [chemical binding]; other site 718254001086 Q-loop/lid; other site 718254001087 ABC transporter signature motif; other site 718254001088 Walker B; other site 718254001089 D-loop; other site 718254001090 H-loop/switch region; other site 718254001091 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 718254001092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254001093 dimer interface [polypeptide binding]; other site 718254001094 conserved gate region; other site 718254001095 putative PBP binding loops; other site 718254001096 ABC-ATPase subunit interface; other site 718254001097 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 718254001098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254001099 dimer interface [polypeptide binding]; other site 718254001100 conserved gate region; other site 718254001101 putative PBP binding loops; other site 718254001102 ABC-ATPase subunit interface; other site 718254001103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254001104 Fimbrial protein; Region: Fimbrial; cl01416 718254001105 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254001106 PapC N-terminal domain; Region: PapC_N; pfam13954 718254001107 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254001108 PapC C-terminal domain; Region: PapC_C; pfam13953 718254001109 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 718254001110 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254001111 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254001112 Fimbrial protein; Region: Fimbrial; cl01416 718254001113 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 718254001114 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 718254001115 glutaminase active site [active] 718254001116 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 718254001117 dimer interface [polypeptide binding]; other site 718254001118 active site 718254001119 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 718254001120 dimer interface [polypeptide binding]; other site 718254001121 active site 718254001122 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 718254001123 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 718254001124 Substrate binding site; other site 718254001125 Mg++ binding site; other site 718254001126 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 718254001127 active site 718254001128 substrate binding site [chemical binding]; other site 718254001129 CoA binding site [chemical binding]; other site 718254001130 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 718254001131 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 718254001132 gamma subunit interface [polypeptide binding]; other site 718254001133 epsilon subunit interface [polypeptide binding]; other site 718254001134 LBP interface [polypeptide binding]; other site 718254001135 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 718254001136 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718254001137 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 718254001138 alpha subunit interaction interface [polypeptide binding]; other site 718254001139 Walker A motif; other site 718254001140 ATP binding site [chemical binding]; other site 718254001141 Walker B motif; other site 718254001142 inhibitor binding site; inhibition site 718254001143 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 718254001144 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 718254001145 core domain interface [polypeptide binding]; other site 718254001146 delta subunit interface [polypeptide binding]; other site 718254001147 epsilon subunit interface [polypeptide binding]; other site 718254001148 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 718254001149 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718254001150 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 718254001151 beta subunit interaction interface [polypeptide binding]; other site 718254001152 Walker A motif; other site 718254001153 ATP binding site [chemical binding]; other site 718254001154 Walker B motif; other site 718254001155 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 718254001156 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 718254001157 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 718254001158 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 718254001159 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 718254001160 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 718254001161 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 718254001162 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 718254001163 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 718254001164 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 718254001165 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 718254001166 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 718254001167 FMN-binding protein MioC; Provisional; Region: PRK09004 718254001168 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 718254001169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254001170 putative DNA binding site [nucleotide binding]; other site 718254001171 putative Zn2+ binding site [ion binding]; other site 718254001172 AsnC family; Region: AsnC_trans_reg; pfam01037 718254001173 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 718254001174 dimer interface [polypeptide binding]; other site 718254001175 active site 718254001176 hypothetical protein; Provisional; Region: yieM; PRK10997 718254001177 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 718254001178 metal ion-dependent adhesion site (MIDAS); other site 718254001179 regulatory ATPase RavA; Provisional; Region: PRK13531 718254001180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254001181 Walker A motif; other site 718254001182 ATP binding site [chemical binding]; other site 718254001183 Walker B motif; other site 718254001184 arginine finger; other site 718254001185 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 718254001186 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 718254001187 potassium uptake protein; Region: kup; TIGR00794 718254001188 D-ribose pyranase; Provisional; Region: PRK11797 718254001189 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 718254001190 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254001191 Walker A/P-loop; other site 718254001192 ATP binding site [chemical binding]; other site 718254001193 Q-loop/lid; other site 718254001194 ABC transporter signature motif; other site 718254001195 Walker B; other site 718254001196 D-loop; other site 718254001197 H-loop/switch region; other site 718254001198 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254001199 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254001200 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254001201 TM-ABC transporter signature motif; other site 718254001202 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 718254001203 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 718254001204 ligand binding site [chemical binding]; other site 718254001205 dimerization interface [polypeptide binding]; other site 718254001206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718254001207 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 718254001208 substrate binding site [chemical binding]; other site 718254001209 dimer interface [polypeptide binding]; other site 718254001210 ATP binding site [chemical binding]; other site 718254001211 transcriptional repressor RbsR; Provisional; Region: PRK10423 718254001212 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254001213 DNA binding site [nucleotide binding] 718254001214 domain linker motif; other site 718254001215 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 718254001216 dimerization interface [polypeptide binding]; other site 718254001217 ligand binding site [chemical binding]; other site 718254001218 putative transporter; Provisional; Region: PRK10504 718254001219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001220 putative substrate translocation pore; other site 718254001221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001222 Transcriptional regulators [Transcription]; Region: FadR; COG2186 718254001223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254001224 DNA-binding site [nucleotide binding]; DNA binding site 718254001225 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718254001226 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 718254001227 malate synthase A; Region: malate_syn_A; TIGR01344 718254001228 active site 718254001229 isocitrate lyase; Provisional; Region: PRK15063 718254001230 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 718254001231 tetramer interface [polypeptide binding]; other site 718254001232 active site 718254001233 Mg2+/Mn2+ binding site [ion binding]; other site 718254001234 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 718254001235 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 718254001236 transcriptional repressor IclR; Provisional; Region: PRK11569 718254001237 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 718254001238 Bacterial transcriptional regulator; Region: IclR; pfam01614 718254001239 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 718254001240 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 718254001241 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 718254001242 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 718254001243 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 718254001244 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718254001245 RNA binding surface [nucleotide binding]; other site 718254001246 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 718254001247 probable active site [active] 718254001248 hypothetical protein; Provisional; Region: PRK10515 718254001249 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 718254001250 Sodium Bile acid symporter family; Region: SBF; pfam01758 718254001251 aspartate kinase III; Validated; Region: PRK09084 718254001252 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 718254001253 nucleotide binding site [chemical binding]; other site 718254001254 putative catalytic residues [active] 718254001255 aspartate binding site [chemical binding]; other site 718254001256 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 718254001257 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 718254001258 dimer interface [polypeptide binding]; other site 718254001259 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 718254001260 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 718254001261 active site 718254001262 dimer interface [polypeptide binding]; other site 718254001263 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 718254001264 dimer interface [polypeptide binding]; other site 718254001265 active site 718254001266 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 718254001267 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 718254001268 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 718254001269 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 718254001270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254001271 dimer interface [polypeptide binding]; other site 718254001272 conserved gate region; other site 718254001273 putative PBP binding loops; other site 718254001274 ABC-ATPase subunit interface; other site 718254001275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254001276 dimer interface [polypeptide binding]; other site 718254001277 conserved gate region; other site 718254001278 putative PBP binding loops; other site 718254001279 ABC-ATPase subunit interface; other site 718254001280 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 718254001281 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 718254001282 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 718254001283 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 718254001284 Walker A/P-loop; other site 718254001285 ATP binding site [chemical binding]; other site 718254001286 Q-loop/lid; other site 718254001287 ABC transporter signature motif; other site 718254001288 Walker B; other site 718254001289 D-loop; other site 718254001290 H-loop/switch region; other site 718254001291 TOBE domain; Region: TOBE_2; pfam08402 718254001292 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 718254001293 trimer interface; other site 718254001294 sugar binding site [chemical binding]; other site 718254001295 maltose regulon periplasmic protein; Provisional; Region: PRK10564 718254001296 PGAP1-like protein; Region: PGAP1; pfam07819 718254001297 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 718254001298 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 718254001299 UbiA prenyltransferase family; Region: UbiA; pfam01040 718254001300 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 718254001301 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 718254001302 putative acyl-acceptor binding pocket; other site 718254001303 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 718254001304 LexA repressor; Validated; Region: PRK00215 718254001305 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 718254001306 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718254001307 Catalytic site [active] 718254001308 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 718254001309 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 718254001310 hypothetical protein; Provisional; Region: PRK10428 718254001311 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 718254001312 metal binding site 2 [ion binding]; metal-binding site 718254001313 putative DNA binding helix; other site 718254001314 metal binding site 1 [ion binding]; metal-binding site 718254001315 dimer interface [polypeptide binding]; other site 718254001316 structural Zn2+ binding site [ion binding]; other site 718254001317 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 718254001318 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718254001319 FMN binding site [chemical binding]; other site 718254001320 active site 718254001321 catalytic residues [active] 718254001322 substrate binding site [chemical binding]; other site 718254001323 phage shock protein G; Reviewed; Region: pspG; PRK09459 718254001324 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 718254001325 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 718254001326 NADP binding site [chemical binding]; other site 718254001327 dimer interface [polypeptide binding]; other site 718254001328 replicative DNA helicase; Provisional; Region: PRK08006 718254001329 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 718254001330 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 718254001331 Walker A motif; other site 718254001332 ATP binding site [chemical binding]; other site 718254001333 Walker B motif; other site 718254001334 DNA binding loops [nucleotide binding] 718254001335 alanine racemase; Reviewed; Region: alr; PRK00053 718254001336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 718254001337 active site 718254001338 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718254001339 substrate binding site [chemical binding]; other site 718254001340 catalytic residues [active] 718254001341 dimer interface [polypeptide binding]; other site 718254001342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254001343 active site 718254001344 motif I; other site 718254001345 motif II; other site 718254001346 Uncharacterized conserved protein [Function unknown]; Region: COG0432 718254001347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 718254001348 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 718254001349 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718254001350 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718254001351 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 718254001352 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 718254001353 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 718254001354 dimer interface [polypeptide binding]; other site 718254001355 ssDNA binding site [nucleotide binding]; other site 718254001356 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718254001357 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 718254001358 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 718254001359 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 718254001360 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254001361 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 718254001362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254001363 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 718254001364 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 718254001365 putative C-terminal domain interface [polypeptide binding]; other site 718254001366 putative GSH binding site (G-site) [chemical binding]; other site 718254001367 putative dimer interface [polypeptide binding]; other site 718254001368 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 718254001369 putative N-terminal domain interface [polypeptide binding]; other site 718254001370 putative dimer interface [polypeptide binding]; other site 718254001371 putative substrate binding pocket (H-site) [chemical binding]; other site 718254001372 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 718254001373 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 718254001374 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 718254001375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254001376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254001377 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 718254001378 putative dimerization interface [polypeptide binding]; other site 718254001379 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 718254001380 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 718254001381 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 718254001382 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 718254001383 Na binding site [ion binding]; other site 718254001384 Predicted membrane protein [Function unknown]; Region: COG3162 718254001385 acetyl-CoA synthetase; Provisional; Region: PRK00174 718254001386 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 718254001387 active site 718254001388 CoA binding site [chemical binding]; other site 718254001389 acyl-activating enzyme (AAE) consensus motif; other site 718254001390 AMP binding site [chemical binding]; other site 718254001391 acetate binding site [chemical binding]; other site 718254001392 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 718254001393 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718254001394 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 718254001395 Sel1 repeat; Region: Sel1; cl02723 718254001396 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718254001397 molybdopterin cofactor binding site; other site 718254001398 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 718254001399 molybdopterin cofactor binding site; other site 718254001400 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718254001401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254001402 active site 718254001403 phosphorylation site [posttranslational modification] 718254001404 intermolecular recognition site; other site 718254001405 dimerization interface [polypeptide binding]; other site 718254001406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254001407 DNA binding site [nucleotide binding] 718254001408 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 718254001409 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718254001410 substrate binding site [chemical binding]; other site 718254001411 ATP binding site [chemical binding]; other site 718254001412 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 718254001413 intersubunit interface [polypeptide binding]; other site 718254001414 active site 718254001415 zinc binding site [ion binding]; other site 718254001416 Na+ binding site [ion binding]; other site 718254001417 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 718254001418 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254001419 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254001420 TM-ABC transporter signature motif; other site 718254001421 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 718254001422 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254001423 Walker A/P-loop; other site 718254001424 ATP binding site [chemical binding]; other site 718254001425 Q-loop/lid; other site 718254001426 ABC transporter signature motif; other site 718254001427 Walker B; other site 718254001428 D-loop; other site 718254001429 H-loop/switch region; other site 718254001430 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254001431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718254001432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254001433 dimerization interface [polypeptide binding]; other site 718254001434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254001435 dimer interface [polypeptide binding]; other site 718254001436 phosphorylation site [posttranslational modification] 718254001437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254001438 ATP binding site [chemical binding]; other site 718254001439 Mg2+ binding site [ion binding]; other site 718254001440 G-X-G motif; other site 718254001441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254001442 Response regulator receiver domain; Region: Response_reg; pfam00072 718254001443 active site 718254001444 phosphorylation site [posttranslational modification] 718254001445 intermolecular recognition site; other site 718254001446 dimerization interface [polypeptide binding]; other site 718254001447 D-allose kinase; Provisional; Region: PRK09698 718254001448 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718254001449 nucleotide binding site [chemical binding]; other site 718254001450 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 718254001451 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 718254001452 substrate binding site [chemical binding]; other site 718254001453 hexamer interface [polypeptide binding]; other site 718254001454 metal binding site [ion binding]; metal-binding site 718254001455 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 718254001456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254001457 Walker A/P-loop; other site 718254001458 ATP binding site [chemical binding]; other site 718254001459 Q-loop/lid; other site 718254001460 ABC transporter signature motif; other site 718254001461 Walker B; other site 718254001462 D-loop; other site 718254001463 H-loop/switch region; other site 718254001464 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254001465 D-allose transporter subunit; Provisional; Region: PRK09701 718254001466 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 718254001467 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 718254001468 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254001469 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254001470 putative active site [active] 718254001471 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 718254001472 putative hydrolase; Provisional; Region: PRK02113 718254001473 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 718254001474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254001475 Coenzyme A binding pocket [chemical binding]; other site 718254001476 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 718254001477 active site 718254001478 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 718254001479 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718254001480 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 718254001481 active site 718254001482 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 718254001483 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718254001484 Walker A/P-loop; other site 718254001485 ATP binding site [chemical binding]; other site 718254001486 Q-loop/lid; other site 718254001487 ABC transporter signature motif; other site 718254001488 Walker B; other site 718254001489 D-loop; other site 718254001490 H-loop/switch region; other site 718254001491 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 718254001492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254001493 Walker A/P-loop; other site 718254001494 ATP binding site [chemical binding]; other site 718254001495 Q-loop/lid; other site 718254001496 ABC transporter signature motif; other site 718254001497 Walker B; other site 718254001498 D-loop; other site 718254001499 H-loop/switch region; other site 718254001500 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718254001501 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 718254001502 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 718254001503 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 718254001504 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 718254001505 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 718254001506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254001507 DNA-binding site [nucleotide binding]; DNA binding site 718254001508 UTRA domain; Region: UTRA; pfam07702 718254001509 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 718254001510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254001511 dimer interface [polypeptide binding]; other site 718254001512 conserved gate region; other site 718254001513 putative PBP binding loops; other site 718254001514 ABC-ATPase subunit interface; other site 718254001515 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 718254001516 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 718254001517 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 718254001518 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 718254001519 Walker A/P-loop; other site 718254001520 ATP binding site [chemical binding]; other site 718254001521 Q-loop/lid; other site 718254001522 ABC transporter signature motif; other site 718254001523 Walker B; other site 718254001524 D-loop; other site 718254001525 H-loop/switch region; other site 718254001526 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 718254001527 dimer interface [polypeptide binding]; other site 718254001528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718254001529 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 718254001530 PhnA protein; Region: PhnA; pfam03831 718254001531 hypothetical protein; Provisional; Region: PRK09866 718254001532 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 718254001533 G1 box; other site 718254001534 GTP/Mg2+ binding site [chemical binding]; other site 718254001535 G2 box; other site 718254001536 Switch I region; other site 718254001537 G3 box; other site 718254001538 Switch II region; other site 718254001539 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 718254001540 G2 box; other site 718254001541 Switch I region; other site 718254001542 G3 box; other site 718254001543 Switch II region; other site 718254001544 G4 box; other site 718254001545 G5 box; other site 718254001546 YjcZ-like protein; Region: YjcZ; pfam13990 718254001547 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 718254001548 proline/glycine betaine transporter; Provisional; Region: PRK10642 718254001549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001550 putative substrate translocation pore; other site 718254001551 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 718254001552 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 718254001553 lipoprotein; Provisional; Region: PRK10397 718254001554 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 718254001555 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 718254001556 active site 718254001557 Na/Ca binding site [ion binding]; other site 718254001558 catalytic site [active] 718254001559 Flagellar protein FliT; Region: FliT; cl05125 718254001560 flagellar protein FliS; Validated; Region: fliS; PRK05685 718254001561 flagellar capping protein; Reviewed; Region: fliD; PRK08032 718254001562 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 718254001563 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 718254001564 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 718254001565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718254001566 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718254001567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718254001568 DNA binding residues [nucleotide binding] 718254001569 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 718254001570 cystine transporter subunit; Provisional; Region: PRK11260 718254001571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254001572 substrate binding pocket [chemical binding]; other site 718254001573 membrane-bound complex binding site; other site 718254001574 hinge residues; other site 718254001575 D-cysteine desulfhydrase; Validated; Region: PRK03910 718254001576 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 718254001577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254001578 catalytic residue [active] 718254001579 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718254001580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254001581 dimer interface [polypeptide binding]; other site 718254001582 conserved gate region; other site 718254001583 putative PBP binding loops; other site 718254001584 ABC-ATPase subunit interface; other site 718254001585 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 718254001586 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718254001587 Walker A/P-loop; other site 718254001588 ATP binding site [chemical binding]; other site 718254001589 Q-loop/lid; other site 718254001590 ABC transporter signature motif; other site 718254001591 Walker B; other site 718254001592 D-loop; other site 718254001593 H-loop/switch region; other site 718254001594 Autoinducer binding domain; Region: Autoind_bind; pfam03472 718254001595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254001596 DNA binding residues [nucleotide binding] 718254001597 dimerization interface [polypeptide binding]; other site 718254001598 hypothetical protein; Provisional; Region: PRK10613 718254001599 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 718254001600 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 718254001601 NAD(P) binding site [chemical binding]; other site 718254001602 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 718254001603 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 718254001604 potential catalytic triad [active] 718254001605 conserved cys residue [active] 718254001606 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 718254001607 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 718254001608 putative NAD(P) binding site [chemical binding]; other site 718254001609 putative active site [active] 718254001610 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 718254001611 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 718254001612 DNA binding residues [nucleotide binding] 718254001613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 718254001614 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718254001615 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 718254001616 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 718254001617 Walker A/P-loop; other site 718254001618 ATP binding site [chemical binding]; other site 718254001619 Q-loop/lid; other site 718254001620 ABC transporter signature motif; other site 718254001621 Walker B; other site 718254001622 D-loop; other site 718254001623 H-loop/switch region; other site 718254001624 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 718254001625 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 718254001626 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 718254001627 TM-ABC transporter signature motif; other site 718254001628 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254001629 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 718254001630 TM-ABC transporter signature motif; other site 718254001631 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 718254001632 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 718254001633 dimerization interface [polypeptide binding]; other site 718254001634 ligand binding site [chemical binding]; other site 718254001635 hypothetical protein; Provisional; Region: PRK10396 718254001636 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 718254001637 SEC-C motif; Region: SEC-C; pfam02810 718254001638 tyrosine transporter TyrP; Provisional; Region: PRK15132 718254001639 aromatic amino acid transport protein; Region: araaP; TIGR00837 718254001640 probable metal-binding protein; Region: matur_matur; TIGR03853 718254001641 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 718254001642 Ferritin-like domain; Region: Ferritin; pfam00210 718254001643 ferroxidase diiron center [ion binding]; other site 718254001644 YecR-like lipoprotein; Region: YecR; pfam13992 718254001645 hypothetical protein; Provisional; Region: PRK09273 718254001646 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 718254001647 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 718254001648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254001650 putative substrate translocation pore; other site 718254001651 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 718254001652 Ferritin-like domain; Region: Ferritin; pfam00210 718254001653 ferroxidase diiron center [ion binding]; other site 718254001654 DJ-1 family protein; Region: not_thiJ; TIGR01383 718254001655 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 718254001656 conserved cys residue [active] 718254001657 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 718254001658 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 718254001659 ligand binding site [chemical binding]; other site 718254001660 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 718254001661 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254001662 Walker A/P-loop; other site 718254001663 ATP binding site [chemical binding]; other site 718254001664 Q-loop/lid; other site 718254001665 ABC transporter signature motif; other site 718254001666 Walker B; other site 718254001667 D-loop; other site 718254001668 H-loop/switch region; other site 718254001669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254001670 Walker A/P-loop; other site 718254001671 ATP binding site [chemical binding]; other site 718254001672 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254001673 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254001674 TM-ABC transporter signature motif; other site 718254001675 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 718254001676 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 718254001677 active site 718254001678 homotetramer interface [polypeptide binding]; other site 718254001679 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718254001680 Ligand Binding Site [chemical binding]; other site 718254001681 transcriptional activator FlhD; Provisional; Region: PRK02909 718254001682 transcriptional activator FlhC; Provisional; Region: PRK12722 718254001683 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 718254001684 flagellar motor protein MotA; Validated; Region: PRK09110 718254001685 flagellar motor protein MotB; Validated; Region: motB; PRK09041 718254001686 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 718254001687 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718254001688 ligand binding site [chemical binding]; other site 718254001689 chemotaxis protein CheA; Provisional; Region: PRK10547 718254001690 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718254001691 putative binding surface; other site 718254001692 active site 718254001693 CheY binding; Region: CheY-binding; pfam09078 718254001694 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 718254001695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254001696 ATP binding site [chemical binding]; other site 718254001697 Mg2+ binding site [ion binding]; other site 718254001698 G-X-G motif; other site 718254001699 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 718254001700 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 718254001701 putative CheA interaction surface; other site 718254001702 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718254001703 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 718254001704 Spore Coat Protein U domain; Region: SCPU; pfam05229 718254001705 Spore Coat Protein U domain; Region: SCPU; pfam05229 718254001706 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254001707 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718254001708 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254001709 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254001710 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254001711 PapC C-terminal domain; Region: PapC_C; pfam13953 718254001712 methyl-accepting protein IV; Provisional; Region: PRK09793 718254001713 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718254001714 dimer interface [polypeptide binding]; other site 718254001715 ligand binding site [chemical binding]; other site 718254001716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254001717 dimerization interface [polypeptide binding]; other site 718254001718 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254001719 dimer interface [polypeptide binding]; other site 718254001720 putative CheW interface [polypeptide binding]; other site 718254001721 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 718254001722 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 718254001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254001724 S-adenosylmethionine binding site [chemical binding]; other site 718254001725 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 718254001726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254001727 active site 718254001728 phosphorylation site [posttranslational modification] 718254001729 intermolecular recognition site; other site 718254001730 dimerization interface [polypeptide binding]; other site 718254001731 CheB methylesterase; Region: CheB_methylest; pfam01339 718254001732 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 718254001733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254001734 active site 718254001735 phosphorylation site [posttranslational modification] 718254001736 intermolecular recognition site; other site 718254001737 dimerization interface [polypeptide binding]; other site 718254001738 chemotaxis regulator CheZ; Provisional; Region: PRK11166 718254001739 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 718254001740 FHIPEP family; Region: FHIPEP; pfam00771 718254001741 Flagellar protein FlhE; Region: FlhE; pfam06366 718254001742 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 718254001743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001744 putative substrate translocation pore; other site 718254001745 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 718254001746 putative metal binding site [ion binding]; other site 718254001747 Methyltransferase domain; Region: Methyltransf_23; pfam13489 718254001748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254001749 S-adenosylmethionine binding site [chemical binding]; other site 718254001750 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 718254001751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254001752 S-adenosylmethionine binding site [chemical binding]; other site 718254001753 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 718254001754 Protein of unknown function DUF72; Region: DUF72; cl00777 718254001755 Protein of unknown function DUF72; Region: DUF72; cl00777 718254001756 Isochorismatase family; Region: Isochorismatase; pfam00857 718254001757 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 718254001758 catalytic triad [active] 718254001759 conserved cis-peptide bond; other site 718254001760 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 718254001761 nudix motif; other site 718254001762 hypothetical protein; Validated; Region: PRK00110 718254001763 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 718254001764 active site 718254001765 putative DNA-binding cleft [nucleotide binding]; other site 718254001766 dimer interface [polypeptide binding]; other site 718254001767 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 718254001768 RuvA N terminal domain; Region: RuvA_N; pfam01330 718254001769 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 718254001770 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718254001771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254001772 ABC-ATPase subunit interface; other site 718254001773 dimer interface [polypeptide binding]; other site 718254001774 putative PBP binding regions; other site 718254001775 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 718254001776 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 718254001777 metal binding site [ion binding]; metal-binding site 718254001778 putative peptidase; Provisional; Region: PRK11649 718254001779 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 718254001780 Peptidase family M23; Region: Peptidase_M23; pfam01551 718254001781 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 718254001782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718254001783 putative acyl-acceptor binding pocket; other site 718254001784 pyruvate kinase; Provisional; Region: PRK05826 718254001785 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 718254001786 domain interfaces; other site 718254001787 active site 718254001788 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 718254001789 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254001790 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254001791 putative active site [active] 718254001792 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 718254001793 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 718254001794 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 718254001795 phosphogluconate dehydratase; Validated; Region: PRK09054 718254001796 6-phosphogluconate dehydratase; Region: edd; TIGR01196 718254001797 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 718254001798 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 718254001799 active site 718254001800 intersubunit interface [polypeptide binding]; other site 718254001801 catalytic residue [active] 718254001802 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 718254001803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254001804 ATP-grasp domain; Region: ATP-grasp; pfam02222 718254001805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 718254001806 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 718254001807 putative metal binding site [ion binding]; other site 718254001808 protease 2; Provisional; Region: PRK10115 718254001809 exodeoxyribonuclease X; Provisional; Region: PRK07983 718254001810 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 718254001811 active site 718254001812 catalytic site [active] 718254001813 substrate binding site [chemical binding]; other site 718254001814 Predicted amidohydrolase [General function prediction only]; Region: COG0388 718254001815 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 718254001816 CopC domain; Region: CopC; cl01012 718254001817 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 718254001818 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 718254001819 Protein of unknown function (DUF535); Region: DUF535; pfam04393 718254001820 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 718254001821 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 718254001822 active site 718254001823 metal binding site [ion binding]; metal-binding site 718254001824 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 718254001825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254001826 S-adenosylmethionine binding site [chemical binding]; other site 718254001827 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 718254001828 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 718254001829 Paraquat-inducible protein A; Region: PqiA; pfam04403 718254001830 Paraquat-inducible protein A; Region: PqiA; pfam04403 718254001831 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 718254001832 GAF domain; Region: GAF_2; pfam13185 718254001833 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 718254001834 ProQ/FINO family; Region: ProQ; pfam04352 718254001835 carboxy-terminal protease; Provisional; Region: PRK11186 718254001836 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 718254001837 protein binding site [polypeptide binding]; other site 718254001838 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 718254001839 Catalytic dyad [active] 718254001840 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 718254001841 heat shock protein HtpX; Provisional; Region: PRK05457 718254001842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254001844 putative substrate translocation pore; other site 718254001845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254001846 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 718254001847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254001848 dimerization interface [polypeptide binding]; other site 718254001849 putative Zn2+ binding site [ion binding]; other site 718254001850 putative DNA binding site [nucleotide binding]; other site 718254001851 Bacterial transcriptional regulator; Region: IclR; pfam01614 718254001852 YobH-like protein; Region: YobH; pfam13996 718254001853 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718254001854 DNA-binding site [nucleotide binding]; DNA binding site 718254001855 RNA-binding motif; other site 718254001856 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 718254001857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254001858 S-adenosylmethionine binding site [chemical binding]; other site 718254001859 hypothetical protein; Provisional; Region: PRK11469 718254001860 Domain of unknown function DUF; Region: DUF204; pfam02659 718254001861 Domain of unknown function DUF; Region: DUF204; pfam02659 718254001862 hypothetical protein; Provisional; Region: PRK02913 718254001863 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 718254001864 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 718254001865 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 718254001866 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 718254001867 active pocket/dimerization site; other site 718254001868 active site 718254001869 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 718254001870 active site 718254001871 phosphorylation site [posttranslational modification] 718254001872 phage resistance protein; Provisional; Region: PRK10551 718254001873 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 718254001874 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254001875 L-serine deaminase; Provisional; Region: PRK15023 718254001876 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 718254001877 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 718254001878 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 718254001879 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 718254001880 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 718254001881 hypothetical protein; Provisional; Region: PRK05114 718254001882 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 718254001883 homotrimer interaction site [polypeptide binding]; other site 718254001884 putative active site [active] 718254001885 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 718254001886 Glycoprotease family; Region: Peptidase_M22; pfam00814 718254001887 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 718254001888 ribonuclease D; Provisional; Region: PRK10829 718254001889 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 718254001890 catalytic site [active] 718254001891 putative active site [active] 718254001892 putative substrate binding site [chemical binding]; other site 718254001893 Helicase and RNase D C-terminal; Region: HRDC; smart00341 718254001894 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 718254001895 cell division inhibitor MinD; Provisional; Region: PRK10818 718254001896 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 718254001897 Switch I; other site 718254001898 Switch II; other site 718254001899 septum formation inhibitor; Reviewed; Region: minC; PRK03511 718254001900 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 718254001901 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 718254001902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 718254001903 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 718254001904 hypothetical protein; Provisional; Region: PRK10691 718254001905 hypothetical protein; Provisional; Region: PRK05170 718254001906 fatty acid metabolism regulator; Provisional; Region: PRK04984 718254001907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254001908 DNA-binding site [nucleotide binding]; DNA binding site 718254001909 FadR C-terminal domain; Region: FadR_C; pfam07840 718254001910 SpoVR family protein; Provisional; Region: PRK11767 718254001911 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 718254001912 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 718254001913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254001914 hydroxyglutarate oxidase; Provisional; Region: PRK11728 718254001915 alanine racemase; Reviewed; Region: dadX; PRK03646 718254001916 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 718254001917 active site 718254001918 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718254001919 substrate binding site [chemical binding]; other site 718254001920 catalytic residues [active] 718254001921 dimer interface [polypeptide binding]; other site 718254001922 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 718254001923 TrkA-C domain; Region: TrkA_C; pfam02080 718254001924 Transporter associated domain; Region: CorC_HlyC; smart01091 718254001925 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 718254001926 dimer interface [polypeptide binding]; other site 718254001927 catalytic triad [active] 718254001928 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 718254001929 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718254001930 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718254001931 catalytic residue [active] 718254001932 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 718254001933 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 718254001934 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 718254001935 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 718254001936 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 718254001937 conserved cys residue [active] 718254001938 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 718254001939 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 718254001940 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 718254001941 hypothetical protein; Provisional; Region: PRK07033 718254001942 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 718254001943 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718254001944 ligand binding site [chemical binding]; other site 718254001945 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 718254001946 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 718254001947 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 718254001948 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 718254001949 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 718254001950 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 718254001951 Protein of unknown function (DUF770); Region: DUF770; pfam05591 718254001952 Protein of unknown function (DUF796); Region: DUF796; pfam05638 718254001953 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 718254001954 phosphopeptide binding site; other site 718254001955 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 718254001956 active site 718254001957 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 718254001958 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 718254001959 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 718254001960 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 718254001961 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 718254001962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254001963 Walker A motif; other site 718254001964 ATP binding site [chemical binding]; other site 718254001965 Walker B motif; other site 718254001966 arginine finger; other site 718254001967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254001968 Walker A motif; other site 718254001969 ATP binding site [chemical binding]; other site 718254001970 Walker B motif; other site 718254001971 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718254001972 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 718254001973 Catalytic domain of Protein Kinases; Region: PKc; cd00180 718254001974 active site 718254001975 ATP binding site [chemical binding]; other site 718254001976 substrate binding site [chemical binding]; other site 718254001977 activation loop (A-loop); other site 718254001978 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 718254001979 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 718254001980 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 718254001981 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 718254001982 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 718254001983 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 718254001984 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 718254001985 GTP-binding protein YchF; Reviewed; Region: PRK09601 718254001986 YchF GTPase; Region: YchF; cd01900 718254001987 G1 box; other site 718254001988 GTP/Mg2+ binding site [chemical binding]; other site 718254001989 Switch I region; other site 718254001990 G2 box; other site 718254001991 Switch II region; other site 718254001992 G3 box; other site 718254001993 G4 box; other site 718254001994 G5 box; other site 718254001995 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 718254001996 hypothetical protein; Provisional; Region: PRK10692 718254001997 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 718254001998 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 718254001999 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718254002000 active site 718254002001 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 718254002002 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 718254002003 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 718254002004 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 718254002005 tRNA; other site 718254002006 putative tRNA binding site [nucleotide binding]; other site 718254002007 putative NADP binding site [chemical binding]; other site 718254002008 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 718254002009 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 718254002010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254002011 hypothetical protein; Provisional; Region: PRK10278 718254002012 hypothetical protein; Provisional; Region: PRK10941 718254002013 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 718254002014 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 718254002015 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 718254002016 cation transport regulator; Reviewed; Region: chaB; PRK09582 718254002017 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 718254002018 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 718254002019 putative active site pocket [active] 718254002020 dimerization interface [polypeptide binding]; other site 718254002021 putative catalytic residue [active] 718254002022 Cache domain; Region: Cache_1; pfam02743 718254002023 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 718254002024 Nitrate and nitrite sensing; Region: NIT; pfam08376 718254002025 ANTAR domain; Region: ANTAR; pfam03861 718254002026 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 718254002027 NMT1-like family; Region: NMT1_2; pfam13379 718254002028 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 718254002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002030 dimer interface [polypeptide binding]; other site 718254002031 conserved gate region; other site 718254002032 putative PBP binding loops; other site 718254002033 ABC-ATPase subunit interface; other site 718254002034 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 718254002035 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 718254002036 Walker A/P-loop; other site 718254002037 ATP binding site [chemical binding]; other site 718254002038 Q-loop/lid; other site 718254002039 ABC transporter signature motif; other site 718254002040 Walker B; other site 718254002041 D-loop; other site 718254002042 H-loop/switch region; other site 718254002043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 718254002044 nitrite reductase subunit NirD; Provisional; Region: PRK14989 718254002045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718254002046 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254002047 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 718254002048 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 718254002049 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 718254002050 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 718254002051 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 718254002052 [4Fe-4S] binding site [ion binding]; other site 718254002053 molybdopterin cofactor binding site; other site 718254002054 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 718254002055 molybdopterin cofactor binding site; other site 718254002056 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 718254002057 transcriptional regulator NarL; Provisional; Region: PRK10651 718254002058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254002059 active site 718254002060 phosphorylation site [posttranslational modification] 718254002061 intermolecular recognition site; other site 718254002062 dimerization interface [polypeptide binding]; other site 718254002063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254002064 DNA binding residues [nucleotide binding] 718254002065 dimerization interface [polypeptide binding]; other site 718254002066 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 718254002067 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 718254002068 4Fe-4S binding domain; Region: Fer4; cl02805 718254002069 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 718254002070 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 718254002071 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 718254002072 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 718254002073 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 718254002074 putative active site [active] 718254002075 putative substrate binding site [chemical binding]; other site 718254002076 putative cosubstrate binding site; other site 718254002077 catalytic site [active] 718254002078 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 718254002079 nucleophile elbow; other site 718254002080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254002081 active site 718254002082 response regulator of RpoS; Provisional; Region: PRK10693 718254002083 phosphorylation site [posttranslational modification] 718254002084 intermolecular recognition site; other site 718254002085 dimerization interface [polypeptide binding]; other site 718254002086 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 718254002087 tetramer interface; other site 718254002088 active site 718254002089 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 718254002090 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 718254002091 thymidine kinase; Provisional; Region: PRK04296 718254002092 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 718254002093 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 718254002094 putative catalytic cysteine [active] 718254002095 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 718254002096 putative active site [active] 718254002097 metal binding site [ion binding]; metal-binding site 718254002098 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 718254002099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002100 dimer interface [polypeptide binding]; other site 718254002101 conserved gate region; other site 718254002102 putative PBP binding loops; other site 718254002103 ABC-ATPase subunit interface; other site 718254002104 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 718254002105 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 718254002106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002107 dimer interface [polypeptide binding]; other site 718254002108 conserved gate region; other site 718254002109 putative PBP binding loops; other site 718254002110 ABC-ATPase subunit interface; other site 718254002111 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 718254002112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254002113 Walker A/P-loop; other site 718254002114 ATP binding site [chemical binding]; other site 718254002115 Q-loop/lid; other site 718254002116 ABC transporter signature motif; other site 718254002117 Walker B; other site 718254002118 D-loop; other site 718254002119 H-loop/switch region; other site 718254002120 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 718254002121 dsDNA-mimic protein; Reviewed; Region: PRK05094 718254002122 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 718254002123 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 718254002124 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 718254002125 putative active site [active] 718254002126 catalytic site [active] 718254002127 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 718254002128 putative active site [active] 718254002129 catalytic site [active] 718254002130 transport protein TonB; Provisional; Region: PRK10819 718254002131 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 718254002132 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 718254002133 intracellular septation protein A; Reviewed; Region: PRK00259 718254002134 hypothetical protein; Provisional; Region: PRK02868 718254002135 outer membrane protein W; Provisional; Region: PRK10959 718254002136 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 718254002137 CPxP motif; other site 718254002138 putative inner membrane protein; Provisional; Region: PRK11099 718254002139 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 718254002140 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 718254002141 substrate binding site [chemical binding]; other site 718254002142 active site 718254002143 catalytic residues [active] 718254002144 heterodimer interface [polypeptide binding]; other site 718254002145 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 718254002146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718254002147 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 718254002148 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 718254002149 active site 718254002150 ribulose/triose binding site [chemical binding]; other site 718254002151 phosphate binding site [ion binding]; other site 718254002152 substrate (anthranilate) binding pocket [chemical binding]; other site 718254002153 product (indole) binding pocket [chemical binding]; other site 718254002154 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 718254002155 active site 718254002156 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 718254002157 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 718254002158 glutamine binding [chemical binding]; other site 718254002159 catalytic triad [active] 718254002160 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 718254002161 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 718254002162 anthranilate synthase component I; Provisional; Region: PRK13564 718254002163 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 718254002164 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 718254002165 hypothetical protein; Provisional; Region: PRK11630 718254002166 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 718254002167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718254002168 RNA binding surface [nucleotide binding]; other site 718254002169 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 718254002170 probable active site [active] 718254002171 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 718254002172 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 718254002173 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 718254002174 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 718254002175 active site 718254002176 interdomain interaction site; other site 718254002177 putative metal-binding site [ion binding]; other site 718254002178 nucleotide binding site [chemical binding]; other site 718254002179 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 718254002180 domain I; other site 718254002181 DNA binding groove [nucleotide binding] 718254002182 phosphate binding site [ion binding]; other site 718254002183 domain II; other site 718254002184 domain III; other site 718254002185 nucleotide binding site [chemical binding]; other site 718254002186 catalytic site [active] 718254002187 domain IV; other site 718254002188 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718254002189 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718254002190 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 718254002191 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 718254002192 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 718254002193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002194 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 718254002195 substrate binding site [chemical binding]; other site 718254002196 putative dimerization interface [polypeptide binding]; other site 718254002197 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 718254002198 dimerization interface [polypeptide binding]; other site 718254002199 active site 718254002200 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 718254002201 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 718254002202 active site 718254002203 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 718254002204 active site 718254002205 dimer interface [polypeptide binding]; other site 718254002206 translation initiation factor Sui1; Validated; Region: PRK06824 718254002207 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 718254002208 putative rRNA binding site [nucleotide binding]; other site 718254002209 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718254002210 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 718254002211 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254002212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254002213 active site 718254002214 I-site; other site 718254002215 metal binding site [ion binding]; metal-binding site 718254002216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254002217 PAS domain; Region: PAS_9; pfam13426 718254002218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718254002219 putative active site [active] 718254002220 heme pocket [chemical binding]; other site 718254002221 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254002222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254002223 metal binding site [ion binding]; metal-binding site 718254002224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 718254002225 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 718254002226 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 718254002227 NAD binding site [chemical binding]; other site 718254002228 homotetramer interface [polypeptide binding]; other site 718254002229 homodimer interface [polypeptide binding]; other site 718254002230 substrate binding site [chemical binding]; other site 718254002231 active site 718254002232 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254002233 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254002234 metal binding site [ion binding]; metal-binding site 718254002235 active site 718254002236 I-site; other site 718254002237 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718254002238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254002239 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 718254002240 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 718254002241 homotrimer interaction site [polypeptide binding]; other site 718254002242 putative active site [active] 718254002243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718254002244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254002245 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 718254002246 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254002247 Walker A/P-loop; other site 718254002248 ATP binding site [chemical binding]; other site 718254002249 Q-loop/lid; other site 718254002250 ABC transporter signature motif; other site 718254002251 Walker B; other site 718254002252 D-loop; other site 718254002253 H-loop/switch region; other site 718254002254 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 718254002255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254002256 Walker A/P-loop; other site 718254002257 ATP binding site [chemical binding]; other site 718254002258 Q-loop/lid; other site 718254002259 ABC transporter signature motif; other site 718254002260 Walker B; other site 718254002261 D-loop; other site 718254002262 H-loop/switch region; other site 718254002263 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718254002264 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 718254002265 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 718254002266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002267 putative PBP binding loops; other site 718254002268 dimer interface [polypeptide binding]; other site 718254002269 ABC-ATPase subunit interface; other site 718254002270 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 718254002271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254002272 Walker A motif; other site 718254002273 ATP binding site [chemical binding]; other site 718254002274 Walker B motif; other site 718254002275 arginine finger; other site 718254002276 phage shock protein PspA; Provisional; Region: PRK10698 718254002277 phage shock protein B; Provisional; Region: pspB; PRK09458 718254002278 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 718254002279 phage shock protein C; Region: phageshock_pspC; TIGR02978 718254002280 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 718254002281 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 718254002282 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 718254002283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002284 dimer interface [polypeptide binding]; other site 718254002285 conserved gate region; other site 718254002286 putative PBP binding loops; other site 718254002287 ABC-ATPase subunit interface; other site 718254002288 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 718254002289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002290 dimer interface [polypeptide binding]; other site 718254002291 conserved gate region; other site 718254002292 putative PBP binding loops; other site 718254002293 ABC-ATPase subunit interface; other site 718254002294 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 718254002295 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 718254002296 putative NAD(P) binding site [chemical binding]; other site 718254002297 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 718254002298 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 718254002299 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 718254002300 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 718254002301 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 718254002302 beta-phosphoglucomutase; Region: bPGM; TIGR01990 718254002303 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 718254002304 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 718254002305 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 718254002306 Walker A/P-loop; other site 718254002307 ATP binding site [chemical binding]; other site 718254002308 Q-loop/lid; other site 718254002309 ABC transporter signature motif; other site 718254002310 Walker B; other site 718254002311 D-loop; other site 718254002312 H-loop/switch region; other site 718254002313 TOBE domain; Region: TOBE_2; pfam08402 718254002314 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 718254002315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254002316 hypothetical protein; Provisional; Region: PRK05415 718254002317 Domain of unknown function (DUF697); Region: DUF697; cl12064 718254002318 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 718254002319 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 718254002320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718254002321 putative active site [active] 718254002322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254002323 Walker A motif; other site 718254002324 ATP binding site [chemical binding]; other site 718254002325 Walker B motif; other site 718254002326 arginine finger; other site 718254002327 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 718254002328 dimer interface [polypeptide binding]; other site 718254002329 catalytic triad [active] 718254002330 peroxidatic and resolving cysteines [active] 718254002331 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 718254002332 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 718254002333 active site 718254002334 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 718254002335 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 718254002336 putative active site [active] 718254002337 Zn binding site [ion binding]; other site 718254002338 Protein of unknown function (DUF770); Region: DUF770; pfam05591 718254002339 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 718254002340 Protein of unknown function (DUF877); Region: DUF877; pfam05943 718254002341 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 718254002342 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 718254002343 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 718254002344 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 718254002345 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718254002346 ligand binding site [chemical binding]; other site 718254002347 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 718254002348 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 718254002349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254002350 Walker A motif; other site 718254002351 ATP binding site [chemical binding]; other site 718254002352 Walker B motif; other site 718254002353 arginine finger; other site 718254002354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254002355 Walker A motif; other site 718254002356 ATP binding site [chemical binding]; other site 718254002357 Walker B motif; other site 718254002358 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718254002359 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 718254002360 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 718254002361 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 718254002362 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 718254002363 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 718254002364 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 718254002365 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 718254002366 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 718254002367 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 718254002368 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 718254002369 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 718254002370 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 718254002371 putative RNA binding site [nucleotide binding]; other site 718254002372 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 718254002373 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 718254002374 Ligand Binding Site [chemical binding]; other site 718254002375 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 718254002376 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254002377 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718254002378 trimer interface [polypeptide binding]; other site 718254002379 eyelet of channel; other site 718254002380 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 718254002381 dimer interface [polypeptide binding]; other site 718254002382 PYR/PP interface [polypeptide binding]; other site 718254002383 TPP binding site [chemical binding]; other site 718254002384 substrate binding site [chemical binding]; other site 718254002385 META domain; Region: META; cl01245 718254002386 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 718254002387 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 718254002388 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 718254002389 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 718254002390 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 718254002391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254002392 DNA-binding site [nucleotide binding]; DNA binding site 718254002393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254002394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254002395 homodimer interface [polypeptide