-- dump date 20140619_075437 -- class Genbank::misc_feature -- table misc_feature_note -- id note 644651000001 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 644651000002 catalytic residue [active] 644651000003 Protein of unknown function (DUF796); Region: DUF796; pfam05638 644651000004 Rop protein; Region: Rop; pfam01815 644651000005 Protein of unknown function (DUF796); Region: DUF796; pfam05638 644651000006 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 644651000007 catalytic residue [active] 644651000008 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 644651000009 MbeD/MobD like; Region: MbeD_MobD; pfam04899 644651000010 MbeB-like, N-term conserved region; Region: MbeB_N; pfam04837 644651000011 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 644651000012 FMN-binding protein MioC; Provisional; Region: PRK09004 644651000013 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 644651000014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644651000015 putative DNA binding site [nucleotide binding]; other site 644651000016 putative Zn2+ binding site [ion binding]; other site 644651000017 AsnC family; Region: AsnC_trans_reg; pfam01037 644651000018 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 644651000019 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 644651000020 Methyltransferase domain; Region: Methyltransf_23; pfam13489 644651000021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651000022 S-adenosylmethionine binding site [chemical binding]; other site 644651000023 hypothetical protein; Provisional; Region: yieM; PRK10997 644651000024 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 644651000025 metal ion-dependent adhesion site (MIDAS); other site 644651000026 regulatory ATPase RavA; Provisional; Region: PRK13531 644651000027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651000028 Walker A motif; other site 644651000029 ATP binding site [chemical binding]; other site 644651000030 Walker B motif; other site 644651000031 arginine finger; other site 644651000032 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 644651000033 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 644651000034 potassium uptake protein; Region: kup; TIGR00794 644651000035 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 644651000036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651000037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651000038 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 644651000039 putative dimerization interface [polypeptide binding]; other site 644651000040 putative substrate binding pocket [chemical binding]; other site 644651000041 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 644651000042 acetolactate synthase; Reviewed; Region: PRK08617 644651000043 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644651000044 PYR/PP interface [polypeptide binding]; other site 644651000045 dimer interface [polypeptide binding]; other site 644651000046 TPP binding site [chemical binding]; other site 644651000047 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644651000048 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 644651000049 TPP-binding site [chemical binding]; other site 644651000050 D-ribose pyranase; Provisional; Region: PRK11797 644651000051 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 644651000052 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 644651000053 Walker A/P-loop; other site 644651000054 ATP binding site [chemical binding]; other site 644651000055 Q-loop/lid; other site 644651000056 ABC transporter signature motif; other site 644651000057 Walker B; other site 644651000058 D-loop; other site 644651000059 H-loop/switch region; other site 644651000060 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 644651000061 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644651000062 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 644651000063 TM-ABC transporter signature motif; other site 644651000064 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 644651000065 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 644651000066 ligand binding site [chemical binding]; other site 644651000067 dimerization interface [polypeptide binding]; other site 644651000068 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644651000069 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 644651000070 substrate binding site [chemical binding]; other site 644651000071 dimer interface [polypeptide binding]; other site 644651000072 ATP binding site [chemical binding]; other site 644651000073 transcriptional repressor RbsR; Provisional; Region: PRK10423 644651000074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651000075 DNA binding site [nucleotide binding] 644651000076 domain linker motif; other site 644651000077 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 644651000078 dimerization interface [polypeptide binding]; other site 644651000079 ligand binding site [chemical binding]; other site 644651000080 putative transporter; Provisional; Region: PRK10504 644651000081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651000082 putative substrate translocation pore; other site 644651000083 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 644651000084 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 644651000085 GTP binding site; other site 644651000086 serine/threonine protein kinase; Provisional; Region: PRK11768 644651000087 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 644651000088 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 644651000089 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 644651000090 catalytic residues [active] 644651000091 hinge region; other site 644651000092 alpha helical domain; other site 644651000093 DNA polymerase I; Provisional; Region: PRK05755 644651000094 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 644651000095 active site 644651000096 metal binding site 1 [ion binding]; metal-binding site 644651000097 putative 5' ssDNA interaction site; other site 644651000098 metal binding site 3; metal-binding site 644651000099 metal binding site 2 [ion binding]; metal-binding site 644651000100 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 644651000101 putative DNA binding site [nucleotide binding]; other site 644651000102 putative metal binding site [ion binding]; other site 644651000103 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 644651000104 active site 644651000105 catalytic site [active] 644651000106 substrate binding site [chemical binding]; other site 644651000107 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 644651000108 active site 644651000109 DNA binding site [nucleotide binding] 644651000110 catalytic site [active] 644651000111 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 644651000112 G1 box; other site 644651000113 GTP/Mg2+ binding site [chemical binding]; other site 644651000114 Switch I region; other site 644651000115 G2 box; other site 644651000116 G3 box; other site 644651000117 Switch II region; other site 644651000118 G4 box; other site 644651000119 G5 box; other site 644651000120 Der GTPase activator; Provisional; Region: PRK05244 644651000121 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 644651000122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651000123 FeS/SAM binding site; other site 644651000124 HemN C-terminal domain; Region: HemN_C; pfam06969 644651000125 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 644651000126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651000127 active site 644651000128 phosphorylation site [posttranslational modification] 644651000129 intermolecular recognition site; other site 644651000130 dimerization interface [polypeptide binding]; other site 644651000131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651000132 Walker A motif; other site 644651000133 ATP binding site [chemical binding]; other site 644651000134 Walker B motif; other site 644651000135 arginine finger; other site 644651000136 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 644651000137 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 644651000138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 644651000139 putative active site [active] 644651000140 heme pocket [chemical binding]; other site 644651000141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651000142 dimer interface [polypeptide binding]; other site 644651000143 phosphorylation site [posttranslational modification] 644651000144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651000145 ATP binding site [chemical binding]; other site 644651000146 Mg2+ binding site [ion binding]; other site 644651000147 G-X-G motif; other site 644651000148 glutamine synthetase; Provisional; Region: glnA; PRK09469 644651000149 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 644651000150 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 644651000151 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 644651000152 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 644651000153 G1 box; other site 644651000154 putative GEF interaction site [polypeptide binding]; other site 644651000155 GTP/Mg2+ binding site [chemical binding]; other site 644651000156 Switch I region; other site 644651000157 G2 box; other site 644651000158 G3 box; other site 644651000159 Switch II region; other site 644651000160 G4 box; other site 644651000161 G5 box; other site 644651000162 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 644651000163 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 644651000164 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 644651000165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651000166 motif II; other site 644651000167 hypothetical protein; Reviewed; Region: PRK01637 644651000168 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 644651000169 putative active site [active] 644651000170 dimerization interface [polypeptide binding]; other site 644651000171 putative tRNAtyr binding site [nucleotide binding]; other site 644651000172 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644651000173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651000174 Coenzyme A binding pocket [chemical binding]; other site 644651000175 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 644651000176 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 644651000177 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651000178 RNA binding surface [nucleotide binding]; other site 644651000179 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 644651000180 probable active site [active] 644651000181 AsmA family; Region: AsmA; pfam05170 644651000182 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 644651000183 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 644651000184 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 644651000185 generic binding surface II; other site 644651000186 ssDNA binding site; other site 644651000187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651000188 ATP binding site [chemical binding]; other site 644651000189 putative Mg++ binding site [ion binding]; other site 644651000190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651000191 nucleotide binding region [chemical binding]; other site 644651000192 ATP-binding site [chemical binding]; other site 644651000193 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 644651000194 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644651000195 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 644651000196 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 644651000197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644651000198 Zn2+ binding site [ion binding]; other site 644651000199 Mg2+ binding site [ion binding]; other site 644651000200 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 644651000201 synthetase active site [active] 644651000202 NTP binding site [chemical binding]; other site 644651000203 metal binding site [ion binding]; metal-binding site 644651000204 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 644651000205 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 644651000206 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 644651000207 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 644651000208 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 644651000209 catalytic site [active] 644651000210 G-X2-G-X-G-K; other site 644651000211 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 644651000212 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 644651000213 nucleotide binding pocket [chemical binding]; other site 644651000214 K-X-D-G motif; other site 644651000215 catalytic site [active] 644651000216 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 644651000217 Predicted membrane protein [Function unknown]; Region: COG2860 644651000218 UPF0126 domain; Region: UPF0126; pfam03458 644651000219 UPF0126 domain; Region: UPF0126; pfam03458 644651000220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644651000221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651000222 active site 644651000223 phosphorylation site [posttranslational modification] 644651000224 intermolecular recognition site; other site 644651000225 dimerization interface [polypeptide binding]; other site 644651000226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651000227 DNA binding residues [nucleotide binding] 644651000228 dimerization interface [polypeptide binding]; other site 644651000229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651000230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644651000231 putative substrate translocation pore; other site 644651000232 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 644651000233 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 644651000234 PhnA protein; Region: PhnA; pfam03831 644651000235 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 644651000236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 644651000237 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl17533 644651000238 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 644651000239 active site 644651000240 metal binding site [ion binding]; metal-binding site 644651000241 interdomain interaction site; other site 644651000242 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 644651000243 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651000244 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 644651000245 Prophage antirepressor [Transcription]; Region: COG3617 644651000246 BRO family, N-terminal domain; Region: Bro-N; smart01040 644651000247 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 644651000248 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 644651000249 active site 644651000250 Int/Topo IB signature motif; other site 644651000251 Homeodomain-like domain; Region: HTH_23; pfam13384 644651000252 Winged helix-turn helix; Region: HTH_29; pfam13551 644651000253 Homeodomain-like domain; Region: HTH_32; pfam13565 644651000254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651000255 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651000256 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 644651000257 hypothetical protein; Provisional; Region: PRK11820 644651000258 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 644651000259 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 644651000260 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 644651000261 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 644651000262 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 644651000263 Nucleoside recognition; Region: Gate; pfam07670 644651000264 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 644651000265 ribonuclease PH; Reviewed; Region: rph; PRK00173 644651000266 Ribonuclease PH; Region: RNase_PH_bact; cd11362 644651000267 hexamer interface [polypeptide binding]; other site 644651000268 active site 644651000269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651000270 active site 644651000271 division inhibitor protein; Provisional; Region: slmA; PRK09480 644651000272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651000273 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 644651000274 trimer interface [polypeptide binding]; other site 644651000275 active site 644651000276 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 644651000277 Flavoprotein; Region: Flavoprotein; pfam02441 644651000278 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 644651000279 hypothetical protein; Reviewed; Region: PRK00024 644651000280 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 644651000281 MPN+ (JAMM) motif; other site 644651000282 Zinc-binding site [ion binding]; other site 644651000283 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 644651000284 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 644651000285 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 644651000286 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 644651000287 DNA binding site [nucleotide binding] 644651000288 catalytic residue [active] 644651000289 H2TH interface [polypeptide binding]; other site 644651000290 putative catalytic residues [active] 644651000291 turnover-facilitating residue; other site 644651000292 intercalation triad [nucleotide binding]; other site 644651000293 8OG recognition residue [nucleotide binding]; other site 644651000294 putative reading head residues; other site 644651000295 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 644651000296 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644651000297 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 644651000298 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 644651000299 active site 644651000300 (T/H)XGH motif; other site 644651000301 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 644651000302 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 644651000303 putative metal binding site; other site 644651000304 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 644651000305 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 644651000306 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 644651000307 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 644651000308 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 644651000309 putative active site [active] 644651000310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644651000311 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 644651000312 putative ADP-binding pocket [chemical binding]; other site 644651000313 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 644651000314 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 644651000315 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 644651000316 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 644651000317 putative active site [active] 644651000318 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 644651000319 putative active site [active] 644651000320 putative catalytic site [active] 644651000321 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 644651000322 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 644651000323 putative active site [active] 644651000324 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 644651000325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 644651000326 active site 644651000327 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 644651000328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644651000329 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644651000330 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 644651000331 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 644651000332 putative active site [active] 644651000333 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 644651000334 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 644651000335 putative active site [active] 644651000336 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 644651000337 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 644651000338 NADP binding site [chemical binding]; other site 644651000339 homopentamer interface [polypeptide binding]; other site 644651000340 substrate binding site [chemical binding]; other site 644651000341 active site 644651000342 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 644651000343 NodB motif; other site 644651000344 putative active site [active] 644651000345 putative catalytic site [active] 644651000346 Zn binding site [ion binding]; other site 644651000347 AmiB activator; Provisional; Region: PRK11637 644651000348 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 644651000349 Peptidase family M23; Region: Peptidase_M23; pfam01551 644651000350 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644651000351 active site residue [active] 644651000352 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 644651000353 GSH binding site [chemical binding]; other site 644651000354 catalytic residues [active] 644651000355 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 644651000356 SecA binding site; other site 644651000357 Preprotein binding site; other site 644651000358 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 644651000359 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 644651000360 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 644651000361 serine acetyltransferase; Provisional; Region: cysE; PRK11132 644651000362 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 644651000363 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 644651000364 trimer interface [polypeptide binding]; other site 644651000365 active site 644651000366 substrate binding site [chemical binding]; other site 644651000367 CoA binding site [chemical binding]; other site 644651000368 putative rRNA methylase; Provisional; Region: PRK10358 644651000369 two-component sensor protein; Provisional; Region: cpxA; PRK09470 644651000370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651000371 dimerization interface [polypeptide binding]; other site 644651000372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651000373 dimer interface [polypeptide binding]; other site 644651000374 phosphorylation site [posttranslational modification] 644651000375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651000376 ATP binding site [chemical binding]; other site 644651000377 Mg2+ binding site [ion binding]; other site 644651000378 G-X-G motif; other site 644651000379 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 644651000380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651000381 active site 644651000382 phosphorylation site [posttranslational modification] 644651000383 intermolecular recognition site; other site 644651000384 dimerization interface [polypeptide binding]; other site 644651000385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651000386 DNA binding site [nucleotide binding] 644651000387 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 644651000388 dimer interface [polypeptide binding]; other site 644651000389 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 644651000390 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 644651000391 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 644651000392 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 644651000393 active site 644651000394 ADP/pyrophosphate binding site [chemical binding]; other site 644651000395 dimerization interface [polypeptide binding]; other site 644651000396 allosteric effector site; other site 644651000397 fructose-1,6-bisphosphate binding site; other site 644651000398 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 644651000399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651000400 substrate binding pocket [chemical binding]; other site 644651000401 membrane-bound complex binding site; other site 644651000402 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 644651000403 inner membrane protein YhjD; Region: TIGR00766 644651000404 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 644651000405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651000406 S-adenosylmethionine binding site [chemical binding]; other site 644651000407 Amidinotransferase; Region: Amidinotransf; cl12043 644651000408 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 644651000409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644651000410 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 644651000411 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 644651000412 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 644651000413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651000414 Walker A/P-loop; other site 644651000415 ATP binding site [chemical binding]; other site 644651000416 Q-loop/lid; other site 644651000417 ABC transporter signature motif; other site 644651000418 Walker B; other site 644651000419 D-loop; other site 644651000420 H-loop/switch region; other site 644651000421 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 644651000422 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 644651000423 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 644651000424 Fatty acid desaturase; Region: FA_desaturase; pfam00487 644651000425 putative di-iron ligands [ion binding]; other site 644651000426 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 644651000427 glutathione synthetase, prokaryotic; Region: glut_syn; TIGR01380 644651000428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644651000429 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 644651000430 malate:quinone oxidoreductase; Validated; Region: PRK05257 644651000431 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 644651000432 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 644651000433 triosephosphate isomerase; Provisional; Region: PRK14567 644651000434 substrate binding site [chemical binding]; other site 644651000435 dimer interface [polypeptide binding]; other site 644651000436 catalytic triad [active] 644651000437 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 644651000438 Predicted membrane protein [Function unknown]; Region: COG3152 644651000439 ferredoxin-NADP reductase; Provisional; Region: PRK10926 644651000440 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 644651000441 FAD binding pocket [chemical binding]; other site 644651000442 FAD binding motif [chemical binding]; other site 644651000443 phosphate binding motif [ion binding]; other site 644651000444 beta-alpha-beta structure motif; other site 644651000445 NAD binding pocket [chemical binding]; other site 644651000446 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 644651000447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651000448 putative substrate translocation pore; other site 644651000449 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 644651000450 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 644651000451 putative active site [active] 644651000452 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 644651000453 glycerol kinase; Provisional; Region: glpK; PRK00047 644651000454 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 644651000455 N- and C-terminal domain interface [polypeptide binding]; other site 644651000456 active site 644651000457 MgATP binding site [chemical binding]; other site 644651000458 catalytic site [active] 644651000459 metal binding site [ion binding]; metal-binding site 644651000460 glycerol binding site [chemical binding]; other site 644651000461 homotetramer interface [polypeptide binding]; other site 644651000462 homodimer interface [polypeptide binding]; other site 644651000463 FBP binding site [chemical binding]; other site 644651000464 protein IIAGlc interface [polypeptide binding]; other site 644651000465 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 644651000466 amphipathic channel; other site 644651000467 Asn-Pro-Ala signature motifs; other site 644651000468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 644651000469 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 644651000470 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 644651000471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651000472 Walker A motif; other site 644651000473 ATP binding site [chemical binding]; other site 644651000474 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 644651000475 Walker B motif; other site 644651000476 arginine finger; other site 644651000477 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644651000478 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 644651000479 active site 644651000480 HslU subunit interaction site [polypeptide binding]; other site 644651000481 essential cell division protein FtsN; Provisional; Region: PRK10927 644651000482 cell division protein FtsN; Provisional; Region: PRK12757 644651000483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651000484 DNA binding site [nucleotide binding] 644651000485 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 644651000486 domain linker motif; other site 644651000487 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 644651000488 dimerization interface [polypeptide binding]; other site 644651000489 ligand binding site [chemical binding]; other site 644651000490 primosome assembly protein PriA; Validated; Region: PRK05580 644651000491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651000492 ATP binding site [chemical binding]; other site 644651000493 putative Mg++ binding site [ion binding]; other site 644651000494 helicase superfamily c-terminal domain; Region: HELICc; smart00490 644651000495 ATP-binding site [chemical binding]; other site 644651000496 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 644651000497 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 644651000498 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 644651000499 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 644651000500 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644651000501 Walker A/P-loop; other site 644651000502 ATP binding site [chemical binding]; other site 644651000503 Q-loop/lid; other site 644651000504 ABC transporter signature motif; other site 644651000505 Walker B; other site 644651000506 D-loop; other site 644651000507 H-loop/switch region; other site 644651000508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 644651000509 active site 644651000510 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644651000511 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 644651000512 dimerization interface [polypeptide binding]; other site 644651000513 DNA binding site [nucleotide binding] 644651000514 corepressor binding sites; other site 644651000515 cystathionine gamma-synthase; Provisional; Region: PRK08045 644651000516 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 644651000517 homodimer interface [polypeptide binding]; other site 644651000518 substrate-cofactor binding pocket; other site 644651000519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651000520 catalytic residue [active] 644651000521 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 644651000522 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 644651000523 putative catalytic residues [active] 644651000524 putative nucleotide binding site [chemical binding]; other site 644651000525 putative aspartate binding site [chemical binding]; other site 644651000526 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644651000527 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 644651000528 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 644651000529 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 644651000530 FAD binding site [chemical binding]; other site 644651000531 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 644651000532 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 644651000533 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 644651000534 acetylornithine deacetylase; Provisional; Region: PRK05111 644651000535 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 644651000536 metal binding site [ion binding]; metal-binding site 644651000537 putative dimer interface [polypeptide binding]; other site 644651000538 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 644651000539 nucleotide binding site [chemical binding]; other site 644651000540 N-acetyl-L-glutamate binding site [chemical binding]; other site 644651000541 argininosuccinate synthase; Provisional; Region: PRK13820 644651000542 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 644651000543 ANP binding site [chemical binding]; other site 644651000544 Substrate Binding Site II [chemical binding]; other site 644651000545 Substrate Binding Site I [chemical binding]; other site 644651000546 argininosuccinate lyase; Provisional; Region: PRK04833 644651000547 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 644651000548 active sites [active] 644651000549 tetramer interface [polypeptide binding]; other site 644651000550 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 644651000551 catalytic triad [active] 644651000552 dimer interface [polypeptide binding]; other site 644651000553 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 644651000554 GSH binding site [chemical binding]; other site 644651000555 catalytic residues [active] 644651000556 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 644651000557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651000558 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 644651000559 dimerization interface [polypeptide binding]; other site 644651000560 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 644651000561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644651000562 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644651000563 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 644651000564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651000565 hypothetical protein; Provisional; Region: PRK11056 644651000566 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 644651000567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651000568 S-adenosylmethionine binding site [chemical binding]; other site 644651000569 glutamate racemase; Provisional; Region: PRK00865 644651000570 transcriptional regulator HdfR; Provisional; Region: PRK03601 644651000571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651000572 LysR substrate binding domain; Region: LysR_substrate; pfam03466 644651000573 dimerization interface [polypeptide binding]; other site 644651000574 hypothetical protein; Provisional; Region: PRK11027 644651000575 putative ATP-dependent protease; Provisional; Region: PRK09862 644651000576 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 644651000577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651000578 Walker A motif; other site 644651000579 ATP binding site [chemical binding]; other site 644651000580 Walker B motif; other site 644651000581 arginine finger; other site 644651000582 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 644651000583 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 644651000584 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644651000585 PYR/PP interface [polypeptide binding]; other site 644651000586 dimer interface [polypeptide binding]; other site 644651000587 TPP binding site [chemical binding]; other site 644651000588 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644651000589 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 644651000590 TPP-binding site [chemical binding]; other site 644651000591 dimer interface [polypeptide binding]; other site 644651000592 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 644651000593 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 644651000594 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 644651000595 homodimer interface [polypeptide binding]; other site 644651000596 substrate-cofactor binding pocket; other site 644651000597 catalytic residue [active] 644651000598 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 644651000599 threonine dehydratase; Reviewed; Region: PRK09224 644651000600 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 644651000601 tetramer interface [polypeptide binding]; other site 644651000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651000603 catalytic residue [active] 644651000604 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 644651000605 putative Ile/Val binding site [chemical binding]; other site 644651000606 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 644651000607 putative Ile/Val binding site [chemical binding]; other site 644651000608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651000609 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 644651000610 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 644651000611 putative dimerization interface [polypeptide binding]; other site 644651000612 ketol-acid reductoisomerase; Validated; Region: PRK05225 644651000613 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 644651000614 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 644651000615 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 644651000616 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 644651000617 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 644651000618 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 644651000619 Part of AAA domain; Region: AAA_19; pfam13245 644651000620 Family description; Region: UvrD_C_2; pfam13538 644651000621 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 644651000622 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 644651000623 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 644651000624 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644651000625 ATP binding site [chemical binding]; other site 644651000626 Mg++ binding site [ion binding]; other site 644651000627 motif III; other site 644651000628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651000629 nucleotide binding region [chemical binding]; other site 644651000630 ATP-binding site [chemical binding]; other site 644651000631 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644651000632 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 644651000633 catalytic residues [active] 644651000634 transcription termination factor Rho; Provisional; Region: rho; PRK09376 644651000635 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 644651000636 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 