-- dump date 20140619_075353 -- class Genbank::misc_feature -- table misc_feature_note -- id note 215689000001 Transposase; Region: HTH_Tnp_1; cl17663 215689000002 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 215689000003 potential frameshift: common BLAST hit: gi|31790991|ref|NP_857628.1| putative ATP-binding ABC transporter 215689000004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 215689000005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689000006 ABC-ATPase subunit interface; other site 215689000007 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 215689000008 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 215689000009 Q-loop/lid; other site 215689000010 ABC transporter signature motif; other site 215689000011 Walker B; other site 215689000012 D-loop; other site 215689000013 H-loop/switch region; other site 215689000014 NIL domain; Region: NIL; pfam09383 215689000015 methionine sulfoxide reductase A; Provisional; Region: PRK14054 215689000016 autotransport protein MisL; Provisional; Region: PRK15313 215689000017 ParA-like protein; Provisional; Region: PHA02518 215689000018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 215689000019 P-loop; other site 215689000020 Magnesium ion binding site [ion binding]; other site 215689000021 ParG; Region: ParG; pfam09274 215689000022 Initiator Replication protein; Region: Rep_3; pfam01051 215689000023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689000024 MULE transposase domain; Region: MULE; pfam10551 215689000025 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 215689000026 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 215689000027 outer membrane protease; Reviewed; Region: PRK10993 215689000028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689000029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689000030 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 215689000031 putative dimerization interface [polypeptide binding]; other site 215689000032 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 215689000033 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 215689000034 NAD(P) binding site [chemical binding]; other site 215689000035 catalytic residues [active] 215689000036 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 215689000037 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 215689000038 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 215689000039 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689000040 dimer interface [polypeptide binding]; other site 215689000041 putative CheW interface [polypeptide binding]; other site 215689000042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689000043 non-specific DNA binding site [nucleotide binding]; other site 215689000044 salt bridge; other site 215689000045 sequence-specific DNA binding site [nucleotide binding]; other site 215689000046 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 215689000047 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 215689000048 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 215689000049 primosomal protein DnaI; Provisional; Region: PRK02854 215689000050 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 215689000051 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 215689000052 ATP binding site [chemical binding]; other site 215689000053 substrate interface [chemical binding]; other site 215689000054 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 215689000055 active site residue [active] 215689000056 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 215689000057 ThiS interaction site; other site 215689000058 putative active site [active] 215689000059 tetramer interface [polypeptide binding]; other site 215689000060 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 215689000061 thiS-thiF/thiG interaction site; other site 215689000062 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 215689000063 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 215689000064 multiple promoter invertase; Provisional; Region: mpi; PRK13413 215689000065 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 215689000066 catalytic residues [active] 215689000067 catalytic nucleophile [active] 215689000068 Presynaptic Site I dimer interface [polypeptide binding]; other site 215689000069 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 215689000070 Synaptic Flat tetramer interface [polypeptide binding]; other site 215689000071 Synaptic Site I dimer interface [polypeptide binding]; other site 215689000072 DNA binding site [nucleotide binding] 215689000073 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 215689000074 DNA-binding interface [nucleotide binding]; DNA binding site 215689000075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689000076 S-adenosylmethionine binding site [chemical binding]; other site 215689000077 choline transport protein BetT; Provisional; Region: PRK09928 215689000078 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 215689000079 Integrase core domain; Region: rve; pfam00665 215689000080 Integrase core domain; Region: rve_2; pfam13333 215689000081 DNA replication initiation factor; Provisional; Region: PRK08084 215689000082 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 215689000083 uracil transporter; Provisional; Region: PRK10720 215689000084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689000085 active site 215689000086 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 215689000087 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 215689000088 dimerization interface [polypeptide binding]; other site 215689000089 putative ATP binding site [chemical binding]; other site 215689000090 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 215689000091 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 215689000092 active site 215689000093 substrate binding site [chemical binding]; other site 215689000094 cosubstrate binding site; other site 215689000095 catalytic site [active] 215689000096 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 215689000097 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 215689000098 Walker A/P-loop; other site 215689000099 ATP binding site [chemical binding]; other site 215689000100 Q-loop/lid; other site 215689000101 ABC transporter signature motif; other site 215689000102 Walker B; other site 215689000103 D-loop; other site 215689000104 H-loop/switch region; other site 215689000105 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 215689000106 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 215689000107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689000108 dimer interface [polypeptide binding]; other site 215689000109 conserved gate region; other site 215689000110 putative PBP binding loops; other site 215689000111 ABC-ATPase subunit interface; other site 215689000112 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 215689000113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689000114 conserved gate region; other site 215689000115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689000116 dimer interface [polypeptide binding]; other site 215689000117 conserved gate region; other site 215689000118 putative PBP binding loops; other site 215689000119 ABC-ATPase subunit interface; other site 215689000120 polyphosphate kinase; Provisional; Region: PRK05443 215689000121 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 215689000122 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 215689000123 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 215689000124 putative active site [active] 215689000125 catalytic site [active] 215689000126 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 215689000127 domain interface [polypeptide binding]; other site 215689000128 active site 215689000129 catalytic site [active] 215689000130 exopolyphosphatase; Provisional; Region: PRK10854 215689000131 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 215689000132 nucleotide binding site [chemical binding]; other site 215689000133 tellurite resistance protein TehB; Provisional; Region: PRK11207 215689000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689000135 S-adenosylmethionine binding site [chemical binding]; other site 215689000136 MASE1; Region: MASE1; cl17823 215689000137 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 215689000138 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 215689000139 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 215689000140 MgtE intracellular N domain; Region: MgtE_N; smart00924 215689000141 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 215689000142 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 215689000143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689000144 putative substrate translocation pore; other site 215689000145 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 215689000146 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 215689000147 putative NAD(P) binding site [chemical binding]; other site 215689000148 active site 215689000149 putative substrate binding site [chemical binding]; other site 215689000150 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 215689000151 DNA-binding site [nucleotide binding]; DNA binding site 215689000152 RNA-binding motif; other site 215689000153 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 215689000154 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 215689000155 active site 215689000156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 215689000157 AAA domain; Region: AAA_13; pfam13166 215689000158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689000159 Walker A/P-loop; other site 215689000160 ATP binding site [chemical binding]; other site 215689000161 ABC transporter signature motif; other site 215689000162 Walker B; other site 215689000163 D-loop; other site 215689000164 H-loop/switch region; other site 215689000165 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 215689000166 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 215689000167 oligomeric interface; other site 215689000168 putative active site [active] 215689000169 homodimer interface [polypeptide binding]; other site 215689000170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689000171 DDE superfamily endonuclease; Region: DDE_3; pfam13358 215689000172 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 215689000173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689000174 putative substrate translocation pore; other site 215689000175 HTH-like domain; Region: HTH_21; pfam13276 215689000176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689000177 Transposase; Region: HTH_Tnp_1; pfam01527 215689000178 Predicted ATPase [General function prediction only]; Region: COG5293 215689000179 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 215689000180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689000181 sequence-specific DNA binding site [nucleotide binding]; other site 215689000182 salt bridge; other site 215689000183 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 215689000184 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 215689000185 GMP synthase; Reviewed; Region: guaA; PRK00074 215689000186 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 215689000187 AMP/PPi binding site [chemical binding]; other site 215689000188 candidate oxyanion hole; other site 215689000189 catalytic triad [active] 215689000190 potential glutamine specificity residues [chemical binding]; other site 215689000191 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 215689000192 ATP Binding subdomain [chemical binding]; other site 215689000193 Ligand Binding sites [chemical binding]; other site 215689000194 Dimerization subdomain; other site 215689000195 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 215689000196 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 215689000197 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 215689000198 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 215689000199 active site 215689000200 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 215689000201 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 215689000202 generic binding surface II; other site 215689000203 generic binding surface I; other site 215689000204 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 215689000205 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 215689000206 active site 215689000207 Zn binding site [ion binding]; other site 215689000208 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 215689000209 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 215689000210 Trp docking motif [polypeptide binding]; other site 215689000211 putative active site [active] 215689000212 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 215689000213 GTP-binding protein Der; Reviewed; Region: PRK00093 215689000214 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 215689000215 G1 box; other site 215689000216 GTP/Mg2+ binding site [chemical binding]; other site 215689000217 Switch I region; other site 215689000218 G2 box; other site 215689000219 Switch II region; other site 215689000220 G3 box; other site 215689000221 G4 box; other site 215689000222 G5 box; other site 215689000223 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 215689000224 G1 box; other site 215689000225 GTP/Mg2+ binding site [chemical binding]; other site 215689000226 Switch I region; other site 215689000227 G2 box; other site 215689000228 G3 box; other site 215689000229 Switch II region; other site 215689000230 G4 box; other site 215689000231 G5 box; other site 215689000232 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 215689000233 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 215689000234 Trp docking motif [polypeptide binding]; other site 215689000235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 215689000236 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 215689000237 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 215689000238 dimer interface [polypeptide binding]; other site 215689000239 motif 1; other site 215689000240 active site 215689000241 motif 2; other site 215689000242 motif 3; other site 215689000243 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 215689000244 anticodon binding site; other site 215689000245 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 215689000246 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 215689000247 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 215689000248 cytoskeletal protein RodZ; Provisional; Region: PRK10856 215689000249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689000250 non-specific DNA binding site [nucleotide binding]; other site 215689000251 salt bridge; other site 215689000252 sequence-specific DNA binding site [nucleotide binding]; other site 215689000253 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 215689000254 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 215689000255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 215689000256 binding surface 215689000257 TPR motif; other site 215689000258 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 215689000259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689000260 FeS/SAM binding site; other site 215689000261 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 215689000262 active site 215689000263 multimer interface [polypeptide binding]; other site 215689000264 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 215689000265 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 215689000266 active site residue [active] 215689000267 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 215689000268 active site residue [active] 215689000269 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 215689000270 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 215689000271 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 215689000272 dimer interface [polypeptide binding]; other site 215689000273 NADP binding site [chemical binding]; other site 215689000274 catalytic residues [active] 215689000275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 215689000276 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 215689000277 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 215689000278 Proline racemase; Region: Pro_racemase; pfam05544 215689000279 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 215689000280 Transcriptional regulators [Transcription]; Region: GntR; COG1802 215689000281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689000282 DNA-binding site [nucleotide binding]; DNA binding site 215689000283 FCD domain; Region: FCD; pfam07729 215689000284 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 215689000285 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 215689000286 inhibitor site; inhibition site 215689000287 active site 215689000288 dimer interface [polypeptide binding]; other site 215689000289 catalytic residue [active] 215689000290 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 215689000291 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 215689000292 aminopeptidase B; Provisional; Region: PRK05015 215689000293 Peptidase; Region: DUF3663; pfam12404 215689000294 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 215689000295 interface (dimer of trimers) [polypeptide binding]; other site 215689000296 Substrate-binding/catalytic site; other site 215689000297 Zn-binding sites [ion binding]; other site 215689000298 cysteine desulfurase; Provisional; Region: PRK14012 215689000299 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 215689000300 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689000301 catalytic residue [active] 215689000302 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 215689000303 Rrf2 family protein; Region: rrf2_super; TIGR00738 215689000304 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 215689000305 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 215689000306 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 215689000307 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 215689000308 active site 215689000309 dimerization interface [polypeptide binding]; other site 215689000310 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 215689000311 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 215689000312 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 215689000313 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 215689000314 PRD domain; Region: PRD; pfam00874 215689000315 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 215689000316 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 215689000317 dimer interface [polypeptide binding]; other site 215689000318 active site 215689000319 glycine-pyridoxal phosphate binding site [chemical binding]; other site 215689000320 folate binding site [chemical binding]; other site 215689000321 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 215689000322 Nitrogen regulatory protein P-II; Region: P-II; smart00938 215689000323 response regulator GlrR; Provisional; Region: PRK15115 215689000324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689000325 active site 215689000326 phosphorylation site [posttranslational modification] 215689000327 intermolecular recognition site; other site 215689000328 dimerization interface [polypeptide binding]; other site 215689000329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689000330 Walker A motif; other site 215689000331 ATP binding site [chemical binding]; other site 215689000332 Walker B motif; other site 215689000333 arginine finger; other site 215689000334 hypothetical protein; Provisional; Region: PRK10722 215689000335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 215689000336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 215689000337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689000338 dimer interface [polypeptide binding]; other site 215689000339 phosphorylation site [posttranslational modification] 215689000340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689000341 ATP binding site [chemical binding]; other site 215689000342 Mg2+ binding site [ion binding]; other site 215689000343 G-X-G motif; other site 215689000344 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 215689000345 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 215689000346 dimerization interface [polypeptide binding]; other site 215689000347 ATP binding site [chemical binding]; other site 215689000348 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 215689000349 dimerization interface [polypeptide binding]; other site 215689000350 ATP binding site [chemical binding]; other site 215689000351 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 215689000352 putative active site [active] 215689000353 catalytic triad [active] 215689000354 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 215689000355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689000356 substrate binding pocket [chemical binding]; other site 215689000357 membrane-bound complex binding site; other site 215689000358 hinge residues; other site 215689000359 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689000360 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689000361 catalytic residue [active] 215689000362 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 215689000363 nucleoside/Zn binding site; other site 215689000364 dimer interface [polypeptide binding]; other site 215689000365 catalytic motif [active] 215689000366 hypothetical protein; Provisional; Region: PRK11590 215689000367 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 215689000368 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 215689000369 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 215689000370 putative active site [active] 215689000371 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 215689000372 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 215689000373 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 215689000374 putative active site [active] 215689000375 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 215689000376 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 215689000377 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 215689000378 active site 215689000379 hydrophilic channel; other site 215689000380 dimerization interface [polypeptide binding]; other site 215689000381 catalytic residues [active] 215689000382 active site lid [active] 215689000383 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 215689000384 Recombination protein O N terminal; Region: RecO_N; pfam11967 215689000385 Recombination protein O C terminal; Region: RecO_C; pfam02565 215689000386 GTPase Era; Reviewed; Region: era; PRK00089 215689000387 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 215689000388 G1 box; other site 215689000389 GTP/Mg2+ binding site [chemical binding]; other site 215689000390 Switch I region; other site 215689000391 G2 box; other site 215689000392 Switch II region; other site 215689000393 G3 box; other site 215689000394 G4 box; other site 215689000395 G5 box; other site 215689000396 KH domain; Region: KH_2; pfam07650 215689000397 ribonuclease III; Reviewed; Region: rnc; PRK00102 215689000398 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 215689000399 dimerization interface [polypeptide binding]; other site 215689000400 active site 215689000401 metal binding site [ion binding]; metal-binding site 215689000402 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 215689000403 dsRNA binding site [nucleotide binding]; other site 215689000404 signal peptidase I; Provisional; Region: PRK10861 215689000405 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 215689000406 Catalytic site [active] 215689000407 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 215689000408 GTP-binding protein LepA; Provisional; Region: PRK05433 215689000409 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 215689000410 G1 box; other site 215689000411 putative GEF interaction site [polypeptide binding]; other site 215689000412 GTP/Mg2+ binding site [chemical binding]; other site 215689000413 Switch I region; other site 215689000414 G2 box; other site 215689000415 G3 box; other site 215689000416 Switch II region; other site 215689000417 G4 box; other site 215689000418 G5 box; other site 215689000419 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 215689000420 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 215689000421 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 215689000422 Antitermination protein; Region: Antiterm; pfam03589 215689000423 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 215689000424 SoxR reducing system protein RseC; Provisional; Region: PRK10862 215689000425 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 215689000426 anti-sigma E factor; Provisional; Region: rseB; PRK09455 215689000427 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 215689000428 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 215689000429 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 215689000430 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 215689000431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689000432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689000433 DNA binding residues [nucleotide binding] 215689000434 L-aspartate oxidase; Provisional; Region: PRK09077 215689000435 L-aspartate oxidase; Provisional; Region: PRK06175 215689000436 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 215689000437 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 215689000438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689000439 S-adenosylmethionine binding site [chemical binding]; other site 215689000440 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 215689000441 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 215689000442 ATP binding site [chemical binding]; other site 215689000443 Mg++ binding site [ion binding]; other site 215689000444 motif III; other site 215689000445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689000446 nucleotide binding region [chemical binding]; other site 215689000447 ATP-binding site [chemical binding]; other site 215689000448 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 215689000449 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 215689000450 ligand binding site [chemical binding]; other site 215689000451 active site 215689000452 UGI interface [polypeptide binding]; other site 215689000453 catalytic site [active] 215689000454 GrpE; Region: GrpE; pfam01025 215689000455 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 215689000456 dimer interface [polypeptide binding]; other site 215689000457 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 215689000458 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 215689000459 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 215689000460 recombination and repair protein; Provisional; Region: PRK10869 215689000461 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 215689000462 Walker A/P-loop; other site 215689000463 ATP binding site [chemical binding]; other site 215689000464 Q-loop/lid; other site 215689000465 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 215689000466 ABC transporter signature motif; other site 215689000467 Walker B; other site 215689000468 D-loop; other site 215689000469 H-loop/switch region; other site 215689000470 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 215689000471 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 215689000472 hypothetical protein; Validated; Region: PRK01777 215689000473 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 215689000474 putative coenzyme Q binding site [chemical binding]; other site 215689000475 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 215689000476 SmpB-tmRNA interface; other site 215689000477 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 215689000478 active site 215689000479 Int/Topo IB signature motif; other site 215689000480 potential frameshift: common BLAST hit: gi|259908680|ref|YP_002649036.1| integrase catalytic subunit 215689000481 Integrase core domain; Region: rve; pfam00665 215689000482 Integrase core domain; Region: rve_3; pfam13683 215689000483 HTH-like domain; Region: HTH_21; pfam13276 215689000484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689000485 Transposase; Region: HTH_Tnp_1; pfam01527 215689000486 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 215689000487 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 215689000488 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 215689000489 putative CheA interaction surface; other site 215689000490 chemotaxis protein CheA; Provisional; Region: PRK10547 215689000491 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 215689000492 putative binding surface; other site 215689000493 active site 215689000494 CheY binding; Region: CheY-binding; pfam09078 215689000495 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 215689000496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689000497 ATP binding site [chemical binding]; other site 215689000498 Mg2+ binding site [ion binding]; other site 215689000499 G-X-G motif; other site 215689000500 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 215689000501 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 215689000502 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 215689000503 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 215689000504 ligand binding site [chemical binding]; other site 215689000505 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 215689000506 flagellar motor protein MotA; Validated; Region: PRK09110 215689000507 transcriptional activator FlhC; Provisional; Region: PRK12722 215689000508 transcriptional activator FlhD; Provisional; Region: PRK02909 215689000509 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 215689000510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689000511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 215689000512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689000513 DNA binding residues [nucleotide binding] 215689000514 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 215689000515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689000516 dimerization interface [polypeptide binding]; other site 215689000517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689000518 dimer interface [polypeptide binding]; other site 215689000519 putative CheW interface [polypeptide binding]; other site 215689000520 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 215689000521 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 215689000522 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 215689000523 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689000524 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 215689000525 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 215689000526 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 215689000527 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 215689000528 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 215689000529 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 215689000530 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 215689000531 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 215689000532 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 215689000533 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689000534 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 215689000535 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 215689000536 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 215689000537 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 215689000538 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 215689000539 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689000540 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 215689000541 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 215689000542 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 215689000543 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 215689000544 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689000545 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 215689000546 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 215689000547 SAF-like; Region: SAF_2; pfam13144 215689000548 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 215689000549 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 215689000550 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 215689000551 FlgN protein; Region: FlgN; cl09176 215689000552 Flagellar protein FliS; Region: FliS; cl00654 215689000553 flagellar capping protein; Reviewed; Region: fliD; PRK08032 215689000554 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 215689000555 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 215689000556 flagellin; Validated; Region: PRK08026 215689000557 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 215689000558 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 215689000559 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 215689000560 DNA binding site [nucleotide binding] 215689000561 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 215689000562 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 215689000563 putative trimer interface [polypeptide binding]; other site 215689000564 putative CoA binding site [chemical binding]; other site 215689000565 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 215689000566 trimer interface [polypeptide binding]; other site 215689000567 active site 215689000568 substrate binding site [chemical binding]; other site 215689000569 CoA binding site [chemical binding]; other site 215689000570 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 215689000571 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 215689000572 inhibitor-cofactor binding pocket; inhibition site 215689000573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689000574 catalytic residue [active] 215689000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689000576 S-adenosylmethionine binding site [chemical binding]; other site 215689000577 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 215689000578 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 215689000579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 215689000580 TPR motif; other site 215689000581 binding surface 215689000582 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 215689000583 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 215689000584 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 215689000585 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 215689000586 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 215689000587 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 215689000588 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 215689000589 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 215689000590 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 215689000591 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 215689000592 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 215689000593 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 215689000594 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 215689000595 Walker A motif/ATP binding site; other site 215689000596 Walker B motif; other site 215689000597 flagellar assembly protein H; Validated; Region: fliH; PRK05687 215689000598 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 215689000599 Flagellar assembly protein FliH; Region: FliH; pfam02108 215689000600 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 215689000601 FliG C-terminal domain; Region: FliG_C; pfam01706 215689000602 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 215689000603 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 215689000604 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 215689000605 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 215689000606 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 215689000607 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 215689000608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689000609 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 215689000610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689000611 active site 215689000612 phosphorylation site [posttranslational modification] 215689000613 intermolecular recognition site; other site 215689000614 dimerization interface [polypeptide binding]; other site 215689000615 CheB methylesterase; Region: CheB_methylest; pfam01339 215689000616 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 215689000617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689000618 active site 215689000619 phosphorylation site [posttranslational modification] 215689000620 intermolecular recognition site; other site 215689000621 dimerization interface [polypeptide binding]; other site 215689000622 chemotaxis regulator CheZ; Provisional; Region: PRK11166 215689000623 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 215689000624 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 215689000625 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 215689000626 FHIPEP family; Region: FHIPEP; pfam00771 215689000627 Flagellar protein FlhE; Region: FlhE; pfam06366 215689000628 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 215689000629 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 215689000630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689000631 Coenzyme A binding pocket [chemical binding]; other site 215689000632 hypothetical protein; Provisional; Region: PRK10556 215689000633 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 215689000634 catalytic residues [active] 215689000635 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 215689000636 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 215689000637 Class I ribonucleotide reductase; Region: RNR_I; cd01679 215689000638 active site 215689000639 dimer interface [polypeptide binding]; other site 215689000640 catalytic residues [active] 215689000641 effector binding site; other site 215689000642 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 215689000643 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 215689000644 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 215689000645 dimer interface [polypeptide binding]; other site 215689000646 putative radical transfer pathway; other site 215689000647 diiron center [ion binding]; other site 215689000648 tyrosyl radical; other site 215689000649 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 215689000650 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 215689000651 Walker A/P-loop; other site 215689000652 ATP binding site [chemical binding]; other site 215689000653 Q-loop/lid; other site 215689000654 ABC transporter signature motif; other site 215689000655 Walker B; other site 215689000656 D-loop; other site 215689000657 H-loop/switch region; other site 215689000658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 215689000659 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 215689000660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689000661 dimer interface [polypeptide binding]; other site 215689000662 conserved gate region; other site 215689000663 putative PBP binding loops; other site 215689000664 ABC-ATPase subunit interface; other site 215689000665 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 215689000666 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 215689000667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689000668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 215689000669 putative substrate translocation pore; other site 215689000670 transcriptional repressor MprA; Provisional; Region: PRK10870 215689000671 Transcriptional regulators [Transcription]; Region: MarR; COG1846 215689000672 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 215689000673 ATP P2X receptor; Region: P2X_receptor; cl02993 215689000674 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 215689000675 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689000676 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 215689000677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689000678 putative substrate translocation pore; other site 215689000679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689000680 putative methyltransferase; Provisional; Region: PRK10864 215689000681 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 215689000682 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 215689000683 thioredoxin 2; Provisional; Region: PRK10996 215689000684 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 215689000685 catalytic residues [active] 215689000686 Uncharacterized conserved protein [Function unknown]; Region: COG3148 215689000687 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 215689000688 CoA binding domain; Region: CoA_binding_2; pfam13380 215689000689 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 215689000690 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 215689000691 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 215689000692 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 215689000693 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 215689000694 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 215689000695 domain interface [polypeptide binding]; other site 215689000696 putative active site [active] 215689000697 catalytic site [active] 215689000698 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 215689000699 domain interface [polypeptide binding]; other site 215689000700 putative active site [active] 215689000701 catalytic site [active] 215689000702 lipoprotein; Provisional; Region: PRK10759 215689000703 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 215689000704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689000705 putative substrate translocation pore; other site 215689000706 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 215689000707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689000708 active site 215689000709 motif I; other site 215689000710 motif II; other site 215689000711 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 215689000712 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 215689000713 Walker A/P-loop; other site 215689000714 ATP binding site [chemical binding]; other site 215689000715 Q-loop/lid; other site 215689000716 ABC transporter signature motif; other site 215689000717 Walker B; other site 215689000718 D-loop; other site 215689000719 H-loop/switch region; other site 215689000720 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 215689000721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689000722 dimer interface [polypeptide binding]; other site 215689000723 conserved gate region; other site 215689000724 ABC-ATPase subunit interface; other site 215689000725 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 215689000726 lipoprotein, YaeC family; Region: TIGR00363 215689000727 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 215689000728 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 215689000729 homodimer interaction site [polypeptide binding]; other site 215689000730 cofactor binding site; other site 215689000731 prolyl-tRNA synthetase; Provisional; Region: PRK09194 215689000732 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 215689000733 dimer interface [polypeptide binding]; other site 215689000734 motif 1; other site 215689000735 active site 215689000736 motif 2; other site 215689000737 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 215689000738 putative deacylase active site [active] 215689000739 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 215689000740 active site 215689000741 motif 3; other site 215689000742 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 215689000743 anticodon binding site; other site 215689000744 hypothetical protein; Provisional; Region: PRK09256 215689000745 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 215689000746 YaeQ protein; Region: YaeQ; pfam07152 215689000747 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 215689000748 Cytochrome c; Region: Cytochrom_C; cl11414 215689000749 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 215689000750 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 215689000751 Ligand Binding Site [chemical binding]; other site 215689000752 TilS substrate binding domain; Region: TilS; pfam09179 215689000753 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 215689000754 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 215689000755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 215689000756 putative metal binding site [ion binding]; other site 215689000757 lysine decarboxylase LdcC; Provisional; Region: PRK15399 215689000758 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 215689000759 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 215689000760 homodimer interface [polypeptide binding]; other site 215689000761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689000762 catalytic residue [active] 215689000763 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 215689000764 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 215689000765 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 215689000766 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 215689000767 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 215689000768 putative active site [active] 215689000769 putative PHP Thumb interface [polypeptide binding]; other site 215689000770 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 215689000771 generic binding surface II; other site 215689000772 generic binding surface I; other site 215689000773 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 215689000774 RNA/DNA hybrid binding site [nucleotide binding]; other site 215689000775 active site 215689000776 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 215689000777 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 215689000778 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 215689000779 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 215689000780 active site 215689000781 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 215689000782 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 215689000783 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 215689000784 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 215689000785 trimer interface [polypeptide binding]; other site 215689000786 active site 215689000787 UDP-GlcNAc binding site [chemical binding]; other site 215689000788 lipid binding site [chemical binding]; lipid-binding site 215689000789 periplasmic chaperone; Provisional; Region: PRK10780 215689000790 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 215689000791 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 215689000792 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 215689000793 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 215689000794 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 215689000795 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 215689000796 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 215689000797 Surface antigen; Region: Bac_surface_Ag; pfam01103 215689000798 zinc metallopeptidase RseP; Provisional; Region: PRK10779 215689000799 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 215689000800 active site 215689000801 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 215689000802 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 215689000803 protein binding site [polypeptide binding]; other site 215689000804 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 215689000805 putative substrate binding region [chemical binding]; other site 215689000806 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 215689000807 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 215689000808 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 215689000809 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 215689000810 catalytic residue [active] 215689000811 putative FPP diphosphate binding site; other site 215689000812 putative FPP binding hydrophobic cleft; other site 215689000813 dimer interface [polypeptide binding]; other site 215689000814 putative IPP diphosphate binding site; other site 215689000815 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 215689000816 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 215689000817 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 215689000818 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 215689000819 ribosome recycling factor; Reviewed; Region: frr; PRK00083 215689000820 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 215689000821 hinge region; other site 215689000822 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 215689000823 putative nucleotide binding site [chemical binding]; other site 215689000824 uridine monophosphate binding site [chemical binding]; other site 215689000825 homohexameric interface [polypeptide binding]; other site 215689000826 elongation factor Ts; Provisional; Region: tsf; PRK09377 215689000827 UBA/TS-N domain; Region: UBA; pfam00627 215689000828 Elongation factor TS; Region: EF_TS; pfam00889 215689000829 Elongation factor TS; Region: EF_TS; pfam00889 215689000830 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 215689000831 rRNA interaction site [nucleotide binding]; other site 215689000832 S8 interaction site; other site 215689000833 putative laminin-1 binding site; other site 215689000834 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 215689000835 active site 215689000836 PII uridylyl-transferase; Provisional; Region: PRK05007 215689000837 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 215689000838 metal binding triad; other site 215689000839 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 215689000840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 215689000841 Zn2+ binding site [ion binding]; other site 215689000842 Mg2+ binding site [ion binding]; other site 215689000843 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 215689000844 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 215689000845 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 215689000846 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 215689000847 trimer interface [polypeptide binding]; other site 215689000848 active site 215689000849 substrate binding site [chemical binding]; other site 215689000850 CoA binding site [chemical binding]; other site 215689000851 hypothetical protein; Provisional; Region: PRK13677 215689000852 serine endoprotease; Provisional; Region: PRK10942 215689000853 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 215689000854 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 215689000855 protein binding site [polypeptide binding]; other site 215689000856 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 215689000857 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 215689000858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 215689000859 Zn2+ binding site [ion binding]; other site 215689000860 Mg2+ binding site [ion binding]; other site 215689000861 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 215689000862 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 215689000863 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 215689000864 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 215689000865 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 215689000866 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 215689000867 inhibitor-cofactor binding pocket; inhibition site 215689000868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689000869 catalytic residue [active] 215689000870 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 215689000871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 215689000872 ABC-ATPase subunit interface; other site 215689000873 dimer interface [polypeptide binding]; other site 215689000874 putative PBP binding regions; other site 215689000875 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 215689000876 ABC-ATPase subunit interface; other site 215689000877 dimer interface [polypeptide binding]; other site 215689000878 putative PBP binding regions; other site 215689000879 iron-hydroxamate transporter substrate-binding subunit; Provisional; Region: PRK10576 215689000880 intersubunit interface [polypeptide binding]; other site 215689000881 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 215689000882 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 215689000883 Walker A/P-loop; other site 215689000884 ATP binding site [chemical binding]; other site 215689000885 Q-loop/lid; other site 215689000886 ABC transporter signature motif; other site 215689000887 Walker B; other site 215689000888 D-loop; other site 215689000889 H-loop/switch region; other site 215689000890 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 215689000891 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 215689000892 N-terminal plug; other site 215689000893 ligand-binding site [chemical binding]; other site 215689000894 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689000895 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689000896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689000897 active site 215689000898 DNA binding site [nucleotide binding] 215689000899 Int/Topo IB signature motif; other site 215689000900 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689000901 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689000902 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 215689000903 active site 215689000904 metal binding site [ion binding]; metal-binding site 215689000905 interdomain interaction site; other site 215689000906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689000907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689000908 non-specific DNA binding site [nucleotide binding]; other site 215689000909 salt bridge; other site 215689000910 sequence-specific DNA binding site [nucleotide binding]; other site 215689000911 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689000912 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689000913 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 215689000914 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689000915 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689000916 active site 215689000917 DNA binding site [nucleotide binding] 215689000918 Int/Topo IB signature motif; other site 215689000919 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689000920 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689000921 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 215689000922 active site 215689000923 metal binding site [ion binding]; metal-binding site 215689000924 interdomain interaction site; other site 215689000925 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689000926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689000927 non-specific DNA binding site [nucleotide binding]; other site 215689000928 salt bridge; other site 215689000929 sequence-specific DNA binding site [nucleotide binding]; other site 215689000930 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689000931 potential frameshift: common BLAST hit: gi|259909768|ref|YP_002650124.1| Rhs family protein 215689000932 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 215689000933 RHS Repeat; Region: RHS_repeat; pfam05593 215689000934 RHS Repeat; Region: RHS_repeat; cl11982 215689000935 RHS Repeat; Region: RHS_repeat; cl11982 215689000936 RHS protein; Region: RHS; pfam03527 215689000937 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689000938 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 215689000939 PAAR motif; Region: PAAR_motif; pfam05488 215689000940 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 215689000941 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 215689000942 Transglycosylase; Region: Transgly; pfam00912 215689000943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 215689000944 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 215689000945 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689000946 ATP binding site [chemical binding]; other site 215689000947 putative Mg++ binding site [ion binding]; other site 215689000948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689000949 nucleotide binding region [chemical binding]; other site 215689000950 ATP-binding site [chemical binding]; other site 215689000951 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 215689000952 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 215689000953 2'-5' RNA ligase; Provisional; Region: PRK15124 215689000954 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 215689000955 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 215689000956 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 215689000957 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 215689000958 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 215689000959 active site 215689000960 HIGH motif; other site 215689000961 nucleotide binding site [chemical binding]; other site 215689000962 KMSKS motif; other site 215689000963 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 215689000964 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 215689000965 active site 215689000966 NTP binding site [chemical binding]; other site 215689000967 metal binding triad [ion binding]; metal-binding site 215689000968 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 215689000969 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 215689000970 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 215689000971 catalytic center binding site [active] 215689000972 ATP binding site [chemical binding]; other site 215689000973 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 215689000974 oligomerization interface [polypeptide binding]; other site 215689000975 active site 215689000976 metal binding site [ion binding]; metal-binding site 215689000977 Pantoate-beta-alanine ligase; Region: PanC; cd00560 215689000978 pantoate--beta-alanine ligase; Region: panC; TIGR00018 215689000979 active site 215689000980 ATP-binding site [chemical binding]; other site 215689000981 pantoate-binding site; other site 215689000982 HXXH motif; other site 215689000983 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 215689000984 tetramerization interface [polypeptide binding]; other site 215689000985 active site 215689000986 inner membrane transport permease; Provisional; Region: PRK15066 215689000987 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 215689000988 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 215689000989 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 215689000990 Walker A/P-loop; other site 215689000991 ATP binding site [chemical binding]; other site 215689000992 Q-loop/lid; other site 215689000993 ABC transporter signature motif; other site 215689000994 Walker B; other site 215689000995 D-loop; other site 215689000996 H-loop/switch region; other site 215689000997 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 215689000998 active site clefts [active] 215689000999 zinc binding site [ion binding]; other site 215689001000 dimer interface [polypeptide binding]; other site 215689001001 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 215689001002 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689001003 active site 215689001004 methionine gamma-lyase; Validated; Region: PRK07049 215689001005 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 215689001006 homodimer interface [polypeptide binding]; other site 215689001007 substrate-cofactor binding pocket; other site 215689001008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689001009 catalytic residue [active] 215689001010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 215689001011 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689001012 DNA binding residues [nucleotide binding] 215689001013 dimerization interface [polypeptide binding]; other site 215689001014 multicopper oxidase; Provisional; Region: PRK10965 215689001015 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 215689001016 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 215689001017 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 215689001018 spermidine synthase; Provisional; Region: PRK00811 215689001019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689001020 S-adenosylmethionine binding site [chemical binding]; other site 215689001021 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 215689001022 hypothetical protein; Provisional; Region: PRK05248 215689001023 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 215689001024 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 215689001025 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 215689001026 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 215689001027 substrate binding site [chemical binding]; other site 215689001028 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 215689001029 substrate binding site [chemical binding]; other site 215689001030 ligand binding site [chemical binding]; other site 215689001031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 215689001032 DNA binding site [nucleotide binding] 215689001033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689001034 HTH-like domain; Region: HTH_21; pfam13276 215689001035 Integrase core domain; Region: rve; pfam00665 215689001036 Integrase core domain; Region: rve; pfam00665 215689001037 Integrase core domain; Region: rve_3; cl15866 215689001038 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 215689001039 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 215689001040 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 215689001041 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 215689001042 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 215689001043 CT1975-like protein; Region: Cas_CT1975; pfam09344 215689001044 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 215689001045 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 215689001046 helicase Cas3; Provisional; Region: PRK09694 215689001047 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 215689001048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 215689001049 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 215689001050 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 215689001051 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 215689001052 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 215689001053 substrate binding site [chemical binding]; other site 215689001054 oxyanion hole (OAH) forming residues; other site 215689001055 trimer interface [polypeptide binding]; other site 215689001056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 215689001057 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 215689001058 dimer interface [polypeptide binding]; other site 215689001059 active site 215689001060 acyl-CoA synthetase; Validated; Region: PRK07638 215689001061 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 215689001062 acyl-activating enzyme (AAE) consensus motif; other site 215689001063 AMP binding site [chemical binding]; other site 215689001064 active site 215689001065 CoA binding site [chemical binding]; other site 215689001066 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 215689001067 active site 215689001068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 215689001069 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 215689001070 NADP binding site [chemical binding]; other site 215689001071 dimer interface [polypeptide binding]; other site 215689001072 BioY family; Region: BioY; pfam02632 215689001073 Cobalt transport protein; Region: CbiQ; cl00463 215689001074 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 215689001075 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 215689001076 Walker A/P-loop; other site 215689001077 ATP binding site [chemical binding]; other site 215689001078 Q-loop/lid; other site 215689001079 ABC transporter signature motif; other site 215689001080 Walker B; other site 215689001081 D-loop; other site 215689001082 H-loop/switch region; other site 215689001083 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 215689001084 classical (c) SDRs; Region: SDR_c; cd05233 215689001085 NAD(P) binding site [chemical binding]; other site 215689001086 active site 215689001087 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 215689001088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 215689001089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 215689001090 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 215689001091 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 215689001092 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 215689001093 E3 interaction surface; other site 215689001094 lipoyl attachment site [posttranslational modification]; other site 215689001095 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 215689001096 E3 interaction surface; other site 215689001097 lipoyl attachment site [posttranslational modification]; other site 215689001098 e3 binding domain; Region: E3_binding; pfam02817 215689001099 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 215689001100 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 215689001101 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 215689001102 dimer interface [polypeptide binding]; other site 215689001103 TPP-binding site [chemical binding]; other site 215689001104 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 215689001105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689001106 DNA-binding site [nucleotide binding]; DNA binding site 215689001107 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 215689001108 aromatic amino acid transporter; Provisional; Region: PRK10238 215689001109 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 215689001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689001111 putative substrate translocation pore; other site 215689001112 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 215689001113 active site 215689001114 regulatory protein AmpE; Provisional; Region: PRK10987 215689001115 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 215689001116 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 215689001117 amidase catalytic site [active] 215689001118 Zn binding residues [ion binding]; other site 215689001119 substrate binding site [chemical binding]; other site 215689001120 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 215689001121 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 215689001122 dimerization interface [polypeptide binding]; other site 215689001123 active site 215689001124 putative major pilin subunit; Provisional; Region: PRK10574 215689001125 hypothetical protein; Provisional; Region: PRK10436 215689001126 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 215689001127 Walker A motif; other site 215689001128 ATP binding site [chemical binding]; other site 215689001129 Walker B motif; other site 215689001130 type IV pilin biogenesis protein; Provisional; Region: PRK10573 215689001131 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689001132 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689001133 potential frameshift: common BLAST hit: gi|292898449|ref|YP_003537818.1| GMP reductase 215689001134 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 215689001135 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 215689001136 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 215689001137 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 215689001138 CoA-binding site [chemical binding]; other site 215689001139 ATP-binding [chemical binding]; other site 215689001140 hypothetical protein; Provisional; Region: PRK05287 215689001141 DNA gyrase inhibitor; Reviewed; Region: PRK00418 215689001142 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 215689001143 active site 215689001144 8-oxo-dGMP binding site [chemical binding]; other site 215689001145 nudix motif; other site 215689001146 metal binding site [ion binding]; metal-binding site 215689001147 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 215689001148 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 215689001149 type II secretion system protein D; Region: type_II_gspD; TIGR02517 215689001150 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689001151 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689001152 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689001153 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 215689001154 type II secretion system protein E; Region: type_II_gspE; TIGR02533 215689001155 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 215689001156 Walker A motif; other site 215689001157 ATP binding site [chemical binding]; other site 215689001158 Walker B motif; other site 215689001159 type II secretion system protein F; Region: GspF; TIGR02120 215689001160 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689001161 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689001162 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 215689001163 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 215689001164 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 215689001165 type II secretion system protein I; Region: gspI; TIGR01707 215689001166 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 215689001167 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 215689001168 type II secretion system protein J; Region: gspJ; TIGR01711 215689001169 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 215689001170 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 215689001171 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 215689001172 GspL periplasmic domain; Region: GspL_C; cl14909 215689001173 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 215689001174 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 215689001175 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 215689001176 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 215689001177 Chitin binding domain; Region: Chitin_bind_3; pfam03067 215689001178 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 215689001179 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 215689001180 SEC-C motif; Region: SEC-C; pfam02810 215689001181 SecA regulator SecM; Provisional; Region: PRK02943 215689001182 Protein of unknown function (DUF721); Region: DUF721; cl02324 215689001183 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 215689001184 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 215689001185 cell division protein FtsZ; Validated; Region: PRK09330 215689001186 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 215689001187 nucleotide binding site [chemical binding]; other site 215689001188 SulA interaction site; other site 215689001189 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 215689001190 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 215689001191 Cell division protein FtsA; Region: FtsA; pfam14450 215689001192 cell division protein FtsQ; Provisional; Region: PRK10775 215689001193 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 215689001194 Cell division protein FtsQ; Region: FtsQ; pfam03799 215689001195 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 215689001196 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 215689001197 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 215689001198 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 215689001199 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 215689001200 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 215689001201 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 215689001202 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 215689001203 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 215689001204 active site 215689001205 homodimer interface [polypeptide binding]; other site 215689001206 cell division protein FtsW; Provisional; Region: PRK10774 215689001207 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 215689001208 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 215689001209 NAD(P) binding pocket [chemical binding]; other site 215689001210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 215689001211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 215689001212 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 215689001213 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 215689001214 Mg++ binding site [ion binding]; other site 215689001215 putative catalytic motif [active] 215689001216 putative substrate binding site [chemical binding]; other site 215689001217 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 215689001218 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 215689001219 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 215689001220 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 215689001221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 215689001222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 215689001223 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 215689001224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 215689001225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 215689001226 cell division protein FtsL; Provisional; Region: PRK10772 215689001227 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 215689001228 MraW methylase family; Region: Methyltransf_5; pfam01795 215689001229 cell division protein MraZ; Reviewed; Region: PRK00326 215689001230 MraZ protein; Region: MraZ; pfam02381 215689001231 MraZ protein; Region: MraZ; pfam02381 215689001232 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 215689001233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689001234 DNA binding site [nucleotide binding] 215689001235 domain linker motif; other site 215689001236 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 215689001237 dimerization interface [polypeptide binding]; other site 215689001238 ligand binding site [chemical binding]; other site 215689001239 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 215689001240 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 215689001241 putative valine binding site [chemical binding]; other site 215689001242 dimer interface [polypeptide binding]; other site 215689001243 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 215689001244 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 215689001245 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 215689001246 PYR/PP interface [polypeptide binding]; other site 215689001247 dimer interface [polypeptide binding]; other site 215689001248 TPP binding site [chemical binding]; other site 215689001249 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 215689001250 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 215689001251 TPP-binding site [chemical binding]; other site 215689001252 dimer interface [polypeptide binding]; other site 215689001253 2-isopropylmalate synthase; Validated; Region: PRK00915 215689001254 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 215689001255 active site 215689001256 catalytic residues [active] 215689001257 metal binding site [ion binding]; metal-binding site 215689001258 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 215689001259 tartrate dehydrogenase; Provisional; Region: PRK08194 215689001260 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 215689001261 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 215689001262 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 215689001263 substrate binding site [chemical binding]; other site 215689001264 ligand binding site [chemical binding]; other site 215689001265 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 215689001266 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 215689001267 substrate binding site [chemical binding]; other site 215689001268 potential frameshift: common BLAST hit: gi|292898400|ref|YP_003537769.1| sugar efflux transporter A 215689001269 sugar efflux transporter B; Provisional; Region: PRK15011 215689001270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689001271 transcriptional regulator SgrR; Provisional; Region: PRK13626 215689001272 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 215689001273 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 215689001274 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 215689001275 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 215689001276 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 215689001277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689001278 dimer interface [polypeptide binding]; other site 215689001279 conserved gate region; other site 215689001280 putative PBP binding loops; other site 215689001281 ABC-ATPase subunit interface; other site 215689001282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689001283 dimer interface [polypeptide binding]; other site 215689001284 conserved gate region; other site 215689001285 putative PBP binding loops; other site 215689001286 ABC-ATPase subunit interface; other site 215689001287 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 215689001288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689001289 Walker A/P-loop; other site 215689001290 ATP binding site [chemical binding]; other site 215689001291 Q-loop/lid; other site 215689001292 ABC transporter signature motif; other site 215689001293 Walker B; other site 215689001294 D-loop; other site 215689001295 H-loop/switch region; other site 215689001296 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 215689001297 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 215689001298 DNA polymerase II; Reviewed; Region: PRK05762 215689001299 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 215689001300 active site 215689001301 catalytic site [active] 215689001302 substrate binding site [chemical binding]; other site 215689001303 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 215689001304 active site 215689001305 metal-binding site 215689001306 ATP-dependent helicase HepA; Validated; Region: PRK04914 215689001307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689001308 ATP binding site [chemical binding]; other site 215689001309 putative Mg++ binding site [ion binding]; other site 215689001310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689001311 nucleotide binding region [chemical binding]; other site 215689001312 ATP-binding site [chemical binding]; other site 215689001313 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 215689001314 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 215689001315 active site 215689001316 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 215689001317 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 215689001318 putative metal binding site [ion binding]; other site 215689001319 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 215689001320 HSP70 interaction site [polypeptide binding]; other site 215689001321 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 215689001322 OstA-like protein; Region: OstA; pfam03968 215689001323 Organic solvent tolerance protein; Region: OstA_C; pfam04453 215689001324 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 215689001325 SurA N-terminal domain; Region: SurA_N; pfam09312 215689001326 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 215689001327 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 215689001328 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 215689001329 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 215689001330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689001331 S-adenosylmethionine binding site [chemical binding]; other site 215689001332 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 215689001333 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 215689001334 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 215689001335 active site 215689001336 metal binding site [ion binding]; metal-binding site 215689001337 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 215689001338 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 215689001339 folate binding site [chemical binding]; other site 215689001340 NADP+ binding site [chemical binding]; other site 215689001341 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 215689001342 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 