binding]; other site 718254002396 catalytic residue [active] 718254002397 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 718254002398 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 718254002399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 718254002400 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 718254002401 Virulence factor SrfB; Region: SrfB; pfam07520 718254002402 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718254002403 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 718254002404 peptide binding site [polypeptide binding]; other site 718254002405 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 718254002406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 718254002407 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 718254002408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254002409 Coenzyme A binding pocket [chemical binding]; other site 718254002410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 718254002411 sequence-specific DNA binding site [nucleotide binding]; other site 718254002412 salt bridge; other site 718254002413 Cupin domain; Region: Cupin_2; pfam07883 718254002414 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718254002415 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 718254002416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254002417 DNA-binding site [nucleotide binding]; DNA binding site 718254002418 FCD domain; Region: FCD; pfam07729 718254002419 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 718254002420 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254002421 N-terminal plug; other site 718254002422 ligand-binding site [chemical binding]; other site 718254002423 PQQ-like domain; Region: PQQ_2; pfam13360 718254002424 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 718254002425 L-asparagine permease; Provisional; Region: PRK15049 718254002426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254002427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002428 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 718254002429 putative effector binding pocket; other site 718254002430 putative dimerization interface [polypeptide binding]; other site 718254002431 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 718254002432 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 718254002433 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 718254002434 metal binding site [ion binding]; metal-binding site 718254002435 dimer interface [polypeptide binding]; other site 718254002436 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 718254002437 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 718254002438 active site 718254002439 non-prolyl cis peptide bond; other site 718254002440 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 718254002441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254002442 substrate binding pocket [chemical binding]; other site 718254002443 membrane-bound complex binding site; other site 718254002444 hinge residues; other site 718254002445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254002446 Coenzyme A binding pocket [chemical binding]; other site 718254002447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002448 dimer interface [polypeptide binding]; other site 718254002449 conserved gate region; other site 718254002450 putative PBP binding loops; other site 718254002451 ABC-ATPase subunit interface; other site 718254002452 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 718254002453 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 718254002454 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718254002455 putative acyl-acceptor binding pocket; other site 718254002456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254002457 dimerization interface [polypeptide binding]; other site 718254002458 putative DNA binding site [nucleotide binding]; other site 718254002459 putative Zn2+ binding site [ion binding]; other site 718254002460 elongation factor G; Reviewed; Region: PRK00007 718254002461 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 718254002462 G1 box; other site 718254002463 putative GEF interaction site [polypeptide binding]; other site 718254002464 GTP/Mg2+ binding site [chemical binding]; other site 718254002465 Switch I region; other site 718254002466 G2 box; other site 718254002467 G3 box; other site 718254002468 Switch II region; other site 718254002469 G4 box; other site 718254002470 G5 box; other site 718254002471 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 718254002472 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 718254002473 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 718254002474 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 718254002475 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 718254002476 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 718254002477 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 718254002478 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 718254002479 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 718254002480 TetR family transcriptional regulator; Provisional; Region: PRK14996 718254002481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254002482 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 718254002483 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254002484 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718254002485 trimer interface [polypeptide binding]; other site 718254002486 eyelet of channel; other site 718254002487 aromatic amino acid exporter; Provisional; Region: PRK11689 718254002488 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718254002489 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 718254002490 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 718254002491 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 718254002492 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 718254002493 CcdB protein; Region: CcdB; cl03380 718254002494 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 718254002495 MFS transport protein AraJ; Provisional; Region: PRK10091 718254002496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254002497 putative substrate translocation pore; other site 718254002498 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 718254002499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254002500 Predicted transcriptional regulator [Transcription]; Region: COG1959 718254002501 Transcriptional regulator; Region: Rrf2; pfam02082 718254002502 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718254002503 malate dehydrogenase; Provisional; Region: PRK13529 718254002504 Malic enzyme, N-terminal domain; Region: malic; pfam00390 718254002505 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 718254002506 NAD(P) binding site [chemical binding]; other site 718254002507 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 718254002508 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 718254002509 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718254002510 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 718254002511 active site 718254002512 metal binding site [ion binding]; metal-binding site 718254002513 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 718254002514 transcriptional regulator; Provisional; Region: PRK10632 718254002515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002516 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 718254002517 putative effector binding pocket; other site 718254002518 dimerization interface [polypeptide binding]; other site 718254002519 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 718254002520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254002521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002522 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 718254002523 putative effector binding pocket; other site 718254002524 putative dimerization interface [polypeptide binding]; other site 718254002525 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 718254002526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254002527 Walker A/P-loop; other site 718254002528 ATP binding site [chemical binding]; other site 718254002529 Q-loop/lid; other site 718254002530 ABC transporter signature motif; other site 718254002531 Walker B; other site 718254002532 D-loop; other site 718254002533 H-loop/switch region; other site 718254002534 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718254002535 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 718254002536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254002537 Walker A/P-loop; other site 718254002538 ATP binding site [chemical binding]; other site 718254002539 Q-loop/lid; other site 718254002540 ABC transporter signature motif; other site 718254002541 Walker B; other site 718254002542 D-loop; other site 718254002543 H-loop/switch region; other site 718254002544 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718254002545 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718254002546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002547 dimer interface [polypeptide binding]; other site 718254002548 conserved gate region; other site 718254002549 putative PBP binding loops; other site 718254002550 ABC-ATPase subunit interface; other site 718254002551 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718254002552 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 718254002553 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 718254002554 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 718254002555 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254002556 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 718254002557 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 718254002558 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718254002559 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 718254002560 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 718254002561 substrate binding [chemical binding]; other site 718254002562 active site 718254002563 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 718254002564 Tar ligand binding domain homologue; Region: TarH; pfam02203 718254002565 ligand binding site [chemical binding]; other site 718254002566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254002567 dimerization interface [polypeptide binding]; other site 718254002568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254002569 dimer interface [polypeptide binding]; other site 718254002570 putative CheW interface [polypeptide binding]; other site 718254002571 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 718254002572 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 718254002573 dimerization domain [polypeptide binding]; other site 718254002574 dimer interface [polypeptide binding]; other site 718254002575 catalytic residues [active] 718254002576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 718254002577 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 718254002578 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 718254002579 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 718254002580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002581 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 718254002582 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 718254002583 dimerization interface [polypeptide binding]; other site 718254002584 substrate binding pocket [chemical binding]; other site 718254002585 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 718254002586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002587 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 718254002588 substrate binding pocket [chemical binding]; other site 718254002589 dimerization interface [polypeptide binding]; other site 718254002590 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 718254002591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002592 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 718254002593 dimerization interface [polypeptide binding]; other site 718254002594 substrate binding pocket [chemical binding]; other site 718254002595 SnoaL-like domain; Region: SnoaL_4; pfam13577 718254002596 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 718254002597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254002598 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 718254002599 NAD(P) binding site [chemical binding]; other site 718254002600 active site 718254002601 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 718254002602 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 718254002603 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 718254002604 catalytic site [active] 718254002605 active site 718254002606 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 718254002607 MarR family; Region: MarR_2; cl17246 718254002608 Protein of unknown function (DUF969); Region: DUF969; pfam06149 718254002609 Predicted membrane protein [Function unknown]; Region: COG3817 718254002610 Protein of unknown function (DUF979); Region: DUF979; pfam06166 718254002611 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 718254002612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254002613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254002614 putative substrate translocation pore; other site 718254002615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254002616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002617 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 718254002618 putative substrate binding pocket [chemical binding]; other site 718254002619 putative dimerization interface [polypeptide binding]; other site 718254002620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 718254002621 Winged helix-turn helix; Region: HTH_29; pfam13551 718254002622 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 718254002623 RNA binding site [nucleotide binding]; other site 718254002624 Predicted membrane protein [Function unknown]; Region: COG2323 718254002625 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 718254002626 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718254002627 dimer interface [polypeptide binding]; other site 718254002628 ADP-ribose binding site [chemical binding]; other site 718254002629 active site 718254002630 nudix motif; other site 718254002631 metal binding site [ion binding]; metal-binding site 718254002632 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 718254002633 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718254002634 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 718254002635 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254002636 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 718254002637 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 718254002638 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 718254002639 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718254002640 catalytic residues [active] 718254002641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 718254002642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254002643 dimer interface [polypeptide binding]; other site 718254002644 phosphorylation site [posttranslational modification] 718254002645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254002646 ATP binding site [chemical binding]; other site 718254002647 Mg2+ binding site [ion binding]; other site 718254002648 G-X-G motif; other site 718254002649 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 718254002650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 718254002651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 718254002652 Predicted membrane protein [Function unknown]; Region: COG3781 718254002653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 718254002654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 718254002655 GAF domain; Region: GAF; pfam01590 718254002656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254002657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254002658 metal binding site [ion binding]; metal-binding site 718254002659 active site 718254002660 I-site; other site 718254002661 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 718254002662 glutaminase; Provisional; Region: PRK00971 718254002663 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 718254002664 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718254002665 dimer interface [polypeptide binding]; other site 718254002666 ligand binding site [chemical binding]; other site 718254002667 HAMP domain; Region: HAMP; pfam00672 718254002668 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 718254002669 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254002670 dimer interface [polypeptide binding]; other site 718254002671 putative CheW interface [polypeptide binding]; other site 718254002672 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 718254002673 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 718254002674 NAD(P) binding site [chemical binding]; other site 718254002675 catalytic residues [active] 718254002676 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 718254002677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002678 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 718254002679 putative dimerization interface [polypeptide binding]; other site 718254002680 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 718254002681 putative arabinose transporter; Provisional; Region: PRK03545 718254002682 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 718254002683 MarC family integral membrane protein; Region: MarC; cl00919 718254002684 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 718254002685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254002686 MarB protein; Region: MarB; pfam13999 718254002687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254002688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254002689 putative substrate translocation pore; other site 718254002690 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 718254002691 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 718254002692 Walker A/P-loop; other site 718254002693 ATP binding site [chemical binding]; other site 718254002694 Q-loop/lid; other site 718254002695 ABC transporter signature motif; other site 718254002696 Walker B; other site 718254002697 D-loop; other site 718254002698 H-loop/switch region; other site 718254002699 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 718254002700 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 718254002701 Walker A/P-loop; other site 718254002702 ATP binding site [chemical binding]; other site 718254002703 Q-loop/lid; other site 718254002704 ABC transporter signature motif; other site 718254002705 Walker B; other site 718254002706 D-loop; other site 718254002707 H-loop/switch region; other site 718254002708 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 718254002709 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 718254002710 TM-ABC transporter signature motif; other site 718254002711 HEAT repeats; Region: HEAT_2; pfam13646 718254002712 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 718254002713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254002714 TM-ABC transporter signature motif; other site 718254002715 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 718254002716 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 718254002717 putative ligand binding site [chemical binding]; other site 718254002718 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 718254002719 substrate binding site [chemical binding]; other site 718254002720 THF binding site; other site 718254002721 zinc-binding site [ion binding]; other site 718254002722 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 718254002723 active site residue [active] 718254002724 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 718254002725 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 718254002726 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 718254002727 Peptidase family U32; Region: Peptidase_U32; pfam01136 718254002728 Collagenase; Region: DUF3656; pfam12392 718254002729 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 718254002730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254002731 non-specific DNA binding site [nucleotide binding]; other site 718254002732 salt bridge; other site 718254002733 sequence-specific DNA binding site [nucleotide binding]; other site 718254002734 Cupin domain; Region: Cupin_2; pfam07883 718254002735 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 718254002736 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718254002737 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 718254002738 peptide binding site [polypeptide binding]; other site 718254002739 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 718254002740 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 718254002741 metal binding site [ion binding]; metal-binding site 718254002742 dimer interface [polypeptide binding]; other site 718254002743 tellurite resistance protein TehB; Provisional; Region: PRK11207 718254002744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254002745 S-adenosylmethionine binding site [chemical binding]; other site 718254002746 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 718254002747 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 718254002748 gating phenylalanine in ion channel; other site 718254002749 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 718254002750 putative trimer interface [polypeptide binding]; other site 718254002751 putative CoA binding site [chemical binding]; other site 718254002752 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 718254002753 putative trimer interface [polypeptide binding]; other site 718254002754 putative CoA binding site [chemical binding]; other site 718254002755 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 718254002756 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 718254002757 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 718254002758 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 718254002759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254002760 substrate binding pocket [chemical binding]; other site 718254002761 membrane-bound complex binding site; other site 718254002762 hinge residues; other site 718254002763 putative aminotransferase; Provisional; Region: PRK12414 718254002764 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254002765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254002766 homodimer interface [polypeptide binding]; other site 718254002767 catalytic residue [active] 718254002768 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 718254002769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002770 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254002771 dimerization interface [polypeptide binding]; other site 718254002772 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 718254002773 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 718254002774 substrate binding pocket [chemical binding]; other site 718254002775 catalytic triad [active] 718254002776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 718254002777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 718254002778 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 718254002779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254002781 dimerization interface [polypeptide binding]; other site 718254002782 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718254002783 NAD(P) binding site [chemical binding]; other site 718254002784 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 718254002785 putative metal binding site [ion binding]; other site 718254002786 putative homodimer interface [polypeptide binding]; other site 718254002787 putative homotetramer interface [polypeptide binding]; other site 718254002788 putative homodimer-homodimer interface [polypeptide binding]; other site 718254002789 putative allosteric switch controlling residues; other site 718254002790 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 718254002791 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254002792 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 718254002793 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 718254002794 putative active site [active] 718254002795 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718254002796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254002797 Walker A/P-loop; other site 718254002798 ATP binding site [chemical binding]; other site 718254002799 Q-loop/lid; other site 718254002800 ABC transporter signature motif; other site 718254002801 Walker B; other site 718254002802 D-loop; other site 718254002803 H-loop/switch region; other site 718254002804 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718254002805 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 718254002806 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254002807 cytochrome b561; Provisional; Region: PRK11513 718254002808 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 718254002809 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 718254002810 NAD binding site [chemical binding]; other site 718254002811 catalytic residues [active] 718254002812 substrate binding site [chemical binding]; other site 718254002813 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 718254002814 Uncharacterized conserved protein [Function unknown]; Region: COG1434 718254002815 putative active site [active] 718254002816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254002817 putative substrate translocation pore; other site 718254002818 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 718254002819 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 718254002820 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254002821 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254002822 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 718254002823 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 718254002824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718254002825 azoreductase; Reviewed; Region: PRK00170 718254002826 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 718254002827 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718254002828 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718254002829 active site 718254002830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 718254002831 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 718254002832 methionine synthase; Provisional; Region: PRK01207 718254002833 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 718254002834 substrate binding site [chemical binding]; other site 718254002835 THF binding site; other site 718254002836 zinc-binding site [ion binding]; other site 718254002837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254002838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002839 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 718254002840 putative effector binding pocket; other site 718254002841 dimerization interface [polypeptide binding]; other site 718254002842 Protein of unknown function, DUF606; Region: DUF606; pfam04657 718254002843 Protein of unknown function, DUF606; Region: DUF606; pfam04657 718254002844 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 718254002845 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 718254002846 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 718254002847 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 718254002848 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 718254002849 SCP-2 sterol transfer family; Region: SCP2; pfam02036 718254002850 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 718254002851 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 718254002852 putative trimer interface [polypeptide binding]; other site 718254002853 putative metal binding site [ion binding]; other site 718254002854 PaaX-like protein; Region: PaaX; pfam07848 718254002855 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 718254002856 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 718254002857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718254002858 CoA binding site [chemical binding]; other site 718254002859 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718254002860 acyl-activating enzyme (AAE) consensus motif; other site 718254002861 CoA binding site [chemical binding]; other site 718254002862 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 718254002863 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 718254002864 dimer interface [polypeptide binding]; other site 718254002865 active site 718254002866 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 718254002867 CoenzymeA binding site [chemical binding]; other site 718254002868 subunit interaction site [polypeptide binding]; other site 718254002869 PHB binding site; other site 718254002870 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 718254002871 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 718254002872 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 718254002873 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 718254002874 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 718254002875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 718254002876 substrate binding site [chemical binding]; other site 718254002877 oxyanion hole (OAH) forming residues; other site 718254002878 trimer interface [polypeptide binding]; other site 718254002879 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 718254002880 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 718254002881 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 718254002882 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 718254002883 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 718254002884 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 718254002885 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254002886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254002887 metal binding site [ion binding]; metal-binding site 718254002888 active site 718254002889 I-site; other site 718254002890 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 718254002891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254002892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 718254002893 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 718254002894 hypothetical protein; Provisional; Region: PRK10695 718254002895 GnsA/GnsB family; Region: GnsAB; pfam08178 718254002896 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718254002897 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 718254002898 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 718254002899 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718254002900 DinI-like family; Region: DinI; pfam06183 718254002901 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718254002902 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 718254002903 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 718254002904 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254002905 N-terminal plug; other site 718254002906 ligand-binding site [chemical binding]; other site 718254002907 PQQ-like domain; Region: PQQ_2; pfam13360 718254002908 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 718254002909 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 718254002910 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 718254002911 active site 718254002912 Zn binding site [ion binding]; other site 718254002913 malonic semialdehyde reductase; Provisional; Region: PRK10538 718254002914 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 718254002915 putative NAD(P) binding site [chemical binding]; other site 718254002916 homodimer interface [polypeptide binding]; other site 718254002917 homotetramer interface [polypeptide binding]; other site 718254002918 active site 718254002919 Transcriptional regulators [Transcription]; Region: GntR; COG1802 718254002920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254002921 DNA-binding site [nucleotide binding]; DNA binding site 718254002922 FCD domain; Region: FCD; pfam07729 718254002923 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718254002924 Ligand Binding Site [chemical binding]; other site 718254002925 YdfZ protein; Region: YdfZ; pfam14001 718254002926 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 718254002927 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 718254002928 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 718254002929 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 718254002930 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 718254002931 Glucuronate isomerase; Region: UxaC; cl00829 718254002932 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 718254002933 Glucuronate isomerase; Region: UxaC; cl00829 718254002934 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 718254002935 putative oxidoreductase; Provisional; Region: PRK10083 718254002936 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 718254002937 putative NAD(P) binding site [chemical binding]; other site 718254002938 catalytic Zn binding site [ion binding]; other site 718254002939 structural Zn binding site [ion binding]; other site 718254002940 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 718254002941 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 718254002942 putative active site pocket [active] 718254002943 putative metal binding site [ion binding]; other site 718254002944 hypothetical protein; Provisional; Region: PRK02237 718254002945 hypothetical protein; Provisional; Region: PRK13659 718254002946 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 718254002947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254002948 Coenzyme A binding pocket [chemical binding]; other site 718254002949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 718254002950 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 718254002951 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 718254002952 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 718254002953 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 718254002954 putative [Fe4-S4] binding site [ion binding]; other site 718254002955 putative molybdopterin cofactor binding site [chemical binding]; other site 718254002956 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 718254002957 putative molybdopterin cofactor binding site; other site 718254002958 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 718254002959 YebG protein; Region: YebG; pfam07130 718254002960 Chloramphenicol acetyltransferase; Region: CAT; cl02008 718254002961 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 718254002962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254002963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002964 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 718254002965 putative effector binding pocket; other site 718254002966 putative dimerization interface [polypeptide binding]; other site 718254002967 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 718254002968 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 718254002969 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 718254002970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254002971 putative substrate translocation pore; other site 718254002972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002973 dimer interface [polypeptide binding]; other site 718254002974 conserved gate region; other site 718254002975 putative PBP binding loops; other site 718254002976 ABC-ATPase subunit interface; other site 718254002977 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 718254002978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254002979 dimer interface [polypeptide binding]; other site 718254002980 conserved gate region; other site 718254002981 ABC-ATPase subunit interface; other site 718254002982 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 718254002983 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 718254002984 Walker A/P-loop; other site 718254002985 ATP binding site [chemical binding]; other site 718254002986 Q-loop/lid; other site 718254002987 ABC transporter signature motif; other site 718254002988 Walker B; other site 718254002989 D-loop; other site 718254002990 H-loop/switch region; other site 718254002991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 718254002992 putative dithiobiotin synthetase; Provisional; Region: PRK12374 718254002993 AAA domain; Region: AAA_26; pfam13500 718254002994 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 718254002995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254002996 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 718254002997 dimerization interface [polypeptide binding]; other site 718254002998 substrate binding pocket [chemical binding]; other site 718254002999 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 718254003000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254003001 putative substrate translocation pore; other site 718254003002 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 718254003003 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 718254003004 active site 718254003005 Zn binding site [ion binding]; other site 718254003006 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 718254003007 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 718254003008 Domain of unknown function DUF20; Region: UPF0118; pfam01594 718254003009 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 718254003010 active site 718254003011 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 718254003012 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 718254003013 active site 718254003014 dimer interface [polypeptide binding]; other site 718254003015 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 718254003016 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 718254003017 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 718254003018 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 718254003019 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 718254003020 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 718254003021 Trp docking motif [polypeptide binding]; other site 718254003022 putative active site [active] 718254003023 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254003024 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254003025 active site 718254003026 catalytic tetrad [active] 718254003027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 718254003028 Smr domain; Region: Smr; pfam01713 718254003029 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 718254003030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254003031 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 718254003032 putative substrate binding pocket [chemical binding]; other site 718254003033 putative dimerization interface [polypeptide binding]; other site 718254003034 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 718254003035 amidohydrolase; Region: amidohydrolases; TIGR01891 718254003036 putative metal binding site [ion binding]; other site 718254003037 dimer interface [polypeptide binding]; other site 718254003038 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 718254003039 amidohydrolase; Region: amidohydrolases; TIGR01891 718254003040 putative metal binding site [ion binding]; other site 718254003041 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 718254003042 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 718254003043 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 718254003044 DNA binding site [nucleotide binding] 718254003045 active site 718254003046 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 718254003047 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 718254003048 ligand binding site [chemical binding]; other site 718254003049 flexible hinge region; other site 718254003050 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 718254003051 putative switch regulator; other site 718254003052 non-specific DNA interactions [nucleotide binding]; other site 718254003053 DNA binding site [nucleotide binding] 718254003054 sequence specific DNA binding site [nucleotide binding]; other site 718254003055 putative cAMP binding site [chemical binding]; other site 718254003056 universal stress protein UspE; Provisional; Region: PRK11175 718254003057 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718254003058 Ligand Binding Site [chemical binding]; other site 718254003059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718254003060 Ligand Binding Site [chemical binding]; other site 718254003061 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718254003062 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718254003063 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 718254003064 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 718254003065 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 718254003066 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 718254003067 ligand binding site [chemical binding]; other site 718254003068 homodimer interface [polypeptide binding]; other site 718254003069 NAD(P) binding site [chemical binding]; other site 718254003070 trimer interface B [polypeptide binding]; other site 718254003071 trimer interface A [polypeptide binding]; other site 718254003072 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 718254003073 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718254003074 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718254003075 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 718254003076 GlpM protein; Region: GlpM; pfam06942 718254003077 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 718254003078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254003079 active site 718254003080 phosphorylation site [posttranslational modification] 718254003081 intermolecular recognition site; other site 718254003082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254003083 DNA binding site [nucleotide binding] 718254003084 anti-adapter protein IraM; Provisional; Region: PRK09919 718254003085 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718254003086 DNA-binding site [nucleotide binding]; DNA binding site 718254003087 RNA-binding motif; other site 718254003088 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 718254003089 fumarate hydratase; Reviewed; Region: fumC; PRK00485 718254003090 Class II fumarases; Region: Fumarase_classII; cd01362 718254003091 active site 718254003092 tetramer interface [polypeptide binding]; other site 718254003093 fumarate hydratase; Provisional; Region: PRK15389 718254003094 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 718254003095 Fumarase C-terminus; Region: Fumerase_C; pfam05683 718254003096 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 718254003097 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 718254003098 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 718254003099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 718254003100 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 718254003101 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 718254003102 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 718254003103 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254003104 active site turn [active] 718254003105 phosphorylation site [posttranslational modification] 718254003106 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 718254003107 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254003108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254003109 homodimer interface [polypeptide binding]; other site 718254003110 catalytic residue [active] 718254003111 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 718254003112 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 718254003113 active site 718254003114 purine riboside binding site [chemical binding]; other site 718254003115 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 718254003116 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 718254003117 electron transport complex protein RsxA; Provisional; Region: PRK05151 718254003118 electron transport complex protein RnfB; Provisional; Region: PRK05113 718254003119 Putative Fe-S cluster; Region: FeS; cl17515 718254003120 4Fe-4S binding domain; Region: Fer4; pfam00037 718254003121 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 718254003122 SLBB domain; Region: SLBB; pfam10531 718254003123 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718254003124 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 718254003125 electron transport complex protein RnfG; Validated; Region: PRK01908 718254003126 electron transport complex RsxE subunit; Provisional; Region: PRK12405 718254003127 endonuclease III; Provisional; Region: PRK10702 718254003128 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718254003129 minor groove reading motif; other site 718254003130 helix-hairpin-helix signature motif; other site 718254003131 substrate binding pocket [chemical binding]; other site 718254003132 active site 718254003133 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 718254003134 glutathionine S-transferase; Provisional; Region: PRK10542 718254003135 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 718254003136 C-terminal domain interface [polypeptide binding]; other site 718254003137 GSH binding site (G-site) [chemical binding]; other site 718254003138 dimer interface [polypeptide binding]; other site 718254003139 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 718254003140 N-terminal domain interface [polypeptide binding]; other site 718254003141 dimer interface [polypeptide binding]; other site 718254003142 substrate binding pocket (H-site) [chemical binding]; other site 718254003143 pyridoxamine kinase; Validated; Region: PRK05756 718254003144 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 718254003145 dimer interface [polypeptide binding]; other site 718254003146 pyridoxal binding site [chemical binding]; other site 718254003147 ATP binding site [chemical binding]; other site 718254003148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718254003149 RNA binding surface [nucleotide binding]; other site 718254003150 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 718254003151 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 718254003152 active site 718254003153 HIGH motif; other site 718254003154 dimer interface [polypeptide binding]; other site 718254003155 KMSKS motif; other site 718254003156 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 718254003157 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 718254003158 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 718254003159 lysozyme inhibitor; Provisional; Region: PRK11372 718254003160 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 718254003161 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 718254003162 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 718254003163 transcriptional regulator SlyA; Provisional; Region: PRK03573 718254003164 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 718254003165 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 718254003166 Fusaric acid resistance protein family; Region: FUSC; pfam04632 718254003167 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718254003168 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 718254003169 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 718254003170 E-class dimer interface [polypeptide binding]; other site 718254003171 P-class dimer interface [polypeptide binding]; other site 718254003172 active site 718254003173 Cu2+ binding site [ion binding]; other site 718254003174 Zn2+ binding site [ion binding]; other site 718254003175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254003176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254003177 active site 718254003178 catalytic tetrad [active] 718254003179 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 718254003180 putative metal dependent hydrolase; Provisional; Region: PRK11598 718254003181 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 718254003182 Sulfatase; Region: Sulfatase; pfam00884 718254003183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718254003184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254003185 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 718254003186 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 718254003187 FMN binding site [chemical binding]; other site 718254003188 active site 718254003189 substrate binding site [chemical binding]; other site 718254003190 catalytic residue [active] 718254003191 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 718254003192 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718254003193 dimer interface [polypeptide binding]; other site 718254003194 active site 718254003195 glutathione binding site [chemical binding]; other site 718254003196 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 718254003197 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 718254003198 dimer interface [polypeptide binding]; other site 718254003199 catalytic site [active] 718254003200 putative active site [active] 718254003201 putative substrate binding site [chemical binding]; other site 718254003202 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 718254003203 putative GSH binding site [chemical binding]; other site 718254003204 catalytic residues [active] 718254003205 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 718254003206 NlpC/P60 family; Region: NLPC_P60; pfam00877 718254003207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254003208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254003209 putative substrate translocation pore; other site 718254003210 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 718254003211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254003212 DNA binding site [nucleotide binding] 718254003213 domain linker motif; other site 718254003214 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 718254003215 dimerization interface [polypeptide binding]; other site 718254003216 ligand binding site [chemical binding]; other site 718254003217 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 718254003218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254003219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254003220 dimerization interface [polypeptide binding]; other site 718254003221 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 718254003222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718254003223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254003224 S-adenosylmethionine binding site [chemical binding]; other site 718254003225 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 718254003226 Lumazine binding domain; Region: Lum_binding; pfam00677 718254003227 Lumazine binding domain; Region: Lum_binding; pfam00677 718254003228 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 718254003229 multidrug efflux protein; Reviewed; Region: PRK01766 718254003230 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 718254003231 cation binding site [ion binding]; other site 718254003232 Glycogen synthesis protein; Region: GlgS; cl11663 718254003233 hypothetical protein; Provisional; Region: PRK09897 718254003234 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 718254003235 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 718254003236 active site clefts [active] 718254003237 zinc binding site [ion binding]; other site 718254003238 dimer interface [polypeptide binding]; other site 718254003239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 718254003240 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 718254003241 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 718254003242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254003243 substrate binding pocket [chemical binding]; other site 718254003244 membrane-bound complex binding site; other site 718254003245 hinge residues; other site 718254003246 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718254003247 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718254003248 Walker A/P-loop; other site 718254003249 ATP binding site [chemical binding]; other site 718254003250 Q-loop/lid; other site 718254003251 ABC transporter signature motif; other site 718254003252 Walker B; other site 718254003253 D-loop; other site 718254003254 H-loop/switch region; other site 718254003255 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718254003256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254003257 dimer interface [polypeptide binding]; other site 718254003258 conserved gate region; other site 718254003259 putative PBP binding loops; other site 718254003260 ABC-ATPase subunit interface; other site 718254003261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254003262 dimer interface [polypeptide binding]; other site 718254003263 conserved gate region; other site 718254003264 putative PBP binding loops; other site 718254003265 ABC-ATPase subunit interface; other site 718254003266 hypothetical protein; Provisional; Region: PRK10292 718254003267 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 718254003268 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 718254003269 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 718254003270 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 718254003271 Walker A/P-loop; other site 718254003272 ATP binding site [chemical binding]; other site 718254003273 Q-loop/lid; other site 718254003274 ABC transporter signature motif; other site 718254003275 Walker B; other site 718254003276 D-loop; other site 718254003277 H-loop/switch region; other site 718254003278 NIL domain; Region: NIL; pfam09383 718254003279 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 718254003280 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 718254003281 dimer interface [polypeptide binding]; other site 718254003282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254003283 catalytic residue [active] 718254003284 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 718254003285 FOG: CBS domain [General function prediction only]; Region: COG0517 718254003286 pyruvate kinase; Provisional; Region: PRK09206 718254003287 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 718254003288 domain interfaces; other site 718254003289 active site 718254003290 murein lipoprotein; Provisional; Region: PRK15396 718254003291 L,D-transpeptidase; Provisional; Region: PRK10260 718254003292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718254003293 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718254003294 cysteine desufuration protein SufE; Provisional; Region: PRK09296 718254003295 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 718254003296 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 718254003297 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718254003298 catalytic residue [active] 718254003299 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 718254003300 FeS assembly protein SufD; Region: sufD; TIGR01981 718254003301 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 718254003302 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 718254003303 Walker A/P-loop; other site 718254003304 ATP binding site [chemical binding]; other site 718254003305 Q-loop/lid; other site 718254003306 ABC transporter signature motif; other site 718254003307 Walker B; other site 718254003308 D-loop; other site 718254003309 H-loop/switch region; other site 718254003310 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 718254003311 putative ABC transporter; Region: ycf24; CHL00085 718254003312 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 718254003313 transcriptional regulator MirA; Provisional; Region: PRK15043 718254003314 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 718254003315 DNA binding residues [nucleotide binding] 718254003316 Sensors of blue-light using FAD; Region: BLUF; pfam04940 718254003317 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254003318 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; Region: PRE1; COG0638 718254003319 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 718254003320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718254003321 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254003322 DNA binding residues [nucleotide binding] 718254003323 dimerization interface [polypeptide binding]; other site 718254003324 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254003325 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254003326 PapC N-terminal domain; Region: PapC_N; pfam13954 718254003327 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254003328 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718254003329 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254003330 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254003331 Fimbrial protein; Region: Fimbrial; cl01416 718254003332 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 718254003333 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 718254003334 ligand binding site [chemical binding]; other site 718254003335 flexible hinge region; other site 718254003336 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 718254003337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 718254003338 ligand binding site [chemical binding]; other site 718254003339 flexible hinge region; other site 718254003340 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 718254003341 CoenzymeA binding site [chemical binding]; other site 718254003342 subunit interaction site [polypeptide binding]; other site 718254003343 PHB binding site; other site 718254003344 putative inner membrane protein; Provisional; Region: PRK10983 718254003345 Domain of unknown function DUF20; Region: UPF0118; pfam01594 718254003346 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 718254003347 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718254003348 Hemin uptake protein hemP; Region: hemP; cl10043 718254003349 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 718254003350 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254003351 N-terminal plug; other site 718254003352 ligand-binding site [chemical binding]; other site 718254003353 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 718254003354 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 718254003355 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 718254003356 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 718254003357 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 718254003358 putative hemin binding site; other site 718254003359 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718254003360 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254003361 ABC-ATPase subunit interface; other site 718254003362 dimer interface [polypeptide binding]; other site 718254003363 putative PBP binding regions; other site 718254003364 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 718254003365 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718254003366 Walker A/P-loop; other site 718254003367 ATP binding site [chemical binding]; other site 718254003368 Q-loop/lid; other site 718254003369 ABC transporter signature motif; other site 718254003370 Walker B; other site 718254003371 D-loop; other site 718254003372 H-loop/switch region; other site 718254003373 Uncharacterized conserved protein [Function unknown]; Region: COG0397 718254003374 hypothetical protein; Validated; Region: PRK00029 718254003375 NlpC/P60 family; Region: NLPC_P60; pfam00877 718254003376 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 718254003377 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718254003378 Walker A/P-loop; other site 718254003379 ATP binding site [chemical binding]; other site 718254003380 Q-loop/lid; other site 718254003381 ABC transporter signature motif; other site 718254003382 Walker B; other site 718254003383 D-loop; other site 718254003384 H-loop/switch region; other site 718254003385 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 718254003386 catalytic residues [active] 718254003387 dimer interface [polypeptide binding]; other site 718254003388 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254003389 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718254003390 ABC-ATPase subunit interface; other site 718254003391 putative PBP binding regions; other site 718254003392 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718254003393 IHF dimer interface [polypeptide binding]; other site 718254003394 IHF - DNA interface [nucleotide binding]; other site 718254003395 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 718254003396 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 718254003397 putative tRNA-binding site [nucleotide binding]; other site 718254003398 B3/4 domain; Region: B3_4; pfam03483 718254003399 tRNA synthetase B5 domain; Region: B5; smart00874 718254003400 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 718254003401 dimer interface [polypeptide binding]; other site 718254003402 motif 1; other site 718254003403 motif 3; other site 718254003404 motif 2; other site 718254003405 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 718254003406 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 718254003407 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 718254003408 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 718254003409 dimer interface [polypeptide binding]; other site 718254003410 motif 1; other site 718254003411 active site 718254003412 motif 2; other site 718254003413 motif 3; other site 718254003414 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 718254003415 23S rRNA binding site [nucleotide binding]; other site 718254003416 L21 binding site [polypeptide binding]; other site 718254003417 L13 binding site [polypeptide binding]; other site 718254003418 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 718254003419 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 718254003420 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 718254003421 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 718254003422 active site 718254003423 dimer interface [polypeptide binding]; other site 718254003424 motif 1; other site 718254003425 motif 2; other site 718254003426 motif 3; other site 718254003427 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 718254003428 anticodon binding site; other site 718254003429 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 718254003430 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 718254003431 6-phosphofructokinase 2; Provisional; Region: PRK10294 718254003432 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 718254003433 putative substrate binding site [chemical binding]; other site 718254003434 putative ATP binding site [chemical binding]; other site 718254003435 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 718254003436 Phosphotransferase enzyme family; Region: APH; pfam01636 718254003437 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 718254003438 active site 718254003439 ATP binding site [chemical binding]; other site 718254003440 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 718254003441 active site 718254003442 ATP binding site [chemical binding]; other site 718254003443 YniB-like protein; Region: YniB; pfam14002 718254003444 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 718254003445 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718254003446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254003447 motif II; other site 718254003448 inner membrane protein; Provisional; Region: PRK11648 718254003449 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 718254003450 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718254003451 cell division modulator; Provisional; Region: PRK10113 718254003452 hydroperoxidase II; Provisional; Region: katE; PRK11249 718254003453 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 718254003454 tetramer interface [polypeptide binding]; other site 718254003455 heme binding pocket [chemical binding]; other site 718254003456 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 718254003457 domain interactions; other site 718254003458 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 718254003459 putative active site [active] 718254003460 YdjC motif; other site 718254003461 Mg binding site [ion binding]; other site 718254003462 putative homodimer interface [polypeptide binding]; other site 718254003463 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 718254003464 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 718254003465 NAD binding site [chemical binding]; other site 718254003466 sugar binding site [chemical binding]; other site 718254003467 divalent metal binding site [ion binding]; other site 718254003468 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718254003469 dimer interface [polypeptide binding]; other site 718254003470 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 718254003471 Cupin domain; Region: Cupin_2; pfam07883 718254003472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254003473 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 718254003474 methionine cluster; other site 718254003475 active site 718254003476 phosphorylation site [posttranslational modification] 718254003477 metal binding site [ion binding]; metal-binding site 718254003478 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 718254003479 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 718254003480 active site 718254003481 P-loop; other site 718254003482 phosphorylation site [posttranslational modification] 718254003483 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 718254003484 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 718254003485 GIY-YIG motif/motif A; other site 718254003486 active site 718254003487 catalytic site [active] 718254003488 putative DNA binding site [nucleotide binding]; other site 718254003489 metal binding site [ion binding]; metal-binding site 718254003490 hypothetical protein; Provisional; Region: PRK11396 718254003491 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 718254003492 dimer interface [polypeptide binding]; other site 718254003493 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 718254003494 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 718254003495 putative active site [active] 718254003496 Zn binding site [ion binding]; other site 718254003497 arginine succinyltransferase; Provisional; Region: PRK10456 718254003498 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 718254003499 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 718254003500 putative catalytic site [active] 718254003501 putative phosphate binding site [ion binding]; other site 718254003502 active site 718254003503 metal binding site A [ion binding]; metal-binding site 718254003504 DNA binding site [nucleotide binding] 718254003505 putative AP binding site [nucleotide binding]; other site 718254003506 putative metal binding site B [ion binding]; other site 718254003507 Uncharacterized conserved protein [Function unknown]; Region: COG0398 718254003508 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718254003509 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 718254003510 hypothetical protein; Provisional; Region: PRK11622 718254003511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254003512 ABC-ATPase subunit interface; other site 718254003513 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 718254003514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254003515 Walker A/P-loop; other site 718254003516 ATP binding site [chemical binding]; other site 718254003517 Q-loop/lid; other site 718254003518 ABC transporter signature motif; other site 718254003519 Walker B; other site 718254003520 D-loop; other site 718254003521 H-loop/switch region; other site 718254003522 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 718254003523 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 718254003524 active site residue [active] 718254003525 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 718254003526 active site residue [active] 718254003527 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 718254003528 Uncharacterized conserved protein [Function unknown]; Region: COG2128 718254003529 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 718254003530 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 718254003531 active site 718254003532 8-oxo-dGMP binding site [chemical binding]; other site 718254003533 nudix motif; other site 718254003534 metal binding site [ion binding]; metal-binding site 718254003535 glutamate dehydrogenase; Provisional; Region: PRK09414 718254003536 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 718254003537 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 718254003538 NAD(P) binding site [chemical binding]; other site 718254003539 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254003540 putative active site [active] 718254003541 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254003542 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254003543 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718254003544 trimer interface [polypeptide binding]; other site 718254003545 eyelet of channel; other site 718254003546 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 718254003547 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 718254003548 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 718254003549 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254003550 active site turn [active] 718254003551 phosphorylation site [posttranslational modification] 718254003552 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254003553 Beta-lactamase; Region: Beta-lactamase; cl17358 718254003554 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 718254003555 selenophosphate synthetase; Provisional; Region: PRK00943 718254003556 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 718254003557 dimerization interface [polypeptide binding]; other site 718254003558 putative ATP binding site [chemical binding]; other site 718254003559 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 718254003560 putative FMN binding site [chemical binding]; other site 718254003561 protease 4; Provisional; Region: PRK10949 718254003562 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 718254003563 tandem repeat interface [polypeptide binding]; other site 718254003564 oligomer interface [polypeptide binding]; other site 718254003565 active site residues [active] 718254003566 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 718254003567 tandem repeat interface [polypeptide binding]; other site 718254003568 oligomer interface [polypeptide binding]; other site 718254003569 active site residues [active] 718254003570 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 718254003571 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 718254003572 Isochorismatase family; Region: Isochorismatase; pfam00857 718254003573 catalytic triad [active] 718254003574 metal binding site [ion binding]; metal-binding site 718254003575 conserved cis-peptide bond; other site 718254003576 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 718254003577 Glyco_18 domain; Region: Glyco_18; smart00636 718254003578 active site 718254003579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 718254003580 methionine sulfoxide reductase B; Provisional; Region: PRK00222 718254003581 SelR domain; Region: SelR; pfam01641 718254003582 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 718254003583 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 718254003584 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 718254003585 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 718254003586 active site 718254003587 phosphate binding residues; other site 718254003588 catalytic residues [active] 718254003589 PrkA family serine protein kinase; Provisional; Region: PRK15455 718254003590 AAA ATPase domain; Region: AAA_16; pfam13191 718254003591 Walker A motif; other site 718254003592 ATP binding site [chemical binding]; other site 718254003593 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 718254003594 hypothetical protein; Provisional; Region: PRK05325 718254003595 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 718254003596 putative deacylase active site [active] 718254003597 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 718254003598 MFS/sugar transport protein; Region: MFS_2; pfam13347 718254003599 alpha-glucosidase; Provisional; Region: PRK10426 718254003600 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 718254003601 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 718254003602 putative active site [active] 718254003603 putative catalytic site [active] 718254003604 Predicted membrane protein [Function unknown]; Region: COG2707 718254003605 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718254003606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254003607 hypothetical protein; Validated; Region: PRK06186 718254003608 conserved cys residue [active] 718254003609 Uncharacterized conserved protein [Function unknown]; Region: COG3189 718254003610 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 718254003611 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 718254003612 Domain of unknown function (DUF333); Region: DUF333; pfam03891 718254003613 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 718254003614 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 718254003615 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254003616 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254003617 metal binding site [ion binding]; metal-binding site 718254003618 active site 718254003619 I-site; other site 718254003620 hypothetical protein; Provisional; Region: PRK10457 718254003621 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 718254003622 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 718254003623 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254003624 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 718254003625 isocitrate dehydrogenase; Validated; Region: PRK07362 718254003626 isocitrate dehydrogenase; Reviewed; Region: PRK07006 718254003627 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 718254003628 nudix motif; other site 718254003629 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 718254003630 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 718254003631 adenylosuccinate lyase; Provisional; Region: PRK09285 718254003632 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 718254003633 tetramer interface [polypeptide binding]; other site 718254003634 active site 718254003635 anti-adapter protein IraM; Provisional; Region: PRK09919 718254003636 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 718254003637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254003638 active site 718254003639 phosphorylation site [posttranslational modification] 718254003640 intermolecular recognition site; other site 718254003641 dimerization interface [polypeptide binding]; other site 718254003642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254003643 DNA binding site [nucleotide binding] 718254003644 sensor protein PhoQ; Provisional; Region: PRK10815 718254003645 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 718254003646 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 718254003647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254003648 ATP binding site [chemical binding]; other site 718254003649 Mg2+ binding site [ion binding]; other site 718254003650 G-X-G motif; other site 718254003651 Uncharacterized conserved protein [Function unknown]; Region: COG2850 718254003652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 718254003653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254003654 dimer interface [polypeptide binding]; other site 718254003655 conserved gate region; other site 718254003656 putative PBP binding loops; other site 718254003657 ABC-ATPase subunit interface; other site 718254003658 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 718254003659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254003660 dimer interface [polypeptide binding]; other site 718254003661 conserved gate region; other site 718254003662 putative PBP binding loops; other site 718254003663 ABC-ATPase subunit interface; other site 718254003664 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 718254003665 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 718254003666 NAD-dependent deacetylase; Provisional; Region: PRK00481 718254003667 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 718254003668 NAD+ binding site [chemical binding]; other site 718254003669 substrate binding site [chemical binding]; other site 718254003670 Zn binding site [ion binding]; other site 718254003671 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 718254003672 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718254003673 nucleotide binding site [chemical binding]; other site 718254003674 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 718254003675 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718254003676 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 718254003677 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718254003678 Walker A/P-loop; other site 718254003679 ATP binding site [chemical binding]; other site 718254003680 Q-loop/lid; other site 718254003681 ABC transporter signature motif; other site 718254003682 