644651000637 RNA binding site [nucleotide binding]; other site 644651000638 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 644651000639 multimer interface [polypeptide binding]; other site 644651000640 Walker A motif; other site 644651000641 ATP binding site [chemical binding]; other site 644651000642 Walker B motif; other site 644651000643 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 644651000644 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 644651000645 Mg++ binding site [ion binding]; other site 644651000646 putative catalytic motif [active] 644651000647 substrate binding site [chemical binding]; other site 644651000648 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 644651000649 Chain length determinant protein; Region: Wzz; pfam02706 644651000650 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 644651000651 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 644651000652 active site 644651000653 homodimer interface [polypeptide binding]; other site 644651000654 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 644651000655 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 644651000656 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 644651000657 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 644651000658 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 644651000659 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 644651000660 NAD binding site [chemical binding]; other site 644651000661 substrate binding site [chemical binding]; other site 644651000662 homodimer interface [polypeptide binding]; other site 644651000663 active site 644651000664 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 644651000665 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 644651000666 substrate binding site; other site 644651000667 tetramer interface; other site 644651000668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644651000669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651000670 Coenzyme A binding pocket [chemical binding]; other site 644651000671 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 644651000672 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 644651000673 inhibitor-cofactor binding pocket; inhibition site 644651000674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651000675 catalytic residue [active] 644651000676 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 644651000677 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 644651000678 putative common antigen polymerase; Provisional; Region: PRK02975 644651000679 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 644651000680 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 644651000681 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 644651000682 HemY protein N-terminus; Region: HemY_N; pfam07219 644651000683 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 644651000684 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 644651000685 HemX; Region: HemX; pfam04375 644651000686 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 644651000687 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 644651000688 active site 644651000689 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 644651000690 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 644651000691 domain interfaces; other site 644651000692 active site 644651000693 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 644651000694 adenylate cyclase; Provisional; Region: cyaA; PRK09450 644651000695 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 644651000696 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 644651000697 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 644651000698 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 644651000699 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 644651000700 hypothetical protein; Provisional; Region: PRK10963 644651000701 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 644651000702 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651000703 active site 644651000704 DNA binding site [nucleotide binding] 644651000705 Int/Topo IB signature motif; other site 644651000706 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 644651000707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651000708 motif II; other site 644651000709 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 644651000710 Part of AAA domain; Region: AAA_19; pfam13245 644651000711 Family description; Region: UvrD_C_2; pfam13538 644651000712 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 644651000713 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 644651000714 Cl binding site [ion binding]; other site 644651000715 oligomer interface [polypeptide binding]; other site 644651000716 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 644651000717 CoenzymeA binding site [chemical binding]; other site 644651000718 subunit interaction site [polypeptide binding]; other site 644651000719 PHB binding site; other site 644651000720 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 644651000721 dimerization interface [polypeptide binding]; other site 644651000722 substrate binding site [chemical binding]; other site 644651000723 active site 644651000724 calcium binding site [ion binding]; other site 644651000725 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 644651000726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651000727 ATP binding site [chemical binding]; other site 644651000728 putative Mg++ binding site [ion binding]; other site 644651000729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651000730 nucleotide binding region [chemical binding]; other site 644651000731 ATP-binding site [chemical binding]; other site 644651000732 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 644651000733 Helicase and RNase D C-terminal; Region: HRDC; smart00341 644651000734 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 644651000735 lysophospholipase L2; Provisional; Region: PRK10749 644651000736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 644651000737 putative hydrolase; Provisional; Region: PRK10976 644651000738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651000739 active site 644651000740 motif I; other site 644651000741 motif II; other site 644651000742 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644651000743 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 644651000744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651000745 putative substrate translocation pore; other site 644651000746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 644651000747 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 644651000748 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 644651000749 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 644651000750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651000751 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 644651000752 putative dimerization interface [polypeptide binding]; other site 644651000753 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 644651000754 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 644651000755 THF binding site; other site 644651000756 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 644651000757 substrate binding site [chemical binding]; other site 644651000758 THF binding site; other site 644651000759 zinc-binding site [ion binding]; other site 644651000760 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 644651000761 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644651000762 uridine phosphorylase; Provisional; Region: PRK11178 644651000763 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 644651000764 RmuC family; Region: RmuC; pfam02646 644651000765 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 644651000766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651000767 S-adenosylmethionine binding site [chemical binding]; other site 644651000768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 644651000769 SCP-2 sterol transfer family; Region: SCP2; pfam02036 644651000770 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 644651000771 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 644651000772 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 644651000773 sec-independent translocase; Provisional; Region: PRK01770 644651000774 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 644651000775 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 644651000776 active site 644651000777 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 644651000778 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 644651000779 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 644651000780 homodimer interface [polypeptide binding]; other site 644651000781 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 644651000782 FMN reductase; Validated; Region: fre; PRK08051 644651000783 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 644651000784 FAD binding pocket [chemical binding]; other site 644651000785 FAD binding motif [chemical binding]; other site 644651000786 phosphate binding motif [ion binding]; other site 644651000787 beta-alpha-beta structure motif; other site 644651000788 NAD binding pocket [chemical binding]; other site 644651000789 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 644651000790 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 644651000791 dimer interface [polypeptide binding]; other site 644651000792 active site 644651000793 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 644651000794 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644651000795 substrate binding site [chemical binding]; other site 644651000796 oxyanion hole (OAH) forming residues; other site 644651000797 trimer interface [polypeptide binding]; other site 644651000798 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 644651000799 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 644651000800 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 644651000801 proline dipeptidase; Provisional; Region: PRK13607 644651000802 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 644651000803 active site 644651000804 hypothetical protein; Provisional; Region: PRK11568 644651000805 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 644651000806 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 644651000807 potassium transporter; Provisional; Region: PRK10750 644651000808 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 644651000809 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 644651000810 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 644651000811 FAD binding domain; Region: FAD_binding_4; pfam01565 644651000812 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 644651000813 Biotin operon repressor [Transcription]; Region: BirA; COG1654 644651000814 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 644651000815 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 644651000816 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 644651000817 pantothenate kinase; Provisional; Region: PRK05439 644651000818 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 644651000819 ATP-binding site [chemical binding]; other site 644651000820 CoA-binding site [chemical binding]; other site 644651000821 Mg2+-binding site [ion binding]; other site 644651000822 elongation factor Tu; Reviewed; Region: PRK00049 644651000823 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 644651000824 G1 box; other site 644651000825 GEF interaction site [polypeptide binding]; other site 644651000826 GTP/Mg2+ binding site [chemical binding]; other site 644651000827 Switch I region; other site 644651000828 G2 box; other site 644651000829 G3 box; other site 644651000830 Switch II region; other site 644651000831 G4 box; other site 644651000832 G5 box; other site 644651000833 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 644651000834 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 644651000835 Antibiotic Binding Site [chemical binding]; other site 644651000836 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 644651000837 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 644651000838 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 644651000839 putative homodimer interface [polypeptide binding]; other site 644651000840 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 644651000841 heterodimer interface [polypeptide binding]; other site 644651000842 homodimer interface [polypeptide binding]; other site 644651000843 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 644651000844 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 644651000845 23S rRNA interface [nucleotide binding]; other site 644651000846 L7/L12 interface [polypeptide binding]; other site 644651000847 putative thiostrepton binding site; other site 644651000848 L25 interface [polypeptide binding]; other site 644651000849 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 644651000850 mRNA/rRNA interface [nucleotide binding]; other site 644651000851 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 644651000852 23S rRNA interface [nucleotide binding]; other site 644651000853 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 644651000854 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 644651000855 core dimer interface [polypeptide binding]; other site 644651000856 peripheral dimer interface [polypeptide binding]; other site 644651000857 L10 interface [polypeptide binding]; other site 644651000858 L11 interface [polypeptide binding]; other site 644651000859 putative EF-Tu interaction site [polypeptide binding]; other site 644651000860 putative EF-G interaction site [polypeptide binding]; other site 644651000861 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 644651000862 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 644651000863 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 644651000864 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 644651000865 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 644651000866 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 644651000867 RPB3 interaction site [polypeptide binding]; other site 644651000868 RPB1 interaction site [polypeptide binding]; other site 644651000869 RPB11 interaction site [polypeptide binding]; other site 644651000870 RPB10 interaction site [polypeptide binding]; other site 644651000871 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 644651000872 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 644651000873 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 644651000874 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 644651000875 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 644651000876 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 644651000877 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 644651000878 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 644651000879 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 644651000880 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 644651000881 DNA binding site [nucleotide binding] 644651000882 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 644651000883 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 644651000884 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 644651000885 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 644651000886 Fimbrial protein; Region: Fimbrial; cl01416 644651000887 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 644651000888 PapC N-terminal domain; Region: PapC_N; pfam13954 644651000889 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 644651000890 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 644651000891 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 644651000892 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 644651000893 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 644651000894 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 644651000895 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 644651000896 outer membrane protease; Reviewed; Region: PRK10993 644651000897 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 644651000898 thiamine phosphate binding site [chemical binding]; other site 644651000899 active site 644651000900 pyrophosphate binding site [ion binding]; other site 644651000901 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 644651000902 ThiC-associated domain; Region: ThiC-associated; pfam13667 644651000903 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 644651000904 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 644651000905 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 644651000906 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 644651000907 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 644651000908 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 644651000909 putative NADH binding site [chemical binding]; other site 644651000910 putative active site [active] 644651000911 nudix motif; other site 644651000912 putative metal binding site [ion binding]; other site 644651000913 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 644651000914 substrate binding site [chemical binding]; other site 644651000915 active site 644651000916 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 644651000917 Active_site [active] 644651000918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 644651000919 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 644651000920 IHF dimer interface [polypeptide binding]; other site 644651000921 IHF - DNA interface [nucleotide binding]; other site 644651000922 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 644651000923 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 644651000924 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 644651000925 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 644651000926 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 644651000927 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 644651000928 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 644651000929 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 644651000930 purine monophosphate binding site [chemical binding]; other site 644651000931 dimer interface [polypeptide binding]; other site 644651000932 putative catalytic residues [active] 644651000933 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 644651000934 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 644651000935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644651000936 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644651000937 Walker A/P-loop; other site 644651000938 ATP binding site [chemical binding]; other site 644651000939 Q-loop/lid; other site 644651000940 ABC transporter signature motif; other site 644651000941 Walker B; other site 644651000942 D-loop; other site 644651000943 H-loop/switch region; other site 644651000944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651000945 dimer interface [polypeptide binding]; other site 644651000946 conserved gate region; other site 644651000947 putative PBP binding loops; other site 644651000948 ABC-ATPase subunit interface; other site 644651000949 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 644651000950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651000951 conserved gate region; other site 644651000952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651000953 putative PBP binding loops; other site 644651000954 dimer interface [polypeptide binding]; other site 644651000955 ABC-ATPase subunit interface; other site 644651000956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651000957 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 644651000958 substrate binding pocket [chemical binding]; other site 644651000959 membrane-bound complex binding site; other site 644651000960 hinge residues; other site 644651000961 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 644651000962 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 644651000963 putative acyl-acceptor binding pocket; other site 644651000964 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 644651000965 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 644651000966 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 644651000967 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 644651000968 FMN binding site [chemical binding]; other site 644651000969 active site 644651000970 catalytic residues [active] 644651000971 substrate binding site [chemical binding]; other site 644651000972 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 644651000973 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 644651000974 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 644651000975 Na binding site [ion binding]; other site 644651000976 hypothetical protein; Provisional; Region: PRK10633 644651000977 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 644651000978 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644651000979 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 644651000980 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 644651000981 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 644651000982 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 644651000983 carboxyltransferase (CT) interaction site; other site 644651000984 biotinylation site [posttranslational modification]; other site 644651000985 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 644651000986 Dehydroquinase class II; Region: DHquinase_II; pfam01220 644651000987 active site 644651000988 trimer interface [polypeptide binding]; other site 644651000989 dimer interface [polypeptide binding]; other site 644651000990 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 644651000991 TMAO/DMSO reductase; Reviewed; Region: PRK05363 644651000992 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 644651000993 Moco binding site; other site 644651000994 metal coordination site [ion binding]; other site 644651000995 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 644651000996 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 644651000997 NADP binding site [chemical binding]; other site 644651000998 dimer interface [polypeptide binding]; other site 644651000999 regulatory protein CsrD; Provisional; Region: PRK11059 644651001000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644651001001 metal binding site [ion binding]; metal-binding site 644651001002 active site 644651001003 I-site; other site 644651001004 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644651001005 rod shape-determining protein MreB; Provisional; Region: PRK13927 644651001006 MreB and similar proteins; Region: MreB_like; cd10225 644651001007 nucleotide binding site [chemical binding]; other site 644651001008 Mg binding site [ion binding]; other site 644651001009 putative protofilament interaction site [polypeptide binding]; other site 644651001010 RodZ interaction site [polypeptide binding]; other site 644651001011 rod shape-determining protein MreC; Region: mreC; TIGR00219 644651001012 rod shape-determining protein MreC; Region: MreC; pfam04085 644651001013 rod shape-determining protein MreD; Provisional; Region: PRK11060 644651001014 Maf-like protein; Region: Maf; pfam02545 644651001015 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 644651001016 active site 644651001017 dimer interface [polypeptide binding]; other site 644651001018 ribonuclease G; Provisional; Region: PRK11712 644651001019 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 644651001020 homodimer interface [polypeptide binding]; other site 644651001021 oligonucleotide binding site [chemical binding]; other site 644651001022 hypothetical protein; Provisional; Region: PRK10899 644651001023 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 644651001024 protease TldD; Provisional; Region: tldD; PRK10735 644651001025 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 644651001026 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 644651001027 transcriptional regulator; Provisional; Region: PRK10632 644651001028 efflux system membrane protein; Provisional; Region: PRK11594 644651001029 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 644651001030 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 644651001031 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651001032 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 644651001033 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 644651001034 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 644651001035 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 644651001036 arginine repressor; Provisional; Region: PRK05066 644651001037 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 644651001038 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 644651001039 malate dehydrogenase; Provisional; Region: PRK05086 644651001040 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 644651001041 NAD binding site [chemical binding]; other site 644651001042 dimerization interface [polypeptide binding]; other site 644651001043 Substrate binding site [chemical binding]; other site 644651001044 serine endoprotease; Provisional; Region: PRK10898 644651001045 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644651001046 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644651001047 protein binding site [polypeptide binding]; other site 644651001048 serine endoprotease; Provisional; Region: PRK10139 644651001049 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644651001050 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644651001051 protein binding site [polypeptide binding]; other site 644651001052 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644651001053 protein binding site [polypeptide binding]; other site 644651001054 hypothetical protein; Provisional; Region: PRK11677 644651001055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 644651001056 Predicted ATPase [General function prediction only]; Region: COG1485 644651001057 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 644651001058 23S rRNA interface [nucleotide binding]; other site 644651001059 L3 interface [polypeptide binding]; other site 644651001060 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 644651001061 stringent starvation protein A; Provisional; Region: sspA; PRK09481 644651001062 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 644651001063 C-terminal domain interface [polypeptide binding]; other site 644651001064 putative GSH binding site (G-site) [chemical binding]; other site 644651001065 dimer interface [polypeptide binding]; other site 644651001066 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 644651001067 dimer interface [polypeptide binding]; other site 644651001068 N-terminal domain interface [polypeptide binding]; other site 644651001069 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 644651001070 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 644651001071 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 644651001072 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 644651001073 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 644651001074 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 644651001075 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651001076 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 644651001077 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 644651001078 Flavodoxin; Region: Flavodoxin_1; pfam00258 644651001079 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 644651001080 FAD binding pocket [chemical binding]; other site 644651001081 FAD binding motif [chemical binding]; other site 644651001082 catalytic residues [active] 644651001083 NAD binding pocket [chemical binding]; other site 644651001084 phosphate binding motif [ion binding]; other site 644651001085 beta-alpha-beta structure motif; other site 644651001086 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 644651001087 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 644651001088 active site 644651001089 dimer interface [polypeptide binding]; other site 644651001090 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 644651001091 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 644651001092 active site 644651001093 FMN binding site [chemical binding]; other site 644651001094 substrate binding site [chemical binding]; other site 644651001095 3Fe-4S cluster binding site [ion binding]; other site 644651001096 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 644651001097 domain_subunit interface; other site 644651001098 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 644651001099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651001100 putative active site [active] 644651001101 heme pocket [chemical binding]; other site 644651001102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651001103 dimer interface [polypeptide binding]; other site 644651001104 phosphorylation site [posttranslational modification] 644651001105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651001106 ATP binding site [chemical binding]; other site 644651001107 Mg2+ binding site [ion binding]; other site 644651001108 G-X-G motif; other site 644651001109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651001110 active site 644651001111 phosphorylation site [posttranslational modification] 644651001112 intermolecular recognition site; other site 644651001113 dimerization interface [polypeptide binding]; other site 644651001114 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 644651001115 putative binding surface; other site 644651001116 active site 644651001117 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 644651001118 Transglycosylase; Region: Transgly; cl17702 644651001119 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 644651001120 dimerization domain swap beta strand [polypeptide binding]; other site 644651001121 regulatory protein interface [polypeptide binding]; other site 644651001122 active site 644651001123 regulatory phosphorylation site [posttranslational modification]; other site 644651001124 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 644651001125 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644651001126 active site 644651001127 phosphorylation site [posttranslational modification] 644651001128 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 644651001129 30S subunit binding site; other site 644651001130 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 644651001131 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 644651001132 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 644651001133 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 644651001134 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 644651001135 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 644651001136 Walker A/P-loop; other site 644651001137 ATP binding site [chemical binding]; other site 644651001138 Q-loop/lid; other site 644651001139 ABC transporter signature motif; other site 644651001140 Walker B; other site 644651001141 D-loop; other site 644651001142 H-loop/switch region; other site 644651001143 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 644651001144 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 644651001145 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 644651001146 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 644651001147 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 644651001148 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 644651001149 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 644651001150 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 644651001151 putative active site [active] 644651001152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 644651001153 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 644651001154 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 644651001155 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 644651001156 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 644651001157 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 644651001158 Walker A/P-loop; other site 644651001159 ATP binding site [chemical binding]; other site 644651001160 Q-loop/lid; other site 644651001161 ABC transporter signature motif; other site 644651001162 Walker B; other site 644651001163 D-loop; other site 644651001164 H-loop/switch region; other site 644651001165 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 644651001166 conserved hypothetical integral membrane protein; Region: TIGR00056 644651001167 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 644651001168 mce related protein; Region: MCE; pfam02470 644651001169 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 644651001170 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 644651001171 anti sigma factor interaction site; other site 644651001172 regulatory phosphorylation site [posttranslational modification]; other site 644651001173 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 644651001174 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 644651001175 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 644651001176 hinge; other site 644651001177 active site 644651001178 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 644651001179 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644651001180 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644651001181 substrate binding pocket [chemical binding]; other site 644651001182 chain length determination region; other site 644651001183 substrate-Mg2+ binding site; other site 644651001184 catalytic residues [active] 644651001185 aspartate-rich region 1; other site 644651001186 active site lid residues [active] 644651001187 aspartate-rich region 2; other site 644651001188 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 644651001189 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 644651001190 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 644651001191 Annotation is too short ref|YP_005801111| 644651001192 GTPase CgtA; Reviewed; Region: obgE; PRK12298 644651001193 GTP1/OBG; Region: GTP1_OBG; pfam01018 644651001194 Obg GTPase; Region: Obg; cd01898 644651001195 G1 box; other site 644651001196 GTP/Mg2+ binding site [chemical binding]; other site 644651001197 Switch I region; other site 644651001198 G2 box; other site 644651001199 G3 box; other site 644651001200 Switch II region; other site 644651001201 G4 box; other site 644651001202 G5 box; other site 644651001203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651001204 active site 644651001205 dimerization interface [polypeptide binding]; other site 644651001206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 644651001207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651001208 active site 644651001209 phosphorylation site [posttranslational modification] 644651001210 intermolecular recognition site; other site 644651001211 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 644651001212 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 644651001213 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 644651001214 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 644651001215 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 644651001216 RNA-binding protein YhbY; Provisional; Region: PRK10343 644651001217 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 644651001218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651001219 S-adenosylmethionine binding site [chemical binding]; other site 644651001220 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 644651001221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651001222 Walker A motif; other site 644651001223 ATP binding site [chemical binding]; other site 644651001224 Walker B motif; other site 644651001225 arginine finger; other site 644651001226 Peptidase family M41; Region: Peptidase_M41; pfam01434 644651001227 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 644651001228 dihydropteroate synthase; Region: DHPS; TIGR01496 644651001229 substrate binding pocket [chemical binding]; other site 644651001230 dimer interface [polypeptide binding]; other site 644651001231 inhibitor binding site; inhibition site 644651001232 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 644651001233 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 644651001234 active site 644651001235 substrate binding site [chemical binding]; other site 644651001236 metal binding site [ion binding]; metal-binding site 644651001237 Preprotein translocase SecG subunit; Region: SecG; pfam03840 644651001238 ribosome maturation protein RimP; Reviewed; Region: PRK00092 644651001239 Sm and related proteins; Region: Sm_like; cl00259 644651001240 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 644651001241 putative oligomer interface [polypeptide binding]; other site 644651001242 putative RNA binding site [nucleotide binding]; other site 644651001243 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 644651001244 NusA N-terminal domain; Region: NusA_N; pfam08529 644651001245 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 644651001246 RNA binding site [nucleotide binding]; other site 644651001247 homodimer interface [polypeptide binding]; other site 644651001248 NusA-like KH domain; Region: KH_5; pfam13184 644651001249 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 644651001250 G-X-X-G motif; other site 644651001251 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 644651001252 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 644651001253 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 644651001254 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 644651001255 translation initiation factor IF-2; Region: IF-2; TIGR00487 644651001256 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 644651001257 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 644651001258 G1 box; other site 644651001259 putative GEF interaction site [polypeptide binding]; other site 644651001260 GTP/Mg2+ binding site [chemical binding]; other site 644651001261 Switch I region; other site 644651001262 G2 box; other site 644651001263 G3 box; other site 644651001264 Switch II region; other site 644651001265 G4 box; other site 644651001266 G5 box; other site 644651001267 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 644651001268 Translation-initiation factor 2; Region: IF-2; pfam11987 644651001269 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 644651001270 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 644651001271 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 644651001272 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 644651001273 RNA binding site [nucleotide binding]; other site 644651001274 active site 644651001275 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 644651001276 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 644651001277 16S/18S rRNA binding site [nucleotide binding]; other site 644651001278 S13e-L30e interaction site [polypeptide binding]; other site 644651001279 25S rRNA binding site [nucleotide binding]; other site 644651001280 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 644651001281 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 644651001282 RNase E interface [polypeptide binding]; other site 644651001283 trimer interface [polypeptide binding]; other site 644651001284 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 644651001285 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 644651001286 RNase E interface [polypeptide binding]; other site 644651001287 trimer interface [polypeptide binding]; other site 644651001288 active site 644651001289 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 644651001290 RNA binding site [nucleotide binding]; other site 644651001291 domain interface; other site 644651001292 lipoprotein NlpI; Provisional; Region: PRK11189 644651001293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644651001294 binding surface 644651001295 TPR motif; other site 644651001296 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 644651001297 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644651001298 ATP binding site [chemical binding]; other site 644651001299 Mg++ binding site [ion binding]; other site 644651001300 motif III; other site 644651001301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651001302 nucleotide binding region [chemical binding]; other site 644651001303 ATP-binding site [chemical binding]; other site 644651001304 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 644651001305 putative RNA binding site [nucleotide binding]; other site 644651001306 hypothetical protein; Provisional; Region: PRK10508 644651001307 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 644651001308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 644651001309 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 644651001310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651001311 Coenzyme A binding pocket [chemical binding]; other site 644651001312 Predicted membrane protein [Function unknown]; Region: COG3766 644651001313 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 644651001314 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 644651001315 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 644651001316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651001317 FeS/SAM binding site; other site 644651001318 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 644651001319 ATP cone domain; Region: ATP-cone; pfam03477 644651001320 Class III ribonucleotide reductase; Region: RNR_III; cd01675 644651001321 effector binding site; other site 644651001322 active site 644651001323 Zn binding site [ion binding]; other site 644651001324 glycine loop; other site 644651001325 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 644651001326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651001327 ATP binding site [chemical binding]; other site 644651001328 putative Mg++ binding site [ion binding]; other site 644651001329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651001330 nucleotide binding region [chemical binding]; other site 644651001331 ATP-binding site [chemical binding]; other site 644651001332 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 644651001333 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 644651001334 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 644651001335 active site 644651001336 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 644651001337 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 644651001338 homotrimer interaction site [polypeptide binding]; other site 644651001339 putative active site [active] 644651001340 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 644651001341 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 644651001342 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 644651001343 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 644651001344 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 644651001345 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 644651001346 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 644651001347 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 644651001348 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 644651001349 RNase E inhibitor protein; Provisional; Region: PRK11191 644651001350 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 644651001351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651001352 Coenzyme A binding pocket [chemical binding]; other site 644651001353 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 644651001354 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 644651001355 HIGH motif; other site 644651001356 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644651001357 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 644651001358 active site 644651001359 KMSKS motif; other site 644651001360 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 644651001361 tRNA binding surface [nucleotide binding]; other site 644651001362 anticodon binding site; other site 644651001363 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 644651001364 DNA polymerase III subunit chi; Validated; Region: PRK05728 644651001365 multifunctional aminopeptidase A; Provisional; Region: PRK00913 644651001366 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 644651001367 interface (dimer of trimers) [polypeptide binding]; other site 644651001368 Substrate-binding/catalytic site; other site 644651001369 Zn-binding sites [ion binding]; other site 644651001370 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 644651001371 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 644651001372 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 644651001373 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 644651001374 Predicted membrane protein [Function unknown]; Region: COG2733 644651001375 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 644651001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 644651001377 Walker A motif; other site 644651001378 ATP binding site [chemical binding]; other site 644651001379 hypothetical protein; Provisional; Region: PRK11667 644651001380 Winged helix-turn helix; Region: HTH_29; pfam13551 644651001381 Helix-turn-helix domain; Region: HTH_28; pfam13518 644651001382 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644651001383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651001384 Coenzyme A binding pocket [chemical binding]; other site 644651001385 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 644651001386 hypothetical protein; Provisional; Region: PRK07206 644651001387 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 644651001388 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 644651001389 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 644651001390 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 644651001391 FAD binding domain; Region: FAD_binding_4; pfam01565 644651001392 Berberine and berberine like; Region: BBE; pfam08031 644651001393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651001394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644651001395 putative substrate translocation pore; other site 644651001396 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 644651001397 active site 644651001398 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 644651001399 dimer interface [polypeptide binding]; other site 644651001400 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 644651001401 Ligand Binding Site [chemical binding]; other site 644651001402 Molecular Tunnel; other site 644651001403 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 644651001404 classical (c) SDRs; Region: SDR_c; cd05233 644651001405 NAD(P) binding site [chemical binding]; other site 644651001406 active site 644651001407 Cupin domain; Region: Cupin_2; pfam07883 644651001408 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 644651001409 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644651001410 active site 644651001411 nucleotide binding site [chemical binding]; other site 644651001412 HIGH motif; other site 644651001413 KMSKS motif; other site 644651001414 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 644651001415 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 644651001416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651001417 active site 644651001418 motif I; other site 644651001419 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 644651001420 active site 644651001421 catalytic residues [active] 644651001422 metal binding site [ion binding]; metal-binding site 644651001423 Domain of unknown function (DUF718); Region: DUF718; cl01281 644651001424 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 644651001425 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 644651001426 inhibitor site; inhibition site 644651001427 active site 644651001428 dimer interface [polypeptide binding]; other site 644651001429 catalytic residue [active] 644651001430 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 644651001431 hydroxyglutarate oxidase; Provisional; Region: PRK11728 644651001432 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 644651001433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644651001434 Part of AAA domain; Region: AAA_19; pfam13245 644651001435 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 644651001436 AAA domain; Region: AAA_12; pfam13087 644651001437 hypothetical protein; Provisional; Region: PRK10396 644651001438 yecA family protein; Region: ygfB_yecA; TIGR02292 644651001439 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 644651001440 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 644651001441 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651001442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651001443 non-specific DNA binding site [nucleotide binding]; other site 644651001444 salt bridge; other site 644651001445 sequence-specific DNA binding site [nucleotide binding]; other site 644651001446 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 644651001447 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 644651001448 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644651001449 phosphoglycerol transferase I; Provisional; Region: PRK03776 644651001450 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 644651001451 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 644651001452 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 644651001453 active site 644651001454 SUMO-1 interface [polypeptide binding]; other site 644651001455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 644651001456 dimerization interface [polypeptide binding]; other site 644651001457 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 644651001458 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651001459 dimer interface [polypeptide binding]; other site 644651001460 putative CheW interface [polypeptide binding]; other site 644651001461 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 644651001462 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 644651001463 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 644651001464 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 644651001465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644651001466 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644651001467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644651001468 DNA binding residues [nucleotide binding] 644651001469 DNA primase; Validated; Region: dnaG; PRK05667 644651001470 CHC2 zinc finger; Region: zf-CHC2; pfam01807 644651001471 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651001472 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 644651001473 active site 644651001474 metal binding site [ion binding]; metal-binding site 644651001475 interdomain interaction site; other site 644651001476 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 644651001477 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 644651001478 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 644651001479 UGMP family protein; Validated; Region: PRK09604 644651001480 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 644651001481 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 644651001482 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 644651001483 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 644651001484 homooctamer interface [polypeptide binding]; other site 644651001485 active site 644651001486 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 644651001487 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 644651001488 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 644651001489 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 644651001490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644651001491 Zn2+ binding site [ion binding]; other site 644651001492 Mg2+ binding site [ion binding]; other site 644651001493 SH3 domain-containing protein; Provisional; Region: PRK10884 644651001494 Bacterial SH3 domain homologues; Region: SH3b; smart00287 644651001495 Uncharacterized conserved protein [Function unknown]; Region: COG3025 644651001496 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 644651001497 putative active site [active] 644651001498 putative metal binding residues [ion binding]; other site 644651001499 signature motif; other site 644651001500 putative triphosphate binding site [ion binding]; other site 644651001501 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 644651001502 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 644651001503 metal binding triad; other site 644651001504 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 644651001505 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 644651001506 metal binding triad; other site 644651001507 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 644651001508 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 644651001509 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 644651001510 putative ribose interaction site [chemical binding]; other site 644651001511 putative ADP binding site [chemical binding]; other site 644651001512 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 644651001513 active site 644651001514 nucleotide binding site [chemical binding]; other site 644651001515 HIGH motif; other site 644651001516 KMSKS motif; other site 644651001517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 644651001518 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 644651001519 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 644651001520 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 644651001521 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 644651001522 putative active site [active] 644651001523 metal binding site [ion binding]; metal-binding site 644651001524 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 644651001525 hypothetical protein; Provisional; Region: PRK11653 644651001526 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 644651001527 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 644651001528 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 644651001529 dimer interface [polypeptide binding]; other site 644651001530 ADP-ribose binding site [chemical binding]; other site 644651001531 active site 644651001532 nudix motif; other site 644651001533 metal binding site [ion binding]; metal-binding site 644651001534 putative dehydrogenase; Provisional; Region: PRK11039 644651001535 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 644651001536 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644651001537 active site 644651001538 metal binding site [ion binding]; metal-binding site 644651001539 hexamer interface [polypeptide binding]; other site 644651001540 esterase YqiA; Provisional; Region: PRK11071 644651001541 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644651001542 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 644651001543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651001544 ATP binding site [chemical binding]; other site 644651001545 Mg2+ binding site [ion binding]; other site 644651001546 G-X-G motif; other site 644651001547 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 644651001548 anchoring element; other site 644651001549 dimer interface [polypeptide binding]; other site 644651001550 ATP binding site [chemical binding]; other site 644651001551 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 644651001552 active site 644651001553 metal binding site [ion binding]; metal-binding site 644651001554 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 644651001555 Uncharacterized conserved protein [Function unknown]; Region: COG1359 644651001556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651001557 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644651001558 substrate binding pocket [chemical binding]; other site 644651001559 membrane-bound complex binding site; other site 644651001560 hinge residues; other site 644651001561 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 644651001562 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 644651001563 CAP-like domain; other site 644651001564 active site 644651001565 primary dimer interface [polypeptide binding]; other site 644651001566 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 644651001567 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 644651001568 putative acyl-acceptor binding pocket; other site 644651001569 FtsI repressor; Provisional; Region: PRK10883 644651001570 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 644651001571 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 644651001572 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644651001573 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644651001574 active site 644651001575 catalytic tetrad [active] 644651001576 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 644651001577 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 644651001578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651001579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651001580 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 644651001581 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644651001582 inhibitor-cofactor binding pocket; inhibition site 644651001583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651001584 catalytic residue [active] 644651001585 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 644651001586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651001587 catalytic residue [active] 644651001588 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 644651001589 Homeodomain-like domain; Region: HTH_23; pfam13384 644651001590 Winged helix-turn helix; Region: HTH_29; pfam13551 644651001591 Homeodomain-like domain; Region: HTH_32; pfam13565 644651001592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651001593 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651001594 potential frameshift: common BLAST hit: gi|259907138|ref|YP_002647494.1| transposase 644651001595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651001596 MULE transposase domain; Region: MULE; pfam10551 644651001597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651001598 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 644651001599 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 644651001600 active site 644651001601 Int/Topo IB signature motif; other site 644651001602 catalytic residues [active] 644651001603 DNA binding site [nucleotide binding] 644651001604 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 644651001605 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 644651001606 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 644651001607 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 644651001608 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 644651001609 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 644651001610 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 644651001611 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 644651001612 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 644651001613 active site 644651001614 catalytic residues [active] 644651001615 DNA binding site [nucleotide binding] 644651001616 Int/Topo IB signature motif; other site 644651001617 putative transcriptional regulator; Provisional; Region: PRK11640 644651001618 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 644651001619 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 644651001620 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 644651001621 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 644651001622 DsbD alpha interface [polypeptide binding]; other site 644651001623 catalytic residues [active] 644651001624 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 644651001625 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 644651001626 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 644651001627 Aspartase; Region: Aspartase; cd01357 644651001628 active sites [active] 644651001629 tetramer interface [polypeptide binding]; other site 644651001630 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 644651001631 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 644651001632 oligomerisation interface [polypeptide binding]; other site 644651001633 mobile loop; other site 644651001634 roof hairpin; other site 644651001635 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 644651001636 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 644651001637 ring oligomerisation interface [polypeptide binding]; other site 644651001638 ATP/Mg binding site [chemical binding]; other site 644651001639 stacking interactions; other site 644651001640 hinge regions; other site 644651001641 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 644651001642 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 644651001643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651001644 FeS/SAM binding site; other site 644651001645 elongation factor P; Validated; Region: PRK00529 644651001646 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 644651001647 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 644651001648 RNA binding site [nucleotide binding]; other site 644651001649 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 644651001650 RNA binding site [nucleotide binding]; other site 644651001651 Predicted small secreted protein [Function unknown]; Region: COG5510 644651001652 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 644651001653 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 644651001654 poxB regulator PoxA; Provisional; Region: PRK09350 644651001655 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644651001656 motif 1; other site 644651001657 dimer interface [polypeptide binding]; other site 644651001658 active site 644651001659 motif 2; other site 644651001660 motif 3; other site 644651001661 putative mechanosensitive channel protein; Provisional; Region: PRK10929 644651001662 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 644651001663 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644651001664 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 644651001665 GTPase RsgA; Reviewed; Region: PRK12288 644651001666 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644651001667 RNA binding site [nucleotide binding]; other site 644651001668 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 644651001669 GTPase/Zn-binding domain interface [polypeptide binding]; other site 644651001670 GTP/Mg2+ binding site [chemical binding]; other site 644651001671 G4 box; other site 644651001672 G5 box; other site 644651001673 G1 box; other site 644651001674 Switch I region; other site 644651001675 G2 box; other site 644651001676 G3 box; other site 644651001677 Switch II region; other site 644651001678 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 644651001679 catalytic site [active] 644651001680 putative active site [active] 644651001681 putative substrate binding site [chemical binding]; other site 644651001682 dimer interface [polypeptide binding]; other site 644651001683 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 644651001684 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 644651001685 putative carbohydrate kinase; Provisional; Region: PRK10565 644651001686 Uncharacterized conserved protein [Function unknown]; Region: COG0062 644651001687 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 644651001688 putative substrate binding site [chemical binding]; other site 644651001689 putative ATP binding site [chemical binding]; other site 644651001690 ADP-binding protein; Provisional; Region: PRK10646 644651001691 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 644651001692 AMIN domain; Region: AMIN; pfam11741 644651001693 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644651001694 active site 644651001695 metal binding site [ion binding]; metal-binding site 644651001696 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644651001697 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 644651001698 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644651001699 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 644651001700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651001701 ATP binding site [chemical binding]; other site 644651001702 Mg2+ binding site [ion binding]; other site 644651001703 G-X-G motif; other site 644651001704 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 644651001705 ATP binding site [chemical binding]; other site 644651001706 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 644651001707 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 644651001708 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 644651001709 bacterial Hfq-like; Region: Hfq; cd01716 644651001710 hexamer interface [polypeptide binding]; other site 644651001711 Sm1 motif; other site 644651001712 RNA binding site [nucleotide binding]; other site 644651001713 Sm2 motif; other site 644651001714 GTPase HflX; Provisional; Region: PRK11058 644651001715 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 644651001716 HflX GTPase family; Region: HflX; cd01878 644651001717 G1 box; other site 644651001718 GTP/Mg2+ binding site [chemical binding]; other site 644651001719 Switch I region; other site 644651001720 G2 box; other site 644651001721 G3 box; other site 644651001722 Switch II region; other site 644651001723 G4 box; other site 644651001724 G5 box; other site 644651001725 FtsH protease regulator HflK; Provisional; Region: PRK10930 644651001726 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 644651001727 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 644651001728 FtsH protease regulator HflC; Provisional; Region: PRK11029 644651001729 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 644651001730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 644651001731 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 644651001732 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 644651001733 GDP-binding site [chemical binding]; other site 644651001734 ACT binding site; other site 644651001735 IMP binding site; other site 644651001736 Transcriptional regulator; Region: Rrf2; cl17282 644651001737 Transcriptional regulator; Region: Rrf2; cl17282 644651001738 exoribonuclease R; Provisional; Region: PRK11642 644651001739 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 644651001740 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 644651001741 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644651001742 RNB domain; Region: RNB; pfam00773 644651001743 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 644651001744 RNA binding site [nucleotide binding]; other site 644651001745 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 644651001746 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 644651001747 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644651001748 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 644651001749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651001750 dimerization interface [polypeptide binding]; other site 644651001751 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 644651001752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651001753 dimer interface [polypeptide binding]; other site 644651001754 putative CheW interface [polypeptide binding]; other site 644651001755 esterase; Provisional; Region: PRK10566 644651001756 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644651001757 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 644651001758 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644651001759 dimer interface [polypeptide binding]; other site 644651001760 ssDNA binding site [nucleotide binding]; other site 644651001761 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644651001762 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 644651001763 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 644651001764 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 644651001765 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 644651001766 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 644651001767 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 644651001768 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 644651001769 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 644651001770 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644651001771 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 644651001772 putative active site [active] 644651001773 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 644651001774 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 644651001775 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 644651001776 active site 644651001777 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 644651001778 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 644651001779 Domain of unknown function DUF21; Region: DUF21; pfam01595 644651001780 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644651001781 Transporter associated domain; Region: CorC_HlyC; smart01091 644651001782 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 644651001783 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 644651001784 Surface antigen; Region: Bac_surface_Ag; pfam01103 644651001785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 644651001786 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 644651001787 Family of unknown function (DUF490); Region: DUF490; pfam04357 644651001788 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 644651001789 putative active site pocket [active] 644651001790 dimerization interface [polypeptide binding]; other site 644651001791 putative catalytic residue [active] 644651001792 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 644651001793 dimer interface [polypeptide binding]; other site 644651001794 substrate binding site [chemical binding]; other site 644651001795 metal binding sites [ion binding]; metal-binding site 644651001796 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 644651001797 dimer interface [polypeptide binding]; other site 644651001798 ligand binding site [chemical binding]; other site 644651001799 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 644651001800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651001801 dimerization interface [polypeptide binding]; other site 644651001802 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651001803 dimer interface [polypeptide binding]; other site 644651001804 putative CheW interface [polypeptide binding]; other site 644651001805 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644651001806 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 644651001807 aromatic chitin/cellulose binding site residues [chemical binding]; other site 644651001808 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 644651001809 AMP binding site [chemical binding]; other site 644651001810 metal binding site [ion binding]; metal-binding site 644651001811 active site 644651001812 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 644651001813 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644651001814 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644651001815 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644651001816 hypothetical protein; Provisional; Region: PRK05255 644651001817 peptidase PmbA; Provisional; Region: PRK11040 644651001818 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 644651001819 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 644651001820 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 644651001821 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 644651001822 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 644651001823 dihydroorotase; Provisional; Region: PRK09237 644651001824 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644651001825 active site 644651001826 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 644651001827 catalytic residue [active] 644651001828 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 644651001829 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 644651001830 HTH domain; Region: HTH_11; pfam08279 644651001831 Mga helix-turn-helix domain; Region: Mga; pfam05043 644651001832 PRD domain; Region: PRD; pfam00874 644651001833 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 644651001834 active site 644651001835 P-loop; other site 644651001836 phosphorylation site [posttranslational modification] 644651001837 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644651001838 active site 644651001839 phosphorylation site [posttranslational modification] 644651001840 outer membrane lipoprotein; Provisional; Region: PRK11023 644651001841 BON domain; Region: BON; pfam04972 644651001842 BON domain; Region: BON; pfam04972 644651001843 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 644651001844 dimer interface [polypeptide binding]; other site 644651001845 active site 644651001846 hypothetical protein; Reviewed; Region: PRK12497 644651001847 LppC putative lipoprotein; Region: LppC; pfam04348 644651001848 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 644651001849 putative ligand binding site [chemical binding]; other site 644651001850 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 644651001851 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 644651001852 putative SAM binding site [chemical binding]; other site 644651001853 putative homodimer interface [polypeptide binding]; other site 644651001854 Pirin-related protein [General function prediction only]; Region: COG1741 644651001855 Pirin; Region: Pirin; pfam02678 644651001856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651001857 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 644651001858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644651001859 dimerization interface [polypeptide binding]; other site 644651001860 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 644651001861 Predicted membrane protein [Function unknown]; Region: COG2259 644651001862 YqjK-like protein; Region: YqjK; pfam13997 644651001863 Predicted membrane protein [Function unknown]; Region: COG5393 644651001864 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 644651001865 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 644651001866 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 644651001867 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 644651001868 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644651001869 serine/threonine transporter SstT; Provisional; Region: PRK13628 644651001870 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 644651001871 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 644651001872 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 644651001873 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 644651001874 Cl- selectivity filter; other site 644651001875 Cl- binding residues [ion binding]; other site 644651001876 pore gating glutamate residue; other site 644651001877 dimer interface [polypeptide binding]; other site 644651001878 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 644651001879 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 644651001880 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 644651001881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651001882 S-adenosylmethionine binding site [chemical binding]; other site 644651001883 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 644651001884 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 644651001885 active site 644651001886 FMN binding site [chemical binding]; other site 644651001887 2,4-decadienoyl-CoA binding site; other site 644651001888 catalytic residue [active] 644651001889 4Fe-4S cluster binding site [ion binding]; other site 644651001890 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 644651001891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644651001892 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 644651001893 active site clefts [active] 644651001894 zinc binding site [ion binding]; other site 644651001895 dimer interface [polypeptide binding]; other site 644651001896 high affinity sulphate transporter 1; Region: sulP; TIGR00815 644651001897 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 644651001898 Sulfate transporter family; Region: Sulfate_transp; pfam00916 644651001899 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 644651001900 active site 644651001901 dimer interface [polypeptide binding]; other site 644651001902 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 644651001903 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 644651001904 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 