215689001343 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 215689001344 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 215689001345 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 215689001346 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 215689001347 ATP-grasp domain; Region: ATP-grasp_4; cl17255 215689001348 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 215689001349 IMP binding site; other site 215689001350 dimer interface [polypeptide binding]; other site 215689001351 interdomain contacts; other site 215689001352 partial ornithine binding site; other site 215689001353 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 215689001354 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 215689001355 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 215689001356 catalytic site [active] 215689001357 subunit interface [polypeptide binding]; other site 215689001358 dihydrodipicolinate reductase; Provisional; Region: PRK00048 215689001359 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 215689001360 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 215689001361 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 215689001362 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 215689001363 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 215689001364 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 215689001365 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 215689001366 lipoprotein signal peptidase; Provisional; Region: PRK14787 215689001367 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 215689001368 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 215689001369 active site 215689001370 HIGH motif; other site 215689001371 nucleotide binding site [chemical binding]; other site 215689001372 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 215689001373 active site 215689001374 KMSKS motif; other site 215689001375 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 215689001376 tRNA binding surface [nucleotide binding]; other site 215689001377 anticodon binding site; other site 215689001378 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 215689001379 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 215689001380 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 215689001381 active site 215689001382 Riboflavin kinase; Region: Flavokinase; smart00904 215689001383 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 215689001384 chaperone protein DnaJ; Provisional; Region: PRK10767 215689001385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 215689001386 HSP70 interaction site [polypeptide binding]; other site 215689001387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 215689001388 substrate binding site [polypeptide binding]; other site 215689001389 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 215689001390 Zn binding sites [ion binding]; other site 215689001391 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 215689001392 dimer interface [polypeptide binding]; other site 215689001393 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 215689001394 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 215689001395 nucleotide binding site [chemical binding]; other site 215689001396 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 215689001397 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 215689001398 MPT binding site; other site 215689001399 trimer interface [polypeptide binding]; other site 215689001400 transaldolase-like protein; Provisional; Region: PTZ00411 215689001401 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 215689001402 active site 215689001403 dimer interface [polypeptide binding]; other site 215689001404 catalytic residue [active] 215689001405 hypothetical protein; Validated; Region: PRK02101 215689001406 threonine synthase; Validated; Region: PRK09225 215689001407 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 215689001408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689001409 catalytic residue [active] 215689001410 homoserine kinase; Provisional; Region: PRK01212 215689001411 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 215689001412 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 215689001413 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 215689001414 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 215689001415 putative catalytic residues [active] 215689001416 putative nucleotide binding site [chemical binding]; other site 215689001417 putative aspartate binding site [chemical binding]; other site 215689001418 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 215689001419 dimer interface [polypeptide binding]; other site 215689001420 putative threonine allosteric regulatory site; other site 215689001421 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 215689001422 putative threonine allosteric regulatory site; other site 215689001423 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 215689001424 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 215689001425 two-component response regulator; Provisional; Region: PRK11173 215689001426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689001427 active site 215689001428 phosphorylation site [posttranslational modification] 215689001429 intermolecular recognition site; other site 215689001430 dimerization interface [polypeptide binding]; other site 215689001431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689001432 DNA binding site [nucleotide binding] 215689001433 hypothetical protein; Provisional; Region: PRK10756 215689001434 CreA protein; Region: CreA; pfam05981 215689001435 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 215689001436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689001437 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 215689001438 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 215689001439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 215689001440 catalytic core [active] 215689001441 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 215689001442 Trp operon repressor; Provisional; Region: PRK01381 215689001443 lytic murein transglycosylase; Provisional; Region: PRK11619 215689001444 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689001445 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689001446 catalytic residue [active] 215689001447 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 215689001448 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 215689001449 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 215689001450 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 215689001451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689001452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689001453 ABC transporter; Region: ABC_tran_2; pfam12848 215689001454 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689001455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689001456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689001457 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 215689001458 putative effector binding pocket; other site 215689001459 dimerization interface [polypeptide binding]; other site 215689001460 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 215689001461 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 215689001462 putative NAD(P) binding site [chemical binding]; other site 215689001463 dimer interface [polypeptide binding]; other site 215689001464 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 215689001465 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 215689001466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689001467 non-specific DNA binding site [nucleotide binding]; other site 215689001468 salt bridge; other site 215689001469 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 215689001470 sequence-specific DNA binding site [nucleotide binding]; other site 215689001471 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 215689001472 active site 215689001473 (T/H)XGH motif; other site 215689001474 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 215689001475 DNA repair protein RadA; Region: sms; TIGR00416 215689001476 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 215689001477 Walker A motif/ATP binding site; other site 215689001478 ATP binding site [chemical binding]; other site 215689001479 Walker B motif; other site 215689001480 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 215689001481 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 215689001482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689001483 motif II; other site 215689001484 hypothetical protein; Provisional; Region: PRK11246 215689001485 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 215689001486 HipA-like N-terminal domain; Region: HipA_N; pfam07805 215689001487 HipA-like C-terminal domain; Region: HipA_C; pfam07804 215689001488 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 215689001489 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 215689001490 phosphopentomutase; Provisional; Region: PRK05362 215689001491 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 215689001492 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 215689001493 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 215689001494 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 215689001495 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 215689001496 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 215689001497 intersubunit interface [polypeptide binding]; other site 215689001498 active site 215689001499 catalytic residue [active] 215689001500 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 215689001501 active site 215689001502 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 215689001503 nucleophile elbow; other site 215689001504 periplasmic protein; Provisional; Region: PRK10568 215689001505 BON domain; Region: BON; pfam04972 215689001506 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 215689001507 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 215689001508 G1 box; other site 215689001509 putative GEF interaction site [polypeptide binding]; other site 215689001510 GTP/Mg2+ binding site [chemical binding]; other site 215689001511 Switch I region; other site 215689001512 G2 box; other site 215689001513 G3 box; other site 215689001514 Switch II region; other site 215689001515 G4 box; other site 215689001516 G5 box; other site 215689001517 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 215689001518 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 215689001519 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 215689001520 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 215689001521 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 215689001522 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 215689001523 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 215689001524 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 215689001525 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 215689001526 potential frameshift: common BLAST hit: gi|292489469|ref|YP_003532357.1| flagellar L-ring protein 215689001527 PAAR motif; Region: PAAR_motif; pfam05488 215689001528 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 215689001529 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 215689001530 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 215689001531 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 215689001532 Catalytic domain of Protein Kinases; Region: PKc; cd00180 215689001533 active site 215689001534 ATP binding site [chemical binding]; other site 215689001535 substrate binding site [chemical binding]; other site 215689001536 activation loop (A-loop); other site 215689001537 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 215689001538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689001539 Walker A motif; other site 215689001540 ATP binding site [chemical binding]; other site 215689001541 Walker B motif; other site 215689001542 arginine finger; other site 215689001543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689001544 Walker A motif; other site 215689001545 ATP binding site [chemical binding]; other site 215689001546 Walker B motif; other site 215689001547 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 215689001548 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 215689001549 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 215689001550 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 215689001551 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 215689001552 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 215689001553 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 215689001554 ImpE protein; Region: ImpE; pfam07024 215689001555 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 215689001556 active site 215689001557 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 215689001558 phosphopeptide binding site; other site 215689001559 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 215689001560 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 215689001561 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 215689001562 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 215689001563 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 215689001564 Protein of unknown function (DUF796); Region: DUF796; pfam05638 215689001565 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 215689001566 Protein of unknown function (DUF877); Region: DUF877; pfam05943 215689001567 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 215689001568 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 215689001569 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 215689001570 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 215689001571 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 215689001572 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 215689001573 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 215689001574 hypothetical protein; Provisional; Region: PRK07033 215689001575 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 215689001576 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 215689001577 ligand binding site [chemical binding]; other site 215689001578 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 215689001579 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 215689001580 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 215689001581 dUMP phosphatase; Provisional; Region: PRK09449 215689001582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689001583 motif II; other site 215689001584 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 215689001585 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 215689001586 DNA polymerase III subunit psi; Validated; Region: PRK06856 215689001587 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 215689001588 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 215689001589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689001590 S-adenosylmethionine binding site [chemical binding]; other site 215689001591 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 215689001592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 215689001593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 215689001594 metal binding site [ion binding]; metal-binding site 215689001595 active site 215689001596 I-site; other site 215689001597 putative sialic acid transporter; Region: 2A0112; TIGR00891 215689001598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689001599 putative substrate translocation pore; other site 215689001600 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 215689001601 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 215689001602 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 215689001603 active site 215689001604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 215689001605 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689001606 DNA binding site [nucleotide binding] 215689001607 domain linker motif; other site 215689001608 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 215689001609 dimerization interface [polypeptide binding]; other site 215689001610 ligand binding site [chemical binding]; other site 215689001611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689001612 metabolite-proton symporter; Region: 2A0106; TIGR00883 215689001613 putative substrate translocation pore; other site 215689001614 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 215689001615 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 215689001616 PLD-like domain; Region: PLDc_2; pfam13091 215689001617 putative active site [active] 215689001618 catalytic site [active] 215689001619 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 215689001620 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 215689001621 catalytic residues [active] 215689001622 Predicted transcriptional regulator [Transcription]; Region: COG2932 215689001623 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 215689001624 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 215689001625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689001626 ATP binding site [chemical binding]; other site 215689001627 putative Mg++ binding site [ion binding]; other site 215689001628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689001629 nucleotide binding region [chemical binding]; other site 215689001630 ATP-binding site [chemical binding]; other site 215689001631 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 215689001632 ligand binding site [chemical binding]; other site 215689001633 Transposase; Region: HTH_Tnp_1; cl17663 215689001634 putative transposase OrfB; Reviewed; Region: PHA02517 215689001635 Integrase core domain; Region: rve; pfam00665 215689001636 Integrase core domain; Region: rve_2; pfam13333 215689001637 HsdM N-terminal domain; Region: HsdM_N; pfam12161 215689001638 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 215689001639 Methyltransferase domain; Region: Methyltransf_26; pfam13659 215689001640 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 215689001641 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 215689001642 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 215689001643 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 215689001644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689001645 ATP binding site [chemical binding]; other site 215689001646 putative Mg++ binding site [ion binding]; other site 215689001647 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 215689001648 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 215689001649 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 215689001650 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 215689001651 putative active site [active] 215689001652 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 215689001653 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 215689001654 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 215689001655 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 215689001656 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 215689001657 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 215689001658 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 215689001659 putative NAD(P) binding site [chemical binding]; other site 215689001660 active site 215689001661 PTS system, glucitol/sorbitol-specific IIA component; Region: gutA; TIGR00849 215689001662 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 215689001663 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 215689001664 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 215689001665 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 215689001666 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 215689001667 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 215689001668 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 215689001669 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 215689001670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689001671 FeS/SAM binding site; other site 215689001672 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 215689001673 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 215689001674 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 215689001675 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 215689001676 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 215689001677 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 215689001678 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 215689001679 active site 215689001680 dimer interface [polypeptide binding]; other site 215689001681 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 215689001682 high affinity sulphate transporter 1; Region: sulP; TIGR00815 215689001683 Sulfate transporter family; Region: Sulfate_transp; pfam00916 215689001684 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 215689001685 active site clefts [active] 215689001686 zinc binding site [ion binding]; other site 215689001687 dimer interface [polypeptide binding]; other site 215689001688 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 215689001689 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 215689001690 active site 215689001691 FMN binding site [chemical binding]; other site 215689001692 2,4-decadienoyl-CoA binding site; other site 215689001693 catalytic residue [active] 215689001694 4Fe-4S cluster binding site [ion binding]; other site 215689001695 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 215689001696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 215689001697 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 215689001698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689001699 S-adenosylmethionine binding site [chemical binding]; other site 215689001700 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 215689001701 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 215689001702 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 215689001703 Cl- selectivity filter; other site 215689001704 Cl- binding residues [ion binding]; other site 215689001705 pore gating glutamate residue; other site 215689001706 dimer interface [polypeptide binding]; other site 215689001707 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 215689001708 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 215689001709 serine/threonine transporter SstT; Provisional; Region: PRK13628 215689001710 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 215689001711 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 215689001712 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 215689001713 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 215689001714 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 215689001715 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 215689001716 Predicted membrane protein [Function unknown]; Region: COG5393 215689001717 YqjK-like protein; Region: YqjK; pfam13997 215689001718 Predicted membrane protein [Function unknown]; Region: COG2259 215689001719 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 215689001720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689001721 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 215689001722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 215689001723 dimerization interface [polypeptide binding]; other site 215689001724 Pirin-related protein [General function prediction only]; Region: COG1741 215689001725 Pirin; Region: Pirin; pfam02678 215689001726 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 215689001727 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 215689001728 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 215689001729 putative SAM binding site [chemical binding]; other site 215689001730 putative homodimer interface [polypeptide binding]; other site 215689001731 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 215689001732 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 215689001733 putative ligand binding site [chemical binding]; other site 215689001734 hypothetical protein; Reviewed; Region: PRK12497 215689001735 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 215689001736 dimer interface [polypeptide binding]; other site 215689001737 active site 215689001738 outer membrane lipoprotein; Provisional; Region: PRK11023 215689001739 BON domain; Region: BON; pfam04972 215689001740 BON domain; Region: BON; pfam04972 215689001741 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 215689001742 HTH domain; Region: HTH_11; pfam08279 215689001743 Mga helix-turn-helix domain; Region: Mga; pfam05043 215689001744 PRD domain; Region: PRD; pfam00874 215689001745 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 215689001746 active site 215689001747 P-loop; other site 215689001748 phosphorylation site [posttranslational modification] 215689001749 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 215689001750 active site 215689001751 phosphorylation site [posttranslational modification] 215689001752 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 215689001753 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 215689001754 catalytic residue [active] 215689001755 dihydroorotase; Provisional; Region: PRK09237 215689001756 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 215689001757 active site 215689001758 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 215689001759 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 215689001760 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 215689001761 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 215689001762 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 215689001763 peptidase PmbA; Provisional; Region: PRK11040 215689001764 hypothetical protein; Provisional; Region: PRK05255 215689001765 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 215689001766 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 215689001767 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 215689001768 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 215689001769 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 215689001770 AMP binding site [chemical binding]; other site 215689001771 metal binding site [ion binding]; metal-binding site 215689001772 active site 215689001773 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 215689001774 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 215689001775 aromatic chitin/cellulose binding site residues [chemical binding]; other site 215689001776 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 215689001777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689001778 dimerization interface [polypeptide binding]; other site 215689001779 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689001780 dimer interface [polypeptide binding]; other site 215689001781 putative CheW interface [polypeptide binding]; other site 215689001782 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 215689001783 dimer interface [polypeptide binding]; other site 215689001784 substrate binding site [chemical binding]; other site 215689001785 metal binding sites [ion binding]; metal-binding site 215689001786 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 215689001787 putative active site pocket [active] 215689001788 dimerization interface [polypeptide binding]; other site 215689001789 putative catalytic residue [active] 215689001790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 215689001791 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 215689001792 Family of unknown function (DUF490); Region: DUF490; pfam04357 215689001793 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 215689001794 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 215689001795 Surface antigen; Region: Bac_surface_Ag; pfam01103 215689001796 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 215689001797 Domain of unknown function DUF21; Region: DUF21; pfam01595 215689001798 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 215689001799 Transporter associated domain; Region: CorC_HlyC; smart01091 215689001800 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 215689001801 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 215689001802 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 215689001803 active site 215689001804 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 215689001805 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 215689001806 active site 215689001807 metal binding site [ion binding]; metal-binding site 215689001808 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 215689001809 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 215689001810 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 215689001811 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 215689001812 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 215689001813 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 215689001814 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 215689001815 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 215689001816 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 215689001817 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 215689001818 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 215689001819 dimer interface [polypeptide binding]; other site 215689001820 ssDNA binding site [nucleotide binding]; other site 215689001821 tetramer (dimer of dimers) interface [polypeptide binding]; other site 215689001822 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 215689001823 esterase; Provisional; Region: PRK10566 215689001824 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 215689001825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689001826 dimerization interface [polypeptide binding]; other site 215689001827 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 215689001828 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689001829 dimer interface [polypeptide binding]; other site 215689001830 putative CheW interface [polypeptide binding]; other site 215689001831 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 215689001832 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 215689001833 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 215689001834 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 215689001835 exoribonuclease R; Provisional; Region: PRK11642 215689001836 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 215689001837 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 215689001838 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 215689001839 RNB domain; Region: RNB; pfam00773 215689001840 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 215689001841 RNA binding site [nucleotide binding]; other site 215689001842 Transcriptional regulator; Region: Rrf2; cl17282 215689001843 Transcriptional regulator; Region: Rrf2; cl17282 215689001844 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 215689001845 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 215689001846 GDP-binding site [chemical binding]; other site 215689001847 ACT binding site; other site 215689001848 IMP binding site; other site 215689001849 FtsH protease regulator HflC; Provisional; Region: PRK11029 215689001850 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 215689001851 FtsH protease regulator HflK; Provisional; Region: PRK10930 215689001852 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 215689001853 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 215689001854 GTPase HflX; Provisional; Region: PRK11058 215689001855 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 215689001856 HflX GTPase family; Region: HflX; cd01878 215689001857 G1 box; other site 215689001858 GTP/Mg2+ binding site [chemical binding]; other site 215689001859 Switch I region; other site 215689001860 G2 box; other site 215689001861 G3 box; other site 215689001862 Switch II region; other site 215689001863 G4 box; other site 215689001864 G5 box; other site 215689001865 bacterial Hfq-like; Region: Hfq; cd01716 215689001866 hexamer interface [polypeptide binding]; other site 215689001867 Sm1 motif; other site 215689001868 RNA binding site [nucleotide binding]; other site 215689001869 Sm2 motif; other site 215689001870 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 215689001871 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 215689001872 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 215689001873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689001874 ATP binding site [chemical binding]; other site 215689001875 Mg2+ binding site [ion binding]; other site 215689001876 G-X-G motif; other site 215689001877 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 215689001878 ATP binding site [chemical binding]; other site 215689001879 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 215689001880 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 215689001881 AMIN domain; Region: AMIN; pfam11741 215689001882 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 215689001883 active site 215689001884 metal binding site [ion binding]; metal-binding site 215689001885 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 215689001886 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 215689001887 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 215689001888 ADP-binding protein; Provisional; Region: PRK10646 215689001889 putative carbohydrate kinase; Provisional; Region: PRK10565 215689001890 Uncharacterized conserved protein [Function unknown]; Region: COG0062 215689001891 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 215689001892 putative substrate binding site [chemical binding]; other site 215689001893 putative ATP binding site [chemical binding]; other site 215689001894 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 215689001895 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 215689001896 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 215689001897 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 215689001898 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 215689001899 catalytic site [active] 215689001900 putative active site [active] 215689001901 putative substrate binding site [chemical binding]; other site 215689001902 dimer interface [polypeptide binding]; other site 215689001903 GTPase RsgA; Reviewed; Region: PRK12288 215689001904 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 215689001905 RNA binding site [nucleotide binding]; other site 215689001906 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 215689001907 GTPase/Zn-binding domain interface [polypeptide binding]; other site 215689001908 GTP/Mg2+ binding site [chemical binding]; other site 215689001909 G4 box; other site 215689001910 G5 box; other site 215689001911 G1 box; other site 215689001912 Switch I region; other site 215689001913 G2 box; other site 215689001914 G3 box; other site 215689001915 Switch II region; other site 215689001916 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 215689001917 putative mechanosensitive channel protein; Provisional; Region: PRK10929 215689001918 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 215689001919 Mechanosensitive ion channel; Region: MS_channel; pfam00924 215689001920 poxB regulator PoxA; Provisional; Region: PRK09350 215689001921 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 215689001922 motif 1; other site 215689001923 dimer interface [polypeptide binding]; other site 215689001924 active site 215689001925 motif 2; other site 215689001926 motif 3; other site 215689001927 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 215689001928 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 215689001929 Predicted small secreted protein [Function unknown]; Region: COG5510 215689001930 elongation factor P; Validated; Region: PRK00529 215689001931 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 215689001932 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 215689001933 RNA binding site [nucleotide binding]; other site 215689001934 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 215689001935 RNA binding site [nucleotide binding]; other site 215689001936 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 215689001937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689001938 FeS/SAM binding site; other site 215689001939 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 215689001940 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 215689001941 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 215689001942 ring oligomerisation interface [polypeptide binding]; other site 215689001943 ATP/Mg binding site [chemical binding]; other site 215689001944 stacking interactions; other site 215689001945 hinge regions; other site 215689001946 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 215689001947 oligomerisation interface [polypeptide binding]; other site 215689001948 mobile loop; other site 215689001949 roof hairpin; other site 215689001950 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 215689001951 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 215689001952 Aspartase; Region: Aspartase; cd01357 215689001953 active sites [active] 215689001954 tetramer interface [polypeptide binding]; other site 215689001955 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 215689001956 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 215689001957 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 215689001958 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 215689001959 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 215689001960 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 215689001961 DsbD alpha interface [polypeptide binding]; other site 215689001962 catalytic residues [active] 215689001963 putative transcriptional regulator; Provisional; Region: PRK11640 215689001964 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 215689001965 DNA binding site [nucleotide binding] 215689001966 active site 215689001967 Int/Topo IB signature motif; other site 215689001968 catalytic residues [active] 215689001969 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 215689001970 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 215689001971 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 215689001972 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 215689001973 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 215689001974 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 215689001975 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 215689001976 HTH-like domain; Region: HTH_21; pfam13276 215689001977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689001978 Integrase core domain; Region: rve; pfam00665 215689001979 Integrase core domain; Region: rve_3; pfam13683 215689001980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689001981 putative transposase OrfB; Reviewed; Region: PHA02517 215689001982 HTH-like domain; Region: HTH_21; pfam13276 215689001983 Integrase core domain; Region: rve; pfam00665 215689001984 Integrase core domain; Region: rve_3; pfam13683 215689001985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689001986 Transposase; Region: HTH_Tnp_1; pfam01527 215689001987 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 215689001988 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 215689001989 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 215689001990 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 215689001991 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 215689001992 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 215689001993 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 215689001994 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 215689001995 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 215689001996 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 215689001997 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 215689001998 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 215689001999 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 215689002000 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 215689002001 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 215689002002 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 215689002003 Restriction endonuclease; Region: Mrr_cat; pfam04471 215689002004 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 215689002005 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689002006 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689002007 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 215689002008 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 215689002009 HTH-like domain; Region: HTH_21; pfam13276 215689002010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689002011 Integrase core domain; Region: rve; pfam00665 215689002012 Integrase core domain; Region: rve_3; pfam13683 215689002013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689002014 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 215689002015 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 215689002016 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 215689002017 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689002018 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689002019 catalytic residue [active] 215689002020 PilS N terminal; Region: PilS; pfam08805 215689002021 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689002022 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689002023 Type II/IV secretion system protein; Region: T2SE; pfam00437 215689002024 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 215689002025 Walker A motif; other site 215689002026 ATP binding site [chemical binding]; other site 215689002027 Walker B motif; other site 215689002028 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 215689002029 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 215689002030 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 215689002031 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 215689002032 PilM; Region: PilM; pfam07419 215689002033 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 215689002034 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 215689002035 Transposase; Region: HTH_Tnp_1; cl17663 215689002036 putative transposase OrfB; Reviewed; Region: PHA02517 215689002037 Integrase core domain; Region: rve; pfam00665 215689002038 Integrase core domain; Region: rve_2; pfam13333 215689002039 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 215689002040 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 215689002041 dimer interface [polypeptide binding]; other site 215689002042 ssDNA binding site [nucleotide binding]; other site 215689002043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 215689002044 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 215689002045 DNA topoisomerase III; Provisional; Region: PRK07726 215689002046 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 215689002047 active site 215689002048 putative interdomain interaction site [polypeptide binding]; other site 215689002049 putative metal-binding site [ion binding]; other site 215689002050 putative nucleotide binding site [chemical binding]; other site 215689002051 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 215689002052 domain I; other site 215689002053 DNA binding groove [nucleotide binding] 215689002054 phosphate binding site [ion binding]; other site 215689002055 domain II; other site 215689002056 domain III; other site 215689002057 nucleotide binding site [chemical binding]; other site 215689002058 catalytic site [active] 215689002059 domain IV; other site 215689002060 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 215689002061 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 215689002062 Helix-turn-helix domain; Region: HTH_36; pfam13730 215689002063 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 215689002064 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 215689002065 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 215689002066 ParB-like nuclease domain; Region: ParBc; cl02129 215689002067 replicative DNA helicase; Region: DnaB; TIGR00665 215689002068 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 215689002069 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 215689002070 Walker A motif; other site 215689002071 ATP binding site [chemical binding]; other site 215689002072 Walker B motif; other site 215689002073 DNA binding loops [nucleotide binding] 215689002074 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 215689002075 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 215689002076 P-loop; other site 215689002077 Magnesium ion binding site [ion binding]; other site 215689002078 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 215689002079 Magnesium ion binding site [ion binding]; other site 215689002080 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 215689002081 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 215689002082 active site 215689002083 catalytic residues [active] 215689002084 DNA binding site [nucleotide binding] 215689002085 Int/Topo IB signature motif; other site 215689002086 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 215689002087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689002088 Integrase core domain; Region: rve; pfam00665 215689002089 Integrase core domain; Region: rve_3; pfam13683 215689002090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689002091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689002092 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 215689002093 putative transposase OrfB; Reviewed; Region: PHA02517 215689002094 Integrase core domain; Region: rve; pfam00665 215689002095 Integrase core domain; Region: rve_2; pfam13333 215689002096 Transposase; Region: HTH_Tnp_1; cl17663 215689002097 Integrase core domain; Region: rve; pfam00665 215689002098 Integrase core domain; Region: rve_3; pfam13683 215689002099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689002100 Transposase; Region: HTH_Tnp_1; pfam01527 215689002101 potential frameshift: common BLAST hit: gi|170021396|ref|YP_001726350.1| integrase catalytic subunit 215689002102 HTH-like domain; Region: HTH_21; pfam13276 215689002103 Integrase core domain; Region: rve; pfam00665 215689002104 Integrase core domain; Region: rve_3; pfam13683 215689002105 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 215689002106 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 215689002107 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 215689002108 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689002109 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689002110 catalytic residue [active] 215689002111 PilS N terminal; Region: PilS; pfam08805 215689002112 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689002113 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 215689002114 Type II/IV secretion system protein; Region: T2SE; pfam00437 215689002115 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 215689002116 Walker A motif; other site 215689002117 ATP binding site [chemical binding]; other site 215689002118 Walker B motif; other site 215689002119 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 215689002120 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 215689002121 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 215689002122 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 215689002123 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 215689002124 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 215689002125 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689002126 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 215689002127 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 215689002128 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 215689002129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689002130 catalytic residue [active] 215689002131 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 215689002132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 215689002133 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 215689002134 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 215689002135 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 215689002136 IucA / IucC family; Region: IucA_IucC; pfam04183 215689002137 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 215689002138 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 215689002139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 215689002140 N-terminal plug; other site 215689002141 ligand-binding site [chemical binding]; other site 215689002142 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 215689002143 glucose-1-dehydrogenase; Provisional; Region: PRK08936 215689002144 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 215689002145 NAD binding site [chemical binding]; other site 215689002146 homodimer interface [polypeptide binding]; other site 215689002147 active site 215689002148 chaperone protein HchA; Provisional; Region: PRK04155 215689002149 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 215689002150 conserved cys residue [active] 215689002151 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 215689002152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 215689002153 trehalase; Provisional; Region: treF; PRK13270 215689002154 Trehalase; Region: Trehalase; cl17346 215689002155 LysE type translocator; Region: LysE; cl00565 215689002156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689002157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689002158 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 215689002159 putative effector binding pocket; other site 215689002160 dimerization interface [polypeptide binding]; other site 215689002161 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 215689002162 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 215689002163 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 215689002164 NAD(P) binding site [chemical binding]; other site 215689002165 active site 215689002166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689002167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689002168 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 215689002169 putative effector binding pocket; other site 215689002170 putative dimerization interface [polypeptide binding]; other site 215689002171 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 215689002172 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 215689002173 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 215689002174 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 215689002175 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 215689002176 Cytochrome c; Region: Cytochrom_C; cl11414 215689002177 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 215689002178 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 215689002179 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 215689002180 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 215689002181 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 215689002182 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 215689002183 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 215689002184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689002185 putative active site [active] 215689002186 heme pocket [chemical binding]; other site 215689002187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689002188 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 215689002189 putative active site [active] 215689002190 heme pocket [chemical binding]; other site 215689002191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689002192 putative active site [active] 215689002193 heme pocket [chemical binding]; other site 215689002194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689002195 putative active site [active] 215689002196 heme pocket [chemical binding]; other site 215689002197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 215689002198 metal binding site [ion binding]; metal-binding site 215689002199 active site 215689002200 I-site; other site 215689002201 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 215689002202 microcin B17 transporter; Reviewed; Region: PRK11098 215689002203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689002204 PAS domain; Region: PAS_9; pfam13426 215689002205 putative active site [active] 215689002206 heme pocket [chemical binding]; other site 215689002207 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 215689002208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689002209 dimer interface [polypeptide binding]; other site 215689002210 putative CheW interface [polypeptide binding]; other site 215689002211 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 215689002212 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 215689002213 acetyl-CoA synthetase; Provisional; Region: PRK00174 215689002214 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 215689002215 active site 215689002216 CoA binding site [chemical binding]; other site 215689002217 acyl-activating enzyme (AAE) consensus motif; other site 215689002218 AMP binding site [chemical binding]; other site 215689002219 acetate binding site [chemical binding]; other site 215689002220 Predicted membrane protein [Function unknown]; Region: COG3162 215689002221 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 215689002222 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 215689002223 Na binding site [ion binding]; other site 215689002224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689002225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689002226 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 215689002227 putative dimerization interface [polypeptide binding]; other site 215689002228 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 215689002229 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 215689002230 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 215689002231 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 215689002232 putative C-terminal domain interface [polypeptide binding]; other site 215689002233 putative GSH binding site (G-site) [chemical binding]; other site 215689002234 putative dimer interface [polypeptide binding]; other site 215689002235 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 215689002236 putative N-terminal domain interface [polypeptide binding]; other site 215689002237 putative dimer interface [polypeptide binding]; other site 215689002238 putative substrate binding pocket (H-site) [chemical binding]; other site 215689002239 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 215689002240 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 215689002241 DNA binding residues [nucleotide binding] 215689002242 dimer interface [polypeptide binding]; other site 215689002243 [2Fe-2S] cluster binding site [ion binding]; other site 215689002244 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 215689002245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689002246 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 215689002247 DNA-binding interface [nucleotide binding]; DNA binding site 215689002248 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 215689002249 haemagglutination activity domain; Region: Haemagg_act; pfam05860 215689002250 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 215689002251 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 215689002252 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 215689002253 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 215689002254 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 215689002255 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 215689002256 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689002257 DNA binding site [nucleotide binding] 215689002258 Int/Topo IB signature motif; other site 215689002259 active site 215689002260 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 215689002261 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 215689002262 dimer interface [polypeptide binding]; other site 215689002263 ssDNA binding site [nucleotide binding]; other site 215689002264 tetramer (dimer of dimers) interface [polypeptide binding]; other site 215689002265 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 215689002266 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 215689002267 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 215689002268 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 215689002269 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 215689002270 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 215689002271 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 215689002272 putative NAD(P) binding site [chemical binding]; other site 215689002273 putative substrate binding site [chemical binding]; other site 215689002274 catalytic Zn binding site [ion binding]; other site 215689002275 structural Zn binding site [ion binding]; other site 215689002276 dimer interface [polypeptide binding]; other site 215689002277 LysM domain; Region: LysM; pfam01476 215689002278 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 215689002279 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 215689002280 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 215689002281 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 215689002282 Protein of unknown function (DUF419); Region: DUF419; cl15265 215689002283 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 215689002284 LysM domain; Region: LysM; pfam01476 215689002285 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 215689002286 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 215689002287 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 215689002288 Protein of unknown function (DUF419); Region: DUF419; cl15265 215689002289 Uncharacterized conserved protein [Function unknown]; Region: COG0432 215689002290 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 215689002291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689002292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689002293 homodimer interface [polypeptide binding]; other site 215689002294 catalytic residue [active] 215689002295 Uncharacterized conserved protein [Function unknown]; Region: COG1284 215689002296 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 215689002297 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 215689002298 replicative DNA helicase; Provisional; Region: PRK08006 215689002299 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 215689002300 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 215689002301 Walker A motif; other site 215689002302 ATP binding site [chemical binding]; other site 215689002303 Walker B motif; other site 215689002304 DNA binding loops [nucleotide binding] 215689002305 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 215689002306 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 215689002307 NADP binding site [chemical binding]; other site 215689002308 dimer interface [polypeptide binding]; other site 215689002309 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 215689002310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689002311 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689002312 H+ Antiporter protein; Region: 2A0121; TIGR00900 215689002313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689002314 putative substrate translocation pore; other site 215689002315 HEXXH motif domain; Region: mod_HExxH; TIGR04267 215689002316 ThiF family; Region: ThiF; pfam00899 215689002317 ATP binding site [chemical binding]; other site 215689002318 substrate interface [chemical binding]; other site 215689002319 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 215689002320 Cupin-like domain; Region: Cupin_8; pfam13621 215689002321 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 215689002322 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 215689002323 putative NTP binding site [chemical binding]; other site 215689002324 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 215689002325 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 215689002326 FMN binding site [chemical binding]; other site 215689002327 active site 215689002328 catalytic residues [active] 215689002329 substrate binding site [chemical binding]; other site 215689002330 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 215689002331 ferric uptake regulator; Provisional; Region: fur; PRK09462 215689002332 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 215689002333 metal binding site 2 [ion binding]; metal-binding site 215689002334 putative DNA binding helix; other site 215689002335 metal binding site 1 [ion binding]; metal-binding site 215689002336 dimer interface [polypeptide binding]; other site 215689002337 structural Zn2+ binding site [ion binding]; other site 215689002338 hypothetical protein; Provisional; Region: PRK10428 215689002339 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 215689002340 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 215689002341 LexA repressor; Validated; Region: PRK00215 215689002342 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 215689002343 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 215689002344 Catalytic site [active] 215689002345 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 215689002346 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 215689002347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 215689002348 putative acyl-acceptor binding pocket; other site 215689002349 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 215689002350 UbiA prenyltransferase family; Region: UbiA; pfam01040 215689002351 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 215689002352 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 215689002353 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 215689002354 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 215689002355 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 215689002356 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 215689002357 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 215689002358 active site 215689002359 dimer interface [polypeptide binding]; other site 215689002360 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 215689002361 dimer interface [polypeptide binding]; other site 215689002362 active site 215689002363 aspartate kinase III; Validated; Region: PRK09084 215689002364 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 215689002365 nucleotide binding site [chemical binding]; other site 215689002366 substrate binding site [chemical binding]; other site 215689002367 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 215689002368 lysine allosteric regulatory site; other site 215689002369 dimer interface [polypeptide binding]; other site 215689002370 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 215689002371 dimer interface [polypeptide binding]; other site 215689002372 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 215689002373 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 215689002374 PhoU domain; Region: PhoU; pfam01895 215689002375 homoserine O-succinyltransferase; Provisional; Region: PRK05368 215689002376 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 215689002377 proposed active site lysine [active] 215689002378 conserved cys residue [active] 215689002379 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 215689002380 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 215689002381 trimer interface [polypeptide binding]; other site 215689002382 putative metal binding site [ion binding]; other site 215689002383 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 215689002384 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 215689002385 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 215689002386 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 215689002387 shikimate binding site; other site 215689002388 NAD(P) binding site [chemical binding]; other site 215689002389 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 215689002390 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 215689002391 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 215689002392 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 215689002393 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 215689002394 hypothetical protein; Validated; Region: PRK03430 215689002395 hypothetical protein; Provisional; Region: PRK10736 215689002396 DNA protecting protein DprA; Region: dprA; TIGR00732 215689002397 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 215689002398 active site 215689002399 catalytic residues [active] 215689002400 metal binding site [ion binding]; metal-binding site 215689002401 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 215689002402 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 215689002403 putative active site [active] 215689002404 substrate binding site [chemical binding]; other site 215689002405 putative cosubstrate binding site; other site 215689002406 catalytic site [active] 215689002407 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 215689002408 substrate binding site [chemical binding]; other site 215689002409 16S rRNA methyltransferase B; Provisional; Region: PRK10901 215689002410 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 215689002411 putative RNA binding site [nucleotide binding]; other site 215689002412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689002413 S-adenosylmethionine binding site [chemical binding]; other site 215689002414 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 215689002415 TrkA-N domain; Region: TrkA_N; pfam02254 215689002416 TrkA-C domain; Region: TrkA_C; pfam02080 215689002417 TrkA-N domain; Region: TrkA_N; pfam02254 215689002418 TrkA-C domain; Region: TrkA_C; pfam02080 215689002419 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 215689002420 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 215689002421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 215689002422 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 215689002423 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 215689002424 DNA binding residues [nucleotide binding] 215689002425 dimer interface [polypeptide binding]; other site 215689002426 metal binding site [ion binding]; metal-binding site 215689002427 hypothetical protein; Provisional; Region: PRK10203 215689002428 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 215689002429 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 215689002430 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 215689002431 alphaNTD homodimer interface [polypeptide binding]; other site 215689002432 alphaNTD - beta interaction site [polypeptide binding]; other site 215689002433 alphaNTD - beta' interaction site [polypeptide binding]; other site 215689002434 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 215689002435 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 215689002436 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 215689002437 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689002438 RNA binding surface [nucleotide binding]; other site 215689002439 30S ribosomal protein S11; Validated; Region: PRK05309 215689002440 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 215689002441 30S ribosomal protein S13; Region: bact_S13; TIGR03631 215689002442 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 215689002443 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 215689002444 SecY translocase; Region: SecY; pfam00344 215689002445 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 215689002446 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 215689002447 23S rRNA binding site [nucleotide binding]; other site 215689002448 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 215689002449 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 215689002450 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 215689002451 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 215689002452 23S rRNA interface [nucleotide binding]; other site 215689002453 5S rRNA interface [nucleotide binding]; other site 215689002454 L27 interface [polypeptide binding]; other site 215689002455 L5 interface [polypeptide binding]; other site 215689002456 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 215689002457 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 215689002458 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 215689002459 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 215689002460 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 215689002461 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 215689002462 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 215689002463 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 215689002464 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 215689002465 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 215689002466 RNA binding site [nucleotide binding]; other site 215689002467 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 215689002468 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 215689002469 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 215689002470 23S rRNA interface [nucleotide binding]; other site 215689002471 putative translocon interaction site; other site 215689002472 signal recognition particle (SRP54) interaction site; other site 215689002473 L23 interface [polypeptide binding]; other site 215689002474 trigger factor interaction site; other site 215689002475 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 215689002476 23S rRNA interface [nucleotide binding]; other site 215689002477 5S rRNA interface [nucleotide binding]; other site 215689002478 putative antibiotic binding site [chemical binding]; other site 215689002479 L25 interface [polypeptide binding]; other site 215689002480 L27 interface [polypeptide binding]; other site 215689002481 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 215689002482 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 215689002483 G-X-X-G motif; other site 215689002484 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 215689002485 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 215689002486 protein-rRNA interface [nucleotide binding]; other site 215689002487 putative translocon binding site; other site 215689002488 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 215689002489 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 215689002490 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 215689002491 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 215689002492 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 215689002493 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 215689002494 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 215689002495 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 215689002496 elongation factor Tu; Reviewed; Region: PRK00049 215689002497 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 215689002498 G1 box; other site 215689002499 GEF interaction site [polypeptide binding]; other site 215689002500 GTP/Mg2+ binding site [chemical binding]; other site 215689002501 Switch I region; other site 215689002502 G2 box; other site 215689002503 G3 box; other site 215689002504 Switch II region; other site 215689002505 G4 box; other site 215689002506 G5 box; other site 215689002507 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 215689002508 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 215689002509 Antibiotic Binding Site [chemical binding]; other site 215689002510 elongation factor G; Reviewed; Region: PRK00007 215689002511 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 215689002512 G1 box; other site 215689002513 putative GEF interaction site [polypeptide binding]; other site 215689002514 GTP/Mg2+ binding site [chemical binding]; other site 215689002515 Switch I region; other site 215689002516 G2 box; other site 215689002517 G3 box; other site 215689002518 Switch II region; other site 215689002519 G4 box; other site 215689002520 G5 box; other site 215689002521 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 215689002522 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 215689002523 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 215689002524 30S ribosomal protein S7; Validated; Region: PRK05302 215689002525 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 215689002526 S17 interaction site [polypeptide binding]; other site 215689002527 S8 interaction site; other site 215689002528 16S rRNA interaction site [nucleotide binding]; other site 215689002529 streptomycin interaction site [chemical binding]; other site 215689002530 23S rRNA interaction site [nucleotide binding]; other site 215689002531 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 215689002532 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 215689002533 sulfur relay protein TusC; Validated; Region: PRK00211 215689002534 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 215689002535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 215689002536 YheO-like PAS domain; Region: PAS_6; pfam08348 215689002537 HTH domain; Region: HTH_22; pfam13309 215689002538 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 215689002539 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 215689002540 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 215689002541 phi X174 lysis protein; Provisional; Region: PRK02793 215689002542 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 215689002543 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 215689002544 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 215689002545 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 215689002546 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 215689002547 TrkA-N domain; Region: TrkA_N; pfam02254 215689002548 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 215689002549 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 215689002550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689002551 Walker A/P-loop; other site 215689002552 ATP binding site [chemical binding]; other site 215689002553 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689002554 ABC transporter signature motif; other site 215689002555 Walker B; other site 215689002556 D-loop; other site 215689002557 ABC transporter; Region: ABC_tran_2; pfam12848 215689002558 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689002559 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 215689002560 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 215689002561 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 215689002562 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 215689002563 substrate binding pocket [chemical binding]; other site 215689002564 active site 215689002565 iron coordination sites [ion binding]; other site 215689002566 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 215689002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689002568 dimer interface [polypeptide binding]; other site 215689002569 conserved gate region; other site 215689002570 putative PBP binding loops; other site 215689002571 ABC-ATPase subunit interface; other site 215689002572 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 215689002573 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 215689002574 Walker A/P-loop; other site 215689002575 ATP binding site [chemical binding]; other site 215689002576 Q-loop/lid; other site 215689002577 ABC transporter signature motif; other site 215689002578 Walker B; other site 215689002579 D-loop; other site 215689002580 H-loop/switch region; other site 215689002581 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 215689002582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689002583 substrate binding pocket [chemical binding]; other site 215689002584 membrane-bound complex binding site; other site 215689002585 hinge residues; other site 215689002586 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 215689002587 putative hydrolase; Provisional; Region: PRK10985 215689002588 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 215689002589 phosphoribulokinase; Provisional; Region: PRK15453 215689002590 active site 215689002591 hypothetical protein; Provisional; Region: PRK10738 215689002592 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 215689002593 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 215689002594 ligand binding site [chemical binding]; other site 215689002595 flexible hinge region; other site 215689002596 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 215689002597 putative switch regulator; other site 215689002598 non-specific DNA interactions [nucleotide binding]; other site 215689002599 DNA binding site [nucleotide binding] 215689002600 sequence specific DNA binding site [nucleotide binding]; other site 215689002601 putative cAMP binding site [chemical binding]; other site 215689002602 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 215689002603 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 215689002604 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 215689002605 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 215689002606 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 215689002607 inhibitor-cofactor binding pocket; inhibition site 215689002608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689002609 catalytic residue [active] 215689002610 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 215689002611 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 215689002612 glutamine binding [chemical binding]; other site 215689002613 catalytic triad [active] 215689002614 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 215689002615 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 215689002616 substrate binding site [chemical binding]; other site 215689002617 putative transporter; Provisional; Region: PRK03699 215689002618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689002619 putative substrate translocation pore; other site 215689002620 cytosine deaminase; Provisional; Region: PRK09230 215689002621 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 215689002622 active site 215689002623 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 215689002624 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 215689002625 active site 215689002626 HIGH motif; other site 215689002627 dimer interface [polypeptide binding]; other site 215689002628 KMSKS motif; other site 215689002629 phosphoglycolate phosphatase; Provisional; Region: PRK13222 215689002630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689002631 motif II; other site 215689002632 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 215689002633 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 215689002634 substrate binding site [chemical binding]; other site 215689002635 hexamer interface [polypeptide binding]; other site 215689002636 metal binding site [ion binding]; metal-binding site 215689002637 DNA adenine methylase; Provisional; Region: PRK10904 215689002638 hypothetical protein; Reviewed; Region: PRK11901 215689002639 cell division protein DamX; Validated; Region: PRK10905 215689002640 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 215689002641 active site 215689002642 dimer interface [polypeptide binding]; other site 215689002643 metal binding site [ion binding]; metal-binding site 215689002644 shikimate kinase; Reviewed; Region: aroK; PRK00131 215689002645 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 215689002646 ADP binding site [chemical binding]; other site 215689002647 magnesium binding site [ion binding]; other site 215689002648 putative shikimate binding site; other site 215689002649 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 215689002650 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689002651 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 215689002652 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 215689002653 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 215689002654 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 215689002655 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 215689002656 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 215689002657 Transglycosylase; Region: Transgly; pfam00912 