Walker B; other site 718254003683 D-loop; other site 718254003684 H-loop/switch region; other site 718254003685 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 718254003686 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718254003687 FtsX-like permease family; Region: FtsX; pfam02687 718254003688 Predicted membrane protein [Function unknown]; Region: COG4763 718254003689 Acyltransferase family; Region: Acyl_transf_3; pfam01757 718254003690 transcription-repair coupling factor; Provisional; Region: PRK10689 718254003691 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 718254003692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718254003693 ATP binding site [chemical binding]; other site 718254003694 putative Mg++ binding site [ion binding]; other site 718254003695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254003696 nucleotide binding region [chemical binding]; other site 718254003697 ATP-binding site [chemical binding]; other site 718254003698 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 718254003699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718254003700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254003701 hypothetical protein; Provisional; Region: PRK11280 718254003702 hypothetical protein; Provisional; Region: PRK04940 718254003703 beta-hexosaminidase; Provisional; Region: PRK05337 718254003704 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 718254003705 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 718254003706 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 718254003707 putative dimer interface [polypeptide binding]; other site 718254003708 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 718254003709 nucleotide binding site/active site [active] 718254003710 HIT family signature motif; other site 718254003711 catalytic residue [active] 718254003712 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 718254003713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254003714 N-terminal plug; other site 718254003715 ligand-binding site [chemical binding]; other site 718254003716 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 718254003717 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254003718 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254003719 active site turn [active] 718254003720 phosphorylation site [posttranslational modification] 718254003721 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 718254003722 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 718254003723 active site 718254003724 DNA polymerase III subunit delta'; Validated; Region: PRK07993 718254003725 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 718254003726 thymidylate kinase; Validated; Region: tmk; PRK00698 718254003727 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 718254003728 TMP-binding site; other site 718254003729 ATP-binding site [chemical binding]; other site 718254003730 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 718254003731 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 718254003732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254003733 catalytic residue [active] 718254003734 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 718254003735 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718254003736 dimer interface [polypeptide binding]; other site 718254003737 active site 718254003738 acyl carrier protein; Provisional; Region: acpP; PRK00982 718254003739 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 718254003740 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 718254003741 NAD(P) binding site [chemical binding]; other site 718254003742 homotetramer interface [polypeptide binding]; other site 718254003743 homodimer interface [polypeptide binding]; other site 718254003744 active site 718254003745 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 718254003746 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 718254003747 putative phosphate acyltransferase; Provisional; Region: PRK05331 718254003748 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 718254003749 hypothetical protein; Provisional; Region: PRK11193 718254003750 Maf-like protein; Region: Maf; pfam02545 718254003751 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 718254003752 active site 718254003753 dimer interface [polypeptide binding]; other site 718254003754 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 718254003755 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718254003756 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 718254003757 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254003758 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 718254003759 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 718254003760 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 718254003761 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 718254003762 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 718254003763 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 718254003764 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 718254003765 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 718254003766 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 718254003767 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254003768 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718254003769 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 718254003770 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254003771 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718254003772 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 718254003773 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254003774 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 718254003775 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718254003776 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 718254003777 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 718254003778 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 718254003779 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 718254003780 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254003781 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718254003782 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 718254003783 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 718254003784 SAF-like; Region: SAF_2; pfam13144 718254003785 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 718254003786 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 718254003787 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 718254003788 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 718254003789 hypothetical protein; Provisional; Region: PRK11239 718254003790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 718254003791 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 718254003792 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 718254003793 multidrug resistance protein MdtH; Provisional; Region: PRK11646 718254003794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254003795 putative substrate translocation pore; other site 718254003796 lipoprotein; Provisional; Region: PRK10598 718254003797 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 718254003798 active site 718254003799 substrate binding pocket [chemical binding]; other site 718254003800 dimer interface [polypeptide binding]; other site 718254003801 DNA damage-inducible protein I; Provisional; Region: PRK10597 718254003802 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 718254003803 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 718254003804 hydroxyglutarate oxidase; Provisional; Region: PRK11728 718254003805 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 718254003806 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 718254003807 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 718254003808 active site residue [active] 718254003809 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 718254003810 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718254003811 putative acyl-acceptor binding pocket; other site 718254003812 drug efflux system protein MdtG; Provisional; Region: PRK09874 718254003813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254003814 putative substrate translocation pore; other site 718254003815 secY/secA suppressor protein; Provisional; Region: PRK11467 718254003816 lipoprotein; Provisional; Region: PRK10175 718254003817 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 718254003818 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 718254003819 Ligand binding site; other site 718254003820 DXD motif; other site 718254003821 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 718254003822 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 718254003823 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 718254003824 Acyltransferase family; Region: Acyl_transf_3; pfam01757 718254003825 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 718254003826 putative ADP-ribose binding site [chemical binding]; other site 718254003827 putative active site [active] 718254003828 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 718254003829 major curlin subunit; Provisional; Region: csgA; PRK10051 718254003830 Curlin associated repeat; Region: Curlin_rpt; pfam07012 718254003831 Curlin associated repeat; Region: Curlin_rpt; pfam07012 718254003832 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 718254003833 Curlin associated repeat; Region: Curlin_rpt; pfam07012 718254003834 Curlin associated repeat; Region: Curlin_rpt; pfam07012 718254003835 Curlin associated repeat; Region: Curlin_rpt; pfam07012 718254003836 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 718254003837 putative hydrolase; Validated; Region: PRK09248 718254003838 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 718254003839 active site 718254003840 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 718254003841 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 718254003842 putative ligand binding site [chemical binding]; other site 718254003843 NAD binding site [chemical binding]; other site 718254003844 dimerization interface [polypeptide binding]; other site 718254003845 catalytic site [active] 718254003846 LysR family transcriptional regulator; Provisional; Region: PRK14997 718254003847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254003848 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 718254003849 putative effector binding pocket; other site 718254003850 putative dimerization interface [polypeptide binding]; other site 718254003851 Pirin-related protein [General function prediction only]; Region: COG1741 718254003852 Pirin; Region: Pirin; pfam02678 718254003853 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 718254003854 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 718254003855 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 718254003856 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 718254003857 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 718254003858 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 718254003859 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 718254003860 Imelysin; Region: Peptidase_M75; pfam09375 718254003861 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 718254003862 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 718254003863 Nucleoside recognition; Region: Gate; pfam07670 718254003864 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 718254003865 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 718254003866 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 718254003867 Predicted transcriptional regulator [Transcription]; Region: COG3905 718254003868 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 718254003869 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 718254003870 Glutamate binding site [chemical binding]; other site 718254003871 NAD binding site [chemical binding]; other site 718254003872 catalytic residues [active] 718254003873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 718254003874 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 718254003875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254003876 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 718254003877 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718254003878 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 718254003879 Isochorismatase family; Region: Isochorismatase; pfam00857 718254003880 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 718254003881 catalytic triad [active] 718254003882 conserved cis-peptide bond; other site 718254003883 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 718254003884 homotrimer interaction site [polypeptide binding]; other site 718254003885 putative active site [active] 718254003886 pyrimidine utilization protein D; Region: RutD; TIGR03611 718254003887 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 718254003888 putative FMN binding site [chemical binding]; other site 718254003889 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 718254003890 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 718254003891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 718254003892 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 718254003893 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718254003894 EamA-like transporter family; Region: EamA; pfam00892 718254003895 EamA-like transporter family; Region: EamA; pfam00892 718254003896 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 718254003897 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 718254003898 hypothetical protein; Provisional; Region: PRK10174 718254003899 Predicted transcriptional regulators [Transcription]; Region: COG1733 718254003900 Predicted transcriptional regulators [Transcription]; Region: COG1733 718254003901 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 718254003902 short chain dehydrogenase; Provisional; Region: PRK06500 718254003903 classical (c) SDRs; Region: SDR_c; cd05233 718254003904 NAD(P) binding site [chemical binding]; other site 718254003905 active site 718254003906 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718254003907 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718254003908 FOG: CBS domain [General function prediction only]; Region: COG0517 718254003909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 718254003910 Divalent cation transporter; Region: MgtE; pfam01769 718254003911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718254003912 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 718254003913 DNA binding residues [nucleotide binding] 718254003914 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718254003915 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718254003916 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 718254003917 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 718254003918 putative ligand binding residues [chemical binding]; other site 718254003919 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718254003920 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254003921 ABC-ATPase subunit interface; other site 718254003922 dimer interface [polypeptide binding]; other site 718254003923 putative PBP binding regions; other site 718254003924 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 718254003925 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718254003926 Walker A/P-loop; other site 718254003927 ATP binding site [chemical binding]; other site 718254003928 Q-loop/lid; other site 718254003929 ABC transporter signature motif; other site 718254003930 Walker B; other site 718254003931 D-loop; other site 718254003932 H-loop/switch region; other site 718254003933 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 718254003934 YccA-like proteins; Region: YccA_like; cd10433 718254003935 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 718254003936 sulfur transfer protein TusE; Provisional; Region: PRK11508 718254003937 acylphosphatase; Provisional; Region: PRK14426 718254003938 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 718254003939 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 718254003940 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 718254003941 putative RNA binding site [nucleotide binding]; other site 718254003942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254003943 S-adenosylmethionine binding site [chemical binding]; other site 718254003944 heat shock protein HspQ; Provisional; Region: PRK14129 718254003945 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 718254003946 hypothetical protein; Provisional; Region: PRK03641 718254003947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 718254003948 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 718254003949 active site 718254003950 dimer interfaces [polypeptide binding]; other site 718254003951 catalytic residues [active] 718254003952 DNA helicase IV; Provisional; Region: helD; PRK11054 718254003953 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 718254003954 Part of AAA domain; Region: AAA_19; pfam13245 718254003955 Family description; Region: UvrD_C_2; pfam13538 718254003956 Predicted membrane protein [Function unknown]; Region: COG3304 718254003957 Domain of unknown function (DUF307); Region: DUF307; pfam03733 718254003958 Domain of unknown function (DUF307); Region: DUF307; pfam03733 718254003959 TIGR01666 family membrane protein; Region: YCCS 718254003960 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 718254003961 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718254003962 TfoX N-terminal domain; Region: TfoX_N; pfam04993 718254003963 TfoX C-terminal domain; Region: TfoX_C; pfam04994 718254003964 SOS cell division inhibitor; Provisional; Region: PRK10595 718254003965 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 718254003966 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 718254003967 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 718254003968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 718254003969 Protein of unknown function (DUF330); Region: DUF330; pfam03886 718254003970 paraquat-inducible protein B; Provisional; Region: PRK10807 718254003971 mce related protein; Region: MCE; pfam02470 718254003972 mce related protein; Region: MCE; pfam02470 718254003973 mce related protein; Region: MCE; pfam02470 718254003974 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 718254003975 Paraquat-inducible protein A; Region: PqiA; pfam04403 718254003976 Paraquat-inducible protein A; Region: PqiA; pfam04403 718254003977 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 718254003978 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254003979 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 718254003980 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 718254003981 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 718254003982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254003983 S-adenosylmethionine binding site [chemical binding]; other site 718254003984 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 718254003985 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 718254003986 MOSC domain; Region: MOSC; pfam03473 718254003987 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 718254003988 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718254003989 catalytic loop [active] 718254003990 iron binding site [ion binding]; other site 718254003991 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 718254003992 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 718254003993 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 718254003994 quinone interaction residues [chemical binding]; other site 718254003995 active site 718254003996 catalytic residues [active] 718254003997 FMN binding site [chemical binding]; other site 718254003998 substrate binding site [chemical binding]; other site 718254003999 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 718254004000 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 718254004001 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 718254004002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254004003 substrate binding pocket [chemical binding]; other site 718254004004 membrane-bound complex binding site; other site 718254004005 hinge residues; other site 718254004006 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 718254004007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004008 dimer interface [polypeptide binding]; other site 718254004009 conserved gate region; other site 718254004010 putative PBP binding loops; other site 718254004011 ABC-ATPase subunit interface; other site 718254004012 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 718254004013 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 718254004014 Walker A/P-loop; other site 718254004015 ATP binding site [chemical binding]; other site 718254004016 Q-loop/lid; other site 718254004017 ABC transporter signature motif; other site 718254004018 Walker B; other site 718254004019 D-loop; other site 718254004020 H-loop/switch region; other site 718254004021 aminopeptidase N; Provisional; Region: pepN; PRK14015 718254004022 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 718254004023 active site 718254004024 Zn binding site [ion binding]; other site 718254004025 multiple promoter invertase; Provisional; Region: mpi; PRK13413 718254004026 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 718254004027 catalytic residues [active] 718254004028 catalytic nucleophile [active] 718254004029 Presynaptic Site I dimer interface [polypeptide binding]; other site 718254004030 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 718254004031 Synaptic Flat tetramer interface [polypeptide binding]; other site 718254004032 Synaptic Site I dimer interface [polypeptide binding]; other site 718254004033 DNA binding site [nucleotide binding] 718254004034 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 718254004035 DNA-binding interface [nucleotide binding]; DNA binding site 718254004036 Phage-related protein, tail component [Function unknown]; Region: COG4733 718254004037 Putative phage tail protein; Region: Phage-tail_3; pfam13550 718254004038 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 718254004039 Interdomain contacts; other site 718254004040 Cytokine receptor motif; other site 718254004041 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 718254004042 Phage-related protein, tail component [Function unknown]; Region: COG4723 718254004043 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 718254004044 MPN+ (JAMM) motif; other site 718254004045 Zinc-binding site [ion binding]; other site 718254004046 NlpC/P60 family; Region: NLPC_P60; pfam00877 718254004047 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 718254004048 Phage minor tail protein L; Region: Phage_tail_L; cl01908 718254004049 Phage minor tail protein; Region: Phage_min_tail; pfam05939 718254004050 Phage-related minor tail protein [Function unknown]; Region: COG5281 718254004051 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 718254004052 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 718254004053 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 718254004054 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 718254004055 Phage tail protein; Region: Phage_tail_3; pfam08813 718254004056 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 718254004057 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 718254004058 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 718254004059 Terminase-like family; Region: Terminase_6; pfam03237 718254004060 Terminase small subunit; Region: Terminase_2; pfam03592 718254004061 P63C domain; Region: P63C; pfam10546 718254004062 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 718254004063 tellurite resistance protein terB; Region: terB; cd07176 718254004064 putative metal binding site [ion binding]; other site 718254004065 HNH endonuclease; Region: HNH_3; pfam13392 718254004066 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 718254004067 Antitermination protein; Region: Antiterm; pfam03589 718254004068 Antitermination protein; Region: Antiterm; pfam03589 718254004069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 718254004070 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 718254004071 Toprim domain; Region: Toprim_3; pfam13362 718254004072 active site 718254004073 metal binding site [ion binding]; metal-binding site 718254004074 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 718254004075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254004076 non-specific DNA binding site [nucleotide binding]; other site 718254004077 Predicted transcriptional regulator [Transcription]; Region: COG2932 718254004078 salt bridge; other site 718254004079 sequence-specific DNA binding site [nucleotide binding]; other site 718254004080 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718254004081 Catalytic site [active] 718254004082 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 718254004083 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 718254004084 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 718254004085 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 718254004086 Int/Topo IB signature motif; other site 718254004087 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 718254004088 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 718254004089 active site 718254004090 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 718254004091 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 718254004092 putative dimer interface [polypeptide binding]; other site 718254004093 putative anticodon binding site; other site 718254004094 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 718254004095 homodimer interface [polypeptide binding]; other site 718254004096 motif 1; other site 718254004097 motif 2; other site 718254004098 active site 718254004099 motif 3; other site 718254004100 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254004101 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718254004102 trimer interface [polypeptide binding]; other site 718254004103 eyelet of channel; other site 718254004104 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718254004105 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 718254004106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 718254004107 Peptidase M15; Region: Peptidase_M15_3; cl01194 718254004108 murein L,D-transpeptidase; Provisional; Region: PRK10594 718254004109 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 718254004110 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718254004111 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718254004112 cell division protein MukB; Provisional; Region: mukB; PRK04863 718254004113 P-loop containing region of AAA domain; Region: AAA_29; cl17516 718254004114 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 718254004115 condesin subunit E; Provisional; Region: PRK05256 718254004116 condesin subunit F; Provisional; Region: PRK05260 718254004117 Methyltransferase domain; Region: Methyltransf_23; pfam13489 718254004118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254004119 S-adenosylmethionine binding site [chemical binding]; other site 718254004120 Uncharacterized conserved protein [Function unknown]; Region: COG1434 718254004121 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 718254004122 putative active site [active] 718254004123 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 718254004124 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 718254004125 Ligand binding site; other site 718254004126 oligomer interface; other site 718254004127 Trm112p-like protein; Region: Trm112p; cl01066 718254004128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 718254004129 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 718254004130 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 718254004131 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 718254004132 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 718254004133 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718254004134 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 718254004135 Walker A/P-loop; other site 718254004136 ATP binding site [chemical binding]; other site 718254004137 Q-loop/lid; other site 718254004138 ABC transporter signature motif; other site 718254004139 Walker B; other site 718254004140 D-loop; other site 718254004141 H-loop/switch region; other site 718254004142 ComEC family competence protein; Provisional; Region: PRK11539 718254004143 Competence protein; Region: Competence; pfam03772 718254004144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 718254004145 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718254004146 IHF dimer interface [polypeptide binding]; other site 718254004147 IHF - DNA interface [nucleotide binding]; other site 718254004148 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 718254004149 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 718254004150 RNA binding site [nucleotide binding]; other site 718254004151 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 718254004152 RNA binding site [nucleotide binding]; other site 718254004153 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 718254004154 RNA binding site [nucleotide binding]; other site 718254004155 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 718254004156 RNA binding site [nucleotide binding]; other site 718254004157 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 718254004158 RNA binding site [nucleotide binding]; other site 718254004159 cytidylate kinase; Provisional; Region: cmk; PRK00023 718254004160 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 718254004161 CMP-binding site; other site 718254004162 The sites determining sugar specificity; other site 718254004163 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 718254004164 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 718254004165 putative active site [active] 718254004166 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 718254004167 homodimer interface [polypeptide binding]; other site 718254004168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254004169 substrate-cofactor binding pocket; other site 718254004170 catalytic residue [active] 718254004171 Predicted membrane protein [Function unknown]; Region: COG2323 718254004172 Predicted membrane protein [Function unknown]; Region: COG2323 718254004173 uncharacterized domain; Region: TIGR00702 718254004174 YcaO-like family; Region: YcaO; pfam02624 718254004175 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 718254004176 Pyruvate formate lyase 1; Region: PFL1; cd01678 718254004177 coenzyme A binding site [chemical binding]; other site 718254004178 active site 718254004179 catalytic residues [active] 718254004180 glycine loop; other site 718254004181 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 718254004182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254004183 FeS/SAM binding site; other site 718254004184 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 718254004185 putative MFS family transporter protein; Provisional; Region: PRK03633 718254004186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254004187 putative substrate translocation pore; other site 718254004188 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 718254004189 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 718254004190 putative [Fe4-S4] binding site [ion binding]; other site 718254004191 putative molybdopterin cofactor binding site [chemical binding]; other site 718254004192 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 718254004193 putative molybdopterin cofactor binding site; other site 718254004194 seryl-tRNA synthetase; Provisional; Region: PRK05431 718254004195 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 718254004196 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 718254004197 dimer interface [polypeptide binding]; other site 718254004198 active site 718254004199 motif 1; other site 718254004200 motif 2; other site 718254004201 motif 3; other site 718254004202 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 718254004203 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 718254004204 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 718254004205 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 718254004206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254004207 putative DNA binding site [nucleotide binding]; other site 718254004208 putative Zn2+ binding site [ion binding]; other site 718254004209 AsnC family; Region: AsnC_trans_reg; pfam01037 718254004210 thioredoxin reductase; Provisional; Region: PRK10262 718254004211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718254004212 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254004213 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 718254004214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718254004215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254004216 Walker A/P-loop; other site 718254004217 ATP binding site [chemical binding]; other site 718254004218 Q-loop/lid; other site 718254004219 ABC transporter signature motif; other site 718254004220 Walker B; other site 718254004221 D-loop; other site 718254004222 H-loop/switch region; other site 718254004223 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 718254004224 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 718254004225 rRNA binding site [nucleotide binding]; other site 718254004226 predicted 30S ribosome binding site; other site 718254004227 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 718254004228 Clp amino terminal domain; Region: Clp_N; pfam02861 718254004229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254004230 Walker A motif; other site 718254004231 ATP binding site [chemical binding]; other site 718254004232 Walker B motif; other site 718254004233 arginine finger; other site 718254004234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254004235 Walker A motif; other site 718254004236 ATP binding site [chemical binding]; other site 718254004237 Walker B motif; other site 718254004238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718254004239 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 718254004240 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718254004241 DNA-binding site [nucleotide binding]; DNA binding site 718254004242 RNA-binding motif; other site 718254004243 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 718254004244 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718254004245 Walker A/P-loop; other site 718254004246 ATP binding site [chemical binding]; other site 718254004247 Q-loop/lid; other site 718254004248 ABC transporter signature motif; other site 718254004249 Walker B; other site 718254004250 D-loop; other site 718254004251 H-loop/switch region; other site 718254004252 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718254004253 FtsX-like permease family; Region: FtsX; pfam02687 718254004254 macrolide transporter subunit MacA; Provisional; Region: PRK11578 718254004255 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254004256 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254004257 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 718254004258 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 718254004259 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 718254004260 putative active site [active] 718254004261 putative metal-binding site [ion binding]; other site 718254004262 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 718254004263 amphipathic channel; other site 718254004264 Asn-Pro-Ala signature motifs; other site 718254004265 Predicted membrane protein [Function unknown]; Region: COG2431 718254004266 hybrid cluster protein; Provisional; Region: PRK05290 718254004267 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718254004268 ACS interaction site; other site 718254004269 CODH interaction site; other site 718254004270 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 718254004271 hybrid metal cluster; other site 718254004272 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 718254004273 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 718254004274 FAD binding pocket [chemical binding]; other site 718254004275 FAD binding motif [chemical binding]; other site 718254004276 phosphate binding motif [ion binding]; other site 718254004277 beta-alpha-beta structure motif; other site 718254004278 NAD binding pocket [chemical binding]; other site 718254004279 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718254004280 catalytic loop [active] 718254004281 iron binding site [ion binding]; other site 718254004282 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 718254004283 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 718254004284 tetramer interface [polypeptide binding]; other site 718254004285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254004286 catalytic residue [active] 718254004287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254004288 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 718254004289 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 718254004290 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 718254004291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254004292 NAD(P) binding site [chemical binding]; other site 718254004293 active site 718254004294 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 718254004295 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 718254004296 putative sugar binding site [chemical binding]; other site 718254004297 catalytic residues [active] 718254004298 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 718254004299 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 718254004300 aromatic chitin/cellulose binding site residues [chemical binding]; other site 718254004301 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718254004302 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718254004303 Chitinase A, N-terminal domain; Region: ChitinaseA_N; pfam08329 718254004304 Glyco_18 domain; Region: Glyco_18; smart00636 718254004305 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 718254004306 active site 718254004307 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 718254004308 aromatic chitin/cellulose binding site residues [chemical binding]; other site 718254004309 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 718254004310 aromatic chitin/cellulose binding site residues [chemical binding]; other site 718254004311 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 718254004312 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 718254004313 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 718254004314 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 718254004315 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 718254004316 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 718254004317 GspL periplasmic domain; Region: GspL_C; cl14909 718254004318 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 718254004319 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 718254004320 type II secretion system protein I; Region: gspI; TIGR01707 718254004321 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 718254004322 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 718254004323 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 718254004324 Type II transport protein GspH; Region: GspH; pfam12019 718254004325 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 718254004326 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 718254004327 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 718254004328 type II secretion system protein D; Region: type_II_gspD; TIGR02517 718254004329 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718254004330 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718254004331 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718254004332 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 718254004333 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 718254004334 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 718254004335 ligand binding site [chemical binding]; other site 718254004336 flexible hinge region; other site 718254004337 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 718254004338 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 718254004339 amidase catalytic site [active] 718254004340 Zn binding residues [ion binding]; other site 718254004341 substrate binding site [chemical binding]; other site 718254004342 hypothetical protein; Provisional; Region: PRK02877 718254004343 putative lipoprotein; Provisional; Region: PRK10533 718254004344 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 718254004345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254004346 substrate binding pocket [chemical binding]; other site 718254004347 membrane-bound complex binding site; other site 718254004348 hinge residues; other site 718254004349 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718254004350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004351 dimer interface [polypeptide binding]; other site 718254004352 conserved gate region; other site 718254004353 putative PBP binding loops; other site 718254004354 ABC-ATPase subunit interface; other site 718254004355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004356 dimer interface [polypeptide binding]; other site 718254004357 conserved gate region; other site 718254004358 putative PBP binding loops; other site 718254004359 ABC-ATPase subunit interface; other site 718254004360 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 718254004361 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254004362 substrate binding pocket [chemical binding]; other site 718254004363 membrane-bound complex binding site; other site 718254004364 hinge residues; other site 718254004365 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 718254004366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254004367 dimer interface [polypeptide binding]; other site 718254004368 phosphorylation site [posttranslational modification] 718254004369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254004370 ATP binding site [chemical binding]; other site 718254004371 Mg2+ binding site [ion binding]; other site 718254004372 G-X-G motif; other site 718254004373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718254004374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254004375 active site 718254004376 phosphorylation site [posttranslational modification] 718254004377 intermolecular recognition site; other site 718254004378 dimerization interface [polypeptide binding]; other site 718254004379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254004380 DNA binding site [nucleotide binding] 718254004381 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 718254004382 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 718254004383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004384 dimer interface [polypeptide binding]; other site 718254004385 conserved gate region; other site 718254004386 putative PBP binding loops; other site 718254004387 ABC-ATPase subunit interface; other site 718254004388 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 718254004389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004390 dimer interface [polypeptide binding]; other site 718254004391 conserved gate region; other site 718254004392 putative PBP binding loops; other site 718254004393 ABC-ATPase subunit interface; other site 718254004394 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 718254004395 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 718254004396 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 718254004397 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 718254004398 RimK-like ATP-grasp domain; Region: RimK; pfam08443 718254004399 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 718254004400 dimer interface [polypeptide binding]; other site 718254004401 FMN binding site [chemical binding]; other site 718254004402 NADPH bind site [chemical binding]; other site 718254004403 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 718254004404 GSH binding site [chemical binding]; other site 718254004405 catalytic residues [active] 718254004406 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 718254004407 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254004408 dimerization interface [polypeptide binding]; other site 718254004409 putative DNA binding site [nucleotide binding]; other site 718254004410 putative Zn2+ binding site [ion binding]; other site 718254004411 arsenical pump membrane protein; Provisional; Region: PRK15445 718254004412 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 718254004413 transmembrane helices; other site 718254004414 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 718254004415 ArsC family; Region: ArsC; pfam03960 718254004416 catalytic residues [active] 718254004417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 718254004418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254004419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254004420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254004421 putative substrate translocation pore; other site 718254004422 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 718254004423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 718254004424 active site 718254004425 motif I; other site 718254004426 motif II; other site 718254004427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254004428 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 718254004429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254004430 putative substrate translocation pore; other site 718254004431 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 718254004432 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 718254004433 active site 718254004434 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 718254004435 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 718254004436 putative C-terminal domain interface [polypeptide binding]; other site 718254004437 putative GSH binding site (G-site) [chemical binding]; other site 718254004438 putative dimer interface [polypeptide binding]; other site 718254004439 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 718254004440 putative N-terminal domain interface [polypeptide binding]; other site 718254004441 putative dimer interface [polypeptide binding]; other site 718254004442 putative substrate binding pocket (H-site) [chemical binding]; other site 718254004443 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 718254004444 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 718254004445 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 718254004446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004447 dimer interface [polypeptide binding]; other site 718254004448 conserved gate region; other site 718254004449 putative PBP binding loops; other site 718254004450 ABC-ATPase subunit interface; other site 718254004451 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 718254004452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004453 dimer interface [polypeptide binding]; other site 718254004454 conserved gate region; other site 718254004455 putative PBP binding loops; other site 718254004456 ABC-ATPase subunit interface; other site 718254004457 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 718254004458 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 718254004459 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 718254004460 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254004461 Walker A/P-loop; other site 718254004462 ATP binding site [chemical binding]; other site 718254004463 Q-loop/lid; other site 718254004464 ABC transporter signature motif; other site 718254004465 Walker B; other site 718254004466 D-loop; other site 718254004467 H-loop/switch region; other site 718254004468 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 718254004469 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 718254004470 catalytic nucleophile [active] 718254004471 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 718254004472 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 718254004473 dimer interface [polypeptide binding]; other site 718254004474 putative functional site; other site 718254004475 putative MPT binding site; other site 718254004476 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 718254004477 ATP binding site [chemical binding]; other site 718254004478 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 718254004479 substrate interface [chemical binding]; other site 718254004480 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 718254004481 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254004482 FeS/SAM binding site; other site 718254004483 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 718254004484 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 718254004485 dimer interface [polypeptide binding]; other site 718254004486 active site 718254004487 glycine loop; other site 718254004488 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 718254004489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254004490 active site 718254004491 motif I; other site 718254004492 motif II; other site 718254004493 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718254004494 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 718254004495 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254004496 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254004497 DNA binding site [nucleotide binding] 718254004498 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 718254004499 ligand binding site [chemical binding]; other site 718254004500 dimerization interface [polypeptide binding]; other site 718254004501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254004502 D-galactonate transporter; Region: 2A0114; TIGR00893 718254004503 putative substrate translocation pore; other site 718254004504 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 718254004505 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 718254004506 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 718254004507 putative active site [active] 718254004508 putative catalytic site [active] 718254004509 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 718254004510 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254004511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254004512 ABC transporter; Region: ABC_tran_2; pfam12848 718254004513 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254004514 L,D-transpeptidase; Provisional; Region: PRK10260 718254004515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 718254004516 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718254004517 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 718254004518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254004519 DNA-binding site [nucleotide binding]; DNA binding site 718254004520 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 718254004521 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 718254004522 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 718254004523 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 718254004524 beta-galactosidase; Region: BGL; TIGR03356 718254004525 Outer membrane efflux protein; Region: OEP; pfam02321 718254004526 Outer membrane efflux protein; Region: OEP; pfam02321 718254004527 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 718254004528 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 718254004529 homodimer interface [polypeptide binding]; other site 718254004530 active site 718254004531 TDP-binding site; other site 718254004532 acceptor substrate-binding pocket; other site 718254004533 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 718254004534 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 718254004535 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 718254004536 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 718254004537 outer membrane receptor FepA; Provisional; Region: PRK13528 718254004538 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254004539 N-terminal plug; other site 718254004540 ligand-binding site [chemical binding]; other site 718254004541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254004542 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254004543 active site 718254004544 catalytic tetrad [active] 718254004545 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 718254004546 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 718254004547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254004548 putative substrate translocation pore; other site 718254004549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254004550 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 718254004551 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254004552 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254004553 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718254004554 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 718254004555 transmembrane helices; other site 718254004556 manganese transport regulator MntR; Provisional; Region: PRK11050 718254004557 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 718254004558 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 718254004559 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 718254004560 Sulfatase; Region: Sulfatase; pfam00884 718254004561 outer membrane protein X; Provisional; Region: ompX; PRK09408 718254004562 threonine and homoserine efflux system; Provisional; Region: PRK10532 718254004563 EamA-like transporter family; Region: EamA; pfam00892 718254004564 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 718254004565 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 718254004566 dimerization interface [polypeptide binding]; other site 718254004567 DPS ferroxidase diiron center [ion binding]; other site 718254004568 ion pore; other site 718254004569 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 718254004570 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254004571 substrate binding pocket [chemical binding]; other site 718254004572 membrane-bound complex binding site; other site 718254004573 hinge residues; other site 718254004574 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 718254004575 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 718254004576 S-adenosylmethionine binding site [chemical binding]; other site 718254004577 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718254004578 hypothetical protein; Provisional; Region: PRK11019 718254004579 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 718254004580 Fimbrial protein; Region: Fimbrial; cl01416 718254004581 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718254004582 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254004583 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254004584 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254004585 PapC N-terminal domain; Region: PapC_N; pfam13954 718254004586 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254004587 PapC C-terminal domain; Region: PapC_C; pfam13953 718254004588 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254004589 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254004590 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 718254004591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 718254004592 DEAD_2; Region: DEAD_2; pfam06733 718254004593 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 718254004594 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 718254004595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254004596 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 718254004597 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 718254004598 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254004599 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254004600 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 718254004601 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 718254004602 Walker A/P-loop; other site 718254004603 ATP binding site [chemical binding]; other site 718254004604 Q-loop/lid; other site 718254004605 ABC transporter signature motif; other site 718254004606 Walker B; other site 718254004607 D-loop; other site 718254004608 H-loop/switch region; other site 718254004609 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 718254004610 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 718254004611 Walker A/P-loop; other site 718254004612 ATP binding site [chemical binding]; other site 718254004613 Q-loop/lid; other site 718254004614 ABC transporter signature motif; other site 718254004615 Walker B; other site 718254004616 D-loop; other site 718254004617 H-loop/switch region; other site 718254004618 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 718254004619 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 718254004620 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 718254004621 cardiolipin synthase 2; Provisional; Region: PRK11263 718254004622 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 718254004623 putative active site [active] 718254004624 catalytic site [active] 718254004625 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 718254004626 putative active site [active] 718254004627 catalytic site [active] 718254004628 Predicted integral membrane protein [Function unknown]; Region: COG0392 718254004629 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 718254004630 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 718254004631 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 718254004632 MoaE homodimer interface [polypeptide binding]; other site 718254004633 MoaD interaction [polypeptide binding]; other site 718254004634 active site residues [active] 718254004635 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 718254004636 MoaE interaction surface [polypeptide binding]; other site 718254004637 MoeB interaction surface [polypeptide binding]; other site 718254004638 thiocarboxylated glycine; other site 718254004639 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 718254004640 trimer interface [polypeptide binding]; other site 718254004641 dimer interface [polypeptide binding]; other site 718254004642 putative active site [active] 718254004643 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 718254004644 MPT binding site; other site 718254004645 trimer interface [polypeptide binding]; other site 718254004646 excinuclease ABC subunit B; Provisional; Region: PRK05298 718254004647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718254004648 ATP binding site [chemical binding]; other site 718254004649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254004650 nucleotide binding region [chemical binding]; other site 718254004651 ATP-binding site [chemical binding]; other site 718254004652 Ultra-violet resistance protein B; Region: UvrB; pfam12344 718254004653 UvrB/uvrC motif; Region: UVR; pfam02151 718254004654 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 718254004655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254004656 Walker A/P-loop; other site 718254004657 ATP binding site [chemical binding]; other site 718254004658 Q-loop/lid; other site 718254004659 ABC transporter signature motif; other site 718254004660 Walker B; other site 718254004661 D-loop; other site 718254004662 H-loop/switch region; other site 718254004663 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 718254004664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254004665 S-adenosylmethionine binding site [chemical binding]; other site 718254004666 biotin synthase; Provisional; Region: PRK15108 718254004667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254004668 FeS/SAM binding site; other site 718254004669 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 718254004670 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 718254004671 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718254004672 inhibitor-cofactor binding pocket; inhibition site 718254004673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254004674 catalytic residue [active] 718254004675 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 718254004676 substrate binding site [chemical binding]; other site 718254004677 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 718254004678 active sites [active] 718254004679 tetramer interface [polypeptide binding]; other site 718254004680 urocanate hydratase; Provisional; Region: PRK05414 718254004681 histidine utilization repressor; Provisional; Region: PRK14999 718254004682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254004683 DNA-binding site [nucleotide binding]; DNA binding site 718254004684 UTRA domain; Region: UTRA; pfam07702 718254004685 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 718254004686 putative active site [active] 718254004687 putative metal binding site [ion binding]; other site 718254004688 imidazolonepropionase; Validated; Region: PRK09356 718254004689 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 718254004690 active site 718254004691 acyl-CoA thioesterase; Provisional; Region: PRK10531 718254004692 putative pectinesterase; Region: PLN02432; cl01911 718254004693 6-phosphogluconolactonase; Provisional; Region: PRK11028 718254004694 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 718254004695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004696 dimer interface [polypeptide binding]; other site 718254004697 conserved gate region; other site 718254004698 putative PBP binding loops; other site 718254004699 ABC-ATPase subunit interface; other site 718254004700 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 718254004701 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254004702 substrate binding pocket [chemical binding]; other site 718254004703 membrane-bound complex binding site; other site 718254004704 hinge residues; other site 718254004705 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 718254004706 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 718254004707 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 718254004708 molybdenum-pterin binding domain; Region: Mop; TIGR00638 718254004709 TOBE domain; Region: TOBE; pfam03459 718254004710 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 718254004711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254004712 Walker A/P-loop; other site 718254004713 ATP binding site [chemical binding]; other site 718254004714 Q-loop/lid; other site 718254004715 ABC transporter signature motif; other site 718254004716 Walker B; other site 718254004717 D-loop; other site 718254004718 H-loop/switch region; other site 718254004719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254004720 Walker A/P-loop; other site 718254004721 ATP binding site [chemical binding]; other site 718254004722 Q-loop/lid; other site 718254004723 ABC transporter signature motif; other site 718254004724 Walker B; other site 718254004725 D-loop; other site 718254004726 H-loop/switch region; other site 718254004727 galactokinase; Provisional; Region: PRK05101 718254004728 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 718254004729 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718254004730 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718254004731 catalytic core [active] 718254004732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718254004733 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 718254004734 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718254004735 zinc transporter ZitB; Provisional; Region: PRK03557 718254004736 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 718254004737 quinolinate synthetase; Provisional; Region: PRK09375 718254004738 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 718254004739 Tetratricopeptide repeat; Region: TPR_6; pfam13174 718254004740 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 718254004741 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718254004742 ligand binding site [chemical binding]; other site 718254004743 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 718254004744 colicin uptake protein TolR; Provisional; Region: PRK11024 718254004745 colicin uptake protein TolQ; Provisional; Region: PRK10801 718254004746 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 718254004747 active site 718254004748 hypothetical protein; Provisional; Region: PRK10588 718254004749 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 718254004750 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 718254004751 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 718254004752 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 718254004753 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 718254004754 alpha-mannosidase; Provisional; Region: PRK09819 718254004755 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 718254004756 active site 718254004757 metal binding site [ion binding]; metal-binding site 718254004758 catalytic site [active] 718254004759 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 718254004760 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 718254004761 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254004762 active site 718254004763 phosphorylation site [posttranslational modification] 718254004764 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 718254004765 active site 718254004766 P-loop; other site 718254004767 phosphorylation site [posttranslational modification] 718254004768 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 718254004769 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 718254004770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254004771 DNA-binding site [nucleotide binding]; DNA binding site 718254004772 UTRA domain; Region: UTRA; pfam07702 718254004773 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 718254004774 CoA binding domain; Region: CoA_binding; smart00881 718254004775 CoA-ligase; Region: Ligase_CoA; pfam00549 718254004776 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 718254004777 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718254004778 E3 interaction surface; other site 718254004779 lipoyl attachment site [posttranslational modification]; other site 718254004780 e3 binding domain; Region: E3_binding; pfam02817 718254004781 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 718254004782 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 718254004783 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 718254004784 TPP-binding site [chemical binding]; other site 718254004785 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 718254004786 dimer interface [polypeptide binding]; other site 718254004787 PYR/PP interface [polypeptide binding]; other site 718254004788 TPP binding site [chemical binding]; other site 718254004789 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 718254004790 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 718254004791 C2 domain; Region: C2; cl14603 718254004792 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 718254004793 L-aspartate oxidase; Provisional; Region: PRK06175 718254004794 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 718254004795 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 718254004796 SdhC subunit interface [polypeptide binding]; other site 718254004797 proximal heme binding site [chemical binding]; other site 718254004798 cardiolipin binding site; other site 718254004799 Iron-sulfur protein interface; other site 718254004800 proximal quinone binding site [chemical binding]; other site 718254004801 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 718254004802 Iron-sulfur protein interface; other site 718254004803 proximal quinone binding site [chemical binding]; other site 718254004804 SdhD (CybS) interface [polypeptide binding]; other site 718254004805 proximal heme binding site [chemical binding]; other site 718254004806 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 718254004807 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 718254004808 dimer interface [polypeptide binding]; other site 718254004809 active site 718254004810 citrylCoA binding site [chemical binding]; other site 718254004811 NADH binding [chemical binding]; other site 718254004812 cationic pore residues; other site 718254004813 oxalacetate/citrate binding site [chemical binding]; other site 718254004814 coenzyme A binding site [chemical binding]; other site 718254004815 catalytic triad [active] 718254004816 endonuclease VIII; Provisional; Region: PRK10445 718254004817 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 718254004818 DNA binding site [nucleotide binding] 718254004819 catalytic residue [active] 718254004820 putative catalytic residues [active] 718254004821 H2TH interface [polypeptide binding]; other site 718254004822 intercalation triad [nucleotide binding]; other site 718254004823 substrate specificity determining residue; other site 718254004824 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 718254004825 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 718254004826 LamB/YcsF family protein; Provisional; Region: PRK05406 718254004827 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 718254004828 DNA photolyase; Region: DNA_photolyase; pfam00875 718254004829 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 718254004830 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 718254004831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718254004832 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 718254004833 sensor protein KdpD; Provisional; Region: PRK10490 718254004834 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 718254004835 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 718254004836 Ligand Binding Site [chemical binding]; other site 718254004837 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 718254004838 GAF domain; Region: GAF_3; pfam13492 718254004839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254004840 dimer interface [polypeptide binding]; other site 718254004841 phosphorylation site [posttranslational modification] 718254004842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254004843 ATP binding site [chemical binding]; other site 718254004844 Mg2+ binding site [ion binding]; other site 718254004845 G-X-G motif; other site 718254004846 ornithine decarboxylase; Provisional; Region: PRK13578 718254004847 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718254004848 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 718254004849 homodimer interface [polypeptide binding]; other site 718254004850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254004851 catalytic residue [active] 718254004852 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718254004853 putrescine transporter; Provisional; Region: potE; PRK10655 718254004854 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 718254004855 phosphoglucomutase; Validated; Region: PRK07564 718254004856 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 718254004857 active site 718254004858 substrate binding site [chemical binding]; other site 718254004859 metal binding site [ion binding]; metal-binding site 718254004860 replication initiation regulator SeqA; Provisional; Region: PRK11187 718254004861 acyl-CoA esterase; Provisional; Region: PRK10673 718254004862 PGAP1-like protein; Region: PGAP1; pfam07819 718254004863 LexA regulated protein; Provisional; Region: PRK11675 718254004864 flavodoxin FldA; Validated; Region: PRK09267 718254004865 ferric uptake regulator; Provisional; Region: fur; PRK09462 718254004866 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 718254004867 metal binding site 2 [ion binding]; metal-binding site 718254004868 putative DNA binding helix; other site 718254004869 metal binding site 1 [ion binding]; metal-binding site 718254004870 dimer interface [polypeptide binding]; other site 718254004871 structural Zn2+ binding site [ion binding]; other site 718254004872 outer membrane porin, OprD family; Region: OprD; pfam03573 718254004873 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 718254004874 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718254004875 active site 718254004876 HIGH motif; other site 718254004877 nucleotide binding site [chemical binding]; other site 718254004878 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 718254004879 KMSKS motif; other site 718254004880 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 718254004881 MarR family; Region: MarR; pfam01047 718254004882 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 718254004883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718254004884 nucleotide binding site [chemical binding]; other site 718254004885 UMP phosphatase; Provisional; Region: PRK10444 718254004886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254004887 active site 718254004888 motif I; other site 718254004889 motif II; other site 718254004890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254004891 asparagine synthetase B; Provisional; Region: asnB; PRK09431 718254004892 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 718254004893 active site 718254004894 dimer interface [polypeptide binding]; other site 718254004895 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 718254004896 Ligand Binding Site [chemical binding]; other site 718254004897 Molecular Tunnel; other site 718254004898 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 718254004899 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 718254004900 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 718254004901 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 718254004902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254004903 FeS/SAM binding site; other site 718254004904 TRAM domain; Region: TRAM; pfam01938 718254004905 metal-binding heat shock protein; Provisional; Region: PRK00016 718254004906 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 718254004907 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718254004908 Transporter associated domain; Region: CorC_HlyC; smart01091 718254004909 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 718254004910 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 718254004911 putative active site [active] 718254004912 catalytic triad [active] 718254004913 putative dimer interface [polypeptide binding]; other site 718254004914 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 718254004915 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254004916 substrate binding pocket [chemical binding]; other site 718254004917 membrane-bound complex binding site; other site 718254004918 hinge residues; other site 718254004919 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718254004920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004921 dimer interface [polypeptide binding]; other site 718254004922 conserved gate region; other site 718254004923 putative PBP binding loops; other site 718254004924 ABC-ATPase subunit interface; other site 718254004925 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718254004926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254004927 dimer interface [polypeptide binding]; other site 718254004928 conserved gate region; other site 718254004929 putative PBP binding loops; other site 718254004930 ABC-ATPase subunit interface; other site 718254004931 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718254004932 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718254004933 Walker A/P-loop; other site 718254004934 ATP binding site [chemical binding]; other site 718254004935 Q-loop/lid; other site 718254004936 ABC transporter signature motif; other site 718254004937 Walker B; other site 718254004938 D-loop; other site 718254004939 H-loop/switch region; other site 718254004940 hypothetical protein; Provisional; Region: PRK11032 718254004941 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 718254004942 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 718254004943 HIGH motif; other site 718254004944 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718254004945 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718254004946 active site 718254004947 KMSKS motif; other site 718254004948 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 718254004949 tRNA binding surface [nucleotide binding]; other site 718254004950 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 718254004951 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 718254004952 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 718254004953 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 718254004954 active site 718254004955 (T/H)XGH motif; other site 718254004956 penicillin-binding protein 2; Provisional; Region: PRK10795 718254004957 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718254004958 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718254004959 cell wall shape-determining protein; Provisional; Region: PRK10794 718254004960 rare lipoprotein A; Provisional; Region: PRK10672 718254004961 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 718254004962 Sporulation related domain; Region: SPOR; pfam05036 718254004963 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 718254004964 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 718254004965 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 718254004966 hypothetical protein; Provisional; Region: PRK04998 718254004967 