644651001905 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 644651001906 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 644651001907 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 644651001908 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 644651001909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651001910 FeS/SAM binding site; other site 644651001911 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 644651001912 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 644651001913 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 644651001914 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644651001915 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 644651001916 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 644651001917 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 644651001918 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 644651001919 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 644651001920 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 644651001921 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 644651001922 putative NAD(P) binding site [chemical binding]; other site 644651001923 active site 644651001924 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 644651001925 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 644651001926 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 644651001927 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644651001928 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 644651001929 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 644651001930 putative active site [active] 644651001931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 644651001932 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 644651001933 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 644651001934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651001935 ATP binding site [chemical binding]; other site 644651001936 putative Mg++ binding site [ion binding]; other site 644651001937 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 644651001938 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 644651001939 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 644651001940 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 644651001941 HsdM N-terminal domain; Region: HsdM_N; pfam12161 644651001942 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 644651001943 Methyltransferase domain; Region: Methyltransf_26; pfam13659 644651001944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 644651001945 ligand binding site [chemical binding]; other site 644651001946 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 644651001947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651001948 ATP binding site [chemical binding]; other site 644651001949 putative Mg++ binding site [ion binding]; other site 644651001950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651001951 nucleotide binding region [chemical binding]; other site 644651001952 ATP-binding site [chemical binding]; other site 644651001953 Predicted transcriptional regulator [Transcription]; Region: COG2932 644651001954 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 644651001955 putative transposase OrfB; Reviewed; Region: PHA02517 644651001956 HTH-like domain; Region: HTH_21; pfam13276 644651001957 Integrase core domain; Region: rve; pfam00665 644651001958 Integrase core domain; Region: rve_3; pfam13683 644651001959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651001960 Transposase; Region: HTH_Tnp_1; pfam01527 644651001961 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 644651001962 catalytic residues [active] 644651001963 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 644651001964 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 644651001965 PLD-like domain; Region: PLDc_2; pfam13091 644651001966 putative active site [active] 644651001967 catalytic site [active] 644651001968 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 644651001969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651001970 metabolite-proton symporter; Region: 2A0106; TIGR00883 644651001971 putative substrate translocation pore; other site 644651001972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644651001973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651001974 DNA binding site [nucleotide binding] 644651001975 domain linker motif; other site 644651001976 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644651001977 dimerization interface [polypeptide binding]; other site 644651001978 ligand binding site [chemical binding]; other site 644651001979 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 644651001980 active site 644651001981 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 644651001982 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 644651001983 putative sialic acid transporter; Region: 2A0112; TIGR00891 644651001984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651001985 putative substrate translocation pore; other site 644651001986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 644651001987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644651001988 metal binding site [ion binding]; metal-binding site 644651001989 active site 644651001990 I-site; other site 644651001991 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 644651001992 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 644651001993 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 644651001994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651001995 S-adenosylmethionine binding site [chemical binding]; other site 644651001996 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 644651001997 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644651001998 dUMP phosphatase; Provisional; Region: PRK09449 644651001999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651002000 motif II; other site 644651002001 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 644651002002 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 644651002003 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 644651002004 hypothetical protein; Provisional; Region: PRK07033 644651002005 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 644651002006 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 644651002007 ligand binding site [chemical binding]; other site 644651002008 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 644651002009 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 644651002010 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 644651002011 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 644651002012 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 644651002013 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 644651002014 Protein of unknown function (DUF770); Region: DUF770; pfam05591 644651002015 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 644651002016 Protein of unknown function (DUF877); Region: DUF877; pfam05943 644651002017 Protein of unknown function (DUF796); Region: DUF796; pfam05638 644651002018 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 644651002019 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 644651002020 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 644651002021 phosphopeptide binding site; other site 644651002022 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 644651002023 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 644651002024 active site 644651002025 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 644651002026 ImpE protein; Region: ImpE; pfam07024 644651002027 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 644651002028 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 644651002029 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 644651002030 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 644651002031 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 644651002032 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 644651002033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651002034 Walker A motif; other site 644651002035 ATP binding site [chemical binding]; other site 644651002036 Walker B motif; other site 644651002037 arginine finger; other site 644651002038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651002039 Walker A motif; other site 644651002040 ATP binding site [chemical binding]; other site 644651002041 Walker B motif; other site 644651002042 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644651002043 Protein kinase domain; Region: Pkinase; pfam00069 644651002044 Catalytic domain of Protein Kinases; Region: PKc; cd00180 644651002045 active site 644651002046 ATP binding site [chemical binding]; other site 644651002047 substrate binding site [chemical binding]; other site 644651002048 activation loop (A-loop); other site 644651002049 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 644651002050 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 644651002051 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 644651002052 PAAR motif; Region: PAAR_motif; pfam05488 644651002053 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 644651002054 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 644651002055 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 644651002056 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 644651002057 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 644651002058 Homeodomain-like domain; Region: HTH_23; pfam13384 644651002059 Winged helix-turn helix; Region: HTH_29; pfam13551 644651002060 Homeodomain-like domain; Region: HTH_32; pfam13565 644651002061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651002062 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651002063 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 644651002064 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 644651002065 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 644651002066 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 644651002067 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 644651002068 G1 box; other site 644651002069 putative GEF interaction site [polypeptide binding]; other site 644651002070 GTP/Mg2+ binding site [chemical binding]; other site 644651002071 Switch I region; other site 644651002072 G2 box; other site 644651002073 G3 box; other site 644651002074 Switch II region; other site 644651002075 G4 box; other site 644651002076 G5 box; other site 644651002077 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 644651002078 periplasmic protein; Provisional; Region: PRK10568 644651002079 BON domain; Region: BON; pfam04972 644651002080 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 644651002081 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 644651002082 active site 644651002083 nucleophile elbow; other site 644651002084 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 644651002085 active site 644651002086 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 644651002087 intersubunit interface [polypeptide binding]; other site 644651002088 active site 644651002089 catalytic residue [active] 644651002090 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 644651002091 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 644651002092 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 644651002093 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 644651002094 phosphopentomutase; Provisional; Region: PRK05362 644651002095 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 644651002096 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 644651002097 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 644651002098 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 644651002099 HipA-like C-terminal domain; Region: HipA_C; pfam07804 644651002100 hypothetical protein; Provisional; Region: PRK11246 644651002101 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 644651002102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651002103 motif II; other site 644651002104 DNA repair protein RadA; Region: sms; TIGR00416 644651002105 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 644651002106 Walker A motif/ATP binding site; other site 644651002107 ATP binding site [chemical binding]; other site 644651002108 Walker B motif; other site 644651002109 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 644651002110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651002111 non-specific DNA binding site [nucleotide binding]; other site 644651002112 salt bridge; other site 644651002113 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 644651002114 sequence-specific DNA binding site [nucleotide binding]; other site 644651002115 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 644651002116 active site 644651002117 (T/H)XGH motif; other site 644651002118 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 644651002119 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 644651002120 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 644651002121 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 644651002122 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 644651002123 putative NAD(P) binding site [chemical binding]; other site 644651002124 dimer interface [polypeptide binding]; other site 644651002125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651002126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651002127 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 644651002128 putative effector binding pocket; other site 644651002129 dimerization interface [polypeptide binding]; other site 644651002130 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 644651002131 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651002132 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651002133 ABC transporter; Region: ABC_tran_2; pfam12848 644651002134 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651002135 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 644651002136 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644651002137 P-loop; other site 644651002138 Magnesium ion binding site [ion binding]; other site 644651002139 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 644651002140 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644651002141 lytic murein transglycosylase; Provisional; Region: PRK11619 644651002142 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644651002143 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644651002144 catalytic residue [active] 644651002145 Trp operon repressor; Provisional; Region: PRK01381 644651002146 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 644651002147 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644651002148 catalytic core [active] 644651002149 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 644651002150 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 644651002151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651002152 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 644651002153 hypothetical protein; Provisional; Region: PRK10756 644651002154 CreA protein; Region: CreA; pfam05981 644651002155 two-component response regulator; Provisional; Region: PRK11173 644651002156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651002157 active site 644651002158 phosphorylation site [posttranslational modification] 644651002159 intermolecular recognition site; other site 644651002160 dimerization interface [polypeptide binding]; other site 644651002161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651002162 DNA binding site [nucleotide binding] 644651002163 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 644651002164 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 644651002165 putative catalytic residues [active] 644651002166 putative nucleotide binding site [chemical binding]; other site 644651002167 putative aspartate binding site [chemical binding]; other site 644651002168 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 644651002169 dimer interface [polypeptide binding]; other site 644651002170 putative threonine allosteric regulatory site; other site 644651002171 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 644651002172 putative threonine allosteric regulatory site; other site 644651002173 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 644651002174 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 644651002175 homoserine kinase; Provisional; Region: PRK01212 644651002176 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644651002177 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 644651002178 threonine synthase; Validated; Region: PRK09225 644651002179 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 644651002180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651002181 catalytic residue [active] 644651002182 hypothetical protein; Validated; Region: PRK02101 644651002183 transaldolase-like protein; Provisional; Region: PTZ00411 644651002184 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 644651002185 active site 644651002186 dimer interface [polypeptide binding]; other site 644651002187 catalytic residue [active] 644651002188 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 644651002189 MPT binding site; other site 644651002190 trimer interface [polypeptide binding]; other site 644651002191 Transposase; Region: DDE_Tnp_ISL3; pfam01610 644651002192 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644651002193 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 644651002194 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644651002195 nucleotide binding site [chemical binding]; other site 644651002196 chaperone protein DnaJ; Provisional; Region: PRK10767 644651002197 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 644651002198 HSP70 interaction site [polypeptide binding]; other site 644651002199 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 644651002200 substrate binding site [polypeptide binding]; other site 644651002201 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 644651002202 Zn binding sites [ion binding]; other site 644651002203 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 644651002204 dimer interface [polypeptide binding]; other site 644651002205 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 644651002206 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 644651002207 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 644651002208 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 644651002209 active site 644651002210 Riboflavin kinase; Region: Flavokinase; smart00904 644651002211 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 644651002212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644651002213 active site 644651002214 HIGH motif; other site 644651002215 nucleotide binding site [chemical binding]; other site 644651002216 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 644651002217 active site 644651002218 KMSKS motif; other site 644651002219 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 644651002220 tRNA binding surface [nucleotide binding]; other site 644651002221 anticodon binding site; other site 644651002222 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644651002223 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 644651002224 lipoprotein signal peptidase; Provisional; Region: PRK14787 644651002225 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 644651002226 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644651002227 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 644651002228 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 644651002229 dihydrodipicolinate reductase; Provisional; Region: PRK00048 644651002230 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 644651002231 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 644651002232 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 644651002233 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 644651002234 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 644651002235 catalytic site [active] 644651002236 subunit interface [polypeptide binding]; other site 644651002237 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 644651002238 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644651002239 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 644651002240 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 644651002241 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644651002242 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644651002243 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 644651002244 IMP binding site; other site 644651002245 dimer interface [polypeptide binding]; other site 644651002246 interdomain contacts; other site 644651002247 partial ornithine binding site; other site 644651002248 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 644651002249 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 644651002250 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 644651002251 folate binding site [chemical binding]; other site 644651002252 NADP+ binding site [chemical binding]; other site 644651002253 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 644651002254 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 644651002255 active site 644651002256 metal binding site [ion binding]; metal-binding site 644651002257 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 644651002258 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 644651002259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651002260 S-adenosylmethionine binding site [chemical binding]; other site 644651002261 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 644651002262 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 644651002263 SurA N-terminal domain; Region: SurA_N; pfam09312 644651002264 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 644651002265 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 644651002266 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 644651002267 OstA-like protein; Region: OstA; pfam03968 644651002268 Organic solvent tolerance protein; Region: OstA_C; pfam04453 644651002269 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 644651002270 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 644651002271 putative metal binding site [ion binding]; other site 644651002272 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 644651002273 HSP70 interaction site [polypeptide binding]; other site 644651002274 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644651002275 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644651002276 active site 644651002277 ATP-dependent helicase HepA; Validated; Region: PRK04914 644651002278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651002279 ATP binding site [chemical binding]; other site 644651002280 putative Mg++ binding site [ion binding]; other site 644651002281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651002282 nucleotide binding region [chemical binding]; other site 644651002283 ATP-binding site [chemical binding]; other site 644651002284 DNA polymerase II; Reviewed; Region: PRK05762 644651002285 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 644651002286 active site 644651002287 catalytic site [active] 644651002288 substrate binding site [chemical binding]; other site 644651002289 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 644651002290 active site 644651002291 metal-binding site 644651002292 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644651002293 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 644651002294 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 644651002295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651002296 Walker A/P-loop; other site 644651002297 ATP binding site [chemical binding]; other site 644651002298 Q-loop/lid; other site 644651002299 ABC transporter signature motif; other site 644651002300 Walker B; other site 644651002301 D-loop; other site 644651002302 H-loop/switch region; other site 644651002303 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 644651002304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651002305 dimer interface [polypeptide binding]; other site 644651002306 conserved gate region; other site 644651002307 putative PBP binding loops; other site 644651002308 ABC-ATPase subunit interface; other site 644651002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651002310 dimer interface [polypeptide binding]; other site 644651002311 conserved gate region; other site 644651002312 putative PBP binding loops; other site 644651002313 ABC-ATPase subunit interface; other site 644651002314 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 644651002315 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 644651002316 transcriptional regulator SgrR; Provisional; Region: PRK13626 644651002317 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 644651002318 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 644651002319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651002320 sugar efflux transporter; Region: 2A0120; TIGR00899 644651002321 putative substrate translocation pore; other site 644651002322 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 644651002323 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 644651002324 substrate binding site [chemical binding]; other site 644651002325 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 644651002326 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 644651002327 substrate binding site [chemical binding]; other site 644651002328 ligand binding site [chemical binding]; other site 644651002329 tartrate dehydrogenase; Region: TTC; TIGR02089 644651002330 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 644651002331 2-isopropylmalate synthase; Validated; Region: PRK00915 644651002332 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 644651002333 active site 644651002334 catalytic residues [active] 644651002335 metal binding site [ion binding]; metal-binding site 644651002336 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 644651002337 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 644651002338 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644651002339 PYR/PP interface [polypeptide binding]; other site 644651002340 dimer interface [polypeptide binding]; other site 644651002341 TPP binding site [chemical binding]; other site 644651002342 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644651002343 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 644651002344 TPP-binding site [chemical binding]; other site 644651002345 dimer interface [polypeptide binding]; other site 644651002346 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 644651002347 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 644651002348 putative valine binding site [chemical binding]; other site 644651002349 dimer interface [polypeptide binding]; other site 644651002350 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 644651002351 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 644651002352 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651002353 DNA binding site [nucleotide binding] 644651002354 domain linker motif; other site 644651002355 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 644651002356 dimerization interface [polypeptide binding]; other site 644651002357 ligand binding site [chemical binding]; other site 644651002358 cell division protein MraZ; Reviewed; Region: PRK00326 644651002359 MraZ protein; Region: MraZ; pfam02381 644651002360 MraZ protein; Region: MraZ; pfam02381 644651002361 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 644651002362 MraW methylase family; Region: Methyltransf_5; pfam01795 644651002363 cell division protein FtsL; Provisional; Region: PRK10772 644651002364 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 644651002365 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644651002366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644651002367 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 644651002368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644651002369 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644651002370 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 644651002371 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644651002372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644651002373 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 644651002374 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 644651002375 Mg++ binding site [ion binding]; other site 644651002376 putative catalytic motif [active] 644651002377 putative substrate binding site [chemical binding]; other site 644651002378 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 644651002379 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644651002380 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644651002381 cell division protein FtsW; Provisional; Region: PRK10774 644651002382 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 644651002383 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 644651002384 active site 644651002385 homodimer interface [polypeptide binding]; other site 644651002386 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 644651002387 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644651002388 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644651002389 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644651002390 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 644651002391 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 644651002392 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 644651002393 cell division protein FtsQ; Provisional; Region: PRK10775 644651002394 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 644651002395 Cell division protein FtsQ; Region: FtsQ; pfam03799 644651002396 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 644651002397 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644651002398 Cell division protein FtsA; Region: FtsA; pfam14450 644651002399 cell division protein FtsZ; Validated; Region: PRK09330 644651002400 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 644651002401 nucleotide binding site [chemical binding]; other site 644651002402 SulA interaction site; other site 644651002403 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 644651002404 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 644651002405 Protein of unknown function (DUF721); Region: DUF721; cl02324 644651002406 SecA regulator SecM; Provisional; Region: PRK02943 644651002407 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 644651002408 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 644651002409 SEC-C motif; Region: SEC-C; pfam02810 644651002410 HTH-like domain; Region: HTH_21; pfam13276 644651002411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 644651002412 Integrase core domain; Region: rve; pfam00665 644651002413 Integrase core domain; Region: rve_3; pfam13683 644651002414 Transposase; Region: HTH_Tnp_1; pfam01527 644651002415 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 644651002416 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 644651002417 Chitin binding domain; Region: Chitin_bind_3; pfam03067 644651002418 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 644651002419 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 644651002420 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 644651002421 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 644651002422 GspL periplasmic domain; Region: GspL_C; cl14909 644651002423 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 644651002424 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 644651002425 type II secretion system protein J; Region: gspJ; TIGR01711 644651002426 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 644651002427 type II secretion system protein I; Region: gspI; TIGR01707 644651002428 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 644651002429 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 644651002430 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 644651002431 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 644651002432 type II secretion system protein F; Region: GspF; TIGR02120 644651002433 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644651002434 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644651002435 type II secretion system protein E; Region: type_II_gspE; TIGR02533 644651002436 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 644651002437 Walker A motif; other site 644651002438 ATP binding site [chemical binding]; other site 644651002439 Walker B motif; other site 644651002440 type II secretion system protein D; Region: type_II_gspD; TIGR02517 644651002441 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651002442 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651002443 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651002444 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 644651002445 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 644651002446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 644651002447 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 644651002448 active site 644651002449 8-oxo-dGMP binding site [chemical binding]; other site 644651002450 nudix motif; other site 644651002451 metal binding site [ion binding]; metal-binding site 644651002452 DNA gyrase inhibitor; Reviewed; Region: PRK00418 644651002453 hypothetical protein; Provisional; Region: PRK05287 644651002454 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 644651002455 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 644651002456 CoA-binding site [chemical binding]; other site 644651002457 ATP-binding [chemical binding]; other site 644651002458 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 644651002459 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 644651002460 active site 644651002461 type IV pilin biogenesis protein; Provisional; Region: PRK10573 644651002462 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644651002463 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644651002464 hypothetical protein; Provisional; Region: PRK10436 644651002465 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 644651002466 Walker A motif; other site 644651002467 ATP binding site [chemical binding]; other site 644651002468 Walker B motif; other site 644651002469 putative major pilin subunit; Provisional; Region: PRK10574 644651002470 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 644651002471 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 644651002472 dimerization interface [polypeptide binding]; other site 644651002473 active site 644651002474 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 644651002475 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 644651002476 amidase catalytic site [active] 644651002477 Zn binding residues [ion binding]; other site 644651002478 substrate binding site [chemical binding]; other site 644651002479 regulatory protein AmpE; Provisional; Region: PRK10987 644651002480 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 644651002481 active site 644651002482 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 644651002483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651002484 putative substrate translocation pore; other site 644651002485 aromatic amino acid transporter; Provisional; Region: PRK10238 644651002486 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 644651002487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651002488 DNA-binding site [nucleotide binding]; DNA binding site 644651002489 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 644651002490 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 644651002491 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 644651002492 dimer interface [polypeptide binding]; other site 644651002493 TPP-binding site [chemical binding]; other site 644651002494 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 644651002495 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644651002496 E3 interaction surface; other site 644651002497 lipoyl attachment site [posttranslational modification]; other site 644651002498 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644651002499 E3 interaction surface; other site 644651002500 lipoyl attachment site [posttranslational modification]; other site 644651002501 e3 binding domain; Region: E3_binding; pfam02817 644651002502 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 644651002503 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 644651002504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 644651002505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644651002506 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644651002507 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 644651002508 classical (c) SDRs; Region: SDR_c; cd05233 644651002509 NAD(P) binding site [chemical binding]; other site 644651002510 active site 644651002511 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644651002512 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644651002513 Walker A/P-loop; other site 644651002514 ATP binding site [chemical binding]; other site 644651002515 Q-loop/lid; other site 644651002516 ABC transporter signature motif; other site 644651002517 Walker B; other site 644651002518 D-loop; other site 644651002519 H-loop/switch region; other site 644651002520 Cobalt transport protein; Region: CbiQ; cl00463 644651002521 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 644651002522 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644651002523 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 644651002524 NADP binding site [chemical binding]; other site 644651002525 dimer interface [polypeptide binding]; other site 644651002526 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644651002527 active site 644651002528 acyl-CoA synthetase; Validated; Region: PRK07638 644651002529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644651002530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644651002531 acyl-activating enzyme (AAE) consensus motif; other site 644651002532 acyl-activating enzyme (AAE) consensus motif; other site 644651002533 AMP binding site [chemical binding]; other site 644651002534 