215689002658 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 215689002659 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 215689002660 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 215689002661 ADP-ribose binding site [chemical binding]; other site 215689002662 dimer interface [polypeptide binding]; other site 215689002663 active site 215689002664 nudix motif; other site 215689002665 metal binding site [ion binding]; metal-binding site 215689002666 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 215689002667 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689002668 RNA binding surface [nucleotide binding]; other site 215689002669 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 215689002670 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 215689002671 dimerization interface [polypeptide binding]; other site 215689002672 domain crossover interface; other site 215689002673 redox-dependent activation switch; other site 215689002674 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 215689002675 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 215689002676 active site 215689002677 substrate-binding site [chemical binding]; other site 215689002678 metal-binding site [ion binding] 215689002679 ATP binding site [chemical binding]; other site 215689002680 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 215689002681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689002682 dimerization interface [polypeptide binding]; other site 215689002683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689002684 dimer interface [polypeptide binding]; other site 215689002685 phosphorylation site [posttranslational modification] 215689002686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689002687 ATP binding site [chemical binding]; other site 215689002688 Mg2+ binding site [ion binding]; other site 215689002689 G-X-G motif; other site 215689002690 osmolarity response regulator; Provisional; Region: ompR; PRK09468 215689002691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689002692 active site 215689002693 phosphorylation site [posttranslational modification] 215689002694 intermolecular recognition site; other site 215689002695 dimerization interface [polypeptide binding]; other site 215689002696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689002697 DNA binding site [nucleotide binding] 215689002698 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 215689002699 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 215689002700 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 215689002701 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 215689002702 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 215689002703 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 215689002704 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 215689002705 RNA binding site [nucleotide binding]; other site 215689002706 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 215689002707 sucrose phosphorylase; Provisional; Region: PRK13840 215689002708 active site 215689002709 homodimer interface [polypeptide binding]; other site 215689002710 catalytic site [active] 215689002711 carboxylesterase BioH; Provisional; Region: PRK10349 215689002712 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 215689002713 DNA utilization protein GntX; Provisional; Region: PRK11595 215689002714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689002715 active site 215689002716 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 215689002717 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 215689002718 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 215689002719 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 215689002720 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 215689002721 maltodextrin phosphorylase; Provisional; Region: PRK14985 215689002722 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 215689002723 active site pocket [active] 215689002724 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 215689002725 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 215689002726 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 215689002727 intramembrane serine protease GlpG; Provisional; Region: PRK10907 215689002728 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 215689002729 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 215689002730 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 215689002731 active site residue [active] 215689002732 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 215689002733 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 215689002734 glycogen phosphorylase; Provisional; Region: PRK14986 215689002735 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 215689002736 homodimer interface [polypeptide binding]; other site 215689002737 active site pocket [active] 215689002738 glycogen synthase; Provisional; Region: glgA; PRK00654 215689002739 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 215689002740 ADP-binding pocket [chemical binding]; other site 215689002741 homodimer interface [polypeptide binding]; other site 215689002742 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 215689002743 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 215689002744 ligand binding site; other site 215689002745 oligomer interface; other site 215689002746 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 215689002747 dimer interface [polypeptide binding]; other site 215689002748 N-terminal domain interface [polypeptide binding]; other site 215689002749 sulfate 1 binding site; other site 215689002750 glycogen debranching enzyme; Provisional; Region: PRK03705 215689002751 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 215689002752 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 215689002753 active site 215689002754 catalytic site [active] 215689002755 glycogen branching enzyme; Provisional; Region: PRK05402 215689002756 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 215689002757 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 215689002758 active site 215689002759 catalytic site [active] 215689002760 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 215689002761 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 215689002762 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 215689002763 low affinity gluconate transporter; Provisional; Region: PRK10472 215689002764 gluconate transporter; Region: gntP; TIGR00791 215689002765 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 215689002766 ATP-binding site [chemical binding]; other site 215689002767 Gluconate-6-phosphate binding site [chemical binding]; other site 215689002768 Shikimate kinase; Region: SKI; pfam01202 215689002769 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 215689002770 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689002771 DNA binding site [nucleotide binding] 215689002772 domain linker motif; other site 215689002773 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 215689002774 putative ligand binding site [chemical binding]; other site 215689002775 putative dimerization interface [polypeptide binding]; other site 215689002776 Pirin-related protein [General function prediction only]; Region: COG1741 215689002777 Pirin; Region: Pirin; pfam02678 215689002778 putative acetyltransferase YhhY; Provisional; Region: PRK10140 215689002779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689002780 Coenzyme A binding pocket [chemical binding]; other site 215689002781 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 215689002782 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 215689002783 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 215689002784 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 215689002785 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 215689002786 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 215689002787 putative active site [active] 215689002788 catalytic site [active] 215689002789 putative metal binding site [ion binding]; other site 215689002790 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 215689002791 TOBE domain; Region: TOBE_2; pfam08402 215689002792 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 215689002793 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 215689002794 Walker A/P-loop; other site 215689002795 ATP binding site [chemical binding]; other site 215689002796 Q-loop/lid; other site 215689002797 ABC transporter signature motif; other site 215689002798 Walker B; other site 215689002799 D-loop; other site 215689002800 H-loop/switch region; other site 215689002801 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 215689002802 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 215689002803 Walker A/P-loop; other site 215689002804 ATP binding site [chemical binding]; other site 215689002805 Q-loop/lid; other site 215689002806 ABC transporter signature motif; other site 215689002807 Walker B; other site 215689002808 D-loop; other site 215689002809 H-loop/switch region; other site 215689002810 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 215689002811 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 215689002812 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 215689002813 TM-ABC transporter signature motif; other site 215689002814 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 215689002815 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 215689002816 TM-ABC transporter signature motif; other site 215689002817 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 215689002818 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 215689002819 dimerization interface [polypeptide binding]; other site 215689002820 ligand binding site [chemical binding]; other site 215689002821 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 215689002822 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 215689002823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689002824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689002825 DNA binding residues [nucleotide binding] 215689002826 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 215689002827 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 215689002828 cell division protein FtsE; Provisional; Region: PRK10908 215689002829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689002830 Walker A/P-loop; other site 215689002831 ATP binding site [chemical binding]; other site 215689002832 Q-loop/lid; other site 215689002833 ABC transporter signature motif; other site 215689002834 Walker B; other site 215689002835 D-loop; other site 215689002836 H-loop/switch region; other site 215689002837 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 215689002838 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 215689002839 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 215689002840 P loop; other site 215689002841 GTP binding site [chemical binding]; other site 215689002842 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 215689002843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689002844 S-adenosylmethionine binding site [chemical binding]; other site 215689002845 hypothetical protein; Provisional; Region: PRK10910 215689002846 Predicted membrane protein [Function unknown]; Region: COG3714 215689002847 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 215689002848 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 215689002849 metal-binding site [ion binding] 215689002850 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 215689002851 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 215689002852 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 215689002853 CPxP motif; other site 215689002854 hypothetical protein; Provisional; Region: PRK11212 215689002855 hypothetical protein; Provisional; Region: PRK11615 215689002856 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 215689002857 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 215689002858 Metal-binding active site; metal-binding site 215689002859 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 215689002860 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 215689002861 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 215689002862 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 215689002863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 215689002864 PYR/PP interface [polypeptide binding]; other site 215689002865 dimer interface [polypeptide binding]; other site 215689002866 TPP binding site [chemical binding]; other site 215689002867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 215689002868 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 215689002869 TPP-binding site; other site 215689002870 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 215689002871 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 215689002872 substrate binding site [chemical binding]; other site 215689002873 ATP binding site [chemical binding]; other site 215689002874 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 215689002875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 215689002876 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 215689002877 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 215689002878 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 215689002879 putative active site [active] 215689002880 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 215689002881 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 215689002882 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 215689002883 tetrameric interface [polypeptide binding]; other site 215689002884 NAD binding site [chemical binding]; other site 215689002885 catalytic residues [active] 215689002886 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 215689002887 Domain of unknown function DUF20; Region: UPF0118; pfam01594 215689002888 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 215689002889 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 215689002890 proline/glycine betaine transporter; Provisional; Region: PRK10642 215689002891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689002892 putative substrate translocation pore; other site 215689002893 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 215689002894 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 215689002895 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 215689002896 putative NAD(P) binding site [chemical binding]; other site 215689002897 putative substrate binding site [chemical binding]; other site 215689002898 catalytic Zn binding site [ion binding]; other site 215689002899 structural Zn binding site [ion binding]; other site 215689002900 dimer interface [polypeptide binding]; other site 215689002901 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 215689002902 DNA binding residues [nucleotide binding] 215689002903 dimerization interface [polypeptide binding]; other site 215689002904 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 215689002905 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 215689002906 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 215689002907 homotrimer interaction site [polypeptide binding]; other site 215689002908 putative active site [active] 215689002909 ornithine cyclodeaminase; Validated; Region: PRK06199 215689002910 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 215689002911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 215689002912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689002913 Amino acid permease; Region: AA_permease; pfam00324 215689002914 Predicted flavoproteins [General function prediction only]; Region: COG2081 215689002915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 215689002916 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 215689002917 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 215689002918 universal stress protein UspB; Provisional; Region: PRK04960 215689002919 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 215689002920 Ligand Binding Site [chemical binding]; other site 215689002921 putative methyltransferase; Provisional; Region: PRK10742 215689002922 oligopeptidase A; Provisional; Region: PRK10911 215689002923 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 215689002924 active site 215689002925 Zn binding site [ion binding]; other site 215689002926 CAAX protease self-immunity; Region: Abi; pfam02517 215689002927 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 215689002928 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 215689002929 potential frameshift: common BLAST hit: gi|259910154|ref|YP_002650510.1| type I restriction-modification system restriction subunit 215689002930 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 215689002931 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 215689002932 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 215689002933 glutathione reductase; Validated; Region: PRK06116 215689002934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 215689002935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 215689002936 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 215689002937 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 215689002938 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 215689002939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 215689002940 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 215689002941 HTH-like domain; Region: HTH_21; pfam13276 215689002942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689002943 Integrase core domain; Region: rve; pfam00665 215689002944 Integrase core domain; Region: rve_3; pfam13683 215689002945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689002946 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689002947 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 215689002948 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689002949 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689002950 active site 215689002951 DNA binding site [nucleotide binding] 215689002952 Int/Topo IB signature motif; other site 215689002953 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689002954 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689002955 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 215689002956 active site 215689002957 metal binding site [ion binding]; metal-binding site 215689002958 interdomain interaction site; other site 215689002959 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689002960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689002961 non-specific DNA binding site [nucleotide binding]; other site 215689002962 salt bridge; other site 215689002963 sequence-specific DNA binding site [nucleotide binding]; other site 215689002964 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689002965 haemagglutination activity domain; Region: Haemagg_act; pfam05860 215689002966 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689002967 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689002968 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689002969 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689002970 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 215689002971 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 215689002972 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 215689002973 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 215689002974 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 215689002975 FMN-binding pocket [chemical binding]; other site 215689002976 flavin binding motif; other site 215689002977 phosphate binding motif [ion binding]; other site 215689002978 beta-alpha-beta structure motif; other site 215689002979 NAD binding pocket [chemical binding]; other site 215689002980 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 215689002981 catalytic loop [active] 215689002982 iron binding site [ion binding]; other site 215689002983 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 215689002984 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 215689002985 [2Fe-2S] cluster binding site [ion binding]; other site 215689002986 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 215689002987 hydrophobic ligand binding site; other site 215689002988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689002989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689002990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 215689002991 dimerization interface [polypeptide binding]; other site 215689002992 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 215689002993 hypothetical protein; Provisional; Region: PRK05208 215689002994 HlyD family secretion protein; Region: HlyD; pfam00529 215689002995 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689002996 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 215689002997 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 215689002998 putative active site [active] 215689002999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 215689003000 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 215689003001 Walker A/P-loop; other site 215689003002 ATP binding site [chemical binding]; other site 215689003003 Q-loop/lid; other site 215689003004 ABC transporter signature motif; other site 215689003005 Walker B; other site 215689003006 D-loop; other site 215689003007 H-loop/switch region; other site 215689003008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689003009 MULE transposase domain; Region: MULE; pfam10551 215689003010 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 215689003011 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 215689003012 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 215689003013 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 215689003014 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 215689003015 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 215689003016 FAD binding pocket [chemical binding]; other site 215689003017 FAD binding motif [chemical binding]; other site 215689003018 phosphate binding motif [ion binding]; other site 215689003019 NAD binding pocket [chemical binding]; other site 215689003020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 215689003021 Protein of unknown function, DUF482; Region: DUF482; pfam04339 215689003022 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 215689003023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 215689003024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689003025 Walker A/P-loop; other site 215689003026 ATP binding site [chemical binding]; other site 215689003027 Q-loop/lid; other site 215689003028 ABC transporter signature motif; other site 215689003029 Walker B; other site 215689003030 D-loop; other site 215689003031 H-loop/switch region; other site 215689003032 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 215689003033 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 215689003034 putative active site [active] 215689003035 putative NTP binding site [chemical binding]; other site 215689003036 putative nucleic acid binding site [nucleotide binding]; other site 215689003037 AAA domain; Region: AAA_21; pfam13304 215689003038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689003039 ABC transporter signature motif; other site 215689003040 Walker B; other site 215689003041 D-loop; other site 215689003042 H-loop/switch region; other site 215689003043 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 215689003044 Strictosidine synthase; Region: Str_synth; pfam03088 215689003045 sensor protein KdpD; Provisional; Region: PRK10490 215689003046 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 215689003047 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 215689003048 Ligand Binding Site [chemical binding]; other site 215689003049 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 215689003050 GAF domain; Region: GAF_3; pfam13492 215689003051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689003052 dimer interface [polypeptide binding]; other site 215689003053 phosphorylation site [posttranslational modification] 215689003054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689003055 ATP binding site [chemical binding]; other site 215689003056 Mg2+ binding site [ion binding]; other site 215689003057 G-X-G motif; other site 215689003058 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 215689003059 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 215689003060 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 215689003061 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 215689003062 potassium-transporting ATPase subunit F; Provisional; Region: kdpF; PRK14748 215689003063 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 215689003064 active site 215689003065 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 215689003066 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 215689003067 Domain of unknown function DUF; Region: DUF204; pfam02659 215689003068 Domain of unknown function DUF; Region: DUF204; pfam02659 215689003069 hypothetical protein; Provisional; Region: PRK07338 215689003070 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 215689003071 metal binding site [ion binding]; metal-binding site 215689003072 dimer interface [polypeptide binding]; other site 215689003073 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 215689003074 potential frameshift: common BLAST hit: gi|188535488|ref|YP_001909285.1| Magnesium-transporting ATPase, P-type 1 215689003075 magnesium-transporting ATPase; Provisional; Region: PRK15122 215689003076 magnesium-transporting ATPase; Provisional; Region: PRK15122 215689003077 MgtC family; Region: MgtC; pfam02308 215689003078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689003079 metabolite-proton symporter; Region: 2A0106; TIGR00883 215689003080 putative substrate translocation pore; other site 215689003081 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 215689003082 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 215689003083 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 215689003084 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 215689003085 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 215689003086 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 215689003087 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 215689003088 putative diguanylate cyclase; Provisional; Region: PRK13561 215689003089 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 215689003090 metal binding site [ion binding]; metal-binding site 215689003091 active site 215689003092 I-site; other site 215689003093 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 215689003094 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 215689003095 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 215689003096 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 215689003097 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 215689003098 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 215689003099 cellulose synthase regulator protein; Provisional; Region: PRK11114 215689003100 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 215689003101 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 215689003102 DXD motif; other site 215689003103 PilZ domain; Region: PilZ; pfam07238 215689003104 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 215689003105 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 215689003106 P-loop; other site 215689003107 Magnesium ion binding site [ion binding]; other site 215689003108 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 215689003109 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 215689003110 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689003111 Walker A/P-loop; other site 215689003112 ATP binding site [chemical binding]; other site 215689003113 Q-loop/lid; other site 215689003114 ABC transporter signature motif; other site 215689003115 Walker B; other site 215689003116 D-loop; other site 215689003117 H-loop/switch region; other site 215689003118 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 215689003119 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 215689003120 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689003121 Walker A/P-loop; other site 215689003122 ATP binding site [chemical binding]; other site 215689003123 Q-loop/lid; other site 215689003124 ABC transporter signature motif; other site 215689003125 Walker B; other site 215689003126 D-loop; other site 215689003127 H-loop/switch region; other site 215689003128 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 215689003129 dipeptide transporter; Provisional; Region: PRK10913 215689003130 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 215689003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689003132 dimer interface [polypeptide binding]; other site 215689003133 conserved gate region; other site 215689003134 putative PBP binding loops; other site 215689003135 ABC-ATPase subunit interface; other site 215689003136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 215689003137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689003138 dimer interface [polypeptide binding]; other site 215689003139 conserved gate region; other site 215689003140 putative PBP binding loops; other site 215689003141 ABC-ATPase subunit interface; other site 215689003142 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 215689003143 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 215689003144 peptide binding site [polypeptide binding]; other site 215689003145 phosphoethanolamine transferase; Provisional; Region: PRK11560 215689003146 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 215689003147 Sulfatase; Region: Sulfatase; pfam00884 215689003148 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 215689003149 Transcriptional regulators [Transcription]; Region: MarR; COG1846 215689003150 MarR family; Region: MarR; pfam01047 215689003151 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 215689003152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 215689003153 Zn2+ binding site [ion binding]; other site 215689003154 Mg2+ binding site [ion binding]; other site 215689003155 Predicted amidohydrolase [General function prediction only]; Region: COG0388 215689003156 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 215689003157 active site 215689003158 catalytic triad [active] 215689003159 dimer interface [polypeptide binding]; other site 215689003160 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 215689003161 HNH endonuclease; Region: HNH_2; pfam13391 215689003162 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 215689003163 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 215689003164 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 215689003165 potential frameshift: common BLAST hit: gi|188535516|ref|YP_001909313.1| isochorismatase hydrolase 215689003166 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 215689003167 conserved cis-peptide bond; other site 215689003168 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 215689003169 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 215689003170 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 215689003171 Uncharacterized conserved protein [Function unknown]; Region: COG4095 215689003172 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 215689003173 Acyltransferase family; Region: Acyl_transf_3; pfam01757 215689003174 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 215689003175 dimer interface [polypeptide binding]; other site 215689003176 motif 1; other site 215689003177 active site 215689003178 motif 2; other site 215689003179 motif 3; other site 215689003180 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 215689003181 DALR anticodon binding domain; Region: DALR_1; pfam05746 215689003182 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 215689003183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689003184 non-specific DNA binding site [nucleotide binding]; other site 215689003185 salt bridge; other site 215689003186 sequence-specific DNA binding site [nucleotide binding]; other site 215689003187 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 215689003188 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 215689003189 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 215689003190 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 215689003191 active site 215689003192 P-loop; other site 215689003193 phosphorylation site [posttranslational modification] 215689003194 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 215689003195 active site 215689003196 phosphorylation site [posttranslational modification] 215689003197 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 215689003198 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 215689003199 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 215689003200 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 215689003201 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 215689003202 hypothetical protein; Provisional; Region: PRK11020 215689003203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 215689003204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689003205 DNA binding residues [nucleotide binding] 215689003206 dimerization interface [polypeptide binding]; other site 215689003207 FaeA-like protein; Region: FaeA; pfam04703 215689003208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 215689003209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 215689003210 DNA binding site [nucleotide binding] 215689003211 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 215689003212 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 215689003213 putative ligand binding site [chemical binding]; other site 215689003214 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 215689003215 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 215689003216 TM-ABC transporter signature motif; other site 215689003217 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 215689003218 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 215689003219 Walker A/P-loop; other site 215689003220 ATP binding site [chemical binding]; other site 215689003221 Q-loop/lid; other site 215689003222 ABC transporter signature motif; other site 215689003223 Walker B; other site 215689003224 D-loop; other site 215689003225 H-loop/switch region; other site 215689003226 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 215689003227 superoxide dismutase; Provisional; Region: PRK10925 215689003228 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 215689003229 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 215689003230 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 215689003231 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 215689003232 inhibitor-cofactor binding pocket; inhibition site 215689003233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689003234 catalytic residue [active] 215689003235 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 215689003236 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 215689003237 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 215689003238 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 215689003239 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 215689003240 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 215689003241 putative glutathione S-transferase; Provisional; Region: PRK10357 215689003242 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 215689003243 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 215689003244 dimer interface [polypeptide binding]; other site 215689003245 N-terminal domain interface [polypeptide binding]; other site 215689003246 putative substrate binding pocket (H-site) [chemical binding]; other site 215689003247 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 215689003248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 215689003249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689003250 DNA binding site [nucleotide binding] 215689003251 domain linker motif; other site 215689003252 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 215689003253 putative dimerization interface [polypeptide binding]; other site 215689003254 putative ligand binding site [chemical binding]; other site 215689003255 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 215689003256 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 215689003257 active site 215689003258 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 215689003259 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 215689003260 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 215689003261 substrate binding site [chemical binding]; other site 215689003262 ATP binding site [chemical binding]; other site 215689003263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689003264 D-galactonate transporter; Region: 2A0114; TIGR00893 215689003265 putative substrate translocation pore; other site 215689003266 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 215689003267 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 215689003268 dimerization interface [polypeptide binding]; other site 215689003269 ligand binding site [chemical binding]; other site 215689003270 NADP binding site [chemical binding]; other site 215689003271 catalytic site [active] 215689003272 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 215689003273 active site 215689003274 catalytic residues [active] 215689003275 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 215689003276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689003277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689003278 homodimer interface [polypeptide binding]; other site 215689003279 catalytic residue [active] 215689003280 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 215689003281 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 215689003282 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 215689003283 putative dimer interface [polypeptide binding]; other site 215689003284 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 215689003285 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 215689003286 sugar phosphate phosphatase; Provisional; Region: PRK10513 215689003287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689003288 active site 215689003289 motif I; other site 215689003290 motif II; other site 215689003291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689003292 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 215689003293 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 215689003294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689003295 ATP binding site [chemical binding]; other site 215689003296 Mg2+ binding site [ion binding]; other site 215689003297 G-X-G motif; other site 215689003298 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 215689003299 anchoring element; other site 215689003300 dimer interface [polypeptide binding]; other site 215689003301 ATP binding site [chemical binding]; other site 215689003302 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 215689003303 active site 215689003304 putative metal-binding site [ion binding]; other site 215689003305 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 215689003306 recF protein; Region: recf; TIGR00611 215689003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689003308 Walker A/P-loop; other site 215689003309 ATP binding site [chemical binding]; other site 215689003310 Q-loop/lid; other site 215689003311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689003312 ABC transporter signature motif; other site 215689003313 Walker B; other site 215689003314 D-loop; other site 215689003315 H-loop/switch region; other site 215689003316 DNA polymerase III subunit beta; Validated; Region: PRK05643 215689003317 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 215689003318 putative DNA binding surface [nucleotide binding]; other site 215689003319 dimer interface [polypeptide binding]; other site 215689003320 beta-clamp/clamp loader binding surface; other site 215689003321 beta-clamp/translesion DNA polymerase binding surface; other site 215689003322 DnaA N-terminal domain; Region: DnaA_N; pfam11638 215689003323 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 215689003324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689003325 Walker A motif; other site 215689003326 ATP binding site [chemical binding]; other site 215689003327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 215689003328 Walker B motif; other site 215689003329 arginine finger; other site 215689003330 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 215689003331 DnaA box-binding interface [nucleotide binding]; other site 215689003332 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 215689003333 Ribonuclease P; Region: Ribonuclease_P; cl00457 215689003334 hypothetical protein; Validated; Region: PRK00041 215689003335 membrane protein insertase; Provisional; Region: PRK01318 215689003336 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 215689003337 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 215689003338 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 215689003339 trmE is a tRNA modification GTPase; Region: trmE; cd04164 215689003340 G1 box; other site 215689003341 GTP/Mg2+ binding site [chemical binding]; other site 215689003342 Switch I region; other site 215689003343 G2 box; other site 215689003344 Switch II region; other site 215689003345 G3 box; other site 215689003346 G4 box; other site 215689003347 G5 box; other site 215689003348 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 215689003349 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 215689003350 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 215689003351 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 215689003352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 215689003353 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 215689003354 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 215689003355 potential frameshift: common BLAST hit: gi|300719149|ref|YP_003743952.1| major facilitator superfamily protein 215689003356 benzoate transport; Region: 2A0115; TIGR00895 215689003357 putative sialic acid transporter; Provisional; Region: PRK03893 215689003358 transcriptional regulator PhoU; Provisional; Region: PRK11115 215689003359 PhoU domain; Region: PhoU; pfam01895 215689003360 PhoU domain; Region: PhoU; pfam01895 215689003361 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 215689003362 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 215689003363 Walker A/P-loop; other site 215689003364 ATP binding site [chemical binding]; other site 215689003365 Q-loop/lid; other site 215689003366 ABC transporter signature motif; other site 215689003367 Walker B; other site 215689003368 D-loop; other site 215689003369 H-loop/switch region; other site 215689003370 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 215689003371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689003372 dimer interface [polypeptide binding]; other site 215689003373 conserved gate region; other site 215689003374 putative PBP binding loops; other site 215689003375 ABC-ATPase subunit interface; other site 215689003376 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 215689003377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689003378 dimer interface [polypeptide binding]; other site 215689003379 conserved gate region; other site 215689003380 putative PBP binding loops; other site 215689003381 ABC-ATPase subunit interface; other site 215689003382 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689003383 substrate binding pocket [chemical binding]; other site 215689003384 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 215689003385 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 215689003386 glutaminase active site [active] 215689003387 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 215689003388 dimer interface [polypeptide binding]; other site 215689003389 active site 215689003390 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 215689003391 dimer interface [polypeptide binding]; other site 215689003392 active site 215689003393 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 215689003394 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 215689003395 Substrate binding site; other site 215689003396 Mg++ binding site; other site 215689003397 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 215689003398 active site 215689003399 substrate binding site [chemical binding]; other site 215689003400 CoA binding site [chemical binding]; other site 215689003401 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 215689003402 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 215689003403 gamma subunit interface [polypeptide binding]; other site 215689003404 epsilon subunit interface [polypeptide binding]; other site 215689003405 LBP interface [polypeptide binding]; other site 215689003406 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 215689003407 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 215689003408 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 215689003409 alpha subunit interaction interface [polypeptide binding]; other site 215689003410 Walker A motif; other site 215689003411 ATP binding site [chemical binding]; other site 215689003412 Walker B motif; other site 215689003413 inhibitor binding site; inhibition site 215689003414 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 215689003415 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 215689003416 core domain interface [polypeptide binding]; other site 215689003417 delta subunit interface [polypeptide binding]; other site 215689003418 epsilon subunit interface [polypeptide binding]; other site 215689003419 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 215689003420 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 215689003421 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 215689003422 beta subunit interaction interface [polypeptide binding]; other site 215689003423 Walker A motif; other site 215689003424 ATP binding site [chemical binding]; other site 215689003425 Walker B motif; other site 215689003426 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 215689003427 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 215689003428 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 215689003429 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 215689003430 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 215689003431 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 215689003432 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 215689003433 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 215689003434 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 215689003435 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 215689003436 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 215689003437 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 215689003438 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 215689003439 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 215689003440 FMN-binding protein MioC; Provisional; Region: PRK09004 215689003441 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 215689003442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 215689003443 putative DNA binding site [nucleotide binding]; other site 215689003444 putative Zn2+ binding site [ion binding]; other site 215689003445 AsnC family; Region: AsnC_trans_reg; pfam01037 215689003446 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 215689003447 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 215689003448 Methyltransferase domain; Region: Methyltransf_23; pfam13489 215689003449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689003450 S-adenosylmethionine binding site [chemical binding]; other site 215689003451 hypothetical protein; Provisional; Region: yieM; PRK10997 215689003452 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 215689003453 metal ion-dependent adhesion site (MIDAS); other site 215689003454 regulatory ATPase RavA; Provisional; Region: PRK13531 215689003455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689003456 Walker A motif; other site 215689003457 ATP binding site [chemical binding]; other site 215689003458 Walker B motif; other site 215689003459 arginine finger; other site 215689003460 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 215689003461 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 215689003462 potassium uptake protein; Region: kup; TIGR00794 215689003463 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 215689003464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689003465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689003466 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 215689003467 putative dimerization interface [polypeptide binding]; other site 215689003468 putative substrate binding pocket [chemical binding]; other site 215689003469 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 215689003470 acetolactate synthase; Reviewed; Region: PRK08617 215689003471 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 215689003472 PYR/PP interface [polypeptide binding]; other site 215689003473 dimer interface [polypeptide binding]; other site 215689003474 TPP binding site [chemical binding]; other site 215689003475 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 215689003476 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 215689003477 TPP-binding site [chemical binding]; other site 215689003478 D-ribose pyranase; Provisional; Region: PRK11797 215689003479 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 215689003480 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 215689003481 Walker A/P-loop; other site 215689003482 ATP binding site [chemical binding]; other site 215689003483 Q-loop/lid; other site 215689003484 ABC transporter signature motif; other site 215689003485 Walker B; other site 215689003486 D-loop; other site 215689003487 H-loop/switch region; other site 215689003488 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 215689003489 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 215689003490 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 215689003491 TM-ABC transporter signature motif; other site 215689003492 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 215689003493 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 215689003494 ligand binding site [chemical binding]; other site 215689003495 dimerization interface [polypeptide binding]; other site 215689003496 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 215689003497 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 215689003498 substrate binding site [chemical binding]; other site 215689003499 dimer interface [polypeptide binding]; other site 215689003500 ATP binding site [chemical binding]; other site 215689003501 transcriptional repressor RbsR; Provisional; Region: PRK10423 215689003502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689003503 DNA binding site [nucleotide binding] 215689003504 domain linker motif; other site 215689003505 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 215689003506 dimerization interface [polypeptide binding]; other site 215689003507 ligand binding site [chemical binding]; other site 215689003508 putative transporter; Provisional; Region: PRK10504 215689003509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689003510 putative substrate translocation pore; other site 215689003511 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 215689003512 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 215689003513 GTP binding site; other site 215689003514 serine/threonine protein kinase; Provisional; Region: PRK11768 215689003515 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 215689003516 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 215689003517 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 215689003518 catalytic residues [active] 215689003519 hinge region; other site 215689003520 alpha helical domain; other site 215689003521 DNA polymerase I; Provisional; Region: PRK05755 215689003522 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 215689003523 active site 215689003524 metal binding site 1 [ion binding]; metal-binding site 215689003525 putative 5' ssDNA interaction site; other site 215689003526 metal binding site 3; metal-binding site 215689003527 metal binding site 2 [ion binding]; metal-binding site 215689003528 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 215689003529 putative DNA binding site [nucleotide binding]; other site 215689003530 putative metal binding site [ion binding]; other site 215689003531 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 215689003532 active site 215689003533 catalytic site [active] 215689003534 substrate binding site [chemical binding]; other site 215689003535 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 215689003536 active site 215689003537 DNA binding site [nucleotide binding] 215689003538 catalytic site [active] 215689003539 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 215689003540 G1 box; other site 215689003541 GTP/Mg2+ binding site [chemical binding]; other site 215689003542 Switch I region; other site 215689003543 G2 box; other site 215689003544 G3 box; other site 215689003545 Switch II region; other site 215689003546 G4 box; other site 215689003547 G5 box; other site 215689003548 Der GTPase activator; Provisional; Region: PRK05244 215689003549 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 215689003550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689003551 FeS/SAM binding site; other site 215689003552 HemN C-terminal domain; Region: HemN_C; pfam06969 215689003553 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 215689003554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689003555 active site 215689003556 phosphorylation site [posttranslational modification] 215689003557 intermolecular recognition site; other site 215689003558 dimerization interface [polypeptide binding]; other site 215689003559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689003560 Walker A motif; other site 215689003561 ATP binding site [chemical binding]; other site 215689003562 Walker B motif; other site 215689003563 arginine finger; other site 215689003564 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 215689003565 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 215689003566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 215689003567 putative active site [active] 215689003568 heme pocket [chemical binding]; other site 215689003569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689003570 dimer interface [polypeptide binding]; other site 215689003571 phosphorylation site [posttranslational modification] 215689003572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689003573 ATP binding site [chemical binding]; other site 215689003574 Mg2+ binding site [ion binding]; other site 215689003575 G-X-G motif; other site 215689003576 glutamine synthetase; Provisional; Region: glnA; PRK09469 215689003577 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 215689003578 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 215689003579 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 215689003580 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 215689003581 G1 box; other site 215689003582 putative GEF interaction site [polypeptide binding]; other site 215689003583 GTP/Mg2+ binding site [chemical binding]; other site 215689003584 Switch I region; other site 215689003585 G2 box; other site 215689003586 G3 box; other site 215689003587 Switch II region; other site 215689003588 G4 box; other site 215689003589 G5 box; other site 215689003590 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 215689003591 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 215689003592 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 215689003593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689003594 motif II; other site 215689003595 hypothetical protein; Reviewed; Region: PRK01637 215689003596 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 215689003597 putative active site [active] 215689003598 dimerization interface [polypeptide binding]; other site 215689003599 putative tRNAtyr binding site [nucleotide binding]; other site 215689003600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 215689003601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689003602 Coenzyme A binding pocket [chemical binding]; other site 215689003603 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 215689003604 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 215689003605 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689003606 RNA binding surface [nucleotide binding]; other site 215689003607 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 215689003608 probable active site [active] 215689003609 AsmA family; Region: AsmA; pfam05170 215689003610 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 215689003611 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 215689003612 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 215689003613 generic binding surface II; other site 215689003614 ssDNA binding site; other site 215689003615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689003616 ATP binding site [chemical binding]; other site 215689003617 putative Mg++ binding site [ion binding]; other site 215689003618 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689003619 nucleotide binding region [chemical binding]; other site 215689003620 ATP-binding site [chemical binding]; other site 215689003621 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 215689003622 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 215689003623 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 215689003624 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 215689003625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 215689003626 Zn2+ binding site [ion binding]; other site 215689003627 Mg2+ binding site [ion binding]; other site 215689003628 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 215689003629 synthetase active site [active] 215689003630 NTP binding site [chemical binding]; other site 215689003631 metal binding site [ion binding]; metal-binding site 215689003632 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 215689003633 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 215689003634 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 215689003635 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 215689003636 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 215689003637 catalytic site [active] 215689003638 G-X2-G-X-G-K; other site 215689003639 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 215689003640 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 215689003641 nucleotide binding pocket [chemical binding]; other site 215689003642 K-X-D-G motif; other site 215689003643 catalytic site [active] 215689003644 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 215689003645 Predicted membrane protein [Function unknown]; Region: COG2860 215689003646 UPF0126 domain; Region: UPF0126; pfam03458 215689003647 UPF0126 domain; Region: UPF0126; pfam03458 215689003648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 215689003649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689003650 active site 215689003651 phosphorylation site [posttranslational modification] 215689003652 intermolecular recognition site; other site 215689003653 dimerization interface [polypeptide binding]; other site 215689003654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689003655 DNA binding residues [nucleotide binding] 215689003656 dimerization interface [polypeptide binding]; other site 215689003657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689003658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 215689003659 putative substrate translocation pore; other site 215689003660 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 215689003661 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 215689003662 PhnA protein; Region: PhnA; pfam03831 215689003663 Predicted transcriptional regulator [Transcription]; Region: COG3905 215689003664 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 215689003665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689003666 HTH-like domain; Region: HTH_21; pfam13276 215689003667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689003668 Integrase core domain; Region: rve; pfam00665 215689003669 Integrase core domain; Region: rve_3; pfam13683 215689003670 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 215689003671 integrase; Provisional; Region: PRK09692 215689003672 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 215689003673 active site 215689003674 Int/Topo IB signature motif; other site 215689003675 hypothetical protein; Provisional; Region: PRK11820 215689003676 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 215689003677 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 215689003678 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 215689003679 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 215689003680 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 215689003681 Nucleoside recognition; Region: Gate; pfam07670 215689003682 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 215689003683 ribonuclease PH; Reviewed; Region: rph; PRK00173 215689003684 Ribonuclease PH; Region: RNase_PH_bact; cd11362 215689003685 hexamer interface [polypeptide binding]; other site 215689003686 active site 215689003687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689003688 active site 215689003689 division inhibitor protein; Provisional; Region: slmA; PRK09480 215689003690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689003691 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 215689003692 trimer interface [polypeptide binding]; other site 215689003693 active site 215689003694 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 215689003695 Flavoprotein; Region: Flavoprotein; pfam02441 215689003696 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 215689003697 hypothetical protein; Reviewed; Region: PRK00024 215689003698 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 215689003699 MPN+ (JAMM) motif; other site 215689003700 Zinc-binding site [ion binding]; other site 215689003701 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 215689003702 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 215689003703 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 215689003704 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 215689003705 DNA binding site [nucleotide binding] 215689003706 catalytic residue [active] 215689003707 H2TH interface [polypeptide binding]; other site 215689003708 putative catalytic residues [active] 215689003709 turnover-facilitating residue; other site 215689003710 intercalation triad [nucleotide binding]; other site 215689003711 8OG recognition residue [nucleotide binding]; other site 215689003712 putative reading head residues; other site 215689003713 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 215689003714 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 215689003715 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 215689003716 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 215689003717 active site 215689003718 (T/H)XGH motif; other site 215689003719 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 215689003720 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 215689003721 putative metal binding site; other site 215689003722 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 215689003723 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 215689003724 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 215689003725 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 215689003726 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 215689003727 putative active site [active] 215689003728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 215689003729 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 215689003730 putative ADP-binding pocket [chemical binding]; other site 215689003731 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 215689003732 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 215689003733 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 215689003734 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 215689003735 putative active site [active] 215689003736 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 215689003737 putative active site [active] 215689003738 putative catalytic site [active] 215689003739 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 215689003740 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 215689003741 putative active site [active] 215689003742 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 215689003743 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 215689003744 active site 215689003745 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 215689003746 O-Antigen ligase; Region: Wzy_C; pfam04932 215689003747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 215689003748 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 215689003749 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 215689003750 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 215689003751 putative active site [active] 215689003752 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 215689003753 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 215689003754 putative active site [active] 215689003755 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 215689003756 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 215689003757 NADP binding site [chemical binding]; other site 215689003758 homopentamer interface [polypeptide binding]; other site 215689003759 substrate binding site [chemical binding]; other site 215689003760 active site 215689003761 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 215689003762 NodB motif; other site 215689003763 putative active site [active] 215689003764 putative catalytic site [active] 215689003765 Zn binding site [ion binding]; other site 215689003766 AmiB activator; Provisional; Region: PRK11637 215689003767 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 215689003768 Peptidase family M23; Region: Peptidase_M23; pfam01551 215689003769 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 215689003770 active site residue [active] 215689003771 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 215689003772 GSH binding site [chemical binding]; other site 215689003773 catalytic residues [active] 215689003774 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 215689003775 SecA binding site; other site 215689003776 Preprotein binding site; other site 215689003777 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 215689003778 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 215689003779 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 215689003780 serine acetyltransferase; Provisional; Region: cysE; PRK11132 215689003781 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 215689003782 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 215689003783 trimer interface [polypeptide binding]; other site 215689003784 active site 215689003785 substrate binding site [chemical binding]; other site 215689003786 CoA binding site [chemical binding]; other site 215689003787 putative rRNA methylase; Provisional; Region: PRK10358 215689003788 two-component sensor protein; Provisional; Region: cpxA; PRK09470 215689003789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689003790 dimerization interface [polypeptide binding]; other site 215689003791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689003792 dimer interface [polypeptide binding]; other site 215689003793 phosphorylation site [posttranslational modification] 215689003794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689003795 ATP binding site [chemical binding]; other site 215689003796 Mg2+ binding site [ion binding]; other site 215689003797 G-X-G motif; other site 215689003798 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 215689003799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689003800 active site 215689003801 phosphorylation site [posttranslational modification] 215689003802 intermolecular recognition site; other site 215689003803 dimerization interface [polypeptide binding]; other site 215689003804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689003805 DNA binding site [nucleotide binding] 215689003806 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 215689003807 dimer interface [polypeptide binding]; other site 215689003808 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 215689003809 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 215689003810 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 215689003811 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 215689003812 active site 215689003813 ADP/pyrophosphate binding site [chemical binding]; other site 215689003814 dimerization interface [polypeptide binding]; other site 215689003815 allosteric effector site; other site 215689003816 fructose-1,6-bisphosphate binding site; other site 215689003817 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 215689003818 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689003819 substrate binding pocket [chemical binding]; other site 215689003820 membrane-bound complex binding site; other site 215689003821 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 215689003822 inner membrane protein YhjD; Region: TIGR00766 215689003823 putative transposase OrfB; Reviewed; Region: PHA02517 215689003824 Integrase core domain; Region: rve; pfam00665 215689003825 Integrase core domain; Region: rve_2; pfam13333 215689003826 Transposase; Region: HTH_Tnp_1; cl17663 215689003827 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 215689003828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689003829 S-adenosylmethionine binding site [chemical binding]; other site 215689003830 Amidinotransferase; Region: Amidinotransf; cl12043 215689003831 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 215689003832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 215689003833 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 215689003834 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 215689003835 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 215689003836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689003837 Walker A/P-loop; other site 215689003838 ATP binding site [chemical binding]; other site 215689003839 Q-loop/lid; other site 215689003840 ABC transporter signature motif; other site 215689003841 Walker B; other site 215689003842 D-loop; other site 215689003843 H-loop/switch region; other site 215689003844 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 215689003845 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 215689003846 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 215689003847 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 215689003848 Fatty acid desaturase; Region: FA_desaturase; pfam00487 215689003849 putative di-iron ligands [ion binding]; other site 215689003850 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 215689003851 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 215689003852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 215689003853 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 215689003854 malate:quinone oxidoreductase; Validated; Region: PRK05257 215689003855 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 215689003856 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 215689003857 triosephosphate isomerase; Provisional; Region: PRK14567 215689003858 substrate binding site [chemical binding]; other site 215689003859 dimer interface [polypeptide binding]; other site 215689003860 catalytic triad [active] 215689003861 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 215689003862 Predicted membrane protein [Function unknown]; Region: COG3152 215689003863 ferredoxin-NADP reductase; Provisional; Region: PRK10926 215689003864 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 215689003865 FAD binding pocket [chemical binding]; other site 215689003866 FAD binding motif [chemical binding]; other site 215689003867 phosphate binding motif [ion binding]; other site 215689003868 beta-alpha-beta structure motif; other site 215689003869 NAD binding pocket [chemical binding]; other site 215689003870 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 215689003871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689003872 putative substrate translocation pore; other site 215689003873 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 215689003874 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 215689003875 putative active site [active] 215689003876 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 215689003877 glycerol kinase; Provisional; Region: glpK; PRK00047 215689003878 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 215689003879 N- and C-terminal domain interface [polypeptide binding]; other site 215689003880 active site 215689003881 MgATP binding site [chemical binding]; other site 215689003882 catalytic site [active] 215689003883 metal binding site [ion binding]; metal-binding site 215689003884 glycerol binding site [chemical binding]; other site 215689003885 homotetramer interface [polypeptide binding]; other site 215689003886 homodimer interface [polypeptide binding]; other site 215689003887 FBP binding site [chemical binding]; other site 215689003888 protein IIAGlc interface [polypeptide binding]; other site 215689003889 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 215689003890 amphipathic channel; other site 215689003891 Asn-Pro-Ala signature motifs; other site 215689003892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 215689003893 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 215689003894 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 215689003895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689003896 Walker A motif; other site 215689003897 ATP binding site [chemical binding]; other site 215689003898 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 215689003899 Walker B motif; other site 215689003900 arginine finger; other site 215689003901 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 215689003902 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 215689003903 active site 215689003904 HslU subunit interaction site [polypeptide binding]; other site 215689003905 essential cell division protein FtsN; Provisional; Region: PRK10927 215689003906 cell division protein FtsN; Provisional; Region: PRK12757 215689003907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689003908 DNA binding site [nucleotide binding] 215689003909 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 215689003910 domain linker motif; other site 215689003911 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 215689003912 dimerization interface [polypeptide binding]; other site 215689003913 ligand binding site [chemical binding]; other site 215689003914 primosome assembly protein PriA; Validated; Region: PRK05580 215689003915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689003916 ATP binding site [chemical binding]; other site 215689003917 putative Mg++ binding site [ion binding]; other site 215689003918 helicase superfamily c-terminal domain; Region: HELICc; smart00490 215689003919 ATP-binding site [chemical binding]; other site 215689003920 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 215689003921 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 215689003922 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 215689003923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689003924 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 215689003925 Q-loop/lid; other site 215689003926 ABC transporter signature motif; other site 215689003927 Walker B; other site 215689003928 D-loop; other site 215689003929 H-loop/switch region; other site 215689003930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 215689003931 active site 215689003932 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 215689003933 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 215689003934 dimerization interface [polypeptide binding]; other site 215689003935 DNA binding site [nucleotide binding] 215689003936 corepressor binding sites; other site 215689003937 cystathionine gamma-synthase; Provisional; Region: PRK08045 215689003938 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 215689003939 homodimer interface [polypeptide binding]; other site 215689003940 substrate-cofactor binding pocket; other site 215689003941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689003942 catalytic residue [active] 215689003943 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 215689003944 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 215689003945 putative catalytic residues [active] 215689003946 putative nucleotide binding site [chemical binding]; other site 215689003947 putative aspartate binding site [chemical binding]; other site 215689003948 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 215689003949 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 215689003950 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 215689003951 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 215689003952 FAD binding site [chemical binding]; other site 215689003953 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 215689003954 oligomeric interface; other site 215689003955 putative active site [active] 215689003956 homodimer interface [polypeptide binding]; other site 215689003957 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 215689003958 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 215689003959 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 215689003960 acetylornithine deacetylase; Provisional; Region: PRK05111 215689003961 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 215689003962 metal binding site [ion binding]; metal-binding site 215689003963 putative dimer interface [polypeptide binding]; other site 215689003964 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 215689003965 nucleotide binding site [chemical binding]; other site 215689003966 N-acetyl-L-glutamate binding site [chemical binding]; other site 215689003967 argininosuccinate synthase; Provisional; Region: PRK13820 215689003968 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 215689003969 ANP binding site [chemical binding]; other site 215689003970 Substrate Binding Site II [chemical binding]; other site 215689003971 Substrate Binding Site I [chemical binding]; other site 215689003972 argininosuccinate lyase; Provisional; Region: PRK04833 215689003973 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 215689003974 active sites [active] 215689003975 tetramer interface [polypeptide binding]; other site 215689003976 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 215689003977 catalytic triad [active] 215689003978 dimer interface [polypeptide binding]; other site 215689003979 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 215689003980 GSH binding site [chemical binding]; other site 215689003981 catalytic residues [active] 215689003982 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 215689003983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689003984 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 215689003985 dimerization interface [polypeptide binding]; other site 215689003986 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 215689003987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 215689003988 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 215689003989 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 215689003990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689003991 hypothetical protein; Provisional; Region: PRK11056 215689003992 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 215689003993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689003994 S-adenosylmethionine binding site [chemical binding]; other site 215689003995 glutamate racemase; Provisional; Region: PRK00865 215689003996 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 