lipoate-protein ligase B; Provisional; Region: PRK14342 718254004968 lipoyl synthase; Provisional; Region: PRK05481 718254004969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254004970 FeS/SAM binding site; other site 718254004971 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 718254004972 chromosome condensation membrane protein; Provisional; Region: PRK14196 718254004973 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718254004974 DNA-binding site [nucleotide binding]; DNA binding site 718254004975 RNA-binding motif; other site 718254004976 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 718254004977 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 718254004978 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 718254004979 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 718254004980 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 718254004981 B1 nucleotide binding pocket [chemical binding]; other site 718254004982 B2 nucleotide binding pocket [chemical binding]; other site 718254004983 CAS motifs; other site 718254004984 active site 718254004985 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 718254004986 active site 718254004987 P-loop; other site 718254004988 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 718254004989 aminopeptidase; Provisional; Region: PRK09795 718254004990 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 718254004991 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 718254004992 active site 718254004993 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718254004994 dimerization domain swap beta strand [polypeptide binding]; other site 718254004995 regulatory protein interface [polypeptide binding]; other site 718254004996 active site 718254004997 regulatory phosphorylation site [posttranslational modification]; other site 718254004998 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 718254004999 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 718254005000 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 718254005001 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 718254005002 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254005003 active site 718254005004 phosphorylation site [posttranslational modification] 718254005005 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 718254005006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254005007 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 718254005008 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 718254005009 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 718254005010 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 718254005011 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 718254005012 NAD binding site [chemical binding]; other site 718254005013 catalytic Zn binding site [ion binding]; other site 718254005014 structural Zn binding site [ion binding]; other site 718254005015 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 718254005016 catalytic residue [active] 718254005017 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 718254005018 catalytic residues [active] 718254005019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254005020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254005021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254005022 dimerization interface [polypeptide binding]; other site 718254005023 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 718254005024 Active Sites [active] 718254005025 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 718254005026 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 718254005027 ParB-like nuclease domain; Region: ParBc; pfam02195 718254005028 methionine aminotransferase; Validated; Region: PRK09082 718254005029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254005030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254005031 homodimer interface [polypeptide binding]; other site 718254005032 catalytic residue [active] 718254005033 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 718254005034 intersubunit interface [polypeptide binding]; other site 718254005035 active site 718254005036 Zn2+ binding site [ion binding]; other site 718254005037 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 718254005038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254005039 motif II; other site 718254005040 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 718254005041 Cupin domain; Region: Cupin_2; cl17218 718254005042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254005043 non-specific DNA binding site [nucleotide binding]; other site 718254005044 salt bridge; other site 718254005045 sequence-specific DNA binding site [nucleotide binding]; other site 718254005046 Uncharacterized conserved protein [Function unknown]; Region: COG5276 718254005047 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 718254005048 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 718254005049 putative ligand binding site [chemical binding]; other site 718254005050 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 718254005051 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254005052 Walker A/P-loop; other site 718254005053 ATP binding site [chemical binding]; other site 718254005054 Q-loop/lid; other site 718254005055 ABC transporter signature motif; other site 718254005056 Walker B; other site 718254005057 D-loop; other site 718254005058 H-loop/switch region; other site 718254005059 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254005060 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 718254005061 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 718254005062 putative active site [active] 718254005063 metal binding site [ion binding]; metal-binding site 718254005064 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 718254005065 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 718254005066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254005067 salt bridge; other site 718254005068 non-specific DNA binding site [nucleotide binding]; other site 718254005069 sequence-specific DNA binding site [nucleotide binding]; other site 718254005070 Uncharacterized small protein [Function unknown]; Region: COG2879 718254005071 carbon starvation protein A; Provisional; Region: PRK15015 718254005072 Carbon starvation protein CstA; Region: CstA; pfam02554 718254005073 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 718254005074 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 718254005075 CoenzymeA binding site [chemical binding]; other site 718254005076 subunit interaction site [polypeptide binding]; other site 718254005077 PHB binding site; other site 718254005078 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 718254005079 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 718254005080 putative NAD(P) binding site [chemical binding]; other site 718254005081 active site 718254005082 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 718254005083 hydrophobic substrate binding pocket; other site 718254005084 Isochorismatase family; Region: Isochorismatase; pfam00857 718254005085 active site 718254005086 conserved cis-peptide bond; other site 718254005087 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 718254005088 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 718254005089 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 718254005090 acyl-activating enzyme (AAE) consensus motif; other site 718254005091 active site 718254005092 AMP binding site [chemical binding]; other site 718254005093 substrate binding site [chemical binding]; other site 718254005094 isochorismate synthase EntC; Provisional; Region: PRK15016 718254005095 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 718254005096 enterobactin exporter EntS; Provisional; Region: PRK10489 718254005097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005098 putative substrate translocation pore; other site 718254005099 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718254005100 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254005101 ABC-ATPase subunit interface; other site 718254005102 dimer interface [polypeptide binding]; other site 718254005103 putative PBP binding regions; other site 718254005104 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 718254005105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254005106 ABC-ATPase subunit interface; other site 718254005107 dimer interface [polypeptide binding]; other site 718254005108 putative PBP binding regions; other site 718254005109 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 718254005110 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 718254005111 acyl-activating enzyme (AAE) consensus motif; other site 718254005112 AMP binding site [chemical binding]; other site 718254005113 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 718254005114 MbtH-like protein; Region: MbtH; cl01279 718254005115 outer membrane receptor FepA; Provisional; Region: PRK13524 718254005116 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254005117 N-terminal plug; other site 718254005118 ligand-binding site [chemical binding]; other site 718254005119 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718254005120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254005121 ABC-ATPase subunit interface; other site 718254005122 dimer interface [polypeptide binding]; other site 718254005123 putative PBP binding regions; other site 718254005124 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718254005125 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254005126 ABC-ATPase subunit interface; other site 718254005127 dimer interface [polypeptide binding]; other site 718254005128 putative PBP binding regions; other site 718254005129 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 718254005130 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 718254005131 transcriptional regulator BetI; Validated; Region: PRK00767 718254005132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254005133 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 718254005134 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 718254005135 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 718254005136 tetrameric interface [polypeptide binding]; other site 718254005137 NAD binding site [chemical binding]; other site 718254005138 catalytic residues [active] 718254005139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718254005140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254005141 dimer interface [polypeptide binding]; other site 718254005142 conserved gate region; other site 718254005143 putative PBP binding loops; other site 718254005144 ABC-ATPase subunit interface; other site 718254005145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 718254005146 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 718254005147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254005148 dimer interface [polypeptide binding]; other site 718254005149 conserved gate region; other site 718254005150 ABC-ATPase subunit interface; other site 718254005151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 718254005152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254005153 Walker A/P-loop; other site 718254005154 ATP binding site [chemical binding]; other site 718254005155 Q-loop/lid; other site 718254005156 ABC transporter signature motif; other site 718254005157 Walker B; other site 718254005158 D-loop; other site 718254005159 H-loop/switch region; other site 718254005160 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718254005161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254005162 Walker A/P-loop; other site 718254005163 ATP binding site [chemical binding]; other site 718254005164 Q-loop/lid; other site 718254005165 ABC transporter signature motif; other site 718254005166 Walker B; other site 718254005167 D-loop; other site 718254005168 H-loop/switch region; other site 718254005169 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718254005170 DNA-binding site [nucleotide binding]; DNA binding site 718254005171 RNA-binding motif; other site 718254005172 acetoin reductase; Validated; Region: PRK08643 718254005173 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 718254005174 NAD binding site [chemical binding]; other site 718254005175 homotetramer interface [polypeptide binding]; other site 718254005176 homodimer interface [polypeptide binding]; other site 718254005177 active site 718254005178 substrate binding site [chemical binding]; other site 718254005179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254005180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254005181 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 718254005182 putative dimerization interface [polypeptide binding]; other site 718254005183 putative substrate binding pocket [chemical binding]; other site 718254005184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 718254005185 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 718254005186 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 718254005187 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 718254005188 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 718254005189 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 718254005190 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 718254005191 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 718254005192 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 718254005193 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 718254005194 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718254005195 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254005196 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 718254005197 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 718254005198 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718254005199 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 718254005200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254005201 motif II; other site 718254005202 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 718254005203 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 718254005204 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 718254005205 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254005206 N-terminal plug; other site 718254005207 ligand-binding site [chemical binding]; other site 718254005208 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 718254005209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254005210 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 718254005211 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 718254005212 hypothetical protein; Provisional; Region: PRK10250 718254005213 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 718254005214 dimer interface [polypeptide binding]; other site 718254005215 FMN binding site [chemical binding]; other site 718254005216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254005217 non-specific DNA binding site [nucleotide binding]; other site 718254005218 salt bridge; other site 718254005219 sequence-specific DNA binding site [nucleotide binding]; other site 718254005220 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 718254005221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254005222 sequence-specific DNA binding site [nucleotide binding]; other site 718254005223 salt bridge; other site 718254005224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254005226 putative substrate translocation pore; other site 718254005227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005228 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718254005229 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718254005230 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254005231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254005232 DNA binding site [nucleotide binding] 718254005233 domain linker motif; other site 718254005234 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 718254005235 dimerization interface [polypeptide binding]; other site 718254005236 ligand binding site [chemical binding]; other site 718254005237 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718254005238 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718254005239 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 718254005240 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 718254005241 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 718254005242 Metal-binding active site; metal-binding site 718254005243 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 718254005244 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 718254005245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005246 putative substrate translocation pore; other site 718254005247 hypothetical protein; Provisional; Region: PRK09929 718254005248 transcriptional regulator FimZ; Provisional; Region: PRK09935 718254005249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254005250 active site 718254005251 phosphorylation site [posttranslational modification] 718254005252 intermolecular recognition site; other site 718254005253 dimerization interface [polypeptide binding]; other site 718254005254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254005255 DNA binding residues [nucleotide binding] 718254005256 dimerization interface [polypeptide binding]; other site 718254005257 Fimbrial protein; Region: Fimbrial; cl01416 718254005258 outer membrane usher protein FimD; Provisional; Region: PRK15198 718254005259 PapC N-terminal domain; Region: PapC_N; pfam13954 718254005260 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254005261 PapC C-terminal domain; Region: PapC_C; pfam13953 718254005262 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 718254005263 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254005264 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254005265 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 718254005266 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 718254005267 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 718254005268 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 718254005269 homodimer interface [polypeptide binding]; other site 718254005270 NADP binding site [chemical binding]; other site 718254005271 substrate binding site [chemical binding]; other site 718254005272 ribosome-associated protein; Provisional; Region: PRK11507 718254005273 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 718254005274 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254005275 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254005276 active site turn [active] 718254005277 phosphorylation site [posttranslational modification] 718254005278 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 718254005279 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 718254005280 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718254005281 active site 718254005282 HIGH motif; other site 718254005283 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718254005284 KMSKS motif; other site 718254005285 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 718254005286 tRNA binding surface [nucleotide binding]; other site 718254005287 anticodon binding site; other site 718254005288 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 718254005289 substrate binding site [chemical binding]; other site 718254005290 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 718254005291 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 718254005292 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 718254005293 active site residue [active] 718254005294 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254005295 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 718254005296 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254005297 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 718254005298 FtsX-like permease family; Region: FtsX; pfam02687 718254005299 FtsX-like permease family; Region: FtsX; pfam02687 718254005300 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718254005301 ABC transporter signature motif; other site 718254005302 Walker B; other site 718254005303 D-loop; other site 718254005304 H-loop/switch region; other site 718254005305 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 718254005306 active site 718254005307 catalytic triad [active] 718254005308 oxyanion hole [active] 718254005309 switch loop; other site 718254005310 oxidoreductase; Provisional; Region: PRK08017 718254005311 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 718254005312 NADP binding site [chemical binding]; other site 718254005313 active site 718254005314 steroid binding site; other site 718254005315 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 718254005316 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 718254005317 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 718254005318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254005319 Walker A/P-loop; other site 718254005320 ATP binding site [chemical binding]; other site 718254005321 Q-loop/lid; other site 718254005322 ABC transporter signature motif; other site 718254005323 Walker B; other site 718254005324 D-loop; other site 718254005325 H-loop/switch region; other site 718254005326 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 718254005327 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 718254005328 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 718254005329 copper exporting ATPase; Provisional; Region: copA; PRK10671 718254005330 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718254005331 metal-binding site [ion binding] 718254005332 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718254005333 metal-binding site [ion binding] 718254005334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718254005335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254005336 motif II; other site 718254005337 TraB family; Region: TraB; cl12050 718254005338 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 718254005339 putative deacylase active site [active] 718254005340 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 718254005341 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 718254005342 active site 718254005343 metal binding site [ion binding]; metal-binding site 718254005344 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 718254005345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254005347 putative substrate translocation pore; other site 718254005348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005349 putative cation:proton antiport protein; Provisional; Region: PRK10669 718254005350 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 718254005351 TrkA-N domain; Region: TrkA_N; pfam02254 718254005352 ferrochelatase; Reviewed; Region: hemH; PRK00035 718254005353 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 718254005354 C-terminal domain interface [polypeptide binding]; other site 718254005355 active site 718254005356 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 718254005357 active site 718254005358 N-terminal domain interface [polypeptide binding]; other site 718254005359 adenylate kinase; Reviewed; Region: adk; PRK00279 718254005360 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 718254005361 AMP-binding site [chemical binding]; other site 718254005362 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 718254005363 heat shock protein 90; Provisional; Region: PRK05218 718254005364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254005365 ATP binding site [chemical binding]; other site 718254005366 Mg2+ binding site [ion binding]; other site 718254005367 G-X-G motif; other site 718254005368 recombination protein RecR; Reviewed; Region: recR; PRK00076 718254005369 RecR protein; Region: RecR; pfam02132 718254005370 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 718254005371 putative active site [active] 718254005372 putative metal-binding site [ion binding]; other site 718254005373 tetramer interface [polypeptide binding]; other site 718254005374 hypothetical protein; Validated; Region: PRK00153 718254005375 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718254005376 active site 718254005377 hypothetical protein; Provisional; Region: PRK10527 718254005378 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 718254005379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254005380 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 718254005381 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 718254005382 Protein export membrane protein; Region: SecD_SecF; cl14618 718254005383 Protein export membrane protein; Region: SecD_SecF; cl14618 718254005384 Hha toxicity attenuator; Provisional; Region: PRK10667 718254005385 gene expression modulator; Provisional; Region: PRK10945 718254005386 maltose O-acetyltransferase; Provisional; Region: PRK10092 718254005387 Maltose acetyltransferase; Region: Mac; pfam12464 718254005388 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 718254005389 trimer interface [polypeptide binding]; other site 718254005390 active site 718254005391 substrate binding site [chemical binding]; other site 718254005392 CoA binding site [chemical binding]; other site 718254005393 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 718254005394 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 718254005395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254005396 DNA-binding site [nucleotide binding]; DNA binding site 718254005397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254005398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254005399 homodimer interface [polypeptide binding]; other site 718254005400 catalytic residue [active] 718254005401 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 718254005402 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 718254005403 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 718254005404 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 718254005405 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254005406 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 718254005407 putative metal binding site [ion binding]; other site 718254005408 putative homodimer interface [polypeptide binding]; other site 718254005409 putative homotetramer interface [polypeptide binding]; other site 718254005410 putative homodimer-homodimer interface [polypeptide binding]; other site 718254005411 putative allosteric switch controlling residues; other site 718254005412 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 718254005413 lac repressor; Reviewed; Region: lacI; PRK09526 718254005414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254005415 DNA binding site [nucleotide binding] 718254005416 domain linker motif; other site 718254005417 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 718254005418 ligand binding site [chemical binding]; other site 718254005419 dimerization interface (open form) [polypeptide binding]; other site 718254005420 dimerization interface (closed form) [polypeptide binding]; other site 718254005421 Predicted membrane protein [Function unknown]; Region: COG2364 718254005422 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 718254005423 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 718254005424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254005425 DNA-binding site [nucleotide binding]; DNA binding site 718254005426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254005427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254005428 homodimer interface [polypeptide binding]; other site 718254005429 catalytic residue [active] 718254005430 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 718254005431 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 718254005432 DNA binding site [nucleotide binding] 718254005433 active site 718254005434 acyl-CoA thioesterase II; Provisional; Region: PRK10526 718254005435 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 718254005436 active site 718254005437 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 718254005438 catalytic triad [active] 718254005439 dimer interface [polypeptide binding]; other site 718254005440 ammonium transporter; Provisional; Region: PRK10666 718254005441 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 718254005442 Nitrogen regulatory protein P-II; Region: P-II; smart00938 718254005443 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 718254005444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718254005445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254005446 Walker A/P-loop; other site 718254005447 ATP binding site [chemical binding]; other site 718254005448 Q-loop/lid; other site 718254005449 ABC transporter signature motif; other site 718254005450 Walker B; other site 718254005451 D-loop; other site 718254005452 H-loop/switch region; other site 718254005453 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 718254005454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254005455 putative DNA binding site [nucleotide binding]; other site 718254005456 putative Zn2+ binding site [ion binding]; other site 718254005457 AsnC family; Region: AsnC_trans_reg; pfam01037 718254005458 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 718254005459 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 718254005460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718254005461 catalytic residue [active] 718254005462 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 718254005463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254005464 active site 718254005465 motif I; other site 718254005466 motif II; other site 718254005467 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 718254005468 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 718254005469 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 718254005470 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 718254005471 Ligand Binding Site [chemical binding]; other site 718254005472 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 718254005473 active site 718254005474 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 718254005475 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 718254005476 periplasmic folding chaperone; Provisional; Region: PRK10788 718254005477 SurA N-terminal domain; Region: SurA_N_3; cl07813 718254005478 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 718254005479 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 718254005480 Found in ATP-dependent protease La (LON); Region: LON; smart00464 718254005481 Found in ATP-dependent protease La (LON); Region: LON; smart00464 718254005482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254005483 Walker A motif; other site 718254005484 ATP binding site [chemical binding]; other site 718254005485 Walker B motif; other site 718254005486 arginine finger; other site 718254005487 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 718254005488 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 718254005489 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 718254005490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254005491 Walker A motif; other site 718254005492 ATP binding site [chemical binding]; other site 718254005493 Walker B motif; other site 718254005494 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718254005495 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 718254005496 trigger factor; Provisional; Region: tig; PRK01490 718254005497 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718254005498 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 718254005499 transcriptional regulator BolA; Provisional; Region: PRK11628 718254005500 hypothetical protein; Provisional; Region: PRK11627 718254005501 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 718254005502 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 718254005503 muropeptide transporter; Reviewed; Region: ampG; PRK11902 718254005504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005505 putative substrate translocation pore; other site 718254005506 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 718254005507 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 718254005508 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 718254005509 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 718254005510 Subunit I/III interface [polypeptide binding]; other site 718254005511 Subunit III/IV interface [polypeptide binding]; other site 718254005512 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 718254005513 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 718254005514 UbiA prenyltransferase family; Region: UbiA; pfam01040 718254005515 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 718254005516 L-fucose isomerase; Provisional; Region: fucI; PRK10991 718254005517 hexamer (dimer of trimers) interface [polypeptide binding]; other site 718254005518 trimer interface [polypeptide binding]; other site 718254005519 substrate binding site [chemical binding]; other site 718254005520 Mn binding site [ion binding]; other site 718254005521 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254005522 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254005523 TM-ABC transporter signature motif; other site 718254005524 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 718254005525 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 718254005526 putative ligand binding site [chemical binding]; other site 718254005527 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 718254005528 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 718254005529 N- and C-terminal domain interface [polypeptide binding]; other site 718254005530 active site 718254005531 MgATP binding site [chemical binding]; other site 718254005532 catalytic site [active] 718254005533 metal binding site [ion binding]; metal-binding site 718254005534 carbohydrate binding site [chemical binding]; other site 718254005535 putative homodimer interface [polypeptide binding]; other site 718254005536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254005537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254005538 DNA binding site [nucleotide binding] 718254005539 domain linker motif; other site 718254005540 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 718254005541 dimerization interface [polypeptide binding]; other site 718254005542 ligand binding site [chemical binding]; other site 718254005543 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 718254005544 intersubunit interface [polypeptide binding]; other site 718254005545 active site 718254005546 Zn2+ binding site [ion binding]; other site 718254005547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005548 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254005549 putative substrate translocation pore; other site 718254005550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 718254005551 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 718254005552 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 718254005553 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 718254005554 conserved cys residue [active] 718254005555 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 718254005556 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 718254005557 NAD binding site [chemical binding]; other site 718254005558 sugar binding site [chemical binding]; other site 718254005559 divalent metal binding site [ion binding]; other site 718254005560 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718254005561 dimer interface [polypeptide binding]; other site 718254005562 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 718254005563 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 718254005564 active site 718254005565 trimer interface [polypeptide binding]; other site 718254005566 allosteric site; other site 718254005567 active site lid [active] 718254005568 hexamer (dimer of trimers) interface [polypeptide binding]; other site 718254005569 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 718254005570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254005571 DNA-binding site [nucleotide binding]; DNA binding site 718254005572 UTRA domain; Region: UTRA; pfam07702 718254005573 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 718254005574 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 718254005575 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 718254005576 Ligand Binding Site [chemical binding]; other site 718254005577 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718254005578 active site residue [active] 718254005579 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 718254005580 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 718254005581 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 718254005582 substrate binding pocket [chemical binding]; other site 718254005583 chain length determination region; other site 718254005584 substrate-Mg2+ binding site; other site 718254005585 catalytic residues [active] 718254005586 aspartate-rich region 1; other site 718254005587 active site lid residues [active] 718254005588 aspartate-rich region 2; other site 718254005589 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 718254005590 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 718254005591 TPP-binding site; other site 718254005592 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718254005593 PYR/PP interface [polypeptide binding]; other site 718254005594 dimer interface [polypeptide binding]; other site 718254005595 TPP binding site [chemical binding]; other site 718254005596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718254005597 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254005598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254005599 active site 718254005600 catalytic tetrad [active] 718254005601 thiamine monophosphate kinase; Provisional; Region: PRK05731 718254005602 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 718254005603 ATP binding site [chemical binding]; other site 718254005604 dimerization interface [polypeptide binding]; other site 718254005605 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 718254005606 homopentamer interface [polypeptide binding]; other site 718254005607 active site 718254005608 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 718254005609 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 718254005610 catalytic motif [active] 718254005611 Zn binding site [ion binding]; other site 718254005612 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 718254005613 hypothetical protein; Provisional; Region: PRK11530 718254005614 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 718254005615 Predicted transcriptional regulator [Transcription]; Region: COG2378 718254005616 HTH domain; Region: HTH_11; pfam08279 718254005617 WYL domain; Region: WYL; pfam13280 718254005618 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 718254005619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718254005620 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 718254005621 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 718254005622 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 718254005623 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 718254005624 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 718254005625 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 718254005626 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 718254005627 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 718254005628 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 718254005629 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 718254005630 peroxidase; Provisional; Region: PRK15000 718254005631 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 718254005632 dimer interface [polypeptide binding]; other site 718254005633 decamer (pentamer of dimers) interface [polypeptide binding]; other site 718254005634 catalytic triad [active] 718254005635 peroxidatic and resolving cysteines [active] 718254005636 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 718254005637 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 718254005638 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 718254005639 maltodextrin glucosidase; Provisional; Region: PRK10785 718254005640 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 718254005641 homodimer interface [polypeptide binding]; other site 718254005642 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 718254005643 active site 718254005644 homodimer interface [polypeptide binding]; other site 718254005645 catalytic site [active] 718254005646 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 718254005647 transcriptional regulator PhoB; Provisional; Region: PRK10161 718254005648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254005649 active site 718254005650 phosphorylation site [posttranslational modification] 718254005651 intermolecular recognition site; other site 718254005652 dimerization interface [polypeptide binding]; other site 718254005653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254005654 DNA binding site [nucleotide binding] 718254005655 exonuclease subunit SbcD; Provisional; Region: PRK10966 718254005656 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 718254005657 active site 718254005658 metal binding site [ion binding]; metal-binding site 718254005659 DNA binding site [nucleotide binding] 718254005660 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 718254005661 exonuclease subunit SbcC; Provisional; Region: PRK10246 718254005662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254005663 Walker A/P-loop; other site 718254005664 ATP binding site [chemical binding]; other site 718254005665 Q-loop/lid; other site 718254005666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254005667 ABC transporter signature motif; other site 718254005668 Walker B; other site 718254005669 D-loop; other site 718254005670 H-loop/switch region; other site 718254005671 hypothetical protein; Provisional; Region: PRK10579 718254005672 hypothetical protein; Provisional; Region: PRK10481 718254005673 hypothetical protein; Provisional; Region: PRK10380 718254005674 hypothetical protein; Validated; Region: PRK00124 718254005675 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 718254005676 pyrroline-5-carboxylate reductase; Region: PLN02688 718254005677 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 718254005678 MASE2 domain; Region: MASE2; pfam05230 718254005679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254005680 metal binding site [ion binding]; metal-binding site 718254005681 active site 718254005682 I-site; other site 718254005683 hypothetical protein; Provisional; Region: PRK11505 718254005684 psiF repeat; Region: PsiF_repeat; pfam07769 718254005685 psiF repeat; Region: PsiF_repeat; pfam07769 718254005686 anti-RssB factor; Provisional; Region: PRK10244 718254005687 drug efflux system protein MdtG; Provisional; Region: PRK09874 718254005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005689 putative substrate translocation pore; other site 718254005690 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 718254005691 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 718254005692 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 718254005693 microcin B17 transporter; Reviewed; Region: PRK11098 718254005694 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 718254005695 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 718254005696 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 718254005697 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718254005698 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 718254005699 dimer interface [polypeptide binding]; other site 718254005700 active site 718254005701 Schiff base residues; other site 718254005702 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 718254005703 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718254005704 putative acyl-acceptor binding pocket; other site 718254005705 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 718254005706 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 718254005707 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 718254005708 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 718254005709 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 718254005710 Walker A/P-loop; other site 718254005711 ATP binding site [chemical binding]; other site 718254005712 Q-loop/lid; other site 718254005713 ABC transporter signature motif; other site 718254005714 Walker B; other site 718254005715 D-loop; other site 718254005716 H-loop/switch region; other site 718254005717 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 718254005718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254005719 substrate binding pocket [chemical binding]; other site 718254005720 membrane-bound complex binding site; other site 718254005721 hinge residues; other site 718254005722 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 718254005723 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 718254005724 S-methylmethionine transporter; Provisional; Region: PRK11387 718254005725 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 718254005726 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254005727 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254005728 metal binding site [ion binding]; metal-binding site 718254005729 active site 718254005730 I-site; other site 718254005731 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254005732 hypothetical protein; Provisional; Region: PRK13687 718254005733 Methyltransferase domain; Region: Methyltransf_31; pfam13847 718254005734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254005735 S-adenosylmethionine binding site [chemical binding]; other site 718254005736 Divergent AAA domain; Region: AAA_4; pfam04326 718254005737 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718254005738 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 718254005739 catalytic residues [active] 718254005740 Lysis protein S; Region: Lysis_S; pfam04971 718254005741 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 718254005742 virion protein; Provisional; Region: PHA03414 718254005743 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718254005744 hypothetical protein; Region: PHA00661 718254005745 hypothetical protein; Region: PHA00662 718254005746 hypothetical protein; Region: PHA00670 718254005747 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 718254005748 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 718254005749 polymerase nucleotide-binding site; other site 718254005750 DNA-binding residues [nucleotide binding]; DNA binding site 718254005751 nucleotide binding site [chemical binding]; other site 718254005752 primase nucleotide-binding site [nucleotide binding]; other site 718254005753 Virulence-associated protein E; Region: VirE; pfam05272 718254005754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254005755 non-specific DNA binding site [nucleotide binding]; other site 718254005756 salt bridge; other site 718254005757 sequence-specific DNA binding site [nucleotide binding]; other site 718254005758 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 718254005759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254005760 sequence-specific DNA binding site [nucleotide binding]; other site 718254005761 salt bridge; other site 718254005762 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718254005763 Catalytic site [active] 718254005764 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 718254005765 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 718254005766 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 718254005767 DNA binding site [nucleotide binding] 718254005768 active site 718254005769 catalytic site [active] 718254005770 VRR-NUC domain; Region: VRR_NUC; pfam08774 718254005771 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 718254005772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254005773 nucleotide binding region [chemical binding]; other site 718254005774 ATP-binding site [chemical binding]; other site 718254005775 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 718254005776 integrase; Provisional; Region: PRK09692 718254005777 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718254005778 active site 718254005779 Int/Topo IB signature motif; other site 718254005780 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 718254005781 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 718254005782 putative catalytic cysteine [active] 718254005783 gamma-glutamyl kinase; Provisional; Region: PRK05429 718254005784 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 718254005785 nucleotide binding site [chemical binding]; other site 718254005786 homotetrameric interface [polypeptide binding]; other site 718254005787 putative phosphate binding site [ion binding]; other site 718254005788 putative allosteric binding site; other site 718254005789 PUA domain; Region: PUA; pfam01472 718254005790 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254005791 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718254005792 trimer interface [polypeptide binding]; other site 718254005793 eyelet of channel; other site 718254005794 Transcriptional regulator Crl; Region: Crl; cl11653 718254005795 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 718254005796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718254005797 active site 718254005798 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 718254005799 active site 718254005800 DNA polymerase IV; Validated; Region: PRK02406 718254005801 DNA binding site [nucleotide binding] 718254005802 Protein of unknown function (DUF539); Region: DUF539; cl01129 718254005803 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 718254005804 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 718254005805 FAD binding pocket [chemical binding]; other site 718254005806 FAD binding motif [chemical binding]; other site 718254005807 phosphate binding motif [ion binding]; other site 718254005808 beta-alpha-beta structure motif; other site 718254005809 NAD binding pocket [chemical binding]; other site 718254005810 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 718254005811 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 718254005812 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 718254005813 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 718254005814 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718254005815 E3 interaction surface; other site 718254005816 lipoyl attachment site [posttranslational modification]; other site 718254005817 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 718254005818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 718254005819 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718254005820 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 718254005821 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 718254005822 putative active site [active] 718254005823 putative dimer interface [polypeptide binding]; other site 718254005824 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 718254005825 dimer interface [polypeptide binding]; other site 718254005826 active site 718254005827 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 718254005828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 718254005829 active site 718254005830 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 718254005831 C-N hydrolase family amidase; Provisional; Region: PRK10438 718254005832 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 718254005833 putative active site [active] 718254005834 catalytic triad [active] 718254005835 dimer interface [polypeptide binding]; other site 718254005836 multimer interface [polypeptide binding]; other site 718254005837 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 718254005838 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 718254005839 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 718254005840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254005841 dimer interface [polypeptide binding]; other site 718254005842 conserved gate region; other site 718254005843 putative PBP binding loops; other site 718254005844 ABC-ATPase subunit interface; other site 718254005845 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718254005846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254005847 dimer interface [polypeptide binding]; other site 718254005848 conserved gate region; other site 718254005849 putative PBP binding loops; other site 718254005850 ABC-ATPase subunit interface; other site 718254005851 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718254005852 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 718254005853 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 718254005854 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254005855 Walker A/P-loop; other site 718254005856 ATP binding site [chemical binding]; other site 718254005857 Q-loop/lid; other site 718254005858 ABC transporter signature motif; other site 718254005859 Walker B; other site 718254005860 D-loop; other site 718254005861 H-loop/switch region; other site 718254005862 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 718254005863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 718254005864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254005865 Walker A/P-loop; other site 718254005866 ATP binding site [chemical binding]; other site 718254005867 Q-loop/lid; other site 718254005868 ABC transporter signature motif; other site 718254005869 Walker B; other site 718254005870 D-loop; other site 718254005871 H-loop/switch region; other site 718254005872 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 718254005873 Transcriptional regulators [Transcription]; Region: FadR; COG2186 718254005874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254005875 DNA-binding site [nucleotide binding]; DNA binding site 718254005876 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718254005877 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 718254005878 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 718254005879 active site 718254005880 catalytic site [active] 718254005881 substrate binding site [chemical binding]; other site 718254005882 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 718254005883 RNA/DNA hybrid binding site [nucleotide binding]; other site 718254005884 active site 718254005885 Methyltransferase domain; Region: Methyltransf_11; pfam08241 718254005886 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 718254005887 Methyltransferase domain; Region: Methyltransf_31; pfam13847 718254005888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254005889 S-adenosylmethionine binding site [chemical binding]; other site 718254005890 hypothetical protein; Provisional; Region: PRK05421 718254005891 putative catalytic site [active] 718254005892 putative metal binding site [ion binding]; other site 718254005893 putative phosphate binding site [ion binding]; other site 718254005894 putative catalytic site [active] 718254005895 putative phosphate binding site [ion binding]; other site 718254005896 putative metal binding site [ion binding]; other site 718254005897 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 718254005898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254005899 putative substrate translocation pore; other site 718254005900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254005901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254005902 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 718254005903 putative effector binding pocket; other site 718254005904 dimerization interface [polypeptide binding]; other site 718254005905 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254005906 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254005907 active site 718254005908 catalytic tetrad [active] 718254005909 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 718254005910 hypothetical protein; Provisional; Region: PRK05423 718254005911 Predicted membrane protein [Function unknown]; Region: COG1289 718254005912 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 718254005913 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 718254005914 trimer interface [polypeptide binding]; other site 718254005915 putative metal binding site [ion binding]; other site 718254005916 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 718254005917 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 718254005918 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 718254005919 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 718254005920 shikimate binding site; other site 718254005921 NAD(P) binding site [chemical binding]; other site 718254005922 hypothetical protein; Validated; Region: PRK03430 718254005923 hypothetical protein; Provisional; Region: PRK10736 718254005924 DNA protecting protein DprA; Region: dprA; TIGR00732 718254005925 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 718254005926 active site 718254005927 catalytic residues [active] 718254005928 metal binding site [ion binding]; metal-binding site 718254005929 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 718254005930 16S rRNA methyltransferase B; Provisional; Region: PRK10901 718254005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254005932 S-adenosylmethionine binding site [chemical binding]; other site 718254005933 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 718254005934 TrkA-N domain; Region: TrkA_N; pfam02254 718254005935 TrkA-C domain; Region: TrkA_C; pfam02080 718254005936 TrkA-N domain; Region: TrkA_N; pfam02254 718254005937 TrkA-C domain; Region: TrkA_C; pfam02080 718254005938 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 718254005939 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 718254005940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 718254005941 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 718254005942 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 718254005943 DNA binding residues [nucleotide binding] 718254005944 dimer interface [polypeptide binding]; other site 718254005945 metal binding site [ion binding]; metal-binding site 718254005946 hypothetical protein; Provisional; Region: PRK10203 718254005947 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 718254005948 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 718254005949 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 718254005950 alphaNTD homodimer interface [polypeptide binding]; other site 718254005951 alphaNTD - beta interaction site [polypeptide binding]; other site 718254005952 alphaNTD - beta' interaction site [polypeptide binding]; other site 718254005953 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 718254005954 30S ribosomal protein S11; Validated; Region: PRK05309 718254005955 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 718254005956 SecY translocase; Region: SecY; pfam00344 718254005957 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 718254005958 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 718254005959 23S rRNA binding site [nucleotide binding]; other site 718254005960 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 718254005961 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 718254005962 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 718254005963 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 718254005964 23S rRNA interface [nucleotide binding]; other site 718254005965 5S rRNA interface [nucleotide binding]; other site 718254005966 L27 interface [polypeptide binding]; other site 718254005967 L5 interface [polypeptide binding]; other site 718254005968 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 718254005969 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718254005970 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718254005971 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 718254005972 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 718254005973 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 718254005974 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 718254005975 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 718254005976 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 718254005977 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 718254005978 RNA binding site [nucleotide binding]; other site 718254005979 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 718254005980 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 718254005981 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 718254005982 23S rRNA interface [nucleotide binding]; other site 718254005983 putative translocon interaction site; other site 718254005984 signal recognition particle (SRP54) interaction site; other site 718254005985 L23 interface [polypeptide binding]; other site 718254005986 trigger factor interaction site; other site 718254005987 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 718254005988 23S rRNA interface [nucleotide binding]; other site 718254005989 5S rRNA interface [nucleotide binding]; other site 718254005990 putative antibiotic binding site [chemical binding]; other site 718254005991 L25 interface [polypeptide binding]; other site 718254005992 L27 interface [polypeptide binding]; other site 718254005993 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 718254005994 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 718254005995 G-X-X-G motif; other site 718254005996 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 718254005997 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 718254005998 protein-rRNA interface [nucleotide binding]; other site 718254005999 putative translocon binding site; other site 718254006000 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 718254006001 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 718254006002 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 718254006003 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 718254006004 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 718254006005 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 718254006006 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 718254006007 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 718254006008 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 718254006009 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 718254006010 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 718254006011 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 718254006012 heme binding site [chemical binding]; other site 718254006013 ferroxidase diiron center [ion binding]; other site 718254006014 ferroxidase pore; other site 718254006015 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 718254006016 elongation factor G; Reviewed; Region: PRK00007 718254006017 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 718254006018 G1 box; other site 718254006019 putative GEF interaction site [polypeptide binding]; other site 718254006020 GTP/Mg2+ binding site [chemical binding]; other site 718254006021 Switch I region; other site 718254006022 G2 box; other site 718254006023 G3 box; other site 718254006024 Switch II region; other site 718254006025 G4 box; other site 718254006026 G5 box; other site 718254006027 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 718254006028 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 718254006029 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 718254006030 30S ribosomal protein S7; Validated; Region: PRK05302 718254006031 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 718254006032 S17 interaction site [polypeptide binding]; other site 718254006033 S8 interaction site; other site 718254006034 16S rRNA interaction site [nucleotide binding]; other site 718254006035 streptomycin interaction site [chemical binding]; other site 718254006036 23S rRNA interaction site [nucleotide binding]; other site 718254006037 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 718254006038 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 718254006039 sulfur relay protein TusC; Validated; Region: PRK00211 718254006040 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 718254006041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 718254006042 YheO-like PAS domain; Region: PAS_6; pfam08348 718254006043 HTH domain; Region: HTH_22; pfam13309 718254006044 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 718254006045 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 718254006046 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718254006047 phi X174 lysis protein; Provisional; Region: PRK02793 718254006048 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 718254006049 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718254006050 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 718254006051 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 718254006052 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 718254006053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254006054 Walker A/P-loop; other site 718254006055 ATP binding site [chemical binding]; other site 718254006056 Q-loop/lid; other site 718254006057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254006058 ABC transporter signature motif; other site 718254006059 Walker B; other site 718254006060 D-loop; other site 718254006061 ABC transporter; Region: ABC_tran_2; pfam12848 718254006062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718254006063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254006064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254006065 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 718254006066 putative dimerization interface [polypeptide binding]; other site 718254006067 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 718254006068 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 718254006069 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 718254006070 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 718254006071 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 718254006072 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 718254006073 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 718254006074 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 718254006075 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 718254006076 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 718254006077 Coenzyme A transferase; Region: CoA_trans; cl17247 718254006078 putative hydrolase; Provisional; Region: PRK10985 718254006079 hypothetical protein; Provisional; Region: PRK04966 718254006080 hypothetical protein; Provisional; Region: PRK10738 718254006081 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 718254006082 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 718254006083 ligand binding site [chemical binding]; other site 718254006084 flexible hinge region; other site 718254006085 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 718254006086 putative switch regulator; other site 718254006087 non-specific DNA interactions [nucleotide binding]; other site 718254006088 DNA binding site [nucleotide binding] 718254006089 sequence specific DNA binding site [nucleotide binding]; other site 718254006090 putative cAMP binding site [chemical binding]; other site 718254006091 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 718254006092 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 718254006093 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718254006094 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 718254006095 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718254006096 inhibitor-cofactor binding pocket; inhibition site 718254006097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254006098 catalytic residue [active] 718254006099 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 718254006100 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 718254006101 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 718254006102 substrate binding site [chemical binding]; other site 718254006103 putative transporter; Provisional; Region: PRK03699 718254006104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254006105 putative substrate translocation pore; other site 718254006106 nitrite reductase subunit NirD; Provisional; Region: PRK14989 718254006107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254006108 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 718254006109 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 718254006110 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 718254006111 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 718254006112 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 718254006113 active site 718254006114 HIGH motif; other site 718254006115 dimer interface [polypeptide binding]; other site 718254006116 KMSKS motif; other site 718254006117 phosphoglycolate phosphatase; Provisional; Region: PRK13222 718254006118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254006119 motif II; other site 718254006120 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 718254006121 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 718254006122 substrate binding site [chemical binding]; other site 718254006123 hexamer interface [polypeptide binding]; other site 718254006124 metal binding site [ion binding]; metal-binding site 718254006125 DNA adenine methylase; Provisional; Region: PRK10904 718254006126 cell division protein DamX; Validated; Region: PRK10905 718254006127 shikimate kinase; Reviewed; Region: aroK; PRK00131 718254006128 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 718254006129 ADP binding site [chemical binding]; other site 718254006130 magnesium binding site [ion binding]; other site 718254006131 putative shikimate binding site; other site 718254006132 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 718254006133 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 718254006134 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 718254006135 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 718254006136 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 718254006137 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718254006138 ADP-ribose binding site [chemical binding]; other site 718254006139 dimer interface [polypeptide binding]; other site 718254006140 active site 718254006141 nudix motif; other site 718254006142 metal binding site [ion binding]; metal-binding site 718254006143 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 718254006144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254006145 motif II; other site 718254006146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718254006147 RNA binding surface [nucleotide binding]; other site 718254006148 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 718254006149 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 718254006150 dimerization interface [polypeptide binding]; other site 718254006151 domain crossover interface; other site 718254006152 redox-dependent activation switch; other site 718254006153 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 718254006154 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 718254006155 active site 718254006156 substrate-binding site [chemical binding]; other site 718254006157 metal-binding site [ion binding] 718254006158 ATP binding site [chemical binding]; other site 718254006159 osmolarity response regulator; Provisional; Region: ompR; PRK09468 718254006160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254006161 active site 718254006162 phosphorylation site [posttranslational modification] 718254006163 intermolecular recognition site; other site 718254006164 dimerization interface [polypeptide binding]; other site 718254006165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254006166 DNA binding site [nucleotide binding] 718254006167 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 718254006168 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 718254006169 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 718254006170 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 718254006171 RNA binding site [nucleotide binding]; other site 718254006172 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 718254006173 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 718254006174 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 718254006175 G1 box; other site 718254006176 GTP/Mg2+ binding site [chemical binding]; other site 718254006177 Switch I region; other site 718254006178 G2 box; other site 718254006179 G3 box; other site 718254006180 Switch II region; other site 718254006181 G4 box; other site 718254006182 G5 box; other site 718254006183 Nucleoside recognition; Region: Gate; pfam07670 718254006184 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 718254006185 Nucleoside recognition; Region: Gate; pfam07670 718254006186 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 718254006187 carboxylesterase BioH; Provisional; Region: PRK10349 718254006188 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 718254006189 DNA utilization protein GntX; Provisional; Region: PRK11595 718254006190 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718254006191 active site 718254006192 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 718254006193 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 718254006194 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 718254006195 high-affinity gluconate transporter; Provisional; Region: PRK14984 718254006196 gluconate transporter; Region: gntP; TIGR00791 718254006197 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 718254006198 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 718254006199 maltodextrin phosphorylase; Provisional; Region: PRK14985 718254006200 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 718254006201 active site pocket [active] 718254006202 transcriptional regulator MalT; Provisional; Region: PRK04841 718254006203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254006204 DNA binding residues [nucleotide binding] 718254006205 dimerization interface [polypeptide binding]; other site 718254006206 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 718254006207 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 718254006208 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254006209 intramembrane serine protease GlpG; Provisional; Region: PRK10907 718254006210 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 718254006211 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 718254006212 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 718254006213 active site residue [active] 718254006214 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 718254006215 glycogen phosphorylase; Provisional; Region: PRK14986 718254006216 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 718254006217 homodimer interface [polypeptide binding]; other site 718254006218 active site pocket [active] 718254006219 glycogen synthase; Provisional; Region: glgA; PRK00654 718254006220 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 718254006221 ADP-binding pocket [chemical binding]; other site 718254006222 homodimer interface [polypeptide binding]; other site 718254006223 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 718254006224 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 718254006225 ligand binding site; other site 718254006226 oligomer interface; other site 718254006227 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 718254006228 dimer interface [polypeptide binding]; other site 718254006229 N-terminal domain interface [polypeptide binding]; other site 718254006230 sulfate 1 binding site; other site 718254006231 glycogen debranching enzyme; Provisional; Region: PRK03705 718254006232 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 718254006233 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 718254006234 active site 718254006235 catalytic site [active] 718254006236 glycogen branching enzyme; Provisional; Region: PRK05402 718254006237 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 718254006238 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 718254006239 active site 718254006240 catalytic site [active] 718254006241 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 718254006242 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 718254006243 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718254006244 putative antibiotic transporter; Provisional; Region: PRK10739 718254006245 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 718254006246 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 718254006247 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254006248 DNA binding site [nucleotide binding] 718254006249 domain linker motif; other site 718254006250 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 718254006251 putative ligand binding site [chemical binding]; other site 718254006252 putative dimerization interface [polypeptide binding]; other site 718254006253 Pirin-related protein [General function prediction only]; Region: COG1741 718254006254 Pirin; Region: Pirin; pfam02678 718254006255 putative oxidoreductase; Provisional; Region: PRK10206 718254006256 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718254006257 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 718254006258 putative acetyltransferase YhhY; Provisional; Region: PRK10140 718254006259 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718254006260 