active site 644651002535 CoA binding site [chemical binding]; other site 644651002536 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 644651002537 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 644651002538 dimer interface [polypeptide binding]; other site 644651002539 active site 644651002540 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 644651002541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644651002542 substrate binding site [chemical binding]; other site 644651002543 oxyanion hole (OAH) forming residues; other site 644651002544 trimer interface [polypeptide binding]; other site 644651002545 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 644651002546 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 644651002547 helicase Cas3; Provisional; Region: PRK09694 644651002548 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 644651002549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 644651002550 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 644651002551 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 644651002552 CT1975-like protein; Region: Cas_CT1975; pfam09344 644651002553 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 644651002554 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 644651002555 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 644651002556 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 644651002557 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 644651002558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 644651002559 DNA binding site [nucleotide binding] 644651002560 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 644651002561 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 644651002562 substrate binding site [chemical binding]; other site 644651002563 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 644651002564 substrate binding site [chemical binding]; other site 644651002565 ligand binding site [chemical binding]; other site 644651002566 hypothetical protein; Provisional; Region: PRK05248 644651002567 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 644651002568 spermidine synthase; Provisional; Region: PRK00811 644651002569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651002570 S-adenosylmethionine binding site [chemical binding]; other site 644651002571 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 644651002572 multicopper oxidase; Provisional; Region: PRK10965 644651002573 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 644651002574 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 644651002575 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 644651002576 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 644651002577 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 644651002578 Protein of unknown function (DUF497); Region: DUF497; pfam04365 644651002579 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 644651002580 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 644651002581 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 644651002582 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 644651002583 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 644651002584 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644651002585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651002586 DNA binding residues [nucleotide binding] 644651002587 dimerization interface [polypeptide binding]; other site 644651002588 methionine gamma-lyase; Validated; Region: PRK07049 644651002589 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 644651002590 homodimer interface [polypeptide binding]; other site 644651002591 substrate-cofactor binding pocket; other site 644651002592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651002593 catalytic residue [active] 644651002594 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 644651002595 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651002596 active site 644651002597 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 644651002598 active site clefts [active] 644651002599 zinc binding site [ion binding]; other site 644651002600 dimer interface [polypeptide binding]; other site 644651002601 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644651002602 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644651002603 Walker A/P-loop; other site 644651002604 ATP binding site [chemical binding]; other site 644651002605 Q-loop/lid; other site 644651002606 ABC transporter signature motif; other site 644651002607 Walker B; other site 644651002608 D-loop; other site 644651002609 H-loop/switch region; other site 644651002610 inner membrane transport permease; Provisional; Region: PRK15066 644651002611 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 644651002612 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 644651002613 tetramerization interface [polypeptide binding]; other site 644651002614 active site 644651002615 Pantoate-beta-alanine ligase; Region: PanC; cd00560 644651002616 pantoate--beta-alanine ligase; Region: panC; TIGR00018 644651002617 active site 644651002618 ATP-binding site [chemical binding]; other site 644651002619 pantoate-binding site; other site 644651002620 HXXH motif; other site 644651002621 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 644651002622 oligomerization interface [polypeptide binding]; other site 644651002623 active site 644651002624 metal binding site [ion binding]; metal-binding site 644651002625 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 644651002626 catalytic center binding site [active] 644651002627 ATP binding site [chemical binding]; other site 644651002628 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 644651002629 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 644651002630 active site 644651002631 NTP binding site [chemical binding]; other site 644651002632 metal binding triad [ion binding]; metal-binding site 644651002633 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 644651002634 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 644651002635 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 644651002636 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 644651002637 active site 644651002638 nucleotide binding site [chemical binding]; other site 644651002639 HIGH motif; other site 644651002640 KMSKS motif; other site 644651002641 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 644651002642 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 644651002643 2'-5' RNA ligase; Provisional; Region: PRK15124 644651002644 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 644651002645 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 644651002646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651002647 ATP binding site [chemical binding]; other site 644651002648 putative Mg++ binding site [ion binding]; other site 644651002649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651002650 nucleotide binding region [chemical binding]; other site 644651002651 ATP-binding site [chemical binding]; other site 644651002652 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 644651002653 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 644651002654 Transglycosylase; Region: Transgly; pfam00912 644651002655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 644651002656 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 644651002657 PAAR motif; Region: PAAR_motif; pfam05488 644651002658 RHS Repeat; Region: RHS_repeat; pfam05593 644651002659 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 644651002660 RHS Repeat; Region: RHS_repeat; pfam05593 644651002661 RHS Repeat; Region: RHS_repeat; pfam05593 644651002662 RHS Repeat; Region: RHS_repeat; pfam05593 644651002663 RHS protein; Region: RHS; pfam03527 644651002664 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651002665 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 644651002666 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 644651002667 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 644651002668 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 644651002669 N-terminal plug; other site 644651002670 ligand-binding site [chemical binding]; other site 644651002671 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 644651002672 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644651002673 Walker A/P-loop; other site 644651002674 ATP binding site [chemical binding]; other site 644651002675 Q-loop/lid; other site 644651002676 ABC transporter signature motif; other site 644651002677 Walker B; other site 644651002678 D-loop; other site 644651002679 H-loop/switch region; other site 644651002680 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 644651002681 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 644651002682 siderophore binding site; other site 644651002683 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 644651002684 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644651002685 ABC-ATPase subunit interface; other site 644651002686 dimer interface [polypeptide binding]; other site 644651002687 putative PBP binding regions; other site 644651002688 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644651002689 ABC-ATPase subunit interface; other site 644651002690 dimer interface [polypeptide binding]; other site 644651002691 putative PBP binding regions; other site 644651002692 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 644651002693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644651002694 inhibitor-cofactor binding pocket; inhibition site 644651002695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651002696 catalytic residue [active] 644651002697 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 644651002698 Protein of unknown function (DUF979); Region: DUF979; cl01572 644651002699 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 644651002700 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 644651002701 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 644651002702 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644651002703 Zn2+ binding site [ion binding]; other site 644651002704 Mg2+ binding site [ion binding]; other site 644651002705 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 644651002706 serine endoprotease; Provisional; Region: PRK10942 644651002707 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644651002708 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644651002709 protein binding site [polypeptide binding]; other site 644651002710 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644651002711 hypothetical protein; Provisional; Region: PRK13677 644651002712 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 644651002713 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 644651002714 trimer interface [polypeptide binding]; other site 644651002715 active site 644651002716 substrate binding site [chemical binding]; other site 644651002717 CoA binding site [chemical binding]; other site 644651002718 PII uridylyl-transferase; Provisional; Region: PRK05007 644651002719 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 644651002720 metal binding triad; other site 644651002721 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 644651002722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644651002723 Zn2+ binding site [ion binding]; other site 644651002724 Mg2+ binding site [ion binding]; other site 644651002725 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 644651002726 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 644651002727 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 644651002728 active site 644651002729 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 644651002730 rRNA interaction site [nucleotide binding]; other site 644651002731 S8 interaction site; other site 644651002732 putative laminin-1 binding site; other site 644651002733 elongation factor Ts; Provisional; Region: tsf; PRK09377 644651002734 UBA/TS-N domain; Region: UBA; pfam00627 644651002735 Elongation factor TS; Region: EF_TS; pfam00889 644651002736 Elongation factor TS; Region: EF_TS; pfam00889 644651002737 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 644651002738 putative nucleotide binding site [chemical binding]; other site 644651002739 uridine monophosphate binding site [chemical binding]; other site 644651002740 homohexameric interface [polypeptide binding]; other site 644651002741 ribosome recycling factor; Reviewed; Region: frr; PRK00083 644651002742 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 644651002743 hinge region; other site 644651002744 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 644651002745 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 644651002746 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 644651002747 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 644651002748 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 644651002749 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 644651002750 catalytic residue [active] 644651002751 putative FPP diphosphate binding site; other site 644651002752 putative FPP binding hydrophobic cleft; other site 644651002753 dimer interface [polypeptide binding]; other site 644651002754 putative IPP diphosphate binding site; other site 644651002755 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 644651002756 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 644651002757 zinc metallopeptidase RseP; Provisional; Region: PRK10779 644651002758 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 644651002759 active site 644651002760 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 644651002761 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 644651002762 protein binding site [polypeptide binding]; other site 644651002763 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 644651002764 putative substrate binding region [chemical binding]; other site 644651002765 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 644651002766 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 644651002767 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 644651002768 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 644651002769 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 644651002770 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 644651002771 Surface antigen; Region: Bac_surface_Ag; pfam01103 644651002772 periplasmic chaperone; Provisional; Region: PRK10780 644651002773 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 644651002774 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 644651002775 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 644651002776 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 644651002777 trimer interface [polypeptide binding]; other site 644651002778 active site 644651002779 UDP-GlcNAc binding site [chemical binding]; other site 644651002780 lipid binding site [chemical binding]; lipid-binding site 644651002781 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 644651002782 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 644651002783 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 644651002784 active site 644651002785 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 644651002786 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 644651002787 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 644651002788 RNA/DNA hybrid binding site [nucleotide binding]; other site 644651002789 active site 644651002790 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 644651002791 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 644651002792 putative active site [active] 644651002793 putative PHP Thumb interface [polypeptide binding]; other site 644651002794 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 644651002795 generic binding surface II; other site 644651002796 generic binding surface I; other site 644651002797 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 644651002798 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 644651002799 lysine decarboxylase LdcC; Provisional; Region: PRK15399 644651002800 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 644651002801 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 644651002802 homodimer interface [polypeptide binding]; other site 644651002803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651002804 catalytic residue [active] 644651002805 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 644651002806 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 644651002807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 644651002808 putative metal binding site [ion binding]; other site 644651002809 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 644651002810 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 644651002811 Ligand Binding Site [chemical binding]; other site 644651002812 TilS substrate binding domain; Region: TilS; pfam09179 644651002813 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 644651002814 Cytochrome c; Region: Cytochrom_C; cl11414 644651002815 Cytochrome c; Region: Cytochrom_C; cl11414 644651002816 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 644651002817 YaeQ protein; Region: YaeQ; pfam07152 644651002818 hypothetical protein; Provisional; Region: PRK09256 644651002819 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 644651002820 prolyl-tRNA synthetase; Provisional; Region: PRK09194 644651002821 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 644651002822 dimer interface [polypeptide binding]; other site 644651002823 motif 1; other site 644651002824 active site 644651002825 motif 2; other site 644651002826 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 644651002827 putative deacylase active site [active] 644651002828 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644651002829 active site 644651002830 motif 3; other site 644651002831 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 644651002832 anticodon binding site; other site 644651002833 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 644651002834 homodimer interaction site [polypeptide binding]; other site 644651002835 cofactor binding site; other site 644651002836 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 644651002837 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 644651002838 lipoprotein, YaeC family; Region: TIGR00363 644651002839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651002840 dimer interface [polypeptide binding]; other site 644651002841 conserved gate region; other site 644651002842 ABC-ATPase subunit interface; other site 644651002843 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 644651002844 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 644651002845 Walker A/P-loop; other site 644651002846 ATP binding site [chemical binding]; other site 644651002847 Q-loop/lid; other site 644651002848 ABC transporter signature motif; other site 644651002849 Walker B; other site 644651002850 D-loop; other site 644651002851 H-loop/switch region; other site 644651002852 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 644651002853 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 644651002854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651002855 active site 644651002856 motif I; other site 644651002857 motif II; other site 644651002858 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 644651002859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651002860 putative substrate translocation pore; other site 644651002861 lipoprotein; Provisional; Region: PRK10759 644651002862 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 644651002863 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 644651002864 domain interface [polypeptide binding]; other site 644651002865 putative active site [active] 644651002866 catalytic site [active] 644651002867 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 644651002868 domain interface [polypeptide binding]; other site 644651002869 putative active site [active] 644651002870 catalytic site [active] 644651002871 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 644651002872 CoA binding domain; Region: CoA_binding_2; pfam13380 644651002873 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 644651002874 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 644651002875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644651002876 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644651002877 Uncharacterized conserved protein [Function unknown]; Region: COG3148 644651002878 thioredoxin 2; Provisional; Region: PRK10996 644651002879 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 644651002880 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644651002881 catalytic residues [active] 644651002882 putative methyltransferase; Provisional; Region: PRK10864 644651002883 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 644651002884 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644651002885 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644651002886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651002887 putative substrate translocation pore; other site 644651002888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651002889 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 644651002890 ATP P2X receptor; Region: P2X_receptor; cl02993 644651002891 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 644651002892 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651002893 transcriptional repressor MprA; Provisional; Region: PRK10870 644651002894 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644651002895 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 644651002896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651002897 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 644651002898 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 644651002899 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 644651002900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651002901 dimer interface [polypeptide binding]; other site 644651002902 conserved gate region; other site 644651002903 putative PBP binding loops; other site 644651002904 ABC-ATPase subunit interface; other site 644651002905 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 644651002906 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 644651002907 Walker A/P-loop; other site 644651002908 ATP binding site [chemical binding]; other site 644651002909 Q-loop/lid; other site 644651002910 ABC transporter signature motif; other site 644651002911 Walker B; other site 644651002912 D-loop; other site 644651002913 H-loop/switch region; other site 644651002914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 644651002915 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 644651002916 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 644651002917 dimer interface [polypeptide binding]; other site 644651002918 putative radical transfer pathway; other site 644651002919 diiron center [ion binding]; other site 644651002920 tyrosyl radical; other site 644651002921 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 644651002922 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 644651002923 Class I ribonucleotide reductase; Region: RNR_I; cd01679 644651002924 active site 644651002925 dimer interface [polypeptide binding]; other site 644651002926 catalytic residues [active] 644651002927 effector binding site; other site 644651002928 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 644651002929 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 644651002930 catalytic residues [active] 644651002931 hypothetical protein; Provisional; Region: PRK10556 644651002932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651002933 Transposase; Region: HTH_Tnp_1; pfam01527 644651002934 putative transposase OrfB; Reviewed; Region: PHA02517 644651002935 HTH-like domain; Region: HTH_21; pfam13276 644651002936 Integrase core domain; Region: rve; pfam00665 644651002937 Integrase core domain; Region: rve_3; pfam13683 644651002938 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 644651002939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651002940 Coenzyme A binding pocket [chemical binding]; other site 644651002941 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 644651002942 Flagellar protein FlhE; Region: FlhE; pfam06366 644651002943 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 644651002944 FHIPEP family; Region: FHIPEP; pfam00771 644651002945 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 644651002946 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 644651002947 chemotaxis regulator CheZ; Provisional; Region: PRK11166 644651002948 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 644651002949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651002950 active site 644651002951 phosphorylation site [posttranslational modification] 644651002952 intermolecular recognition site; other site 644651002953 dimerization interface [polypeptide binding]; other site 644651002954 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 644651002955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651002956 active site 644651002957 phosphorylation site [posttranslational modification] 644651002958 intermolecular recognition site; other site 644651002959 dimerization interface [polypeptide binding]; other site 644651002960 CheB methylesterase; Region: CheB_methylest; pfam01339 644651002961 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 644651002962 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 644651002963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651002964 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 644651002965 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 644651002966 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 644651002967 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 644651002968 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 644651002969 FliG C-terminal domain; Region: FliG_C; pfam01706 644651002970 flagellar assembly protein H; Validated; Region: fliH; PRK05687 644651002971 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 644651002972 Flagellar assembly protein FliH; Region: FliH; pfam02108 644651002973 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 644651002974 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 644651002975 Walker A motif/ATP binding site; other site 644651002976 Walker B motif; other site 644651002977 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 644651002978 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 644651002979 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 644651002980 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 644651002981 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 644651002982 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 644651002983 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 644651002984 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 644651002985 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 644651002986 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 644651002987 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 644651002988 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 644651002989 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 644651002990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651002991 S-adenosylmethionine binding site [chemical binding]; other site 644651002992 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 644651002993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644651002994 TPR motif; other site 644651002995 binding surface 644651002996 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 644651002997 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 644651002998 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 644651002999 inhibitor-cofactor binding pocket; inhibition site 644651003000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651003001 catalytic residue [active] 644651003002 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 644651003003 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 644651003004 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 644651003005 trimer interface [polypeptide binding]; other site 644651003006 active site 644651003007 substrate binding site [chemical binding]; other site 644651003008 CoA binding site [chemical binding]; other site 644651003009 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 644651003010 DNA binding site [nucleotide binding] 644651003011 flagellin; Validated; Region: PRK08026 644651003012 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 644651003013 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 644651003014 flagellar capping protein; Reviewed; Region: fliD; PRK08032 644651003015 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 644651003016 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 644651003017 Flagellar protein FliS; Region: FliS; cl00654 644651003018 FlgN protein; Region: FlgN; cl09176 644651003019 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 644651003020 SAF-like; Region: SAF_2; pfam13144 644651003021 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 644651003022 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 644651003023 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 644651003024 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 644651003025 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 644651003026 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 644651003027 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 644651003028 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 644651003029 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 644651003030 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 644651003031 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 644651003032 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 644651003033 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 644651003034 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 644651003035 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 644651003036 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 644651003037 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 644651003038 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 644651003039 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 644651003040 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 644651003041 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 644651003042 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 644651003043 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 644651003044 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 644651003045 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 644651003046 potential frameshift: common BLAST hit: gi|385785582|ref|YP_005816691.1| Flagellar hook-associated protein 1, FlgK 644651003047 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 644651003048 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 644651003049 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 644651003050 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 644651003051 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 644651003052 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 644651003053 HAMP domain; Region: HAMP; pfam00672 644651003054 dimerization interface [polypeptide binding]; other site 644651003055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651003056 dimer interface [polypeptide binding]; other site 644651003057 putative CheW interface [polypeptide binding]; other site 644651003058 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 644651003059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644651003060 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644651003061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644651003062 DNA binding residues [nucleotide binding] 644651003063 transcriptional activator FlhD; Provisional; Region: PRK02909 644651003064 transcriptional activator FlhC; Provisional; Region: PRK12722 644651003065 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 644651003066 flagellar motor protein MotA; Validated; Region: PRK09110 644651003067 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 644651003068 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 644651003069 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 644651003070 ligand binding site [chemical binding]; other site 644651003071 chemotaxis protein CheA; Provisional; Region: PRK10547 644651003072 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 644651003073 putative binding surface; other site 644651003074 active site 644651003075 CheY binding; Region: CheY-binding; pfam09078 644651003076 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 644651003077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651003078 ATP binding site [chemical binding]; other site 644651003079 Mg2+ binding site [ion binding]; other site 644651003080 G-X-G motif; other site 644651003081 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 644651003082 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 644651003083 putative CheA interaction surface; other site 644651003084 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 644651003085 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 644651003086 Restriction endonuclease; Region: Mrr_cat; pfam04471 644651003087 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 644651003088 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 644651003089 putative transposase OrfB; Reviewed; Region: PHA02517 644651003090 HTH-like domain; Region: HTH_21; pfam13276 644651003091 Integrase core domain; Region: rve; pfam00665 644651003092 Integrase core domain; Region: rve_3; pfam13683 644651003093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651003094 Transposase; Region: HTH_Tnp_1; pfam01527 644651003095 potential frameshift: common BLAST hit: gi|292488797|ref|YP_003531684.1| superfamily I DNA and RNA helicase and helicase subunits-like 644651003096 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 644651003097 Part of AAA domain; Region: AAA_19; pfam13245 644651003098 HTH-like domain; Region: HTH_21; pfam13276 644651003099 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 644651003100 SmpB-tmRNA interface; other site 644651003101 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 644651003102 putative coenzyme Q binding site [chemical binding]; other site 644651003103 hypothetical protein; Validated; Region: PRK01777 644651003104 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 644651003105 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 644651003106 recombination and repair protein; Provisional; Region: PRK10869 644651003107 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 644651003108 Walker A/P-loop; other site 644651003109 ATP binding site [chemical binding]; other site 644651003110 Q-loop/lid; other site 644651003111 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 644651003112 ABC transporter signature motif; other site 644651003113 Walker B; other site 644651003114 D-loop; other site 644651003115 H-loop/switch region; other site 644651003116 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 644651003117 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 644651003118 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 644651003119 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 644651003120 dimer interface [polypeptide binding]; other site 644651003121 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 644651003122 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 644651003123 ligand binding site [chemical binding]; other site 644651003124 active site 644651003125 UGI interface [polypeptide binding]; other site 644651003126 catalytic site [active] 644651003127 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 644651003128 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 644651003129 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644651003130 ATP binding site [chemical binding]; other site 644651003131 Mg++ binding site [ion binding]; other site 644651003132 motif III; other site 644651003133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651003134 nucleotide binding region [chemical binding]; other site 644651003135 ATP-binding site [chemical binding]; other site 644651003136 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 644651003137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651003138 S-adenosylmethionine binding site [chemical binding]; other site 644651003139 L-aspartate oxidase; Provisional; Region: PRK09077 644651003140 L-aspartate oxidase; Provisional; Region: PRK06175 644651003141 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 644651003142 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 644651003143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644651003144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644651003145 DNA binding residues [nucleotide binding] 644651003146 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 644651003147 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 644651003148 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 644651003149 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 644651003150 anti-sigma E factor; Provisional; Region: rseB; PRK09455 644651003151 SoxR reducing system protein RseC; Provisional; Region: PRK10862 644651003152 Antitermination protein; Region: Antiterm; pfam03589 644651003153 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 644651003154 GTP-binding protein LepA; Provisional; Region: PRK05433 644651003155 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 644651003156 G1 box; other site 644651003157 putative GEF interaction site [polypeptide binding]; other site 644651003158 GTP/Mg2+ binding site [chemical binding]; other site 644651003159 Switch I region; other site 644651003160 G2 box; other site 644651003161 G3 box; other site 644651003162 Switch II region; other site 644651003163 G4 box; other site 644651003164 G5 box; other site 644651003165 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 644651003166 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 644651003167 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 644651003168 signal