215689003997 FAD binding domain; Region: FAD_binding_4; pfam01565 215689003998 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 215689003999 Biotin operon repressor [Transcription]; Region: BirA; COG1654 215689004000 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 215689004001 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 215689004002 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 215689004003 pantothenate kinase; Provisional; Region: PRK05439 215689004004 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 215689004005 ATP-binding site [chemical binding]; other site 215689004006 CoA-binding site [chemical binding]; other site 215689004007 Mg2+-binding site [ion binding]; other site 215689004008 elongation factor Tu; Reviewed; Region: PRK00049 215689004009 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 215689004010 G1 box; other site 215689004011 GEF interaction site [polypeptide binding]; other site 215689004012 GTP/Mg2+ binding site [chemical binding]; other site 215689004013 Switch I region; other site 215689004014 G2 box; other site 215689004015 G3 box; other site 215689004016 Switch II region; other site 215689004017 G4 box; other site 215689004018 G5 box; other site 215689004019 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 215689004020 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 215689004021 Antibiotic Binding Site [chemical binding]; other site 215689004022 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 215689004023 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 215689004024 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 215689004025 putative homodimer interface [polypeptide binding]; other site 215689004026 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 215689004027 heterodimer interface [polypeptide binding]; other site 215689004028 homodimer interface [polypeptide binding]; other site 215689004029 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 215689004030 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 215689004031 L7/L12 interface [polypeptide binding]; other site 215689004032 23S rRNA interface [nucleotide binding]; other site 215689004033 L25 interface [polypeptide binding]; other site 215689004034 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 215689004035 mRNA/rRNA interface [nucleotide binding]; other site 215689004036 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 215689004037 23S rRNA interface [nucleotide binding]; other site 215689004038 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 215689004039 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 215689004040 core dimer interface [polypeptide binding]; other site 215689004041 peripheral dimer interface [polypeptide binding]; other site 215689004042 L10 interface [polypeptide binding]; other site 215689004043 L11 interface [polypeptide binding]; other site 215689004044 putative EF-Tu interaction site [polypeptide binding]; other site 215689004045 putative EF-G interaction site [polypeptide binding]; other site 215689004046 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 215689004047 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 215689004048 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 215689004049 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 215689004050 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 215689004051 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 215689004052 RPB3 interaction site [polypeptide binding]; other site 215689004053 RPB1 interaction site [polypeptide binding]; other site 215689004054 RPB11 interaction site [polypeptide binding]; other site 215689004055 RPB10 interaction site [polypeptide binding]; other site 215689004056 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 215689004057 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 215689004058 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 215689004059 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 215689004060 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 215689004061 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 215689004062 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 215689004063 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 215689004064 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 215689004065 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 215689004066 DNA binding site [nucleotide binding] 215689004067 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 215689004068 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 215689004069 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 215689004070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 215689004071 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 215689004072 PapC N-terminal domain; Region: PapC_N; pfam13954 215689004073 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 215689004074 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 215689004075 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 215689004076 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 215689004077 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 215689004078 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 215689004079 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 215689004080 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 215689004081 outer membrane protease; Reviewed; Region: PRK10993 215689004082 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 215689004083 thiamine phosphate binding site [chemical binding]; other site 215689004084 active site 215689004085 pyrophosphate binding site [ion binding]; other site 215689004086 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 215689004087 ThiC-associated domain; Region: ThiC-associated; pfam13667 215689004088 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 215689004089 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 215689004090 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 215689004091 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 215689004092 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 215689004093 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 215689004094 putative NADH binding site [chemical binding]; other site 215689004095 putative active site [active] 215689004096 nudix motif; other site 215689004097 putative metal binding site [ion binding]; other site 215689004098 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 215689004099 substrate binding site [chemical binding]; other site 215689004100 active site 215689004101 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 215689004102 Active_site [active] 215689004103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 215689004104 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 215689004105 IHF dimer interface [polypeptide binding]; other site 215689004106 IHF - DNA interface [nucleotide binding]; other site 215689004107 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 215689004108 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 215689004109 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 215689004110 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 215689004111 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 215689004112 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 215689004113 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 215689004114 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 215689004115 purine monophosphate binding site [chemical binding]; other site 215689004116 dimer interface [polypeptide binding]; other site 215689004117 putative catalytic residues [active] 215689004118 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 215689004119 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 215689004120 transcriptional regulator HdfR; Provisional; Region: PRK03601 215689004121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689004122 LysR substrate binding domain; Region: LysR_substrate; pfam03466 215689004123 dimerization interface [polypeptide binding]; other site 215689004124 hypothetical protein; Provisional; Region: PRK11027 215689004125 putative ATP-dependent protease; Provisional; Region: PRK09862 215689004126 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 215689004127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689004128 Walker A motif; other site 215689004129 ATP binding site [chemical binding]; other site 215689004130 Walker B motif; other site 215689004131 arginine finger; other site 215689004132 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 215689004133 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 215689004134 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 215689004135 PYR/PP interface [polypeptide binding]; other site 215689004136 dimer interface [polypeptide binding]; other site 215689004137 TPP binding site [chemical binding]; other site 215689004138 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 215689004139 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 215689004140 TPP-binding site [chemical binding]; other site 215689004141 dimer interface [polypeptide binding]; other site 215689004142 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 215689004143 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 215689004144 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 215689004145 homodimer interface [polypeptide binding]; other site 215689004146 substrate-cofactor binding pocket; other site 215689004147 catalytic residue [active] 215689004148 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 215689004149 threonine dehydratase; Reviewed; Region: PRK09224 215689004150 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 215689004151 tetramer interface [polypeptide binding]; other site 215689004152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689004153 catalytic residue [active] 215689004154 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 215689004155 putative Ile/Val binding site [chemical binding]; other site 215689004156 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 215689004157 putative Ile/Val binding site [chemical binding]; other site 215689004158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689004159 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 215689004160 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 215689004161 putative dimerization interface [polypeptide binding]; other site 215689004162 ketol-acid reductoisomerase; Validated; Region: PRK05225 215689004163 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 215689004164 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 215689004165 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 215689004166 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 215689004167 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 215689004168 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 215689004169 Part of AAA domain; Region: AAA_19; pfam13245 215689004170 Family description; Region: UvrD_C_2; pfam13538 215689004171 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 215689004172 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 215689004173 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 215689004174 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 215689004175 ATP binding site [chemical binding]; other site 215689004176 Mg++ binding site [ion binding]; other site 215689004177 motif III; other site 215689004178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689004179 nucleotide binding region [chemical binding]; other site 215689004180 ATP-binding site [chemical binding]; other site 215689004181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 215689004182 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 215689004183 catalytic residues [active] 215689004184 transcription termination factor Rho; Provisional; Region: rho; PRK09376 215689004185 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 215689004186 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 215689004187 RNA binding site [nucleotide binding]; other site 215689004188 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 215689004189 multimer interface [polypeptide binding]; other site 215689004190 Walker A motif; other site 215689004191 ATP binding site [chemical binding]; other site 215689004192 Walker B motif; other site 215689004193 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 215689004194 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 215689004195 Mg++ binding site [ion binding]; other site 215689004196 putative catalytic motif [active] 215689004197 substrate binding site [chemical binding]; other site 215689004198 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 215689004199 Chain length determinant protein; Region: Wzz; pfam02706 215689004200 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 215689004201 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 215689004202 active site 215689004203 homodimer interface [polypeptide binding]; other site 215689004204 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 215689004205 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 215689004206 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 215689004207 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 215689004208 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 215689004209 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 215689004210 NAD binding site [chemical binding]; other site 215689004211 substrate binding site [chemical binding]; other site 215689004212 homodimer interface [polypeptide binding]; other site 215689004213 active site 215689004214 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 215689004215 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 215689004216 substrate binding site; other site 215689004217 tetramer interface; other site 215689004218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 215689004219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689004220 Coenzyme A binding pocket [chemical binding]; other site 215689004221 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 215689004222 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 215689004223 inhibitor-cofactor binding pocket; inhibition site 215689004224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689004225 catalytic residue [active] 215689004226 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 215689004227 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 215689004228 putative common antigen polymerase; Provisional; Region: PRK02975 215689004229 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 215689004230 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 215689004231 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 215689004232 HemY protein N-terminus; Region: HemY_N; pfam07219 215689004233 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 215689004234 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 215689004235 HemX; Region: HemX; pfam04375 215689004236 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 215689004237 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 215689004238 active site 215689004239 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 215689004240 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 215689004241 domain interfaces; other site 215689004242 active site 215689004243 adenylate cyclase; Provisional; Region: cyaA; PRK09450 215689004244 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 215689004245 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 215689004246 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 215689004247 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 215689004248 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 215689004249 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 215689004250 hypothetical protein; Provisional; Region: PRK10963 215689004251 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 215689004252 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689004253 active site 215689004254 DNA binding site [nucleotide binding] 215689004255 Int/Topo IB signature motif; other site 215689004256 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 215689004257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689004258 motif II; other site 215689004259 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 215689004260 Part of AAA domain; Region: AAA_19; pfam13245 215689004261 Family description; Region: UvrD_C_2; pfam13538 215689004262 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 215689004263 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 215689004264 Cl binding site [ion binding]; other site 215689004265 oligomer interface [polypeptide binding]; other site 215689004266 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 215689004267 CoenzymeA binding site [chemical binding]; other site 215689004268 subunit interaction site [polypeptide binding]; other site 215689004269 PHB binding site; other site 215689004270 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 215689004271 dimerization interface [polypeptide binding]; other site 215689004272 substrate binding site [chemical binding]; other site 215689004273 active site 215689004274 calcium binding site [ion binding]; other site 215689004275 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 215689004276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689004277 ATP binding site [chemical binding]; other site 215689004278 putative Mg++ binding site [ion binding]; other site 215689004279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689004280 nucleotide binding region [chemical binding]; other site 215689004281 ATP-binding site [chemical binding]; other site 215689004282 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 215689004283 Helicase and RNase D C-terminal; Region: HRDC; smart00341 215689004284 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 215689004285 lysophospholipase L2; Provisional; Region: PRK10749 215689004286 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 215689004287 putative hydrolase; Provisional; Region: PRK10976 215689004288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689004289 active site 215689004290 motif I; other site 215689004291 motif II; other site 215689004292 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 215689004293 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 215689004294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689004295 putative substrate translocation pore; other site 215689004296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 215689004297 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 215689004298 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 215689004299 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 215689004300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689004301 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 215689004302 putative dimerization interface [polypeptide binding]; other site 215689004303 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 215689004304 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 215689004305 THF binding site; other site 215689004306 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 215689004307 substrate binding site [chemical binding]; other site 215689004308 THF binding site; other site 215689004309 zinc-binding site [ion binding]; other site 215689004310 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 215689004311 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 215689004312 uridine phosphorylase; Provisional; Region: PRK11178 215689004313 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 215689004314 RmuC family; Region: RmuC; pfam02646 215689004315 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 215689004316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689004317 S-adenosylmethionine binding site [chemical binding]; other site 215689004318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 215689004319 SCP-2 sterol transfer family; Region: SCP2; pfam02036 215689004320 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 215689004321 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 215689004322 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 215689004323 sec-independent translocase; Provisional; Region: PRK01770 215689004324 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 215689004325 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 215689004326 active site 215689004327 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 215689004328 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 215689004329 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 215689004330 homodimer interface [polypeptide binding]; other site 215689004331 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 215689004332 FMN reductase; Validated; Region: fre; PRK08051 215689004333 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 215689004334 FAD binding pocket [chemical binding]; other site 215689004335 FAD binding motif [chemical binding]; other site 215689004336 phosphate binding motif [ion binding]; other site 215689004337 beta-alpha-beta structure motif; other site 215689004338 NAD binding pocket [chemical binding]; other site 215689004339 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 215689004340 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 215689004341 dimer interface [polypeptide binding]; other site 215689004342 active site 215689004343 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 215689004344 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 215689004345 substrate binding site [chemical binding]; other site 215689004346 oxyanion hole (OAH) forming residues; other site 215689004347 trimer interface [polypeptide binding]; other site 215689004348 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 215689004349 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 215689004350 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 215689004351 proline dipeptidase; Provisional; Region: PRK13607 215689004352 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 215689004353 active site 215689004354 hypothetical protein; Provisional; Region: PRK11568 215689004355 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 215689004356 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 215689004357 potassium transporter; Provisional; Region: PRK10750 215689004358 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 215689004359 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 215689004360 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 215689004361 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 215689004362 Walker A/P-loop; other site 215689004363 ATP binding site [chemical binding]; other site 215689004364 Q-loop/lid; other site 215689004365 ABC transporter signature motif; other site 215689004366 Walker B; other site 215689004367 D-loop; other site 215689004368 H-loop/switch region; other site 215689004369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689004370 dimer interface [polypeptide binding]; other site 215689004371 conserved gate region; other site 215689004372 putative PBP binding loops; other site 215689004373 ABC-ATPase subunit interface; other site 215689004374 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 215689004375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689004376 conserved gate region; other site 215689004377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689004378 putative PBP binding loops; other site 215689004379 dimer interface [polypeptide binding]; other site 215689004380 ABC-ATPase subunit interface; other site 215689004381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689004382 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 215689004383 substrate binding pocket [chemical binding]; other site 215689004384 membrane-bound complex binding site; other site 215689004385 hinge residues; other site 215689004386 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 215689004387 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 215689004388 putative acyl-acceptor binding pocket; other site 215689004389 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 215689004390 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 215689004391 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 215689004392 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 215689004393 FMN binding site [chemical binding]; other site 215689004394 active site 215689004395 catalytic residues [active] 215689004396 substrate binding site [chemical binding]; other site 215689004397 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 215689004398 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 215689004399 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 215689004400 Na binding site [ion binding]; other site 215689004401 hypothetical protein; Provisional; Region: PRK10633 215689004402 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 215689004403 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 215689004404 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 215689004405 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 215689004406 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 215689004407 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 215689004408 carboxyltransferase (CT) interaction site; other site 215689004409 biotinylation site [posttranslational modification]; other site 215689004410 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 215689004411 Dehydroquinase class II; Region: DHquinase_II; pfam01220 215689004412 active site 215689004413 trimer interface [polypeptide binding]; other site 215689004414 dimer interface [polypeptide binding]; other site 215689004415 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 215689004416 TMAO/DMSO reductase; Reviewed; Region: PRK05363 215689004417 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 215689004418 Moco binding site; other site 215689004419 metal coordination site [ion binding]; other site 215689004420 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 215689004421 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 215689004422 NADP binding site [chemical binding]; other site 215689004423 dimer interface [polypeptide binding]; other site 215689004424 regulatory protein CsrD; Provisional; Region: PRK11059 215689004425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 215689004426 metal binding site [ion binding]; metal-binding site 215689004427 active site 215689004428 I-site; other site 215689004429 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 215689004430 rod shape-determining protein MreB; Provisional; Region: PRK13927 215689004431 MreB and similar proteins; Region: MreB_like; cd10225 215689004432 nucleotide binding site [chemical binding]; other site 215689004433 Mg binding site [ion binding]; other site 215689004434 putative protofilament interaction site [polypeptide binding]; other site 215689004435 RodZ interaction site [polypeptide binding]; other site 215689004436 rod shape-determining protein MreC; Region: mreC; TIGR00219 215689004437 rod shape-determining protein MreC; Region: MreC; pfam04085 215689004438 rod shape-determining protein MreD; Provisional; Region: PRK11060 215689004439 Maf-like protein; Region: Maf; pfam02545 215689004440 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 215689004441 active site 215689004442 dimer interface [polypeptide binding]; other site 215689004443 ribonuclease G; Provisional; Region: PRK11712 215689004444 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 215689004445 homodimer interface [polypeptide binding]; other site 215689004446 oligonucleotide binding site [chemical binding]; other site 215689004447 hypothetical protein; Provisional; Region: PRK10899 215689004448 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 215689004449 protease TldD; Provisional; Region: tldD; PRK10735 215689004450 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 215689004451 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 215689004452 efflux system membrane protein; Provisional; Region: PRK11594 215689004453 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 215689004454 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 215689004455 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689004456 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 215689004457 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 215689004458 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 215689004459 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 215689004460 arginine repressor; Provisional; Region: PRK05066 215689004461 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 215689004462 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 215689004463 malate dehydrogenase; Provisional; Region: PRK05086 215689004464 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 215689004465 NAD binding site [chemical binding]; other site 215689004466 dimerization interface [polypeptide binding]; other site 215689004467 Substrate binding site [chemical binding]; other site 215689004468 serine endoprotease; Provisional; Region: PRK10898 215689004469 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 215689004470 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 215689004471 protein binding site [polypeptide binding]; other site 215689004472 serine endoprotease; Provisional; Region: PRK10139 215689004473 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 215689004474 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 215689004475 protein binding site [polypeptide binding]; other site 215689004476 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 215689004477 protein binding site [polypeptide binding]; other site 215689004478 hypothetical protein; Provisional; Region: PRK11677 215689004479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 215689004480 Predicted ATPase [General function prediction only]; Region: COG1485 215689004481 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 215689004482 23S rRNA interface [nucleotide binding]; other site 215689004483 L3 interface [polypeptide binding]; other site 215689004484 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 215689004485 stringent starvation protein A; Provisional; Region: sspA; PRK09481 215689004486 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 215689004487 C-terminal domain interface [polypeptide binding]; other site 215689004488 putative GSH binding site (G-site) [chemical binding]; other site 215689004489 dimer interface [polypeptide binding]; other site 215689004490 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 215689004491 dimer interface [polypeptide binding]; other site 215689004492 N-terminal domain interface [polypeptide binding]; other site 215689004493 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 215689004494 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 215689004495 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 215689004496 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 215689004497 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 215689004498 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 215689004499 Flavodoxin; Region: Flavodoxin_1; pfam00258 215689004500 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 215689004501 FAD binding pocket [chemical binding]; other site 215689004502 FAD binding motif [chemical binding]; other site 215689004503 catalytic residues [active] 215689004504 NAD binding pocket [chemical binding]; other site 215689004505 phosphate binding motif [ion binding]; other site 215689004506 beta-alpha-beta structure motif; other site 215689004507 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 215689004508 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 215689004509 active site 215689004510 dimer interface [polypeptide binding]; other site 215689004511 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 215689004512 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 215689004513 active site 215689004514 FMN binding site [chemical binding]; other site 215689004515 substrate binding site [chemical binding]; other site 215689004516 3Fe-4S cluster binding site [ion binding]; other site 215689004517 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 215689004518 domain_subunit interface; other site 215689004519 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 215689004520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689004521 putative active site [active] 215689004522 heme pocket [chemical binding]; other site 215689004523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689004524 dimer interface [polypeptide binding]; other site 215689004525 phosphorylation site [posttranslational modification] 215689004526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689004527 ATP binding site [chemical binding]; other site 215689004528 Mg2+ binding site [ion binding]; other site 215689004529 G-X-G motif; other site 215689004530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689004531 active site 215689004532 phosphorylation site [posttranslational modification] 215689004533 intermolecular recognition site; other site 215689004534 dimerization interface [polypeptide binding]; other site 215689004535 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 215689004536 putative binding surface; other site 215689004537 active site 215689004538 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 215689004539 Transglycosylase; Region: Transgly; cl17702 215689004540 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 215689004541 dimerization domain swap beta strand [polypeptide binding]; other site 215689004542 regulatory protein interface [polypeptide binding]; other site 215689004543 active site 215689004544 regulatory phosphorylation site [posttranslational modification]; other site 215689004545 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 215689004546 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 215689004547 active site 215689004548 phosphorylation site [posttranslational modification] 215689004549 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 215689004550 30S subunit binding site; other site 215689004551 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 215689004552 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 215689004553 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 215689004554 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 215689004555 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 215689004556 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 215689004557 Walker A/P-loop; other site 215689004558 ATP binding site [chemical binding]; other site 215689004559 Q-loop/lid; other site 215689004560 ABC transporter signature motif; other site 215689004561 Walker B; other site 215689004562 D-loop; other site 215689004563 H-loop/switch region; other site 215689004564 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 215689004565 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 215689004566 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 215689004567 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 215689004568 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 215689004569 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 215689004570 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 215689004571 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 215689004572 putative active site [active] 215689004573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 215689004574 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 215689004575 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 215689004576 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 215689004577 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 215689004578 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 215689004579 Walker A/P-loop; other site 215689004580 ATP binding site [chemical binding]; other site 215689004581 Q-loop/lid; other site 215689004582 ABC transporter signature motif; other site 215689004583 Walker B; other site 215689004584 D-loop; other site 215689004585 H-loop/switch region; other site 215689004586 Permease; Region: Permease; cl00510 215689004587 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 215689004588 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 215689004589 mce related protein; Region: MCE; pfam02470 215689004590 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 215689004591 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 215689004592 anti sigma factor interaction site; other site 215689004593 regulatory phosphorylation site [posttranslational modification]; other site 215689004594 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 215689004595 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 215689004596 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 215689004597 hinge; other site 215689004598 active site 215689004599 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 215689004600 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 215689004601 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 215689004602 substrate binding pocket [chemical binding]; other site 215689004603 chain length determination region; other site 215689004604 substrate-Mg2+ binding site; other site 215689004605 catalytic residues [active] 215689004606 aspartate-rich region 1; other site 215689004607 active site lid residues [active] 215689004608 aspartate-rich region 2; other site 215689004609 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 215689004610 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 215689004611 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 215689004612 GTPase CgtA; Reviewed; Region: obgE; PRK12298 215689004613 GTP1/OBG; Region: GTP1_OBG; pfam01018 215689004614 Obg GTPase; Region: Obg; cd01898 215689004615 G1 box; other site 215689004616 GTP/Mg2+ binding site [chemical binding]; other site 215689004617 Switch I region; other site 215689004618 G2 box; other site 215689004619 G3 box; other site 215689004620 Switch II region; other site 215689004621 G4 box; other site 215689004622 G5 box; other site 215689004623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689004624 active site 215689004625 dimerization interface [polypeptide binding]; other site 215689004626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 215689004627 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 215689004628 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 215689004629 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 215689004630 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 215689004631 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 215689004632 RNA-binding protein YhbY; Provisional; Region: PRK10343 215689004633 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 215689004634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689004635 S-adenosylmethionine binding site [chemical binding]; other site 215689004636 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 215689004637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689004638 Walker A motif; other site 215689004639 ATP binding site [chemical binding]; other site 215689004640 Walker B motif; other site 215689004641 arginine finger; other site 215689004642 Peptidase family M41; Region: Peptidase_M41; pfam01434 215689004643 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 215689004644 dihydropteroate synthase; Region: DHPS; TIGR01496 215689004645 substrate binding pocket [chemical binding]; other site 215689004646 dimer interface [polypeptide binding]; other site 215689004647 inhibitor binding site; inhibition site 215689004648 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 215689004649 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 215689004650 active site 215689004651 substrate binding site [chemical binding]; other site 215689004652 metal binding site [ion binding]; metal-binding site 215689004653 Preprotein translocase SecG subunit; Region: SecG; pfam03840 215689004654 ribosome maturation protein RimP; Reviewed; Region: PRK00092 215689004655 Sm and related proteins; Region: Sm_like; cl00259 215689004656 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 215689004657 putative oligomer interface [polypeptide binding]; other site 215689004658 putative RNA binding site [nucleotide binding]; other site 215689004659 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 215689004660 NusA N-terminal domain; Region: NusA_N; pfam08529 215689004661 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 215689004662 RNA binding site [nucleotide binding]; other site 215689004663 homodimer interface [polypeptide binding]; other site 215689004664 NusA-like KH domain; Region: KH_5; pfam13184 215689004665 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 215689004666 G-X-X-G motif; other site 215689004667 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 215689004668 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 215689004669 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 215689004670 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 215689004671 translation initiation factor IF-2; Region: IF-2; TIGR00487 215689004672 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 215689004673 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 215689004674 G1 box; other site 215689004675 putative GEF interaction site [polypeptide binding]; other site 215689004676 GTP/Mg2+ binding site [chemical binding]; other site 215689004677 Switch I region; other site 215689004678 G2 box; other site 215689004679 G3 box; other site 215689004680 Switch II region; other site 215689004681 G4 box; other site 215689004682 G5 box; other site 215689004683 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 215689004684 Translation-initiation factor 2; Region: IF-2; pfam11987 215689004685 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 215689004686 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 215689004687 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 215689004688 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 215689004689 RNA binding site [nucleotide binding]; other site 215689004690 active site 215689004691 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 215689004692 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 215689004693 16S/18S rRNA binding site [nucleotide binding]; other site 215689004694 S13e-L30e interaction site [polypeptide binding]; other site 215689004695 25S rRNA binding site [nucleotide binding]; other site 215689004696 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 215689004697 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 215689004698 RNase E interface [polypeptide binding]; other site 215689004699 trimer interface [polypeptide binding]; other site 215689004700 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 215689004701 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 215689004702 RNase E interface [polypeptide binding]; other site 215689004703 trimer interface [polypeptide binding]; other site 215689004704 active site 215689004705 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 215689004706 RNA binding site [nucleotide binding]; other site 215689004707 domain interface; other site 215689004708 lipoprotein NlpI; Provisional; Region: PRK11189 215689004709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 215689004710 binding surface 215689004711 TPR motif; other site 215689004712 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 215689004713 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 215689004714 ATP binding site [chemical binding]; other site 215689004715 Mg++ binding site [ion binding]; other site 215689004716 motif III; other site 215689004717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689004718 nucleotide binding region [chemical binding]; other site 215689004719 ATP-binding site [chemical binding]; other site 215689004720 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 215689004721 putative RNA binding site [nucleotide binding]; other site 215689004722 hypothetical protein; Provisional; Region: PRK10508 215689004723 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 215689004724 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 215689004725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689004726 Coenzyme A binding pocket [chemical binding]; other site 215689004727 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 215689004728 GIY-YIG motif/motif A; other site 215689004729 putative active site [active] 215689004730 putative metal binding site [ion binding]; other site 215689004731 Predicted membrane protein [Function unknown]; Region: COG3766 215689004732 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 215689004733 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 215689004734 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 215689004735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689004736 FeS/SAM binding site; other site 215689004737 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 215689004738 ATP cone domain; Region: ATP-cone; pfam03477 215689004739 Class III ribonucleotide reductase; Region: RNR_III; cd01675 215689004740 effector binding site; other site 215689004741 active site 215689004742 Zn binding site [ion binding]; other site 215689004743 glycine loop; other site 215689004744 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 215689004745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689004746 ATP binding site [chemical binding]; other site 215689004747 putative Mg++ binding site [ion binding]; other site 215689004748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689004749 nucleotide binding region [chemical binding]; other site 215689004750 ATP-binding site [chemical binding]; other site 215689004751 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 215689004752 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 215689004753 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 215689004754 active site 215689004755 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 215689004756 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 215689004757 homotrimer interaction site [polypeptide binding]; other site 215689004758 putative active site [active] 215689004759 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 215689004760 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 215689004761 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 215689004762 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 215689004763 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 215689004764 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 215689004765 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 215689004766 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 215689004767 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 215689004768 RNase E inhibitor protein; Provisional; Region: PRK11191 215689004769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689004770 Coenzyme A binding pocket [chemical binding]; other site 215689004771 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 215689004772 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 215689004773 HIGH motif; other site 215689004774 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 215689004775 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 215689004776 active site 215689004777 KMSKS motif; other site 215689004778 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 215689004779 tRNA binding surface [nucleotide binding]; other site 215689004780 anticodon binding site; other site 215689004781 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 215689004782 DNA polymerase III subunit chi; Validated; Region: PRK05728 215689004783 multifunctional aminopeptidase A; Provisional; Region: PRK00913 215689004784 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 215689004785 interface (dimer of trimers) [polypeptide binding]; other site 215689004786 Substrate-binding/catalytic site; other site 215689004787 Zn-binding sites [ion binding]; other site 215689004788 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 215689004789 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 215689004790 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 215689004791 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 215689004792 Predicted membrane protein [Function unknown]; Region: COG2733 215689004793 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 215689004794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 215689004795 Walker A motif; other site 215689004796 ATP binding site [chemical binding]; other site 215689004797 hypothetical protein; Provisional; Region: PRK11667 215689004798 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 215689004799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689004800 Transposase; Region: HTH_Tnp_1; pfam01527 215689004801 putative transposase OrfB; Reviewed; Region: PHA02517 215689004802 HTH-like domain; Region: HTH_21; pfam13276 215689004803 Integrase core domain; Region: rve; pfam00665 215689004804 Integrase core domain; Region: rve_3; pfam13683 215689004805 potential frameshift: common BLAST hit: gi|292486894|ref|YP_003529764.1| helicase senataxin 215689004806 Part of AAA domain; Region: AAA_19; pfam13245 215689004807 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 215689004808 AAA domain; Region: AAA_12; pfam13087 215689004809 hypothetical protein; Provisional; Region: PRK10396 215689004810 yecA family protein; Region: ygfB_yecA; TIGR02292 215689004811 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 215689004812 lipoprotein, YaeC family; Region: TIGR00363 215689004813 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689004814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689004815 non-specific DNA binding site [nucleotide binding]; other site 215689004816 salt bridge; other site 215689004817 sequence-specific DNA binding site [nucleotide binding]; other site 215689004818 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 215689004819 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 215689004820 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 215689004821 phosphoglycerol transferase I; Provisional; Region: PRK03776 215689004822 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 215689004823 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 215689004824 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 215689004825 active site 215689004826 SUMO-1 interface [polypeptide binding]; other site 215689004827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 215689004828 dimerization interface [polypeptide binding]; other site 215689004829 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 215689004830 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689004831 dimer interface [polypeptide binding]; other site 215689004832 putative CheW interface [polypeptide binding]; other site 215689004833 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 215689004834 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 215689004835 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 215689004836 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 215689004837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689004838 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 215689004839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689004840 DNA binding residues [nucleotide binding] 215689004841 DNA primase; Validated; Region: dnaG; PRK05667 215689004842 CHC2 zinc finger; Region: zf-CHC2; pfam01807 215689004843 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689004844 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 215689004845 active site 215689004846 metal binding site [ion binding]; metal-binding site 215689004847 interdomain interaction site; other site 215689004848 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 215689004849 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 215689004850 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 215689004851 UGMP family protein; Validated; Region: PRK09604 215689004852 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 215689004853 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 215689004854 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 215689004855 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 215689004856 homooctamer interface [polypeptide binding]; other site 215689004857 active site 215689004858 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 215689004859 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 215689004860 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 215689004861 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 215689004862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 215689004863 Zn2+ binding site [ion binding]; other site 215689004864 Mg2+ binding site [ion binding]; other site 215689004865 SH3 domain-containing protein; Provisional; Region: PRK10884 215689004866 Bacterial SH3 domain homologues; Region: SH3b; smart00287 215689004867 Uncharacterized conserved protein [Function unknown]; Region: COG3025 215689004868 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 215689004869 putative active site [active] 215689004870 putative metal binding residues [ion binding]; other site 215689004871 signature motif; other site 215689004872 putative triphosphate binding site [ion binding]; other site 215689004873 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 215689004874 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 215689004875 metal binding triad; other site 215689004876 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 215689004877 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 215689004878 metal binding triad; other site 215689004879 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 215689004880 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 215689004881 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 215689004882 putative ribose interaction site [chemical binding]; other site 215689004883 putative ADP binding site [chemical binding]; other site 215689004884 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 215689004885 active site 215689004886 nucleotide binding site [chemical binding]; other site 215689004887 HIGH motif; other site 215689004888 KMSKS motif; other site 215689004889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 215689004890 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 215689004891 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 215689004892 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 215689004893 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 215689004894 putative active site [active] 215689004895 metal binding site [ion binding]; metal-binding site 215689004896 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 215689004897 hypothetical protein; Provisional; Region: PRK11653 215689004898 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 215689004899 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 215689004900 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 215689004901 dimer interface [polypeptide binding]; other site 215689004902 ADP-ribose binding site [chemical binding]; other site 215689004903 active site 215689004904 nudix motif; other site 215689004905 metal binding site [ion binding]; metal-binding site 215689004906 putative dehydrogenase; Provisional; Region: PRK11039 215689004907 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 215689004908 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 215689004909 active site 215689004910 metal binding site [ion binding]; metal-binding site 215689004911 hexamer interface [polypeptide binding]; other site 215689004912 esterase YqiA; Provisional; Region: PRK11071 215689004913 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 215689004914 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 215689004915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689004916 ATP binding site [chemical binding]; other site 215689004917 Mg2+ binding site [ion binding]; other site 215689004918 G-X-G motif; other site 215689004919 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 215689004920 anchoring element; other site 215689004921 dimer interface [polypeptide binding]; other site 215689004922 ATP binding site [chemical binding]; other site 215689004923 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 215689004924 active site 215689004925 metal binding site [ion binding]; metal-binding site 215689004926 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 215689004927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689004928 HTH-like domain; Region: HTH_21; pfam13276 215689004929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689004930 Integrase core domain; Region: rve; pfam00665 215689004931 Integrase core domain; Region: rve_3; pfam13683 215689004932 Transposase; Region: HTH_Tnp_1; pfam01527 215689004933 potential frameshift: common BLAST hit: gi|50120584|ref|YP_049751.1| transposase 215689004934 Winged helix-turn helix; Region: HTH_29; pfam13551 215689004935 Helix-turn-helix domain; Region: HTH_28; pfam13518 215689004936 Integrase core domain; Region: rve; pfam00665 215689004937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689004938 Integrase core domain; Region: rve_3; pfam13683 215689004939 Uncharacterized conserved protein [Function unknown]; Region: COG1359 215689004940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689004941 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 215689004942 substrate binding pocket [chemical binding]; other site 215689004943 membrane-bound complex binding site; other site 215689004944 hinge residues; other site 215689004945 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 215689004946 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 215689004947 CAP-like domain; other site 215689004948 active site 215689004949 primary dimer interface [polypeptide binding]; other site 215689004950 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 215689004951 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 215689004952 putative acyl-acceptor binding pocket; other site 215689004953 FtsI repressor; Provisional; Region: PRK10883 215689004954 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 215689004955 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 215689004956 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 215689004957 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 215689004958 active site 215689004959 catalytic tetrad [active] 215689004960 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 215689004961 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 215689004962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689004963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689004964 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 215689004965 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 215689004966 inhibitor-cofactor binding pocket; inhibition site 215689004967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689004968 catalytic residue [active] 215689004969 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 215689004970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689004971 catalytic residue [active] 215689004972 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689004973 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689004974 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689004975 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689004976 active site 215689004977 DNA binding site [nucleotide binding] 215689004978 Int/Topo IB signature motif; other site 215689004979 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689004980 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689004981 Toprim-like; Region: Toprim_2; pfam13155 215689004982 active site 215689004983 metal binding site [ion binding]; metal-binding site 215689004984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689004985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689004986 non-specific DNA binding site [nucleotide binding]; other site 215689004987 salt bridge; other site 215689004988 sequence-specific DNA binding site [nucleotide binding]; other site 215689004989 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689004990 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689004991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689004992 active site 215689004993 DNA binding site [nucleotide binding] 215689004994 Int/Topo IB signature motif; other site 215689004995 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689004996 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689004997 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 215689004998 active site 215689004999 metal binding site [ion binding]; metal-binding site 215689005000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689005001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689005002 non-specific DNA binding site [nucleotide binding]; other site 215689005003 salt bridge; other site 215689005004 sequence-specific DNA binding site [nucleotide binding]; other site 215689005005 potential frameshift: common BLAST hit: gi|259909768|ref|YP_002650124.1| Rhs family protein 215689005006 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 215689005007 RHS protein; Region: RHS; pfam03527 215689005008 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689005009 PAAR motif; Region: PAAR_motif; pfam05488 215689005010 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 215689005011 RHS Repeat; Region: RHS_repeat; pfam05593 215689005012 RHS Repeat; Region: RHS_repeat; pfam05593 215689005013 RHS Repeat; Region: RHS_repeat; pfam05593 215689005014 RHS Repeat; Region: RHS_repeat; cl11982 215689005015 RHS Repeat; Region: RHS_repeat; cl11982 215689005016 RHS Repeat; Region: RHS_repeat; pfam05593 215689005017 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 215689005018 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 215689005019 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 215689005020 cystathionine beta-lyase; Provisional; Region: PRK08114 215689005021 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 215689005022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689005023 catalytic residue [active] 215689005024 biopolymer transport protein ExbB; Provisional; Region: PRK10414 215689005025 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 215689005026 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 215689005027 citrate-proton symporter; Provisional; Region: PRK15075 215689005028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689005029 putative substrate translocation pore; other site 215689005030 oxidoreductase; Provisional; Region: PRK07985 215689005031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 215689005032 NAD(P) binding site [chemical binding]; other site 215689005033 active site 215689005034 Spore Coat Protein U domain; Region: SCPU; pfam05229 215689005035 Spore Coat Protein U domain; Region: SCPU; pfam05229 215689005036 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 215689005037 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 215689005038 PapC C-terminal domain; Region: PapC_C; pfam13953 215689005039 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 215689005040 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 215689005041 Spore Coat Protein U domain; Region: SCPU; pfam05229 215689005042 Spore Coat Protein U domain; Region: SCPU; cl02253 215689005043 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 215689005044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689005045 DNA-binding site [nucleotide binding]; DNA binding site 215689005046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689005047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689005048 homodimer interface [polypeptide binding]; other site 215689005049 catalytic residue [active] 215689005050 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 215689005051 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 215689005052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 215689005053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689005054 DNA binding site [nucleotide binding] 215689005055 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 215689005056 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 215689005057 putative ligand binding residues [chemical binding]; other site 215689005058 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 215689005059 Ferritin-like domain; Region: Ferritin; pfam00210 215689005060 ferroxidase diiron center [ion binding]; other site 215689005061 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 215689005062 Phytochelatin synthase; Region: Phytochelatin; pfam05023 215689005063 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 215689005064 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 215689005065 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 215689005066 beta-galactosidase; Region: BGL; TIGR03356 215689005067 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 215689005068 methionine cluster; other site 215689005069 active site 215689005070 phosphorylation site [posttranslational modification] 215689005071 metal binding site [ion binding]; metal-binding site 215689005072 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 215689005073 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 215689005074 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 215689005075 active site 215689005076 P-loop; other site 215689005077 phosphorylation site [posttranslational modification] 215689005078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 215689005079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689005080 DNA binding site [nucleotide binding] 215689005081 domain linker motif; other site 215689005082 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 215689005083 dimerization interface (closed form) [polypeptide binding]; other site 215689005084 ligand binding site [chemical binding]; other site 215689005085 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 215689005086 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 215689005087 dimerization interface [polypeptide binding]; other site 215689005088 putative Zn2+ binding site [ion binding]; other site 215689005089 putative DNA binding site [nucleotide binding]; other site 215689005090 AsnC family; Region: AsnC_trans_reg; pfam01037 215689005091 aromatic amino acid exporter; Provisional; Region: PRK11689 215689005092 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 215689005093 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 215689005094 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 215689005095 carbon starvation protein A; Provisional; Region: PRK15015 215689005096 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 215689005097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689005098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 215689005099 dimerization interface [polypeptide binding]; other site 215689005100 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 215689005101 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 215689005102 C-lysozyme inhibitor; Provisional; Region: PRK09993 215689005103 VirK protein; Region: VirK; pfam06903 215689005104 Amidinotransferase; Region: Amidinotransf; cl12043 215689005105 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 215689005106 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 215689005107 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 215689005108 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 215689005109 active site 215689005110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689005111 Coenzyme A binding pocket [chemical binding]; other site 215689005112 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 215689005113 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 215689005114 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 215689005115 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 215689005116 type III secretion apparatus protein, YscR/HrcR family; Region: yscR; TIGR01102 215689005117 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 215689005118 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 215689005119 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 215689005120 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 215689005121 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 215689005122 Walker A motif; other site 215689005123 ATP binding site [chemical binding]; other site 215689005124 Walker B motif; other site 215689005125 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 215689005126 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 215689005127 FHIPEP family; Region: FHIPEP; pfam00771 215689005128 HrpJ-like domain; Region: HrpJ; pfam07201 215689005129 TyeA; Region: TyeA; cl07611 215689005130 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 215689005131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689005132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689005133 DNA binding residues [nucleotide binding] 215689005134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689005135 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 215689005136 putative active site [active] 215689005137 heme pocket [chemical binding]; other site 215689005138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689005139 putative active site [active] 215689005140 heme pocket [chemical binding]; other site 215689005141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 215689005142 Histidine kinase; Region: HisKA_3; pfam07730 215689005143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689005144 ATP binding site [chemical binding]; other site 215689005145 Mg2+ binding site [ion binding]; other site 215689005146 G-X-G motif; other site 215689005147 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 215689005148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689005149 active site 215689005150 phosphorylation site [posttranslational modification] 215689005151 intermolecular recognition site; other site 215689005152 dimerization interface [polypeptide binding]; other site 215689005153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689005154 DNA binding residues [nucleotide binding] 215689005155 dimerization interface [polypeptide binding]; other site 215689005156 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 215689005157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689005158 Walker A motif; other site 215689005159 ATP binding site [chemical binding]; other site 215689005160 Walker B motif; other site 215689005161 arginine finger; other site 215689005162 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 215689005163 Type III secretion needle MxiH like; Region: MxiH; pfam09392 215689005164 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 215689005165 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 215689005166 HrpF protein; Region: HrpF; pfam06266 215689005167 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 215689005168 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689005169 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689005170 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 215689005171 HrpZ; Region: Hairpins; pfam04877 215689005172 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 215689005173 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 215689005174 Pectate lyase; Region: Pectate_lyase; pfam03211 215689005175 Pathogenicity factor; Region: AvrE; pfam11725 215689005176 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 215689005177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689005178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689005179 HTH-like domain; Region: HTH_21; pfam13276 215689005180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689005181 Integrase core domain; Region: rve; pfam00665 215689005182 Integrase core domain; Region: rve_3; pfam13683 215689005183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689005184 Transposase; Region: HTH_Tnp_1; pfam01527 215689005185 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 215689005186 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 215689005187 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 215689005188 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 215689005189 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 215689005190 potential frameshift: common BLAST hit: gi|259909631|ref|YP_002649987.1| helicase/relaxase 215689005191 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 215689005192 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 215689005193 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 215689005194 DNA binding site [nucleotide binding] 215689005195 active site 215689005196 Int/Topo IB signature motif; other site 215689005197 catalytic residues [active] 215689005198 ornithine decarboxylase; Provisional; Region: PRK13578 215689005199 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 215689005200 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 215689005201 homodimer interface [polypeptide binding]; other site 215689005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689005203 catalytic residue [active] 215689005204 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 215689005205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 215689005206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689005207 murein transglycosylase C; Provisional; Region: mltC; PRK11671 215689005208 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 215689005209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689005210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689005211 catalytic residue [active] 215689005212 oxidative damage protection protein; Provisional; Region: PRK05408 215689005213 adenine DNA glycosylase; Provisional; Region: PRK10880 215689005214 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 215689005215 minor groove reading motif; other site 215689005216 helix-hairpin-helix signature motif; other site 215689005217 substrate binding pocket [chemical binding]; other site 215689005218 active site 215689005219 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 215689005220 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 215689005221 DNA binding and oxoG recognition site [nucleotide binding] 215689005222 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 215689005223 hypothetical protein; Provisional; Region: PRK11702 215689005224 hypothetical protein; Provisional; Region: PRK10626 215689005225 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 215689005226 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 215689005227 HemN family oxidoreductase; Provisional; Region: PRK05660 215689005228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689005229 FeS/SAM binding site; other site 215689005230 HemN C-terminal domain; Region: HemN_C; pfam06969 215689005231 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 215689005232 active site 215689005233 dimerization interface [polypeptide binding]; other site 215689005234 YGGT family; Region: YGGT; pfam02325 215689005235 YGGT family; Region: YGGT; pfam02325 215689005236 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 215689005237 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 215689005238 catalytic residue [active] 215689005239 AAA domain; Region: AAA_22; pfam13401 215689005240 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 215689005241 Walker A motif; other site 215689005242 ATP binding site [chemical binding]; other site 215689005243 Walker B motif; other site 215689005244 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 215689005245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689005246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689005247 DNA binding residues [nucleotide binding] 215689005248 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 215689005249 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 215689005250 DsbD alpha interface [polypeptide binding]; other site 215689005251 catalytic residues [active] 215689005252 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 215689005253 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 215689005254 catalytic triad [active] 215689005255 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 215689005256 hypothetical protein; Validated; Region: PRK00228 215689005257 glutathione synthetase; Provisional; Region: PRK05246 215689005258 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 215689005259 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 215689005260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 215689005261 RNA methyltransferase, RsmE family; Region: TIGR00046 215689005262 DNA-specific endonuclease I; Provisional; Region: PRK15137 215689005263 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 215689005264 hypothetical protein; Provisional; Region: PRK04860 215689005265 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 215689005266 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 215689005267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689005268 putative substrate translocation pore; other site 215689005269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689005270 S-adenosylmethionine synthetase; Validated; Region: PRK05250 215689005271 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 215689005272 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 215689005273 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 215689005274 arginine decarboxylase; Provisional; Region: PRK05354 215689005275 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 215689005276 dimer interface [polypeptide binding]; other site 215689005277 active site 215689005278 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 215689005279 catalytic residues [active] 215689005280 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 215689005281 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 215689005282 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 215689005283 agmatinase; Region: agmatinase; TIGR01230 215689005284 oligomer interface [polypeptide binding]; other site 215689005285 putative active site [active] 215689005286 Mn binding site [ion binding]; other site 215689005287 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 215689005288 transketolase; Reviewed; Region: PRK12753 215689005289 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 215689005290 TPP-binding site [chemical binding]; other site 215689005291 dimer interface [polypeptide binding]; other site 215689005292 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 215689005293 PYR/PP interface [polypeptide binding]; other site 215689005294 dimer interface [polypeptide binding]; other site 215689005295 TPP binding site [chemical binding]; other site 215689005296 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 215689005297 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 215689005298 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 215689005299 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 215689005300 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 215689005301 Phosphoglycerate kinase; Region: PGK; pfam00162 215689005302 substrate binding site [chemical binding]; other site 215689005303 hinge regions; other site 215689005304 ADP binding site [chemical binding]; other site 215689005305 catalytic site [active] 215689005306 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 215689005307 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 215689005308 active site 215689005309 intersubunit interface [polypeptide binding]; other site 215689005310 zinc binding site [ion binding]; other site 215689005311 Na+ binding site [ion binding]; other site 215689005312 mechanosensitive channel MscS; Provisional; Region: PRK10334 215689005313 Mechanosensitive ion channel; Region: MS_channel; pfam00924 215689005314 LysE type translocator; Region: LysE; cl00565 215689005315 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 215689005316 putative trimer interface [polypeptide binding]; other