Coenzyme A binding pocket [chemical binding]; other site 718254006261 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 718254006262 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 718254006263 hypothetical protein; Provisional; Region: PRK10350 718254006264 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 718254006265 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 718254006266 putative active site [active] 718254006267 catalytic site [active] 718254006268 putative metal binding site [ion binding]; other site 718254006269 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 718254006270 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 718254006271 Walker A/P-loop; other site 718254006272 ATP binding site [chemical binding]; other site 718254006273 Q-loop/lid; other site 718254006274 ABC transporter signature motif; other site 718254006275 Walker B; other site 718254006276 D-loop; other site 718254006277 H-loop/switch region; other site 718254006278 TOBE domain; Region: TOBE_2; pfam08402 718254006279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 718254006280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254006281 dimer interface [polypeptide binding]; other site 718254006282 conserved gate region; other site 718254006283 ABC-ATPase subunit interface; other site 718254006284 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 718254006285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254006286 putative PBP binding loops; other site 718254006287 dimer interface [polypeptide binding]; other site 718254006288 ABC-ATPase subunit interface; other site 718254006289 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 718254006290 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 718254006291 Walker A/P-loop; other site 718254006292 ATP binding site [chemical binding]; other site 718254006293 Q-loop/lid; other site 718254006294 ABC transporter signature motif; other site 718254006295 Walker B; other site 718254006296 D-loop; other site 718254006297 H-loop/switch region; other site 718254006298 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 718254006299 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 718254006300 Walker A/P-loop; other site 718254006301 ATP binding site [chemical binding]; other site 718254006302 Q-loop/lid; other site 718254006303 ABC transporter signature motif; other site 718254006304 Walker B; other site 718254006305 D-loop; other site 718254006306 H-loop/switch region; other site 718254006307 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 718254006308 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 718254006309 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 718254006310 TM-ABC transporter signature motif; other site 718254006311 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254006312 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 718254006313 TM-ABC transporter signature motif; other site 718254006314 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 718254006315 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 718254006316 dimerization interface [polypeptide binding]; other site 718254006317 ligand binding site [chemical binding]; other site 718254006318 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 718254006319 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 718254006320 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 718254006321 dimerization interface [polypeptide binding]; other site 718254006322 ligand binding site [chemical binding]; other site 718254006323 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 718254006324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718254006325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718254006326 DNA binding residues [nucleotide binding] 718254006327 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 718254006328 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 718254006329 cell division protein FtsE; Provisional; Region: PRK10908 718254006330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254006331 Walker A/P-loop; other site 718254006332 ATP binding site [chemical binding]; other site 718254006333 Q-loop/lid; other site 718254006334 ABC transporter signature motif; other site 718254006335 Walker B; other site 718254006336 D-loop; other site 718254006337 H-loop/switch region; other site 718254006338 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 718254006339 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 718254006340 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 718254006341 P loop; other site 718254006342 GTP binding site [chemical binding]; other site 718254006343 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 718254006344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254006345 S-adenosylmethionine binding site [chemical binding]; other site 718254006346 hypothetical protein; Provisional; Region: PRK10910 718254006347 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 718254006348 Predicted membrane protein [Function unknown]; Region: COG3714 718254006349 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 718254006350 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718254006351 metal-binding site [ion binding] 718254006352 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718254006353 DctM-like transporters; Region: DctM; pfam06808 718254006354 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 718254006355 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 718254006356 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 718254006357 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 718254006358 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 718254006359 CPxP motif; other site 718254006360 hypothetical protein; Provisional; Region: PRK11212 718254006361 hypothetical protein; Provisional; Region: PRK11615 718254006362 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 718254006363 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718254006364 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718254006365 putative acyl-acceptor binding pocket; other site 718254006366 Phosphopantetheine attachment site; Region: PP-binding; cl09936 718254006367 acyl carrier protein; Provisional; Region: PRK05350 718254006368 Predicted membrane protein [Function unknown]; Region: COG4648 718254006369 Predicted membrane protein [Function unknown]; Region: COG4648 718254006370 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 718254006371 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 718254006372 Predicted exporter [General function prediction only]; Region: COG4258 718254006373 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 718254006374 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 718254006375 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718254006376 dimer interface [polypeptide binding]; other site 718254006377 active site 718254006378 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 718254006379 active site 2 [active] 718254006380 active site 1 [active] 718254006381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254006382 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 718254006383 NAD(P) binding site [chemical binding]; other site 718254006384 active site 718254006385 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 718254006386 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718254006387 dimer interface [polypeptide binding]; other site 718254006388 active site 718254006389 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 718254006390 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 718254006391 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 718254006392 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 718254006393 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 718254006394 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 718254006395 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 718254006396 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 718254006397 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 718254006398 active site 718254006399 substrate binding site [chemical binding]; other site 718254006400 cosubstrate binding site; other site 718254006401 catalytic site [active] 718254006402 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 718254006403 active site 718254006404 hexamer interface [polypeptide binding]; other site 718254006405 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 718254006406 NAD binding site [chemical binding]; other site 718254006407 substrate binding site [chemical binding]; other site 718254006408 active site 718254006409 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 718254006410 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718254006411 inhibitor-cofactor binding pocket; inhibition site 718254006412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254006413 catalytic residue [active] 718254006414 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 718254006415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254006416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254006417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254006418 dimerization interface [polypeptide binding]; other site 718254006419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 718254006420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254006421 NAD(P) binding site [chemical binding]; other site 718254006422 active site 718254006423 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718254006424 Integral membrane protein TerC family; Region: TerC; cl10468 718254006425 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718254006426 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718254006427 universal stress protein UspB; Provisional; Region: PRK04960 718254006428 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718254006429 Ligand Binding Site [chemical binding]; other site 718254006430 oligopeptidase A; Provisional; Region: PRK10911 718254006431 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 718254006432 active site 718254006433 Zn binding site [ion binding]; other site 718254006434 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 718254006435 glutathione reductase; Validated; Region: PRK06116 718254006436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718254006437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254006438 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718254006439 trehalase; Provisional; Region: treF; PRK13270 718254006440 Trehalase; Region: Trehalase; pfam01204 718254006441 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 718254006442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718254006443 Coenzyme A binding pocket [chemical binding]; other site 718254006444 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 718254006445 catalytic residue [active] 718254006446 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718254006447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254006448 DNA binding residues [nucleotide binding] 718254006449 dimerization interface [polypeptide binding]; other site 718254006450 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 718254006451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254006452 NAD(P) binding site [chemical binding]; other site 718254006453 active site 718254006454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254006455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254006456 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 718254006457 putative effector binding pocket; other site 718254006458 putative dimerization interface [polypeptide binding]; other site 718254006459 inner membrane protein YhjD; Region: TIGR00766 718254006460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254006461 metabolite-proton symporter; Region: 2A0106; TIGR00883 718254006462 putative substrate translocation pore; other site 718254006463 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 718254006464 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 718254006465 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254006466 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718254006467 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 718254006468 substrate binding site [chemical binding]; other site 718254006469 ATP binding site [chemical binding]; other site 718254006470 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 718254006471 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718254006472 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 718254006473 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718254006474 putative diguanylate cyclase; Provisional; Region: PRK13561 718254006475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254006476 metal binding site [ion binding]; metal-binding site 718254006477 active site 718254006478 I-site; other site 718254006479 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254006480 endo-1,4-D-glucanase; Provisional; Region: PRK11097 718254006481 cellulose synthase regulator protein; Provisional; Region: PRK11114 718254006482 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 718254006483 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 718254006484 DXD motif; other site 718254006485 PilZ domain; Region: PilZ; pfam07238 718254006486 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 718254006487 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 718254006488 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 718254006489 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 718254006490 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 718254006491 FAD binding domain; Region: FAD_binding_4; pfam01565 718254006492 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 718254006493 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718254006494 putative glycosyl transferase; Provisional; Region: PRK10018 718254006495 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 718254006496 active site 718254006497 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 718254006498 HNH endonuclease; Region: HNH_3; pfam13392 718254006499 AP2 domain; Region: AP2; pfam00847 718254006500 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 718254006501 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 718254006502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254006503 non-specific DNA binding site [nucleotide binding]; other site 718254006504 Predicted transcriptional regulator [Transcription]; Region: COG2932 718254006505 salt bridge; other site 718254006506 sequence-specific DNA binding site [nucleotide binding]; other site 718254006507 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718254006508 Catalytic site [active] 718254006509 HNH endonuclease; Region: HNH_3; pfam13392 718254006510 AP2 domain; Region: AP2; pfam00847 718254006511 HNH endonuclease; Region: HNH_3; pfam13392 718254006512 Terminase small subunit; Region: Terminase_2; pfam03592 718254006513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 718254006514 Terminase-like family; Region: Terminase_6; pfam03237 718254006515 Uncharacterized conserved protein [Function unknown]; Region: COG5323 718254006516 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 718254006517 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 718254006518 hypothetical protein; Provisional; Region: PRK10723 718254006519 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 718254006520 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 718254006521 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 718254006522 30S subunit binding site; other site 718254006523 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 718254006524 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 718254006525 Prephenate dehydratase; Region: PDT; pfam00800 718254006526 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 718254006527 putative L-Phe binding site [chemical binding]; other site 718254006528 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 718254006529 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 718254006530 Chorismate mutase type II; Region: CM_2; cl00693 718254006531 prephenate dehydrogenase; Validated; Region: PRK08507 718254006532 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 718254006533 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718254006534 lipoprotein; Provisional; Region: PRK11443 718254006535 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 718254006536 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 718254006537 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 718254006538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254006539 metal binding site [ion binding]; metal-binding site 718254006540 active site 718254006541 I-site; other site 718254006542 putative outer membrane lipoprotein; Provisional; Region: PRK09967 718254006543 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718254006544 ligand binding site [chemical binding]; other site 718254006545 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 718254006546 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 718254006547 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 718254006548 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 718254006549 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 718254006550 RimM N-terminal domain; Region: RimM; pfam01782 718254006551 PRC-barrel domain; Region: PRC; pfam05239 718254006552 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 718254006553 signal recognition particle protein; Provisional; Region: PRK10867 718254006554 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 718254006555 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 718254006556 P loop; other site 718254006557 GTP binding site [chemical binding]; other site 718254006558 Signal peptide binding domain; Region: SRP_SPB; pfam02978 718254006559 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 718254006560 hypothetical protein; Provisional; Region: PRK11573 718254006561 Domain of unknown function DUF21; Region: DUF21; pfam01595 718254006562 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718254006563 Transporter associated domain; Region: CorC_HlyC; smart01091 718254006564 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 718254006565 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 718254006566 dimer interface [polypeptide binding]; other site 718254006567 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 718254006568 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 718254006569 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 718254006570 recombination and repair protein; Provisional; Region: PRK10869 718254006571 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 718254006572 Walker A/P-loop; other site 718254006573 ATP binding site [chemical binding]; other site 718254006574 Q-loop/lid; other site 718254006575 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 718254006576 ABC transporter signature motif; other site 718254006577 Walker B; other site 718254006578 D-loop; other site 718254006579 H-loop/switch region; other site 718254006580 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 718254006581 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 718254006582 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 718254006583 putative coenzyme Q binding site [chemical binding]; other site 718254006584 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 718254006585 SmpB-tmRNA interface; other site 718254006586 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718254006587 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 718254006588 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718254006589 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 718254006590 substrate binding site [chemical binding]; other site 718254006591 dimer interface [polypeptide binding]; other site 718254006592 ATP binding site [chemical binding]; other site 718254006593 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 718254006594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254006595 dimer interface [polypeptide binding]; other site 718254006596 conserved gate region; other site 718254006597 ABC-ATPase subunit interface; other site 718254006598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 718254006599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 718254006600 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 718254006601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 718254006602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 718254006603 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 718254006604 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 718254006605 Walker A/P-loop; other site 718254006606 ATP binding site [chemical binding]; other site 718254006607 Q-loop/lid; other site 718254006608 ABC transporter signature motif; other site 718254006609 Walker B; other site 718254006610 D-loop; other site 718254006611 H-loop/switch region; other site 718254006612 TOBE domain; Region: TOBE_2; pfam08402 718254006613 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 718254006614 chemotaxis protein CheA; Provisional; Region: PRK10547 718254006615 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718254006616 putative binding surface; other site 718254006617 active site 718254006618 CheY binding; Region: CheY-binding; pfam09078 718254006619 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 718254006620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254006621 ATP binding site [chemical binding]; other site 718254006622 Mg2+ binding site [ion binding]; other site 718254006623 G-X-G motif; other site 718254006624 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 718254006625 transcriptional activator FlhC; Provisional; Region: PRK12722 718254006626 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 718254006627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718254006628 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718254006629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718254006630 DNA binding residues [nucleotide binding] 718254006631 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 718254006632 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718254006633 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 718254006634 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 718254006635 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 718254006636 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 718254006637 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 718254006638 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 718254006639 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 718254006640 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 718254006641 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254006642 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718254006643 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 718254006644 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254006645 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 718254006646 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 718254006647 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254006648 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 718254006649 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718254006650 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 718254006651 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 718254006652 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 718254006653 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718254006654 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 718254006655 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 718254006656 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 718254006657 SAF-like; Region: SAF_2; pfam13144 718254006658 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 718254006659 FlgN protein; Region: FlgN; cl09176 718254006660 Flagellar protein FliS; Region: FliS; cl00654 718254006661 flagellar capping protein; Reviewed; Region: fliD; PRK08032 718254006662 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 718254006663 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 718254006664 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718254006665 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 718254006666 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 718254006667 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 718254006668 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 718254006669 flagellar motor switch protein; Validated; Region: fliN; PRK05698 718254006670 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 718254006671 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 718254006672 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 718254006673 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 718254006674 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 718254006675 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 718254006676 flagellar assembly protein H; Validated; Region: fliH; PRK05687 718254006677 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 718254006678 Flagellar assembly protein FliH; Region: FliH; pfam02108 718254006679 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 718254006680 FliG C-terminal domain; Region: FliG_C; pfam01706 718254006681 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 718254006682 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 718254006683 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 718254006684 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 718254006685 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 718254006686 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 718254006687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254006688 S-adenosylmethionine binding site [chemical binding]; other site 718254006689 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 718254006690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254006691 active site 718254006692 phosphorylation site [posttranslational modification] 718254006693 intermolecular recognition site; other site 718254006694 dimerization interface [polypeptide binding]; other site 718254006695 chemotaxis regulator CheZ; Provisional; Region: PRK11166 718254006696 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 718254006697 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 718254006698 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 718254006699 FHIPEP family; Region: FHIPEP; pfam00771 718254006700 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 718254006701 Amidase; Region: Amidase; cl11426 718254006702 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 718254006703 histidinol dehydrogenase; Region: hisD; TIGR00069 718254006704 NAD binding site [chemical binding]; other site 718254006705 dimerization interface [polypeptide binding]; other site 718254006706 product binding site; other site 718254006707 substrate binding site [chemical binding]; other site 718254006708 zinc binding site [ion binding]; other site 718254006709 catalytic residues [active] 718254006710 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 718254006711 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 718254006712 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 718254006713 SnoaL-like domain; Region: SnoaL_2; pfam12680 718254006714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254006715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254006716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254006717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 718254006718 NAD(P) binding site [chemical binding]; other site 718254006719 active site 718254006720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 718254006721 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 718254006722 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 718254006723 putative active site [active] 718254006724 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 718254006725 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718254006726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254006727 Walker A/P-loop; other site 718254006728 ATP binding site [chemical binding]; other site 718254006729 Q-loop/lid; other site 718254006730 ABC transporter signature motif; other site 718254006731 Walker B; other site 718254006732 D-loop; other site 718254006733 H-loop/switch region; other site 718254006734 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 718254006735 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 718254006736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254006737 sequence-specific DNA binding site [nucleotide binding]; other site 718254006738 salt bridge; other site 718254006739 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 718254006740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254006741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254006742 homodimer interface [polypeptide binding]; other site 718254006743 catalytic residue [active] 718254006744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254006745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254006746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254006747 dimerization interface [polypeptide binding]; other site 718254006748 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 718254006749 putative NAD(P) binding site [chemical binding]; other site 718254006750 homodimer interface [polypeptide binding]; other site 718254006751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254006752 S-adenosylmethionine binding site [chemical binding]; other site 718254006753 putative deaminase; Validated; Region: PRK06846 718254006754 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 718254006755 active site 718254006756 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 718254006757 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 718254006758 putative substrate binding site [chemical binding]; other site 718254006759 nucleotide binding site [chemical binding]; other site 718254006760 nucleotide binding site [chemical binding]; other site 718254006761 homodimer interface [polypeptide binding]; other site 718254006762 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 718254006763 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 718254006764 CoA binding domain; Region: CoA_binding; pfam02629 718254006765 CoA-ligase; Region: Ligase_CoA; pfam00549 718254006766 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 718254006767 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 718254006768 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 718254006769 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 718254006770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254006771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254006772 dimerization interface [polypeptide binding]; other site 718254006773 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 718254006774 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 718254006775 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 718254006776 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 718254006777 hypothetical protein; Provisional; Region: PRK10556 718254006778 hypothetical protein; Provisional; Region: PRK10132 718254006779 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 718254006780 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 718254006781 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 718254006782 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 718254006783 dimer interface [polypeptide binding]; other site 718254006784 putative radical transfer pathway; other site 718254006785 diiron center [ion binding]; other site 718254006786 tyrosyl radical; other site 718254006787 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 718254006788 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 718254006789 Walker A/P-loop; other site 718254006790 ATP binding site [chemical binding]; other site 718254006791 Q-loop/lid; other site 718254006792 ABC transporter signature motif; other site 718254006793 Walker B; other site 718254006794 D-loop; other site 718254006795 H-loop/switch region; other site 718254006796 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 718254006797 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 718254006798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254006799 dimer interface [polypeptide binding]; other site 718254006800 conserved gate region; other site 718254006801 putative PBP binding loops; other site 718254006802 ABC-ATPase subunit interface; other site 718254006803 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 718254006804 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 718254006805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254006806 transcriptional repressor MprA; Provisional; Region: PRK10870 718254006807 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 718254006808 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 718254006809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254006810 putative substrate translocation pore; other site 718254006811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254006812 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 718254006813 active site 718254006814 catalytic residues [active] 718254006815 metal binding site [ion binding]; metal-binding site 718254006816 Cupin domain; Region: Cupin_2; pfam07883 718254006817 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 718254006818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254006819 S-ribosylhomocysteinase; Provisional; Region: PRK02260 718254006820 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 718254006821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254006822 motif II; other site 718254006823 carbon storage regulator; Provisional; Region: PRK01712 718254006824 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 718254006825 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 718254006826 motif 1; other site 718254006827 active site 718254006828 motif 2; other site 718254006829 motif 3; other site 718254006830 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 718254006831 DHHA1 domain; Region: DHHA1; pfam02272 718254006832 recombinase A; Provisional; Region: recA; PRK09354 718254006833 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 718254006834 hexamer interface [polypeptide binding]; other site 718254006835 Walker A motif; other site 718254006836 ATP binding site [chemical binding]; other site 718254006837 Walker B motif; other site 718254006838 hypothetical protein; Validated; Region: PRK03661 718254006839 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 718254006840 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 718254006841 metal binding site [ion binding]; metal-binding site 718254006842 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718254006843 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254006844 ABC-ATPase subunit interface; other site 718254006845 dimer interface [polypeptide binding]; other site 718254006846 putative PBP binding regions; other site 718254006847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718254006848 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 718254006849 Transglycosylase SLT domain; Region: SLT_2; pfam13406 718254006850 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718254006851 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718254006852 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 718254006853 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 718254006854 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 718254006855 Nucleoside recognition; Region: Gate; pfam07670 718254006856 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 718254006857 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 718254006858 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 718254006859 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 718254006860 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254006861 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 718254006862 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 718254006863 putative active site [active] 718254006864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 718254006865 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 718254006866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254006867 Walker A motif; other site 718254006868 ATP binding site [chemical binding]; other site 718254006869 Walker B motif; other site 718254006870 arginine finger; other site 718254006871 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 718254006872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 718254006873 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 718254006874 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 718254006875 iron binding site [ion binding]; other site 718254006876 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 718254006877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254006878 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 718254006879 Acylphosphatase; Region: Acylphosphatase; pfam00708 718254006880 HypF finger; Region: zf-HYPF; pfam07503 718254006881 HypF finger; Region: zf-HYPF; pfam07503 718254006882 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 718254006883 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 718254006884 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 718254006885 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254006886 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254006887 DNA binding site [nucleotide binding] 718254006888 domain linker motif; other site 718254006889 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 718254006890 dimerization interface (closed form) [polypeptide binding]; other site 718254006891 ligand binding site [chemical binding]; other site 718254006892 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254006893 active site turn [active] 718254006894 phosphorylation site [posttranslational modification] 718254006895 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 718254006896 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 718254006897 beta-galactosidase; Region: BGL; TIGR03356 718254006898 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 718254006899 nickel binding site [ion binding]; other site 718254006900 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 718254006901 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 718254006902 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 718254006903 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718254006904 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 718254006905 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 718254006906 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 718254006907 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 718254006908 NADH dehydrogenase; Region: NADHdh; cl00469 718254006909 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 718254006910 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718254006911 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 718254006912 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 718254006913 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 718254006914 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 718254006915 hydrogenase assembly chaperone; Provisional; Region: PRK10409 718254006916 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 718254006917 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 718254006918 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 718254006919 dimerization interface [polypeptide binding]; other site 718254006920 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 718254006921 ATP binding site [chemical binding]; other site 718254006922 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 718254006923 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 718254006924 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 718254006925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254006926 Walker A motif; other site 718254006927 ATP binding site [chemical binding]; other site 718254006928 Walker B motif; other site 718254006929 arginine finger; other site 718254006930 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 718254006931 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 718254006932 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 718254006933 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 718254006934 MutS domain I; Region: MutS_I; pfam01624 718254006935 MutS domain II; Region: MutS_II; pfam05188 718254006936 MutS domain III; Region: MutS_III; pfam05192 718254006937 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 718254006938 Walker A/P-loop; other site 718254006939 ATP binding site [chemical binding]; other site 718254006940 Q-loop/lid; other site 718254006941 ABC transporter signature motif; other site 718254006942 Walker B; other site 718254006943 D-loop; other site 718254006944 H-loop/switch region; other site 718254006945 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 718254006946 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 718254006947 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 718254006948 Flavoprotein; Region: Flavoprotein; pfam02441 718254006949 MarR family; Region: MarR_2; cl17246 718254006950 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 718254006951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254006952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254006953 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 718254006954 putative effector binding pocket; other site 718254006955 dimerization interface [polypeptide binding]; other site 718254006956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254006957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254006958 putative substrate translocation pore; other site 718254006959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 718254006960 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 718254006961 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 718254006962 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718254006963 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718254006964 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718254006965 DNA binding residues [nucleotide binding] 718254006966 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 718254006967 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718254006968 Peptidase family M23; Region: Peptidase_M23; pfam01551 718254006969 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 718254006970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254006971 S-adenosylmethionine binding site [chemical binding]; other site 718254006972 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 718254006973 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 718254006974 Permutation of conserved domain; other site 718254006975 active site 718254006976 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 718254006977 homotrimer interaction site [polypeptide binding]; other site 718254006978 zinc binding site [ion binding]; other site 718254006979 CDP-binding sites; other site 718254006980 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 718254006981 substrate binding site; other site 718254006982 dimer interface; other site 718254006983 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 718254006984 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 718254006985 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 718254006986 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 718254006987 ligand-binding site [chemical binding]; other site 718254006988 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 718254006989 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 718254006990 CysD dimerization site [polypeptide binding]; other site 718254006991 G1 box; other site 718254006992 putative GEF interaction site [polypeptide binding]; other site 718254006993 GTP/Mg2+ binding site [chemical binding]; other site 718254006994 Switch I region; other site 718254006995 G2 box; other site 718254006996 G3 box; other site 718254006997 Switch II region; other site 718254006998 G4 box; other site 718254006999 G5 box; other site 718254007000 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 718254007001 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 718254007002 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 718254007003 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 718254007004 Active Sites [active] 718254007005 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 718254007006 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 718254007007 metal binding site [ion binding]; metal-binding site 718254007008 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 718254007009 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 718254007010 Active Sites [active] 718254007011 sulfite reductase subunit beta; Provisional; Region: PRK13504 718254007012 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 718254007013 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 718254007014 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 718254007015 Flavodoxin; Region: Flavodoxin_1; pfam00258 718254007016 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 718254007017 FAD binding pocket [chemical binding]; other site 718254007018 FAD binding motif [chemical binding]; other site 718254007019 catalytic residues [active] 718254007020 NAD binding pocket [chemical binding]; other site 718254007021 phosphate binding motif [ion binding]; other site 718254007022 beta-alpha-beta structure motif; other site 718254007023 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 718254007024 active site 718254007025 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 718254007026 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 718254007027 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 718254007028 metal binding site [ion binding]; metal-binding site 718254007029 putative dimer interface [polypeptide binding]; other site 718254007030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254007031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007032 putative substrate translocation pore; other site 718254007033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007034 putative substrate translocation pore; other site 718254007035 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 718254007036 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 718254007037 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 718254007038 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 718254007039 putative active site cavity [active] 718254007040 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 718254007041 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254007042 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254007043 active site turn [active] 718254007044 phosphorylation site [posttranslational modification] 718254007045 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 718254007046 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254007047 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254007048 putative active site [active] 718254007049 enolase; Provisional; Region: eno; PRK00077 718254007050 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 718254007051 dimer interface [polypeptide binding]; other site 718254007052 metal binding site [ion binding]; metal-binding site 718254007053 substrate binding pocket [chemical binding]; other site 718254007054 CTP synthetase; Validated; Region: pyrG; PRK05380 718254007055 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 718254007056 Catalytic site [active] 718254007057 active site 718254007058 UTP binding site [chemical binding]; other site 718254007059 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 718254007060 active site 718254007061 putative oxyanion hole; other site 718254007062 catalytic triad [active] 718254007063 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 718254007064 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 718254007065 homodimer interface [polypeptide binding]; other site 718254007066 metal binding site [ion binding]; metal-binding site 718254007067 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 718254007068 homodimer interface [polypeptide binding]; other site 718254007069 active site 718254007070 putative chemical substrate binding site [chemical binding]; other site 718254007071 metal binding site [ion binding]; metal-binding site 718254007072 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 718254007073 TRAM domain; Region: TRAM; pfam01938 718254007074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254007075 S-adenosylmethionine binding site [chemical binding]; other site 718254007076 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 718254007077 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 718254007078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254007079 dimerization interface [polypeptide binding]; other site 718254007080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254007081 dimer interface [polypeptide binding]; other site 718254007082 phosphorylation site [posttranslational modification] 718254007083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254007084 ATP binding site [chemical binding]; other site 718254007085 Mg2+ binding site [ion binding]; other site 718254007086 G-X-G motif; other site 718254007087 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 718254007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254007089 active site 718254007090 phosphorylation site [posttranslational modification] 718254007091 intermolecular recognition site; other site 718254007092 dimerization interface [polypeptide binding]; other site 718254007093 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718254007094 putative binding surface; other site 718254007095 active site 718254007096 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 718254007097 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 718254007098 active site 718254007099 tetramer interface [polypeptide binding]; other site 718254007100 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 718254007101 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 718254007102 active site 718254007103 tetramer interface [polypeptide binding]; other site 718254007104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007105 D-galactonate transporter; Region: 2A0114; TIGR00893 718254007106 putative substrate translocation pore; other site 718254007107 flavodoxin; Provisional; Region: PRK08105 718254007108 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718254007109 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 718254007110 probable active site [active] 718254007111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 718254007112 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 718254007113 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 718254007114 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 718254007115 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 718254007116 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718254007117 serine transporter; Region: stp; TIGR00814 718254007118 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 718254007119 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 718254007120 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 718254007121 flap endonuclease-like protein; Provisional; Region: PRK09482 718254007122 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 718254007123 active site 718254007124 metal binding site 1 [ion binding]; metal-binding site 718254007125 putative 5' ssDNA interaction site; other site 718254007126 metal binding site 3; metal-binding site 718254007127 metal binding site 2 [ion binding]; metal-binding site 718254007128 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 718254007129 putative DNA binding site [nucleotide binding]; other site 718254007130 putative metal binding site [ion binding]; other site 718254007131 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 718254007132 FtsJ-like methyltransferase; Region: FtsJ; cl17430 718254007133 hypothetical protein; Provisional; Region: PRK10873 718254007134 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 718254007135 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 718254007136 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 718254007137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718254007138 catalytic residue [active] 718254007139 Fe-S metabolism associated domain; Region: SufE; cl00951 718254007140 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 718254007141 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 718254007142 putative ATP binding site [chemical binding]; other site 718254007143 putative substrate interface [chemical binding]; other site 718254007144 murein transglycosylase A; Provisional; Region: mltA; PRK11162 718254007145 MltA specific insert domain; Region: MltA; pfam03562 718254007146 3D domain; Region: 3D; pfam06725 718254007147 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 718254007148 AMIN domain; Region: AMIN; pfam11741 718254007149 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718254007150 active site 718254007151 metal binding site [ion binding]; metal-binding site 718254007152 N-acetylglutamate synthase; Validated; Region: PRK05279 718254007153 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 718254007154 putative feedback inhibition sensing region; other site 718254007155 putative nucleotide binding site [chemical binding]; other site 718254007156 putative substrate binding site [chemical binding]; other site 718254007157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254007158 Coenzyme A binding pocket [chemical binding]; other site 718254007159 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 718254007160 protease3; Provisional; Region: PRK15101 718254007161 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 718254007162 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718254007163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718254007164 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 718254007165 hypothetical protein; Provisional; Region: PRK10557 718254007166 hypothetical protein; Provisional; Region: PRK10506 718254007167 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 718254007168 thymidylate synthase; Reviewed; Region: thyA; PRK01827 718254007169 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 718254007170 dimerization interface [polypeptide binding]; other site 718254007171 active site 718254007172 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 718254007173 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 718254007174 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 718254007175 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 718254007176 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 718254007177 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 718254007178 RNA pyrophosphohydrolase; Reviewed; Region: PRK00714 718254007179 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 718254007180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254007181 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254007182 active site 718254007183 catalytic tetrad [active] 718254007184 lysophospholipid transporter LplT; Provisional; Region: PRK11195 718254007185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007186 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 718254007187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718254007188 putative acyl-acceptor binding pocket; other site 718254007189 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 718254007190 acyl-activating enzyme (AAE) consensus motif; other site 718254007191 putative AMP binding site [chemical binding]; other site 718254007192 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 718254007193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254007194 DNA binding site [nucleotide binding] 718254007195 domain linker motif; other site 718254007196 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 718254007197 dimerization interface (closed form) [polypeptide binding]; other site 718254007198 ligand binding site [chemical binding]; other site 718254007199 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 718254007200 beta-galactosidase; Region: BGL; TIGR03356 718254007201 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 718254007202 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 718254007203 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254007204 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254007205 DNA binding site [nucleotide binding] 718254007206 domain linker motif; other site 718254007207 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 718254007208 dimerization interface (closed form) [polypeptide binding]; other site 718254007209 ligand binding site [chemical binding]; other site 718254007210 diaminopimelate decarboxylase; Provisional; Region: PRK11165 718254007211 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 718254007212 active site 718254007213 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718254007214 substrate binding site [chemical binding]; other site 718254007215 catalytic residues [active] 718254007216 dimer interface [polypeptide binding]; other site 718254007217 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 718254007218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254007219 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 718254007220 putative dimerization interface [polypeptide binding]; other site 718254007221 putative racemase; Provisional; Region: PRK10200 718254007222 aspartate racemase; Region: asp_race; TIGR00035 718254007223 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 718254007224 LPS O-antigen length regulator; Provisional; Region: PRK10381 718254007225 Chain length determinant protein; Region: Wzz; pfam02706 718254007226 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 718254007227 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 718254007228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254007229 dimer interface [polypeptide binding]; other site 718254007230 conserved gate region; other site 718254007231 putative PBP binding loops; other site 718254007232 ABC-ATPase subunit interface; other site 718254007233 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 718254007234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254007235 dimer interface [polypeptide binding]; other site 718254007236 conserved gate region; other site 718254007237 putative PBP binding loops; other site 718254007238 ABC-ATPase subunit interface; other site 718254007239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254007240 Walker A/P-loop; other site 718254007241 ATP binding site [chemical binding]; other site 718254007242 Q-loop/lid; other site 718254007243 ABC transporter signature motif; other site 718254007244 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 718254007245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254007246 H-loop/switch region; other site 718254007247 TOBE domain; Region: TOBE; pfam03459 718254007248 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 718254007249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 718254007250 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 718254007251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007252 putative substrate translocation pore; other site 718254007253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007254 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 718254007255 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 718254007256 putative acyltransferase; Provisional; Region: PRK05790 718254007257 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 718254007258 dimer interface [polypeptide binding]; other site 718254007259 active site 718254007260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254007261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254007262 LysR substrate binding domain; Region: LysR_substrate; pfam03466 718254007263 dimerization interface [polypeptide binding]; other site 718254007264 Predicted membrane protein [Function unknown]; Region: COG4125 718254007265 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 718254007266 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 718254007267 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718254007268 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 718254007269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254007270 Coenzyme A binding pocket [chemical binding]; other site 718254007271 Uncharacterized conserved protein [Function unknown]; Region: COG3592 718254007272 General stress protein [General function prediction only]; Region: GsiB; COG3729 718254007273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 718254007274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 718254007275 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 718254007276 dimanganese center [ion binding]; other site 718254007277 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 718254007278 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 718254007279 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 718254007280 trehalose synthase; Region: treS_nterm; TIGR02456 718254007281 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 718254007282 active site 718254007283 catalytic site [active] 718254007284 short chain dehydrogenase; Provisional; Region: PRK07109 718254007285 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 718254007286 putative NAD(P) binding site [chemical binding]; other site 718254007287 active site 718254007288 hypothetical protein; Validated; Region: PRK03657 718254007289 Predicted membrane protein [Function unknown]; Region: COG2323 718254007290 hypothetical protein; Provisional; Region: PRK10053 718254007291 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 718254007292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 718254007293 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 718254007294 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 718254007295 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 718254007296 Isochorismatase family; Region: Isochorismatase; pfam00857 718254007297 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 718254007298 catalytic triad [active] 718254007299 dimer interface [polypeptide binding]; other site 718254007300 conserved cis-peptide bond; other site 718254007301 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 718254007302 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718254007303 Peptidase family M23; Region: Peptidase_M23; pfam01551 718254007304 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 718254007305 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 718254007306 active site 718254007307 metal binding site [ion binding]; metal-binding site 718254007308 nudix motif; other site 718254007309 peptide chain release factor 2; Provisional; Region: PRK08787 718254007310 This domain is found in peptide chain release factors; Region: PCRF; smart00937 718254007311 RF-1 domain; Region: RF-1; pfam00472 718254007312 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 718254007313 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 718254007314 dimerization domain [polypeptide binding]; other site 718254007315 dimer interface [polypeptide binding]; other site 718254007316 catalytic residues [active] 718254007317 flavodoxin FldB; Provisional; Region: PRK12359 718254007318 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 718254007319 hypothetical protein; Provisional; Region: PRK10878 718254007320 hemolysin; Provisional; Region: PRK15087 718254007321 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 718254007322 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 718254007323 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254007324 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254007325 putative active site [active] 718254007326 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 718254007327 beta-galactosidase; Region: BGL; TIGR03356 718254007328 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 718254007329 classical (c) SDRs; Region: SDR_c; cd05233 718254007330 NAD(P) binding site [chemical binding]; other site 718254007331 active site 718254007332 glycine dehydrogenase; Provisional; Region: PRK05367 718254007333 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 718254007334 tetramer interface [polypeptide binding]; other site 718254007335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254007336 catalytic residue [active] 718254007337 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 718254007338 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 718254007339 tetramer interface [polypeptide binding]; other site 718254007340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254007341 catalytic residue [active] 718254007342 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 718254007343 lipoyl attachment site [posttranslational modification]; other site 718254007344 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 718254007345 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 718254007346 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 718254007347 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 718254007348 proline aminopeptidase P II; Provisional; Region: PRK10879 718254007349 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 718254007350 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 718254007351 active site 718254007352 hypothetical protein; Reviewed; Region: PRK01736 718254007353 Z-ring-associated protein; Provisional; Region: PRK10972 718254007354 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 718254007355 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 718254007356 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 718254007357 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 718254007358 ligand binding site [chemical binding]; other site 718254007359 NAD binding site [chemical binding]; other site 718254007360 tetramer interface [polypeptide binding]; other site 718254007361 catalytic site [active] 718254007362 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 718254007363 L-serine binding site [chemical binding]; other site 718254007364 ACT domain interface; other site 718254007365 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 718254007366 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718254007367 active site 718254007368 dimer interface [polypeptide binding]; other site 718254007369 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 718254007370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254007371 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 718254007372 putative dimerization interface [polypeptide binding]; other site 718254007373 Uncharacterized conserved protein [Function unknown]; Region: COG2968 718254007374 oxidative stress defense protein; Provisional; Region: PRK11087 718254007375 arginine exporter protein; Provisional; Region: PRK09304 718254007376 mechanosensitive channel MscS; Provisional; Region: PRK10334 718254007377 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718254007378 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 718254007379 Phosphoglycerate kinase; Region: PGK; pfam00162 718254007380 substrate binding site [chemical binding]; other site 718254007381 hinge regions; other site 718254007382 ADP binding site [chemical binding]; other site 718254007383 catalytic site [active] 718254007384 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 718254007385 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 718254007386 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 718254007387 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 718254007388 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 718254007389 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 718254007390 active site 718254007391 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 718254007392 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 718254007393 putative NAD(P) binding site [chemical binding]; other site 718254007394 catalytic Zn binding site [ion binding]; other site 718254007395 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 718254007396 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 718254007397 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254007398 active site 718254007399 phosphorylation site [posttranslational modification] 718254007400 transketolase; Reviewed; Region: PRK12753 718254007401 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 718254007402 TPP-binding site [chemical binding]; other site 718254007403 dimer interface [polypeptide binding]; other site 718254007404 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718254007405 PYR/PP interface [polypeptide binding]; other site 718254007406 dimer interface [polypeptide binding]; other site 718254007407 TPP binding site [chemical binding]; other site 718254007408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718254007409 hypothetical protein; Provisional; Region: PRK07064 718254007410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 718254007411 PYR/PP interface [polypeptide binding]; other site 718254007412 dimer interface [polypeptide binding]; other site 718254007413 TPP binding site [chemical binding]; other site 718254007414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718254007415 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 718254007416 TPP-binding site [chemical binding]; other site 718254007417 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 718254007418 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 718254007419 NAD(P) binding site [chemical binding]; other site 718254007420 catalytic residues [active] 718254007421 L-aspartate dehydrogenase; Provisional; Region: PRK13303 718254007422 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 718254007423 Domain of unknown function DUF108; Region: DUF108; pfam01958 718254007424 short chain dehydrogenase; Provisional; Region: PRK07062 718254007425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254007426 NAD(P) binding site [chemical binding]; other site 718254007427 active site 718254007428 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 718254007429 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 718254007430 Cupin domain; Region: Cupin_2; pfam07883 718254007431 D-galactonate transporter; Region: 2A0114; TIGR00893 718254007432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007433 putative substrate translocation pore; other site 718254007434 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 718254007435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254007436 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 718254007437 active site 718254007438 metal binding site [ion binding]; metal-binding site 718254007439 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 718254007440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718254007441 putative active site [active] 718254007442 putative metal binding site [ion binding]; other site 718254007443 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 718254007444 Transcriptional regulator [Transcription]; Region: IclR; COG1414 718254007445 Bacterial transcriptional regulator; Region: IclR; pfam01614 718254007446 short chain dehydrogenase; Provisional; Region: PRK12939 718254007447 classical (c) SDRs; Region: SDR_c; cd05233 718254007448 NAD(P) binding site [chemical binding]; other site 718254007449 active site 718254007450 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 718254007451 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 718254007452 [2Fe-2S] cluster binding site [ion binding]; other site 718254007453 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 718254007454 hydrophobic ligand binding site; other site 718254007455 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 718254007456 [2Fe-2S] cluster binding site [ion binding]; other site 718254007457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254007459 putative substrate translocation pore; other site 718254007460 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 718254007461 agmatinase; Region: agmatinase; TIGR01230 718254007462 oligomer interface [polypeptide binding]; other site 718254007463 putative active site [active] 718254007464 Mn binding site [ion binding]; other site 718254007465 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 718254007466 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 718254007467 dimer interface [polypeptide binding]; other site 718254007468 active site 718254007469 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718254007470 catalytic residues [active] 718254007471 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 718254007472 S-adenosylmethionine synthetase; Validated; Region: PRK05250 718254007473 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 718254007474 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 718254007475 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 718254007476 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 718254007477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007478 putative substrate translocation pore; other site 718254007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007480 hypothetical protein; Provisional; Region: PRK04860 718254007481 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 718254007482 DNA-specific endonuclease I; Provisional; Region: PRK15137 718254007483 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 718254007484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 718254007485 RNA methyltransferase, RsmE family; Region: TIGR00046 718254007486 glutathione synthetase; Provisional; Region: PRK05246 718254007487 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 718254007488 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 718254007489 hypothetical protein; Validated; Region: PRK00228 718254007490 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 718254007491 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 718254007492 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 718254007493 Walker A motif; other site 718254007494 ATP binding site [chemical binding]; other site 718254007495 Walker B motif; other site 718254007496 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 718254007497 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718254007498 catalytic residue [active] 718254007499 YGGT family; Region: YGGT; pfam02325 718254007500 YGGT family; Region: YGGT; pfam02325 718254007501 hypothetical protein; Validated; Region: PRK05090 718254007502 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 718254007503 active site 718254007504 dimerization interface [polypeptide binding]; other site 718254007505 HemN family oxidoreductase; Provisional; Region: PRK05660 718254007506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254007507 FeS/SAM binding site; other site 718254007508 HemN C-terminal domain; Region: HemN_C; pfam06969 718254007509 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 718254007510 putative active site [active] 718254007511 hypothetical protein; Provisional; Region: PRK10626 718254007512 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 718254007513 hypothetical protein; Provisional; Region: PRK11702 718254007514 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 718254007515 oxidative damage protection protein; Provisional; Region: PRK05408 718254007516 murein transglycosylase C; Provisional; Region: mltC; PRK11671 718254007517 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 718254007518 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718254007519 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718254007520 catalytic residue [active] 718254007521 nucleoside transporter; Region: 2A0110; TIGR00889 718254007522 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 718254007523 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 718254007524 Coenzyme A transferase; Region: CoA_trans; cl17247 718254007525 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 718254007526 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 718254007527 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 718254007528 putative active site [active] 718254007529 (T/H)XGH motif; other site 718254007530 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 718254007531 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 718254007532 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 718254007533 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 718254007534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718254007535 putative active site [active] 718254007536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254007537 ATP binding site [chemical binding]; other site 718254007538 Mg2+ binding site [ion binding]; other site 718254007539 G-X-G motif; other site 718254007540 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 718254007541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254007542 