peptidase I; Provisional; Region: PRK10861 644651003169 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644651003170 Catalytic site [active] 644651003171 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644651003172 ribonuclease III; Reviewed; Region: rnc; PRK00102 644651003173 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 644651003174 dimerization interface [polypeptide binding]; other site 644651003175 active site 644651003176 metal binding site [ion binding]; metal-binding site 644651003177 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 644651003178 dsRNA binding site [nucleotide binding]; other site 644651003179 GTPase Era; Reviewed; Region: era; PRK00089 644651003180 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 644651003181 G1 box; other site 644651003182 GTP/Mg2+ binding site [chemical binding]; other site 644651003183 Switch I region; other site 644651003184 G2 box; other site 644651003185 Switch II region; other site 644651003186 G3 box; other site 644651003187 G4 box; other site 644651003188 G5 box; other site 644651003189 KH domain; Region: KH_2; pfam07650 644651003190 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 644651003191 Recombination protein O N terminal; Region: RecO_N; pfam11967 644651003192 Recombination protein O C terminal; Region: RecO_C; pfam02565 644651003193 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 644651003194 active site 644651003195 hydrophilic channel; other site 644651003196 dimerization interface [polypeptide binding]; other site 644651003197 catalytic residues [active] 644651003198 active site lid [active] 644651003199 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 644651003200 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644651003201 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 644651003202 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644651003203 putative active site [active] 644651003204 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 644651003205 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 644651003206 putative active site [active] 644651003207 hypothetical protein; Provisional; Region: PRK11590 644651003208 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 644651003209 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 644651003210 nucleoside/Zn binding site; other site 644651003211 dimer interface [polypeptide binding]; other site 644651003212 catalytic motif [active] 644651003213 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 644651003214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651003215 substrate binding pocket [chemical binding]; other site 644651003216 membrane-bound complex binding site; other site 644651003217 hinge residues; other site 644651003218 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644651003219 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644651003220 catalytic residue [active] 644651003221 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 644651003222 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 644651003223 dimerization interface [polypeptide binding]; other site 644651003224 ATP binding site [chemical binding]; other site 644651003225 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 644651003226 dimerization interface [polypeptide binding]; other site 644651003227 ATP binding site [chemical binding]; other site 644651003228 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 644651003229 putative active site [active] 644651003230 catalytic triad [active] 644651003231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644651003232 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 644651003233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651003234 dimer interface [polypeptide binding]; other site 644651003235 phosphorylation site [posttranslational modification] 644651003236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651003237 ATP binding site [chemical binding]; other site 644651003238 Mg2+ binding site [ion binding]; other site 644651003239 G-X-G motif; other site 644651003240 hypothetical protein; Provisional; Region: PRK10722 644651003241 response regulator GlrR; Provisional; Region: PRK15115 644651003242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651003243 active site 644651003244 phosphorylation site [posttranslational modification] 644651003245 intermolecular recognition site; other site 644651003246 dimerization interface [polypeptide binding]; other site 644651003247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651003248 Walker A motif; other site 644651003249 ATP binding site [chemical binding]; other site 644651003250 Walker B motif; other site 644651003251 arginine finger; other site 644651003252 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 644651003253 Nitrogen regulatory protein P-II; Region: P-II; smart00938 644651003254 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 644651003255 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 644651003256 dimer interface [polypeptide binding]; other site 644651003257 active site 644651003258 glycine-pyridoxal phosphate binding site [chemical binding]; other site 644651003259 folate binding site [chemical binding]; other site 644651003260 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 644651003261 PRD domain; Region: PRD; pfam00874 644651003262 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 644651003263 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 644651003264 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 644651003265 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 644651003266 active site 644651003267 dimerization interface [polypeptide binding]; other site 644651003268 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 644651003269 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644651003270 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 644651003271 Rrf2 family protein; Region: rrf2_super; TIGR00738 644651003272 cysteine desulfurase; Provisional; Region: PRK14012 644651003273 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 644651003274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651003275 catalytic residue [active] 644651003276 aminopeptidase B; Provisional; Region: PRK05015 644651003277 Peptidase; Region: DUF3663; pfam12404 644651003278 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 644651003279 interface (dimer of trimers) [polypeptide binding]; other site 644651003280 Substrate-binding/catalytic site; other site 644651003281 Zn-binding sites [ion binding]; other site 644651003282 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 644651003283 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 644651003284 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 644651003285 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 644651003286 inhibitor site; inhibition site 644651003287 active site 644651003288 dimer interface [polypeptide binding]; other site 644651003289 catalytic residue [active] 644651003290 Transcriptional regulators [Transcription]; Region: GntR; COG1802 644651003291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651003292 DNA-binding site [nucleotide binding]; DNA binding site 644651003293 FCD domain; Region: FCD; pfam07729 644651003294 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 644651003295 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 644651003296 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 644651003297 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 644651003298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 644651003299 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 644651003300 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 644651003301 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 644651003302 dimer interface [polypeptide binding]; other site 644651003303 NADP binding site [chemical binding]; other site 644651003304 catalytic residues [active] 644651003305 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 644651003306 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 644651003307 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 644651003308 active site residue [active] 644651003309 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 644651003310 active site residue [active] 644651003311 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 644651003312 active site 644651003313 multimer interface [polypeptide binding]; other site 644651003314 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 644651003315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651003316 FeS/SAM binding site; other site 644651003317 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 644651003318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644651003319 binding surface 644651003320 TPR motif; other site 644651003321 cytoskeletal protein RodZ; Provisional; Region: PRK10856 644651003322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651003323 non-specific DNA binding site [nucleotide binding]; other site 644651003324 salt bridge; other site 644651003325 sequence-specific DNA binding site [nucleotide binding]; other site 644651003326 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 644651003327 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 644651003328 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 644651003329 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 644651003330 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 644651003331 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 644651003332 dimer interface [polypeptide binding]; other site 644651003333 motif 1; other site 644651003334 active site 644651003335 motif 2; other site 644651003336 motif 3; other site 644651003337 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 644651003338 anticodon binding site; other site 644651003339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 644651003340 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 644651003341 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 644651003342 Trp docking motif [polypeptide binding]; other site 644651003343 GTP-binding protein Der; Reviewed; Region: PRK00093 644651003344 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 644651003345 G1 box; other site 644651003346 GTP/Mg2+ binding site [chemical binding]; other site 644651003347 Switch I region; other site 644651003348 G2 box; other site 644651003349 Switch II region; other site 644651003350 G3 box; other site 644651003351 G4 box; other site 644651003352 G5 box; other site 644651003353 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 644651003354 G1 box; other site 644651003355 GTP/Mg2+ binding site [chemical binding]; other site 644651003356 Switch I region; other site 644651003357 G2 box; other site 644651003358 G3 box; other site 644651003359 Switch II region; other site 644651003360 G4 box; other site 644651003361 G5 box; other site 644651003362 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 644651003363 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 644651003364 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 644651003365 Trp docking motif [polypeptide binding]; other site 644651003366 putative active site [active] 644651003367 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 644651003368 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 644651003369 active site 644651003370 Zn binding site [ion binding]; other site 644651003371 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 644651003372 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 644651003373 generic binding surface II; other site 644651003374 generic binding surface I; other site 644651003375 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 644651003376 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 644651003377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 644651003378 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 644651003379 active site 644651003380 GMP synthase; Reviewed; Region: guaA; PRK00074 644651003381 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 644651003382 AMP/PPi binding site [chemical binding]; other site 644651003383 candidate oxyanion hole; other site 644651003384 catalytic triad [active] 644651003385 potential glutamine specificity residues [chemical binding]; other site 644651003386 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 644651003387 ATP Binding subdomain [chemical binding]; other site 644651003388 Ligand Binding sites [chemical binding]; other site 644651003389 Dimerization subdomain; other site 644651003390 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 644651003391 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 644651003392 FIC domain binding interface [polypeptide binding]; other site 644651003393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651003394 sequence-specific DNA binding site [nucleotide binding]; other site 644651003395 salt bridge; other site 644651003396 Predicted ATPase [General function prediction only]; Region: COG5293 644651003397 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 644651003398 putative transposase OrfB; Reviewed; Region: PHA02517 644651003399 HTH-like domain; Region: HTH_21; pfam13276 644651003400 Integrase core domain; Region: rve; pfam00665 644651003401 Integrase core domain; Region: rve_3; pfam13683 644651003402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651003403 Transposase; Region: HTH_Tnp_1; pfam01527 644651003404 Transposase; Region: HTH_Tnp_1; cl17663 644651003405 Transposase; Region: HTH_Tnp_1; pfam01527 644651003406 HTH-like domain; Region: HTH_21; pfam13276 644651003407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 644651003408 Integrase core domain; Region: rve; pfam00665 644651003409 Integrase core domain; Region: rve_3; pfam13683 644651003410 AAA domain; Region: AAA_13; pfam13166 644651003411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651003412 ABC transporter signature motif; other site 644651003413 Walker B; other site 644651003414 D-loop; other site 644651003415 H-loop/switch region; other site 644651003416 potential frameshift: common BLAST hit: gi|259907138|ref|YP_002647494.1| transposase 644651003417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651003418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651003419 MULE transposase domain; Region: MULE; pfam10551 644651003420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 644651003421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 644651003422 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644651003423 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644651003424 active site 644651003425 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644651003426 DNA-binding site [nucleotide binding]; DNA binding site 644651003427 RNA-binding motif; other site 644651003428 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644651003429 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 644651003430 putative NAD(P) binding site [chemical binding]; other site 644651003431 active site 644651003432 putative substrate binding site [chemical binding]; other site 644651003433 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 644651003434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651003435 putative substrate translocation pore; other site 644651003436 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 644651003437 MgtE intracellular N domain; Region: MgtE_N; smart00924 644651003438 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 644651003439 MASE1; Region: MASE1; cl17823 644651003440 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 644651003441 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644651003442 tellurite resistance protein TehB; Provisional; Region: PRK11207 644651003443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651003444 S-adenosylmethionine binding site [chemical binding]; other site 644651003445 exopolyphosphatase; Provisional; Region: PRK10854 644651003446 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644651003447 nucleotide binding site [chemical binding]; other site 644651003448 polyphosphate kinase; Provisional; Region: PRK05443 644651003449 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 644651003450 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 644651003451 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 644651003452 putative active site [active] 644651003453 catalytic site [active] 644651003454 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 644651003455 domain interface [polypeptide binding]; other site 644651003456 active site 644651003457 catalytic site [active] 644651003458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 644651003459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003460 conserved gate region; other site 644651003461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003462 dimer interface [polypeptide binding]; other site 644651003463 conserved gate region; other site 644651003464 putative PBP binding loops; other site 644651003465 ABC-ATPase subunit interface; other site 644651003466 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 644651003467 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 644651003468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003469 dimer interface [polypeptide binding]; other site 644651003470 conserved gate region; other site 644651003471 putative PBP binding loops; other site 644651003472 ABC-ATPase subunit interface; other site 644651003473 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 644651003474 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 644651003475 Walker A/P-loop; other site 644651003476 ATP binding site [chemical binding]; other site 644651003477 Q-loop/lid; other site 644651003478 ABC transporter signature motif; other site 644651003479 Walker B; other site 644651003480 D-loop; other site 644651003481 H-loop/switch region; other site 644651003482 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 644651003483 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 644651003484 active site 644651003485 substrate binding site [chemical binding]; other site 644651003486 cosubstrate binding site; other site 644651003487 catalytic site [active] 644651003488 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 644651003489 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 644651003490 dimerization interface [polypeptide binding]; other site 644651003491 putative ATP binding site [chemical binding]; other site 644651003492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651003493 active site 644651003494 uracil transporter; Provisional; Region: PRK10720 644651003495 DNA replication initiation factor; Provisional; Region: PRK08084 644651003496 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 644651003497 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644651003498 ArsC family; Region: ArsC; pfam03960 644651003499 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 644651003500 Peptidase family M48; Region: Peptidase_M48; pfam01435 644651003501 potential frameshift: common BLAST hit: gi|292900137|ref|YP_003539506.1| signal transduction protein 644651003502 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 644651003503 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644651003504 metal binding site [ion binding]; metal-binding site 644651003505 active site 644651003506 I-site; other site 644651003507 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 644651003508 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 644651003509 catalytic triad [active] 644651003510 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 644651003511 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 644651003512 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644651003513 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 644651003514 dihydrodipicolinate synthase; Region: dapA; TIGR00674 644651003515 dimer interface [polypeptide binding]; other site 644651003516 active site 644651003517 catalytic residue [active] 644651003518 lipoprotein; Provisional; Region: PRK11679 644651003519 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 644651003520 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 644651003521 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 644651003522 ATP binding site [chemical binding]; other site 644651003523 active site 644651003524 substrate binding site [chemical binding]; other site 644651003525 Predicted metalloprotease [General function prediction only]; Region: COG2321 644651003526 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 644651003527 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 644651003528 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 644651003529 Helicase; Region: Helicase_RecD; pfam05127 644651003530 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 644651003531 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 644651003532 Transposase; Region: HTH_Tnp_1; pfam01527 644651003533 HTH-like domain; Region: HTH_21; pfam13276 644651003534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 644651003535 Integrase core domain; Region: rve; pfam00665 644651003536 Integrase core domain; Region: rve_3; pfam13683 644651003537 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651003538 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651003539 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651003540 active site 644651003541 DNA binding site [nucleotide binding] 644651003542 Int/Topo IB signature motif; other site 644651003543 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651003544 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651003545 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 644651003546 active site 644651003547 metal binding site [ion binding]; metal-binding site 644651003548 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651003549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651003550 non-specific DNA binding site [nucleotide binding]; other site 644651003551 salt bridge; other site 644651003552 sequence-specific DNA binding site [nucleotide binding]; other site 644651003553 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 644651003554 PAAR motif; Region: PAAR_motif; pfam05488 644651003555 RHS Repeat; Region: RHS_repeat; pfam05593 644651003556 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 644651003557 RHS Repeat; Region: RHS_repeat; pfam05593 644651003558 RHS Repeat; Region: RHS_repeat; pfam05593 644651003559 RHS Repeat; Region: RHS_repeat; pfam05593 644651003560 RHS protein; Region: RHS; pfam03527 644651003561 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651003562 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 644651003563 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644651003564 CoA binding site [chemical binding]; other site 644651003565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 644651003566 Condensation domain; Region: Condensation; pfam00668 644651003567 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 644651003568 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 644651003569 acyl-activating enzyme (AAE) consensus motif; other site 644651003570 AMP binding site [chemical binding]; other site 644651003571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 644651003572 Condensation domain; Region: Condensation; pfam00668 644651003573 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 644651003574 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 644651003575 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 644651003576 acyl-activating enzyme (AAE) consensus motif; other site 644651003577 AMP binding site [chemical binding]; other site 644651003578 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 644651003579 Condensation domain; Region: Condensation; pfam00668 644651003580 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 644651003581 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 644651003582 acyl-activating enzyme (AAE) consensus motif; other site 644651003583 AMP binding site [chemical binding]; other site 644651003584 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 644651003585 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 644651003586 hypothetical protein; Provisional; Region: PRK13664 644651003587 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 644651003588 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 644651003589 metal binding site [ion binding]; metal-binding site 644651003590 dimer interface [polypeptide binding]; other site 644651003591 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 644651003592 ArsC family; Region: ArsC; pfam03960 644651003593 putative catalytic residues [active] 644651003594 Colicin pore forming domain; Region: Colicin; pfam01024 644651003595 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 644651003596 Protein export membrane protein; Region: SecD_SecF; cl14618 644651003597 transcriptional regulator NarP; Provisional; Region: PRK10403 644651003598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651003599 active site 644651003600 phosphorylation site [posttranslational modification] 644651003601 intermolecular recognition site; other site 644651003602 dimerization interface [polypeptide binding]; other site 644651003603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651003604 DNA binding residues [nucleotide binding] 644651003605 dimerization interface [polypeptide binding]; other site 644651003606 Histidine kinase; Region: HisKA_3; pfam07730 644651003607 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 644651003608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651003609 ATP binding site [chemical binding]; other site 644651003610 Mg2+ binding site [ion binding]; other site 644651003611 G-X-G motif; other site 644651003612 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 644651003613 L-asparagine permease; Provisional; Region: PRK15049 644651003614 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 644651003615 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 644651003616 dimer interface [polypeptide binding]; other site 644651003617 ADP-ribose binding site [chemical binding]; other site 644651003618 active site 644651003619 nudix motif; other site 644651003620 metal binding site [ion binding]; metal-binding site 644651003621 transketolase; Reviewed; Region: PRK12753 644651003622 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 644651003623 TPP-binding site [chemical binding]; other site 644651003624 dimer interface [polypeptide binding]; other site 644651003625 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644651003626 PYR/PP interface [polypeptide binding]; other site 644651003627 dimer interface [polypeptide binding]; other site 644651003628 TPP binding site [chemical binding]; other site 644651003629 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644651003630 transaldolase-like protein; Provisional; Region: PTZ00411 644651003631 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 644651003632 active site 644651003633 dimer interface [polypeptide binding]; other site 644651003634 catalytic residue [active] 644651003635 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 644651003636 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 644651003637 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 644651003638 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644651003639 active site 644651003640 metal binding site [ion binding]; metal-binding site 644651003641 putative acetyltransferase; Provisional; Region: PRK03624 644651003642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651003643 Coenzyme A binding pocket [chemical binding]; other site 644651003644 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 644651003645 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 644651003646 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 644651003647 thiosulfate transporter subunit; Provisional; Region: PRK10852 644651003648 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 644651003649 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 644651003650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003651 dimer interface [polypeptide binding]; other site 644651003652 conserved gate region; other site 644651003653 putative PBP binding loops; other site 644651003654 ABC-ATPase subunit interface; other site 644651003655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003656 dimer interface [polypeptide binding]; other site 644651003657 conserved gate region; other site 644651003658 putative PBP binding loops; other site 644651003659 ABC-ATPase subunit interface; other site 644651003660 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 644651003661 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 644651003662 Walker A/P-loop; other site 644651003663 ATP binding site [chemical binding]; other site 644651003664 Q-loop/lid; other site 644651003665 ABC transporter signature motif; other site 644651003666 Walker B; other site 644651003667 D-loop; other site 644651003668 H-loop/switch region; other site 644651003669 TOBE-like domain; Region: TOBE_3; pfam12857 644651003670 cysteine synthase B; Region: cysM; TIGR01138 644651003671 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 644651003672 dimer interface [polypeptide binding]; other site 644651003673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651003674 catalytic residue [active] 644651003675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644651003676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651003677 active site 644651003678 phosphorylation site [posttranslational modification] 644651003679 intermolecular recognition site; other site 644651003680 dimerization interface [polypeptide binding]; other site 644651003681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651003682 DNA binding site [nucleotide binding] 644651003683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651003684 dimerization interface [polypeptide binding]; other site 644651003685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651003686 dimer interface [polypeptide binding]; other site 644651003687 phosphorylation site [posttranslational modification] 644651003688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651003689 ATP binding site [chemical binding]; other site 644651003690 Mg2+ binding site [ion binding]; other site 644651003691 G-X-G motif; other site 644651003692 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 644651003693 HPr interaction site; other site 644651003694 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644651003695 active site 644651003696 phosphorylation site [posttranslational modification] 644651003697 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 644651003698 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 644651003699 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 644651003700 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 644651003701 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 644651003702 dimerization domain swap beta strand [polypeptide binding]; other site 644651003703 regulatory protein interface [polypeptide binding]; other site 644651003704 active site 644651003705 regulatory phosphorylation site [posttranslational modification]; other site 644651003706 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 644651003707 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 644651003708 dimer interface [polypeptide binding]; other site 644651003709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651003710 catalytic residue [active] 644651003711 putative sulfate transport protein CysZ; Validated; Region: PRK04949 644651003712 cell division protein ZipA; Provisional; Region: PRK03427 644651003713 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 644651003714 FtsZ protein binding site [polypeptide binding]; other site 644651003715 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 644651003716 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 644651003717 nucleotide binding pocket [chemical binding]; other site 644651003718 K-X-D-G motif; other site 644651003719 catalytic site [active] 644651003720 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 644651003721 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 644651003722 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 644651003723 Dimer interface [polypeptide binding]; other site 644651003724 BRCT sequence motif; other site 644651003725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 644651003726 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 644651003727 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 644651003728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651003729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651003730 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 644651003731 putative dimerization interface [polypeptide binding]; other site 644651003732 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 644651003733 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644651003734 active site 644651003735 HIGH motif; other site 644651003736 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644651003737 active site 644651003738 KMSKS motif; other site 644651003739 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 644651003740 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 644651003741 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 644651003742 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 644651003743 Nucleoside recognition; Region: Gate; pfam07670 644651003744 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 644651003745 manganese transport protein MntH; Reviewed; Region: PRK00701 644651003746 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 644651003747 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644651003748 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644651003749 active site 644651003750 catalytic tetrad [active] 644651003751 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 644651003752 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 644651003753 dimer interface [polypeptide binding]; other site 644651003754 PYR/PP interface [polypeptide binding]; other site 644651003755 TPP binding site [chemical binding]; other site 644651003756 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644651003757 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 644651003758 TPP-binding site [chemical binding]; other site 644651003759 dimer interface [polypeptide binding]; other site 644651003760 glucokinase; Provisional; Region: glk; PRK00292 644651003761 glucokinase, proteobacterial type; Region: glk; TIGR00749 644651003762 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644651003763 LytTr DNA-binding domain; Region: LytTR; pfam04397 644651003764 aminotransferase; Validated; Region: PRK08175 644651003765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651003766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651003767 homodimer interface [polypeptide binding]; other site 644651003768 catalytic residue [active] 644651003769 SopA-like central domain; Region: SopA; pfam13981 644651003770 SopA-like catalytic domain; Region: SopA_C; pfam13979 644651003771 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644651003772 Ligand Binding Site [chemical binding]; other site 644651003773 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 644651003774 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 644651003775 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644651003776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651003777 Transposase; Region: HTH_Tnp_1; cl17663 644651003778 Integrase core domain; Region: rve; pfam00665 644651003779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651003780 Transposase; Region: HTH_Tnp_1; pfam01527 644651003781 putative transposase OrfB; Reviewed; Region: PHA02517 644651003782 HTH-like domain; Region: HTH_21; pfam13276 644651003783 Integrase core domain; Region: rve; pfam00665 644651003784 Integrase core domain; Region: rve_3; pfam13683 644651003785 Integrase core domain; Region: rve; pfam00665 644651003786 Integrase core domain; Region: rve_2; pfam13333 644651003787 Transposase; Region: HTH_Tnp_1; cl17663 644651003788 BetR domain; Region: BetR; pfam08667 644651003789 Response regulator receiver domain; Region: Response_reg; pfam00072 644651003790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651003791 active site 644651003792 phosphorylation site [posttranslational modification] 644651003793 intermolecular recognition site; other site 644651003794 dimerization interface [polypeptide binding]; other site 644651003795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651003796 Coenzyme A binding pocket [chemical binding]; other site 644651003797 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 644651003798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644651003799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651003800 ATP binding site [chemical binding]; other site 644651003801 Mg2+ binding site [ion binding]; other site 644651003802 G-X-G motif; other site 644651003803 Homeodomain-like domain; Region: HTH_23; pfam13384 644651003804 Winged helix-turn helix; Region: HTH_29; pfam13551 644651003805 putative transposase OrfB; Reviewed; Region: PHA02517 644651003806 HTH-like domain; Region: HTH_21; pfam13276 644651003807 Integrase core domain; Region: rve; pfam00665 644651003808 Integrase core domain; Region: rve_3; pfam13683 644651003809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651003810 Transposase; Region: HTH_Tnp_1; pfam01527 644651003811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651003812 MULE transposase domain; Region: MULE; pfam10551 644651003813 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 644651003814 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 644651003815 Walker A/P-loop; other site 644651003816 ATP binding site [chemical binding]; other site 644651003817 Q-loop/lid; other site 644651003818 ABC transporter signature motif; other site 644651003819 Walker B; other site 644651003820 D-loop; other site 644651003821 H-loop/switch region; other site 644651003822 heme exporter protein CcmB; Region: ccmB; TIGR01190 644651003823 heme exporter protein CcmC; Region: ccmC; TIGR01191 