site 215689005317 putative active site [active] 215689005318 putative substrate binding site [chemical binding]; other site 215689005319 putative CoA binding site [chemical binding]; other site 215689005320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 215689005321 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 215689005322 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 215689005323 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 215689005324 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 215689005325 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 215689005326 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 215689005327 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 215689005328 inhibitor-cofactor binding pocket; inhibition site 215689005329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689005330 catalytic residue [active] 215689005331 LysE type translocator; Region: LysE; cl00565 215689005332 Uncharacterized conserved protein [Function unknown]; Region: COG2968 215689005333 oxidative stress defense protein; Provisional; Region: PRK11087 215689005334 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 215689005335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689005336 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 215689005337 putative dimerization interface [polypeptide binding]; other site 215689005338 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 215689005339 tetramer (dimer of dimers) interface [polypeptide binding]; other site 215689005340 active site 215689005341 dimer interface [polypeptide binding]; other site 215689005342 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 215689005343 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 215689005344 ligand binding site [chemical binding]; other site 215689005345 NAD binding site [chemical binding]; other site 215689005346 tetramer interface [polypeptide binding]; other site 215689005347 catalytic site [active] 215689005348 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 215689005349 L-serine binding site [chemical binding]; other site 215689005350 ACT domain interface; other site 215689005351 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 215689005352 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 215689005353 Z-ring-associated protein; Provisional; Region: PRK10972 215689005354 hypothetical protein; Reviewed; Region: PRK01736 215689005355 proline aminopeptidase P II; Provisional; Region: PRK10879 215689005356 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 215689005357 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 215689005358 active site 215689005359 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 215689005360 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 215689005361 oxidoreductase; Provisional; Region: PRK08013 215689005362 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 215689005363 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 215689005364 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 215689005365 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 215689005366 lipoyl attachment site [posttranslational modification]; other site 215689005367 glycine dehydrogenase; Provisional; Region: PRK05367 215689005368 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 215689005369 tetramer interface [polypeptide binding]; other site 215689005370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689005371 catalytic residue [active] 215689005372 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 215689005373 tetramer interface [polypeptide binding]; other site 215689005374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689005375 catalytic residue [active] 215689005376 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 215689005377 classical (c) SDRs; Region: SDR_c; cd05233 215689005378 NAD(P) binding site [chemical binding]; other site 215689005379 active site 215689005380 HD domain; Region: HD_3; pfam13023 215689005381 hemolysin; Provisional; Region: PRK15087 215689005382 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 215689005383 putative global regulator; Reviewed; Region: PRK09559 215689005384 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 215689005385 hypothetical protein; Provisional; Region: PRK10878 215689005386 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 215689005387 flavodoxin FldB; Provisional; Region: PRK12359 215689005388 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 215689005389 EamA-like transporter family; Region: EamA; pfam00892 215689005390 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 215689005391 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 215689005392 active site 215689005393 Int/Topo IB signature motif; other site 215689005394 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 215689005395 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 215689005396 dimerization domain [polypeptide binding]; other site 215689005397 dimer interface [polypeptide binding]; other site 215689005398 catalytic residues [active] 215689005399 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 215689005400 DHH family; Region: DHH; pfam01368 215689005401 DHHA1 domain; Region: DHHA1; pfam02272 215689005402 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 215689005403 peptide chain release factor 2; Provisional; Region: PRK08787 215689005404 This domain is found in peptide chain release factors; Region: PCRF; smart00937 215689005405 RF-1 domain; Region: RF-1; pfam00472 215689005406 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 215689005407 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 215689005408 dimer interface [polypeptide binding]; other site 215689005409 putative anticodon binding site; other site 215689005410 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 215689005411 motif 1; other site 215689005412 active site 215689005413 motif 2; other site 215689005414 motif 3; other site 215689005415 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 215689005416 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 215689005417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689005418 putative substrate translocation pore; other site 215689005419 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 215689005420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689005421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 215689005422 dimerization interface [polypeptide binding]; other site 215689005423 diaminopimelate decarboxylase; Provisional; Region: PRK11165 215689005424 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 215689005425 active site 215689005426 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 215689005427 substrate binding site [chemical binding]; other site 215689005428 catalytic residues [active] 215689005429 dimer interface [polypeptide binding]; other site 215689005430 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 215689005431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689005432 DNA binding site [nucleotide binding] 215689005433 domain linker motif; other site 215689005434 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 215689005435 dimerization interface (closed form) [polypeptide binding]; other site 215689005436 ligand binding site [chemical binding]; other site 215689005437 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 215689005438 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 215689005439 molybdopterin cofactor binding site [chemical binding]; other site 215689005440 substrate binding site [chemical binding]; other site 215689005441 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 215689005442 molybdopterin cofactor binding site; other site 215689005443 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 215689005444 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005445 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005446 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005447 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 215689005448 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 215689005449 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689005450 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689005451 active site 215689005452 DNA binding site [nucleotide binding] 215689005453 Int/Topo IB signature motif; other site 215689005454 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689005455 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689005456 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 215689005457 active site 215689005458 metal binding site [ion binding]; metal-binding site 215689005459 interdomain interaction site; other site 215689005460 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689005461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689005462 non-specific DNA binding site [nucleotide binding]; other site 215689005463 salt bridge; other site 215689005464 sequence-specific DNA binding site [nucleotide binding]; other site 215689005465 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689005466 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 215689005467 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689005468 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689005469 active site 215689005470 DNA binding site [nucleotide binding] 215689005471 Int/Topo IB signature motif; other site 215689005472 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689005473 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689005474 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 215689005475 active site 215689005476 metal binding site [ion binding]; metal-binding site 215689005477 interdomain interaction site; other site 215689005478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689005479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689005480 non-specific DNA binding site [nucleotide binding]; other site 215689005481 salt bridge; other site 215689005482 sequence-specific DNA binding site [nucleotide binding]; other site 215689005483 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689005484 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005485 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 215689005486 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 215689005487 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005488 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 215689005489 haemagglutination activity domain; Region: Haemagg_act; pfam05860 215689005490 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 215689005491 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005492 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005493 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 215689005494 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 215689005495 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 215689005496 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 215689005497 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 215689005498 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 215689005499 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 215689005500 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 215689005501 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 215689005502 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689005503 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 215689005504 Protein export membrane protein; Region: SecD_SecF; cl14618 215689005505 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 215689005506 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 215689005507 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 215689005508 putative acyl-acceptor binding pocket; other site 215689005509 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 215689005510 acyl-activating enzyme (AAE) consensus motif; other site 215689005511 putative AMP binding site [chemical binding]; other site 215689005512 lysophospholipid transporter LplT; Provisional; Region: PRK11195 215689005513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689005514 putative substrate translocation pore; other site 215689005515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 215689005516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 215689005517 active site 215689005518 catalytic tetrad [active] 215689005519 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 215689005520 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 215689005521 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 215689005522 putative DNA-binding cleft [nucleotide binding]; other site 215689005523 putative DNA clevage site; other site 215689005524 molecular lever; other site 215689005525 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 215689005526 putative active site [active] 215689005527 Ap4A binding site [chemical binding]; other site 215689005528 nudix motif; other site 215689005529 putative metal binding site [ion binding]; other site 215689005530 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 215689005531 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 215689005532 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 215689005533 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 215689005534 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 215689005535 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 215689005536 thymidylate synthase; Reviewed; Region: thyA; PRK01827 215689005537 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 215689005538 dimerization interface [polypeptide binding]; other site 215689005539 active site 215689005540 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 215689005541 hypothetical protein; Provisional; Region: PRK10506 215689005542 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 215689005543 hypothetical protein; Provisional; Region: PRK10557 215689005544 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 215689005545 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 215689005546 hypothetical protein; Provisional; Region: PRK10332 215689005547 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 215689005548 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 215689005549 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 215689005550 protease3; Provisional; Region: PRK15101 215689005551 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 215689005552 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 215689005553 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 215689005554 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 215689005555 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 215689005556 AAA domain; Region: AAA_30; pfam13604 215689005557 Family description; Region: UvrD_C_2; pfam13538 215689005558 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 215689005559 N-acetylglutamate synthase; Validated; Region: PRK05279 215689005560 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 215689005561 putative feedback inhibition sensing region; other site 215689005562 putative nucleotide binding site [chemical binding]; other site 215689005563 putative substrate binding site [chemical binding]; other site 215689005564 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 215689005565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689005566 Coenzyme A binding pocket [chemical binding]; other site 215689005567 AMIN domain; Region: AMIN; pfam11741 215689005568 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 215689005569 active site 215689005570 metal binding site [ion binding]; metal-binding site 215689005571 murein transglycosylase A; Provisional; Region: mltA; PRK11162 215689005572 MltA specific insert domain; Region: MltA; smart00925 215689005573 3D domain; Region: 3D; pfam06725 215689005574 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 215689005575 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 215689005576 putative ATP binding site [chemical binding]; other site 215689005577 putative substrate interface [chemical binding]; other site 215689005578 Fe-S metabolism associated domain; Region: SufE; cl00951 215689005579 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 215689005580 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 215689005581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689005582 catalytic residue [active] 215689005583 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 215689005584 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 215689005585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689005586 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 215689005587 dimerization interface [polypeptide binding]; other site 215689005588 substrate binding pocket [chemical binding]; other site 215689005589 hypothetical protein; Provisional; Region: PRK10873 215689005590 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 215689005591 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 215689005592 flap endonuclease-like protein; Provisional; Region: PRK09482 215689005593 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 215689005594 active site 215689005595 metal binding site 1 [ion binding]; metal-binding site 215689005596 putative 5' ssDNA interaction site; other site 215689005597 metal binding site 3; metal-binding site 215689005598 metal binding site 2 [ion binding]; metal-binding site 215689005599 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 215689005600 putative DNA binding site [nucleotide binding]; other site 215689005601 putative metal binding site [ion binding]; other site 215689005602 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 215689005603 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 215689005604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 215689005605 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 215689005606 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 215689005607 SecY interacting protein Syd; Provisional; Region: PRK04968 215689005608 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 215689005609 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 215689005610 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 215689005611 probable active site [active] 215689005612 flavodoxin; Provisional; Region: PRK08105 215689005613 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 215689005614 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 215689005615 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 215689005616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689005617 dimerization interface [polypeptide binding]; other site 215689005618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689005619 dimer interface [polypeptide binding]; other site 215689005620 phosphorylation site [posttranslational modification] 215689005621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689005622 ATP binding site [chemical binding]; other site 215689005623 Mg2+ binding site [ion binding]; other site 215689005624 G-X-G motif; other site 215689005625 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 215689005626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689005627 active site 215689005628 phosphorylation site [posttranslational modification] 215689005629 intermolecular recognition site; other site 215689005630 dimerization interface [polypeptide binding]; other site 215689005631 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 215689005632 putative binding surface; other site 215689005633 active site 215689005634 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 215689005635 TRAM domain; Region: TRAM; pfam01938 215689005636 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 215689005637 HD domain; Region: HD_4; pfam13328 215689005638 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 215689005639 synthetase active site [active] 215689005640 NTP binding site [chemical binding]; other site 215689005641 metal binding site [ion binding]; metal-binding site 215689005642 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 215689005643 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 215689005644 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 215689005645 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 215689005646 homodimer interface [polypeptide binding]; other site 215689005647 metal binding site [ion binding]; metal-binding site 215689005648 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 215689005649 homodimer interface [polypeptide binding]; other site 215689005650 active site 215689005651 putative chemical substrate binding site [chemical binding]; other site 215689005652 metal binding site [ion binding]; metal-binding site 215689005653 CTP synthetase; Validated; Region: pyrG; PRK05380 215689005654 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 215689005655 Catalytic site [active] 215689005656 active site 215689005657 UTP binding site [chemical binding]; other site 215689005658 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 215689005659 active site 215689005660 putative oxyanion hole; other site 215689005661 catalytic triad [active] 215689005662 enolase; Provisional; Region: eno; PRK00077 215689005663 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 215689005664 dimer interface [polypeptide binding]; other site 215689005665 metal binding site [ion binding]; metal-binding site 215689005666 substrate binding pocket [chemical binding]; other site 215689005667 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 215689005668 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 215689005669 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 215689005670 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 215689005671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689005672 substrate binding pocket [chemical binding]; other site 215689005673 membrane-bound complex binding site; other site 215689005674 hinge residues; other site 215689005675 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 215689005676 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 215689005677 Walker A/P-loop; other site 215689005678 ATP binding site [chemical binding]; other site 215689005679 Q-loop/lid; other site 215689005680 ABC transporter signature motif; other site 215689005681 Walker B; other site 215689005682 D-loop; other site 215689005683 H-loop/switch region; other site 215689005684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689005685 dimer interface [polypeptide binding]; other site 215689005686 conserved gate region; other site 215689005687 putative PBP binding loops; other site 215689005688 ABC-ATPase subunit interface; other site 215689005689 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 215689005690 active site 215689005691 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 215689005692 Flavodoxin; Region: Flavodoxin_1; pfam00258 215689005693 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 215689005694 FAD binding pocket [chemical binding]; other site 215689005695 FAD binding motif [chemical binding]; other site 215689005696 catalytic residues [active] 215689005697 NAD binding pocket [chemical binding]; other site 215689005698 phosphate binding motif [ion binding]; other site 215689005699 beta-alpha-beta structure motif; other site 215689005700 sulfite reductase subunit beta; Provisional; Region: PRK13504 215689005701 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 215689005702 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 215689005703 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 215689005704 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 215689005705 Active Sites [active] 215689005706 YCII-related domain; Region: YCII; cl00999 215689005707 siroheme synthase; Provisional; Region: cysG; PRK10637 215689005708 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 215689005709 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 215689005710 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 215689005711 active site 215689005712 SAM binding site [chemical binding]; other site 215689005713 homodimer interface [polypeptide binding]; other site 215689005714 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 215689005715 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 215689005716 Active Sites [active] 215689005717 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 215689005718 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 215689005719 CysD dimerization site [polypeptide binding]; other site 215689005720 G1 box; other site 215689005721 putative GEF interaction site [polypeptide binding]; other site 215689005722 GTP/Mg2+ binding site [chemical binding]; other site 215689005723 Switch I region; other site 215689005724 G2 box; other site 215689005725 G3 box; other site 215689005726 Switch II region; other site 215689005727 G4 box; other site 215689005728 G5 box; other site 215689005729 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 215689005730 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 215689005731 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 215689005732 ligand-binding site [chemical binding]; other site 215689005733 hypothetical protein; Provisional; Region: PRK10726 215689005734 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 215689005735 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 215689005736 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 215689005737 substrate binding site; other site 215689005738 dimer interface; other site 215689005739 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 215689005740 homotrimer interaction site [polypeptide binding]; other site 215689005741 zinc binding site [ion binding]; other site 215689005742 CDP-binding sites; other site 215689005743 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 215689005744 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 215689005745 Permutation of conserved domain; other site 215689005746 active site 215689005747 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 215689005748 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 215689005749 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 215689005750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689005751 S-adenosylmethionine binding site [chemical binding]; other site 215689005752 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 215689005753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 215689005754 Peptidase family M23; Region: Peptidase_M23; pfam01551 215689005755 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 215689005756 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 215689005757 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689005758 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 215689005759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689005760 DNA binding residues [nucleotide binding] 215689005761 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 215689005762 MutS domain I; Region: MutS_I; pfam01624 215689005763 MutS domain II; Region: MutS_II; pfam05188 215689005764 MutS domain III; Region: MutS_III; pfam05192 215689005765 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 215689005766 Walker A/P-loop; other site 215689005767 ATP binding site [chemical binding]; other site 215689005768 Q-loop/lid; other site 215689005769 ABC transporter signature motif; other site 215689005770 Walker B; other site 215689005771 D-loop; other site 215689005772 H-loop/switch region; other site 215689005773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689005774 Transposase; Region: HTH_Tnp_1; pfam01527 215689005775 HTH-like domain; Region: HTH_21; pfam13276 215689005776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689005777 Integrase core domain; Region: rve; pfam00665 215689005778 Integrase core domain; Region: rve_3; pfam13683 215689005779 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 215689005780 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 215689005781 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 215689005782 TIGR02687 family protein; Region: TIGR02687 215689005783 PglZ domain; Region: PglZ; pfam08665 215689005784 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 215689005785 Methyltransferase domain; Region: Methyltransf_26; pfam13659 215689005786 Methyltransferase domain; Region: Methyltransf_26; pfam13659 215689005787 TIGR02680 family protein; Region: TIGR02680 215689005788 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 215689005789 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 215689005790 Fic/DOC family; Region: Fic; pfam02661 215689005791 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 215689005792 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 215689005793 catalytic residues [active] 215689005794 hinge region; other site 215689005795 alpha helical domain; other site 215689005796 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 215689005797 Transglycosylase SLT domain; Region: SLT_2; pfam13406 215689005798 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689005799 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689005800 catalytic residue [active] 215689005801 hypothetical protein; Validated; Region: PRK03661 215689005802 recombinase A; Provisional; Region: recA; PRK09354 215689005803 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 215689005804 hexamer interface [polypeptide binding]; other site 215689005805 Walker A motif; other site 215689005806 ATP binding site [chemical binding]; other site 215689005807 Walker B motif; other site 215689005808 recombination regulator RecX; Reviewed; Region: recX; PRK00117 215689005809 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 215689005810 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 215689005811 motif 1; other site 215689005812 active site 215689005813 motif 2; other site 215689005814 motif 3; other site 215689005815 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 215689005816 DHHA1 domain; Region: DHHA1; pfam02272 215689005817 carbon storage regulator; Provisional; Region: PRK01712 215689005818 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 215689005819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689005820 motif II; other site 215689005821 Predicted membrane protein [Function unknown]; Region: COG1238 215689005822 glutamate--cysteine ligase; Provisional; Region: PRK02107 215689005823 S-ribosylhomocysteinase; Provisional; Region: PRK02260 215689005824 hypothetical protein; Provisional; Region: PRK11573 215689005825 Domain of unknown function DUF21; Region: DUF21; pfam01595 215689005826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 215689005827 Transporter associated domain; Region: CorC_HlyC; smart01091 215689005828 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 215689005829 signal recognition particle protein; Provisional; Region: PRK10867 215689005830 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 215689005831 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 215689005832 P loop; other site 215689005833 GTP binding site [chemical binding]; other site 215689005834 Signal peptide binding domain; Region: SRP_SPB; pfam02978 215689005835 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 215689005836 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 215689005837 RimM N-terminal domain; Region: RimM; pfam01782 215689005838 PRC-barrel domain; Region: PRC; pfam05239 215689005839 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 215689005840 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 215689005841 PPR repeat family; Region: PPR_2; pfam13041 215689005842 PPR repeat family; Region: PPR_2; pfam13041 215689005843 PPR repeat family; Region: PPR_2; pfam13041 215689005844 PPR repeat family; Region: PPR_2; pfam13041 215689005845 PPR repeat family; Region: PPR_2; pfam13041 215689005846 Pentatricopeptide repeat domain; Region: PPR_3; pfam13812 215689005847 PPR repeat family; Region: PPR_2; pfam13041 215689005848 hypothetical protein; Validated; Region: PRK06186 215689005849 conserved cys residue [active] 215689005850 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 215689005851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 215689005852 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 215689005853 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 215689005854 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 215689005855 Chorismate mutase type II; Region: CM_2; cl00693 215689005856 prephenate dehydrogenase; Validated; Region: PRK08507 215689005857 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 215689005858 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 215689005859 Prephenate dehydratase; Region: PDT; pfam00800 215689005860 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 215689005861 putative L-Phe binding site [chemical binding]; other site 215689005862 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 215689005863 30S subunit binding site; other site 215689005864 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 215689005865 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 215689005866 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689005867 RNA binding surface [nucleotide binding]; other site 215689005868 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 215689005869 active site 215689005870 hypothetical protein; Provisional; Region: PRK10723 215689005871 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 215689005872 protein disaggregation chaperone; Provisional; Region: PRK10865 215689005873 Clp amino terminal domain; Region: Clp_N; pfam02861 215689005874 Clp amino terminal domain; Region: Clp_N; pfam02861 215689005875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689005876 Walker A motif; other site 215689005877 ATP binding site [chemical binding]; other site 215689005878 Walker B motif; other site 215689005879 arginine finger; other site 215689005880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689005881 Walker A motif; other site 215689005882 ATP binding site [chemical binding]; other site 215689005883 Walker B motif; other site 215689005884 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 215689005885 hypothetical protein; Provisional; Region: PRK05421 215689005886 putative catalytic site [active] 215689005887 putative metal binding site [ion binding]; other site 215689005888 putative phosphate binding site [ion binding]; other site 215689005889 putative catalytic site [active] 215689005890 putative phosphate binding site [ion binding]; other site 215689005891 putative metal binding site [ion binding]; other site 215689005892 Methyltransferase domain; Region: Methyltransf_31; pfam13847 215689005893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689005894 S-adenosylmethionine binding site [chemical binding]; other site 215689005895 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 215689005896 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689005897 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689005898 catalytic residue [active] 215689005899 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 215689005900 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 215689005901 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 215689005902 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 215689005903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 215689005904 Methyltransferase domain; Region: Methyltransf_11; pfam08241 215689005905 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 215689005906 RNA/DNA hybrid binding site [nucleotide binding]; other site 215689005907 active site 215689005908 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 215689005909 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 215689005910 active site 215689005911 catalytic site [active] 215689005912 substrate binding site [chemical binding]; other site 215689005913 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 215689005914 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 215689005915 Na binding site [ion binding]; other site 215689005916 putative substrate binding site [chemical binding]; other site 215689005917 Transcriptional regulators [Transcription]; Region: GntR; COG1802 215689005918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689005919 DNA-binding site [nucleotide binding]; DNA binding site 215689005920 FCD domain; Region: FCD; pfam07729 215689005921 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 215689005922 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 215689005923 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 215689005924 active site 215689005925 catalytic site [active] 215689005926 tetramer interface [polypeptide binding]; other site 215689005927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 215689005928 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 215689005929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 215689005930 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 215689005931 DNA methylase; Region: N6_N4_Mtase; pfam01555 215689005932 Uncharacterized conserved protein [Function unknown]; Region: COG4127 215689005933 Restriction endonuclease; Region: Mrr_cat; pfam04471 215689005934 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 215689005935 amidase; Provisional; Region: PRK09201 215689005936 Amidase; Region: Amidase; cl11426 215689005937 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 215689005938 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 215689005939 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 215689005940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689005941 MULE transposase domain; Region: MULE; pfam10551 215689005942 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 215689005943 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 215689005944 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 215689005945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689005946 substrate binding pocket [chemical binding]; other site 215689005947 membrane-bound complex binding site; other site 215689005948 hinge residues; other site 215689005949 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 215689005950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689005951 dimer interface [polypeptide binding]; other site 215689005952 conserved gate region; other site 215689005953 putative PBP binding loops; other site 215689005954 ABC-ATPase subunit interface; other site 215689005955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689005956 dimer interface [polypeptide binding]; other site 215689005957 conserved gate region; other site 215689005958 putative PBP binding loops; other site 215689005959 ABC-ATPase subunit interface; other site 215689005960 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 215689005961 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 215689005962 Walker A/P-loop; other site 215689005963 ATP binding site [chemical binding]; other site 215689005964 Q-loop/lid; other site 215689005965 ABC transporter signature motif; other site 215689005966 Walker B; other site 215689005967 D-loop; other site 215689005968 H-loop/switch region; other site 215689005969 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 215689005970 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689005971 catalytic residue [active] 215689005972 allantoate amidohydrolase; Reviewed; Region: PRK09290 215689005973 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 215689005974 active site 215689005975 metal binding site [ion binding]; metal-binding site 215689005976 dimer interface [polypeptide binding]; other site 215689005977 OHCU decarboxylase; Region: UraD_2; TIGR03180 215689005978 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 215689005979 active site 215689005980 homotetramer interface [polypeptide binding]; other site 215689005981 xanthine permease; Region: pbuX; TIGR03173 215689005982 C-N hydrolase family amidase; Provisional; Region: PRK10438 215689005983 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 215689005984 putative active site [active] 215689005985 catalytic triad [active] 215689005986 dimer interface [polypeptide binding]; other site 215689005987 multimer interface [polypeptide binding]; other site 215689005988 methionine aminotransferase; Validated; Region: PRK09082 215689005989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689005990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689005991 homodimer interface [polypeptide binding]; other site 215689005992 catalytic residue [active] 215689005993 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 215689005994 intersubunit interface [polypeptide binding]; other site 215689005995 active site 215689005996 Zn2+ binding site [ion binding]; other site 215689005997 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 215689005998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689005999 motif II; other site 215689006000 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 215689006001 Cupin domain; Region: Cupin_2; cl17218 215689006002 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 215689006003 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 215689006004 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 215689006005 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 215689006006 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 215689006007 active site 215689006008 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 215689006009 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 215689006010 dimer interface [polypeptide binding]; other site 215689006011 active site 215689006012 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 215689006013 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 215689006014 putative active site [active] 215689006015 putative dimer interface [polypeptide binding]; other site 215689006016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 215689006017 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 215689006018 active site 215689006019 DNA polymerase IV; Validated; Region: PRK02406 215689006020 DNA binding site [nucleotide binding] 215689006021 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 215689006022 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 215689006023 metal binding site [ion binding]; metal-binding site 215689006024 dimer interface [polypeptide binding]; other site 215689006025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689006026 active site 215689006027 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 215689006028 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 215689006029 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 215689006030 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 215689006031 trimer interface [polypeptide binding]; other site 215689006032 eyelet of channel; other site 215689006033 gamma-glutamyl kinase; Provisional; Region: PRK05429 215689006034 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 215689006035 nucleotide binding site [chemical binding]; other site 215689006036 homotetrameric interface [polypeptide binding]; other site 215689006037 putative phosphate binding site [ion binding]; other site 215689006038 putative allosteric binding site; other site 215689006039 PUA domain; Region: PUA; pfam01472 215689006040 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 215689006041 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 215689006042 putative catalytic cysteine [active] 215689006043 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 215689006044 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 215689006045 oligomeric interface; other site 215689006046 putative active site [active] 215689006047 homodimer interface [polypeptide binding]; other site 215689006048 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 215689006049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 215689006050 chromosome condensation membrane protein; Provisional; Region: PRK14196 215689006051 anti-RssB factor; Provisional; Region: PRK10244 215689006052 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 215689006053 Acyltransferase family; Region: Acyl_transf_3; pfam01757 215689006054 KTSC domain; Region: KTSC; pfam13619 215689006055 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 215689006056 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 215689006057 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689006058 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 215689006059 Walker A/P-loop; other site 215689006060 ATP binding site [chemical binding]; other site 215689006061 Q-loop/lid; other site 215689006062 ABC transporter signature motif; other site 215689006063 Walker B; other site 215689006064 D-loop; other site 215689006065 H-loop/switch region; other site 215689006066 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 215689006067 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689006068 Walker A/P-loop; other site 215689006069 ATP binding site [chemical binding]; other site 215689006070 Q-loop/lid; other site 215689006071 ABC transporter signature motif; other site 215689006072 Walker B; other site 215689006073 D-loop; other site 215689006074 H-loop/switch region; other site 215689006075 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 215689006076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689006077 dimer interface [polypeptide binding]; other site 215689006078 conserved gate region; other site 215689006079 putative PBP binding loops; other site 215689006080 ABC-ATPase subunit interface; other site 215689006081 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 215689006082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689006083 putative PBP binding loops; other site 215689006084 dimer interface [polypeptide binding]; other site 215689006085 ABC-ATPase subunit interface; other site 215689006086 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 215689006087 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 215689006088 CAAX protease self-immunity; Region: Abi; pfam02517 215689006089 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 215689006090 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 215689006091 DNA-binding site [nucleotide binding]; DNA binding site 215689006092 RNA-binding motif; other site 215689006093 potential frameshift: common BLAST hit: gi|292487398|ref|YP_003530270.1| beta-galactosidase 215689006094 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 215689006095 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 215689006096 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 215689006097 potential frameshift: common BLAST hit: gi|292898645|ref|YP_003538014.1| beta-galactosidase 215689006098 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 215689006099 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 215689006100 psiF repeat; Region: PsiF_repeat; pfam07769 215689006101 psiF repeat; Region: PsiF_repeat; pfam07769 215689006102 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 215689006103 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 215689006104 pyrroline-5-carboxylate reductase; Region: PLN02688 215689006105 hypothetical protein; Validated; Region: PRK00124 215689006106 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 215689006107 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 215689006108 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 215689006109 ADP binding site [chemical binding]; other site 215689006110 magnesium binding site [ion binding]; other site 215689006111 putative shikimate binding site; other site 215689006112 hypothetical protein; Provisional; Region: PRK10380 215689006113 AroM protein; Region: AroM; cl17601 215689006114 hypothetical protein; Provisional; Region: PRK10579 215689006115 recombination associated protein; Reviewed; Region: rdgC; PRK00321 215689006116 ethanolamine permease; Region: 2A0305; TIGR00908 215689006117 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 215689006118 active site 215689006119 substrate binding site [chemical binding]; other site 215689006120 Phosphotransferase enzyme family; Region: APH; pfam01636 215689006121 ATP binding site [chemical binding]; other site 215689006122 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 215689006123 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 215689006124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689006125 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 215689006126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689006127 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 215689006128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 215689006129 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 215689006130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689006131 AAA domain; Region: AAA_23; pfam13476 215689006132 Walker A/P-loop; other site 215689006133 ATP binding site [chemical binding]; other site 215689006134 Q-loop/lid; other site 215689006135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689006136 ABC transporter signature motif; other site 215689006137 Walker B; other site 215689006138 D-loop; other site 215689006139 H-loop/switch region; other site 215689006140 exonuclease subunit SbcD; Provisional; Region: PRK10966 215689006141 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 215689006142 active site 215689006143 metal binding site [ion binding]; metal-binding site 215689006144 DNA binding site [nucleotide binding] 215689006145 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 215689006146 transcriptional regulator PhoB; Provisional; Region: PRK10161 215689006147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689006148 active site 215689006149 phosphorylation site [posttranslational modification] 215689006150 intermolecular recognition site; other site 215689006151 dimerization interface [polypeptide binding]; other site 215689006152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689006153 DNA binding site [nucleotide binding] 215689006154 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 215689006155 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 215689006156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 215689006157 putative active site [active] 215689006158 heme pocket [chemical binding]; other site 215689006159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689006160 dimer interface [polypeptide binding]; other site 215689006161 phosphorylation site [posttranslational modification] 215689006162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689006163 ATP binding site [chemical binding]; other site 215689006164 Mg2+ binding site [ion binding]; other site 215689006165 G-X-G motif; other site 215689006166 PBP superfamily domain; Region: PBP_like_2; cl17296 215689006167 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 215689006168 substrate binding site [chemical binding]; other site 215689006169 THF binding site; other site 215689006170 zinc-binding site [ion binding]; other site 215689006171 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 215689006172 putative proline-specific permease; Provisional; Region: proY; PRK10580 215689006173 Spore germination protein; Region: Spore_permease; cl17796 215689006174 peroxidase; Provisional; Region: PRK15000 215689006175 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 215689006176 dimer interface [polypeptide binding]; other site 215689006177 decamer (pentamer of dimers) interface [polypeptide binding]; other site 215689006178 catalytic triad [active] 215689006179 peroxidatic and resolving cysteines [active] 215689006180 Protein of unknown function, DUF479; Region: DUF479; cl01203 215689006181 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 215689006182 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 215689006183 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 215689006184 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 215689006185 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 215689006186 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 215689006187 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 215689006188 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 215689006189 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 215689006190 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 215689006191 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 215689006192 Protein export membrane protein; Region: SecD_SecF; pfam02355 215689006193 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 215689006194 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 215689006195 BON domain; Region: BON; pfam04972 215689006196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 215689006197 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 215689006198 ATP cone domain; Region: ATP-cone; pfam03477 215689006199 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 215689006200 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 215689006201 catalytic motif [active] 215689006202 Zn binding site [ion binding]; other site 215689006203 RibD C-terminal domain; Region: RibD_C; cl17279 215689006204 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 215689006205 homopentamer interface [polypeptide binding]; other site 215689006206 active site 215689006207 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 215689006208 putative RNA binding site [nucleotide binding]; other site 215689006209 thiamine monophosphate kinase; Provisional; Region: PRK05731 215689006210 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 215689006211 ATP binding site [chemical binding]; other site 215689006212 dimerization interface [polypeptide binding]; other site 215689006213 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 215689006214 tetramer interfaces [polypeptide binding]; other site 215689006215 binuclear metal-binding site [ion binding]; other site 215689006216 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 215689006217 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 215689006218 TPP-binding site; other site 215689006219 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 215689006220 PYR/PP interface [polypeptide binding]; other site 215689006221 dimer interface [polypeptide binding]; other site 215689006222 TPP binding site [chemical binding]; other site 215689006223 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 215689006224 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 215689006225 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 215689006226 substrate binding pocket [chemical binding]; other site 215689006227 chain length determination region; other site 215689006228 substrate-Mg2+ binding site; other site 215689006229 catalytic residues [active] 215689006230 aspartate-rich region 1; other site 215689006231 active site lid residues [active] 215689006232 aspartate-rich region 2; other site 215689006233 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 215689006234 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 215689006235 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 215689006236 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 215689006237 Ligand Binding Site [chemical binding]; other site 215689006238 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 215689006239 active site residue [active] 215689006240 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 215689006241 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 215689006242 conserved cys residue [active] 215689006243 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 215689006244 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 215689006245 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 215689006246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 215689006247 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 215689006248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689006249 Integrase core domain; Region: rve; pfam00665 215689006250 Integrase core domain; Region: rve_3; pfam13683 215689006251 Transposase; Region: HTH_Tnp_1; pfam01527 215689006252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689006253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 215689006254 putative substrate translocation pore; other site 215689006255 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 215689006256 UbiA prenyltransferase family; Region: UbiA; pfam01040 215689006257 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 215689006258 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 215689006259 Subunit I/III interface [polypeptide binding]; other site 215689006260 Subunit III/IV interface [polypeptide binding]; other site 215689006261 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 215689006262 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 215689006263 D-pathway; other site 215689006264 Putative ubiquinol binding site [chemical binding]; other site 215689006265 Low-spin heme (heme b) binding site [chemical binding]; other site 215689006266 Putative water exit pathway; other site 215689006267 Binuclear center (heme o3/CuB) [ion binding]; other site 215689006268 K-pathway; other site 215689006269 Putative proton exit pathway; other site 215689006270 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 215689006271 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 215689006272 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 215689006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689006274 putative substrate translocation pore; other site 215689006275 hypothetical protein; Provisional; Region: PRK11627 215689006276 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 215689006277 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 215689006278 transcriptional regulator BolA; Provisional; Region: PRK11628 215689006279 trigger factor; Provisional; Region: tig; PRK01490 215689006280 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 215689006281 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 215689006282 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 215689006283 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 215689006284 oligomer interface [polypeptide binding]; other site 215689006285 active site residues [active] 215689006286 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 215689006287 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 215689006288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689006289 Walker A motif; other site 215689006290 ATP binding site [chemical binding]; other site 215689006291 Walker B motif; other site 215689006292 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 215689006293 Clp protease; Region: CLP_protease; pfam00574 215689006294 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 215689006295 oligomer interface [polypeptide binding]; other site 215689006296 active site residues [active] 215689006297 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 215689006298 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 215689006299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689006300 Walker A motif; other site 215689006301 ATP binding site [chemical binding]; other site 215689006302 Walker B motif; other site 215689006303 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 215689006304 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 215689006305 Found in ATP-dependent protease La (LON); Region: LON; smart00464 215689006306 Found in ATP-dependent protease La (LON); Region: LON; smart00464 215689006307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689006308 Walker A motif; other site 215689006309 ATP binding site [chemical binding]; other site 215689006310 Walker B motif; other site 215689006311 arginine finger; other site 215689006312 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 215689006313 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 215689006314 IHF dimer interface [polypeptide binding]; other site 215689006315 IHF - DNA interface [nucleotide binding]; other site 215689006316 periplasmic folding chaperone; Provisional; Region: PRK10788 215689006317 SurA N-terminal domain; Region: SurA_N_3; cl07813 215689006318 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 215689006319 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 215689006320 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 215689006321 active site 215689006322 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 215689006323 Ligand Binding Site [chemical binding]; other site 215689006324 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 215689006325 EamA-like transporter family; Region: EamA; pfam00892 215689006326 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 215689006327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 215689006328 putative DNA binding site [nucleotide binding]; other site 215689006329 putative Zn2+ binding site [ion binding]; other site 215689006330 AsnC family; Region: AsnC_trans_reg; pfam01037 215689006331 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 215689006332 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 215689006333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689006334 Walker A/P-loop; other site 215689006335 ATP binding site [chemical binding]; other site 215689006336 Q-loop/lid; other site 215689006337 ABC transporter signature motif; other site 215689006338 Walker B; other site 215689006339 D-loop; other site 215689006340 H-loop/switch region; other site 215689006341 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 215689006342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 215689006343 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 215689006344 Walker A/P-loop; other site 215689006345 ATP binding site [chemical binding]; other site 215689006346 Q-loop/lid; other site 215689006347 ABC transporter signature motif; other site 215689006348 Walker B; other site 215689006349 D-loop; other site 215689006350 H-loop/switch region; other site 215689006351 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 215689006352 Nitrogen regulatory protein P-II; Region: P-II; smart00938 215689006353 ammonium transporter; Provisional; Region: PRK10666 215689006354 acyl-CoA thioesterase II; Provisional; Region: PRK10526 215689006355 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 215689006356 active site 215689006357 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 215689006358 catalytic triad [active] 215689006359 dimer interface [polypeptide binding]; other site 215689006360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 215689006361 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 215689006362 DNA binding site [nucleotide binding] 215689006363 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 215689006364 active site 215689006365 Haemolysin expression modulating protein; Region: HHA; cl11501 215689006366 Hha toxicity attenuator; Provisional; Region: PRK10667 215689006367 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 215689006368 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 215689006369 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 215689006370 Protein export membrane protein; Region: SecD_SecF; cl14618 215689006371 Protein export membrane protein; Region: SecD_SecF; cl14618 215689006372 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 215689006373 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 215689006374 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689006375 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 215689006376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689006377 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 215689006378 hypothetical protein; Provisional; Region: PRK11038 215689006379 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 215689006380 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 215689006381 hypothetical protein; Provisional; Region: PRK10527 215689006382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689006383 active site 215689006384 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 215689006385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689006386 Walker A motif; other site 215689006387 ATP binding site [chemical binding]; other site 215689006388 Walker B motif; other site 215689006389 arginine finger; other site 215689006390 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 215689006391 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 215689006392 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 215689006393 hypothetical protein; Validated; Region: PRK00153 215689006394 recombination protein RecR; Reviewed; Region: recR; PRK00076 215689006395 RecR protein; Region: RecR; pfam02132 215689006396 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 215689006397 putative active site [active] 215689006398 putative metal-binding site [ion binding]; other site 215689006399 tetramer interface [polypeptide binding]; other site 215689006400 heat shock protein 90; Provisional; Region: PRK05218 215689006401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689006402 ATP binding site [chemical binding]; other site 215689006403 Mg2+ binding site [ion binding]; other site 215689006404 G-X-G motif; other site 215689006405 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 215689006406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689006407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 215689006408 dimerization interface [polypeptide binding]; other site 215689006409 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 215689006410 nudix motif; other site 215689006411 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 215689006412 adenylate kinase; Reviewed; Region: adk; PRK00279 215689006413 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 215689006414 AMP-binding site [chemical binding]; other site 215689006415 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 215689006416 ferrochelatase; Reviewed; Region: hemH; PRK00035 215689006417 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 215689006418 C-terminal domain interface [polypeptide binding]; other site 215689006419 active site 215689006420 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 215689006421 active site 215689006422 N-terminal domain interface [polypeptide binding]; other site 215689006423 inosine/guanosine kinase; Provisional; Region: PRK15074 215689006424 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 215689006425 putative cation:proton antiport protein; Provisional; Region: PRK10669 215689006426 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 215689006427 TrkA-N domain; Region: TrkA_N; pfam02254 215689006428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689006429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 215689006430 putative substrate translocation pore; other site 215689006431 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 215689006432 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 215689006433 active site 215689006434 metal binding site [ion binding]; metal-binding site 215689006435 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 215689006436 Predicted membrane protein [Function unknown]; Region: COG4125 215689006437 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 215689006438 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 215689006439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689006440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689006441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 215689006442 dimerization interface [polypeptide binding]; other site 215689006443 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 215689006444 putative deacylase active site [active] 215689006445 TraB family; Region: TraB; cl12050 215689006446 copper exporting ATPase; Provisional; Region: copA; PRK10671 215689006447 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 215689006448 metal-binding site [ion binding] 215689006449 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 215689006450 metal-binding site [ion binding] 215689006451 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 215689006452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689006453 motif II; other site 215689006454 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 215689006455 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 215689006456 DNA binding residues [nucleotide binding] 215689006457 dimer interface [polypeptide binding]; other site 215689006458 copper binding site [ion binding]; other site 215689006459 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 215689006460 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 215689006461 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 215689006462 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 215689006463 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 215689006464 oxidoreductase; Provisional; Region: PRK08017 215689006465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 215689006466 NAD(P) binding site [chemical binding]; other site 215689006467 active site 215689006468 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 215689006469 active site 215689006470 catalytic triad [active] 215689006471 oxyanion hole [active] 215689006472 switch loop; other site 215689006473 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 215689006474 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 215689006475 Walker A/P-loop; other site 215689006476 ATP binding site [chemical binding]; other site 215689006477 Q-loop/lid; other site 215689006478 ABC transporter signature motif; other site 215689006479 Walker B; other site 215689006480 D-loop; other site 215689006481 H-loop/switch region; other site 215689006482 FtsX-like permease family; Region: FtsX; pfam02687 215689006483 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 215689006484 ATP-grasp domain; Region: ATP-grasp; pfam02222 215689006485 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 215689006486 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 215689006487 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 215689006488 putative active site [active] 215689006489 putative metal binding site [ion binding]; other site 215689006490 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 215689006491 substrate binding site [chemical binding]; other site 215689006492 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 215689006493 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 215689006494 active site 215689006495 HIGH motif; other site 215689006496 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 215689006497 KMSKS motif; other site 215689006498 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 215689006499 tRNA binding surface [nucleotide binding]; other site 215689006500 anticodon binding site; other site 215689006501 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 215689006502 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 215689006503 NAD binding site [chemical binding]; other site 215689006504 substrate binding site [chemical binding]; other site 215689006505 catalytic Zn binding site [ion binding]; other site 215689006506 tetramer interface [polypeptide binding]; other site 215689006507 structural Zn binding site [ion binding]; other site 215689006508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689006509 RNA binding surface [nucleotide binding]; other site 215689006510 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 215689006511 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 215689006512 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 215689006513 homodimer interface [polypeptide binding]; other site 215689006514 NADP binding site [chemical binding]; other site 215689006515 substrate binding site [chemical binding]; other site 215689006516 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 215689006517 Int/Topo IB signature motif; other site 215689006518 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689006519 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 215689006520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689006521 Transposase; Region: HTH_Tnp_1; pfam01527 215689006522 HTH-like domain; Region: HTH_21; pfam13276 215689006523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689006524 Integrase core domain; Region: rve; pfam00665 215689006525 Integrase core domain; Region: rve_3; pfam13683 215689006526 Transposase; Region: HTH_Tnp_1; pfam01527 215689006527 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 215689006528 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 215689006529 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 215689006530 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 215689006531 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 215689006532 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 215689006533 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 215689006534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 215689006535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689006536 dimer interface [polypeptide binding]; other site 215689006537 conserved gate region; other site 215689006538 putative PBP binding loops; other site 215689006539 ABC-ATPase subunit interface; other site 215689006540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 215689006541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689006542 dimer interface [polypeptide binding]; other site 215689006543 conserved gate region; other site 215689006544 ABC-ATPase subunit interface; other site 215689006545 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 215689006546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689006547 Walker A/P-loop; other site 215689006548 ATP binding site [chemical binding]; other site 215689006549 Q-loop/lid; other site 215689006550 ABC transporter signature motif; other site 215689006551 Walker B; other site 215689006552 D-loop; other site 215689006553 H-loop/switch region; other site 215689006554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689006555 Walker A/P-loop; other site 215689006556 ATP binding site [chemical binding]; other site 215689006557 Q-loop/lid; other site 215689006558 ABC transporter signature motif; other site 215689006559 Walker B; other site 215689006560 D-loop; other site 215689006561 H-loop/switch region; other site 215689006562 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 215689006563 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 215689006564 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 215689006565 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 215689006566 N-terminal plug; other site 215689006567 ligand-binding site [chemical binding]; other site 215689006568 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 215689006569 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 215689006570 Trp docking motif [polypeptide binding]; other site 215689006571 putative active site [active] 215689006572 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 215689006573 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 215689006574 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 215689006575 inhibitor-cofactor binding pocket; inhibition site 215689006576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689006577 catalytic residue [active] 215689006578 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 215689006579 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 215689006580 Ligand binding site; other site 215689006581 Putative Catalytic site; other site 215689006582 DXD motif; other site 215689006583 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 215689006584 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 215689006585 active site 215689006586 substrate binding site [chemical binding]; other site 215689006587 cosubstrate binding site; other site 215689006588 catalytic site [active] 215689006589 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 215689006590 active site 215689006591 hexamer interface [polypeptide binding]; other site 215689006592 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 215689006593 NAD binding site [chemical binding]; other site 215689006594 substrate binding site [chemical binding]; other site 215689006595 active site 215689006596 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 215689006597 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 215689006598 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 215689006599 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 215689006600 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 215689006601 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 215689006602 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 215689006603 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 215689006604 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 215689006605 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 215689006606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689006607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689006608 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 215689006609 putative effector binding pocket; other site 215689006610 putative dimerization interface [polypeptide binding]; other site 215689006611 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 215689006612 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 215689006613 putative NAD(P) binding site [chemical binding]; other site 215689006614 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 215689006615 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 215689006616 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 215689006617 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 215689006618 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 215689006619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 215689006620 putative aldolase; Validated; Region: PRK08130 215689006621 intersubunit interface [polypeptide binding]; other site 215689006622 active site 215689006623 Zn2+ binding site [ion binding]; other site 215689006624 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 215689006625 putative transporter; Provisional; Region: PRK09821 215689006626 GntP family permease; Region: GntP_permease; pfam02447 215689006627 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 215689006628 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 215689006629 DNA-binding site [nucleotide binding]; DNA binding site 215689006630 RNA-binding motif; other site 215689006631 Predicted amidohydrolase [General function prediction only]; Region: COG0388 215689006632 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 215689006633 putative active site [active] 215689006634 catalytic triad [active] 215689006635 putative dimer interface [polypeptide binding]; other site 215689006636 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 215689006637 lipoyl synthase; Provisional; Region: PRK05481 215689006638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689006639 FeS/SAM binding site; other site 215689006640 lipoate-protein ligase B; Provisional; Region: PRK14342 215689006641 hypothetical protein; Provisional; Region: PRK04998 215689006642 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 215689006643 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 215689006644 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 215689006645 rare lipoprotein A; Provisional; Region: PRK10672 215689006646 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 215689006647 Sporulation related domain; Region: SPOR; pfam05036 215689006648 cell wall shape-determining protein; Provisional; Region: PRK10794 215689006649 penicillin-binding protein 2; Provisional; Region: PRK10795 215689006650 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 215689006651 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 215689006652 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 215689006653 ribosome-associated protein; Provisional; Region: PRK11538 215689006654 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 215689006655 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 215689006656 active site 215689006657 (T/H)XGH motif; other site 215689006658 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 215689006659 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 215689006660 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 215689006661 