active site 718254007543 phosphorylation site [posttranslational modification] 718254007544 intermolecular recognition site; other site 718254007545 dimerization interface [polypeptide binding]; other site 718254007546 Transcriptional regulator; Region: CitT; pfam12431 718254007547 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 718254007548 ornithine decarboxylase; Provisional; Region: PRK13578 718254007549 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718254007550 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 718254007551 homodimer interface [polypeptide binding]; other site 718254007552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254007553 catalytic residue [active] 718254007554 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718254007555 Protein of unknown function (DUF554); Region: DUF554; pfam04474 718254007556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718254007557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254007558 dimer interface [polypeptide binding]; other site 718254007559 phosphorylation site [posttranslational modification] 718254007560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254007561 ATP binding site [chemical binding]; other site 718254007562 Mg2+ binding site [ion binding]; other site 718254007563 G-X-G motif; other site 718254007564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254007565 Response regulator receiver domain; Region: Response_reg; pfam00072 718254007566 active site 718254007567 phosphorylation site [posttranslational modification] 718254007568 intermolecular recognition site; other site 718254007569 dimerization interface [polypeptide binding]; other site 718254007570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 718254007571 DNA binding residues [nucleotide binding] 718254007572 dimerization interface [polypeptide binding]; other site 718254007573 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 718254007574 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 718254007575 putative active site [active] 718254007576 putative metal binding site [ion binding]; other site 718254007577 N-glycosyltransferase; Provisional; Region: PRK11204 718254007578 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 718254007579 DXD motif; other site 718254007580 PgaD-like protein; Region: PgaD; cl14676 718254007581 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 718254007582 CHAP domain; Region: CHAP; pfam05257 718254007583 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 718254007584 putative S-transferase; Provisional; Region: PRK11752 718254007585 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 718254007586 C-terminal domain interface [polypeptide binding]; other site 718254007587 GSH binding site (G-site) [chemical binding]; other site 718254007588 dimer interface [polypeptide binding]; other site 718254007589 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 718254007590 dimer interface [polypeptide binding]; other site 718254007591 N-terminal domain interface [polypeptide binding]; other site 718254007592 active site 718254007593 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 718254007594 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 718254007595 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254007596 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 718254007597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254007598 dimerization interface [polypeptide binding]; other site 718254007599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254007600 dimer interface [polypeptide binding]; other site 718254007601 putative CheW interface [polypeptide binding]; other site 718254007602 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254007603 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254007604 active site 718254007605 catalytic tetrad [active] 718254007606 hypothetical protein; Provisional; Region: PRK05208 718254007607 biopolymer transport protein ExbD; Provisional; Region: PRK11267 718254007608 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 718254007609 biopolymer transport protein ExbB; Provisional; Region: PRK10414 718254007610 cystathionine beta-lyase; Provisional; Region: PRK08114 718254007611 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 718254007612 homodimer interface [polypeptide binding]; other site 718254007613 substrate-cofactor binding pocket; other site 718254007614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254007615 catalytic residue [active] 718254007616 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718254007617 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 718254007618 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 718254007619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254007620 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718254007621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254007622 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254007623 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254007624 active site 718254007625 catalytic tetrad [active] 718254007626 hypothetical protein; Provisional; Region: PRK01254 718254007627 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 718254007628 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 718254007629 FtsI repressor; Provisional; Region: PRK10883 718254007630 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 718254007631 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 718254007632 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 718254007633 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718254007634 putative acyl-acceptor binding pocket; other site 718254007635 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 718254007636 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 718254007637 CAP-like domain; other site 718254007638 active site 718254007639 primary dimer interface [polypeptide binding]; other site 718254007640 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 718254007641 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 718254007642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254007643 active site 718254007644 phosphorylation site [posttranslational modification] 718254007645 intermolecular recognition site; other site 718254007646 dimerization interface [polypeptide binding]; other site 718254007647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254007648 DNA binding site [nucleotide binding] 718254007649 sensor protein QseC; Provisional; Region: PRK10337 718254007650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254007651 dimer interface [polypeptide binding]; other site 718254007652 phosphorylation site [posttranslational modification] 718254007653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254007654 ATP binding site [chemical binding]; other site 718254007655 Mg2+ binding site [ion binding]; other site 718254007656 G-X-G motif; other site 718254007657 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 718254007658 Uncharacterized conserved protein [Function unknown]; Region: COG1359 718254007659 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 718254007660 BON domain; Region: BON; pfam04972 718254007661 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718254007662 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 718254007663 galactoside permease; Reviewed; Region: lacY; PRK09528 718254007664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007665 putative substrate translocation pore; other site 718254007666 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 718254007667 Cupin domain; Region: Cupin_2; pfam07883 718254007668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254007669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718254007670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254007671 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 718254007672 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254007673 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254007674 putative active site [active] 718254007675 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 718254007676 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 718254007677 intersubunit interface [polypeptide binding]; other site 718254007678 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 718254007679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254007680 ABC-ATPase subunit interface; other site 718254007681 dimer interface [polypeptide binding]; other site 718254007682 putative PBP binding regions; other site 718254007683 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254007684 putative PBP binding regions; other site 718254007685 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 718254007686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254007687 N-terminal plug; other site 718254007688 ligand-binding site [chemical binding]; other site 718254007689 esterase YqiA; Provisional; Region: PRK11071 718254007690 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 718254007691 putative dehydrogenase; Provisional; Region: PRK11039 718254007692 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 718254007693 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718254007694 dimer interface [polypeptide binding]; other site 718254007695 ADP-ribose binding site [chemical binding]; other site 718254007696 active site 718254007697 nudix motif; other site 718254007698 metal binding site [ion binding]; metal-binding site 718254007699 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 718254007700 hypothetical protein; Provisional; Region: PRK11653 718254007701 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 718254007702 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 718254007703 putative active site [active] 718254007704 metal binding site [ion binding]; metal-binding site 718254007705 zinc transporter ZupT; Provisional; Region: PRK04201 718254007706 ZIP Zinc transporter; Region: Zip; pfam02535 718254007707 Fimbrial protein; Region: Fimbrial; cl01416 718254007708 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254007709 PapC N-terminal domain; Region: PapC_N; pfam13954 718254007710 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254007711 PapC C-terminal domain; Region: PapC_C; pfam13953 718254007712 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718254007713 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254007714 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254007715 Fimbrial protein; Region: Fimbrial; pfam00419 718254007716 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 718254007717 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 718254007718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 718254007719 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 718254007720 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 718254007721 putative ribose interaction site [chemical binding]; other site 718254007722 putative ADP binding site [chemical binding]; other site 718254007723 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 718254007724 active site 718254007725 nucleotide binding site [chemical binding]; other site 718254007726 HIGH motif; other site 718254007727 KMSKS motif; other site 718254007728 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 718254007729 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 718254007730 metal binding triad; other site 718254007731 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 718254007732 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 718254007733 metal binding triad; other site 718254007734 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 718254007735 SH3 domain-containing protein; Provisional; Region: PRK10884 718254007736 Bacterial SH3 domain homologues; Region: SH3b; smart00287 718254007737 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 718254007738 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 718254007739 homooctamer interface [polypeptide binding]; other site 718254007740 active site 718254007741 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 718254007742 benzoate transport; Region: 2A0115; TIGR00895 718254007743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007744 putative substrate translocation pore; other site 718254007745 UreD urease accessory protein; Region: UreD; pfam01774 718254007746 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 718254007747 alpha-gamma subunit interface [polypeptide binding]; other site 718254007748 beta-gamma subunit interface [polypeptide binding]; other site 718254007749 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 718254007750 gamma-beta subunit interface [polypeptide binding]; other site 718254007751 alpha-beta subunit interface [polypeptide binding]; other site 718254007752 urease subunit alpha; Reviewed; Region: ureC; PRK13207 718254007753 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 718254007754 subunit interactions [polypeptide binding]; other site 718254007755 active site 718254007756 flap region; other site 718254007757 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 718254007758 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 718254007759 dimer interface [polypeptide binding]; other site 718254007760 catalytic residues [active] 718254007761 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 718254007762 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 718254007763 UreF; Region: UreF; pfam01730 718254007764 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718254007765 UGMP family protein; Validated; Region: PRK09604 718254007766 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 718254007767 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 718254007768 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 718254007769 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 718254007770 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 718254007771 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 718254007772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718254007773 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718254007774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718254007775 DNA binding residues [nucleotide binding] 718254007776 Divergent AAA domain; Region: AAA_4; pfam04326 718254007777 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 718254007778 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 718254007779 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 718254007780 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 718254007781 HSP70 interaction site [polypeptide binding]; other site 718254007782 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 718254007783 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 718254007784 FAD binding pocket [chemical binding]; other site 718254007785 FAD binding motif [chemical binding]; other site 718254007786 phosphate binding motif [ion binding]; other site 718254007787 NAD binding pocket [chemical binding]; other site 718254007788 Predicted transcriptional regulators [Transcription]; Region: COG1695 718254007789 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 718254007790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718254007791 putative active site [active] 718254007792 PAS fold; Region: PAS_3; pfam08447 718254007793 heme pocket [chemical binding]; other site 718254007794 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 718254007795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254007796 dimer interface [polypeptide binding]; other site 718254007797 putative CheW interface [polypeptide binding]; other site 718254007798 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718254007799 Fimbrial protein; Region: Fimbrial; cl01416 718254007800 Fimbrial protein; Region: Fimbrial; cl01416 718254007801 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254007802 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254007803 Fimbrial protein; Region: Fimbrial; cl01416 718254007804 Fimbrial protein; Region: Fimbrial; cl01416 718254007805 Fimbrial protein; Region: Fimbrial; cl01416 718254007806 fimbrial chaperone BcfG; Provisional; Region: PRK15192 718254007807 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254007808 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254007809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254007810 sequence-specific DNA binding site [nucleotide binding]; other site 718254007811 salt bridge; other site 718254007812 Cupin domain; Region: Cupin_2; pfam07883 718254007813 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 718254007814 B3/4 domain; Region: B3_4; pfam03483 718254007815 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 718254007816 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 718254007817 ligand binding site [chemical binding]; other site 718254007818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254007819 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254007820 TM-ABC transporter signature motif; other site 718254007821 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254007822 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254007823 TM-ABC transporter signature motif; other site 718254007824 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 718254007825 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254007826 Walker A/P-loop; other site 718254007827 ATP binding site [chemical binding]; other site 718254007828 Q-loop/lid; other site 718254007829 ABC transporter signature motif; other site 718254007830 Walker B; other site 718254007831 D-loop; other site 718254007832 H-loop/switch region; other site 718254007833 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254007834 transcriptional regulator LsrR; Provisional; Region: PRK15418 718254007835 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 718254007836 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 718254007837 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 718254007838 putative N- and C-terminal domain interface [polypeptide binding]; other site 718254007839 putative active site [active] 718254007840 putative MgATP binding site [chemical binding]; other site 718254007841 catalytic site [active] 718254007842 metal binding site [ion binding]; metal-binding site 718254007843 putative carbohydrate binding site [chemical binding]; other site 718254007844 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 718254007845 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 718254007846 active site 718254007847 FMN binding site [chemical binding]; other site 718254007848 2,4-decadienoyl-CoA binding site; other site 718254007849 catalytic residue [active] 718254007850 4Fe-4S cluster binding site [ion binding]; other site 718254007851 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 718254007852 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 718254007853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254007854 S-adenosylmethionine binding site [chemical binding]; other site 718254007855 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 718254007856 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718254007857 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718254007858 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 718254007859 serine/threonine transporter SstT; Provisional; Region: PRK13628 718254007860 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718254007861 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 718254007862 galactarate dehydratase; Region: galactar-dH20; TIGR03248 718254007863 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 718254007864 Glucuronate isomerase; Region: UxaC; pfam02614 718254007865 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 718254007866 D-galactonate transporter; Region: 2A0114; TIGR00893 718254007867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254007868 putative substrate translocation pore; other site 718254007869 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 718254007870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254007871 DNA-binding site [nucleotide binding]; DNA binding site 718254007872 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718254007873 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718254007874 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 718254007875 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 718254007876 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 718254007877 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 718254007878 Predicted membrane protein [Function unknown]; Region: COG5393 718254007879 Predicted membrane protein [Function unknown]; Region: COG2259 718254007880 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 718254007881 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 718254007882 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 718254007883 putative dimer interface [polypeptide binding]; other site 718254007884 N-terminal domain interface [polypeptide binding]; other site 718254007885 putative substrate binding pocket (H-site) [chemical binding]; other site 718254007886 Predicted membrane protein [Function unknown]; Region: COG3152 718254007887 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 718254007888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254007889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254007890 dimerization interface [polypeptide binding]; other site 718254007891 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 718254007892 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718254007893 serine transporter; Region: stp; TIGR00814 718254007894 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 718254007895 Pyruvate formate lyase 1; Region: PFL1; cd01678 718254007896 coenzyme A binding site [chemical binding]; other site 718254007897 active site 718254007898 catalytic residues [active] 718254007899 glycine loop; other site 718254007900 propionate/acetate kinase; Provisional; Region: PRK12379 718254007901 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 718254007902 threonine/serine transporter TdcC; Provisional; Region: PRK13629 718254007903 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718254007904 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 718254007905 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 718254007906 tetramer interface [polypeptide binding]; other site 718254007907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254007908 catalytic residue [active] 718254007909 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 718254007910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254007911 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 718254007912 putative substrate binding pocket [chemical binding]; other site 718254007913 putative dimerization interface [polypeptide binding]; other site 718254007914 glycerate kinase I; Provisional; Region: PRK10342 718254007915 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 718254007916 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 718254007917 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 718254007918 galactarate dehydratase; Region: galactar-dH20; TIGR03248 718254007919 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 718254007920 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 718254007921 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 718254007922 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 718254007923 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254007924 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 718254007925 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 718254007926 active site 718254007927 phosphorylation site [posttranslational modification] 718254007928 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 718254007929 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 718254007930 dimer interface [polypeptide binding]; other site 718254007931 active site 718254007932 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 718254007933 putative active site [active] 718254007934 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 718254007935 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 718254007936 intersubunit interface [polypeptide binding]; other site 718254007937 active site 718254007938 zinc binding site [ion binding]; other site 718254007939 Na+ binding site [ion binding]; other site 718254007940 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 718254007941 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254007942 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254007943 active site turn [active] 718254007944 phosphorylation site [posttranslational modification] 718254007945 Melibiase; Region: Melibiase; pfam02065 718254007946 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 718254007947 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 718254007948 putative SAM binding site [chemical binding]; other site 718254007949 putative homodimer interface [polypeptide binding]; other site 718254007950 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 718254007951 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 718254007952 putative ligand binding site [chemical binding]; other site 718254007953 hypothetical protein; Reviewed; Region: PRK12497 718254007954 outer membrane lipoprotein; Provisional; Region: PRK11023 718254007955 BON domain; Region: BON; pfam04972 718254007956 BON domain; Region: BON; pfam04972 718254007957 intracellular protease, PfpI family; Region: PfpI; TIGR01382 718254007958 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 718254007959 proposed catalytic triad [active] 718254007960 conserved cys residue [active] 718254007961 hypothetical protein; Provisional; Region: PRK03467 718254007962 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 718254007963 GIY-YIG motif/motif A; other site 718254007964 putative active site [active] 718254007965 putative metal binding site [ion binding]; other site 718254007966 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 718254007967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254007968 Coenzyme A binding pocket [chemical binding]; other site 718254007969 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 718254007970 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 718254007971 Peptidase family U32; Region: Peptidase_U32; pfam01136 718254007972 putative protease; Provisional; Region: PRK15447 718254007973 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 718254007974 hypothetical protein; Provisional; Region: PRK10508 718254007975 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 718254007976 tryptophan permease; Provisional; Region: PRK10483 718254007977 aromatic amino acid transport protein; Region: araaP; TIGR00837 718254007978 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 718254007979 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718254007980 ATP binding site [chemical binding]; other site 718254007981 Mg++ binding site [ion binding]; other site 718254007982 motif III; other site 718254007983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254007984 nucleotide binding region [chemical binding]; other site 718254007985 ATP-binding site [chemical binding]; other site 718254007986 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 718254007987 putative RNA binding site [nucleotide binding]; other site 718254007988 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 718254007989 16S/18S rRNA binding site [nucleotide binding]; other site 718254007990 S13e-L30e interaction site [polypeptide binding]; other site 718254007991 25S rRNA binding site [nucleotide binding]; other site 718254007992 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 718254007993 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 718254007994 RNA binding site [nucleotide binding]; other site 718254007995 active site 718254007996 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 718254007997 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 718254007998 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 718254007999 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 718254008000 translation initiation factor IF-2; Region: IF-2; TIGR00487 718254008001 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 718254008002 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 718254008003 G1 box; other site 718254008004 putative GEF interaction site [polypeptide binding]; other site 718254008005 GTP/Mg2+ binding site [chemical binding]; other site 718254008006 Switch I region; other site 718254008007 G2 box; other site 718254008008 G3 box; other site 718254008009 Switch II region; other site 718254008010 G4 box; other site 718254008011 G5 box; other site 718254008012 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 718254008013 Translation-initiation factor 2; Region: IF-2; pfam11987 718254008014 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 718254008015 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 718254008016 NusA N-terminal domain; Region: NusA_N; pfam08529 718254008017 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 718254008018 RNA binding site [nucleotide binding]; other site 718254008019 homodimer interface [polypeptide binding]; other site 718254008020 NusA-like KH domain; Region: KH_5; pfam13184 718254008021 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 718254008022 G-X-X-G motif; other site 718254008023 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 718254008024 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 718254008025 ribosome maturation protein RimP; Reviewed; Region: PRK00092 718254008026 hypothetical protein; Provisional; Region: PRK14641 718254008027 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 718254008028 putative oligomer interface [polypeptide binding]; other site 718254008029 putative RNA binding site [nucleotide binding]; other site 718254008030 argininosuccinate synthase; Validated; Region: PRK05370 718254008031 argininosuccinate synthase; Provisional; Region: PRK13820 718254008032 Preprotein translocase SecG subunit; Region: SecG; pfam03840 718254008033 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 718254008034 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 718254008035 active site 718254008036 substrate binding site [chemical binding]; other site 718254008037 metal binding site [ion binding]; metal-binding site 718254008038 dihydropteroate synthase; Region: DHPS; TIGR01496 718254008039 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 718254008040 substrate binding pocket [chemical binding]; other site 718254008041 dimer interface [polypeptide binding]; other site 718254008042 inhibitor binding site; inhibition site 718254008043 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 718254008044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254008045 Walker A motif; other site 718254008046 ATP binding site [chemical binding]; other site 718254008047 Walker B motif; other site 718254008048 arginine finger; other site 718254008049 Peptidase family M41; Region: Peptidase_M41; pfam01434 718254008050 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 718254008051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254008052 S-adenosylmethionine binding site [chemical binding]; other site 718254008053 RNA-binding protein YhbY; Provisional; Region: PRK10343 718254008054 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 718254008055 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 718254008056 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 718254008057 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 718254008058 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 718254008059 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 718254008060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254008061 active site 718254008062 phosphorylation site [posttranslational modification] 718254008063 intermolecular recognition site; other site 718254008064 dimerization interface [polypeptide binding]; other site 718254008065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254008066 DNA binding site [nucleotide binding] 718254008067 sensor protein BasS/PmrB; Provisional; Region: PRK10755 718254008068 HAMP domain; Region: HAMP; pfam00672 718254008069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254008070 dimer interface [polypeptide binding]; other site 718254008071 phosphorylation site [posttranslational modification] 718254008072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254008073 ATP binding site [chemical binding]; other site 718254008074 Mg2+ binding site [ion binding]; other site 718254008075 G-X-G motif; other site 718254008076 GTPase CgtA; Reviewed; Region: obgE; PRK12298 718254008077 GTP1/OBG; Region: GTP1_OBG; pfam01018 718254008078 Obg GTPase; Region: Obg; cd01898 718254008079 G1 box; other site 718254008080 GTP/Mg2+ binding site [chemical binding]; other site 718254008081 Switch I region; other site 718254008082 G2 box; other site 718254008083 G3 box; other site 718254008084 Switch II region; other site 718254008085 G4 box; other site 718254008086 G5 box; other site 718254008087 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718254008088 EamA-like transporter family; Region: EamA; pfam00892 718254008089 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 718254008090 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 718254008091 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 718254008092 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 718254008093 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 718254008094 substrate binding pocket [chemical binding]; other site 718254008095 chain length determination region; other site 718254008096 substrate-Mg2+ binding site; other site 718254008097 catalytic residues [active] 718254008098 aspartate-rich region 1; other site 718254008099 active site lid residues [active] 718254008100 aspartate-rich region 2; other site 718254008101 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 718254008102 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 718254008103 hinge; other site 718254008104 active site 718254008105 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 718254008106 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 718254008107 anti sigma factor interaction site; other site 718254008108 regulatory phosphorylation site [posttranslational modification]; other site 718254008109 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 718254008110 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 718254008111 mce related protein; Region: MCE; pfam02470 718254008112 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 718254008113 conserved hypothetical integral membrane protein; Region: TIGR00056 718254008114 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 718254008115 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 718254008116 Walker A/P-loop; other site 718254008117 ATP binding site [chemical binding]; other site 718254008118 Q-loop/lid; other site 718254008119 ABC transporter signature motif; other site 718254008120 Walker B; other site 718254008121 D-loop; other site 718254008122 H-loop/switch region; other site 718254008123 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 718254008124 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 718254008125 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 718254008126 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 718254008127 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 718254008128 putative active site [active] 718254008129 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 718254008130 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 718254008131 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 718254008132 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 718254008133 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 718254008134 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 718254008135 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 718254008136 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 718254008137 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 718254008138 Walker A/P-loop; other site 718254008139 ATP binding site [chemical binding]; other site 718254008140 Q-loop/lid; other site 718254008141 ABC transporter signature motif; other site 718254008142 Walker B; other site 718254008143 D-loop; other site 718254008144 H-loop/switch region; other site 718254008145 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 718254008146 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 718254008147 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 718254008148 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 718254008149 30S subunit binding site; other site 718254008150 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254008151 active site 718254008152 phosphorylation site [posttranslational modification] 718254008153 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 718254008154 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718254008155 dimerization domain swap beta strand [polypeptide binding]; other site 718254008156 regulatory protein interface [polypeptide binding]; other site 718254008157 active site 718254008158 regulatory phosphorylation site [posttranslational modification]; other site 718254008159 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 718254008160 Transglycosylase; Region: Transgly; cl17702 718254008161 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 718254008162 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 718254008163 conserved cys residue [active] 718254008164 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 718254008165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718254008166 putative active site [active] 718254008167 heme pocket [chemical binding]; other site 718254008168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254008169 dimer interface [polypeptide binding]; other site 718254008170 phosphorylation site [posttranslational modification] 718254008171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254008172 ATP binding site [chemical binding]; other site 718254008173 Mg2+ binding site [ion binding]; other site 718254008174 G-X-G motif; other site 718254008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254008176 active site 718254008177 phosphorylation site [posttranslational modification] 718254008178 intermolecular recognition site; other site 718254008179 dimerization interface [polypeptide binding]; other site 718254008180 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718254008181 putative binding surface; other site 718254008182 active site 718254008183 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 718254008184 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 718254008185 multifunctional aminopeptidase A; Provisional; Region: PRK00913 718254008186 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 718254008187 interface (dimer of trimers) [polypeptide binding]; other site 718254008188 Substrate-binding/catalytic site; other site 718254008189 Zn-binding sites [ion binding]; other site 718254008190 DNA polymerase III subunit chi; Validated; Region: PRK05728 718254008191 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 718254008192 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 718254008193 HIGH motif; other site 718254008194 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718254008195 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 718254008196 active site 718254008197 KMSKS motif; other site 718254008198 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 718254008199 tRNA binding surface [nucleotide binding]; other site 718254008200 anticodon binding site; other site 718254008201 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 718254008202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 718254008203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254008204 Coenzyme A binding pocket [chemical binding]; other site 718254008205 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 718254008206 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 718254008207 putative NAD(P) binding site [chemical binding]; other site 718254008208 putative substrate binding site [chemical binding]; other site 718254008209 catalytic Zn binding site [ion binding]; other site 718254008210 structural Zn binding site [ion binding]; other site 718254008211 dimer interface [polypeptide binding]; other site 718254008212 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 718254008213 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 718254008214 DAK2 domain; Region: Dak2; pfam02734 718254008215 radical SAM protein, TIGR01212 family; Region: TIGR01212 718254008216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254008217 FeS/SAM binding site; other site 718254008218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718254008219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254008220 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 718254008221 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 718254008222 Na binding site [ion binding]; other site 718254008223 putative substrate binding site [chemical binding]; other site 718254008224 cytosine deaminase; Provisional; Region: PRK09230 718254008225 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 718254008226 active site 718254008227 Domain of unknown function (DUF386); Region: DUF386; cl01047 718254008228 N-acetylmannosamine kinase; Provisional; Region: PRK05082 718254008229 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718254008230 nucleotide binding site [chemical binding]; other site 718254008231 putative sialic acid transporter; Provisional; Region: PRK03893 718254008232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254008233 putative substrate translocation pore; other site 718254008234 N-acetylneuraminate lyase; Provisional; Region: PRK04147 718254008235 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 718254008236 inhibitor site; inhibition site 718254008237 active site 718254008238 dimer interface [polypeptide binding]; other site 718254008239 catalytic residue [active] 718254008240 transcriptional regulator NanR; Provisional; Region: PRK03837 718254008241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254008242 DNA-binding site [nucleotide binding]; DNA binding site 718254008243 FCD domain; Region: FCD; pfam07729 718254008244 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 718254008245 stringent starvation protein A; Provisional; Region: sspA; PRK09481 718254008246 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 718254008247 C-terminal domain interface [polypeptide binding]; other site 718254008248 putative GSH binding site (G-site) [chemical binding]; other site 718254008249 dimer interface [polypeptide binding]; other site 718254008250 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 718254008251 dimer interface [polypeptide binding]; other site 718254008252 N-terminal domain interface [polypeptide binding]; other site 718254008253 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 718254008254 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 718254008255 23S rRNA interface [nucleotide binding]; other site 718254008256 L3 interface [polypeptide binding]; other site 718254008257 Predicted ATPase [General function prediction only]; Region: COG1485 718254008258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 718254008259 hypothetical protein; Provisional; Region: PRK11677 718254008260 serine endoprotease; Provisional; Region: PRK10139 718254008261 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718254008262 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718254008263 protein binding site [polypeptide binding]; other site 718254008264 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718254008265 serine endoprotease; Provisional; Region: PRK10898 718254008266 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718254008267 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718254008268 malate dehydrogenase; Provisional; Region: PRK05086 718254008269 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 718254008270 NAD binding site [chemical binding]; other site 718254008271 dimerization interface [polypeptide binding]; other site 718254008272 Substrate binding site [chemical binding]; other site 718254008273 arginine repressor; Provisional; Region: PRK05066 718254008274 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 718254008275 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 718254008276 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718254008277 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 718254008278 RNAase interaction site [polypeptide binding]; other site 718254008279 succinic semialdehyde dehydrogenase; Region: PLN02278 718254008280 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 718254008281 tetramerization interface [polypeptide binding]; other site 718254008282 NAD(P) binding site [chemical binding]; other site 718254008283 catalytic residues [active] 718254008284 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 718254008285 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718254008286 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 718254008287 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254008288 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254008289 efflux system membrane protein; Provisional; Region: PRK11594 718254008290 transcriptional regulator; Provisional; Region: PRK10632 718254008291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254008292 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 718254008293 putative effector binding pocket; other site 718254008294 dimerization interface [polypeptide binding]; other site 718254008295 protease TldD; Provisional; Region: tldD; PRK10735 718254008296 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 718254008297 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 718254008298 homodimer interface [polypeptide binding]; other site 718254008299 Maf-like protein; Region: Maf; pfam02545 718254008300 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 718254008301 active site 718254008302 dimer interface [polypeptide binding]; other site 718254008303 rod shape-determining protein MreC; Region: mreC; TIGR00219 718254008304 rod shape-determining protein MreC; Region: MreC; pfam04085 718254008305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 718254008306 nucleotide binding site [chemical binding]; other site 718254008307 regulatory protein CsrD; Provisional; Region: PRK11059 718254008308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254008309 metal binding site [ion binding]; metal-binding site 718254008310 active site 718254008311 I-site; other site 718254008312 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254008313 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 718254008314 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 718254008315 NADP binding site [chemical binding]; other site 718254008316 dimer interface [polypeptide binding]; other site 718254008317 TMAO/DMSO reductase; Reviewed; Region: PRK05363 718254008318 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 718254008319 Moco binding site; other site 718254008320 metal coordination site [ion binding]; other site 718254008321 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 718254008322 Dehydroquinase class II; Region: DHquinase_II; pfam01220 718254008323 trimer interface [polypeptide binding]; other site 718254008324 active site 718254008325 dimer interface [polypeptide binding]; other site 718254008326 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 718254008327 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 718254008328 carboxyltransferase (CT) interaction site; other site 718254008329 biotinylation site [posttranslational modification]; other site 718254008330 ATP-grasp domain; Region: ATP-grasp_4; cl17255 718254008331 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 718254008332 hypothetical protein; Provisional; Region: PRK10633 718254008333 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 718254008334 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 718254008335 Na binding site [ion binding]; other site 718254008336 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 718254008337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718254008338 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 718254008339 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 718254008340 active site 718254008341 zinc binding site [ion binding]; other site 718254008342 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 718254008343 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718254008344 FMN binding site [chemical binding]; other site 718254008345 active site 718254008346 catalytic residues [active] 718254008347 substrate binding site [chemical binding]; other site 718254008348 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 718254008349 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 718254008350 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 718254008351 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 718254008352 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 718254008353 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 718254008354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254008355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254008356 metal binding site [ion binding]; metal-binding site 718254008357 active site 718254008358 I-site; other site 718254008359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254008360 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 718254008361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718254008362 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 718254008363 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 718254008364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254008365 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254008366 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 718254008367 Protein export membrane protein; Region: SecD_SecF; cl14618 718254008368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 718254008369 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 718254008370 TraX protein; Region: TraX; pfam05857 718254008371 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 718254008372 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 718254008373 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 718254008374 DNA binding site [nucleotide binding] 718254008375 Response regulator receiver domain; Region: Response_reg; pfam00072 718254008376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254008377 active site 718254008378 phosphorylation site [posttranslational modification] 718254008379 intermolecular recognition site; other site 718254008380 dimerization interface [polypeptide binding]; other site 718254008381 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 718254008382 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 718254008383 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 718254008384 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 718254008385 Multicopper oxidase; Region: Cu-oxidase; pfam00394 718254008386 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 718254008387 Peptidase family M23; Region: Peptidase_M23; pfam01551 718254008388 Protein of unknown function, DUF; Region: DUF411; cl01142 718254008389 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 718254008390 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 718254008391 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254008392 periplasmic copper-binding protein; Provisional; Region: PRK09838 718254008393 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 718254008394 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 718254008395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254008396 active site 718254008397 phosphorylation site [posttranslational modification] 718254008398 intermolecular recognition site; other site 718254008399 dimerization interface [polypeptide binding]; other site 718254008400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254008401 DNA binding site [nucleotide binding] 718254008402 sensor kinase CusS; Provisional; Region: PRK09835 718254008403 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254008404 dimerization interface [polypeptide binding]; other site 718254008405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254008406 dimer interface [polypeptide binding]; other site 718254008407 phosphorylation site [posttranslational modification] 718254008408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254008409 ATP binding site [chemical binding]; other site 718254008410 Mg2+ binding site [ion binding]; other site 718254008411 G-X-G motif; other site 718254008412 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 718254008413 Domain of unknown function DUF87; Region: DUF87; pfam01935 718254008414 HerA helicase [Replication, recombination, and repair]; Region: COG0433 718254008415 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 718254008416 active site 718254008417 NTP binding site [chemical binding]; other site 718254008418 metal binding triad [ion binding]; metal-binding site 718254008419 Phage integrase family; Region: Phage_integrase; pfam00589 718254008420 active site 718254008421 DNA binding site [nucleotide binding] 718254008422 Int/Topo IB signature motif; other site 718254008423 Initiator Replication protein; Region: Rep_3; cl17676 718254008424 plasmid-partitioning protein; Provisional; Region: PRK13698 718254008425 ParB-like nuclease domain; Region: ParB; smart00470 718254008426 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 718254008427 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 718254008428 active site 718254008429 DNA binding site [nucleotide binding] 718254008430 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 718254008431 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 718254008432 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718254008433 Catalytic site [active] 718254008434 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 718254008435 Mg binding site [ion binding]; other site 718254008436 nucleotide binding site [chemical binding]; other site 718254008437 putative protofilament interface [polypeptide binding]; other site 718254008438 putative methylase; Provisional; Region: PRK13699 718254008439 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 718254008440 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 718254008441 Antirestriction protein; Region: Antirestrict; pfam03230 718254008442 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 718254008443 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 718254008444 PsiA protein; Region: PsiA; pfam06952 718254008445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 718254008446 Helix-turn-helix domain; Region: HTH_28; pfam13518 718254008447 Helix-turn-helix domain; Region: HTH_28; pfam13518 718254008448 Integrase core domain; Region: rve; pfam00665 718254008449 Integrase core domain; Region: rve_2; pfam13333 718254008450 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 718254008451 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 718254008452 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 718254008453 ArsC family; Region: ArsC; pfam03960 718254008454 catalytic residues [active] 718254008455 Helix-turn-helix domain; Region: HTH_28; pfam13518 718254008456 Winged helix-turn helix; Region: HTH_29; pfam13551 718254008457 Homeodomain-like domain; Region: HTH_32; pfam13565 718254008458 Integrase core domain; Region: rve; pfam00665 718254008459 Integrase core domain; Region: rve_3; cl15866 718254008460 Uncharacterized conserved protein [Function unknown]; Region: COG2128 718254008461 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 718254008462 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 718254008463 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 718254008464 conserved cys residue [active] 718254008465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254008466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254008467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254008468 putative substrate translocation pore; other site 718254008469 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 718254008470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254008471 NAD(P) binding site [chemical binding]; other site 718254008472 active site 718254008473 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 718254008474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718254008475 NAD(P) binding site [chemical binding]; other site 718254008476 active site 718254008477 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 718254008478 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 718254008479 Domain of unknown function (DUF932); Region: DUF932; pfam06067 718254008480 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 718254008481 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718254008482 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718254008483 catalytic residue [active] 718254008484 TraM protein; Region: Tra_M; cl11621 718254008485 TraA; Region: TraA; cl11503 718254008486 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 718254008487 TraE protein; Region: TraE; pfam05309 718254008488 conjugal transfer protein TraK; Provisional; Region: PRK13736 718254008489 TraK protein; Region: TraK; pfam06586 718254008490 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 718254008491 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 718254008492 conjugal transfer protein TraV; Provisional; Region: PRK13733 718254008493 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 718254008494 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 718254008495 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 718254008496 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 718254008497 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 718254008498 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 718254008499 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 718254008500 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 718254008501 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 718254008502 F plasmid transfer operon protein; Region: TraF; pfam13728 718254008503 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 718254008504 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 718254008505 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 718254008506 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 718254008507 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 718254008508 F sex factor protein N terminal; Region: TraD_N; pfam12615 718254008509 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718254008510 Walker A motif; other site 718254008511 ATP binding site [chemical binding]; other site 718254008512 Walker B motif; other site 718254008513 TrwC relaxase; Region: TrwC; pfam08751 718254008514 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 718254008515 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 718254008516 AAA domain; Region: AAA_30; pfam13604 718254008517 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 718254008518 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 718254008519 catalytic residues [active] 718254008520 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 718254008521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254008522 putative substrate translocation pore; other site 718254008523 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718254008524 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718254008525 NAD(P) binding site [chemical binding]; other site 718254008526 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 718254008527 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718254008528 Walker A/P-loop; other site 718254008529 ATP binding site [chemical binding]; other site 718254008530 Q-loop/lid; other site 718254008531 ABC transporter signature motif; other site 718254008532 Walker B; other site 718254008533 D-loop; other site 718254008534 H-loop/switch region; other site 718254008535 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 718254008536 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254008537 ABC-ATPase subunit interface; other site 718254008538 dimer interface [polypeptide binding]; other site 718254008539 putative PBP binding regions; other site 718254008540 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718254008541 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254008542 dimer interface [polypeptide binding]; other site 718254008543 ABC-ATPase subunit interface; other site 718254008544 putative PBP binding regions; other site 718254008545 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 718254008546 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 718254008547 siderophore binding site; other site 718254008548 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 718254008549 Secretin and TonB N terminus short domain; Region: STN; smart00965 718254008550 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254008551 N-terminal plug; other site 718254008552 ligand-binding site [chemical binding]; other site 718254008553 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 718254008554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718254008555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718254008556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 718254008557 Integrase core domain; Region: rve; pfam00665 718254008558 Integrase core domain; Region: rve_3; cl15866 718254008559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 718254008560 Transposase; Region: HTH_Tnp_1; cl17663 718254008561 HTH-like domain; Region: HTH_21; pfam13276 718254008562 Integrase core domain; Region: rve; pfam00665 718254008563 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 718254008564 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 718254008565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254008566 putative substrate translocation pore; other site 718254008567 lipoprotein; Provisional; Region: PRK10759 718254008568 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 718254008569 CoA binding domain; Region: CoA_binding_2; pfam13380 718254008570 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 718254008571 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 718254008572 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 718254008573 Uncharacterized conserved protein [Function unknown]; Region: COG3148 718254008574 thioredoxin 2; Provisional; Region: PRK10996 718254008575 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 718254008576 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 718254008577 catalytic residues [active] 718254008578 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 718254008579 UGI interface [polypeptide binding]; other site 718254008580 active site 718254008581 catalytic site [active] 718254008582 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 718254008583 ligand binding site [chemical binding]; other site 718254008584 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 718254008585 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 718254008586 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718254008587 ATP binding site [chemical binding]; other site 718254008588 Mg++ binding site [ion binding]; other site 718254008589 motif III; other site 718254008590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254008591 nucleotide binding region [chemical binding]; other site 718254008592 ATP-binding site [chemical binding]; other site 718254008593 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 718254008594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254008595 S-adenosylmethionine binding site [chemical binding]; other site 718254008596 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 718254008597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718254008598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718254008599 DNA binding residues [nucleotide binding] 718254008600 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 718254008601 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 718254008602 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 718254008603 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 718254008604 anti-sigma E factor; Provisional; Region: rseB; PRK09455 718254008605 SoxR reducing system protein RseC; Provisional; Region: PRK10862 718254008606 GTP-binding protein LepA; Provisional; Region: PRK05433 718254008607 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 718254008608 G1 box; other site 718254008609 putative GEF interaction site [polypeptide binding]; other site 718254008610 GTP/Mg2+ binding site [chemical binding]; other site 718254008611 Switch I region; other site 718254008612 G2 box; other site 718254008613 G3 box; other site 718254008614 Switch II region; other site 718254008615 G4 box; other site 718254008616 G5 box; other site 718254008617 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 718254008618 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 718254008619 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 718254008620 signal peptidase I; Provisional; Region: PRK10861 718254008621 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718254008622 Catalytic site [active] 718254008623 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718254008624 ribonuclease III; Reviewed; Region: rnc; PRK00102 718254008625 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 718254008626 dimerization interface [polypeptide binding]; other site 718254008627 active site 718254008628 metal binding site [ion binding]; metal-binding site 718254008629 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 718254008630 dsRNA binding site [nucleotide binding]; other site 718254008631 GTPase Era; Reviewed; Region: era; PRK00089 718254008632 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 718254008633 G1 box; other site 718254008634 GTP/Mg2+ binding site [chemical binding]; other site 718254008635 Switch I region; other site 718254008636 G2 box; other site 718254008637 Switch II region; other site 718254008638 G3 box; other site 718254008639 G4 box; other site 718254008640 G5 box; other site 718254008641 KH domain; Region: KH_2; pfam07650 718254008642 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 718254008643 Recombination protein O N terminal; Region: RecO_N; pfam11967 718254008644 Recombination protein O C terminal; Region: RecO_C; pfam02565 718254008645 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 718254008646 active site 718254008647 hydrophilic channel; other site 718254008648 dimerization interface [polypeptide binding]; other site 718254008649 catalytic residues [active] 718254008650 active site lid [active] 718254008651 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 718254008652 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 718254008653 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254008654 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 718254008655 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254008656 putative active site [active] 718254008657 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 718254008658 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 718254008659 putative active site [active] 718254008660 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 718254008661 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254008662 active site turn [active] 718254008663 phosphorylation site [posttranslational modification] 718254008664 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254008665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718254008666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254008667 dimer interface [polypeptide binding]; other site 718254008668 phosphorylation site [posttranslational modification] 718254008669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254008670 ATP binding site [chemical binding]; other site 718254008671 Mg2+ binding site [ion binding]; other site 718254008672 G-X-G motif; other site 718254008673 hypothetical protein; Provisional; Region: PRK10722 718254008674 response regulator GlrR; Provisional; Region: PRK15115 718254008675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254008676 active site 718254008677 phosphorylation site [posttranslational modification] 718254008678 intermolecular recognition site; other site 718254008679 dimerization interface [polypeptide binding]; other site 718254008680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254008681 Walker A motif; other site 718254008682 ATP binding site [chemical binding]; other site 718254008683 Walker B motif; other site 718254008684 arginine finger; other site 718254008685 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 718254008686 Nitrogen regulatory protein P-II; Region: P-II; smart00938 718254008687 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 718254008688 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 718254008689 dimer interface [polypeptide binding]; other site 718254008690 active site 718254008691 glycine-pyridoxal phosphate binding site [chemical binding]; other site 718254008692 folate binding site [chemical binding]; other site 718254008693 Predicted membrane protein [Function unknown]; Region: COG2259 718254008694 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 718254008695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254008696 putative substrate translocation pore; other site 718254008697 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 718254008698 PRD domain; Region: PRD; pfam00874 718254008699 PRD domain; Region: PRD; pfam00874 718254008700 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 718254008701 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 718254008702 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 718254008703 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 718254008704 active site 718254008705 dimerization interface [polypeptide binding]; other site 718254008706 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 718254008707 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 718254008708 Transcriptional regulator; Region: Rrf2; cl17282 718254008709 Rrf2 family protein; Region: rrf2_super; TIGR00738 718254008710 cysteine desulfurase; Provisional; Region: PRK14012 718254008711 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 718254008712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718254008713 catalytic residue [active] 718254008714 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 718254008715 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 718254008716 trimerization site [polypeptide binding]; other site 718254008717 active site 718254008718 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 718254008719 co-chaperone HscB; Provisional; Region: hscB; PRK05014 718254008720 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718254008721 HSP70 interaction site [polypeptide binding]; other site 718254008722 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 718254008723 chaperone protein HscA; Provisional; Region: hscA; PRK05183 718254008724 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 718254008725 nucleotide binding site [chemical binding]; other site 718254008726 putative NEF/HSP70 interaction site [polypeptide binding]; other site 718254008727 SBD interface [polypeptide binding]; other site 718254008728 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 718254008729 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718254008730 catalytic loop [active] 718254008731 iron binding site [ion binding]; other site 718254008732 hypothetical protein; Provisional; Region: PRK10721 718254008733 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 718254008734 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 718254008735 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254008736 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254008737 putative active site [active] 718254008738 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 718254008739 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 718254008740 active site residue [active] 718254008741 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 718254008742 active site residue [active] 718254008743 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 718254008744 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 718254008745 NAD binding site [chemical binding]; other site 718254008746 sugar binding site [chemical binding]; other site 718254008747 divalent metal binding site [ion binding]; other site 718254008748 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 718254008749 dimer interface [polypeptide binding]; other site 718254008750 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254008751 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 718254008752 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 718254008753 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254008754 active site turn [active] 718254008755 phosphorylation site [posttranslational modification] 718254008756 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 718254008757 MG2 domain; Region: A2M_N; pfam01835 718254008758 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 718254008759 surface patch; other site 718254008760 thioester region; other site 718254008761 specificity defining residues; other site 718254008762 penicillin-binding protein 1C; Provisional; Region: PRK11240 718254008763 Transglycosylase; Region: Transgly; pfam00912 718254008764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 718254008765 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 718254008766 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 718254008767 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 718254008768 putative [Fe4-S4] binding site [ion binding]; other site 718254008769 putative molybdopterin cofactor binding site [chemical binding]; other site 718254008770 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 718254008771 putative molybdopterin cofactor binding site; other site 718254008772 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 718254008773 4Fe-4S binding domain; Region: Fer4; pfam00037 718254008774 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 718254008775 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 718254008776 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 718254008777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254008778 FeS/SAM binding site; other site 718254008779 cytoskeletal protein RodZ; Provisional; Region: PRK10856 718254008780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254008781 non-specific DNA binding site [nucleotide binding]; other site 718254008782 salt bridge; other site 718254008783 sequence-specific DNA binding site [nucleotide binding]; other site 718254008784 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 718254008785 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 718254008786 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 718254008787 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 718254008788 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 718254008789 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 718254008790 Trp docking motif [polypeptide binding]; other site 718254008791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254008792 putative substrate translocation pore; other site 718254008793 POT family; Region: PTR2; cl17359 718254008794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718254008795 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718254008796 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 718254008797 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 718254008798 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 718254008799 active site 718254008800 Zn binding site [ion binding]; other site 718254008801 GMP synthase; Reviewed; Region: guaA; PRK00074 718254008802 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 718254008803 AMP/PPi binding site [chemical binding]; other site 718254008804 candidate oxyanion hole; other site 718254008805 catalytic triad [active] 718254008806 potential glutamine specificity residues [chemical binding]; other site 718254008807 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 718254008808 ATP Binding subdomain [chemical binding]; other site 718254008809 Ligand Binding sites [chemical binding]; other site 718254008810 Dimerization subdomain; other site 718254008811 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 718254008812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254008813 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 718254008814 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254008815 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254008816 Predicted transcriptional regulator [Transcription]; Region: COG1959 718254008817 Transcriptional regulator; Region: Rrf2; pfam02082 718254008818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718254008819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 718254008820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254008821 dimer interface [polypeptide binding]; other site 