644651003824 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 644651003825 CcmE; Region: CcmE; cl00994 644651003826 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 644651003827 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644651003828 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 644651003829 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 644651003830 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 644651003831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644651003832 binding surface 644651003833 TPR motif; other site 644651003834 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 644651003835 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 644651003836 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 644651003837 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 644651003838 dimer interface [polypeptide binding]; other site 644651003839 active site 644651003840 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 644651003841 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644651003842 substrate binding site [chemical binding]; other site 644651003843 oxyanion hole (OAH) forming residues; other site 644651003844 trimer interface [polypeptide binding]; other site 644651003845 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 644651003846 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 644651003847 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 644651003848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644651003849 catalytic core [active] 644651003850 hypothetical protein; Provisional; Region: PRK04946 644651003851 Smr domain; Region: Smr; pfam01713 644651003852 HemK family putative methylases; Region: hemK_fam; TIGR00536 644651003853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651003854 S-adenosylmethionine binding site [chemical binding]; other site 644651003855 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 644651003856 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 644651003857 Tetramer interface [polypeptide binding]; other site 644651003858 active site 644651003859 FMN-binding site [chemical binding]; other site 644651003860 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 644651003861 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 644651003862 hypothetical protein; Provisional; Region: PRK10621 644651003863 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644651003864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 644651003865 YfcL protein; Region: YfcL; pfam08891 644651003866 Homeodomain-like domain; Region: HTH_23; pfam13384 644651003867 Winged helix-turn helix; Region: HTH_29; pfam13551 644651003868 Homeodomain-like domain; Region: HTH_32; pfam13565 644651003869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651003870 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651003871 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 644651003872 Uncharacterized conserved protein [Function unknown]; Region: COG4121 644651003873 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 644651003874 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 644651003875 dimer interface [polypeptide binding]; other site 644651003876 active site 644651003877 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644651003878 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651003879 catalytic residue [active] 644651003880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651003881 DNA-binding site [nucleotide binding]; DNA binding site 644651003882 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 644651003883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651003884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651003885 homodimer interface [polypeptide binding]; other site 644651003886 catalytic residue [active] 644651003887 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 644651003888 active site residue [active] 644651003889 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 644651003890 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 644651003891 EamA-like transporter family; Region: EamA; pfam00892 644651003892 EamA-like transporter family; Region: EamA; pfam00892 644651003893 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 644651003894 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 644651003895 ligand binding site [chemical binding]; other site 644651003896 NAD binding site [chemical binding]; other site 644651003897 catalytic site [active] 644651003898 homodimer interface [polypeptide binding]; other site 644651003899 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 644651003900 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 644651003901 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 644651003902 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 644651003903 dimerization interface 3.5A [polypeptide binding]; other site 644651003904 active site 644651003905 hypothetical protein; Provisional; Region: PRK10847 644651003906 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644651003907 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 644651003908 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 644651003909 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 644651003910 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644651003911 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644651003912 cell division protein DedD; Provisional; Region: PRK11633 644651003913 Sporulation related domain; Region: SPOR; pfam05036 644651003914 colicin V production protein; Provisional; Region: PRK10845 644651003915 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 644651003916 amidophosphoribosyltransferase; Provisional; Region: PRK09246 644651003917 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 644651003918 active site 644651003919 tetramer interface [polypeptide binding]; other site 644651003920 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651003921 active site 644651003922 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 644651003923 Flavoprotein; Region: Flavoprotein; pfam02441 644651003924 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 644651003925 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651003926 substrate binding pocket [chemical binding]; other site 644651003927 membrane-bound complex binding site; other site 644651003928 hinge residues; other site 644651003929 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651003930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003931 dimer interface [polypeptide binding]; other site 644651003932 conserved gate region; other site 644651003933 putative PBP binding loops; other site 644651003934 ABC-ATPase subunit interface; other site 644651003935 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651003936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003937 dimer interface [polypeptide binding]; other site 644651003938 conserved gate region; other site 644651003939 putative PBP binding loops; other site 644651003940 ABC-ATPase subunit interface; other site 644651003941 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 644651003942 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644651003943 Walker A/P-loop; other site 644651003944 ATP binding site [chemical binding]; other site 644651003945 Q-loop/lid; other site 644651003946 ABC transporter signature motif; other site 644651003947 Walker B; other site 644651003948 D-loop; other site 644651003949 H-loop/switch region; other site 644651003950 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 644651003951 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 644651003952 putative NAD(P) binding site [chemical binding]; other site 644651003953 putative active site [active] 644651003954 glutathione S-transferase; Provisional; Region: PRK15113 644651003955 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 644651003956 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 644651003957 nudix motif; other site 644651003958 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644651003959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003960 dimer interface [polypeptide binding]; other site 644651003961 conserved gate region; other site 644651003962 putative PBP binding loops; other site 644651003963 ABC-ATPase subunit interface; other site 644651003964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651003965 dimer interface [polypeptide binding]; other site 644651003966 conserved gate region; other site 644651003967 putative PBP binding loops; other site 644651003968 ABC-ATPase subunit interface; other site 644651003969 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 644651003970 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644651003971 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 644651003972 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644651003973 inhibitor-cofactor binding pocket; inhibition site 644651003974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651003975 catalytic residue [active] 644651003976 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 644651003977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651003978 DNA-binding site [nucleotide binding]; DNA binding site 644651003979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651003980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651003981 homodimer interface [polypeptide binding]; other site 644651003982 catalytic residue [active] 644651003983 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 644651003984 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 644651003985 Walker A/P-loop; other site 644651003986 ATP binding site [chemical binding]; other site 644651003987 Q-loop/lid; other site 644651003988 ABC transporter signature motif; other site 644651003989 Walker B; other site 644651003990 D-loop; other site 644651003991 H-loop/switch region; other site 644651003992 TOBE domain; Region: TOBE_2; pfam08402 644651003993 phosphate acetyltransferase; Reviewed; Region: PRK05632 644651003994 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 644651003995 DRTGG domain; Region: DRTGG; pfam07085 644651003996 phosphate acetyltransferase; Region: pta; TIGR00651 644651003997 propionate/acetate kinase; Provisional; Region: PRK12379 644651003998 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 644651003999 hypothetical protein; Provisional; Region: PRK01816 644651004000 putative phosphatase; Provisional; Region: PRK11587 644651004001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651004002 motif II; other site 644651004003 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 644651004004 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 644651004005 active site 644651004006 conformational flexibility of ligand binding pocket; other site 644651004007 ADP-ribosylating toxin turn-turn motif; other site 644651004008 5'-nucleotidase; Provisional; Region: PRK03826 644651004009 aminotransferase AlaT; Validated; Region: PRK09265 644651004010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651004011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651004012 homodimer interface [polypeptide binding]; other site 644651004013 catalytic residue [active] 644651004014 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 644651004015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651004016 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 644651004017 putative dimerization interface [polypeptide binding]; other site 644651004018 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 644651004019 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 644651004020 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 644651004021 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 644651004022 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 644651004023 NADH dehydrogenase subunit E; Validated; Region: PRK07539 644651004024 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 644651004025 putative dimer interface [polypeptide binding]; other site 644651004026 [2Fe-2S] cluster binding site [ion binding]; other site 644651004027 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 644651004028 SLBB domain; Region: SLBB; pfam10531 644651004029 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 644651004030 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 644651004031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644651004032 catalytic loop [active] 644651004033 iron binding site [ion binding]; other site 644651004034 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 644651004035 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 644651004036 [4Fe-4S] binding site [ion binding]; other site 644651004037 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 644651004038 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 644651004039 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 644651004040 4Fe-4S binding domain; Region: Fer4; pfam00037 644651004041 4Fe-4S binding domain; Region: Fer4; pfam00037 644651004042 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 644651004043 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 644651004044 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 644651004045 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 644651004046 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 644651004047 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644651004048 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 644651004049 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644651004050 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 644651004051 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644651004052 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 644651004053 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 644651004054 hypothetical protein; Provisional; Region: PRK10404 644651004055 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 644651004056 potassium uptake protein; Region: kup; TIGR00794 644651004057 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 644651004058 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 644651004059 active site 644651004060 homotetramer interface [polypeptide binding]; other site 644651004061 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 644651004062 putative catalytic site [active] 644651004063 putative metal binding site [ion binding]; other site 644651004064 putative phosphate binding site [ion binding]; other site 644651004065 hypothetical protein; Provisional; Region: PRK03673 644651004066 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 644651004067 putative MPT binding site; other site 644651004068 Competence-damaged protein; Region: CinA; cl00666 644651004069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644651004070 catalytic loop [active] 644651004071 iron binding site [ion binding]; other site 644651004072 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 644651004073 dimer interface [polypeptide binding]; other site 644651004074 putative radical transfer pathway; other site 644651004075 diiron center [ion binding]; other site 644651004076 tyrosyl radical; other site 644651004077 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 644651004078 Class I ribonucleotide reductase; Region: RNR_I; cd01679 644651004079 active site 644651004080 dimer interface [polypeptide binding]; other site 644651004081 catalytic residues [active] 644651004082 effector binding site; other site 644651004083 R2 peptide binding site; other site 644651004084 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 644651004085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651004086 S-adenosylmethionine binding site [chemical binding]; other site 644651004087 DNA gyrase subunit A; Validated; Region: PRK05560 644651004088 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 644651004089 CAP-like domain; other site 644651004090 active site 644651004091 primary dimer interface [polypeptide binding]; other site 644651004092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644651004093 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644651004094 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644651004095 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644651004096 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644651004097 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644651004098 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 644651004099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651004100 dimer interface [polypeptide binding]; other site 644651004101 phosphorylation site [posttranslational modification] 644651004102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651004103 ATP binding site [chemical binding]; other site 644651004104 Mg2+ binding site [ion binding]; other site 644651004105 G-X-G motif; other site 644651004106 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 644651004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651004108 active site 644651004109 phosphorylation site [posttranslational modification] 644651004110 intermolecular recognition site; other site 644651004111 dimerization interface [polypeptide binding]; other site 644651004112 transcriptional regulator RcsB; Provisional; Region: PRK10840 644651004113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651004114 active site 644651004115 phosphorylation site [posttranslational modification] 644651004116 intermolecular recognition site; other site 644651004117 dimerization interface [polypeptide binding]; other site 644651004118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651004119 DNA binding residues [nucleotide binding] 644651004120 dimerization interface [polypeptide binding]; other site 644651004121 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 644651004122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651004123 ATP binding site [chemical binding]; other site 644651004124 Mg2+ binding site [ion binding]; other site 644651004125 G-X-G motif; other site 644651004126 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 644651004127 putative binding surface; other site 644651004128 active site 644651004129 potential protein location (hypothetical protein) that overlaps protein (MFS-type transporter YPO1221/y2967/YP_0917) 644651004130 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 644651004131 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 644651004132 trimer interface [polypeptide binding]; other site 644651004133 eyelet of channel; other site 644651004134 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 644651004135 ApbE family; Region: ApbE; pfam02424 644651004136 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 644651004137 potential frameshift: common BLAST hit: gi|385788857|ref|YP_005819966.1| multidrug transporter membrane protein/ATP-binding component 644651004138 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 644651004139 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644651004140 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 644651004141 Walker A/P-loop; other site 644651004142 ATP binding site [chemical binding]; other site 644651004143 Q-loop/lid; other site 644651004144 ABC transporter signature motif; other site 644651004145 Walker B; other site 644651004146 D-loop; other site 644651004147 H-loop/switch region; other site 644651004148 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644651004149 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644651004150 Walker A/P-loop; other site 644651004151 ATP binding site [chemical binding]; other site 644651004152 Q-loop/lid; other site 644651004153 ABC transporter signature motif; other site 644651004154 Walker B; other site 644651004155 D-loop; other site 644651004156 H-loop/switch region; other site 644651004157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651004158 dimer interface [polypeptide binding]; other site 644651004159 conserved gate region; other site 644651004160 putative PBP binding loops; other site 644651004161 ABC-ATPase subunit interface; other site 644651004162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651004163 Coenzyme A binding pocket [chemical binding]; other site 644651004164 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644651004165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651004166 substrate binding pocket [chemical binding]; other site 644651004167 membrane-bound complex binding site; other site 644651004168 hinge residues; other site 644651004169 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 644651004170 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 644651004171 metal binding site [ion binding]; metal-binding site 644651004172 dimer interface [polypeptide binding]; other site 644651004173 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 644651004174 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 644651004175 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 644651004176 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 644651004177 C2 domain; Region: C2; cl14603 644651004178 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 644651004179 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 644651004180 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 644651004181 Integrase core domain; Region: rve; pfam00665 644651004182 Integrase core domain; Region: rve_3; pfam13683 644651004183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651004184 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 644651004185 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 644651004186 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 644651004187 Sulfatase; Region: Sulfatase; cl17466 644651004188 hypothetical protein; Provisional; Region: PRK13689 644651004189 Nucleoid-associated protein [General function prediction only]; Region: COG3081 644651004190 nucleoid-associated protein NdpA; Validated; Region: PRK00378 644651004191 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 644651004192 5S rRNA interface [nucleotide binding]; other site 644651004193 CTC domain interface [polypeptide binding]; other site 644651004194 L16 interface [polypeptide binding]; other site 644651004195 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 644651004196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651004197 ATP binding site [chemical binding]; other site 644651004198 putative Mg++ binding site [ion binding]; other site 644651004199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651004200 nucleotide binding region [chemical binding]; other site 644651004201 ATP-binding site [chemical binding]; other site 644651004202 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 644651004203 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651004204 RNA binding surface [nucleotide binding]; other site 644651004205 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 644651004206 active site 644651004207 uracil binding [chemical binding]; other site 644651004208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651004209 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 644651004210 putative substrate translocation pore; other site 644651004211 hypothetical protein; Provisional; Region: PRK11835 644651004212 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 644651004213 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651004214 Walker A/P-loop; other site 644651004215 ATP binding site [chemical binding]; other site 644651004216 Q-loop/lid; other site 644651004217 ABC transporter signature motif; other site 644651004218 Walker B; other site 644651004219 D-loop; other site 644651004220 H-loop/switch region; other site 644651004221 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644651004222 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651004223 Walker A/P-loop; other site 644651004224 ATP binding site [chemical binding]; other site 644651004225 Q-loop/lid; other site 644651004226 ABC transporter signature motif; other site 644651004227 Walker B; other site 644651004228 D-loop; other site 644651004229 H-loop/switch region; other site 644651004230 microcin C ABC transporter permease; Provisional; Region: PRK15021 644651004231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651004232 dimer interface [polypeptide binding]; other site 644651004233 conserved gate region; other site 644651004234 ABC-ATPase subunit interface; other site 644651004235 potential frameshift: common BLAST hit: gi|259907992|ref|YP_002648348.1| ABC transporter transmembrane subunit 644651004236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651004237 dimer interface [polypeptide binding]; other site 644651004238 conserved gate region; other site 644651004239 putative PBP binding loops; other site 644651004240 ABC-ATPase subunit interface; other site 644651004241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644651004242 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644651004243 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 644651004244 phage resistance protein; Provisional; Region: PRK10551 644651004245 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 644651004246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644651004247 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 644651004248 NlpC/P60 family; Region: NLPC_P60; pfam00877 644651004249 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 644651004250 elongation factor P; Provisional; Region: PRK04542 644651004251 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 644651004252 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 644651004253 RNA binding site [nucleotide binding]; other site 644651004254 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 644651004255 RNA binding site [nucleotide binding]; other site 644651004256 Flagellin N-methylase; Region: FliB; cl00497 644651004257 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 644651004258 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644651004259 active site 644651004260 phosphorylation site [posttranslational modification] 644651004261 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 644651004262 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 644651004263 dimerization domain swap beta strand [polypeptide binding]; other site 644651004264 regulatory protein interface [polypeptide binding]; other site 644651004265 active site 644651004266 regulatory phosphorylation site [posttranslational modification]; other site 644651004267 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 644651004268 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 644651004269 putative substrate binding site [chemical binding]; other site 644651004270 putative ATP binding site [chemical binding]; other site 644651004271 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 644651004272 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 644651004273 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 644651004274 active site 644651004275 P-loop; other site 644651004276 phosphorylation site [posttranslational modification] 644651004277 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 644651004278 endonuclease IV; Provisional; Region: PRK01060 644651004279 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 644651004280 AP (apurinic/apyrimidinic) site pocket; other site 644651004281 DNA interaction; other site 644651004282 Metal-binding active site; metal-binding site 644651004283 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 644651004284 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 644651004285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651004286 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 644651004287 putative dimerization interface [polypeptide binding]; other site 644651004288 lysine transporter; Provisional; Region: PRK10836 644651004289 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 644651004290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644651004291 ABC-ATPase subunit interface; other site 644651004292 dimer interface [polypeptide binding]; other site 644651004293 putative PBP binding regions; other site 644651004294 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 644651004295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644651004296 Walker A/P-loop; other site 644651004297 ATP binding site [chemical binding]; other site 644651004298 Q-loop/lid; other site 644651004299 ABC transporter signature motif; other site 644651004300 Walker B; other site 644651004301 D-loop; other site 644651004302 H-loop/switch region; other site 644651004303 S-formylglutathione hydrolase; Region: PLN02442 644651004304 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 644651004305 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 644651004306 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 644651004307 substrate binding site [chemical binding]; other site 644651004308 catalytic Zn binding site [ion binding]; other site 644651004309 NAD binding site [chemical binding]; other site 644651004310 structural Zn binding site [ion binding]; other site 644651004311 dimer interface [polypeptide binding]; other site 644651004312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651004313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651004314 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 644651004315 putative dimerization interface [polypeptide binding]; other site 644651004316 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 644651004317 homodecamer interface [polypeptide binding]; other site 644651004318 GTP cyclohydrolase I; Provisional; Region: PLN03044 644651004319 active site 644651004320 putative catalytic site residues [active] 644651004321 zinc binding site [ion binding]; other site 644651004322 GTP-CH-I/GFRP interaction surface; other site 644651004323 Predicted membrane protein [Function unknown]; Region: COG2311 644651004324 hypothetical protein; Provisional; Region: PRK10835 644651004325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651004326 DNA binding site [nucleotide binding] 644651004327 domain linker motif; other site 644651004328 potential frameshift: common BLAST hit: gi|292899911|ref|YP_003539280.1| galactoside ABC transporter ATP-binding protein 644651004329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651004330 Walker B; other site 644651004331 D-loop; other site 644651004332 potential frameshift: common BLAST hit: gi|188533434|ref|YP_001907231.1| galactose/methyl galaxtoside transporter ATP-binding protein 644651004333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651004334 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 644651004335 potential frameshift: common BLAST hit: gi|292899911|ref|YP_003539280.1| galactoside ABC transporter ATP-binding protein 644651004336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651004337 ABC transporter signature motif; other site 644651004338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651004339 Walker B; other site 644651004340 D-loop; other site 644651004341 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 644651004342 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 644651004343 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 644651004344 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644651004345 TM-ABC transporter signature motif; other site 644651004346 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 644651004347 putative active site [active] 644651004348 malate dehydrogenase; Provisional; Region: PRK13529 644651004349 Malic enzyme, N-terminal domain; Region: malic; pfam00390 644651004350 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 644651004351 NAD(P) binding site [chemical binding]; other site 644651004352 cytidine deaminase; Provisional; Region: PRK09027 644651004353 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 644651004354 active site 644651004355 catalytic motif [active] 644651004356 Zn binding site [ion binding]; other site 644651004357 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 644651004358 hypothetical protein; Provisional; Region: PRK10711 644651004359 hypothetical protein; Provisional; Region: PRK01821 644651004360 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 644651004361 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 644651004362 active site 644651004363 HIGH motif; other site 644651004364 KMSKS motif; other site 644651004365 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 644651004366 tRNA binding surface [nucleotide binding]; other site 644651004367 anticodon binding site; other site 644651004368 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 644651004369 dimer interface [polypeptide binding]; other site 644651004370 putative tRNA-binding site [nucleotide binding]; other site 644651004371 antiporter inner membrane protein; Provisional; Region: PRK11670 644651004372 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 644651004373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 644651004374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651004375 Coenzyme A binding pocket [chemical binding]; other site 644651004376 chorismate mutase; Provisional; Region: PRK08055 644651004377 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 644651004378 substrate binding site [chemical binding]; other site 644651004379 multimerization interface [polypeptide binding]; other site 644651004380 ATP binding site [chemical binding]; other site 644651004381 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 644651004382 dimer interface [polypeptide binding]; other site 644651004383 substrate binding site [chemical binding]; other site 644651004384 ATP binding site [chemical binding]; other site 644651004385 lipid kinase; Reviewed; Region: PRK13054 644651004386 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 644651004387 Tir chaperone protein (CesT) family; Region: CesT; cl08444 644651004388 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 644651004389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651004390 active site 644651004391 phosphorylation site [posttranslational modification] 644651004392 intermolecular recognition site; other site 644651004393 dimerization interface [polypeptide binding]; other site 644651004394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651004395 DNA binding site [nucleotide binding] 644651004396 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 644651004397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651004398 dimerization interface [polypeptide binding]; other site 644651004399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651004400 dimer interface [polypeptide binding]; other site 644651004401 phosphorylation site [posttranslational modification] 644651004402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651004403 ATP binding site [chemical binding]; other site 644651004404 Mg2+ binding site [ion binding]; other site 644651004405 G-X-G motif; other site 644651004406 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 644651004407 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 644651004408 Protein export membrane protein; Region: SecD_SecF; cl14618 644651004409 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 644651004410 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 644651004411 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651004412 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644651004413 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644651004414 active site 644651004415 catalytic tetrad [active] 644651004416 putative chaperone; Provisional; Region: PRK11678 644651004417 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 644651004418 nucleotide binding site [chemical binding]; other site 644651004419 putative NEF/HSP70 interaction site [polypeptide binding]; other site 644651004420 SBD interface [polypeptide binding]; other site 644651004421 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 644651004422 active site 644651004423 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 644651004424 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 644651004425 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 644651004426 ATP-binding site [chemical binding]; other site 644651004427 Sugar specificity; other site 644651004428 Pyrimidine base specificity; other site 644651004429 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 644651004430 trimer interface [polypeptide binding]; other site 644651004431 active site 644651004432 putative assembly protein; Provisional; Region: PRK10833 644651004433 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 644651004434 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 644651004435 FOG: CBS domain [General function prediction only]; Region: COG0517 644651004436 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644651004437 Transporter associated domain; Region: CorC_HlyC; smart01091 644651004438 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 644651004439 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 644651004440 Bacterial sugar transferase; Region: Bac_transf; pfam02397 644651004441 polysaccharide export protein Wza; Provisional; Region: PRK15078 644651004442 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 644651004443 SLBB domain; Region: SLBB; pfam10531 644651004444 Low molecular weight phosphatase family; Region: LMWPc; cd00115 644651004445 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 644651004446 active site 644651004447 tyrosine kinase; Provisional; Region: PRK11519 644651004448 Chain length determinant protein; Region: Wzz; pfam02706 644651004449 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 644651004450 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 644651004451 P loop; other site 644651004452 Nucleotide binding site [chemical binding]; other site 644651004453 DTAP/Switch II; other site 644651004454 Switch I; other site 644651004455 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 644651004456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 644651004457 active site 644651004458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644651004459 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 644651004460 putative ADP-binding pocket [chemical binding]; other site 644651004461 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 644651004462 