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 215689006662 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 215689006663 HIGH motif; other site 215689006664 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 215689006665 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 215689006666 active site 215689006667 KMSKS motif; other site 215689006668 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 215689006669 tRNA binding surface [nucleotide binding]; other site 215689006670 hypothetical protein; Provisional; Region: PRK11032 215689006671 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 215689006672 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 215689006673 Walker A/P-loop; other site 215689006674 ATP binding site [chemical binding]; other site 215689006675 Q-loop/lid; other site 215689006676 ABC transporter signature motif; other site 215689006677 Walker B; other site 215689006678 D-loop; other site 215689006679 H-loop/switch region; other site 215689006680 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 215689006681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689006682 dimer interface [polypeptide binding]; other site 215689006683 conserved gate region; other site 215689006684 putative PBP binding loops; other site 215689006685 ABC-ATPase subunit interface; other site 215689006686 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 215689006687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689006688 dimer interface [polypeptide binding]; other site 215689006689 conserved gate region; other site 215689006690 putative PBP binding loops; other site 215689006691 ABC-ATPase subunit interface; other site 215689006692 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 215689006693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689006694 substrate binding pocket [chemical binding]; other site 215689006695 membrane-bound complex binding site; other site 215689006696 hinge residues; other site 215689006697 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 215689006698 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 215689006699 putative active site [active] 215689006700 catalytic triad [active] 215689006701 putative dimer interface [polypeptide binding]; other site 215689006702 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 215689006703 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 215689006704 Transporter associated domain; Region: CorC_HlyC; smart01091 215689006705 metal-binding heat shock protein; Provisional; Region: PRK00016 215689006706 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 215689006707 PhoH-like protein; Region: PhoH; pfam02562 215689006708 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 215689006709 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 215689006710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689006711 FeS/SAM binding site; other site 215689006712 TRAM domain; Region: TRAM; pfam01938 215689006713 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 215689006714 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 215689006715 asparagine synthetase B; Provisional; Region: asnB; PRK09431 215689006716 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 215689006717 active site 215689006718 dimer interface [polypeptide binding]; other site 215689006719 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 215689006720 Ligand Binding Site [chemical binding]; other site 215689006721 Molecular Tunnel; other site 215689006722 UMP phosphatase; Provisional; Region: PRK10444 215689006723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689006724 active site 215689006725 motif I; other site 215689006726 motif II; other site 215689006727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689006728 MarR family; Region: MarR; pfam01047 215689006729 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 215689006730 ROK family; Region: ROK; pfam00480 215689006731 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 215689006732 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 215689006733 active site 215689006734 dimer interface [polypeptide binding]; other site 215689006735 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 215689006736 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 215689006737 active site 215689006738 trimer interface [polypeptide binding]; other site 215689006739 allosteric site; other site 215689006740 active site lid [active] 215689006741 hexamer (dimer of trimers) interface [polypeptide binding]; other site 215689006742 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 215689006743 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 215689006744 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 215689006745 active site turn [active] 215689006746 phosphorylation site [posttranslational modification] 215689006747 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 215689006748 HPr interaction site; other site 215689006749 glycerol kinase (GK) interaction site [polypeptide binding]; other site 215689006750 active site 215689006751 phosphorylation site [posttranslational modification] 215689006752 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 215689006753 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 215689006754 active site 215689006755 HIGH motif; other site 215689006756 nucleotide binding site [chemical binding]; other site 215689006757 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 215689006758 KMSKS motif; other site 215689006759 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 215689006760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 215689006761 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 215689006762 aromatic amino acid transport protein; Region: araaP; TIGR00837 215689006763 ferric uptake regulator; Provisional; Region: fur; PRK09462 215689006764 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 215689006765 metal binding site 2 [ion binding]; metal-binding site 215689006766 putative DNA binding helix; other site 215689006767 metal binding site 1 [ion binding]; metal-binding site 215689006768 dimer interface [polypeptide binding]; other site 215689006769 structural Zn2+ binding site [ion binding]; other site 215689006770 flavodoxin FldA; Validated; Region: PRK09267 215689006771 LexA regulated protein; Provisional; Region: PRK11675 215689006772 acyl-CoA esterase; Provisional; Region: PRK10673 215689006773 PGAP1-like protein; Region: PGAP1; pfam07819 215689006774 replication initiation regulator SeqA; Provisional; Region: PRK11187 215689006775 phosphoglucomutase; Validated; Region: PRK07564 215689006776 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 215689006777 active site 215689006778 substrate binding site [chemical binding]; other site 215689006779 metal binding site [ion binding]; metal-binding site 215689006780 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 215689006781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689006782 active site 215689006783 phosphorylation site [posttranslational modification] 215689006784 intermolecular recognition site; other site 215689006785 dimerization interface [polypeptide binding]; other site 215689006786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689006787 DNA binding site [nucleotide binding] 215689006788 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 215689006789 Protein of unknown function (DUF523); Region: DUF523; pfam04463 215689006790 Uncharacterized conserved protein [Function unknown]; Region: COG3272 215689006791 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 215689006792 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 215689006793 DNA photolyase; Region: DNA_photolyase; pfam00875 215689006794 Uncharacterized conserved protein [Function unknown]; Region: COG0327 215689006795 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 215689006796 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 215689006797 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 215689006798 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 215689006799 LamB/YcsF family protein; Provisional; Region: PRK05406 215689006800 Protein of unknown function (DUF969); Region: DUF969; pfam06149 215689006801 Predicted membrane protein [Function unknown]; Region: COG3817 215689006802 Protein of unknown function (DUF979); Region: DUF979; pfam06166 215689006803 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 215689006804 putative substrate binding pocket [chemical binding]; other site 215689006805 AC domain interface; other site 215689006806 catalytic triad [active] 215689006807 AB domain interface; other site 215689006808 interchain disulfide; other site 215689006809 endonuclease VIII; Provisional; Region: PRK10445 215689006810 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 215689006811 DNA binding site [nucleotide binding] 215689006812 catalytic residue [active] 215689006813 H2TH interface [polypeptide binding]; other site 215689006814 putative catalytic residues [active] 215689006815 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 215689006816 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 215689006817 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 215689006818 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 215689006819 dimer interface [polypeptide binding]; other site 215689006820 active site 215689006821 citrylCoA binding site [chemical binding]; other site 215689006822 NADH binding [chemical binding]; other site 215689006823 cationic pore residues; other site 215689006824 oxalacetate/citrate binding site [chemical binding]; other site 215689006825 coenzyme A binding site [chemical binding]; other site 215689006826 catalytic triad [active] 215689006827 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 215689006828 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 215689006829 SdhC subunit interface [polypeptide binding]; other site 215689006830 proximal heme binding site [chemical binding]; other site 215689006831 cardiolipin binding site; other site 215689006832 Iron-sulfur protein interface; other site 215689006833 proximal quinone binding site [chemical binding]; other site 215689006834 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 215689006835 L-aspartate oxidase; Provisional; Region: PRK06175 215689006836 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 215689006837 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 215689006838 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 215689006839 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 215689006840 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 215689006841 TPP-binding site [chemical binding]; other site 215689006842 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 215689006843 dimer interface [polypeptide binding]; other site 215689006844 PYR/PP interface [polypeptide binding]; other site 215689006845 TPP binding site [chemical binding]; other site 215689006846 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 215689006847 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 215689006848 E3 interaction surface; other site 215689006849 lipoyl attachment site [posttranslational modification]; other site 215689006850 e3 binding domain; Region: E3_binding; pfam02817 215689006851 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 215689006852 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 215689006853 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 215689006854 CoA-ligase; Region: Ligase_CoA; pfam00549 215689006855 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 215689006856 CoA binding domain; Region: CoA_binding; pfam02629 215689006857 CoA-ligase; Region: Ligase_CoA; pfam00549 215689006858 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 215689006859 active site 215689006860 colicin uptake protein TolQ; Provisional; Region: PRK10801 215689006861 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 215689006862 colicin uptake protein TolR; Provisional; Region: PRK11024 215689006863 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 215689006864 TolA C-terminal; Region: TolA; pfam06519 215689006865 translocation protein TolB; Provisional; Region: tolB; PRK03629 215689006866 TolB amino-terminal domain; Region: TolB_N; pfam04052 215689006867 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 215689006868 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 215689006869 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 215689006870 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 215689006871 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 215689006872 ligand binding site [chemical binding]; other site 215689006873 tol-pal system protein YbgF; Provisional; Region: PRK10803 215689006874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 215689006875 TPR motif; other site 215689006876 binding surface 215689006877 Helix-turn-helix domain; Region: HTH_18; pfam12833 215689006878 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 215689006879 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 215689006880 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 215689006881 DNA binding site [nucleotide binding] 215689006882 active site 215689006883 quinolinate synthetase; Provisional; Region: PRK09375 215689006884 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 215689006885 zinc transporter ZitB; Provisional; Region: PRK03557 215689006886 YbgS-like protein; Region: YbgS; pfam13985 215689006887 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 215689006888 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 215689006889 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689006890 RHS Repeat; Region: RHS_repeat; pfam05593 215689006891 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689006892 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 215689006893 catalytic core [active] 215689006894 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 215689006895 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 215689006896 active site 215689006897 catalytic residues [active] 215689006898 galactokinase; Provisional; Region: PRK05101 215689006899 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 215689006900 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 215689006901 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 215689006902 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 215689006903 dimer interface [polypeptide binding]; other site 215689006904 active site 215689006905 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 215689006906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689006907 Walker A/P-loop; other site 215689006908 ATP binding site [chemical binding]; other site 215689006909 ABC transporter signature motif; other site 215689006910 Walker B; other site 215689006911 D-loop; other site 215689006912 H-loop/switch region; other site 215689006913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689006914 Walker A/P-loop; other site 215689006915 ATP binding site [chemical binding]; other site 215689006916 Q-loop/lid; other site 215689006917 ABC transporter signature motif; other site 215689006918 Walker B; other site 215689006919 D-loop; other site 215689006920 H-loop/switch region; other site 215689006921 HTH-like domain; Region: HTH_21; pfam13276 215689006922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689006923 Integrase core domain; Region: rve; pfam00665 215689006924 Integrase core domain; Region: rve_3; pfam13683 215689006925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689006926 Transposase; Region: HTH_Tnp_1; pfam01527 215689006927 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 215689006928 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 215689006929 molybdenum-pterin binding domain; Region: Mop; TIGR00638 215689006930 TOBE domain; Region: TOBE; cl01440 215689006931 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 215689006932 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 215689006933 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 215689006934 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 215689006935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689006936 dimer interface [polypeptide binding]; other site 215689006937 conserved gate region; other site 215689006938 putative PBP binding loops; other site 215689006939 ABC-ATPase subunit interface; other site 215689006940 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 215689006941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689006942 Walker A/P-loop; other site 215689006943 ATP binding site [chemical binding]; other site 215689006944 Q-loop/lid; other site 215689006945 ABC transporter signature motif; other site 215689006946 Walker B; other site 215689006947 D-loop; other site 215689006948 H-loop/switch region; other site 215689006949 TOBE domain; Region: TOBE; pfam03459 215689006950 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 215689006951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689006952 active site 215689006953 motif I; other site 215689006954 motif II; other site 215689006955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689006956 6-phosphogluconolactonase; Provisional; Region: PRK11028 215689006957 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 215689006958 substrate binding site [chemical binding]; other site 215689006959 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 215689006960 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 215689006961 inhibitor-cofactor binding pocket; inhibition site 215689006962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689006963 catalytic residue [active] 215689006964 biotin synthase; Provisional; Region: PRK15108 215689006965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689006966 FeS/SAM binding site; other site 215689006967 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 215689006968 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 215689006969 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 215689006970 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689006971 catalytic residue [active] 215689006972 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 215689006973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689006974 S-adenosylmethionine binding site [chemical binding]; other site 215689006975 AAA domain; Region: AAA_26; pfam13500 215689006976 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 215689006977 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 215689006978 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 215689006979 Walker A/P-loop; other site 215689006980 ATP binding site [chemical binding]; other site 215689006981 Q-loop/lid; other site 215689006982 ABC transporter signature motif; other site 215689006983 Walker B; other site 215689006984 D-loop; other site 215689006985 H-loop/switch region; other site 215689006986 excinuclease ABC subunit B; Provisional; Region: PRK05298 215689006987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689006988 ATP binding site [chemical binding]; other site 215689006989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689006990 nucleotide binding region [chemical binding]; other site 215689006991 ATP-binding site [chemical binding]; other site 215689006992 Ultra-violet resistance protein B; Region: UvrB; pfam12344 215689006993 UvrB/uvrC motif; Region: UVR; pfam02151 215689006994 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 215689006995 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 215689006996 phosphate binding site [ion binding]; other site 215689006997 putative substrate binding pocket [chemical binding]; other site 215689006998 dimer interface [polypeptide binding]; other site 215689006999 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 215689007000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 215689007001 FeS/SAM binding site; other site 215689007002 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 215689007003 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 215689007004 MPT binding site; other site 215689007005 trimer interface [polypeptide binding]; other site 215689007006 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 215689007007 trimer interface [polypeptide binding]; other site 215689007008 dimer interface [polypeptide binding]; other site 215689007009 putative active site [active] 215689007010 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 215689007011 MoaE interaction surface [polypeptide binding]; other site 215689007012 MoeB interaction surface [polypeptide binding]; other site 215689007013 thiocarboxylated glycine; other site 215689007014 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 215689007015 MoaE homodimer interface [polypeptide binding]; other site 215689007016 MoaD interaction [polypeptide binding]; other site 215689007017 active site residues [active] 215689007018 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 215689007019 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 215689007020 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 215689007021 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 215689007022 helicase 45; Provisional; Region: PTZ00424 215689007023 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 215689007024 ATP binding site [chemical binding]; other site 215689007025 Mg++ binding site [ion binding]; other site 215689007026 motif III; other site 215689007027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689007028 nucleotide binding region [chemical binding]; other site 215689007029 ATP-binding site [chemical binding]; other site 215689007030 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 215689007031 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 215689007032 FMN binding site [chemical binding]; other site 215689007033 active site 215689007034 catalytic residues [active] 215689007035 substrate binding site [chemical binding]; other site 215689007036 L,D-transpeptidase; Provisional; Region: PRK10260 215689007037 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 215689007038 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 215689007039 potential frameshift: common BLAST hit: gi|292898947|ref|YP_003538316.1| glycosyl hydrolase 215689007040 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 215689007041 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 215689007042 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 215689007043 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 215689007044 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 215689007045 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 215689007046 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 215689007047 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 215689007048 Mechanosensitive ion channel; Region: MS_channel; pfam00924 215689007049 D-lactate dehydrogenase; Provisional; Region: PRK11183 215689007050 FAD binding domain; Region: FAD_binding_4; pfam01565 215689007051 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 215689007052 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 215689007053 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 215689007054 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 215689007055 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 215689007056 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 215689007057 active site 215689007058 metal binding site [ion binding]; metal-binding site 215689007059 nudix motif; other site 215689007060 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 215689007061 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 215689007062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689007063 S-adenosylmethionine binding site [chemical binding]; other site 215689007064 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 215689007065 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 215689007066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 215689007067 short chain dehydrogenase; Provisional; Region: PRK06101 215689007068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 215689007069 NAD(P) binding site [chemical binding]; other site 215689007070 active site 215689007071 SnoaL-like domain; Region: SnoaL_2; pfam12680 215689007072 transcriptional regulator MirA; Provisional; Region: PRK15043 215689007073 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 215689007074 DNA binding residues [nucleotide binding] 215689007075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689007076 sequence-specific DNA binding site [nucleotide binding]; other site 215689007077 salt bridge; other site 215689007078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 215689007079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689007080 Coenzyme A binding pocket [chemical binding]; other site 215689007081 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 215689007082 DEAD_2; Region: DEAD_2; pfam06733 215689007083 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 215689007084 glycosyl transferase family protein; Provisional; Region: PRK08136 215689007085 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 215689007086 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 215689007087 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 215689007088 metal binding site [ion binding]; metal-binding site 215689007089 putative dimer interface [polypeptide binding]; other site 215689007090 urocanate hydratase; Provisional; Region: PRK05414 215689007091 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 215689007092 active sites [active] 215689007093 tetramer interface [polypeptide binding]; other site 215689007094 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 215689007095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689007096 DNA-binding site [nucleotide binding]; DNA binding site 215689007097 UTRA domain; Region: UTRA; pfam07702 215689007098 HutD; Region: HutD; cl01532 215689007099 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 215689007100 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 215689007101 active site 215689007102 imidazolonepropionase; Validated; Region: PRK09356 215689007103 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 215689007104 active site 215689007105 N-formylglutamate amidohydrolase; Region: FGase; cl01522 215689007106 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 215689007107 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 215689007108 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 215689007109 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 215689007110 Mechanosensitive ion channel; Region: MS_channel; pfam00924 215689007111 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 215689007112 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 215689007113 Walker A/P-loop; other site 215689007114 ATP binding site [chemical binding]; other site 215689007115 Q-loop/lid; other site 215689007116 ABC transporter signature motif; other site 215689007117 Walker B; other site 215689007118 D-loop; other site 215689007119 H-loop/switch region; other site 215689007120 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 215689007121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007122 dimer interface [polypeptide binding]; other site 215689007123 conserved gate region; other site 215689007124 putative PBP binding loops; other site 215689007125 ABC-ATPase subunit interface; other site 215689007126 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 215689007127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689007128 substrate binding pocket [chemical binding]; other site 215689007129 membrane-bound complex binding site; other site 215689007130 hinge residues; other site 215689007131 hypothetical protein; Provisional; Region: PRK11019 215689007132 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 215689007133 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 215689007134 dimerization interface [polypeptide binding]; other site 215689007135 DPS ferroxidase diiron center [ion binding]; other site 215689007136 ion pore; other site 215689007137 threonine and homoserine efflux system; Provisional; Region: PRK10532 215689007138 EamA-like transporter family; Region: EamA; pfam00892 215689007139 outer membrane protein X; Provisional; Region: ompX; PRK09408 215689007140 manganese transport regulator MntR; Provisional; Region: PRK11050 215689007141 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 215689007142 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 215689007143 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 215689007144 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 215689007145 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689007146 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 215689007147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689007148 putative substrate translocation pore; other site 215689007149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689007150 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 215689007151 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 215689007152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689007153 putative substrate translocation pore; other site 215689007154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689007155 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 215689007156 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689007157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689007158 Walker A/P-loop; other site 215689007159 ATP binding site [chemical binding]; other site 215689007160 ABC transporter signature motif; other site 215689007161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689007162 Walker B; other site 215689007163 ABC transporter; Region: ABC_tran_2; pfam12848 215689007164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689007165 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 215689007166 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 215689007167 ATP binding site [chemical binding]; other site 215689007168 substrate interface [chemical binding]; other site 215689007169 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 215689007170 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 215689007171 dimer interface [polypeptide binding]; other site 215689007172 putative functional site; other site 215689007173 putative MPT binding site; other site 215689007174 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 215689007175 catalytic nucleophile [active] 215689007176 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 215689007177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689007178 Walker A/P-loop; other site 215689007179 ATP binding site [chemical binding]; other site 215689007180 Q-loop/lid; other site 215689007181 ABC transporter signature motif; other site 215689007182 Walker B; other site 215689007183 D-loop; other site 215689007184 H-loop/switch region; other site 215689007185 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 215689007186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689007187 Walker A/P-loop; other site 215689007188 ATP binding site [chemical binding]; other site 215689007189 Q-loop/lid; other site 215689007190 ABC transporter signature motif; other site 215689007191 Walker B; other site 215689007192 D-loop; other site 215689007193 H-loop/switch region; other site 215689007194 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 215689007195 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 215689007196 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 215689007197 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 215689007198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007199 dimer interface [polypeptide binding]; other site 215689007200 conserved gate region; other site 215689007201 putative PBP binding loops; other site 215689007202 ABC-ATPase subunit interface; other site 215689007203 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 215689007204 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 215689007205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007206 dimer interface [polypeptide binding]; other site 215689007207 conserved gate region; other site 215689007208 putative PBP binding loops; other site 215689007209 ABC-ATPase subunit interface; other site 215689007210 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 215689007211 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 215689007212 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 215689007213 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 215689007214 serine transporter; Region: stp; TIGR00814 215689007215 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 215689007216 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 215689007217 active site 215689007218 putative transporter; Provisional; Region: PRK04972 215689007219 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 215689007220 TrkA-C domain; Region: TrkA_C; pfam02080 215689007221 TrkA-C domain; Region: TrkA_C; pfam02080 215689007222 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 215689007223 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 215689007224 GSH binding site [chemical binding]; other site 215689007225 catalytic residues [active] 215689007226 hypothetical protein; Provisional; Region: PRK10591 215689007227 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 215689007228 dimer interface [polypeptide binding]; other site 215689007229 FMN binding site [chemical binding]; other site 215689007230 NADPH bind site [chemical binding]; other site 215689007231 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 215689007232 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 215689007233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 215689007234 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 215689007235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689007236 Walker A/P-loop; other site 215689007237 ATP binding site [chemical binding]; other site 215689007238 Q-loop/lid; other site 215689007239 ABC transporter signature motif; other site 215689007240 Walker B; other site 215689007241 D-loop; other site 215689007242 H-loop/switch region; other site 215689007243 TOBE domain; Region: TOBE_2; pfam08402 215689007244 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 215689007245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007246 dimer interface [polypeptide binding]; other site 215689007247 conserved gate region; other site 215689007248 putative PBP binding loops; other site 215689007249 ABC-ATPase subunit interface; other site 215689007250 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 215689007251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007252 dimer interface [polypeptide binding]; other site 215689007253 conserved gate region; other site 215689007254 putative PBP binding loops; other site 215689007255 ABC-ATPase subunit interface; other site 215689007256 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 215689007257 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 215689007258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689007259 substrate binding pocket [chemical binding]; other site 215689007260 membrane-bound complex binding site; other site 215689007261 hinge residues; other site 215689007262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007263 dimer interface [polypeptide binding]; other site 215689007264 conserved gate region; other site 215689007265 putative PBP binding loops; other site 215689007266 ABC-ATPase subunit interface; other site 215689007267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 215689007268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007269 dimer interface [polypeptide binding]; other site 215689007270 conserved gate region; other site 215689007271 putative PBP binding loops; other site 215689007272 ABC-ATPase subunit interface; other site 215689007273 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 215689007274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689007275 substrate binding pocket [chemical binding]; other site 215689007276 membrane-bound complex binding site; other site 215689007277 hinge residues; other site 215689007278 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 215689007279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689007280 Walker A/P-loop; other site 215689007281 ATP binding site [chemical binding]; other site 215689007282 Q-loop/lid; other site 215689007283 ABC transporter signature motif; other site 215689007284 Walker B; other site 215689007285 D-loop; other site 215689007286 H-loop/switch region; other site 215689007287 putative lipoprotein; Provisional; Region: PRK10533 215689007288 hypothetical protein; Provisional; Region: PRK02877 215689007289 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 215689007290 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 215689007291 amidase catalytic site [active] 215689007292 Zn binding residues [ion binding]; other site 215689007293 substrate binding site [chemical binding]; other site 215689007294 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 215689007295 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 215689007296 tetramer interface [polypeptide binding]; other site 215689007297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689007298 catalytic residue [active] 215689007299 pyruvate dehydrogenase; Provisional; Region: PRK09124 215689007300 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 215689007301 PYR/PP interface [polypeptide binding]; other site 215689007302 dimer interface [polypeptide binding]; other site 215689007303 tetramer interface [polypeptide binding]; other site 215689007304 TPP binding site [chemical binding]; other site 215689007305 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 215689007306 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 215689007307 TPP-binding site [chemical binding]; other site 215689007308 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 215689007309 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 215689007310 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 215689007311 putative active site [active] 215689007312 putative metal-binding site [ion binding]; other site 215689007313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 215689007314 DNA-binding site [nucleotide binding]; DNA binding site 215689007315 RNA-binding motif; other site 215689007316 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 215689007317 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 215689007318 Clp amino terminal domain; Region: Clp_N; pfam02861 215689007319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689007320 Walker A motif; other site 215689007321 ATP binding site [chemical binding]; other site 215689007322 Walker B motif; other site 215689007323 arginine finger; other site 215689007324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689007325 Walker A motif; other site 215689007326 ATP binding site [chemical binding]; other site 215689007327 Walker B motif; other site 215689007328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 215689007329 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 215689007330 rRNA binding site [nucleotide binding]; other site 215689007331 predicted 30S ribosome binding site; other site 215689007332 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 215689007333 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 215689007334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 215689007335 Walker A/P-loop; other site 215689007336 ATP binding site [chemical binding]; other site 215689007337 Q-loop/lid; other site 215689007338 ABC transporter signature motif; other site 215689007339 Walker B; other site 215689007340 D-loop; other site 215689007341 H-loop/switch region; other site 215689007342 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 215689007343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 215689007344 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 215689007345 Walker A/P-loop; other site 215689007346 ATP binding site [chemical binding]; other site 215689007347 Q-loop/lid; other site 215689007348 ABC transporter signature motif; other site 215689007349 Walker B; other site 215689007350 D-loop; other site 215689007351 H-loop/switch region; other site 215689007352 thioredoxin reductase; Provisional; Region: PRK10262 215689007353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 215689007354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 215689007355 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 215689007356 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 215689007357 putative DNA binding site [nucleotide binding]; other site 215689007358 putative Zn2+ binding site [ion binding]; other site 215689007359 AsnC family; Region: AsnC_trans_reg; pfam01037 215689007360 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 215689007361 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 215689007362 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 215689007363 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 215689007364 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 215689007365 recombination factor protein RarA; Reviewed; Region: PRK13342 215689007366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689007367 Walker A motif; other site 215689007368 ATP binding site [chemical binding]; other site 215689007369 Walker B motif; other site 215689007370 arginine finger; other site 215689007371 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 215689007372 seryl-tRNA synthetase; Provisional; Region: PRK05431 215689007373 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 215689007374 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 215689007375 dimer interface [polypeptide binding]; other site 215689007376 active site 215689007377 motif 1; other site 215689007378 motif 2; other site 215689007379 motif 3; other site 215689007380 putative MFS family transporter protein; Provisional; Region: PRK03633 215689007381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689007382 putative substrate translocation pore; other site 215689007383 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 215689007384 uncharacterized domain; Region: TIGR00702 215689007385 YcaO-like family; Region: YcaO; pfam02624 215689007386 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 215689007387 homodimer interface [polypeptide binding]; other site 215689007388 substrate-cofactor binding pocket; other site 215689007389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689007390 catalytic residue [active] 215689007391 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 215689007392 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 215689007393 hinge; other site 215689007394 active site 215689007395 cytidylate kinase; Provisional; Region: cmk; PRK00023 215689007396 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 215689007397 CMP-binding site; other site 215689007398 The sites determining sugar specificity; other site 215689007399 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 215689007400 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 215689007401 RNA binding site [nucleotide binding]; other site 215689007402 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 215689007403 RNA binding site [nucleotide binding]; other site 215689007404 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 215689007405 RNA binding site [nucleotide binding]; other site 215689007406 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 215689007407 RNA binding site [nucleotide binding]; other site 215689007408 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 215689007409 RNA binding site [nucleotide binding]; other site 215689007410 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 215689007411 IHF dimer interface [polypeptide binding]; other site 215689007412 IHF - DNA interface [nucleotide binding]; other site 215689007413 ComEC family competence protein; Provisional; Region: PRK11539 215689007414 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 215689007415 Competence protein; Region: Competence; pfam03772 215689007416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 215689007417 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 215689007418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 215689007419 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 215689007420 Walker A/P-loop; other site 215689007421 ATP binding site [chemical binding]; other site 215689007422 Q-loop/lid; other site 215689007423 ABC transporter signature motif; other site 215689007424 Walker B; other site 215689007425 D-loop; other site 215689007426 H-loop/switch region; other site 215689007427 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 215689007428 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 215689007429 Trm112p-like protein; Region: Trm112p; cl01066 215689007430 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 215689007431 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 215689007432 Ligand binding site; other site 215689007433 oligomer interface; other site 215689007434 Uncharacterized conserved protein [Function unknown]; Region: COG1434 215689007435 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 215689007436 putative active site [active] 215689007437 Methyltransferase domain; Region: Methyltransf_23; pfam13489 215689007438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689007439 S-adenosylmethionine binding site [chemical binding]; other site 215689007440 condesin subunit F; Provisional; Region: PRK05260 215689007441 condesin subunit E; Provisional; Region: PRK05256 215689007442 cell division protein MukB; Provisional; Region: mukB; PRK04863 215689007443 MukB N-terminal; Region: MukB; pfam04310 215689007444 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 215689007445 murein L,D-transpeptidase; Provisional; Region: PRK10594 215689007446 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 215689007447 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 215689007448 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 215689007449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 215689007450 Peptidase M15; Region: Peptidase_M15_3; cl01194 215689007451 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 215689007452 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 215689007453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689007454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689007455 homodimer interface [polypeptide binding]; other site 215689007456 catalytic residue [active] 215689007457 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 215689007458 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 215689007459 trimer interface [polypeptide binding]; other site 215689007460 eyelet of channel; other site 215689007461 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 215689007462 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 215689007463 putative dimer interface [polypeptide binding]; other site 215689007464 putative anticodon binding site; other site 215689007465 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 215689007466 homodimer interface [polypeptide binding]; other site 215689007467 motif 1; other site 215689007468 motif 2; other site 215689007469 active site 215689007470 motif 3; other site 215689007471 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 215689007472 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 215689007473 active site 215689007474 aminopeptidase N; Provisional; Region: pepN; PRK14015 215689007475 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 215689007476 active site 215689007477 Zn binding site [ion binding]; other site 215689007478 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 215689007479 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 215689007480 Walker A/P-loop; other site 215689007481 ATP binding site [chemical binding]; other site 215689007482 Q-loop/lid; other site 215689007483 ABC transporter signature motif; other site 215689007484 Walker B; other site 215689007485 D-loop; other site 215689007486 H-loop/switch region; other site 215689007487 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 215689007488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689007489 dimer interface [polypeptide binding]; other site 215689007490 conserved gate region; other site 215689007491 putative PBP binding loops; other site 215689007492 ABC-ATPase subunit interface; other site 215689007493 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 215689007494 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 215689007495 active site 215689007496 dimer interface [polypeptide binding]; other site 215689007497 non-prolyl cis peptide bond; other site 215689007498 insertion regions; other site 215689007499 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 215689007500 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689007501 substrate binding pocket [chemical binding]; other site 215689007502 membrane-bound complex binding site; other site 215689007503 hinge residues; other site 215689007504 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 215689007505 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 215689007506 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 215689007507 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 215689007508 quinone interaction residues [chemical binding]; other site 215689007509 active site 215689007510 catalytic residues [active] 215689007511 FMN binding site [chemical binding]; other site 215689007512 substrate binding site [chemical binding]; other site 215689007513 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 215689007514 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 215689007515 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 215689007516 MOSC domain; Region: MOSC; pfam03473 215689007517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 215689007518 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 215689007519 catalytic loop [active] 215689007520 iron binding site [ion binding]; other site 215689007521 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 215689007522 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 215689007523 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 215689007524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689007525 S-adenosylmethionine binding site [chemical binding]; other site 215689007526 ABC transporter ATPase component; Reviewed; Region: PRK11147 215689007527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689007528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689007529 ABC transporter; Region: ABC_tran_2; pfam12848 215689007530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 215689007531 Paraquat-inducible protein A; Region: PqiA; pfam04403 215689007532 Paraquat-inducible protein A; Region: PqiA; pfam04403 215689007533 paraquat-inducible protein B; Provisional; Region: PRK10807 215689007534 mce related protein; Region: MCE; pfam02470 215689007535 mce related protein; Region: MCE; pfam02470 215689007536 mce related protein; Region: MCE; pfam02470 215689007537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 215689007538 Protein of unknown function (DUF330); Region: DUF330; pfam03886 215689007539 Ribosome modulation factor; Region: RMF; pfam04957 215689007540 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 215689007541 active site 1 [active] 215689007542 dimer interface [polypeptide binding]; other site 215689007543 active site 2 [active] 215689007544 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 215689007545 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 215689007546 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 215689007547 outer membrane protein A; Reviewed; Region: PRK10808 215689007548 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 215689007549 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 215689007550 ligand binding site [chemical binding]; other site 215689007551 SOS cell division inhibitor; Provisional; Region: PRK10595 215689007552 TfoX N-terminal domain; Region: TfoX_N; pfam04993 215689007553 TfoX C-terminal domain; Region: TfoX_C; pfam04994 215689007554 TIGR01666 family membrane protein; Region: YCCS 215689007555 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 215689007556 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 215689007557 hypothetical protein; Provisional; Region: PRK11770 215689007558 Domain of unknown function (DUF307); Region: DUF307; pfam03733 215689007559 Domain of unknown function (DUF307); Region: DUF307; pfam03733 215689007560 DNA helicase IV; Provisional; Region: helD; PRK11054 215689007561 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 215689007562 Part of AAA domain; Region: AAA_19; pfam13245 215689007563 Family description; Region: UvrD_C_2; pfam13538 215689007564 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 215689007565 active site 215689007566 dimer interfaces [polypeptide binding]; other site 215689007567 catalytic residues [active] 215689007568 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 215689007569 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 215689007570 heat shock protein HspQ; Provisional; Region: PRK14129 215689007571 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 215689007572 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 215689007573 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 215689007574 putative RNA binding site [nucleotide binding]; other site 215689007575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689007576 S-adenosylmethionine binding site [chemical binding]; other site 215689007577 acylphosphatase; Provisional; Region: PRK14426 215689007578 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 215689007579 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 215689007580 YccA-like proteins; Region: YccA_like; cd10433 215689007581 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 215689007582 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 215689007583 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 215689007584 catalytic core [active] 215689007585 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 215689007586 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 215689007587 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 215689007588 NAD(P) binding site [chemical binding]; other site 215689007589 catalytic residues [active] 215689007590 hypothetical protein; Provisional; Region: PRK10174 215689007591 EamA-like transporter family; Region: EamA; pfam00892 215689007592 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 215689007593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689007594 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 215689007595 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 215689007596 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 215689007597 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 215689007598 Autoinducer binding domain; Region: Autoind_bind; pfam03472 215689007599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689007600 DNA binding residues [nucleotide binding] 215689007601 dimerization interface [polypeptide binding]; other site 215689007602 Autoinducer synthetase; Region: Autoind_synth; cl17404 215689007603 hypothetical protein; Provisional; Region: PRK10613 215689007604 response regulator; Provisional; Region: PRK09483 215689007605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689007606 active site 215689007607 phosphorylation site [posttranslational modification] 215689007608 intermolecular recognition site; other site 215689007609 dimerization interface [polypeptide binding]; other site 215689007610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689007611 DNA binding residues [nucleotide binding] 215689007612 dimerization interface [polypeptide binding]; other site 215689007613 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 215689007614 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 215689007615 GIY-YIG motif/motif A; other site 215689007616 active site 215689007617 catalytic site [active] 215689007618 putative DNA binding site [nucleotide binding]; other site 215689007619 metal binding site [ion binding]; metal-binding site 215689007620 UvrB/uvrC motif; Region: UVR; pfam02151 215689007621 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 215689007622 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 215689007623 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 215689007624 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 215689007625 Transposase; Region: HTH_Tnp_1; cl17663 215689007626 Transposase; Region: HTH_Tnp_1; cl17663 215689007627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 215689007628 MarR family; Region: MarR; pfam01047 215689007629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689007630 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 215689007631 putative substrate translocation pore; other site 215689007632 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 215689007633 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 215689007634 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689007635 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 215689007636 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 215689007637 PLD-like domain; Region: PLDc_2; pfam13091 215689007638 putative active site [active] 215689007639 catalytic site [active] 215689007640 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 215689007641 PLD-like domain; Region: PLDc_2; pfam13091 215689007642 putative active site [active] 215689007643 catalytic site [active] 215689007644 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 215689007645 Acyltransferase family; Region: Acyl_transf_3; pfam01757 215689007646 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 215689007647 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 215689007648 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 215689007649 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 215689007650 Ligand binding site; other site 215689007651 DXD motif; other site 215689007652 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 215689007653 secY/secA suppressor protein; Provisional; Region: PRK11467 215689007654 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 215689007655 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 215689007656 putative acyl-acceptor binding pocket; other site 215689007657 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 215689007658 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 215689007659 active site residue [active] 215689007660 hypothetical protein; Provisional; Region: PRK03757 215689007661 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 215689007662 potential frameshift: common BLAST hit: gi|378769578|ref|YP_005198055.1| proline/betaine transporter ProP 215689007663 proline/glycine betaine transporter; Provisional; Region: PRK10642 215689007664 proline/glycine betaine transporter; Provisional; Region: PRK10642 215689007665 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 215689007666 hydroxyglutarate oxidase; Provisional; Region: PRK11728 215689007667 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 215689007668 DNA damage-inducible protein I; Provisional; Region: PRK10597 215689007669 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 215689007670 active site 215689007671 substrate binding pocket [chemical binding]; other site 215689007672 dimer interface [polypeptide binding]; other site 215689007673 lipoprotein; Provisional; Region: PRK10598 215689007674 glutaredoxin 2; Provisional; Region: PRK10387 215689007675 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 215689007676 C-terminal domain interface [polypeptide binding]; other site 215689007677 GSH binding site (G-site) [chemical binding]; other site 215689007678 catalytic residues [active] 215689007679 putative dimer interface [polypeptide binding]; other site 215689007680 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 215689007681 N-terminal domain interface [polypeptide binding]; other site 215689007682 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 215689007683 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 215689007684 hypothetical protein; Provisional; Region: PRK11239 215689007685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 215689007686 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 215689007687 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 215689007688 FlgN protein; Region: FlgN; cl09176 215689007689 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 215689007690 SAF-like; Region: SAF_2; pfam13144 215689007691 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 215689007692 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 215689007693 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 215689007694 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 215689007695 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 215689007696 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689007697 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 215689007698 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 215689007699 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 215689007700 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 215689007701 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 215689007702 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 215689007703 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 215689007704 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689007705 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 215689007706 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 215689007707 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 215689007708 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 215689007709 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 215689007710 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689007711 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 215689007712 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 215689007713 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 215689007714 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 215689007715 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 215689007716 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 215689007717 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 215689007718 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 215689007719 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 215689007720 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 215689007721 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 215689007722 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 215689007723 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 215689007724 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 215689007725 homodimer interface [polypeptide binding]; other site 215689007726 oligonucleotide binding site [chemical binding]; other site 215689007727 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 215689007728 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689007729 RNA binding surface [nucleotide binding]; other site 215689007730 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 215689007731 active site 215689007732 Maf-like protein; Region: Maf; pfam02545 215689007733 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 215689007734 active site 215689007735 dimer interface [polypeptide binding]; other site 215689007736 hypothetical protein; Provisional; Region: PRK11193 215689007737 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 215689007738 putative phosphate acyltransferase; Provisional; Region: PRK05331 215689007739 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 215689007740 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 215689007741 dimer interface [polypeptide binding]; other site 215689007742 active site 215689007743 CoA binding pocket [chemical binding]; other site 215689007744 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 215689007745 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 215689007746 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 215689007747 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 215689007748 NAD(P) binding site [chemical binding]; other site 215689007749 homotetramer interface [polypeptide binding]; other site 215689007750 homodimer interface [polypeptide binding]; other site 215689007751 active site 215689007752 acyl carrier protein; Provisional; Region: acpP; PRK00982 215689007753 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 215689007754 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 215689007755 dimer interface [polypeptide binding]; other site 215689007756 active site 215689007757 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 215689007758 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 215689007759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689007760 catalytic residue [active] 215689007761 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 215689007762 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 215689007763 dimerization interface [polypeptide binding]; other site 215689007764 thymidylate kinase; Validated; Region: tmk; PRK00698 215689007765 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 215689007766 TMP-binding site; other site 215689007767 ATP-binding site [chemical binding]; other site 215689007768 DNA polymerase III subunit delta'; Validated; Region: PRK07993 215689007769 DNA polymerase III subunit delta'; Validated; Region: PRK08485 215689007770 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 215689007771 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 215689007772 active site 215689007773 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 215689007774 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 215689007775 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 215689007776 active site turn [active] 215689007777 phosphorylation site [posttranslational modification] 215689007778 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 215689007779 nucleotide binding site/active site [active] 215689007780 HIT family signature motif; other site 215689007781 catalytic residue [active] 215689007782 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 215689007783 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 215689007784 putative dimer interface [polypeptide binding]; other site 215689007785 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 215689007786 thiamine kinase; Region: ycfN_thiK; TIGR02721 215689007787 active site 215689007788 ATP binding site [chemical binding]; other site 215689007789 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 215689007790 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 215689007791 substrate binding site [chemical binding]; other site 215689007792 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 215689007793 beta-hexosaminidase; Provisional; Region: PRK05337 215689007794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 215689007795 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 215689007796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 215689007797 hypothetical protein; Provisional; Region: PRK11280 215689007798 transcription-repair coupling factor; Provisional; Region: PRK10689 215689007799 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 215689007800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689007801 ATP binding site [chemical binding]; other site 215689007802 putative Mg++ binding site [ion binding]; other site 215689007803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689007804 nucleotide binding region [chemical binding]; other site 215689007805 ATP-binding site [chemical binding]; other site 215689007806 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 215689007807 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 215689007808 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 215689007809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689007810 active site 215689007811 motif I; other site 215689007812 motif II; other site 215689007813 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 215689007814 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 215689007815 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 215689007816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689007817 DNA binding residues [nucleotide binding] 215689007818 dimerization interface [polypeptide binding]; other site 215689007819 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 215689007820 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 215689007821 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 215689007822 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 215689007823 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 215689007824 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 215689007825 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 215689007826 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 215689007827 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 215689007828 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 215689007829 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 215689007830 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 215689007831 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 215689007832 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 215689007833 Walker A motif/ATP binding site; other site 215689007834 Walker B motif; other site 215689007835 flagellar assembly protein H; Validated; Region: fliH; PRK05687 215689007836 Flagellar assembly protein FliH; Region: FliH; pfam02108 215689007837 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 215689007838 FliG C-terminal domain; Region: FliG_C; pfam01706 215689007839 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 215689007840 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 215689007841 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 215689007842 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 215689007843 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 215689007844 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 215689007845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689007846 active site 215689007847 phosphorylation site [posttranslational modification] 215689007848 intermolecular recognition site; other site 215689007849 dimerization interface [polypeptide binding]; other site 215689007850 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 215689007851 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 215689007852 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 215689007853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 215689007854 metal binding site [ion binding]; metal-binding site 215689007855 active site 215689007856 I-site; other site 215689007857 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 215689007858 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 215689007859 FtsX-like permease family; Region: FtsX; pfam02687 215689007860 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 215689007861 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 215689007862 Walker A/P-loop; other site 215689007863 ATP binding site [chemical binding]; other site 215689007864 Q-loop/lid; other site 215689007865 ABC transporter signature motif; other site 215689007866 Walker B; other site 215689007867 D-loop; other site 215689007868 H-loop/switch region; other site 215689007869 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 215689007870 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 215689007871 FtsX-like permease family; Region: FtsX; pfam02687 215689007872 fructokinase; Reviewed; Region: PRK09557 215689007873 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 215689007874 nucleotide binding site [chemical binding]; other site 215689007875 NAD-dependent deacetylase; Provisional; Region: PRK00481 215689007876 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 215689007877 NAD+ binding site [chemical binding]; other site 215689007878 substrate binding site [chemical binding]; other site 215689007879 Zn binding site [ion binding]; other site 215689007880 benzoate transporter; Region: benE; TIGR00843 215689007881 Benzoate membrane transport protein; Region: BenE; pfam03594 215689007882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689007883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689007884 non-specific DNA binding site [nucleotide binding]; other site 215689007885 salt bridge; other site 215689007886 sequence-specific DNA binding site [nucleotide binding]; other site 215689007887 Cupin domain; Region: Cupin_2; pfam07883 215689007888 Uncharacterized conserved protein [Function unknown]; Region: COG2850 215689007889 Cupin-like domain; Region: Cupin_8; pfam13621 215689007890 sensor protein PhoQ; Provisional; Region: PRK10815 215689007891 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 215689007892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689007893 dimer interface [polypeptide binding]; other site 215689007894 phosphorylation site [posttranslational modification] 215689007895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689007896 ATP binding site [chemical binding]; other site 215689007897 Mg2+ binding site [ion binding]; other site 215689007898 G-X-G motif; other site 215689007899 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 215689007900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689007901 active site 215689007902 phosphorylation site [posttranslational modification] 215689007903 intermolecular recognition site; other site 215689007904 dimerization interface [polypeptide binding]; other site 215689007905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689007906 DNA binding site [nucleotide binding] 215689007907 adenylosuccinate lyase; Provisional; Region: PRK09285 215689007908 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 215689007909 tetramer interface [polypeptide binding]; other site 215689007910 active site 215689007911 putative lysogenization regulator; Reviewed; Region: PRK00218 215689007912 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 215689007913 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 215689007914 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 215689007915 nudix motif; other site 215689007916 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 215689007917 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 215689007918 active site 215689007919 isocitrate dehydrogenase; Validated; Region: PRK07362 215689007920 isocitrate dehydrogenase; Reviewed; Region: PRK07006 215689007921 P63C domain; Region: P63C; pfam10546 215689007922 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 215689007923 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 215689007924 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689007925 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 215689007926 dimer interface [polypeptide binding]; other site 215689007927 active site 215689007928 Int/Topo IB signature motif; other site 215689007929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689007930 Transposase; Region: HTH_Tnp_1; pfam01527 215689007931 HTH-like domain; Region: HTH_21; pfam13276 215689007932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689007933 Integrase core domain; Region: rve; pfam00665 215689007934 Integrase core domain; Region: rve_3; pfam13683 215689007935 Methyltransferase domain; Region: Methyltransf_27; pfam13708 215689007936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689007937 S-adenosylmethionine binding site [chemical binding]; other site 215689007938 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 215689007939 exonuclease VIII; Reviewed; Region: PRK09709 215689007940 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 215689007941 transcriptional repressor DicA; Reviewed; Region: PRK09706 215689007942 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 215689007943 HNH endonuclease; Region: HNH_3; pfam13392 215689007944 small toxic polypeptide; Provisional; Region: PRK09738 215689007945 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 215689007946 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 215689007947 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 215689007948 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 215689007949 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 215689007950 Predicted chitinase [General function prediction only]; Region: COG3179 215689007951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689007952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689007953 non-specific DNA binding site [nucleotide binding]; other site 215689007954 salt bridge; other site 215689007955 sequence-specific DNA binding site [nucleotide binding]; other site 215689007956 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 215689007957 ParB-like nuclease domain; Region: ParBc; pfam02195 215689007958 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 215689007959 Terminase small subunit; Region: Terminase_2; cl01513 215689007960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 215689007961 Terminase-like family; Region: Terminase_6; pfam03237 215689007962 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 215689007963 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 215689007964 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 215689007965 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 215689007966 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 215689007967 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 215689007968 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 215689007969 hypothetical protein; Region: PHA02310 215689007970 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 215689007971 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 215689007972 Baseplate J-like protein; Region: Baseplate_J; cl01294 215689007973 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 215689007974 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 215689007975 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 215689007976 Mig-14; Region: Mig-14; pfam07395 215689007977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 215689007978 Protein of unknown function (DUF754); Region: DUF754; pfam05449 215689007979 DinI-like family; Region: DinI; cl11630 215689007980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 215689007981 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 215689007982 dimer interface [polypeptide binding]; other site 215689007983 catalytic triad [active] 215689007984 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 215689007985 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 215689007986 N-acetyl-D-glucosamine binding site [chemical binding]; other site 215689007987 catalytic residue [active] 215689007988 hypothetical protein; Provisional; Region: PRK10457 215689007989 Trehalase; Region: Trehalase; cl17346 215689007990 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 215689007991 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 215689007992 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 215689007993 fumarate hydratase; Provisional; Region: PRK15389 215689007994 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 215689007995 Fumarase C-terminus; Region: Fumerase_C; pfam05683 215689007996 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 215689007997 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 215689007998 transmembrane helices; other site 215689007999 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 215689008000 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 215689008001 putative active site [active] 215689008002 putative FMN binding site [chemical binding]; other site 215689008003 putative substrate binding site [chemical binding]; other site 215689008004 putative catalytic residue [active] 215689008005 FMN-binding domain; Region: FMN_bind; cl01081 215689008006 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 215689008007 L-aspartate oxidase; Provisional; Region: PRK06175 