718254008822 phosphorylation site [posttranslational modification] 718254008823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254008824 ATP binding site [chemical binding]; other site 718254008825 Mg2+ binding site [ion binding]; other site 718254008826 G-X-G motif; other site 718254008827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 718254008828 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 718254008829 MASE1; Region: MASE1; pfam05231 718254008830 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254008831 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 718254008832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254008833 exopolyphosphatase; Provisional; Region: PRK10854 718254008834 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 718254008835 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 718254008836 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 718254008837 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 718254008838 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 718254008839 domain interface [polypeptide binding]; other site 718254008840 active site 718254008841 catalytic site [active] 718254008842 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 718254008843 domain interface [polypeptide binding]; other site 718254008844 active site 718254008845 catalytic site [active] 718254008846 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 718254008847 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 718254008848 active site 718254008849 substrate binding site [chemical binding]; other site 718254008850 cosubstrate binding site; other site 718254008851 catalytic site [active] 718254008852 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 718254008853 beta-galactosidase; Region: BGL; TIGR03356 718254008854 uracil transporter; Provisional; Region: PRK10720 718254008855 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 718254008856 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 718254008857 interface (dimer of trimers) [polypeptide binding]; other site 718254008858 Substrate-binding/catalytic site; other site 718254008859 Zn-binding sites [ion binding]; other site 718254008860 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 718254008861 active site 718254008862 dimer interface [polypeptide binding]; other site 718254008863 catalytic nucleophile [active] 718254008864 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 718254008865 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 718254008866 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 718254008867 ArsC family; Region: ArsC; pfam03960 718254008868 catalytic residues [active] 718254008869 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 718254008870 Peptidase family M48; Region: Peptidase_M48; cl12018 718254008871 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 718254008872 Domain of unknown function DUF20; Region: UPF0118; pfam01594 718254008873 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 718254008874 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 718254008875 catalytic triad [active] 718254008876 dihydrodipicolinate synthase; Region: dapA; TIGR00674 718254008877 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 718254008878 dimer interface [polypeptide binding]; other site 718254008879 active site 718254008880 catalytic residue [active] 718254008881 lipoprotein; Provisional; Region: PRK11679 718254008882 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 718254008883 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 718254008884 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 718254008885 ATP binding site [chemical binding]; other site 718254008886 active site 718254008887 substrate binding site [chemical binding]; other site 718254008888 Predicted metalloprotease [General function prediction only]; Region: COG2321 718254008889 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 718254008890 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 718254008891 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 718254008892 Helicase; Region: Helicase_RecD; pfam05127 718254008893 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 718254008894 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 718254008895 putative hydrolase; Provisional; Region: PRK11460 718254008896 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 718254008897 hypothetical protein; Provisional; Region: PRK13664 718254008898 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 718254008899 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 718254008900 metal binding site [ion binding]; metal-binding site 718254008901 dimer interface [polypeptide binding]; other site 718254008902 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 718254008903 ArsC family; Region: ArsC; pfam03960 718254008904 putative catalytic residues [active] 718254008905 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 718254008906 Protein export membrane protein; Region: SecD_SecF; cl14618 718254008907 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 718254008908 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 718254008909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254008910 dimerization interface [polypeptide binding]; other site 718254008911 Histidine kinase; Region: HisKA_3; pfam07730 718254008912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254008913 ATP binding site [chemical binding]; other site 718254008914 Mg2+ binding site [ion binding]; other site 718254008915 G-X-G motif; other site 718254008916 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 718254008917 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718254008918 dimer interface [polypeptide binding]; other site 718254008919 ADP-ribose binding site [chemical binding]; other site 718254008920 active site 718254008921 nudix motif; other site 718254008922 metal binding site [ion binding]; metal-binding site 718254008923 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 718254008924 alpha-glucosidase; Provisional; Region: PRK10137 718254008925 Protein of unknown function, DUF608; Region: DUF608; pfam04685 718254008926 Trehalase; Region: Trehalase; cl17346 718254008927 inner membrane transporter YjeM; Provisional; Region: PRK15238 718254008928 Domain of unknown function (DUF386); Region: DUF386; cl01047 718254008929 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 718254008930 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 718254008931 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 718254008932 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 718254008933 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 718254008934 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 718254008935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254008936 DNA binding site [nucleotide binding] 718254008937 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 718254008938 putative dimerization interface [polypeptide binding]; other site 718254008939 putative ligand binding site [chemical binding]; other site 718254008940 transketolase; Reviewed; Region: PRK12753 718254008941 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 718254008942 TPP-binding site [chemical binding]; other site 718254008943 dimer interface [polypeptide binding]; other site 718254008944 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718254008945 PYR/PP interface [polypeptide binding]; other site 718254008946 dimer interface [polypeptide binding]; other site 718254008947 TPP binding site [chemical binding]; other site 718254008948 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718254008949 transaldolase-like protein; Provisional; Region: PTZ00411 718254008950 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 718254008951 active site 718254008952 dimer interface [polypeptide binding]; other site 718254008953 catalytic residue [active] 718254008954 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 718254008955 Malic enzyme, N-terminal domain; Region: malic; pfam00390 718254008956 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 718254008957 putative NAD(P) binding site [chemical binding]; other site 718254008958 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 718254008959 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 718254008960 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718254008961 active site 718254008962 metal binding site [ion binding]; metal-binding site 718254008963 putative acetyltransferase; Provisional; Region: PRK03624 718254008964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254008965 Coenzyme A binding pocket [chemical binding]; other site 718254008966 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 718254008967 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 718254008968 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 718254008969 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 718254008970 thiosulfate transporter subunit; Provisional; Region: PRK10852 718254008971 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718254008972 sulfate transport protein; Provisional; Region: cysT; CHL00187 718254008973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254008974 dimer interface [polypeptide binding]; other site 718254008975 conserved gate region; other site 718254008976 putative PBP binding loops; other site 718254008977 ABC-ATPase subunit interface; other site 718254008978 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 718254008979 dimer interface [polypeptide binding]; other site 718254008980 pyridoxamine kinase; Validated; Region: PRK05756 718254008981 pyridoxal binding site [chemical binding]; other site 718254008982 ATP binding site [chemical binding]; other site 718254008983 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 718254008984 HPr interaction site; other site 718254008985 glycerol kinase (GK) interaction site [polypeptide binding]; other site 718254008986 active site 718254008987 phosphorylation site [posttranslational modification] 718254008988 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 718254008989 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 718254008990 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 718254008991 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 718254008992 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718254008993 dimerization domain swap beta strand [polypeptide binding]; other site 718254008994 regulatory protein interface [polypeptide binding]; other site 718254008995 active site 718254008996 regulatory phosphorylation site [posttranslational modification]; other site 718254008997 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 718254008998 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 718254008999 dimer interface [polypeptide binding]; other site 718254009000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254009001 catalytic residue [active] 718254009002 putative sulfate transport protein CysZ; Validated; Region: PRK04949 718254009003 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 718254009004 cell division protein ZipA; Provisional; Region: PRK03427 718254009005 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 718254009006 FtsZ protein binding site [polypeptide binding]; other site 718254009007 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 718254009008 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 718254009009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254009010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254009011 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 718254009012 putative dimerization interface [polypeptide binding]; other site 718254009013 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 718254009014 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 718254009015 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718254009016 active site 718254009017 HIGH motif; other site 718254009018 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718254009019 active site 718254009020 KMSKS motif; other site 718254009021 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 718254009022 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 718254009023 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 718254009024 Nucleoside recognition; Region: Gate; pfam07670 718254009025 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 718254009026 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718254009027 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718254009028 active site 718254009029 catalytic tetrad [active] 718254009030 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 718254009031 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 718254009032 dimer interface [polypeptide binding]; other site 718254009033 PYR/PP interface [polypeptide binding]; other site 718254009034 TPP binding site [chemical binding]; other site 718254009035 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718254009036 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 718254009037 TPP-binding site [chemical binding]; other site 718254009038 dimer interface [polypeptide binding]; other site 718254009039 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 718254009040 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 718254009041 Cl- selectivity filter; other site 718254009042 Cl- binding residues [ion binding]; other site 718254009043 pore gating glutamate residue; other site 718254009044 glucokinase; Provisional; Region: glk; PRK00292 718254009045 glucokinase, proteobacterial type; Region: glk; TIGR00749 718254009046 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 718254009047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254009048 active site 718254009049 phosphorylation site [posttranslational modification] 718254009050 intermolecular recognition site; other site 718254009051 dimerization interface [polypeptide binding]; other site 718254009052 LytTr DNA-binding domain; Region: LytTR; pfam04397 718254009053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718254009054 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 718254009055 heme-binding site [chemical binding]; other site 718254009056 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718254009057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718254009058 metal binding site [ion binding]; metal-binding site 718254009059 active site 718254009060 I-site; other site 718254009061 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 718254009062 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 718254009063 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 718254009064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 718254009065 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 718254009066 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 718254009067 dimer interface [polypeptide binding]; other site 718254009068 active site 718254009069 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 718254009070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 718254009071 substrate binding site [chemical binding]; other site 718254009072 oxyanion hole (OAH) forming residues; other site 718254009073 trimer interface [polypeptide binding]; other site 718254009074 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 718254009075 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 718254009076 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718254009077 catalytic core [active] 718254009078 hypothetical protein; Provisional; Region: PRK04946 718254009079 Smr domain; Region: Smr; pfam01713 718254009080 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 718254009081 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 718254009082 Tetramer interface [polypeptide binding]; other site 718254009083 active site 718254009084 FMN-binding site [chemical binding]; other site 718254009085 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 718254009086 hypothetical protein; Provisional; Region: PRK10621 718254009087 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 718254009088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 718254009089 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 718254009090 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718254009091 dimer interface [polypeptide binding]; other site 718254009092 active site 718254009093 putative transporter; Provisional; Region: PRK12382 718254009094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009095 putative substrate translocation pore; other site 718254009096 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 718254009097 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 718254009098 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718254009099 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 718254009100 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 718254009101 dimerization interface 3.5A [polypeptide binding]; other site 718254009102 active site 718254009103 hypothetical protein; Provisional; Region: PRK10847 718254009104 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718254009105 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 718254009106 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 718254009107 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 718254009108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718254009109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718254009110 colicin V production protein; Provisional; Region: PRK10845 718254009111 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 718254009112 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 718254009113 Flavoprotein; Region: Flavoprotein; pfam02441 718254009114 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 718254009115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254009116 substrate binding pocket [chemical binding]; other site 718254009117 membrane-bound complex binding site; other site 718254009118 hinge residues; other site 718254009119 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 718254009120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718254009121 substrate binding pocket [chemical binding]; other site 718254009122 membrane-bound complex binding site; other site 718254009123 hinge residues; other site 718254009124 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718254009125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254009126 dimer interface [polypeptide binding]; other site 718254009127 conserved gate region; other site 718254009128 putative PBP binding loops; other site 718254009129 ABC-ATPase subunit interface; other site 718254009130 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 718254009131 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718254009132 Walker A/P-loop; other site 718254009133 ATP binding site [chemical binding]; other site 718254009134 Q-loop/lid; other site 718254009135 ABC transporter signature motif; other site 718254009136 Walker B; other site 718254009137 D-loop; other site 718254009138 H-loop/switch region; other site 718254009139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 718254009140 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718254009141 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 718254009142 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 718254009143 putative NAD(P) binding site [chemical binding]; other site 718254009144 putative active site [active] 718254009145 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 718254009146 homooctamer interface [polypeptide binding]; other site 718254009147 active site 718254009148 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 718254009149 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 718254009150 C-terminal domain interface [polypeptide binding]; other site 718254009151 GSH binding site (G-site) [chemical binding]; other site 718254009152 dimer interface [polypeptide binding]; other site 718254009153 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 718254009154 N-terminal domain interface [polypeptide binding]; other site 718254009155 putative dimer interface [polypeptide binding]; other site 718254009156 active site 718254009157 glutathione S-transferase; Provisional; Region: PRK15113 718254009158 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 718254009159 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 718254009160 N-terminal domain interface [polypeptide binding]; other site 718254009161 putative dimer interface [polypeptide binding]; other site 718254009162 putative substrate binding pocket (H-site) [chemical binding]; other site 718254009163 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 718254009164 active site 718254009165 metal binding site [ion binding]; metal-binding site 718254009166 homotetramer interface [polypeptide binding]; other site 718254009167 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 718254009168 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 718254009169 nudix motif; other site 718254009170 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254009171 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 718254009172 putative ligand binding site [chemical binding]; other site 718254009173 putative dimerization interface [polypeptide binding]; other site 718254009174 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 718254009175 transketolase; Reviewed; Region: PRK05899 718254009176 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 718254009177 TPP-binding site [chemical binding]; other site 718254009178 dimer interface [polypeptide binding]; other site 718254009179 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 718254009180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718254009181 PYR/PP interface [polypeptide binding]; other site 718254009182 dimer interface [polypeptide binding]; other site 718254009183 TPP binding site [chemical binding]; other site 718254009184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718254009185 phosphate acetyltransferase; Reviewed; Region: PRK05632 718254009186 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718254009187 DRTGG domain; Region: DRTGG; pfam07085 718254009188 phosphate acetyltransferase; Region: pta; TIGR00651 718254009189 propionate/acetate kinase; Provisional; Region: PRK12379 718254009190 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 718254009191 hypothetical protein; Provisional; Region: PRK01816 718254009192 hypothetical protein; Validated; Region: PRK05445 718254009193 5'-nucleotidase; Provisional; Region: PRK03826 718254009194 aminotransferase AlaT; Validated; Region: PRK09265 718254009195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254009196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254009197 homodimer interface [polypeptide binding]; other site 718254009198 catalytic residue [active] 718254009199 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 718254009200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254009201 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 718254009202 putative dimerization interface [polypeptide binding]; other site 718254009203 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 718254009204 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 718254009205 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 718254009206 NADH dehydrogenase subunit D; Validated; Region: PRK06075 718254009207 NADH dehydrogenase subunit E; Validated; Region: PRK07539 718254009208 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 718254009209 putative dimer interface [polypeptide binding]; other site 718254009210 [2Fe-2S] cluster binding site [ion binding]; other site 718254009211 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 718254009212 SLBB domain; Region: SLBB; pfam10531 718254009213 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 718254009214 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 718254009215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718254009216 catalytic loop [active] 718254009217 iron binding site [ion binding]; other site 718254009218 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 718254009219 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 718254009220 [4Fe-4S] binding site [ion binding]; other site 718254009221 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 718254009222 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 718254009223 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 718254009224 4Fe-4S binding domain; Region: Fer4; pfam00037 718254009225 4Fe-4S binding domain; Region: Fer4; pfam00037 718254009226 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 718254009227 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 718254009228 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 718254009229 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 718254009230 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718254009231 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 718254009232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718254009233 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 718254009234 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718254009235 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 718254009236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254009237 Response regulator receiver domain; Region: Response_reg; pfam00072 718254009238 active site 718254009239 phosphorylation site [posttranslational modification] 718254009240 intermolecular recognition site; other site 718254009241 dimerization interface [polypeptide binding]; other site 718254009242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 718254009243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254009244 Coenzyme A binding pocket [chemical binding]; other site 718254009245 hypothetical protein; Provisional; Region: PRK10404 718254009246 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 718254009247 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 718254009248 dimer interface [polypeptide binding]; other site 718254009249 tetramer interface [polypeptide binding]; other site 718254009250 PYR/PP interface [polypeptide binding]; other site 718254009251 TPP binding site [chemical binding]; other site 718254009252 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 718254009253 TPP-binding site; other site 718254009254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 718254009255 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 718254009256 substrate binding site [chemical binding]; other site 718254009257 oxyanion hole (OAH) forming residues; other site 718254009258 trimer interface [polypeptide binding]; other site 718254009259 O-succinylbenzoate synthase; Provisional; Region: PRK05105 718254009260 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 718254009261 active site 718254009262 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 718254009263 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 718254009264 acyl-activating enzyme (AAE) consensus motif; other site 718254009265 putative AMP binding site [chemical binding]; other site 718254009266 putative active site [active] 718254009267 putative CoA binding site [chemical binding]; other site 718254009268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 718254009269 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 718254009270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 718254009271 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 718254009272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254009273 active site 718254009274 phosphorylation site [posttranslational modification] 718254009275 intermolecular recognition site; other site 718254009276 dimerization interface [polypeptide binding]; other site 718254009277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254009278 DNA binding site [nucleotide binding] 718254009279 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 718254009280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718254009281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254009282 dimer interface [polypeptide binding]; other site 718254009283 phosphorylation site [posttranslational modification] 718254009284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254009285 ATP binding site [chemical binding]; other site 718254009286 Mg2+ binding site [ion binding]; other site 718254009287 G-X-G motif; other site 718254009288 YfaZ precursor; Region: YfaZ; pfam07437 718254009289 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 718254009290 hypothetical protein; Provisional; Region: PRK03673 718254009291 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 718254009292 putative MPT binding site; other site 718254009293 Competence-damaged protein; Region: CinA; cl00666 718254009294 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 718254009295 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718254009296 Cysteine-rich domain; Region: CCG; pfam02754 718254009297 Cysteine-rich domain; Region: CCG; pfam02754 718254009298 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 718254009299 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 718254009300 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 718254009301 hydroxyglutarate oxidase; Provisional; Region: PRK11728 718254009302 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 718254009303 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 718254009304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009305 putative substrate translocation pore; other site 718254009306 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 718254009307 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 718254009308 active site 718254009309 catalytic site [active] 718254009310 metal binding site [ion binding]; metal-binding site 718254009311 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 718254009312 dimer interface [polypeptide binding]; other site 718254009313 putative radical transfer pathway; other site 718254009314 diiron center [ion binding]; other site 718254009315 tyrosyl radical; other site 718254009316 DNA gyrase subunit A; Validated; Region: PRK05560 718254009317 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 718254009318 CAP-like domain; other site 718254009319 active site 718254009320 primary dimer interface [polypeptide binding]; other site 718254009321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718254009322 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718254009323 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718254009324 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718254009325 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718254009326 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718254009327 transcriptional regulator RcsB; Provisional; Region: PRK10840 718254009328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254009329 active site 718254009330 phosphorylation site [posttranslational modification] 718254009331 intermolecular recognition site; other site 718254009332 dimerization interface [polypeptide binding]; other site 718254009333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254009334 DNA binding residues [nucleotide binding] 718254009335 dimerization interface [polypeptide binding]; other site 718254009336 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 718254009337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254009338 ATP binding site [chemical binding]; other site 718254009339 Mg2+ binding site [ion binding]; other site 718254009340 G-X-G motif; other site 718254009341 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718254009342 putative binding surface; other site 718254009343 active site 718254009344 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 718254009345 ApbE family; Region: ApbE; pfam02424 718254009346 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 718254009347 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 718254009348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254009349 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 718254009350 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 718254009351 DNA binding site [nucleotide binding] 718254009352 active site 718254009353 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 718254009354 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 718254009355 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 718254009356 Walker A/P-loop; other site 718254009357 ATP binding site [chemical binding]; other site 718254009358 Q-loop/lid; other site 718254009359 ABC transporter signature motif; other site 718254009360 Walker B; other site 718254009361 D-loop; other site 718254009362 H-loop/switch region; other site 718254009363 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 718254009364 MgtE intracellular N domain; Region: MgtE_N; smart00924 718254009365 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 718254009366 Divalent cation transporter; Region: MgtE; cl00786 718254009367 malate:quinone oxidoreductase; Validated; Region: PRK05257 718254009368 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 718254009369 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 718254009370 secondary substrate binding site; other site 718254009371 primary substrate binding site; other site 718254009372 inhibition loop; other site 718254009373 dimerization interface [polypeptide binding]; other site 718254009374 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 718254009375 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 718254009376 hypothetical protein; Provisional; Region: PRK13689 718254009377 Nucleoid-associated protein [General function prediction only]; Region: COG3081 718254009378 nucleoid-associated protein NdpA; Validated; Region: PRK00378 718254009379 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 718254009380 5S rRNA interface [nucleotide binding]; other site 718254009381 CTC domain interface [polypeptide binding]; other site 718254009382 L16 interface [polypeptide binding]; other site 718254009383 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 718254009384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718254009385 ATP binding site [chemical binding]; other site 718254009386 putative Mg++ binding site [ion binding]; other site 718254009387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254009388 nucleotide binding region [chemical binding]; other site 718254009389 ATP-binding site [chemical binding]; other site 718254009390 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 718254009391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718254009392 RNA binding surface [nucleotide binding]; other site 718254009393 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 718254009394 active site 718254009395 uracil binding [chemical binding]; other site 718254009396 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 718254009397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254009398 Walker A/P-loop; other site 718254009399 ATP binding site [chemical binding]; other site 718254009400 Q-loop/lid; other site 718254009401 ABC transporter signature motif; other site 718254009402 Walker B; other site 718254009403 D-loop; other site 718254009404 H-loop/switch region; other site 718254009405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718254009406 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254009407 Walker A/P-loop; other site 718254009408 ATP binding site [chemical binding]; other site 718254009409 Q-loop/lid; other site 718254009410 ABC transporter signature motif; other site 718254009411 Walker B; other site 718254009412 D-loop; other site 718254009413 H-loop/switch region; other site 718254009414 microcin C ABC transporter permease; Provisional; Region: PRK15021 718254009415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254009416 dimer interface [polypeptide binding]; other site 718254009417 conserved gate region; other site 718254009418 ABC-ATPase subunit interface; other site 718254009419 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 718254009420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254009421 dimer interface [polypeptide binding]; other site 718254009422 conserved gate region; other site 718254009423 putative PBP binding loops; other site 718254009424 ABC-ATPase subunit interface; other site 718254009425 phage resistance protein; Provisional; Region: PRK10551 718254009426 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 718254009427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718254009428 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 718254009429 NlpC/P60 family; Region: NLPC_P60; pfam00877 718254009430 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 718254009431 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 718254009432 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 718254009433 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 718254009434 mannonate dehydratase; Provisional; Region: PRK03906 718254009435 mannonate dehydratase; Region: uxuA; TIGR00695 718254009436 sugar efflux transporter B; Provisional; Region: PRK15011 718254009437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009438 putative substrate translocation pore; other site 718254009439 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 718254009440 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254009441 active site 718254009442 phosphorylation site [posttranslational modification] 718254009443 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718254009444 dimerization domain swap beta strand [polypeptide binding]; other site 718254009445 regulatory protein interface [polypeptide binding]; other site 718254009446 active site 718254009447 regulatory phosphorylation site [posttranslational modification]; other site 718254009448 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 718254009449 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 718254009450 putative substrate binding site [chemical binding]; other site 718254009451 putative ATP binding site [chemical binding]; other site 718254009452 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 718254009453 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 718254009454 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 718254009455 active site 718254009456 P-loop; other site 718254009457 phosphorylation site [posttranslational modification] 718254009458 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 718254009459 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 718254009460 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 718254009461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254009462 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 718254009463 putative dimerization interface [polypeptide binding]; other site 718254009464 lysine transporter; Provisional; Region: PRK10836 718254009465 putative outer membrane receptor; Provisional; Region: PRK13513 718254009466 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254009467 N-terminal plug; other site 718254009468 ligand-binding site [chemical binding]; other site 718254009469 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 718254009470 S-formylglutathione hydrolase; Region: PLN02442 718254009471 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 718254009472 GTP cyclohydrolase I; Provisional; Region: PLN03044 718254009473 active site 718254009474 Predicted membrane protein [Function unknown]; Region: COG2311 718254009475 hypothetical protein; Provisional; Region: PRK10835 718254009476 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 718254009477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254009478 DNA binding site [nucleotide binding] 718254009479 domain linker motif; other site 718254009480 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 718254009481 dimerization interface (closed form) [polypeptide binding]; other site 718254009482 ligand binding site [chemical binding]; other site 718254009483 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 718254009484 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 718254009485 ligand binding site [chemical binding]; other site 718254009486 calcium binding site [ion binding]; other site 718254009487 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 718254009488 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254009489 Walker A/P-loop; other site 718254009490 ATP binding site [chemical binding]; other site 718254009491 Q-loop/lid; other site 718254009492 ABC transporter signature motif; other site 718254009493 Walker B; other site 718254009494 D-loop; other site 718254009495 H-loop/switch region; other site 718254009496 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254009497 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254009498 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254009499 TM-ABC transporter signature motif; other site 718254009500 hypothetical protein; Provisional; Region: PRK10711 718254009501 hypothetical protein; Provisional; Region: PRK01821 718254009502 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 718254009503 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718254009504 FMN binding site [chemical binding]; other site 718254009505 active site 718254009506 catalytic residues [active] 718254009507 substrate binding site [chemical binding]; other site 718254009508 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 718254009509 Outer membrane efflux protein; Region: OEP; pfam02321 718254009510 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718254009511 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718254009512 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 718254009513 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 718254009514 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 718254009515 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 718254009516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254009517 Coenzyme A binding pocket [chemical binding]; other site 718254009518 D-lactate dehydrogenase; Provisional; Region: PRK11183 718254009519 FAD binding domain; Region: FAD_binding_4; pfam01565 718254009520 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 718254009521 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 718254009522 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 718254009523 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 718254009524 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 718254009525 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 718254009526 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 718254009527 Walker A/P-loop; other site 718254009528 ATP binding site [chemical binding]; other site 718254009529 Q-loop/lid; other site 718254009530 ABC transporter signature motif; other site 718254009531 Walker B; other site 718254009532 D-loop; other site 718254009533 H-loop/switch region; other site 718254009534 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 718254009535 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 718254009536 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 718254009537 GAF domain; Region: GAF; pfam01590 718254009538 Histidine kinase; Region: His_kinase; pfam06580 718254009539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254009540 ATP binding site [chemical binding]; other site 718254009541 Mg2+ binding site [ion binding]; other site 718254009542 G-X-G motif; other site 718254009543 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 718254009544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254009545 active site 718254009546 phosphorylation site [posttranslational modification] 718254009547 intermolecular recognition site; other site 718254009548 dimerization interface [polypeptide binding]; other site 718254009549 LytTr DNA-binding domain; Region: LytTR; pfam04397 718254009550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 718254009551 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 718254009552 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 718254009553 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 718254009554 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 718254009555 active site 718254009556 HIGH motif; other site 718254009557 KMSKS motif; other site 718254009558 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 718254009559 tRNA binding surface [nucleotide binding]; other site 718254009560 anticodon binding site; other site 718254009561 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 718254009562 dimer interface [polypeptide binding]; other site 718254009563 putative tRNA-binding site [nucleotide binding]; other site 718254009564 antiporter inner membrane protein; Provisional; Region: PRK11670 718254009565 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 718254009566 Walker A motif; other site 718254009567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 718254009568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254009569 Coenzyme A binding pocket [chemical binding]; other site 718254009570 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 718254009571 polysaccharide export protein Wza; Provisional; Region: PRK15078 718254009572 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 718254009573 SLBB domain; Region: SLBB; pfam10531 718254009574 Low molecular weight phosphatase family; Region: LMWPc; cd00115 718254009575 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 718254009576 active site 718254009577 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 718254009578 Chain length determinant protein; Region: Wzz; pfam02706 718254009579 Chain length determinant protein; Region: Wzz; cl15801 718254009580 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 718254009581 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 718254009582 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 718254009583 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718254009584 inhibitor-cofactor binding pocket; inhibition site 718254009585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254009586 catalytic residue [active] 718254009587 YadA-like C-terminal region; Region: YadA; pfam03895 718254009588 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 718254009589 substrate binding site [chemical binding]; other site 718254009590 multimerization interface [polypeptide binding]; other site 718254009591 ATP binding site [chemical binding]; other site 718254009592 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 718254009593 nucleoside transporter; Region: 2A0110; TIGR00889 718254009594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009595 putative substrate translocation pore; other site 718254009596 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 718254009597 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 718254009598 putative active site; other site 718254009599 catalytic residue [active] 718254009600 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 718254009601 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 718254009602 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 718254009603 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 718254009604 N- and C-terminal domain interface [polypeptide binding]; other site 718254009605 D-xylulose kinase; Region: XylB; TIGR01312 718254009606 active site 718254009607 MgATP binding site [chemical binding]; other site 718254009608 catalytic site [active] 718254009609 metal binding site [ion binding]; metal-binding site 718254009610 xylulose binding site [chemical binding]; other site 718254009611 homodimer interface [polypeptide binding]; other site 718254009612 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 718254009613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254009614 motif II; other site 718254009615 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 718254009616 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 718254009617 putative active site pocket [active] 718254009618 metal binding site [ion binding]; metal-binding site 718254009619 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718254009620 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 718254009621 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 718254009622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254009623 dimer interface [polypeptide binding]; other site 718254009624 conserved gate region; other site 718254009625 ABC-ATPase subunit interface; other site 718254009626 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 718254009627 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718254009628 Walker A/P-loop; other site 718254009629 ATP binding site [chemical binding]; other site 718254009630 Q-loop/lid; other site 718254009631 ABC transporter signature motif; other site 718254009632 Walker B; other site 718254009633 D-loop; other site 718254009634 H-loop/switch region; other site 718254009635 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718254009636 lipid kinase; Reviewed; Region: PRK13054 718254009637 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 718254009638 putative protease; Provisional; Region: PRK15452 718254009639 Peptidase family U32; Region: Peptidase_U32; pfam01136 718254009640 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 718254009641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254009642 active site 718254009643 phosphorylation site [posttranslational modification] 718254009644 intermolecular recognition site; other site 718254009645 dimerization interface [polypeptide binding]; other site 718254009646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254009647 DNA binding site [nucleotide binding] 718254009648 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 718254009649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254009650 dimerization interface [polypeptide binding]; other site 718254009651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718254009652 dimer interface [polypeptide binding]; other site 718254009653 phosphorylation site [posttranslational modification] 718254009654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254009655 ATP binding site [chemical binding]; other site 718254009656 Mg2+ binding site [ion binding]; other site 718254009657 G-X-G motif; other site 718254009658 putative transporter; Provisional; Region: PRK10504 718254009659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009660 putative substrate translocation pore; other site 718254009661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009662 Protein export membrane protein; Region: SecD_SecF; cl14618 718254009663 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 718254009664 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254009665 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254009666 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 718254009667 AlkA N-terminal domain; Region: AlkA_N; pfam06029 718254009668 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718254009669 minor groove reading motif; other site 718254009670 helix-hairpin-helix signature motif; other site 718254009671 substrate binding pocket [chemical binding]; other site 718254009672 active site 718254009673 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 718254009674 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 718254009675 ATP-binding site [chemical binding]; other site 718254009676 Sugar specificity; other site 718254009677 Pyrimidine base specificity; other site 718254009678 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 718254009679 trimer interface [polypeptide binding]; other site 718254009680 active site 718254009681 putative assembly protein; Provisional; Region: PRK10833 718254009682 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 718254009683 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 718254009684 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 718254009685 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718254009686 Transporter associated domain; Region: CorC_HlyC; smart01091 718254009687 polysaccharide export protein Wza; Provisional; Region: PRK15078 718254009688 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 718254009689 SLBB domain; Region: SLBB; pfam10531 718254009690 Low molecular weight phosphatase family; Region: LMWPc; cd00115 718254009691 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 718254009692 active site 718254009693 tyrosine kinase; Provisional; Region: PRK11519 718254009694 Chain length determinant protein; Region: Wzz; pfam02706 718254009695 Chain length determinant protein; Region: Wzz; cl15801 718254009696 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 718254009697 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718254009698 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 718254009699 putative glycosyl transferase; Provisional; Region: PRK10063 718254009700 colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009 718254009701 active site 718254009702 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 718254009703 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 718254009704 putative trimer interface [polypeptide binding]; other site 718254009705 putative active site [active] 718254009706 putative substrate binding site [chemical binding]; other site 718254009707 putative CoA binding site [chemical binding]; other site 718254009708 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 718254009709 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 718254009710 NADP binding site [chemical binding]; other site 718254009711 active site 718254009712 putative substrate binding site [chemical binding]; other site 718254009713 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 718254009714 active site 718254009715 GDP-Mannose binding site [chemical binding]; other site 718254009716 dimer interface [polypeptide binding]; other site 718254009717 modified nudix motif 718254009718 metal binding site [ion binding]; metal-binding site 718254009719 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 718254009720 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 718254009721 colanic acid exporter; Provisional; Region: PRK10459 718254009722 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 718254009723 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 718254009724 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 718254009725 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 718254009726 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 718254009727 putative ADP-binding pocket [chemical binding]; other site 718254009728 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 718254009729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718254009730 active site 718254009731 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 718254009732 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 718254009733 NADP binding site [chemical binding]; other site 718254009734 active site 718254009735 putative substrate binding site [chemical binding]; other site 718254009736 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 718254009737 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 718254009738 substrate binding site; other site 718254009739 tetramer interface; other site 718254009740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718254009741 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718254009742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718254009743 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718254009744 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718254009745 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718254009746 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 718254009747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718254009748 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718254009749 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 718254009750 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 718254009751 Substrate binding site; other site 718254009752 Cupin domain; Region: Cupin_2; cl17218 718254009753 phosphomannomutase CpsG; Provisional; Region: PRK15414 718254009754 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 718254009755 active site 718254009756 substrate binding site [chemical binding]; other site 718254009757 metal binding site [ion binding]; metal-binding site 718254009758 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 718254009759 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 718254009760 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 718254009761 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 718254009762 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 718254009763 putative NAD(P) binding site [chemical binding]; other site 718254009764 active site 718254009765 putative substrate binding site [chemical binding]; other site 718254009766 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 718254009767 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 718254009768 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 718254009769 metal binding site [ion binding]; metal-binding site 718254009770 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 718254009771 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 718254009772 substrate binding site [chemical binding]; other site 718254009773 glutamase interaction surface [polypeptide binding]; other site 718254009774 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 718254009775 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 718254009776 catalytic residues [active] 718254009777 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 718254009778 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 718254009779 putative active site [active] 718254009780 oxyanion strand; other site 718254009781 catalytic triad [active] 718254009782 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 718254009783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254009784 active site 718254009785 motif I; other site 718254009786 motif II; other site 718254009787 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 718254009788 putative active site pocket [active] 718254009789 4-fold oligomerization interface [polypeptide binding]; other site 718254009790 metal binding residues [ion binding]; metal-binding site 718254009791 3-fold/trimer interface [polypeptide binding]; other site 718254009792 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 718254009793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254009794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254009795 homodimer interface [polypeptide binding]; other site 718254009796 catalytic residue [active] 718254009797 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 718254009798 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 718254009799 NAD binding site [chemical binding]; other site 718254009800 dimerization interface [polypeptide binding]; other site 718254009801 product binding site; other site 718254009802 substrate binding site [chemical binding]; other site 718254009803 zinc binding site [ion binding]; other site 718254009804 catalytic residues [active] 718254009805 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 718254009806 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 718254009807 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 718254009808 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 718254009809 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 718254009810 putative NAD(P) binding site [chemical binding]; other site 718254009811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254009812 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 718254009813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254009814 dimerization interface [polypeptide binding]; other site 718254009815 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 718254009816 exonuclease I; Provisional; Region: sbcB; PRK11779 718254009817 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 718254009818 active site 718254009819 catalytic site [active] 718254009820 substrate binding site [chemical binding]; other site 718254009821 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 718254009822 DNA gyrase inhibitor; Provisional; Region: PRK10016 718254009823 AMP nucleosidase; Provisional; Region: PRK08292 718254009824 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 718254009825 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 718254009826 shikimate transporter; Provisional; Region: PRK09952 718254009827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009828 putative substrate translocation pore; other site 718254009829 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 718254009830 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 718254009831 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 718254009832 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 718254009833 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254009834 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718254009835 Ligand Binding Site [chemical binding]; other site 718254009836 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 718254009837 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 718254009838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718254009839 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 718254009840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254009841 motif II; other site 718254009842 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 718254009843 L,D-transpeptidase; Provisional; Region: PRK10190 718254009844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 718254009845 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718254009846 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 718254009847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254009848 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 718254009849 putative dimerization interface [polypeptide binding]; other site 718254009850 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 718254009851 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 718254009852 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 718254009853 active site 718254009854 metal binding site [ion binding]; metal-binding site 718254009855 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 718254009856 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 718254009857 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 718254009858 active site 718254009859 metal binding site [ion binding]; metal-binding site 718254009860 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 718254009861 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 718254009862 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 718254009863 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254009864 N-terminal plug; other site 718254009865 ligand-binding site [chemical binding]; other site 718254009866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 718254009867 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 718254009868 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 718254009869 IucA / IucC family; Region: IucA_IucC; pfam04183 718254009870 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 718254009871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718254009873 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 718254009874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254009875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254009876 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 718254009877 putative dimerization interface [polypeptide binding]; other site 718254009878 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718254009879 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 718254009880 citrate-proton symporter; Provisional; Region: PRK15075 718254009881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254009882 putative substrate translocation pore; other site 718254009883 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 718254009884 Beta-lactamase; Region: Beta-lactamase; pfam00144 718254009885 fumarate hydratase; Provisional; Region: PRK15389 718254009886 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 718254009887 Fumarase C-terminus; Region: Fumerase_C; pfam05683 718254009888 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718254009889 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 718254009890 transmembrane helices; other site 718254009891 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 718254009892 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 718254009893 putative active site [active] 718254009894 putative FMN binding site [chemical binding]; other site 718254009895 putative substrate binding site [chemical binding]; other site 718254009896 putative catalytic residue [active] 718254009897 FMN-binding domain; Region: FMN_bind; cl01081 718254009898 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 718254009899 L-aspartate oxidase; Provisional; Region: PRK06175 718254009900 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 718254009901 ApbE family; Region: ApbE; pfam02424 718254009902 sensory histidine kinase DcuS; Provisional; Region: PRK11086 718254009903 PAS domain; Region: PAS; smart00091 718254009904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254009905 ATP binding site [chemical binding]; other site 718254009906 Mg2+ binding site [ion binding]; other site 718254009907 G-X-G motif; other site 718254009908 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 718254009909 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 718254009910 putative active site [active] 718254009911 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718254009912 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718254009913 trimer interface [polypeptide binding]; other site 718254009914 eyelet of channel; other site 718254009915 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 718254009916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718254009917 Zn2+ binding site [ion binding]; other site 718254009918 Mg2+ binding site [ion binding]; other site 718254009919 DNA cytosine methylase; Provisional; Region: PRK10458 718254009920 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 718254009921 cofactor binding site; other site 718254009922 DNA binding site [nucleotide binding] 718254009923 substrate interaction site [chemical binding]; other site 718254009924 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 718254009925 EamA-like transporter family; Region: EamA; pfam00892 718254009926 hypothetical protein; Provisional; Region: PRK10062 718254009927 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 718254009928 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 718254009929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254009930 active site 718254009931 motif I; other site 718254009932 motif II; other site 718254009933 hypothetical protein; Provisional; Region: PRK10708 718254009934 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 718254009935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254009936 DNA binding residues [nucleotide binding] 718254009937 dimerization interface [polypeptide binding]; other site 718254009938 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 718254009939 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 718254009940 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 718254009941 flagellar motor switch protein; Validated; Region: fliN; PRK05698 718254009942 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 718254009943 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 718254009944 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 718254009945 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 718254009946 flagellar hook-length control protein; Provisional; Region: PRK10118 718254009947 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 718254009948 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 718254009949 flagellar motor switch protein FliG; Region: fliG; TIGR00207 718254009950 FliG C-terminal domain; Region: FliG_C; pfam01706 718254009951 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 718254009952 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 718254009953 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 718254009954 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 718254009955 hypothetical protein; Provisional; Region: PRK09867 718254009956 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 718254009957 Helix-turn-helix domain; Region: HTH_18; pfam12833 718254009958 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 718254009959 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 718254009960 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 718254009961 Aspartase; Region: Aspartase; cd01357 718254009962 active sites [active] 718254009963 tetramer interface [polypeptide binding]; other site 718254009964 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 718254009965 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 718254009966 oligomerisation interface [polypeptide binding]; other site 718254009967 mobile loop; other site 718254009968 roof hairpin; other site 718254009969 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 718254009970 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 718254009971 ring oligomerisation interface [polypeptide binding]; other site 718254009972 ATP/Mg binding site [chemical binding]; other site 718254009973 stacking interactions; other site 718254009974 hinge regions; other site 718254009975 isoaspartyl dipeptidase; Provisional; Region: PRK10657 718254009976 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718254009977 active site 718254009978 hypothetical protein; Provisional; Region: PRK10519 718254009979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 718254009980 Nucleoside recognition; Region: Gate; pfam07670 718254009981 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 718254009982 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 718254009983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254009984 FeS/SAM binding site; other site 718254009985 elongation factor P; Validated; Region: PRK00529 718254009986 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 718254009987 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 718254009988 RNA binding site [nucleotide binding]; other site 718254009989 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 718254009990 RNA binding site [nucleotide binding]; other site 718254009991 Predicted small secreted protein [Function unknown]; Region: COG5510 718254009992 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 718254009993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718254009994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254009995 DNA binding residues [nucleotide binding] 718254009996 dimerization interface [polypeptide binding]; other site 718254009997 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 718254009998 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 718254009999 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 718254010000 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 718254010001 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 718254010002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254010003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718254010004 dimerization interface [polypeptide binding]; other site 718254010005 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 718254010006 D-subunit interface [polypeptide binding]; other site 718254010007 Iron-sulfur protein interface; other site 718254010008 proximal quinone binding site [chemical binding]; other site 718254010009 distal quinone binding site [chemical binding]; other site 718254010010 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 718254010011 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 718254010012 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 718254010013 L-aspartate oxidase; Provisional; Region: PRK06175 718254010014 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 718254010015 poxB regulator PoxA; Provisional; Region: PRK09350 718254010016 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718254010017 motif 1; other site 718254010018 dimer interface [polypeptide binding]; other site 718254010019 active site 718254010020 motif 2; other site 718254010021 motif 3; other site 718254010022 inner membrane transporter YjeM; Provisional; Region: PRK15238 718254010023 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 718254010024 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 718254010025 catalytic site [active] 718254010026 putative active site [active] 718254010027 putative substrate binding site [chemical binding]; other site 718254010028 dimer interface [polypeptide binding]; other site 718254010029 epoxyqueuosine reductase; Region: TIGR00276 718254010030 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 718254010031 putative carbohydrate kinase; Provisional; Region: PRK10565 718254010032 Uncharacterized conserved protein [Function unknown]; Region: COG0062 718254010033 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 718254010034 putative substrate binding site [chemical binding]; other site 718254010035 putative ATP binding site [chemical binding]; other site 718254010036 ADP-binding protein; Provisional; Region: PRK10646 718254010037 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 718254010038 AMIN domain; Region: AMIN; pfam11741 718254010039 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718254010040 active site 718254010041 metal binding site [ion binding]; metal-binding site 718254010042 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 718254010043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718254010044 ATP binding site [chemical binding]; other site 718254010045 Mg2+ binding site [ion binding]; other site 718254010046 G-X-G motif; other site 718254010047 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 718254010048 ATP binding site [chemical binding]; other site 718254010049 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 718254010050 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 718254010051 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 718254010052 FtsH protease regulator HflK; Provisional; Region: PRK10930 718254010053 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 718254010054 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 718254010055 FtsH protease regulator HflC; Provisional; Region: PRK11029 718254010056 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 718254010057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 718254010058 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 718254010059 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 718254010060 GDP-binding site [chemical binding]; other site 718254010061 ACT binding site; other site 718254010062 IMP binding site; other site 718254010063 exoribonuclease R; Provisional; Region: PRK11642 718254010064 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 718254010065 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718254010066 RNB domain; Region: RNB; pfam00773 718254010067 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 718254010068 RNA binding site [nucleotide binding]; other site 718254010069 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 718254010070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 718254010071 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 718254010072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254010073 metabolite-proton symporter; Region: 2A0106; TIGR00883 718254010074 putative substrate translocation pore; other site 718254010075 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 718254010076 active site 718254010077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254010078 dimerization interface [polypeptide binding]; other site 718254010079 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 718254010080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254010081 dimer interface [polypeptide binding]; other site 718254010082 putative CheW interface [polypeptide binding]; other site 718254010083 esterase; Provisional; Region: PRK10566 718254010084 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 718254010085 transcriptional repressor UlaR; Provisional; Region: PRK13509 718254010086 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 718254010087 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718254010088 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 718254010089 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 718254010090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 718254010091 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 718254010092 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 718254010093 active site 718254010094 P-loop; other site 718254010095 phosphorylation site [posttranslational modification] 718254010096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254010097 active site 718254010098 phosphorylation site [posttranslational modification] 718254010099 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 718254010100 active site 718254010101 dimer interface [polypeptide binding]; other site 718254010102 magnesium binding site [ion binding]; other site 718254010103 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 718254010104 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 718254010105 AP (apurinic/apyrimidinic) site pocket; other site 718254010106 DNA interaction; other site 718254010107 Metal-binding active site; metal-binding site 718254010108 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718254010109 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 718254010110 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 718254010111 dimer interface [polypeptide binding]; other site 718254010112 ssDNA binding site [nucleotide binding]; other site 718254010113 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718254010114 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 718254010115 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 718254010116 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 718254010117 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 718254010118 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 718254010119 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 718254010120 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 718254010121 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 718254010122 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718254010123 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 718254010124 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 718254010125 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 718254010126 Hemerythrin-like domain; Region: Hr-like; cd12108 718254010127 Fe binding site [ion binding]; other site 718254010128 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 718254010129 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718254010130 dimer interface [polypeptide binding]; other site 718254010131 ligand binding site [chemical binding]; other site 718254010132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254010133 dimerization interface [polypeptide binding]; other site 718254010134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254010135 dimer interface [polypeptide binding]; other site 718254010136 putative CheW interface [polypeptide binding]; other site 718254010137 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718254010138 EamA-like transporter family; Region: EamA; pfam00892 718254010139 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 718254010140 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 718254010141 NADP binding site [chemical binding]; other site 718254010142 Predicted transcriptional regulators [Transcription]; Region: COG1733 718254010143 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 718254010144 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 718254010145 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 718254010146 active site 718254010147 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 718254010148 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 718254010149 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 718254010150 Domain of unknown function DUF21; Region: DUF21; pfam01595 718254010151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718254010152 Transporter associated domain; Region: CorC_HlyC; smart01091 718254010153 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718254010154 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718254010155 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 718254010156 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718254010157 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718254010158 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 718254010159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718254010160 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 718254010161 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718254010162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718254010163 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 718254010164 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254010165 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254010166 DNA binding site [nucleotide binding] 718254010167 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 718254010168 ligand binding site [chemical binding]; other site 718254010169 dimerization interface [polypeptide binding]; other site 718254010170 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 718254010171 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 718254010172 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718254010173 Surface antigen; Region: Bac_surface_Ag; pfam01103 718254010174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 718254010175 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 718254010176 dimerization interface [polypeptide binding]; other site 718254010177 putative active site pocket [active] 718254010178 putative catalytic residue [active] 718254010179 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 718254010180 dimer interface [polypeptide binding]; other site 718254010181 substrate binding site [chemical binding]; other site 718254010182 metal binding sites [ion binding]; metal-binding site 718254010183 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 718254010184 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 718254010185 putative ligand binding site [chemical binding]; other site 718254010186 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 718254010187 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718254010188 Walker A/P-loop; other site 718254010189 ATP binding site [chemical binding]; other site 718254010190 Q-loop/lid; other site 718254010191 ABC transporter signature motif; other site 718254010192 Walker B; other site 718254010193 D-loop; other site 718254010194 H-loop/switch region; other site 718254010195 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254010196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254010197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254010198 TM-ABC transporter signature motif; other site 718254010199 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254010200 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254010201 TM-ABC transporter signature motif; other site 718254010202 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 718254010203 dimer interface [polypeptide binding]; other site 718254010204 ligand binding site [chemical binding]; other site 718254010205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 718254010206 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 718254010207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254010208 dimer interface [polypeptide binding]; other site 718254010209 putative CheW interface [polypeptide binding]; other site 718254010210 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 718254010211 AMP binding site [chemical binding]; other site 718254010212 metal binding site [ion binding]; metal-binding site 718254010213 active site 718254010214 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 718254010215 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718254010216 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718254010217 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718254010218 hypothetical protein; Provisional; Region: PRK05255 718254010219 peptidase PmbA; Provisional; Region: PRK11040 718254010220 cytochrome b562; Provisional; Region: PRK15058 718254010221 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 718254010222 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 718254010223 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 718254010224 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 718254010225 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 718254010226 dihydroorotase; Provisional; Region: PRK09237 718254010227 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 718254010228 active site 718254010229 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 718254010230 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 718254010231 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 718254010232 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 718254010233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718254010234 FeS/SAM binding site; other site 718254010235 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 718254010236 ATP cone domain; Region: ATP-cone; pfam03477 718254010237 Class III ribonucleotide reductase; Region: RNR_III; cd01675 718254010238 effector binding site; other site 718254010239 active site 718254010240 Zn binding site [ion binding]; other site 718254010241 glycine loop; other site 718254010242 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254010243 active site 718254010244 phosphorylation site [posttranslational modification] 718254010245 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 718254010246 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718254010247 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718254010248 putative active site [active] 718254010249 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 718254010250 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 718254010251 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 718254010252 Ca binding site [ion binding]; other site 718254010253 active site 718254010254 catalytic site [active] 718254010255 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 718254010256 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 718254010257 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718254010258 active site turn [active] 718254010259 phosphorylation site [posttranslational modification] 718254010260 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718254010261 trehalose repressor; Provisional; Region: treR; PRK09492 718254010262 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254010263 DNA binding site [nucleotide binding] 718254010264 domain linker motif; other site 718254010265 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 718254010266 dimerization interface [polypeptide binding]; other site 718254010267 ligand binding site [chemical binding]; other site 718254010268 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 718254010269 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 718254010270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718254010271 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 718254010272 Soluble P-type ATPase [General function prediction only]; Region: COG4087 718254010273 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 718254010274 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 718254010275 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 718254010276 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 718254010277 active site 718254010278 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 718254010279 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 718254010280 Chitin binding domain; Region: Chitin_bind_3; pfam03067 718254010281 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 718254010282 homotrimer interaction site [polypeptide binding]; other site 718254010283 putative active site [active] 718254010284 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 718254010285 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 718254010286 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 718254010287 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 718254010288 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 718254010289 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 718254010290 Arginine repressor [Transcription]; Region: ArgR; COG1438 718254010291 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 718254010292 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 718254010293 Predicted membrane protein [Function unknown]; Region: COG1288 718254010294 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 718254010295 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 718254010296 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 718254010297 putative substrate binding site [chemical binding]; other site 718254010298 nucleotide binding site [chemical binding]; other site 718254010299 nucleotide binding site [chemical binding]; other site 718254010300 homodimer interface [polypeptide binding]; other site 718254010301 arginine deiminase; Provisional; Region: PRK01388 718254010302 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 718254010303 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 718254010304 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 718254010305 inhibitor site; inhibition site 718254010306 active site 718254010307 dimer interface [polypeptide binding]; other site 718254010308 catalytic residue [active] 718254010309 putative dehydratase; Provisional; Region: PRK08211 718254010310 Dehydratase family; Region: ILVD_EDD; cl00340 718254010311 putative symporter YagG; Provisional; Region: PRK09669 718254010312 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 718254010313 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 718254010314 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 718254010315 inhibitor binding site; inhibition site 718254010316 active site 718254010317 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 718254010318 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 718254010319 Transcriptional regulator [Transcription]; Region: IclR; COG1414 718254010320 Bacterial transcriptional regulator; Region: IclR; pfam01614 718254010321 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 718254010322 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 718254010323 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 718254010324 RNase E inhibitor protein; Provisional; Region: PRK11191 718254010325 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 718254010326 active site 718254010327 dinuclear metal binding site [ion binding]; other site 718254010328 dimerization interface [polypeptide binding]; other site 718254010329 integrase; Provisional; Region: PRK09692 718254010330 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718254010331 active site 718254010332 Int/Topo IB signature motif; other site 718254010333 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 718254010334 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 718254010335 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718254010336 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 718254010337 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 718254010338 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 718254010339 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718254010340 AAA-like domain; Region: AAA_10; pfam12846 718254010341 Walker A motif; other site 718254010342 ATP binding site [chemical binding]; other site 718254010343 Walker B motif; other site 718254010344 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 718254010345 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 718254010346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254010347 ABC transporter signature motif; other site 718254010348 Walker B; other site 718254010349 D-loop; other site 718254010350 H-loop/switch region; other site 718254010351 hypothetical protein; Provisional; Region: PRK06850 718254010352 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 718254010353 DNA-sulfur modification-associated; Region: DndB; pfam14072 718254010354 DGQHR domain; Region: DGQHR; TIGR03187 718254010355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254010356 non-specific DNA binding site [nucleotide binding]; other site 718254010357 salt bridge; other site 718254010358 sequence-specific DNA binding site [nucleotide binding]; other site 718254010359 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 718254010360 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 718254010361 PAAR motif; Region: PAAR_motif; pfam05488 718254010362 S-type Pyocin; Region: Pyocin_S; pfam06958 718254010363 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 718254010364 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 718254010365 active site 718254010366 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 718254010367 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 718254010368 active site 718254010369 HIGH motif; other site 718254010370 dimer interface [polypeptide binding]; other site 718254010371 KMSKS motif; other site 718254010372 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 718254010373 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 718254010374 dimer interface [polypeptide binding]; other site 718254010375 Mn binding site [ion binding]; other site 718254010376 K binding site [ion binding]; other site 718254010377 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254010378 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254010379 DNA binding site [nucleotide binding] 718254010380 domain linker motif; other site 718254010381 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 718254010382 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 718254010383 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 718254010384 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718254010385 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 718254010386 Transmembrane secretion effector; Region: MFS_3; pfam05977 718254010387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254010388 putative substrate translocation pore; other site 718254010389 DoxX; Region: DoxX; pfam07681 718254010390 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 718254010391 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 718254010392 active site 718254010393 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 718254010394 Isochorismatase family; Region: Isochorismatase; pfam00857 718254010395 catalytic triad [active] 718254010396 dimer interface [polypeptide binding]; other site 718254010397 conserved cis-peptide bond; other site 718254010398 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 718254010399 Response regulator receiver domain; Region: Response_reg; pfam00072 718254010400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254010401 active site 718254010402 phosphorylation site [posttranslational modification] 718254010403 intermolecular recognition site; other site 718254010404 dimerization interface [polypeptide binding]; other site 718254010405 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 718254010406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254010407 active site 718254010408 phosphorylation site [posttranslational modification] 718254010409 intermolecular recognition site; other site 718254010410 dimerization interface [polypeptide binding]; other site 718254010411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254010412 DNA binding residues [nucleotide binding] 718254010413 dimerization interface [polypeptide binding]; other site 718254010414 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 718254010415 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718254010416 active site 718254010417 metal binding site [ion binding]; metal-binding site 718254010418 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 718254010419 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 718254010420 oligomer interface [polypeptide binding]; other site 718254010421 active site residues [active] 718254010422 Uncharacterized conserved protein [Function unknown]; Region: COG2850 718254010423 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 718254010424 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 718254010425 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 718254010426 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254010427 N-terminal plug; other site 718254010428 ligand-binding site [chemical binding]; other site 718254010429 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 718254010430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254010431 DNA-binding site [nucleotide binding]; DNA binding site 718254010432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254010433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254010434 homodimer interface [polypeptide binding]; other site 718254010435 catalytic residue [active] 718254010436 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 718254010437 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 718254010438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254010439 DNA-binding site [nucleotide binding]; DNA binding site 718254010440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254010441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254010442 homodimer interface [polypeptide binding]; other site 718254010443 catalytic residue [active] 718254010444 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 718254010445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254010446 dimerization interface [polypeptide binding]; other site 718254010447 putative DNA binding site [nucleotide binding]; other site 718254010448 putative Zn2+ binding site [ion binding]; other site 718254010449 transcriptional regulator SlyA; Provisional; Region: PRK03573 718254010450 MarR family; Region: MarR_2; cl17246 718254010451 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 718254010452 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718254010453 HlyD family secretion protein; Region: HlyD_3; pfam13437 718254010454 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 718254010455 Protein of unknown function (DUF445); Region: DUF445; pfam04286 718254010456 Protein of unknown function (DUF497); Region: DUF497; cl01108 718254010457 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 718254010458 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 718254010459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718254010460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254010461 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 718254010462 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 718254010463 NAD(P) binding site [chemical binding]; other site 718254010464 catalytic residues [active] 718254010465 YfaZ precursor; Region: YfaZ; pfam07437 718254010466 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 718254010467 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 718254010468 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 718254010469 P-loop, Walker A motif; other site 718254010470 Base recognition motif; other site 718254010471 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 718254010472 Uncharacterized small protein [Function unknown]; Region: COG2879 718254010473 HTH domain; Region: HTH_11; cl17392 718254010474 Flavin Reductases; Region: FlaRed; cl00801 718254010475 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 718254010476 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 718254010477 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 718254010478 Cupin domain; Region: Cupin_2; pfam07883 718254010479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254010480 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 718254010481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254010482 putative substrate translocation pore; other site 718254010483 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 718254010484 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 718254010485 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 718254010486 putative substrate binding pocket [chemical binding]; other site 718254010487 trimer interface [polypeptide binding]; other site 718254010488 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 718254010489 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 718254010490 putative active site [active] 718254010491 putative metal binding site [ion binding]; other site 718254010492 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 718254010493 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 718254010494 NAD binding site [chemical binding]; other site 718254010495 catalytic residues [active] 718254010496 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 718254010497 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 718254010498 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 718254010499 MarR family; Region: MarR_2; cl17246 718254010500 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 718254010501 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718254010502 dimer interface [polypeptide binding]; other site 718254010503 ligand binding site [chemical binding]; other site 718254010504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718254010505 dimerization interface [polypeptide binding]; other site 718254010506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718254010507 dimer interface [polypeptide binding]; other site 718254010508 putative CheW interface [polypeptide binding]; other site 718254010509 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 718254010510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718254010511 Coenzyme A binding pocket [chemical binding]; other site 718254010512 phosphoglycerol transferase I; Provisional; Region: PRK03776 718254010513 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 718254010514 hypothetical protein; Provisional; Region: PRK11667 718254010515 DNA replication protein DnaC; Validated; Region: PRK07952 718254010516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254010517 Walker A motif; other site 718254010518 ATP binding site [chemical binding]; other site 718254010519 Walker B motif; other site 718254010520 primosomal protein DnaI; Provisional; Region: PRK02854 718254010521 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 718254010522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 718254010523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718254010524 putative Zn2+ binding site [ion binding]; other site 718254010525 putative DNA binding site [nucleotide binding]; other site 718254010526 hypothetical protein; Provisional; Region: PRK09917 718254010527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718254010528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254010529 DNA binding residues [nucleotide binding] 718254010530 dimerization interface [polypeptide binding]; other site 718254010531 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 718254010532 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718254010533 DNA binding residues [nucleotide binding] 718254010534 dimerization interface [polypeptide binding]; other site 718254010535 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 718254010536 putative deacylase active site [active] 718254010537 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 718254010538 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 718254010539 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 718254010540 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 718254010541 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 718254010542 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 718254010543 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 718254010544 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 718254010545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254010546 S-adenosylmethionine binding site [chemical binding]; other site 718254010547 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 718254010548 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718254010549 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 718254010550 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 718254010551 G1 box; other site 718254010552 putative GEF interaction site [polypeptide binding]; other site 718254010553 GTP/Mg2+ binding site [chemical binding]; other site 718254010554 Switch I region; other site 718254010555 G2 box; other site 718254010556 G3 box; other site 718254010557 Switch II region; other site 718254010558 G4 box; other site 718254010559 G5 box; other site 718254010560 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 718254010561 periplasmic protein; Provisional; Region: PRK10568 718254010562 BON domain; Region: BON; pfam04972 718254010563 BON domain; Region: BON; pfam04972 718254010564 hypothetical protein; Provisional; Region: PRK10977 718254010565 Class I aldolases; Region: Aldolase_Class_I; cl17187 718254010566 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 718254010567 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 718254010568 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 718254010569 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 718254010570 phosphopentomutase; Provisional; Region: PRK05362 718254010571 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 718254010572 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 718254010573 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 718254010574 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 718254010575 hypothetical protein; Provisional; Region: PRK11246 718254010576 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 718254010577 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718254010578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718254010579 motif II; other site 718254010580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718254010581 non-specific DNA binding site [nucleotide binding]; other site 718254010582 salt bridge; other site 718254010583 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 718254010584 sequence-specific DNA binding site [nucleotide binding]; other site 718254010585 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 718254010586 active site 718254010587 (T/H)XGH motif; other site 718254010588 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 718254010589 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 718254010590 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 718254010591 putative NAD(P) binding site [chemical binding]; other site 718254010592 dimer interface [polypeptide binding]; other site 718254010593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718254010594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254010595 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 718254010596 putative effector binding pocket; other site 718254010597 dimerization interface [polypeptide binding]; other site 718254010598 Trp operon repressor; Provisional; Region: PRK01381 718254010599 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 718254010600 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718254010601 catalytic core [active] 718254010602 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 718254010603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254010604 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 718254010605 hypothetical protein; Provisional; Region: PRK10756 718254010606 CreA protein; Region: CreA; pfam05981 718254010607 two-component response regulator; Provisional; Region: PRK11173 718254010608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718254010609 active site 718254010610 phosphorylation site [posttranslational modification] 718254010611 intermolecular recognition site; other site 718254010612 dimerization interface [polypeptide binding]; other site 718254010613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718254010614 DNA binding site [nucleotide binding] 718254010615 putative RNA methyltransferase; Provisional; Region: PRK10433 718254010616 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 718254010617 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 718254010618 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 718254010619 putative catalytic residues [active] 718254010620 putative nucleotide binding site [chemical binding]; other site 718254010621 putative aspartate binding site [chemical binding]; other site 718254010622 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 718254010623 dimer interface [polypeptide binding]; other site 718254010624 putative threonine allosteric regulatory site; other site 718254010625 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 718254010626 putative threonine allosteric regulatory site; other site 718254010627 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 718254010628 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 718254010629 homoserine kinase; Provisional; Region: PRK01212 718254010630 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718254010631 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 718254010632 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 718254010633 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 718254010634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254010635 catalytic residue [active] 718254010636 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 718254010637 hypothetical protein; Validated; Region: PRK02101 718254010638 transaldolase-like protein; Provisional; Region: PTZ00411 718254010639 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 718254010640 active site 718254010641 dimer interface [polypeptide binding]; other site 718254010642 catalytic residue [active] 718254010643 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 718254010644 MPT binding site; other site 718254010645 trimer interface [polypeptide binding]; other site 718254010646 metabolite-proton symporter; Region: 2A0106; TIGR00883 718254010647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254010648 putative substrate translocation pore; other site 718254010649 hypothetical protein; Provisional; Region: PRK10659 718254010650 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 718254010651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 718254010652 nucleotide binding site [chemical binding]; other site 718254010653 chaperone protein DnaJ; Provisional; Region: PRK10767 718254010654 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718254010655 HSP70 interaction site [polypeptide binding]; other site 718254010656 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 718254010657 substrate binding site [polypeptide binding]; other site 718254010658 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 718254010659 Zn binding sites [ion binding]; other site 718254010660 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 718254010661 dimer interface [polypeptide binding]; other site 718254010662 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 718254010663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718254010664 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 718254010665 putative dimerization interface [polypeptide binding]; other site 718254010666 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 718254010667 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 718254010668 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 718254010669 active site 718254010670 Riboflavin kinase; Region: Flavokinase; smart00904 718254010671 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 718254010672 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 718254010673 HIGH motif; other site 718254010674 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 718254010675 active site 718254010676 KMSKS motif; other site 718254010677 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 718254010678 tRNA binding surface [nucleotide binding]; other site 718254010679 anticodon binding site; other site 718254010680 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 718254010681 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 718254010682 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 718254010683 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718254010684 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 718254010685 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 718254010686 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 718254010687 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 718254010688 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 718254010689 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 718254010690 active site 718254010691 phosphorylation site [posttranslational modification] 718254010692 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 718254010693 active pocket/dimerization site; other site 718254010694 active site 718254010695 phosphorylation site [posttranslational modification] 718254010696 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 718254010697 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 718254010698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254010699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718254010700 DNA binding site [nucleotide binding] 718254010701 domain linker motif; other site 718254010702 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 718254010703 putative ligand binding site [chemical binding]; other site 718254010704 putative dimerization interface [polypeptide binding]; other site 718254010705 dihydrodipicolinate reductase; Provisional; Region: PRK00048 718254010706 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 718254010707 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 718254010708 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 718254010709 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 718254010710 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 718254010711 catalytic site [active] 718254010712 subunit interface [polypeptide binding]; other site 718254010713 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 718254010714 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718254010715 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 718254010716 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 718254010717 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718254010718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 718254010719 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 718254010720 IMP binding site; other site 718254010721 dimer interface [polypeptide binding]; other site 718254010722 interdomain contacts; other site 718254010723 partial ornithine binding site; other site 718254010724 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 718254010725 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 718254010726 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 718254010727 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 718254010728 TrkA-N domain; Region: TrkA_N; pfam02254 718254010729 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 718254010730 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 718254010731 active site 718254010732 metal binding site [ion binding]; metal-binding site 718254010733 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 718254010734 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 718254010735 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 718254010736 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 718254010737 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 718254010738 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 718254010739 SurA N-terminal domain; Region: SurA_N; pfam09312 718254010740 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 718254010741 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 718254010742 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 718254010743 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 718254010744 putative metal binding site [ion binding]; other site 718254010745 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718254010746 HSP70 interaction site [polypeptide binding]; other site 718254010747 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718254010748 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718254010749 active site 718254010750 ATP-dependent helicase HepA; Validated; Region: PRK04914 718254010751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718254010752 ATP binding site [chemical binding]; other site 718254010753 putative Mg++ binding site [ion binding]; other site 718254010754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718254010755 nucleotide binding region [chemical binding]; other site 718254010756 ATP-binding site [chemical binding]; other site 718254010757 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 718254010758 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 718254010759 intersubunit interface [polypeptide binding]; other site 718254010760 active site 718254010761 Zn2+ binding site [ion binding]; other site 718254010762 L-arabinose isomerase; Provisional; Region: PRK02929 718254010763 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 718254010764 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 718254010765 trimer interface [polypeptide binding]; other site 718254010766 putative substrate binding site [chemical binding]; other site 718254010767 putative metal binding site [ion binding]; other site 718254010768 ribulokinase; Provisional; Region: PRK04123 718254010769 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 718254010770 N- and C-terminal domain interface [polypeptide binding]; other site 718254010771 active site 718254010772 MgATP binding site [chemical binding]; other site 718254010773 catalytic site [active] 718254010774 metal binding site [ion binding]; metal-binding site 718254010775 carbohydrate binding site [chemical binding]; other site 718254010776 homodimer interface [polypeptide binding]; other site 718254010777 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 718254010778 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 718254010779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254010780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254010781 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718254010782 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718254010783 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 718254010784 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 718254010785 Walker A/P-loop; other site 718254010786 ATP binding site [chemical binding]; other site 718254010787 Q-loop/lid; other site 718254010788 ABC transporter signature motif; other site 718254010789 Walker B; other site 718254010790 D-loop; other site 718254010791 H-loop/switch region; other site 718254010792 transcriptional regulator SgrR; Provisional; Region: PRK13626 718254010793 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 718254010794 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 718254010795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254010796 sugar efflux transporter; Region: 2A0120; TIGR00899 718254010797 putative substrate translocation pore; other site 718254010798 Hok/gef family; Region: HOK_GEF; pfam01848 718254010799 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 718254010800 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 718254010801 substrate binding site [chemical binding]; other site 718254010802 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 718254010803 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 718254010804 substrate binding site [chemical binding]; other site 718254010805 ligand binding site [chemical binding]; other site 718254010806 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 718254010807 tartrate dehydrogenase; Region: TTC; TIGR02089 718254010808 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 718254010809 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 718254010810 PYR/PP interface [polypeptide binding]; other site 718254010811 dimer interface [polypeptide binding]; other site 718254010812 TPP binding site [chemical binding]; other site 718254010813 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718254010814 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 718254010815 TPP-binding site [chemical binding]; other site 718254010816 dimer interface [polypeptide binding]; other site 718254010817 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 718254010818 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 718254010819 putative valine binding site [chemical binding]; other site 718254010820 dimer interface [polypeptide binding]; other site 718254010821 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 718254010822 cell division protein MraZ; Reviewed; Region: PRK00326 718254010823 MraZ protein; Region: MraZ; pfam02381 718254010824 MraZ protein; Region: MraZ; pfam02381 718254010825 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 718254010826 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 718254010827 cell division protein FtsL; Provisional; Region: PRK10772 718254010828 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 718254010829 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718254010830 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718254010831 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 718254010832 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718254010833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718254010834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718254010835 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 718254010836 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718254010837 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718254010838 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718254010839 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 718254010840 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 718254010841 Mg++ binding site [ion binding]; other site 718254010842 putative catalytic motif [active] 718254010843 putative substrate binding site [chemical binding]; other site 718254010844 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 718254010845 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718254010846 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718254010847 cell division protein FtsW; Provisional; Region: PRK10774 718254010848 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 718254010849 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 718254010850 active site 718254010851 homodimer interface [polypeptide binding]; other site 718254010852 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 718254010853 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718254010854 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718254010855 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718254010856 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 718254010857 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 718254010858 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 718254010859 cell division protein FtsQ; Provisional; Region: PRK10775 718254010860 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 718254010861 Cell division protein FtsQ; Region: FtsQ; pfam03799 718254010862 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 718254010863 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718254010864 Cell division protein FtsA; Region: FtsA; pfam14450 718254010865 cell division protein FtsZ; Validated; Region: PRK09330 718254010866 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 718254010867 nucleotide binding site [chemical binding]; other site 718254010868 SulA interaction site; other site 718254010869 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 718254010870 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 718254010871 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 718254010872 SecA regulator SecM; Provisional; Region: PRK02943 718254010873 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 718254010874 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 718254010875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 718254010876 nucleotide binding region [chemical binding]; other site 718254010877 ATP-binding site [chemical binding]; other site 718254010878 SEC-C motif; Region: SEC-C; pfam02810 718254010879 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 718254010880 active site 718254010881 8-oxo-dGMP binding site [chemical binding]; other site 718254010882 nudix motif; other site 718254010883 metal binding site [ion binding]; metal-binding site 718254010884 DNA gyrase inhibitor; Reviewed; Region: PRK00418 718254010885 hypothetical protein; Provisional; Region: PRK05287 718254010886 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 718254010887 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 718254010888 CoA-binding site [chemical binding]; other site 718254010889 ATP-binding [chemical binding]; other site 718254010890 type IV pilin biogenesis protein; Provisional; Region: PRK10573 718254010891 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718254010892 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718254010893 hypothetical protein; Provisional; Region: PRK10436 718254010894 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 718254010895 Walker A motif; other site 718254010896 ATP binding site [chemical binding]; other site 718254010897 Walker B motif; other site 718254010898 putative major pilin subunit; Provisional; Region: PRK10574 718254010899 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 718254010900 Pilin (bacterial filament); Region: Pilin; pfam00114 718254010901 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 718254010902 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 718254010903 dimerization interface [polypeptide binding]; other site 718254010904 active site 718254010905 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 718254010906 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 718254010907 amidase catalytic site [active] 718254010908 Zn binding residues [ion binding]; other site 718254010909 substrate binding site [chemical binding]; other site 718254010910 regulatory protein AmpE; Provisional; Region: PRK10987 718254010911 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 718254010912 active site 718254010913 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 718254010914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254010915 putative substrate translocation pore; other site 718254010916 aromatic amino acid transporter; Provisional; Region: PRK10238 718254010917 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 718254010918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254010919 DNA-binding site [nucleotide binding]; DNA binding site 718254010920 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718254010921 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 718254010922 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 718254010923 dimer interface [polypeptide binding]; other site 718254010924 TPP-binding site [chemical binding]; other site 718254010925 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 718254010926 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718254010927 E3 interaction surface; other site 718254010928 lipoyl attachment site [posttranslational modification]; other site 718254010929 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718254010930 E3 interaction surface; other site 718254010931 lipoyl attachment site [posttranslational modification]; other site 718254010932 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718254010933 E3 interaction surface; other site 718254010934 lipoyl attachment site [posttranslational modification]; other site 718254010935 e3 binding domain; Region: E3_binding; pfam02817 718254010936 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 718254010937 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 718254010938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718254010939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718254010940 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718254010941 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 718254010942 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 718254010943 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 718254010944 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 718254010945 substrate binding site [chemical binding]; other site 718254010946 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 718254010947 substrate binding site [chemical binding]; other site 718254010948 ligand binding site [chemical binding]; other site 718254010949 hypothetical protein; Provisional; Region: PRK05248 718254010950 spermidine synthase; Provisional; Region: PRK00811 718254010951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718254010952 S-adenosylmethionine binding site [chemical binding]; other site 718254010953 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 718254010954 multicopper oxidase; Provisional; Region: PRK10965 718254010955 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 718254010956 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 718254010957 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 718254010958 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 718254010959 Trp docking motif [polypeptide binding]; other site 718254010960 putative active site [active] 718254010961 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 718254010962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718254010963 active site 718254010964 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 718254010965 active site clefts [active] 718254010966 zinc binding site [ion binding]; other site 718254010967 dimer interface [polypeptide binding]; other site 718254010968 inner membrane transport permease; Provisional; Region: PRK15066 718254010969 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 718254010970 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 718254010971 active pocket/dimerization site; other site 718254010972 active site 718254010973 phosphorylation site [posttranslational modification] 718254010974 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 718254010975 putative active site [active] 718254010976 putative metal binding site [ion binding]; other site 718254010977 Fimbrial protein; Region: Fimbrial; cl01416 718254010978 Fimbrial protein; Region: Fimbrial; cl01416 718254010979 putative fimbrial protein StaE; Provisional; Region: PRK15263 718254010980 Fimbrial protein; Region: Fimbrial; cl01416 718254010981 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 718254010982 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254010983 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254010984 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 718254010985 tetramerization interface [polypeptide binding]; other site 718254010986 active site 718254010987 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 718254010988 oligomerization interface [polypeptide binding]; other site 718254010989 active site 718254010990 metal binding site [ion binding]; metal-binding site 718254010991 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 718254010992 catalytic center binding site [active] 718254010993 ATP binding site [chemical binding]; other site 718254010994 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 718254010995 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 718254010996 2'-5' RNA ligase; Provisional; Region: PRK15124 718254010997 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 718254010998 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 718254010999 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 718254011000 Transglycosylase; Region: Transgly; pfam00912 718254011001 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 718254011002 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254011003 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 718254011004 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718254011005 N-terminal plug; other site 718254011006 ligand-binding site [chemical binding]; other site 718254011007 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 718254011008 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718254011009 Walker A/P-loop; other site 718254011010 ATP binding site [chemical binding]; other site 718254011011 Q-loop/lid; other site 718254011012 ABC transporter signature motif; other site 718254011013 Walker B; other site 718254011014 D-loop; other site 718254011015 H-loop/switch region; other site 718254011016 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 718254011017 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 718254011018 siderophore binding site; other site 718254011019 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718254011020 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254011021 ABC-ATPase subunit interface; other site 718254011022 dimer interface [polypeptide binding]; other site 718254011023 putative PBP binding regions; other site 718254011024 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718254011025 ABC-ATPase subunit interface; other site 718254011026 dimer interface [polypeptide binding]; other site 718254011027 putative PBP binding regions; other site 718254011028 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 718254011029 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718254011030 inhibitor-cofactor binding pocket; inhibition site 718254011031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254011032 catalytic residue [active] 718254011033 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 718254011034 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 718254011035 Cl- selectivity filter; other site 718254011036 Cl- binding residues [ion binding]; other site 718254011037 pore gating glutamate residue; other site 718254011038 dimer interface [polypeptide binding]; other site 718254011039 H+/Cl- coupling transport residue; other site 718254011040 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 718254011041 UPF0126 domain; Region: UPF0126; pfam03458 718254011042 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 718254011043 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 718254011044 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 718254011045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718254011046 Zn2+ binding site [ion binding]; other site 718254011047 Mg2+ binding site [ion binding]; other site 718254011048 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 718254011049 serine endoprotease; Provisional; Region: PRK10942 718254011050 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718254011051 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718254011052 protein binding site [polypeptide binding]; other site 718254011053 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718254011054 hypothetical protein; Provisional; Region: PRK13677 718254011055 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 718254011056 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 718254011057 trimer interface [polypeptide binding]; other site 718254011058 active site 718254011059 substrate binding site [chemical binding]; other site 718254011060 CoA binding site [chemical binding]; other site 718254011061 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 718254011062 metal binding triad; other site 718254011063 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 718254011064 active site 718254011065 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 718254011066 rRNA interaction site [nucleotide binding]; other site 718254011067 S8 interaction site; other site 718254011068 putative laminin-1 binding site; other site 718254011069 elongation factor Ts; Provisional; Region: tsf; PRK09377 718254011070 UBA/TS-N domain; Region: UBA; pfam00627 718254011071 Elongation factor TS; Region: EF_TS; pfam00889 718254011072 Elongation factor TS; Region: EF_TS; pfam00889 718254011073 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 718254011074 putative nucleotide binding site [chemical binding]; other site 718254011075 uridine monophosphate binding site [chemical binding]; other site 718254011076 homohexameric interface [polypeptide binding]; other site 718254011077 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 718254011078 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 718254011079 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 718254011080 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 718254011081 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 718254011082 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 718254011083 catalytic residue [active] 718254011084 putative FPP diphosphate binding site; other site 718254011085 putative FPP binding hydrophobic cleft; other site 718254011086 dimer interface [polypeptide binding]; other site 718254011087 putative IPP diphosphate binding site; other site 718254011088 zinc metallopeptidase RseP; Provisional; Region: PRK10779 718254011089 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 718254011090 active site 718254011091 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 718254011092 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 718254011093 protein binding site [polypeptide binding]; other site 718254011094 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 718254011095 putative substrate binding region [chemical binding]; other site 718254011096 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 718254011097 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718254011098 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718254011099 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718254011100 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718254011101 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718254011102 Surface antigen; Region: Bac_surface_Ag; pfam01103 718254011103 periplasmic chaperone; Provisional; Region: PRK10780 718254011104 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 718254011105 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 718254011106 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 718254011107 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 718254011108 trimer interface [polypeptide binding]; other site 718254011109 active site 718254011110 UDP-GlcNAc binding site [chemical binding]; other site 718254011111 lipid binding site [chemical binding]; lipid-binding site 718254011112 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 718254011113 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 718254011114 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 718254011115 RNA/DNA hybrid binding site [nucleotide binding]; other site 718254011116 active site 718254011117 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 718254011118 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 718254011119 putative active site [active] 718254011120 putative PHP Thumb interface [polypeptide binding]; other site 718254011121 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 718254011122 generic binding surface II; other site 718254011123 generic binding surface I; other site 718254011124 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 718254011125 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 718254011126 lysine decarboxylase LdcC; Provisional; Region: PRK15399 718254011127 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718254011128 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 718254011129 homodimer interface [polypeptide binding]; other site 718254011130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254011131 catalytic residue [active] 718254011132 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718254011133 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 718254011134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718254011135 putative metal binding site [ion binding]; other site 718254011136 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 718254011137 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 718254011138 Ligand Binding Site [chemical binding]; other site 718254011139 TilS substrate binding domain; Region: TilS; pfam09179 718254011140 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 718254011141 Rho-binding antiterminator; Provisional; Region: PRK11625 718254011142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 718254011143 hypothetical protein; Provisional; Region: PRK09256 718254011144 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 718254011145 prolyl-tRNA synthetase; Provisional; Region: PRK09194 718254011146 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 718254011147 dimer interface [polypeptide binding]; other site 718254011148 motif 1; other site 718254011149 active site 718254011150 motif 2; other site 718254011151 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 718254011152 putative deacylase active site [active] 718254011153 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718254011154 active site 718254011155 motif 3; other site 718254011156 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 718254011157 anticodon binding site; other site 718254011158 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 718254011159 homodimer interaction site [polypeptide binding]; other site 718254011160 cofactor binding site; other site 718254011161 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 718254011162 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 718254011163 lipoprotein, YaeC family; Region: TIGR00363 718254011164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718254011165 dimer interface [polypeptide binding]; other site 718254011166 conserved gate region; other site 718254011167 ABC-ATPase subunit interface; other site 718254011168 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 718254011169 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 718254011170 Walker A/P-loop; other site 718254011171 ATP binding site [chemical binding]; other site 718254011172 Q-loop/lid; other site 718254011173 ABC transporter signature motif; other site 718254011174 Walker B; other site 718254011175 D-loop; other site 718254011176 H-loop/switch region; other site 718254011177 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 718254011178 potassium transporter; Provisional; Region: PRK10750 718254011179 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 718254011180 hypothetical protein; Provisional; Region: PRK11568 718254011181 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 718254011182 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 718254011183 proline dipeptidase; Provisional; Region: PRK13607 718254011184 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 718254011185 active site 718254011186 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 718254011187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 718254011188 substrate binding site [chemical binding]; other site 718254011189 oxyanion hole (OAH) forming residues; other site 718254011190 trimer interface [polypeptide binding]; other site 718254011191 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 718254011192 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 718254011193 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 718254011194 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 718254011195 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 718254011196 dimer interface [polypeptide binding]; other site 718254011197 active site 718254011198 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 718254011199 DALR anticodon binding domain; Region: DALR_1; pfam05746 718254011200 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 718254011201 dimer interface [polypeptide binding]; other site 718254011202 motif 1; other site 718254011203 active site 718254011204 motif 2; other site 718254011205 motif 3; other site 718254011206 YsaB-like lipoprotein; Region: YsaB; pfam13983 718254011207 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 718254011208 Acyltransferase family; Region: Acyl_transf_3; pfam01757 718254011209 xylulokinase; Provisional; Region: PRK15027 718254011210 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 718254011211 N- and C-terminal domain interface [polypeptide binding]; other site 718254011212 active site 718254011213 MgATP binding site [chemical binding]; other site 718254011214 catalytic site [active] 718254011215 metal binding site [ion binding]; metal-binding site 718254011216 xylulose binding site [chemical binding]; other site 718254011217 homodimer interface [polypeptide binding]; other site 718254011218 xylose isomerase; Provisional; Region: PRK05474 718254011219 xylose isomerase; Region: xylose_isom_A; TIGR02630 718254011220 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 718254011221 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 718254011222 putative ligand binding site [chemical binding]; other site 718254011223 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 718254011224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718254011225 Walker A/P-loop; other site 718254011226 ATP binding site [chemical binding]; other site 718254011227 Q-loop/lid; other site 718254011228 ABC transporter signature motif; other site 718254011229 Walker B; other site 718254011230 D-loop; other site 718254011231 H-loop/switch region; other site 718254011232 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718254011233 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718254011234 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718254011235 TM-ABC transporter signature motif; other site 718254011236 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 718254011237 putative dimerization interface [polypeptide binding]; other site 718254011238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718254011239 putative ligand binding site [chemical binding]; other site 718254011240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254011241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718254011242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718254011243 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 718254011244 hypothetical protein; Provisional; Region: PRK10356 718254011245 alpha-amylase; Reviewed; Region: malS; PRK09505 718254011246 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 718254011247 active site 718254011248 catalytic site [active] 718254011249 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 718254011250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718254011251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254011252 homodimer interface [polypeptide binding]; other site 718254011253 catalytic residue [active] 718254011254 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 718254011255 Transcriptional regulator [Transcription]; Region: IclR; COG1414 718254011256 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 718254011257 Bacterial transcriptional regulator; Region: IclR; pfam01614 718254011258 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 718254011259 Domain of unknown function (DUF386); Region: DUF386; pfam04074 718254011260 D-galactonate transporter; Region: 2A0114; TIGR00893 718254011261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254011262 putative substrate translocation pore; other site 718254011263 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 718254011264 putative N- and C-terminal domain interface [polypeptide binding]; other site 718254011265 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 718254011266 putative active site [active] 718254011267 MgATP binding site [chemical binding]; other site 718254011268 catalytic site [active] 718254011269 metal binding site [ion binding]; metal-binding site 718254011270 putative xylulose binding site [chemical binding]; other site 718254011271 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 718254011272 active site 718254011273 dimer interface [polypeptide binding]; other site 718254011274 magnesium binding site [ion binding]; other site 718254011275 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 718254011276 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 718254011277 AP (apurinic/apyrimidinic) site pocket; other site 718254011278 DNA interaction; other site 718254011279 Metal-binding active site; metal-binding site 718254011280 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 718254011281 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 718254011282 intersubunit interface [polypeptide binding]; other site 718254011283 active site 718254011284 Zn2+ binding site [ion binding]; other site 718254011285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 718254011286 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 718254011287 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 718254011288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718254011289 nucleotide binding site [chemical binding]; other site 718254011290 selenocysteine synthase; Provisional; Region: PRK04311 718254011291 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 718254011292 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 718254011293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718254011294 catalytic residue [active] 718254011295 putative glutathione S-transferase; Provisional; Region: PRK10357 718254011296 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 718254011297 putative C-terminal domain interface [polypeptide binding]; other site 718254011298 putative GSH binding site (G-site) [chemical binding]; other site 718254011299 putative dimer interface [polypeptide binding]; other site 718254011300 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 718254011301 dimer interface [polypeptide binding]; other site 718254011302 N-terminal domain interface [polypeptide binding]; other site 718254011303 putative substrate binding pocket (H-site) [chemical binding]; other site 718254011304 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 718254011305 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 718254011306 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 718254011307 active site 718254011308 P-loop; other site 718254011309 phosphorylation site [posttranslational modification] 718254011310 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718254011311 active site 718254011312 phosphorylation site [posttranslational modification] 718254011313 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 718254011314 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 718254011315 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 718254011316 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 718254011317 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 718254011318 hypothetical protein; Provisional; Region: PRK11020 718254011319 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718254011320 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718254011321 PapC N-terminal domain; Region: PapC_N; pfam13954 718254011322 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718254011323 PapC C-terminal domain; Region: PapC_C; pfam13953 718254011324 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718254011325 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718254011326 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718254011327 Fimbrial protein; Region: Fimbrial; cl01416 718254011328 L-lactate permease; Provisional; Region: PRK10420 718254011329 glycolate transporter; Provisional; Region: PRK09695 718254011330 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 718254011331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718254011332 DNA-binding site [nucleotide binding]; DNA binding site 718254011333 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718254011334 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 718254011335 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 718254011336 active site 718254011337 substrate binding site [chemical binding]; other site 718254011338 FMN binding site [chemical binding]; other site 718254011339 putative catalytic residues [active] 718254011340 benzoate transport; Region: 2A0115; TIGR00895 718254011341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254011342 putative substrate translocation pore; other site 718254011343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718254011344 putative rRNA methylase; Provisional; Region: PRK10358 718254011345 ketol-acid reductoisomerase; Validated; Region: PRK05225 718254011346 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 718254011347 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 718254011348 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 718254011349 threonine dehydratase; Reviewed; Region: PRK09224 718254011350 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 718254011351 tetramer interface [polypeptide binding]; other site 718254011352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718254011353 catalytic residue [active] 718254011354 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 718254011355 putative Ile/Val binding site [chemical binding]; other site 718254011356 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 718254011357 putative Ile/Val binding site [chemical binding]; other site 718254011358 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 718254011359 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 718254011360 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 718254011361 homodimer interface [polypeptide binding]; other site 718254011362 substrate-cofactor binding pocket; other site 718254011363 catalytic residue [active] 718254011364 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 718254011365 putative ATP-dependent protease; Provisional; Region: PRK09862 718254011366 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 718254011367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718254011368 Walker A motif; other site 718254011369 ATP binding site [chemical binding]; other site 718254011370 Walker B motif; other site 718254011371 arginine finger; other site 718254011372 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 718254011373 hypothetical protein; Provisional; Region: PRK11027