215689008008 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 215689008009 ApbE family; Region: ApbE; pfam02424 215689008010 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 215689008011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689008012 active site 215689008013 phosphorylation site [posttranslational modification] 215689008014 intermolecular recognition site; other site 215689008015 dimerization interface [polypeptide binding]; other site 215689008016 sensory histidine kinase DcuS; Provisional; Region: PRK11086 215689008017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689008018 ATP binding site [chemical binding]; other site 215689008019 Mg2+ binding site [ion binding]; other site 215689008020 G-X-G motif; other site 215689008021 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 215689008022 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 215689008023 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 215689008024 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 215689008025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 215689008026 DNA binding site [nucleotide binding] 215689008027 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 215689008028 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 215689008029 Type III secretion needle MxiH like; Region: MxiH; cl09641 215689008030 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 215689008031 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 215689008032 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 215689008033 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 215689008034 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689008035 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 215689008036 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 215689008037 HrpJ-like domain; Region: HrpJ; pfam07201 215689008038 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 215689008039 type III secretion system protein InvA; Provisional; Region: PRK15337 215689008040 ATP synthase SpaL; Validated; Region: PRK08149 215689008041 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 215689008042 Walker A motif; other site 215689008043 ATP binding site [chemical binding]; other site 215689008044 Walker B motif; other site 215689008045 type III secretion system protein SpaO; Validated; Region: PRK08158 215689008046 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 215689008047 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 215689008048 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 215689008049 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 215689008050 type III secretion system protein SpaS; Validated; Region: PRK08156 215689008051 chaperone protein SicA; Provisional; Region: PRK15331 215689008052 Tetratricopeptide repeat; Region: TPR_3; pfam07720 215689008053 Tetratricopeptide repeat; Region: TPR_3; pfam07720 215689008054 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 215689008055 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 215689008056 GTP-binding protein YchF; Reviewed; Region: PRK09601 215689008057 YchF GTPase; Region: YchF; cd01900 215689008058 G1 box; other site 215689008059 GTP/Mg2+ binding site [chemical binding]; other site 215689008060 Switch I region; other site 215689008061 G2 box; other site 215689008062 Switch II region; other site 215689008063 G3 box; other site 215689008064 G4 box; other site 215689008065 G5 box; other site 215689008066 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 215689008067 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 215689008068 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 215689008069 Sulfate transporter family; Region: Sulfate_transp; pfam00916 215689008070 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 215689008071 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 215689008072 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 215689008073 putative active site [active] 215689008074 catalytic residue [active] 215689008075 hypothetical protein; Provisional; Region: PRK10692 215689008076 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 215689008077 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 215689008078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689008079 active site 215689008080 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 215689008081 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 215689008082 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 215689008083 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 215689008084 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 215689008085 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 215689008086 tRNA; other site 215689008087 putative tRNA binding site [nucleotide binding]; other site 215689008088 putative NADP binding site [chemical binding]; other site 215689008089 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 215689008090 peptide chain release factor 1; Validated; Region: prfA; PRK00591 215689008091 This domain is found in peptide chain release factors; Region: PCRF; smart00937 215689008092 RF-1 domain; Region: RF-1; pfam00472 215689008093 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 215689008094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689008095 S-adenosylmethionine binding site [chemical binding]; other site 215689008096 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 215689008097 hypothetical protein; Provisional; Region: PRK10941 215689008098 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 215689008099 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 215689008100 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 215689008101 META domain; Region: META; cl01245 215689008102 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 215689008103 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 215689008104 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 215689008105 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689008106 DNA binding site [nucleotide binding] 215689008107 domain linker motif; other site 215689008108 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 215689008109 dimerization interface [polypeptide binding]; other site 215689008110 ligand binding site [chemical binding]; other site 215689008111 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 215689008112 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 215689008113 substrate binding [chemical binding]; other site 215689008114 active site 215689008115 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 215689008116 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 215689008117 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 215689008118 active site turn [active] 215689008119 phosphorylation site [posttranslational modification] 215689008120 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 215689008121 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 215689008122 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 215689008123 trimer interface; other site 215689008124 sugar binding site [chemical binding]; other site 215689008125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 215689008126 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 215689008127 putative ATP binding site [chemical binding]; other site 215689008128 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 215689008129 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 215689008130 putative active site pocket [active] 215689008131 dimerization interface [polypeptide binding]; other site 215689008132 putative catalytic residue [active] 215689008133 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 215689008134 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 215689008135 phosphopeptide binding site; other site 215689008136 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 215689008137 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 215689008138 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 215689008139 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 215689008140 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 215689008141 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 215689008142 ligand binding site [chemical binding]; other site 215689008143 putative invasin; Provisional; Region: PRK10177 215689008144 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 215689008145 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 215689008146 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 215689008147 trimer interface [polypeptide binding]; other site 215689008148 eyelet of channel; other site 215689008149 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 215689008150 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 215689008151 inhibitor-cofactor binding pocket; inhibition site 215689008152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689008153 catalytic residue [active] 215689008154 arginine succinyltransferase; Provisional; Region: PRK10456 215689008155 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 215689008156 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 215689008157 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 215689008158 NAD(P) binding site [chemical binding]; other site 215689008159 catalytic residues [active] 215689008160 succinylarginine dihydrolase; Provisional; Region: PRK13281 215689008161 succinylglutamate desuccinylase; Provisional; Region: PRK05324 215689008162 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 215689008163 active site 215689008164 Zn binding site [ion binding]; other site 215689008165 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 215689008166 dimer interface [polypeptide binding]; other site 215689008167 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 215689008168 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 215689008169 GIY-YIG motif/motif A; other site 215689008170 active site 215689008171 catalytic site [active] 215689008172 putative DNA binding site [nucleotide binding]; other site 215689008173 metal binding site [ion binding]; metal-binding site 215689008174 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 215689008175 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 215689008176 homodimer interface [polypeptide binding]; other site 215689008177 NAD binding pocket [chemical binding]; other site 215689008178 ATP binding pocket [chemical binding]; other site 215689008179 Mg binding site [ion binding]; other site 215689008180 active-site loop [active] 215689008181 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 215689008182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008183 putative substrate translocation pore; other site 215689008184 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 215689008185 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 215689008186 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 215689008187 inner membrane protein; Provisional; Region: PRK11648 215689008188 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 215689008189 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 215689008190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689008191 motif II; other site 215689008192 YniB-like protein; Region: YniB; pfam14002 215689008193 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 215689008194 Phosphotransferase enzyme family; Region: APH; pfam01636 215689008195 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 215689008196 Protein of unknown function, DUF481; Region: DUF481; cl01213 215689008197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 215689008198 Transposase; Region: DEDD_Tnp_IS110; pfam01548 215689008199 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 215689008200 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 215689008201 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 215689008202 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 215689008203 active site 215689008204 dimer interface [polypeptide binding]; other site 215689008205 motif 1; other site 215689008206 motif 2; other site 215689008207 motif 3; other site 215689008208 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 215689008209 anticodon binding site; other site 215689008210 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 215689008211 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 215689008212 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 215689008213 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 215689008214 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 215689008215 23S rRNA binding site [nucleotide binding]; other site 215689008216 L21 binding site [polypeptide binding]; other site 215689008217 L13 binding site [polypeptide binding]; other site 215689008218 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 215689008219 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 215689008220 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 215689008221 dimer interface [polypeptide binding]; other site 215689008222 motif 1; other site 215689008223 active site 215689008224 motif 2; other site 215689008225 motif 3; other site 215689008226 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 215689008227 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 215689008228 putative tRNA-binding site [nucleotide binding]; other site 215689008229 B3/4 domain; Region: B3_4; pfam03483 215689008230 tRNA synthetase B5 domain; Region: B5; smart00874 215689008231 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 215689008232 dimer interface [polypeptide binding]; other site 215689008233 motif 1; other site 215689008234 motif 3; other site 215689008235 motif 2; other site 215689008236 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 215689008237 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 215689008238 IHF dimer interface [polypeptide binding]; other site 215689008239 IHF - DNA interface [nucleotide binding]; other site 215689008240 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 215689008241 catalytic residues [active] 215689008242 dimer interface [polypeptide binding]; other site 215689008243 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 215689008244 NlpC/P60 family; Region: NLPC_P60; pfam00877 215689008245 Uncharacterized conserved protein [Function unknown]; Region: COG0397 215689008246 hypothetical protein; Validated; Region: PRK00029 215689008247 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 215689008248 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 215689008249 Walker A/P-loop; other site 215689008250 ATP binding site [chemical binding]; other site 215689008251 Q-loop/lid; other site 215689008252 ABC transporter signature motif; other site 215689008253 Walker B; other site 215689008254 D-loop; other site 215689008255 H-loop/switch region; other site 215689008256 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 215689008257 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 215689008258 ABC-ATPase subunit interface; other site 215689008259 dimer interface [polypeptide binding]; other site 215689008260 putative PBP binding regions; other site 215689008261 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 215689008262 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 215689008263 intersubunit interface [polypeptide binding]; other site 215689008264 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 215689008265 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 215689008266 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 215689008267 PEP synthetase regulatory protein; Provisional; Region: PRK05339 215689008268 phosphoenolpyruvate synthase; Validated; Region: PRK06464 215689008269 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 215689008270 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 215689008271 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 215689008272 putative inner membrane protein; Provisional; Region: PRK10983 215689008273 Domain of unknown function DUF20; Region: UPF0118; pfam01594 215689008274 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 215689008275 FAD binding domain; Region: FAD_binding_4; pfam01565 215689008276 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 215689008277 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 215689008278 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 215689008279 putative ABC transporter; Region: ycf24; CHL00085 215689008280 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 215689008281 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 215689008282 Walker A/P-loop; other site 215689008283 ATP binding site [chemical binding]; other site 215689008284 Q-loop/lid; other site 215689008285 ABC transporter signature motif; other site 215689008286 Walker B; other site 215689008287 D-loop; other site 215689008288 H-loop/switch region; other site 215689008289 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 215689008290 FeS assembly protein SufD; Region: sufD; TIGR01981 215689008291 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 215689008292 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 215689008293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689008294 catalytic residue [active] 215689008295 cysteine desufuration protein SufE; Provisional; Region: PRK09296 215689008296 murein lipoprotein; Provisional; Region: PRK15396 215689008297 pyruvate kinase; Provisional; Region: PRK09206 215689008298 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 215689008299 active site 215689008300 domain interfaces; other site 215689008301 multidrug efflux protein; Reviewed; Region: PRK01766 215689008302 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 215689008303 cation binding site [ion binding]; other site 215689008304 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 215689008305 Lumazine binding domain; Region: Lum_binding; pfam00677 215689008306 Lumazine binding domain; Region: Lum_binding; pfam00677 215689008307 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 215689008308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689008309 S-adenosylmethionine binding site [chemical binding]; other site 215689008310 putative transporter; Provisional; Region: PRK11043 215689008311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008312 putative substrate translocation pore; other site 215689008313 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 215689008314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689008315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 215689008316 dimerization interface [polypeptide binding]; other site 215689008317 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 215689008318 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689008319 DNA binding site [nucleotide binding] 215689008320 domain linker motif; other site 215689008321 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 215689008322 dimerization interface [polypeptide binding]; other site 215689008323 ligand binding site [chemical binding]; other site 215689008324 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 215689008325 NlpC/P60 family; Region: NLPC_P60; pfam00877 215689008326 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 215689008327 putative GSH binding site [chemical binding]; other site 215689008328 catalytic residues [active] 215689008329 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 215689008330 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 215689008331 dimer interface [polypeptide binding]; other site 215689008332 catalytic site [active] 215689008333 putative active site [active] 215689008334 putative substrate binding site [chemical binding]; other site 215689008335 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 215689008336 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 215689008337 dimer interface [polypeptide binding]; other site 215689008338 active site 215689008339 metal binding site [ion binding]; metal-binding site 215689008340 glutathione binding site [chemical binding]; other site 215689008341 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 215689008342 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 215689008343 FMN binding site [chemical binding]; other site 215689008344 active site 215689008345 substrate binding site [chemical binding]; other site 215689008346 catalytic residue [active] 215689008347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 215689008348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689008349 putative metal dependent hydrolase; Provisional; Region: PRK11598 215689008350 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 215689008351 Sulfatase; Region: Sulfatase; pfam00884 215689008352 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 215689008353 Transposase, Mutator family; Region: Transposase_mut; pfam00872 215689008354 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 215689008355 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 215689008356 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 215689008357 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 215689008358 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 215689008359 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 215689008360 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 215689008361 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 215689008362 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 215689008363 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 215689008364 active site 215689008365 HIGH motif; other site 215689008366 dimer interface [polypeptide binding]; other site 215689008367 KMSKS motif; other site 215689008368 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689008369 RNA binding surface [nucleotide binding]; other site 215689008370 pyridoxamine kinase; Validated; Region: PRK05756 215689008371 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 215689008372 dimer interface [polypeptide binding]; other site 215689008373 pyridoxal binding site [chemical binding]; other site 215689008374 ATP binding site [chemical binding]; other site 215689008375 glutathionine S-transferase; Provisional; Region: PRK10542 215689008376 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 215689008377 C-terminal domain interface [polypeptide binding]; other site 215689008378 GSH binding site (G-site) [chemical binding]; other site 215689008379 dimer interface [polypeptide binding]; other site 215689008380 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 215689008381 dimer interface [polypeptide binding]; other site 215689008382 N-terminal domain interface [polypeptide binding]; other site 215689008383 substrate binding pocket (H-site) [chemical binding]; other site 215689008384 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 215689008385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008386 putative substrate translocation pore; other site 215689008387 POT family; Region: PTR2; pfam00854 215689008388 transcriptional regulator BetI; Validated; Region: PRK00767 215689008389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689008390 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 215689008391 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 215689008392 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 215689008393 tetrameric interface [polypeptide binding]; other site 215689008394 NAD binding site [chemical binding]; other site 215689008395 catalytic residues [active] 215689008396 choline dehydrogenase; Validated; Region: PRK02106 215689008397 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 215689008398 endonuclease III; Provisional; Region: PRK10702 215689008399 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 215689008400 minor groove reading motif; other site 215689008401 helix-hairpin-helix signature motif; other site 215689008402 substrate binding pocket [chemical binding]; other site 215689008403 active site 215689008404 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 215689008405 electron transport complex RsxE subunit; Provisional; Region: PRK12405 215689008406 electron transport complex protein RnfG; Validated; Region: PRK01908 215689008407 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 215689008408 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 215689008409 SLBB domain; Region: SLBB; pfam10531 215689008410 electron transport complex protein RnfB; Provisional; Region: PRK05113 215689008411 Putative Fe-S cluster; Region: FeS; cl17515 215689008412 4Fe-4S binding domain; Region: Fer4; pfam00037 215689008413 electron transport complex protein RsxA; Provisional; Region: PRK05151 215689008414 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 215689008415 L-arabinose isomerase; Provisional; Region: PRK02929 215689008416 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 215689008417 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 215689008418 trimer interface [polypeptide binding]; other site 215689008419 putative substrate binding site [chemical binding]; other site 215689008420 putative metal binding site [ion binding]; other site 215689008421 ribulokinase; Provisional; Region: PRK04123 215689008422 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 215689008423 N- and C-terminal domain interface [polypeptide binding]; other site 215689008424 active site 215689008425 MgATP binding site [chemical binding]; other site 215689008426 catalytic site [active] 215689008427 metal binding site [ion binding]; metal-binding site 215689008428 carbohydrate binding site [chemical binding]; other site 215689008429 homodimer interface [polypeptide binding]; other site 215689008430 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 215689008431 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 215689008432 ligand binding site [chemical binding]; other site 215689008433 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 215689008434 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 215689008435 Walker A/P-loop; other site 215689008436 ATP binding site [chemical binding]; other site 215689008437 Q-loop/lid; other site 215689008438 ABC transporter signature motif; other site 215689008439 Walker B; other site 215689008440 D-loop; other site 215689008441 H-loop/switch region; other site 215689008442 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 215689008443 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 215689008444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 215689008445 TM-ABC transporter signature motif; other site 215689008446 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 215689008447 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 215689008448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689008449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689008450 putative oxidoreductase; Provisional; Region: PRK11579 215689008451 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 215689008452 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 215689008453 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 215689008454 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 215689008455 active site 215689008456 purine riboside binding site [chemical binding]; other site 215689008457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 215689008458 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 215689008459 fumarate hydratase; Reviewed; Region: fumC; PRK00485 215689008460 Class II fumarases; Region: Fumarase_classII; cd01362 215689008461 active site 215689008462 tetramer interface [polypeptide binding]; other site 215689008463 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 215689008464 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 215689008465 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 215689008466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008467 putative substrate translocation pore; other site 215689008468 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 215689008469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689008470 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 215689008471 dimerization interface [polypeptide binding]; other site 215689008472 substrate binding pocket [chemical binding]; other site 215689008473 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 215689008474 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 215689008475 nucleotide binding site [chemical binding]; other site 215689008476 potential frameshift: common BLAST hit: gi|259908496|ref|YP_002648852.1| dethiobiotin synthetase 2 215689008477 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 215689008478 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 215689008479 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 215689008480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008481 putative substrate translocation pore; other site 215689008482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008483 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 215689008484 hypothetical protein; Provisional; Region: PRK13659 215689008485 malonic semialdehyde reductase; Provisional; Region: PRK10538 215689008486 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 215689008487 putative NAD(P) binding site [chemical binding]; other site 215689008488 homodimer interface [polypeptide binding]; other site 215689008489 homotetramer interface [polypeptide binding]; other site 215689008490 active site 215689008491 guanine deaminase; Provisional; Region: PRK09228 215689008492 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 215689008493 active site 215689008494 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 215689008495 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 215689008496 active site 215689008497 Zn binding site [ion binding]; other site 215689008498 hypothetical protein; Provisional; Region: PRK06847 215689008499 hypothetical protein; Provisional; Region: PRK07236 215689008500 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 215689008501 Protein of unknown function (DUF441); Region: DUF441; cl01041 215689008502 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 215689008503 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 215689008504 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 215689008505 NAD(P) binding site [chemical binding]; other site 215689008506 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 215689008507 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 215689008508 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 215689008509 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 215689008510 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 215689008511 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 215689008512 active site 215689008513 non-prolyl cis peptide bond; other site 215689008514 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 215689008515 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 215689008516 N-terminal plug; other site 215689008517 ligand-binding site [chemical binding]; other site 215689008518 Rdx family; Region: Rdx; cl01407 215689008519 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 215689008520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 215689008521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689008522 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 215689008523 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 215689008524 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 215689008525 active site 215689008526 catalytic site [active] 215689008527 putative metal binding site [ion binding]; other site 215689008528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 215689008529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689008530 Coenzyme A binding pocket [chemical binding]; other site 215689008531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 215689008532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 215689008533 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 215689008534 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 215689008535 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 215689008536 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 215689008537 tetramer interface [polypeptide binding]; other site 215689008538 heme binding pocket [chemical binding]; other site 215689008539 NADPH binding site [chemical binding]; other site 215689008540 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 215689008541 Fic/DOC family; Region: Fic; cl00960 215689008542 Nitrate and nitrite sensing; Region: NIT; pfam08376 215689008543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689008544 dimerization interface [polypeptide binding]; other site 215689008545 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 215689008546 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689008547 dimer interface [polypeptide binding]; other site 215689008548 putative CheW interface [polypeptide binding]; other site 215689008549 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 215689008550 active site clefts [active] 215689008551 zinc binding site [ion binding]; other site 215689008552 dimer interface [polypeptide binding]; other site 215689008553 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 215689008554 malate:quinone oxidoreductase; Validated; Region: PRK05257 215689008555 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 215689008556 Virulence factor SrfB; Region: SrfB; pfam07520 215689008557 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 215689008558 hypothetical protein; Provisional; Region: PRK08244 215689008559 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 215689008560 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 215689008561 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 215689008562 substrate binding pocket [chemical binding]; other site 215689008563 active site 215689008564 iron coordination sites [ion binding]; other site 215689008565 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 215689008566 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 215689008567 RNAase interaction site [polypeptide binding]; other site 215689008568 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 215689008569 active site 215689008570 Domain of unknown function DUF20; Region: UPF0118; pfam01594 215689008571 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 215689008572 Rrf2 family protein; Region: rrf2_super; TIGR00738 215689008573 Transcriptional regulator; Region: Rrf2; pfam02082 215689008574 Transcriptional regulator; Region: Rrf2; cl17282 215689008575 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 215689008576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 215689008577 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 215689008578 glutaminase; Provisional; Region: PRK00971 215689008579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008580 putative arabinose transporter; Provisional; Region: PRK03545 215689008581 putative substrate translocation pore; other site 215689008582 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 215689008583 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 215689008584 peptide binding site [polypeptide binding]; other site 215689008585 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 215689008586 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 215689008587 metal binding site [ion binding]; metal-binding site 215689008588 dimer interface [polypeptide binding]; other site 215689008589 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 215689008590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689008591 dimerization interface [polypeptide binding]; other site 215689008592 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689008593 dimer interface [polypeptide binding]; other site 215689008594 putative CheW interface [polypeptide binding]; other site 215689008595 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 215689008596 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 215689008597 substrate binding pocket [chemical binding]; other site 215689008598 catalytic triad [active] 215689008599 benzoate transport; Region: 2A0115; TIGR00895 215689008600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008601 putative substrate translocation pore; other site 215689008602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689008603 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 215689008604 Acyltransferase family; Region: Acyl_transf_3; pfam01757 215689008605 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 215689008606 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 215689008607 substrate binding [chemical binding]; other site 215689008608 active site 215689008609 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 215689008610 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 215689008611 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 215689008612 ligand binding site [chemical binding]; other site 215689008613 flexible hinge region; other site 215689008614 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 215689008615 putative switch regulator; other site 215689008616 non-specific DNA interactions [nucleotide binding]; other site 215689008617 DNA binding site [nucleotide binding] 215689008618 sequence specific DNA binding site [nucleotide binding]; other site 215689008619 putative cAMP binding site [chemical binding]; other site 215689008620 universal stress protein UspE; Provisional; Region: PRK11175 215689008621 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 215689008622 Ligand Binding Site [chemical binding]; other site 215689008623 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 215689008624 Ligand Binding Site [chemical binding]; other site 215689008625 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 215689008626 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 215689008627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 215689008628 N-terminal plug; other site 215689008629 ligand-binding site [chemical binding]; other site 215689008630 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 215689008631 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 215689008632 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 215689008633 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 215689008634 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 215689008635 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 215689008636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689008637 active site 215689008638 phosphorylation site [posttranslational modification] 215689008639 intermolecular recognition site; other site 215689008640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689008641 DNA binding site [nucleotide binding] 215689008642 sensor protein RstB; Provisional; Region: PRK10604 215689008643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689008644 dimerization interface [polypeptide binding]; other site 215689008645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689008646 dimer interface [polypeptide binding]; other site 215689008647 phosphorylation site [posttranslational modification] 215689008648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689008649 ATP binding site [chemical binding]; other site 215689008650 Mg2+ binding site [ion binding]; other site 215689008651 G-X-G motif; other site 215689008652 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 215689008653 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 215689008654 active site 215689008655 Zn binding site [ion binding]; other site 215689008656 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 215689008657 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 215689008658 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 215689008659 amidase catalytic site [active] 215689008660 Zn binding residues [ion binding]; other site 215689008661 substrate binding site [chemical binding]; other site 215689008662 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 215689008663 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 215689008664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689008665 ATP binding site [chemical binding]; other site 215689008666 putative Mg++ binding site [ion binding]; other site 215689008667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689008668 nucleotide binding region [chemical binding]; other site 215689008669 ATP-binding site [chemical binding]; other site 215689008670 Helicase associated domain (HA2); Region: HA2; pfam04408 215689008671 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 215689008672 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 215689008673 azoreductase; Reviewed; Region: PRK00170 215689008674 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 215689008675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 215689008676 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 215689008677 hypothetical protein; Provisional; Region: PRK10695 215689008678 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 215689008679 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 215689008680 putative ligand binding site [chemical binding]; other site 215689008681 putative NAD binding site [chemical binding]; other site 215689008682 catalytic site [active] 215689008683 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 215689008684 Domain of unknown function (DUF333); Region: DUF333; pfam03891 215689008685 Uncharacterized conserved protein [Function unknown]; Region: COG1359 215689008686 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 215689008687 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 215689008688 ATP binding site [chemical binding]; other site 215689008689 Mg++ binding site [ion binding]; other site 215689008690 motif III; other site 215689008691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689008692 nucleotide binding region [chemical binding]; other site 215689008693 ATP-binding site [chemical binding]; other site 215689008694 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 215689008695 putative RNA binding site [nucleotide binding]; other site 215689008696 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 215689008697 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 215689008698 Ligand Binding Site [chemical binding]; other site 215689008699 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 215689008700 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 215689008701 Ca binding site [ion binding]; other site 215689008702 active site 215689008703 catalytic site [active] 215689008704 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 215689008705 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 215689008706 Cl binding site [ion binding]; other site 215689008707 oligomer interface [polypeptide binding]; other site 215689008708 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 215689008709 putative fimbrial chaperone protein; Provisional; Region: PRK09918 215689008710 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 215689008711 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 215689008712 PapC N-terminal domain; Region: PapC_N; pfam13954 215689008713 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 215689008714 PapC C-terminal domain; Region: PapC_C; pfam13953 215689008715 hypothetical protein; Provisional; Region: PRK15301 215689008716 AAA domain; Region: AAA_33; pfam13671 215689008717 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 215689008718 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 215689008719 peptide binding site [polypeptide binding]; other site 215689008720 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 215689008721 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 215689008722 active site 215689008723 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 215689008724 dimer interface [polypeptide binding]; other site 215689008725 catalytic triad [active] 215689008726 peroxidatic and resolving cysteines [active] 215689008727 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 215689008728 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 215689008729 putative aromatic amino acid binding site; other site 215689008730 PAS domain; Region: PAS; smart00091 215689008731 putative active site [active] 215689008732 heme pocket [chemical binding]; other site 215689008733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689008734 Walker A motif; other site 215689008735 ATP binding site [chemical binding]; other site 215689008736 Walker B motif; other site 215689008737 arginine finger; other site 215689008738 hypothetical protein; Provisional; Region: PRK05415 215689008739 Domain of unknown function (DUF697); Region: DUF697; cl12064 215689008740 Predicted ATPase [General function prediction only]; Region: COG3106 215689008741 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 215689008742 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 215689008743 phage shock protein C; Region: phageshock_pspC; TIGR02978 215689008744 phage shock protein B; Provisional; Region: pspB; PRK09458 215689008745 phage shock protein PspA; Provisional; Region: PRK10698 215689008746 Predicted coiled-coil domain-containing protein; Region: TTKRSYEDQ; pfam10212 215689008747 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 215689008748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689008749 Walker A motif; other site 215689008750 ATP binding site [chemical binding]; other site 215689008751 Walker B motif; other site 215689008752 arginine finger; other site 215689008753 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 215689008754 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 215689008755 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 215689008756 peptide binding site [polypeptide binding]; other site 215689008757 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 215689008758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689008759 dimer interface [polypeptide binding]; other site 215689008760 conserved gate region; other site 215689008761 putative PBP binding loops; other site 215689008762 ABC-ATPase subunit interface; other site 215689008763 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 215689008764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689008765 dimer interface [polypeptide binding]; other site 215689008766 conserved gate region; other site 215689008767 putative PBP binding loops; other site 215689008768 ABC-ATPase subunit interface; other site 215689008769 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 215689008770 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689008771 Walker A/P-loop; other site 215689008772 ATP binding site [chemical binding]; other site 215689008773 Q-loop/lid; other site 215689008774 ABC transporter signature motif; other site 215689008775 Walker B; other site 215689008776 D-loop; other site 215689008777 H-loop/switch region; other site 215689008778 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 215689008779 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 215689008780 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689008781 Walker A/P-loop; other site 215689008782 ATP binding site [chemical binding]; other site 215689008783 Q-loop/lid; other site 215689008784 ABC transporter signature motif; other site 215689008785 Walker B; other site 215689008786 D-loop; other site 215689008787 H-loop/switch region; other site 215689008788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 215689008789 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 215689008790 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 215689008791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689008792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689008793 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 215689008794 dimerization interface [polypeptide binding]; other site 215689008795 PAAR motif; Region: PAAR_motif; pfam05488 215689008796 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 215689008797 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 215689008798 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 215689008799 putative molybdopterin cofactor binding site [chemical binding]; other site 215689008800 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 215689008801 putative molybdopterin cofactor binding site; other site 215689008802 exoribonuclease II; Provisional; Region: PRK05054 215689008803 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 215689008804 RNB domain; Region: RNB; pfam00773 215689008805 S1 RNA binding domain; Region: S1; pfam00575 215689008806 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 215689008807 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 215689008808 intersubunit interface [polypeptide binding]; other site 215689008809 active site 215689008810 Zn2+ binding site [ion binding]; other site 215689008811 lipoprotein; Provisional; Region: PRK10540 215689008812 translation initiation factor Sui1; Validated; Region: PRK06824 215689008813 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 215689008814 putative rRNA binding site [nucleotide binding]; other site 215689008815 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 215689008816 active site 215689008817 dimer interface [polypeptide binding]; other site 215689008818 tetratricopeptide repeat protein; Provisional; Region: PRK11788 215689008819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 215689008820 TPR motif; other site 215689008821 binding surface 215689008822 Predicted membrane protein [Function unknown]; Region: COG3771 215689008823 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 215689008824 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 215689008825 active site 215689008826 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 215689008827 dimerization interface [polypeptide binding]; other site 215689008828 active site 215689008829 aconitate hydratase; Validated; Region: PRK09277 215689008830 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 215689008831 substrate binding site [chemical binding]; other site 215689008832 ligand binding site [chemical binding]; other site 215689008833 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 215689008834 substrate binding site [chemical binding]; other site 215689008835 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 215689008836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689008837 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 215689008838 substrate binding site [chemical binding]; other site 215689008839 putative dimerization interface [polypeptide binding]; other site 215689008840 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 215689008841 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 215689008842 active site 215689008843 interdomain interaction site; other site 215689008844 putative metal-binding site [ion binding]; other site 215689008845 nucleotide binding site [chemical binding]; other site 215689008846 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 215689008847 domain I; other site 215689008848 DNA binding groove [nucleotide binding] 215689008849 phosphate binding site [ion binding]; other site 215689008850 domain II; other site 215689008851 domain III; other site 215689008852 nucleotide binding site [chemical binding]; other site 215689008853 catalytic site [active] 215689008854 domain IV; other site 215689008855 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 215689008856 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 215689008857 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 215689008858 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 215689008859 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 215689008860 putative inner membrane peptidase; Provisional; Region: PRK11778 215689008861 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 215689008862 tandem repeat interface [polypeptide binding]; other site 215689008863 oligomer interface [polypeptide binding]; other site 215689008864 active site residues [active] 215689008865 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 215689008866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 215689008867 NAD(P) binding site [chemical binding]; other site 215689008868 active site 215689008869 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 215689008870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689008871 RNA binding surface [nucleotide binding]; other site 215689008872 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 215689008873 probable active site [active] 215689008874 hypothetical protein; Provisional; Region: PRK11630 215689008875 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 215689008876 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 215689008877 active site 215689008878 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 215689008879 anthranilate synthase component I; Provisional; Region: PRK13564 215689008880 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 215689008881 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 215689008882 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 215689008883 Glutamine amidotransferase class-I; Region: GATase; pfam00117 215689008884 glutamine binding [chemical binding]; other site 215689008885 catalytic triad [active] 215689008886 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 215689008887 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 215689008888 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 215689008889 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 215689008890 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 215689008891 active site 215689008892 ribulose/triose binding site [chemical binding]; other site 215689008893 phosphate binding site [ion binding]; other site 215689008894 substrate (anthranilate) binding pocket [chemical binding]; other site 215689008895 product (indole) binding pocket [chemical binding]; other site 215689008896 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 215689008897 active site 215689008898 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 215689008899 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 215689008900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689008901 catalytic residue [active] 215689008902 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 215689008903 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 215689008904 substrate binding site [chemical binding]; other site 215689008905 active site 215689008906 catalytic residues [active] 215689008907 heterodimer interface [polypeptide binding]; other site 215689008908 BON domain; Region: BON; pfam04972 215689008909 outer membrane protein W; Provisional; Region: PRK10959 215689008910 hypothetical protein; Provisional; Region: PRK02868 215689008911 intracellular septation protein A; Reviewed; Region: PRK00259 215689008912 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 215689008913 transport protein TonB; Provisional; Region: PRK10819 215689008914 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 215689008915 YciI-like protein; Reviewed; Region: PRK11370 215689008916 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 215689008917 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 215689008918 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 215689008919 putative active site [active] 215689008920 catalytic site [active] 215689008921 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 215689008922 putative active site [active] 215689008923 catalytic site [active] 215689008924 dsDNA-mimic protein; Reviewed; Region: PRK05094 215689008925 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 215689008926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689008927 Walker A/P-loop; other site 215689008928 ATP binding site [chemical binding]; other site 215689008929 Q-loop/lid; other site 215689008930 ABC transporter signature motif; other site 215689008931 Walker B; other site 215689008932 D-loop; other site 215689008933 H-loop/switch region; other site 215689008934 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 215689008935 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 215689008936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689008937 Walker A/P-loop; other site 215689008938 ATP binding site [chemical binding]; other site 215689008939 Q-loop/lid; other site 215689008940 ABC transporter signature motif; other site 215689008941 Walker B; other site 215689008942 D-loop; other site 215689008943 H-loop/switch region; other site 215689008944 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 215689008945 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 215689008946 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 215689008947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689008948 dimer interface [polypeptide binding]; other site 215689008949 conserved gate region; other site 215689008950 ABC-ATPase subunit interface; other site 215689008951 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 215689008952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689008953 dimer interface [polypeptide binding]; other site 215689008954 conserved gate region; other site 215689008955 putative PBP binding loops; other site 215689008956 ABC-ATPase subunit interface; other site 215689008957 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 215689008958 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 215689008959 peptide binding site [polypeptide binding]; other site 215689008960 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 215689008961 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 215689008962 peptide binding site [polypeptide binding]; other site 215689008963 hypothetical protein; Provisional; Region: PRK11111 215689008964 thymidine kinase; Provisional; Region: PRK04296 215689008965 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 215689008966 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 215689008967 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 215689008968 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 215689008969 putative NAD(P) binding site [chemical binding]; other site 215689008970 active site 215689008971 putative substrate binding site [chemical binding]; other site 215689008972 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 215689008973 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 215689008974 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 215689008975 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 215689008976 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 215689008977 active site 215689008978 tetramer interface; other site 215689008979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689008980 active site 215689008981 response regulator of RpoS; Provisional; Region: PRK10693 215689008982 phosphorylation site [posttranslational modification] 215689008983 intermolecular recognition site; other site 215689008984 dimerization interface [polypeptide binding]; other site 215689008985 SEC-C motif; Region: SEC-C; pfam02810 215689008986 hypothetical protein; Provisional; Region: PRK04233 215689008987 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 215689008988 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 215689008989 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 215689008990 putative active site [active] 215689008991 putative substrate binding site [chemical binding]; other site 215689008992 putative cosubstrate binding site; other site 215689008993 catalytic site [active] 215689008994 HTH-like domain; Region: HTH_21; pfam13276 215689008995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689008996 Integrase core domain; Region: rve; pfam00665 215689008997 Integrase core domain; Region: rve_3; pfam13683 215689008998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689008999 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 215689009000 putative catalytic site [active] 215689009001 putative phosphate binding site [ion binding]; other site 215689009002 active site 215689009003 metal binding site A [ion binding]; metal-binding site 215689009004 DNA binding site [nucleotide binding] 215689009005 putative AP binding site [nucleotide binding]; other site 215689009006 putative metal binding site B [ion binding]; other site 215689009007 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 215689009008 DNA topoisomerase III; Provisional; Region: PRK07726 215689009009 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 215689009010 active site 215689009011 putative interdomain interaction site [polypeptide binding]; other site 215689009012 putative metal-binding site [ion binding]; other site 215689009013 putative nucleotide binding site [chemical binding]; other site 215689009014 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 215689009015 domain I; other site 215689009016 DNA binding groove [nucleotide binding] 215689009017 phosphate binding site [ion binding]; other site 215689009018 domain II; other site 215689009019 domain III; other site 215689009020 nucleotide binding site [chemical binding]; other site 215689009021 catalytic site [active] 215689009022 domain IV; other site 215689009023 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 215689009024 putative FMN binding site [chemical binding]; other site 215689009025 protease 4; Provisional; Region: PRK10949 215689009026 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 215689009027 tandem repeat interface [polypeptide binding]; other site 215689009028 oligomer interface [polypeptide binding]; other site 215689009029 active site residues [active] 215689009030 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 215689009031 tandem repeat interface [polypeptide binding]; other site 215689009032 oligomer interface [polypeptide binding]; other site 215689009033 active site residues [active] 215689009034 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 215689009035 active site 215689009036 homodimer interface [polypeptide binding]; other site 215689009037 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 215689009038 Isochorismatase family; Region: Isochorismatase; pfam00857 215689009039 catalytic triad [active] 215689009040 metal binding site [ion binding]; metal-binding site 215689009041 conserved cis-peptide bond; other site 215689009042 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 215689009043 methionine sulfoxide reductase B; Provisional; Region: PRK00222 215689009044 SelR domain; Region: SelR; pfam01641 215689009045 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 215689009046 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 215689009047 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 215689009048 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 215689009049 active site 215689009050 phosphate binding residues; other site 215689009051 catalytic residues [active] 215689009052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 215689009053 catalytic tetrad [active] 215689009054 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 215689009055 PrkA family serine protein kinase; Provisional; Region: PRK15455 215689009056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689009057 Walker A motif; other site 215689009058 ATP binding site [chemical binding]; other site 215689009059 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 215689009060 hypothetical protein; Provisional; Region: PRK05325 215689009061 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 215689009062 TrkA-C domain; Region: TrkA_C; pfam02080 215689009063 Transporter associated domain; Region: CorC_HlyC; smart01091 215689009064 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 215689009065 Bacterial sugar transferase; Region: Bac_transf; pfam02397 215689009066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689009067 putative substrate translocation pore; other site 215689009068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 215689009069 alanine racemase; Reviewed; Region: dadX; PRK03646 215689009070 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 215689009071 active site 215689009072 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 215689009073 substrate binding site [chemical binding]; other site 215689009074 catalytic residues [active] 215689009075 dimer interface [polypeptide binding]; other site 215689009076 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 215689009077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 215689009078 hydroxyglutarate oxidase; Provisional; Region: PRK11728 215689009079 SpoVR family protein; Provisional; Region: PRK11767 215689009080 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 215689009081 fatty acid metabolism regulator; Provisional; Region: PRK04984 215689009082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689009083 DNA-binding site [nucleotide binding]; DNA binding site 215689009084 FadR C-terminal domain; Region: FadR_C; pfam07840 215689009085 disulfide bond formation protein B; Provisional; Region: PRK01749 215689009086 hypothetical protein; Provisional; Region: PRK05170 215689009087 hypothetical protein; Provisional; Region: PRK10691 215689009088 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 215689009089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 215689009090 septum formation inhibitor; Reviewed; Region: minC; PRK03511 215689009091 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 215689009092 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 215689009093 cell division inhibitor MinD; Provisional; Region: PRK10818 215689009094 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 215689009095 Switch I; other site 215689009096 Switch II; other site 215689009097 Septum formation topological specificity factor MinE; Region: MinE; cl00538 215689009098 ribonuclease D; Provisional; Region: PRK10829 215689009099 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 215689009100 catalytic site [active] 215689009101 putative active site [active] 215689009102 putative substrate binding site [chemical binding]; other site 215689009103 HRDC domain; Region: HRDC; pfam00570 215689009104 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 215689009105 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 215689009106 acyl-activating enzyme (AAE) consensus motif; other site 215689009107 putative AMP binding site [chemical binding]; other site 215689009108 putative active site [active] 215689009109 putative CoA binding site [chemical binding]; other site 215689009110 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 215689009111 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 215689009112 Glycoprotease family; Region: Peptidase_M22; pfam00814 215689009113 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 215689009114 DEAD/DEAH box helicase; Region: DEAD; pfam00270 215689009115 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 215689009116 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 215689009117 homotrimer interaction site [polypeptide binding]; other site 215689009118 putative active site [active] 215689009119 hypothetical protein; Provisional; Region: PRK05114 215689009120 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 215689009121 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 215689009122 chorismate binding enzyme; Region: Chorismate_bind; cl10555 215689009123 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 215689009124 putative active site [active] 215689009125 putative CoA binding site [chemical binding]; other site 215689009126 nudix motif; other site 215689009127 metal binding site [ion binding]; metal-binding site 215689009128 L-serine deaminase; Provisional; Region: PRK15023 215689009129 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 215689009130 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 215689009131 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 215689009132 FOG: CBS domain [General function prediction only]; Region: COG0517 215689009133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 215689009134 Transporter associated domain; Region: CorC_HlyC; smart01091 215689009135 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 215689009136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689009137 S-adenosylmethionine binding site [chemical binding]; other site 215689009138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 215689009139 DNA-binding site [nucleotide binding]; DNA binding site 215689009140 RNA-binding motif; other site 215689009141 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 215689009142 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 215689009143 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 215689009144 YebO-like protein; Region: YebO; pfam13974 215689009145 YobH-like protein; Region: YobH; pfam13996 215689009146 heat shock protein HtpX; Provisional; Region: PRK05457 215689009147 carboxy-terminal protease; Provisional; Region: PRK11186 215689009148 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 215689009149 protein binding site [polypeptide binding]; other site 215689009150 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 215689009151 Catalytic dyad [active] 215689009152 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 215689009153 ProP expression regulator; Provisional; Region: PRK04950 215689009154 ProQ/FINO family; Region: ProQ; pfam04352 215689009155 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 215689009156 GAF domain; Region: GAF_2; pfam13185 215689009157 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 215689009158 Paraquat-inducible protein A; Region: PqiA; pfam04403 215689009159 Paraquat-inducible protein A; Region: PqiA; pfam04403 215689009160 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 215689009161 mce related protein; Region: MCE; pfam02470 215689009162 mce related protein; Region: MCE; pfam02470 215689009163 mce related protein; Region: MCE; pfam02470 215689009164 mce related protein; Region: MCE; pfam02470 215689009165 mce related protein; Region: MCE; pfam02470 215689009166 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 215689009167 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 215689009168 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 215689009169 potential frameshift: common BLAST hit: gi|259908242|ref|YP_002648598.1| spermidine synthase 215689009170 Domain of unknown function DUF20; Region: UPF0118; pfam01594 215689009171 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 215689009172 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 215689009173 Biofilm formation and stress response factor; Region: BsmA; pfam10014 215689009174 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 215689009175 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 215689009176 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 215689009177 exodeoxyribonuclease X; Provisional; Region: PRK07983 215689009178 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 215689009179 active site 215689009180 catalytic site [active] 215689009181 substrate binding site [chemical binding]; other site 215689009182 protease 2; Provisional; Region: PRK10115 215689009183 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 215689009184 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 215689009185 YebG protein; Region: YebG; pfam07130 215689009186 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 215689009187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 215689009188 ATP-grasp domain; Region: ATP-grasp; pfam02222 215689009189 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 215689009190 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 215689009191 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 215689009192 pyruvate kinase; Provisional; Region: PRK05826 215689009193 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 215689009194 domain interfaces; other site 215689009195 active site 215689009196 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 215689009197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689009198 putative substrate translocation pore; other site 215689009199 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 215689009200 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 215689009201 putative acyl-acceptor binding pocket; other site 215689009202 putative peptidase; Provisional; Region: PRK11649 215689009203 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 215689009204 Peptidase family M23; Region: Peptidase_M23; pfam01551 215689009205 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 215689009206 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 215689009207 metal binding site [ion binding]; metal-binding site 215689009208 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 215689009209 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 215689009210 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 215689009211 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 215689009212 ABC-ATPase subunit interface; other site 215689009213 dimer interface [polypeptide binding]; other site 215689009214 putative PBP binding regions; other site 215689009215 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 215689009216 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 215689009217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689009218 Walker A motif; other site 215689009219 ATP binding site [chemical binding]; other site 215689009220 Walker B motif; other site 215689009221 arginine finger; other site 215689009222 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 215689009223 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 215689009224 RuvA N terminal domain; Region: RuvA_N; pfam01330 215689009225 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 215689009226 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 215689009227 active site 215689009228 putative DNA-binding cleft [nucleotide binding]; other site 215689009229 dimer interface [polypeptide binding]; other site 215689009230 hypothetical protein; Validated; Region: PRK00110 215689009231 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 215689009232 nudix motif; other site 215689009233 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 215689009234 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 215689009235 dimer interface [polypeptide binding]; other site 215689009236 anticodon binding site; other site 215689009237 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 215689009238 homodimer interface [polypeptide binding]; other site 215689009239 motif 1; other site 215689009240 active site 215689009241 motif 2; other site 215689009242 GAD domain; Region: GAD; pfam02938 215689009243 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 215689009244 active site 215689009245 motif 3; other site 215689009246 hypothetical protein; Provisional; Region: PRK10302 215689009247 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 215689009248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689009249 S-adenosylmethionine binding site [chemical binding]; other site 215689009250 Methyltransferase domain; Region: Methyltransf_31; pfam13847 215689009251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689009252 S-adenosylmethionine binding site [chemical binding]; other site 215689009253 copper homeostasis protein CutC; Provisional; Region: PRK11572 215689009254 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 215689009255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689009256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689009257 homodimer interface [polypeptide binding]; other site 215689009258 catalytic residue [active] 215689009259 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 215689009260 putative metal binding site [ion binding]; other site 215689009261 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 215689009262 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 215689009263 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 215689009264 active site 215689009265 HIGH motif; other site 215689009266 KMSK motif region; other site 215689009267 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 215689009268 tRNA binding surface [nucleotide binding]; other site 215689009269 anticodon binding site; other site 215689009270 Flagellar protein FlhE; Region: FlhE; pfam06366 215689009271 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 215689009272 FHIPEP family; Region: FHIPEP; pfam00771 215689009273 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 215689009274 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 215689009275 chemotaxis regulator CheZ; Provisional; Region: PRK11166 215689009276 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 215689009277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689009278 active site 215689009279 phosphorylation site [posttranslational modification] 215689009280 intermolecular recognition site; other site 215689009281 dimerization interface [polypeptide binding]; other site 215689009282 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 215689009283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689009284 active site 215689009285 phosphorylation site [posttranslational modification] 215689009286 intermolecular recognition site; other site 215689009287 dimerization interface [polypeptide binding]; other site 215689009288 CheB methylesterase; Region: CheB_methylest; pfam01339 215689009289 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 215689009290 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 215689009291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689009292 methyl-accepting protein IV; Provisional; Region: PRK09793 215689009293 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 215689009294 dimer interface [polypeptide binding]; other site 215689009295 ligand binding site [chemical binding]; other site 215689009296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689009297 dimerization interface [polypeptide binding]; other site 215689009298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689009299 dimer interface [polypeptide binding]; other site 215689009300 putative CheW interface [polypeptide binding]; other site 215689009301 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 215689009302 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 215689009303 dimer interface [polypeptide binding]; other site 215689009304 ligand binding site [chemical binding]; other site 215689009305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689009306 dimerization interface [polypeptide binding]; other site 215689009307 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689009308 dimer interface [polypeptide binding]; other site 215689009309 putative CheW interface [polypeptide binding]; other site 215689009310 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 215689009311 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 215689009312 dimer interface [polypeptide binding]; other site 215689009313 ligand binding site [chemical binding]; other site 215689009314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689009315 dimerization interface [polypeptide binding]; other site 215689009316 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689009317 dimer interface [polypeptide binding]; other site 215689009318 putative CheW interface [polypeptide binding]; other site 215689009319 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 215689009320 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 215689009321 dimer interface [polypeptide binding]; other site 215689009322 ligand binding site [chemical binding]; other site 215689009323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689009324 dimerization interface [polypeptide binding]; other site 215689009325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689009326 dimer interface [polypeptide binding]; other site 215689009327 putative CheW interface [polypeptide binding]; other site 215689009328 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 215689009329 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 215689009330 dimer interface [polypeptide binding]; other site 215689009331 ligand binding site [chemical binding]; other site 215689009332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689009333 dimerization interface [polypeptide binding]; other site 215689009334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 215689009335 dimer interface [polypeptide binding]; other site 215689009336 putative CheW interface [polypeptide binding]; other site 215689009337 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 215689009338 putative CheA interaction surface; other site 215689009339 chemotaxis protein CheA; Provisional; Region: PRK10547 215689009340 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 215689009341 putative binding surface; other site 215689009342 active site 215689009343 CheY binding; Region: CheY-binding; pfam09078 215689009344 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 215689009345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689009346 ATP binding site [chemical binding]; other site 215689009347 Mg2+ binding site [ion binding]; other site 215689009348 G-X-G motif; other site 215689009349 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 215689009350 flagellar motor protein MotB; Validated; Region: motB; PRK09041 215689009351 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 215689009352 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 215689009353 ligand binding site [chemical binding]; other site 215689009354 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 215689009355 flagellar motor protein MotA; Validated; Region: PRK09110 215689009356 transcriptional activator FlhC; Provisional; Region: PRK12722 215689009357 transcriptional activator FlhD; Provisional; Region: PRK02909 215689009358 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 215689009359 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 215689009360 active site 215689009361 homotetramer interface [polypeptide binding]; other site 215689009362 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 215689009363 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 215689009364 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 215689009365 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 215689009366 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 215689009367 Catalytic site [active] 215689009368 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 215689009369 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 215689009370 active site 215689009371 DNA binding site [nucleotide binding] 215689009372 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 215689009373 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 215689009374 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 215689009375 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 215689009376 dimer interface [polypeptide binding]; other site 215689009377 active site 215689009378 Schiff base residues; other site 215689009379 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 215689009380 Predicted flavoprotein [General function prediction only]; Region: COG0431 215689009381 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 215689009382 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 215689009383 potential frameshift: common BLAST hit: gi|292899754|ref|YP_003539123.1| oligosaccharide translocase 215689009384 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 215689009385 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 215689009386 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 215689009387 Na binding site [ion binding]; other site 215689009388 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 215689009389 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 215689009390 NAD(P) binding site [chemical binding]; other site 215689009391 catalytic residues [active] 215689009392 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 215689009393 EamA-like transporter family; Region: EamA; pfam00892 215689009394 EamA-like transporter family; Region: EamA; pfam00892 215689009395 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 215689009396 CcdB protein; Region: CcdB; cl03380 215689009397 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 215689009398 alkaline phosphatase; Provisional; Region: PRK10518 215689009399 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 215689009400 dimer interface [polypeptide binding]; other site 215689009401 active site 215689009402 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 215689009403 dimer interface [polypeptide binding]; other site 215689009404 FMN binding site [chemical binding]; other site 215689009405 NADPH bind site [chemical binding]; other site 215689009406 hypothetical protein; Provisional; Region: PRK10536 215689009407 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 215689009408 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 215689009409 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 215689009410 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 215689009411 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 215689009412 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 215689009413 Imelysin; Region: Peptidase_M75; pfam09375 215689009414 FTR1 family protein; Region: TIGR00145 215689009415 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 215689009416 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 215689009417 Na binding site [ion binding]; other site 215689009418 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 215689009419 Predicted transcriptional regulator [Transcription]; Region: COG3905 215689009420 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 215689009421 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 215689009422 Glutamate binding site [chemical binding]; other site 215689009423 NAD binding site [chemical binding]; other site 215689009424 catalytic residues [active] 215689009425 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 215689009426 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 215689009427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 215689009428 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 215689009429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 215689009430 DNA binding residues [nucleotide binding] 215689009431 HNH endonuclease; Region: HNH_2; pfam13391 215689009432 flagellin; Provisional; Region: PRK12802 215689009433 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 215689009434 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 215689009435 flagellar capping protein; Reviewed; Region: fliD; PRK08032 215689009436 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 215689009437 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 215689009438 flagellar protein FliS; Validated; Region: fliS; PRK05685 215689009439 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 215689009440 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 215689009441 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 215689009442 active site 215689009443 Na/Ca binding site [ion binding]; other site 215689009444 catalytic site [active] 215689009445 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 215689009446 lipoprotein; Provisional; Region: PRK10397 215689009447 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 215689009448 hypothetical protein; Provisional; Region: PRK10062 215689009449 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 215689009450 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 215689009451 additional DNA contacts [nucleotide binding]; other site 215689009452 mismatch recognition site; other site 215689009453 active site 215689009454 zinc binding site [ion binding]; other site 215689009455 DNA intercalation site [nucleotide binding]; other site 215689009456 DNA cytosine methylase; Provisional; Region: PRK10458 215689009457 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 215689009458 cofactor binding site; other site 215689009459 DNA binding site [nucleotide binding] 215689009460 substrate interaction site [chemical binding]; other site 215689009461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 215689009462 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 215689009463 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 215689009464 Zn2+ binding site [ion binding]; other site 215689009465 Mg2+ binding site [ion binding]; other site 215689009466 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 215689009467 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 215689009468 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689009469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689009470 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 215689009471 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 215689009472 heme binding site [chemical binding]; other site 215689009473 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 215689009474 heme binding site [chemical binding]; other site 215689009475 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 215689009476 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 215689009477 metal binding site [ion binding]; metal-binding site 215689009478 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 215689009479 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 215689009480 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 215689009481 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 215689009482 ABC-ATPase subunit interface; other site 215689009483 dimer interface [polypeptide binding]; other site 215689009484 putative PBP binding regions; other site 215689009485 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 215689009486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 215689009487 ABC-ATPase subunit interface; other site 215689009488 dimer interface [polypeptide binding]; other site 215689009489 putative PBP binding regions; other site 215689009490 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 215689009491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689009492 Walker A/P-loop; other site 215689009493 ATP binding site [chemical binding]; other site 215689009494 Q-loop/lid; other site 215689009495 ABC transporter signature motif; other site 215689009496 Walker B; other site 215689009497 D-loop; other site 215689009498 H-loop/switch region; other site 215689009499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 215689009500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689009501 Walker A/P-loop; other site 215689009502 ATP binding site [chemical binding]; other site 215689009503 Q-loop/lid; other site 215689009504 ABC transporter signature motif; other site 215689009505 Walker B; other site 215689009506 D-loop; other site 215689009507 H-loop/switch region; other site 215689009508 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 215689009509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689009510 dimer interface [polypeptide binding]; other site 215689009511 conserved gate region; other site 215689009512 putative PBP binding loops; other site 215689009513 ABC-ATPase subunit interface; other site 215689009514 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 215689009515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 215689009516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689009517 dimer interface [polypeptide binding]; other site 215689009518 conserved gate region; other site 215689009519 putative PBP binding loops; other site 215689009520 ABC-ATPase subunit interface; other site 215689009521 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 215689009522 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 215689009523 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 215689009524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 215689009525 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 215689009526 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 215689009527 substrate binding site; other site 215689009528 Manganese binding site; other site 215689009529 dimer interface; other site 215689009530 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 215689009531 potential frameshift: common BLAST hit: gi|300717400|ref|YP_003742203.1| AsnC family transcriptional regulator 215689009532 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 215689009533 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 215689009534 putative ligand binding site [chemical binding]; other site 215689009535 NAD binding site [chemical binding]; other site 215689009536 dimerization interface [polypeptide binding]; other site 215689009537 catalytic site [active] 215689009538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689009539 Coenzyme A binding pocket [chemical binding]; other site 215689009540 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 215689009541 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 215689009542 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 215689009543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689009544 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 215689009545 substrate binding site [chemical binding]; other site 215689009546 dimerization interface [polypeptide binding]; other site 215689009547 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 215689009548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689009549 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 215689009550 putative dimerization interface [polypeptide binding]; other site 215689009551 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 215689009552 TM-ABC transporter signature motif; other site 215689009553 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 215689009554 Predicted membrane protein [Function unknown]; Region: COG2323 215689009555 AMP nucleosidase; Provisional; Region: PRK08292 215689009556 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 215689009557 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 215689009558 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 215689009559 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 215689009560 putative NAD(P) binding site [chemical binding]; other site 215689009561 catalytic Zn binding site [ion binding]; other site 215689009562 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 215689009563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 215689009564 Walker A motif; other site 215689009565 ATP binding site [chemical binding]; other site 215689009566 Walker B motif; other site 215689009567 arginine finger; other site 215689009568 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 215689009569 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 215689009570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 215689009571 putative DNA binding site [nucleotide binding]; other site 215689009572 dimerization interface [polypeptide binding]; other site 215689009573 putative Zn2+ binding site [ion binding]; other site 215689009574 AsnC family; Region: AsnC_trans_reg; pfam01037 215689009575 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 215689009576 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 215689009577 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 215689009578 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 215689009579 acyl-activating enzyme (AAE) consensus motif; other site 215689009580 AMP binding site [chemical binding]; other site 215689009581 active site 215689009582 CoA binding site [chemical binding]; other site 215689009583 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 215689009584 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 215689009585 homodimer interface [polypeptide binding]; other site 215689009586 substrate-cofactor binding pocket; other site 215689009587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689009588 catalytic residue [active] 215689009589 Prephenate dehydratase; Region: PDT; pfam00800 215689009590 Uncharacterized conserved protein [Function unknown]; Region: COG2128 215689009591 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 215689009592 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 215689009593 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 215689009594 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 215689009595 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 215689009596 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 215689009597 active site 215689009598 FMN binding site [chemical binding]; other site 215689009599 substrate binding site [chemical binding]; other site 215689009600 homotetramer interface [polypeptide binding]; other site 215689009601 catalytic residue [active] 215689009602 MATE family multidrug exporter; Provisional; Region: PRK10189 215689009603 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 215689009604 hypothetical protein; Provisional; Region: PRK05423 215689009605 Predicted membrane protein [Function unknown]; Region: COG1289 215689009606 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 215689009607 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 215689009608 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 215689009609 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689009610 exonuclease I; Provisional; Region: sbcB; PRK11779 215689009611 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 215689009612 active site 215689009613 catalytic site [active] 215689009614 substrate binding site [chemical binding]; other site 215689009615 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 215689009616 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 215689009617 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 215689009618 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 215689009619 putative NAD(P) binding site [chemical binding]; other site 215689009620 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 215689009621 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 215689009622 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 215689009623 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 215689009624 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 215689009625 NAD binding site [chemical binding]; other site 215689009626 dimerization interface [polypeptide binding]; other site 215689009627 product binding site; other site 215689009628 substrate binding site [chemical binding]; other site 215689009629 zinc binding site [ion binding]; other site 215689009630 catalytic residues [active] 215689009631 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 215689009632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689009633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689009634 homodimer interface [polypeptide binding]; other site 215689009635 catalytic residue [active] 215689009636 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 215689009637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689009638 active site 215689009639 motif I; other site 215689009640 motif II; other site 215689009641 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 215689009642 putative active site pocket [active] 215689009643 4-fold oligomerization interface [polypeptide binding]; other site 215689009644 metal binding residues [ion binding]; metal-binding site 215689009645 3-fold/trimer interface [polypeptide binding]; other site 215689009646 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 215689009647 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 215689009648 putative active site [active] 215689009649 oxyanion strand; other site 215689009650 catalytic triad [active] 215689009651 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 215689009652 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 215689009653 catalytic residues [active] 215689009654 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 215689009655 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 215689009656 substrate binding site [chemical binding]; other site 215689009657 glutamase interaction surface [polypeptide binding]; other site 215689009658 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 215689009659 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 215689009660 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 215689009661 metal binding site [ion binding]; metal-binding site 215689009662 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 215689009663 putative deacylase active site [active] 215689009664 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 215689009665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689009666 substrate binding pocket [chemical binding]; other site 215689009667 membrane-bound complex binding site; other site 215689009668 hinge residues; other site 215689009669 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 215689009670 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 215689009671 active site 215689009672 Zn binding site [ion binding]; other site 215689009673 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 215689009674 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 215689009675 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 215689009676 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 215689009677 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 215689009678 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 215689009679 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 215689009680 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 215689009681 Ligand binding site; other site 215689009682 metal-binding site 215689009683 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 215689009684 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 215689009685 putative ADP-binding pocket [chemical binding]; other site 215689009686 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 215689009687 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 215689009688 active site 215689009689 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 215689009690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 215689009691 UDP-galactopyranose mutase; Region: GLF; pfam03275 215689009692 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 215689009693 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 215689009694 Walker A/P-loop; other site 215689009695 ATP binding site [chemical binding]; other site 215689009696 Q-loop/lid; other site 215689009697 ABC transporter signature motif; other site 215689009698 Walker B; other site 215689009699 D-loop; other site 215689009700 H-loop/switch region; other site 215689009701 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 215689009702 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 215689009703 UDP-glucose 4-epimerase; Region: PLN02240 215689009704 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 215689009705 NAD binding site [chemical binding]; other site 215689009706 homodimer interface [polypeptide binding]; other site 215689009707 active site 215689009708 substrate binding site [chemical binding]; other site 215689009709 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 215689009710 active site 215689009711 tetramer interface; other site 215689009712 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 215689009713 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 215689009714 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 215689009715 putative ADP-binding pocket [chemical binding]; other site 215689009716 colanic acid biosynthesis protein; Provisional; Region: PRK10017 215689009717 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 215689009718 Head binding; Region: Head_binding; pfam09008 215689009719 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 215689009720 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 215689009721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 215689009722 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 215689009723 putative ADP-binding pocket [chemical binding]; other site 215689009724 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 215689009725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 215689009726 active site 215689009727 Chain length determinant protein; Region: Wzz; pfam02706 215689009728 tyrosine kinase; Provisional; Region: PRK11519 215689009729 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 215689009730 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 215689009731 P loop; other site 215689009732 Nucleotide binding site [chemical binding]; other site 215689009733 DTAP/Switch II; other site 215689009734 Switch I; other site 215689009735 Low molecular weight phosphatase family; Region: LMWPc; cd00115 215689009736 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 215689009737 active site 215689009738 polysaccharide export protein Wza; Provisional; Region: PRK15078 215689009739 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 215689009740 SLBB domain; Region: SLBB; pfam10531 215689009741 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 215689009742 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 215689009743 Bacterial sugar transferase; Region: Bac_transf; pfam02397 215689009744 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 215689009745 FOG: CBS domain [General function prediction only]; Region: COG0517 215689009746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 215689009747 Transporter associated domain; Region: CorC_HlyC; smart01091 215689009748 putative assembly protein; Provisional; Region: PRK10833 215689009749 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 215689009750 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 215689009751 trimer interface [polypeptide binding]; other site 215689009752 active site 215689009753 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 215689009754 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 215689009755 ATP-binding site [chemical binding]; other site 215689009756 Sugar specificity; other site 215689009757 Pyrimidine base specificity; other site 215689009758 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 215689009759 active site 215689009760 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 215689009761 putative chaperone; Provisional; Region: PRK11678 215689009762 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 215689009763 nucleotide binding site [chemical binding]; other site 215689009764 putative NEF/HSP70 interaction site [polypeptide binding]; other site 215689009765 SBD interface [polypeptide binding]; other site 215689009766 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 215689009767 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 215689009768 active site 215689009769 catalytic tetrad [active] 215689009770 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 215689009771 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 215689009772 HlyD family secretion protein; Region: HlyD_3; pfam13437 215689009773 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 215689009774 Protein export membrane protein; Region: SecD_SecF; cl14618 215689009775 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 215689009776 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 215689009777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689009778 dimerization interface [polypeptide binding]; other site 215689009779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689009780 dimer interface [polypeptide binding]; other site 215689009781 phosphorylation site [posttranslational modification] 215689009782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689009783 ATP binding site [chemical binding]; other site 215689009784 Mg2+ binding site [ion binding]; other site 215689009785 G-X-G motif; other site 215689009786 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 215689009787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689009788 active site 215689009789 phosphorylation site [posttranslational modification] 215689009790 intermolecular recognition site; other site 215689009791 dimerization interface [polypeptide binding]; other site 215689009792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689009793 DNA binding site [nucleotide binding] 215689009794 lipid kinase; Reviewed; Region: PRK13054 215689009795 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 215689009796 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 215689009797 dimer interface [polypeptide binding]; other site 215689009798 substrate binding site [chemical binding]; other site 215689009799 ATP binding site [chemical binding]; other site 215689009800 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 215689009801 substrate binding site [chemical binding]; other site 215689009802 multimerization interface [polypeptide binding]; other site 215689009803 ATP binding site [chemical binding]; other site 215689009804 chorismate mutase; Provisional; Region: PRK08055 215689009805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 215689009806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689009807 Coenzyme A binding pocket [chemical binding]; other site 215689009808 antiporter inner membrane protein; Provisional; Region: PRK11670 215689009809 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 215689009810 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 215689009811 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 215689009812 active site 215689009813 HIGH motif; other site 215689009814 KMSKS motif; other site 215689009815 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 215689009816 tRNA binding surface [nucleotide binding]; other site 215689009817 anticodon binding site; other site 215689009818 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 215689009819 dimer interface [polypeptide binding]; other site 215689009820 putative tRNA-binding site [nucleotide binding]; other site 215689009821 hypothetical protein; Provisional; Region: PRK01821 215689009822 hypothetical protein; Provisional; Region: PRK10711 215689009823 cytidine deaminase; Provisional; Region: PRK09027 215689009824 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 215689009825 active site 215689009826 catalytic motif [active] 215689009827 Zn binding site [ion binding]; other site 215689009828 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 215689009829 malate dehydrogenase; Provisional; Region: PRK13529 215689009830 Malic enzyme, N-terminal domain; Region: malic; pfam00390 215689009831 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 215689009832 NAD(P) binding site [chemical binding]; other site 215689009833 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 215689009834 putative active site [active] 215689009835 potential frameshift: common BLAST hit: gi|188533435|ref|YP_001907232.1| beta-methylgalactoside transporter inner membrane protein 215689009836 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 215689009837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 215689009838 TM-ABC transporter signature motif; other site 215689009839 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 215689009840 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 215689009841 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 215689009842 DNA binding site [nucleotide binding] 215689009843 domain linker motif; other site 215689009844 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 215689009845 ABC transporter signature motif; other site 215689009846 Walker B; other site 215689009847 D-loop; other site 215689009848 H-loop/switch region; other site 215689009849 Predicted membrane protein [Function unknown]; Region: COG2311 215689009850 hypothetical protein; Provisional; Region: PRK10835 215689009851 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 215689009852 homodecamer interface [polypeptide binding]; other site 215689009853 GTP cyclohydrolase I; Provisional; Region: PLN03044 215689009854 active site 215689009855 putative catalytic site residues [active] 215689009856 zinc binding site [ion binding]; other site 215689009857 GTP-CH-I/GFRP interaction surface; other site 215689009858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689009859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689009860 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 215689009861 putative dimerization interface [polypeptide binding]; other site 215689009862 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 215689009863 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 215689009864 substrate binding site [chemical binding]; other site 215689009865 catalytic Zn binding site [ion binding]; other site 215689009866 NAD binding site [chemical binding]; other site 215689009867 structural Zn binding site [ion binding]; other site 215689009868 dimer interface [polypeptide binding]; other site 215689009869 S-formylglutathione hydrolase; Region: PLN02442 215689009870 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 215689009871 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 215689009872 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 215689009873 Walker A/P-loop; other site 215689009874 ATP binding site [chemical binding]; other site 215689009875 Q-loop/lid; other site 215689009876 ABC transporter signature motif; other site 215689009877 Walker B; other site 215689009878 D-loop; other site 215689009879 H-loop/switch region; other site 215689009880 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 215689009881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 215689009882 ABC-ATPase subunit interface; other site 215689009883 dimer interface [polypeptide binding]; other site 215689009884 putative PBP binding regions; other site 215689009885 lysine transporter; Provisional; Region: PRK10836 215689009886 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 215689009887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689009888 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 215689009889 putative dimerization interface [polypeptide binding]; other site 215689009890 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 215689009891 endonuclease IV; Provisional; Region: PRK01060 215689009892 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 215689009893 AP (apurinic/apyrimidinic) site pocket; other site 215689009894 DNA interaction; other site 215689009895 Metal-binding active site; metal-binding site 215689009896 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 215689009897 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 215689009898 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 215689009899 active site 215689009900 P-loop; other site 215689009901 phosphorylation site [posttranslational modification] 215689009902 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 215689009903 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 215689009904 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 215689009905 putative substrate binding site [chemical binding]; other site 215689009906 putative ATP binding site [chemical binding]; other site 215689009907 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 215689009908 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 215689009909 active site 215689009910 phosphorylation site [posttranslational modification] 215689009911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 215689009912 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 215689009913 dimerization domain swap beta strand [polypeptide binding]; other site 215689009914 regulatory protein interface [polypeptide binding]; other site 215689009915 active site 215689009916 regulatory phosphorylation site [posttranslational modification]; other site 215689009917 elongation factor P; Provisional; Region: PRK04542 215689009918 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 215689009919 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 215689009920 RNA binding site [nucleotide binding]; other site 215689009921 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 215689009922 RNA binding site [nucleotide binding]; other site 215689009923 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 215689009924 NlpC/P60 family; Region: NLPC_P60; pfam00877 215689009925 phage resistance protein; Provisional; Region: PRK10551 215689009926 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 215689009927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 215689009928 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 215689009929 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 215689009930 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 215689009931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689009932 dimer interface [polypeptide binding]; other site 215689009933 conserved gate region; other site 215689009934 putative PBP binding loops; other site 215689009935 ABC-ATPase subunit interface; other site 215689009936 microcin C ABC transporter permease; Provisional; Region: PRK15021 215689009937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689009938 dimer interface [polypeptide binding]; other site 215689009939 conserved gate region; other site 215689009940 ABC-ATPase subunit interface; other site 215689009941 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 215689009942 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689009943 Walker A/P-loop; other site 215689009944 ATP binding site [chemical binding]; other site 215689009945 Q-loop/lid; other site 215689009946 ABC transporter signature motif; other site 215689009947 Walker B; other site 215689009948 D-loop; other site 215689009949 H-loop/switch region; other site 215689009950 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 215689009951 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 215689009952 Walker A/P-loop; other site 215689009953 ATP binding site [chemical binding]; other site 215689009954 Q-loop/lid; other site 215689009955 ABC transporter signature motif; other site 215689009956 Walker B; other site 215689009957 D-loop; other site 215689009958 H-loop/switch region; other site 215689009959 hypothetical protein; Provisional; Region: PRK11835 215689009960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 215689009961 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 215689009962 putative substrate translocation pore; other site 215689009963 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 215689009964 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 215689009965 RNA binding surface [nucleotide binding]; other site 215689009966 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 215689009967 active site 215689009968 uracil binding [chemical binding]; other site 215689009969 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 215689009970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 215689009971 ATP binding site [chemical binding]; other site 215689009972 putative Mg++ binding site [ion binding]; other site 215689009973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 215689009974 nucleotide binding region [chemical binding]; other site 215689009975 ATP-binding site [chemical binding]; other site 215689009976 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 215689009977 5S rRNA interface [nucleotide binding]; other site 215689009978 CTC domain interface [polypeptide binding]; other site 215689009979 L16 interface [polypeptide binding]; other site 215689009980 Nucleoid-associated protein [General function prediction only]; Region: COG3081 215689009981 nucleoid-associated protein NdpA; Validated; Region: PRK00378 215689009982 hypothetical protein; Provisional; Region: PRK13689 215689009983 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 215689009984 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 215689009985 Sulfatase; Region: Sulfatase; cl17466 215689009986 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 215689009987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 215689009988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 215689009989 Integrase core domain; Region: rve; pfam00665 215689009990 Integrase core domain; Region: rve_3; pfam13683 215689009991 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 215689009992 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 215689009993 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 215689009994 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 215689009995 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 215689009996 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 215689009997 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 215689009998 metal binding site [ion binding]; metal-binding site 215689009999 dimer interface [polypeptide binding]; other site 215689010000 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 215689010001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689010002 substrate binding pocket [chemical binding]; other site 215689010003 membrane-bound complex binding site; other site 215689010004 hinge residues; other site 215689010005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689010006 Coenzyme A binding pocket [chemical binding]; other site 215689010007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689010008 dimer interface [polypeptide binding]; other site 215689010009 conserved gate region; other site 215689010010 putative PBP binding loops; other site 215689010011 ABC-ATPase subunit interface; other site 215689010012 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 215689010013 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 215689010014 Walker A/P-loop; other site 215689010015 ATP binding site [chemical binding]; other site 215689010016 Q-loop/lid; other site 215689010017 ABC transporter signature motif; other site 215689010018 Walker B; other site 215689010019 D-loop; other site 215689010020 H-loop/switch region; other site 215689010021 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 215689010022 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 215689010023 Walker A/P-loop; other site 215689010024 ATP binding site [chemical binding]; other site 215689010025 Q-loop/lid; other site 215689010026 ABC transporter signature motif; other site 215689010027 Walker B; other site 215689010028 D-loop; other site 215689010029 H-loop/switch region; other site 215689010030 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 215689010031 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 215689010032 ApbE family; Region: ApbE; pfam02424 215689010033 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 215689010034 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 215689010035 trimer interface [polypeptide binding]; other site 215689010036 eyelet of channel; other site 215689010037 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 215689010038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689010039 ATP binding site [chemical binding]; other site 215689010040 Mg2+ binding site [ion binding]; other site 215689010041 G-X-G motif; other site 215689010042 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 215689010043 putative binding surface; other site 215689010044 active site 215689010045 transcriptional regulator RcsB; Provisional; Region: PRK10840 215689010046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689010047 active site 215689010048 phosphorylation site [posttranslational modification] 215689010049 intermolecular recognition site; other site 215689010050 dimerization interface [polypeptide binding]; other site 215689010051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689010052 DNA binding residues [nucleotide binding] 215689010053 dimerization interface [polypeptide binding]; other site 215689010054 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 215689010055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689010056 dimer interface [polypeptide binding]; other site 215689010057 phosphorylation site [posttranslational modification] 215689010058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689010059 ATP binding site [chemical binding]; other site 215689010060 Mg2+ binding site [ion binding]; other site 215689010061 G-X-G motif; other site 215689010062 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 215689010063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689010064 active site 215689010065 phosphorylation site [posttranslational modification] 215689010066 intermolecular recognition site; other site 215689010067 dimerization interface [polypeptide binding]; other site 215689010068 DNA gyrase subunit A; Validated; Region: PRK05560 215689010069 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 215689010070 CAP-like domain; other site 215689010071 active site 215689010072 primary dimer interface [polypeptide binding]; other site 215689010073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 215689010074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 215689010075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 215689010076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 215689010077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 215689010078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 215689010079 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 215689010080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689010081 S-adenosylmethionine binding site [chemical binding]; other site 215689010082 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 215689010083 ATP cone domain; Region: ATP-cone; pfam03477 215689010084 Class I ribonucleotide reductase; Region: RNR_I; cd01679 215689010085 active site 215689010086 dimer interface [polypeptide binding]; other site 215689010087 catalytic residues [active] 215689010088 effector binding site; other site 215689010089 R2 peptide binding site; other site 215689010090 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 215689010091 dimer interface [polypeptide binding]; other site 215689010092 putative radical transfer pathway; other site 215689010093 diiron center [ion binding]; other site 215689010094 tyrosyl radical; other site 215689010095 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 215689010096 catalytic loop [active] 215689010097 iron binding site [ion binding]; other site 215689010098 hypothetical protein; Provisional; Region: PRK03673 215689010099 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 215689010100 putative MPT binding site; other site 215689010101 Competence-damaged protein; Region: CinA; cl00666 215689010102 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 215689010103 putative catalytic site [active] 215689010104 putative metal binding site [ion binding]; other site 215689010105 putative phosphate binding site [ion binding]; other site 215689010106 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 215689010107 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 215689010108 active site 215689010109 homotetramer interface [polypeptide binding]; other site 215689010110 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 215689010111 potassium uptake protein; Region: kup; TIGR00794 215689010112 hypothetical protein; Provisional; Region: PRK10404 215689010113 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 215689010114 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 215689010115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689010116 Coenzyme A binding pocket [chemical binding]; other site 215689010117 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 215689010118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 215689010119 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 215689010120 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 215689010121 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 215689010122 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 215689010123 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 215689010124 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 215689010125 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 215689010126 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 215689010127 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 215689010128 4Fe-4S binding domain; Region: Fer4; pfam00037 215689010129 4Fe-4S binding domain; Region: Fer4; pfam00037 215689010130 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 215689010131 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 215689010132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 215689010133 catalytic loop [active] 215689010134 iron binding site [ion binding]; other site 215689010135 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 215689010136 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 215689010137 [4Fe-4S] binding site [ion binding]; other site 215689010138 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 215689010139 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 215689010140 SLBB domain; Region: SLBB; pfam10531 215689010141 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 215689010142 NADH dehydrogenase subunit E; Validated; Region: PRK07539 215689010143 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 215689010144 putative dimer interface [polypeptide binding]; other site 215689010145 [2Fe-2S] cluster binding site [ion binding]; other site 215689010146 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 215689010147 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 215689010148 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 215689010149 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 215689010150 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 215689010151 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 215689010152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689010153 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 215689010154 putative dimerization interface [polypeptide binding]; other site 215689010155 aminotransferase AlaT; Validated; Region: PRK09265 215689010156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689010157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689010158 homodimer interface [polypeptide binding]; other site 215689010159 catalytic residue [active] 215689010160 5'-nucleotidase; Provisional; Region: PRK03826 215689010161 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 215689010162 putative phosphatase; Provisional; Region: PRK11587 215689010163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 215689010164 motif II; other site 215689010165 hypothetical protein; Provisional; Region: PRK01816 215689010166 propionate/acetate kinase; Provisional; Region: PRK12379 215689010167 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 215689010168 phosphate acetyltransferase; Reviewed; Region: PRK05632 215689010169 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 215689010170 DRTGG domain; Region: DRTGG; pfam07085 215689010171 phosphate acetyltransferase; Region: pta; TIGR00651 215689010172 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 215689010173 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 215689010174 Walker A/P-loop; other site 215689010175 ATP binding site [chemical binding]; other site 215689010176 Q-loop/lid; other site 215689010177 ABC transporter signature motif; other site 215689010178 Walker B; other site 215689010179 D-loop; other site 215689010180 H-loop/switch region; other site 215689010181 TOBE domain; Region: TOBE_2; pfam08402 215689010182 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 215689010183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689010184 DNA-binding site [nucleotide binding]; DNA binding site 215689010185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689010186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689010187 homodimer interface [polypeptide binding]; other site 215689010188 catalytic residue [active] 215689010189 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 215689010190 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 215689010191 inhibitor-cofactor binding pocket; inhibition site 215689010192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689010193 catalytic residue [active] 215689010194 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 215689010195 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 215689010196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689010197 dimer interface [polypeptide binding]; other site 215689010198 conserved gate region; other site 215689010199 putative PBP binding loops; other site 215689010200 ABC-ATPase subunit interface; other site 215689010201 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 215689010202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689010203 dimer interface [polypeptide binding]; other site 215689010204 conserved gate region; other site 215689010205 putative PBP binding loops; other site 215689010206 ABC-ATPase subunit interface; other site 215689010207 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 215689010208 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 215689010209 nudix motif; other site 215689010210 glutathione S-transferase; Provisional; Region: PRK15113 215689010211 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 215689010212 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 215689010213 putative NAD(P) binding site [chemical binding]; other site 215689010214 putative active site [active] 215689010215 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 215689010216 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 215689010217 Walker A/P-loop; other site 215689010218 ATP binding site [chemical binding]; other site 215689010219 Q-loop/lid; other site 215689010220 ABC transporter signature motif; other site 215689010221 Walker B; other site 215689010222 D-loop; other site 215689010223 H-loop/switch region; other site 215689010224 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 215689010225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689010226 dimer interface [polypeptide binding]; other site 215689010227 conserved gate region; other site 215689010228 putative PBP binding loops; other site 215689010229 ABC-ATPase subunit interface; other site 215689010230 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 215689010231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689010232 dimer interface [polypeptide binding]; other site 215689010233 conserved gate region; other site 215689010234 putative PBP binding loops; other site 215689010235 ABC-ATPase subunit interface; other site 215689010236 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 215689010237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 215689010238 substrate binding pocket [chemical binding]; other site 215689010239 membrane-bound complex binding site; other site 215689010240 hinge residues; other site 215689010241 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 215689010242 Flavoprotein; Region: Flavoprotein; pfam02441 215689010243 amidophosphoribosyltransferase; Provisional; Region: PRK09246 215689010244 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 215689010245 active site 215689010246 tetramer interface [polypeptide binding]; other site 215689010247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 215689010248 active site 215689010249 colicin V production protein; Provisional; Region: PRK10845 215689010250 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 215689010251 cell division protein DedD; Provisional; Region: PRK11633 215689010252 Sporulation related domain; Region: SPOR; pfam05036 215689010253 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 215689010254 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 215689010255 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 215689010256 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 215689010257 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 215689010258 hypothetical protein; Provisional; Region: PRK10847 215689010259 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 215689010260 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 215689010261 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 215689010262 dimerization interface 3.5A [polypeptide binding]; other site 215689010263 active site 215689010264 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 215689010265 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 215689010266 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 215689010267 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 215689010268 ligand binding site [chemical binding]; other site 215689010269 NAD binding site [chemical binding]; other site 215689010270 catalytic site [active] 215689010271 homodimer interface [polypeptide binding]; other site 215689010272 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 215689010273 EamA-like transporter family; Region: EamA; pfam00892 215689010274 EamA-like transporter family; Region: EamA; pfam00892 215689010275 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 215689010276 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 215689010277 active site residue [active] 215689010278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 215689010279 DNA-binding site [nucleotide binding]; DNA binding site 215689010280 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 215689010281 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689010282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689010283 homodimer interface [polypeptide binding]; other site 215689010284 catalytic residue [active] 215689010285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 215689010286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 215689010287 catalytic residue [active] 215689010288 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 215689010289 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 215689010290 dimer interface [polypeptide binding]; other site 215689010291 active site 215689010292 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 215689010293 Uncharacterized conserved protein [Function unknown]; Region: COG4121 215689010294 YfcL protein; Region: YfcL; pfam08891 215689010295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 215689010296 hypothetical protein; Provisional; Region: PRK10621 215689010297 Predicted permeases [General function prediction only]; Region: COG0730 215689010298 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 215689010299 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 215689010300 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 215689010301 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 215689010302 Tetramer interface [polypeptide binding]; other site 215689010303 active site 215689010304 FMN-binding site [chemical binding]; other site 215689010305 HemK family putative methylases; Region: hemK_fam; TIGR00536 215689010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 215689010307 S-adenosylmethionine binding site [chemical binding]; other site 215689010308 hypothetical protein; Provisional; Region: PRK04946 215689010309 Smr domain; Region: Smr; pfam01713 215689010310 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 215689010311 catalytic core [active] 215689010312 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 215689010313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 215689010314 substrate binding site [chemical binding]; other site 215689010315 oxyanion hole (OAH) forming residues; other site 215689010316 trimer interface [polypeptide binding]; other site 215689010317 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 215689010318 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 215689010319 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 215689010320 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 215689010321 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 215689010322 dimer interface [polypeptide binding]; other site 215689010323 active site 215689010324 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 215689010325 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 215689010326 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 215689010327 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 215689010328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 215689010329 binding surface 215689010330 TPR motif; other site 215689010331 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 215689010332 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 215689010333 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 215689010334 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 215689010335 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 215689010336 heme exporter protein CcmC; Region: ccmC; TIGR01191 215689010337 heme exporter protein CcmB; Region: ccmB; TIGR01190 215689010338 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 215689010339 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 215689010340 Walker A/P-loop; other site 215689010341 ATP binding site [chemical binding]; other site 215689010342 Q-loop/lid; other site 215689010343 ABC transporter signature motif; other site 215689010344 Walker B; other site 215689010345 D-loop; other site 215689010346 H-loop/switch region; other site 215689010347 BetR domain; Region: BetR; pfam08667 215689010348 Response regulator receiver domain; Region: Response_reg; pfam00072 215689010349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689010350 active site 215689010351 phosphorylation site [posttranslational modification] 215689010352 intermolecular recognition site; other site 215689010353 dimerization interface [polypeptide binding]; other site 215689010354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689010355 Coenzyme A binding pocket [chemical binding]; other site 215689010356 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 215689010357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 215689010358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689010359 ATP binding site [chemical binding]; other site 215689010360 Mg2+ binding site [ion binding]; other site 215689010361 G-X-G motif; other site 215689010362 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 215689010363 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 215689010364 putative active site [active] 215689010365 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 215689010366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689010367 Transposase; Region: HTH_Tnp_1; pfam01527 215689010368 putative transposase OrfB; Reviewed; Region: PHA02517 215689010369 HTH-like domain; Region: HTH_21; pfam13276 215689010370 Integrase core domain; Region: rve; pfam00665 215689010371 Integrase core domain; Region: rve_3; pfam13683 215689010372 Integrase core domain; Region: rve; pfam00665 215689010373 Integrase core domain; Region: rve_3; pfam13683 215689010374 putative transposase OrfB; Reviewed; Region: PHA02517 215689010375 HTH-like domain; Region: HTH_21; pfam13276 215689010376 Integrase core domain; Region: rve; pfam00665 215689010377 Integrase core domain; Region: rve_3; pfam13683 215689010378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 215689010379 Transposase; Region: HTH_Tnp_1; pfam01527 215689010380 potential frameshift: common BLAST hit: gi|292486501|ref|YP_003529367.1| glucosyltransferase-I 215689010381 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 215689010382 Mechanosensitive ion channel; Region: MS_channel; pfam00924 215689010383 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 215689010384 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 215689010385 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 215689010386 Ligand Binding Site [chemical binding]; other site 215689010387 SopA-like central domain; Region: SopA; pfam13981 215689010388 SopA-like catalytic domain; Region: SopA_C; pfam13979 215689010389 aminotransferase; Validated; Region: PRK08175 215689010390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 215689010391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689010392 homodimer interface [polypeptide binding]; other site 215689010393 catalytic residue [active] 215689010394 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 215689010395 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 215689010396 LytTr DNA-binding domain; Region: LytTR; pfam04397 215689010397 glucokinase; Provisional; Region: glk; PRK00292 215689010398 glucokinase, proteobacterial type; Region: glk; TIGR00749 215689010399 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 215689010400 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 215689010401 dimer interface [polypeptide binding]; other site 215689010402 PYR/PP interface [polypeptide binding]; other site 215689010403 TPP binding site [chemical binding]; other site 215689010404 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 215689010405 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 215689010406 TPP-binding site [chemical binding]; other site 215689010407 dimer interface [polypeptide binding]; other site 215689010408 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 215689010409 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 215689010410 active site 215689010411 catalytic tetrad [active] 215689010412 manganese transport protein MntH; Reviewed; Region: PRK00701 215689010413 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 215689010414 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 215689010415 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 215689010416 Nucleoside recognition; Region: Gate; pfam07670 215689010417 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 215689010418 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 215689010419 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 215689010420 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 215689010421 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 215689010422 active site 215689010423 HIGH motif; other site 215689010424 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 215689010425 active site 215689010426 KMSKS motif; other site 215689010427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 215689010428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 215689010429 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 215689010430 putative dimerization interface [polypeptide binding]; other site 215689010431 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 215689010432 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 215689010433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 215689010434 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 215689010435 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 215689010436 nucleotide binding pocket [chemical binding]; other site 215689010437 K-X-D-G motif; other site 215689010438 catalytic site [active] 215689010439 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 215689010440 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 215689010441 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 215689010442 Dimer interface [polypeptide binding]; other site 215689010443 BRCT sequence motif; other site 215689010444 cell division protein ZipA; Provisional; Region: PRK03427 215689010445 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 215689010446 FtsZ protein binding site [polypeptide binding]; other site 215689010447 putative sulfate transport protein CysZ; Validated; Region: PRK04949 215689010448 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 215689010449 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 215689010450 dimer interface [polypeptide binding]; other site 215689010451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689010452 catalytic residue [active] 215689010453 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 215689010454 dimerization domain swap beta strand [polypeptide binding]; other site 215689010455 regulatory protein interface [polypeptide binding]; other site 215689010456 active site 215689010457 regulatory phosphorylation site [posttranslational modification]; other site 215689010458 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 215689010459 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 215689010460 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 215689010461 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 215689010462 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 215689010463 HPr interaction site; other site 215689010464 glycerol kinase (GK) interaction site [polypeptide binding]; other site 215689010465 active site 215689010466 phosphorylation site [posttranslational modification] 215689010467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 215689010468 dimerization interface [polypeptide binding]; other site 215689010469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 215689010470 dimer interface [polypeptide binding]; other site 215689010471 phosphorylation site [posttranslational modification] 215689010472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689010473 ATP binding site [chemical binding]; other site 215689010474 Mg2+ binding site [ion binding]; other site 215689010475 G-X-G motif; other site 215689010476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 215689010477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689010478 active site 215689010479 phosphorylation site [posttranslational modification] 215689010480 intermolecular recognition site; other site 215689010481 dimerization interface [polypeptide binding]; other site 215689010482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 215689010483 DNA binding site [nucleotide binding] 215689010484 cysteine synthase B; Region: cysM; TIGR01138 215689010485 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 215689010486 dimer interface [polypeptide binding]; other site 215689010487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 215689010488 catalytic residue [active] 215689010489 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 215689010490 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 215689010491 Walker A/P-loop; other site 215689010492 ATP binding site [chemical binding]; other site 215689010493 Q-loop/lid; other site 215689010494 ABC transporter signature motif; other site 215689010495 Walker B; other site 215689010496 D-loop; other site 215689010497 H-loop/switch region; other site 215689010498 TOBE-like domain; Region: TOBE_3; pfam12857 215689010499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689010500 dimer interface [polypeptide binding]; other site 215689010501 conserved gate region; other site 215689010502 putative PBP binding loops; other site 215689010503 ABC-ATPase subunit interface; other site 215689010504 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 215689010505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 215689010506 dimer interface [polypeptide binding]; other site 215689010507 conserved gate region; other site 215689010508 putative PBP binding loops; other site 215689010509 ABC-ATPase subunit interface; other site 215689010510 thiosulfate transporter subunit; Provisional; Region: PRK10852 215689010511 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 215689010512 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 215689010513 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 215689010514 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 215689010515 putative acetyltransferase; Provisional; Region: PRK03624 215689010516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 215689010517 Coenzyme A binding pocket [chemical binding]; other site 215689010518 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 215689010519 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 215689010520 active site 215689010521 metal binding site [ion binding]; metal-binding site 215689010522 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 215689010523 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 215689010524 transaldolase-like protein; Provisional; Region: PTZ00411 215689010525 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 215689010526 active site 215689010527 dimer interface [polypeptide binding]; other site 215689010528 catalytic residue [active] 215689010529 transketolase; Reviewed; Region: PRK12753 215689010530 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 215689010531 TPP-binding site [chemical binding]; other site 215689010532 dimer interface [polypeptide binding]; other site 215689010533 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 215689010534 PYR/PP interface [polypeptide binding]; other site 215689010535 dimer interface [polypeptide binding]; other site 215689010536 TPP binding site [chemical binding]; other site 215689010537 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 215689010538 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 215689010539 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 215689010540 dimer interface [polypeptide binding]; other site 215689010541 ADP-ribose binding site [chemical binding]; other site 215689010542 active site 215689010543 nudix motif; other site 215689010544 metal binding site [ion binding]; metal-binding site 215689010545 L-asparagine permease; Provisional; Region: PRK15049 215689010546 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 215689010547 Histidine kinase; Region: HisKA_3; pfam07730 215689010548 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 215689010549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 215689010550 ATP binding site [chemical binding]; other site 215689010551 Mg2+ binding site [ion binding]; other site 215689010552 G-X-G motif; other site 215689010553 transcriptional regulator NarP; Provisional; Region: PRK10403 215689010554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 215689010555 active site 215689010556 phosphorylation site [posttranslational modification] 215689010557 intermolecular recognition site; other site 215689010558 dimerization interface [polypeptide binding]; other site 215689010559 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 215689010560 DNA binding residues [nucleotide binding] 215689010561 dimerization interface [polypeptide binding]; other site 215689010562 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 215689010563 Protein export membrane protein; Region: SecD_SecF; cl14618 215689010564 Colicin pore forming domain; Region: Colicin; pfam01024 215689010565 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 215689010566 ArsC family; Region: ArsC; pfam03960 215689010567 putative catalytic residues [active] 215689010568 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 215689010569 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 215689010570 metal binding site [ion binding]; metal-binding site 215689010571 dimer interface [polypeptide binding]; other site 215689010572 hypothetical protein; Provisional; Region: PRK13664 215689010573 Condensation domain; Region: Condensation; pfam00668 215689010574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 215689010575 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 215689010576 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 215689010577 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 215689010578 acyl-activating enzyme (AAE) consensus motif; other site 215689010579 AMP binding site [chemical binding]; other site 215689010580 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 215689010581 Condensation domain; Region: Condensation; pfam00668 215689010582 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 215689010583 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 215689010584 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 215689010585 acyl-activating enzyme (AAE) consensus motif; other site 215689010586 AMP binding site [chemical binding]; other site 215689010587 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 215689010588 Condensation domain; Region: Condensation; pfam00668 215689010589 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 215689010590 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 215689010591 acyl-activating enzyme (AAE) consensus motif; other site 215689010592 AMP binding site [chemical binding]; other site 215689010593 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 215689010594 Condensation domain; Region: Condensation; pfam00668 215689010595 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 215689010596 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 215689010597 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 215689010598 acyl-activating enzyme (AAE) consensus motif; other site 215689010599 AMP binding site [chemical binding]; other site 215689010600 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 215689010601 Condensation domain; Region: Condensation; pfam00668 215689010602 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 215689010603 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 215689010604 acyl-activating enzyme (AAE) consensus motif; other site 215689010605 AMP binding site [chemical binding]; other site 215689010606 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 215689010607 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 215689010608 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 215689010609 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 215689010610 RHS Repeat; Region: RHS_repeat; cl11982 215689010611 RHS Repeat; Region: RHS_repeat; cl11982 215689010612 RHS protein; Region: RHS; pfam03527 215689010613 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689010614 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689010615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 215689010616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 215689010617 non-specific DNA binding site [nucleotide binding]; other site 215689010618 salt bridge; other site 215689010619 sequence-specific DNA binding site [nucleotide binding]; other site 215689010620 potential frameshift: common BLAST hit: gi|259909786|ref|YP_002650142.1| Dnag primase-like protein 215689010621 CHC2 zinc finger; Region: zf-CHC2; cl17510 215689010622 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 215689010623 Toprim-like; Region: Toprim_2; pfam13155 215689010624 active site 215689010625 metal binding site [ion binding]; metal-binding site 215689010626 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 215689010627 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 215689010628 active site 215689010629 DNA binding site [nucleotide binding] 215689010630 Int/Topo IB signature motif; other site 215689010631 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 215689010632 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 215689010633 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 215689010634 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 215689010635 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 215689010636 Helicase; Region: Helicase_RecD; pfam05127 215689010637 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 215689010638 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 215689010639 Predicted metalloprotease [General function prediction only]; Region: COG2321 215689010640 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 215689010641 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 215689010642 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 215689010643 ATP binding site [chemical binding]; other site 215689010644 active site 215689010645 substrate binding site [chemical binding]; other site 215689010646 lipoprotein; Provisional; Region: PRK11679 215689010647 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 215689010648 dihydrodipicolinate synthase; Region: dapA; TIGR00674 215689010649 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 215689010650 dimer interface [polypeptide binding]; other site 215689010651 active site 215689010652 catalytic residue [active] 215689010653 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 215689010654 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 215689010655 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 215689010656 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 215689010657 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 215689010658 catalytic triad [active] 215689010659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 215689010660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 215689010661 metal binding site [ion binding]; metal-binding site 215689010662 active site 215689010663 I-site; other site 215689010664 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 215689010665 Peptidase family M48; Region: Peptidase_M48; pfam01435 215689010666 PAAR motif; Region: PAAR_motif; pfam05488 215689010667 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 215689010668 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786