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 644651004463 Head binding; Region: Head_binding; pfam09008 644651004464 colanic acid biosynthesis protein; Provisional; Region: PRK10017 644651004465 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 644651004466 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 644651004467 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 644651004468 putative ADP-binding pocket [chemical binding]; other site 644651004469 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 644651004470 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 644651004471 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 644651004472 active site 644651004473 tetramer interface; other site 644651004474 UDP-glucose 4-epimerase; Region: PLN02240 644651004475 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 644651004476 NAD binding site [chemical binding]; other site 644651004477 homodimer interface [polypeptide binding]; other site 644651004478 active site 644651004479 substrate binding site [chemical binding]; other site 644651004480 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 644651004481 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 644651004482 NAD binding site [chemical binding]; other site 644651004483 substrate binding site [chemical binding]; other site 644651004484 homodimer interface [polypeptide binding]; other site 644651004485 active site 644651004486 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 644651004487 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 644651004488 substrate binding site; other site 644651004489 tetramer interface; other site 644651004490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651004491 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644651004492 NAD(P) binding site [chemical binding]; other site 644651004493 active site 644651004494 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 644651004495 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 644651004496 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 644651004497 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 644651004498 Walker A/P-loop; other site 644651004499 ATP binding site [chemical binding]; other site 644651004500 Q-loop/lid; other site 644651004501 ABC transporter signature motif; other site 644651004502 Walker B; other site 644651004503 D-loop; other site 644651004504 H-loop/switch region; other site 644651004505 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 644651004506 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 644651004507 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 644651004508 Ligand binding site; other site 644651004509 metal-binding site 644651004510 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 644651004511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 644651004512 UDP-galactopyranose mutase; Region: GLF; pfam03275 644651004513 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 644651004514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644651004515 active site 644651004516 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 644651004517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644651004518 putative ADP-binding pocket [chemical binding]; other site 644651004519 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 644651004520 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 644651004521 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 644651004522 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 644651004523 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 644651004524 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 644651004525 active site 644651004526 Zn binding site [ion binding]; other site 644651004527 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 644651004528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651004529 substrate binding pocket [chemical binding]; other site 644651004530 membrane-bound complex binding site; other site 644651004531 hinge residues; other site 644651004532 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 644651004533 putative deacylase active site [active] 644651004534 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 644651004535 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 644651004536 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 644651004537 metal binding site [ion binding]; metal-binding site 644651004538 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 644651004539 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 644651004540 substrate binding site [chemical binding]; other site 644651004541 glutamase interaction surface [polypeptide binding]; other site 644651004542 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 644651004543 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 644651004544 catalytic residues [active] 644651004545 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 644651004546 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 644651004547 putative active site [active] 644651004548 oxyanion strand; other site 644651004549 catalytic triad [active] 644651004550 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 644651004551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651004552 active site 644651004553 motif I; other site 644651004554 motif II; other site 644651004555 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 644651004556 putative active site pocket [active] 644651004557 4-fold oligomerization interface [polypeptide binding]; other site 644651004558 metal binding residues [ion binding]; metal-binding site 644651004559 3-fold/trimer interface [polypeptide binding]; other site 644651004560 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 644651004561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651004562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651004563 homodimer interface [polypeptide binding]; other site 644651004564 catalytic residue [active] 644651004565 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 644651004566 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 644651004567 NAD binding site [chemical binding]; other site 644651004568 dimerization interface [polypeptide binding]; other site 644651004569 product binding site; other site 644651004570 substrate binding site [chemical binding]; other site 644651004571 zinc binding site [ion binding]; other site 644651004572 catalytic residues [active] 644651004573 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 644651004574 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 644651004575 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 644651004576 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644651004577 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 644651004578 putative NAD(P) binding site [chemical binding]; other site 644651004579 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 644651004580 exonuclease I; Provisional; Region: sbcB; PRK11779 644651004581 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 644651004582 active site 644651004583 catalytic site [active] 644651004584 substrate binding site [chemical binding]; other site 644651004585 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 644651004586 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 644651004587 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 644651004588 Predicted membrane protein [Function unknown]; Region: COG1289 644651004589 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 644651004590 hypothetical protein; Provisional; Region: PRK05423 644651004591 MATE family multidrug exporter; Provisional; Region: PRK10189 644651004592 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 644651004593 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 644651004594 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 644651004595 active site 644651004596 FMN binding site [chemical binding]; other site 644651004597 substrate binding site [chemical binding]; other site 644651004598 homotetramer interface [polypeptide binding]; other site 644651004599 catalytic residue [active] 644651004600 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 644651004601 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 644651004602 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 644651004603 Uncharacterized conserved protein [Function unknown]; Region: COG2128 644651004604 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 644651004605 Prephenate dehydratase; Region: PDT; pfam00800 644651004606 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 644651004607 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 644651004608 homodimer interface [polypeptide binding]; other site 644651004609 substrate-cofactor binding pocket; other site 644651004610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651004611 catalytic residue [active] 644651004612 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 644651004613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644651004614 acyl-activating enzyme (AAE) consensus motif; other site 644651004615 AMP binding site [chemical binding]; other site 644651004616 active site 644651004617 CoA binding site [chemical binding]; other site 644651004618 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 644651004619 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 644651004620 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 644651004621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644651004622 putative DNA binding site [nucleotide binding]; other site 644651004623 dimerization interface [polypeptide binding]; other site 644651004624 putative Zn2+ binding site [ion binding]; other site 644651004625 AsnC family; Region: AsnC_trans_reg; pfam01037 644651004626 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 644651004627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651004628 Walker A motif; other site 644651004629 ATP binding site [chemical binding]; other site 644651004630 Walker B motif; other site 644651004631 arginine finger; other site 644651004632 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644651004633 DNA-binding interface [nucleotide binding]; DNA binding site 644651004634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644651004635 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 644651004636 putative NAD(P) binding site [chemical binding]; other site 644651004637 catalytic Zn binding site [ion binding]; other site 644651004638 AMP nucleosidase; Provisional; Region: PRK08292 644651004639 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 644651004640 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 644651004641 Predicted membrane protein [Function unknown]; Region: COG2323 644651004642 Transposase; Region: HTH_Tnp_1; cl17663 644651004643 Integrase core domain; Region: rve; pfam00665 644651004644 Integrase core domain; Region: rve_2; pfam13333 644651004645 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 644651004646 DEAD/DEAH box helicase; Region: DEAD; pfam00270 644651004647 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 644651004648 nucleotide binding region [chemical binding]; other site 644651004649 ATP-binding site [chemical binding]; other site 644651004650 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 644651004651 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 644651004652 putative transposase OrfB; Reviewed; Region: PHA02517 644651004653 HTH-like domain; Region: HTH_21; pfam13276 644651004654 Integrase core domain; Region: rve; pfam00665 644651004655 Integrase core domain; Region: rve_2; pfam13333 644651004656 Transposase; Region: HTH_Tnp_1; cl17663 644651004657 integrase; Provisional; Region: PRK09692 644651004658 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 644651004659 active site 644651004660 Int/Topo IB signature motif; other site 644651004661 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 644651004662 TM-ABC transporter signature motif; other site 644651004663 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651004664 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 644651004665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651004666 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 644651004667 putative dimerization interface [polypeptide binding]; other site 644651004668 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 644651004669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651004670 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 644651004671 substrate binding site [chemical binding]; other site 644651004672 dimerization interface [polypeptide binding]; other site 644651004673 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 644651004674 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 644651004675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651004676 Coenzyme A binding pocket [chemical binding]; other site 644651004677 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 644651004678 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 644651004679 putative ligand binding site [chemical binding]; other site 644651004680 NAD binding site [chemical binding]; other site 644651004681 dimerization interface [polypeptide binding]; other site 644651004682 catalytic site [active] 644651004683 potential frameshift: common BLAST hit: gi|300717400|ref|YP_003742203.1| AsnC family transcriptional regulator 644651004684 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 644651004685 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 644651004686 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 644651004687 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 644651004688 substrate binding site; other site 644651004689 Manganese binding site; other site 644651004690 dimer interface; other site 644651004691 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 644651004692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651004693 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644651004694 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 644651004695 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644651004696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644651004697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651004698 dimer interface [polypeptide binding]; other site 644651004699 conserved gate region; other site 644651004700 putative PBP binding loops; other site 644651004701 ABC-ATPase subunit interface; other site 644651004702 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644651004703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651004704 dimer interface [polypeptide binding]; other site 644651004705 conserved gate region; other site 644651004706 putative PBP binding loops; other site 644651004707 ABC-ATPase subunit interface; other site 644651004708 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 644651004709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651004710 Walker A/P-loop; other site 644651004711 ATP binding site [chemical binding]; other site 644651004712 Q-loop/lid; other site 644651004713 ABC transporter signature motif; other site 644651004714 Walker B; other site 644651004715 D-loop; other site 644651004716 H-loop/switch region; other site 644651004717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644651004718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651004719 Walker A/P-loop; other site 644651004720 ATP binding site [chemical binding]; other site 644651004721 Q-loop/lid; other site 644651004722 ABC transporter signature motif; other site 644651004723 Walker B; other site 644651004724 D-loop; other site 644651004725 H-loop/switch region; other site 644651004726 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644651004727 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644651004728 ABC-ATPase subunit interface; other site 644651004729 dimer interface [polypeptide binding]; other site 644651004730 putative PBP binding regions; other site 644651004731 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644651004732 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644651004733 ABC-ATPase subunit interface; other site 644651004734 dimer interface [polypeptide binding]; other site 644651004735 putative PBP binding regions; other site 644651004736 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 644651004737 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644651004738 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 644651004739 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 644651004740 metal binding site [ion binding]; metal-binding site 644651004741 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 644651004742 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 644651004743 heme binding site [chemical binding]; other site 644651004744 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 644651004745 heme binding site [chemical binding]; other site 644651004746 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 644651004747 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 644651004748 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 644651004749 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644651004750 Zn2+ binding site [ion binding]; other site 644651004751 Mg2+ binding site [ion binding]; other site 644651004752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 644651004753 DNA cytosine methylase; Provisional; Region: PRK10458 644651004754 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 644651004755 cofactor binding site; other site 644651004756 DNA binding site [nucleotide binding] 644651004757 substrate interaction site [chemical binding]; other site 644651004758 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 644651004759 additional DNA contacts [nucleotide binding]; other site 644651004760 mismatch recognition site; other site 644651004761 active site 644651004762 zinc binding site [ion binding]; other site 644651004763 DNA intercalation site [nucleotide binding]; other site 644651004764 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 644651004765 EamA-like transporter family; Region: EamA; pfam00892 644651004766 hypothetical protein; Provisional; Region: PRK10062 644651004767 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 644651004768 lipoprotein; Provisional; Region: PRK10397 644651004769 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 644651004770 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 644651004771 active site 644651004772 Na/Ca binding site [ion binding]; other site 644651004773 catalytic site [active] 644651004774 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 644651004775 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 644651004776 flagellar protein FliS; Validated; Region: fliS; PRK05685 644651004777 flagellar capping protein; Reviewed; Region: fliD; PRK08032 644651004778 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 644651004779 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 644651004780 flagellin; Provisional; Region: PRK12802 644651004781 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 644651004782 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 644651004783 HNH endonuclease; Region: HNH_2; pfam13391 644651004784 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 644651004785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644651004786 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644651004787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644651004788 DNA binding residues [nucleotide binding] 644651004789 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 644651004790 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 644651004791 Predicted transcriptional regulator [Transcription]; Region: COG3905 644651004792 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 644651004793 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 644651004794 Glutamate binding site [chemical binding]; other site 644651004795 NAD binding site [chemical binding]; other site 644651004796 catalytic residues [active] 644651004797 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 644651004798 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 644651004799 Na binding site [ion binding]; other site 644651004800 FTR1 family protein; Region: TIGR00145 644651004801 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 644651004802 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 644651004803 Imelysin; Region: Peptidase_M75; pfam09375 644651004804 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 644651004805 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 644651004806 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 644651004807 hypothetical protein; Provisional; Region: PRK10536 644651004808 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 644651004809 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 644651004810 dimer interface [polypeptide binding]; other site 644651004811 FMN binding site [chemical binding]; other site 644651004812 NADPH bind site [chemical binding]; other site 644651004813 alkaline phosphatase; Provisional; Region: PRK10518 644651004814 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 644651004815 dimer interface [polypeptide binding]; other site 644651004816 active site 644651004817 POT family; Region: PTR2; cl17359 644651004818 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 644651004819 CcdB protein; Region: CcdB; cl03380 644651004820 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 644651004821 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 644651004822 EamA-like transporter family; Region: EamA; pfam00892 644651004823 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 644651004824 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 644651004825 NAD(P) binding site [chemical binding]; other site 644651004826 catalytic residues [active] 644651004827 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644651004828 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 644651004829 Na binding site [ion binding]; other site 644651004830 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 644651004831 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 644651004832 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 644651004833 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644651004834 Predicted flavoprotein [General function prediction only]; Region: COG0431 644651004835 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 644651004836 dimer interface [polypeptide binding]; other site 644651004837 active site 644651004838 Schiff base residues; other site 644651004839 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 644651004840 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 644651004841 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 644651004842 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 644651004843 active site 644651004844 DNA binding site [nucleotide binding] 644651004845 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 644651004846 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 644651004847 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 644651004848 Catalytic site [active] 644651004849 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 644651004850 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 644651004851 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 644651004852 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 644651004853 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 644651004854 active site 644651004855 homotetramer interface [polypeptide binding]; other site 644651004856 transcriptional activator FlhD; Provisional; Region: PRK02909 644651004857 transcriptional activator FlhC; Provisional; Region: PRK12722 644651004858 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 644651004859 flagellar motor protein MotA; Validated; Region: PRK09110 644651004860 flagellar motor protein MotB; Validated; Region: motB; PRK09041 644651004861 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 644651004862 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 644651004863 ligand binding site [chemical binding]; other site 644651004864 chemotaxis protein CheA; Provisional; Region: PRK10547 644651004865 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 644651004866 putative binding surface; other site 644651004867 active site 644651004868 CheY binding; Region: CheY-binding; pfam09078 644651004869 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 644651004870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651004871 ATP binding site [chemical binding]; other site 644651004872 Mg2+ binding site [ion binding]; other site 644651004873 G-X-G motif; other site 644651004874 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 644651004875 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 644651004876 putative CheA interaction surface; other site 644651004877 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 644651004878 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 644651004879 dimer interface [polypeptide binding]; other site 644651004880 ligand binding site [chemical binding]; other site 644651004881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651004882 dimerization interface [polypeptide binding]; other site 644651004883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651004884 dimer interface [polypeptide binding]; other site 644651004885 putative CheW interface [polypeptide binding]; other site 644651004886 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 644651004887 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 644651004888 dimer interface [polypeptide binding]; other site 644651004889 ligand binding site [chemical binding]; other site 644651004890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651004891 dimerization interface [polypeptide binding]; other site 644651004892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651004893 dimer interface [polypeptide binding]; other site 644651004894 putative CheW interface [polypeptide binding]; other site 644651004895 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 644651004896 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 644651004897 dimer interface [polypeptide binding]; other site 644651004898 ligand binding site [chemical binding]; other site 644651004899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651004900 dimerization interface [polypeptide binding]; other site 644651004901 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651004902 dimer interface [polypeptide binding]; other site 644651004903 putative CheW interface [polypeptide binding]; other site 644651004904 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 644651004905 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 644651004906 dimer interface [polypeptide binding]; other site 644651004907 ligand binding site [chemical binding]; other site 644651004908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651004909 dimerization interface [polypeptide binding]; other site 644651004910 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651004911 dimer interface [polypeptide binding]; other site 644651004912 putative CheW interface [polypeptide binding]; other site 644651004913 methyl-accepting protein IV; Provisional; Region: PRK09793 644651004914 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 644651004915 dimer interface [polypeptide binding]; other site 644651004916 ligand binding site [chemical binding]; other site 644651004917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651004918 dimerization interface [polypeptide binding]; other site 644651004919 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651004920 dimer interface [polypeptide binding]; other site 644651004921 putative CheW interface [polypeptide binding]; other site 644651004922 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 644651004923 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 644651004924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651004925 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 644651004926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651004927 active site 644651004928 phosphorylation site [posttranslational modification] 644651004929 intermolecular recognition site; other site 644651004930 dimerization interface [polypeptide binding]; other site 644651004931 CheB methylesterase; Region: CheB_methylest; pfam01339 644651004932 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 644651004933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651004934 active site 644651004935 phosphorylation site [posttranslational modification] 644651004936 intermolecular recognition site; other site 644651004937 dimerization interface [polypeptide binding]; other site 644651004938 chemotaxis regulator CheZ; Provisional; Region: PRK11166 644651004939 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 644651004940 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 644651004941 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 644651004942 FHIPEP family; Region: FHIPEP; pfam00771 644651004943 Flagellar protein FlhE; Region: FlhE; pfam06366 644651004944 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 644651004945 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 644651004946 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 644651004947 active site 644651004948 HIGH motif; other site 644651004949 KMSK motif region; other site 644651004950 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 644651004951 tRNA binding surface [nucleotide binding]; other site 644651004952 anticodon binding site; other site 644651004953 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 644651004954 putative metal binding site [ion binding]; other site 644651004955 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 644651004956 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651004957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651004958 homodimer interface [polypeptide binding]; other site 644651004959 catalytic residue [active] 644651004960 copper homeostasis protein CutC; Provisional; Region: PRK11572 644651004961 Methyltransferase domain; Region: Methyltransf_31; pfam13847 644651004962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651004963 S-adenosylmethionine binding site [chemical binding]; other site 644651004964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651004965 S-adenosylmethionine binding site [chemical binding]; other site 644651004966 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 644651004967 hypothetical protein; Provisional; Region: PRK10302 644651004968 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 644651004969 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 644651004970 dimer interface [polypeptide binding]; other site 644651004971 anticodon binding site; other site 644651004972 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 644651004973 homodimer interface [polypeptide binding]; other site 644651004974 motif 1; other site 644651004975 active site 644651004976 motif 2; other site 644651004977 GAD domain; Region: GAD; pfam02938 644651004978 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644651004979 active site 644651004980 motif 3; other site 644651004981 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 644651004982 nudix motif; other site 644651004983 hypothetical protein; Validated; Region: PRK00110 644651004984 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 644651004985 active site 644651004986 putative DNA-binding cleft [nucleotide binding]; other site 644651004987 dimer interface [polypeptide binding]; other site 644651004988 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 644651004989 RuvA N terminal domain; Region: RuvA_N; pfam01330 644651004990 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 644651004991 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 644651004992 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 644651004993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651004994 Walker A motif; other site 644651004995 ATP binding site [chemical binding]; other site 644651004996 Walker B motif; other site 644651004997 arginine finger; other site 644651004998 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 644651004999 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644651005000 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644651005001 ABC-ATPase subunit interface; other site 644651005002 dimer interface [polypeptide binding]; other site 644651005003 putative PBP binding regions; other site 644651005004 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 644651005005 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644651005006 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 644651005007 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 644651005008 metal binding site [ion binding]; metal-binding site 644651005009 putative peptidase; Provisional; Region: PRK11649 644651005010 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644651005011 Peptidase family M23; Region: Peptidase_M23; pfam01551 644651005012 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 644651005013 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 644651005014 putative acyl-acceptor binding pocket; other site 644651005015 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 644651005016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005017 putative substrate translocation pore; other site 644651005018 pyruvate kinase; Provisional; Region: PRK05826 644651005019 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 644651005020 domain interfaces; other site 644651005021 active site 644651005022 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 644651005023 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 644651005024 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 644651005025 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 644651005026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651005027 ATP-grasp domain; Region: ATP-grasp; pfam02222 644651005028 YebG protein; Region: YebG; pfam07130 644651005029 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 644651005030 protease 2; Provisional; Region: PRK10115 644651005031 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644651005032 exodeoxyribonuclease X; Provisional; Region: PRK07983 644651005033 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 644651005034 active site 644651005035 catalytic site [active] 644651005036 substrate binding site [chemical binding]; other site 644651005037 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 644651005038 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 644651005039 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 644651005040 Biofilm formation and stress response factor; Region: BsmA; pfam10014 644651005041 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 644651005042 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644651005043 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644651005044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651005045 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 644651005046 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 644651005047 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 644651005048 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 644651005049 mce related protein; Region: MCE; pfam02470 644651005050 mce related protein; Region: MCE; pfam02470 644651005051 mce related protein; Region: MCE; pfam02470 644651005052 mce related protein; Region: MCE; pfam02470 644651005053 mce related protein; Region: MCE; pfam02470 644651005054 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 644651005055 Paraquat-inducible protein A; Region: PqiA; pfam04403 644651005056 Paraquat-inducible protein A; Region: PqiA; pfam04403 644651005057 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 644651005058 GAF domain; Region: GAF_2; pfam13185 644651005059 ProP expression regulator; Provisional; Region: PRK04950 644651005060 ProQ/FINO family; Region: ProQ; pfam04352 644651005061 carboxy-terminal protease; Provisional; Region: PRK11186 644651005062 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 644651005063 protein binding site [polypeptide binding]; other site 644651005064 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 644651005065 Catalytic dyad [active] 644651005066 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 644651005067 heat shock protein HtpX; Provisional; Region: PRK05457 644651005068 YobH-like protein; Region: YobH; pfam13996 644651005069 YebO-like protein; Region: YebO; pfam13974 644651005070 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 644651005071 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 644651005072 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644651005073 DNA-binding site [nucleotide binding]; DNA binding site 644651005074 RNA-binding motif; other site 644651005075 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 644651005076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651005077 S-adenosylmethionine binding site [chemical binding]; other site 644651005078 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 644651005079 FOG: CBS domain [General function prediction only]; Region: COG0517 644651005080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644651005081 Transporter associated domain; Region: CorC_HlyC; smart01091 644651005082 L-serine deaminase; Provisional; Region: PRK15023 644651005083 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 644651005084 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 644651005085 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 644651005086 putative active site [active] 644651005087 putative CoA binding site [chemical binding]; other site 644651005088 nudix motif; other site 644651005089 metal binding site [ion binding]; metal-binding site 644651005090 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 644651005091 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 644651005092 chorismate binding enzyme; Region: Chorismate_bind; cl10555 644651005093 hypothetical protein; Provisional; Region: PRK05114 644651005094 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 644651005095 homotrimer interaction site [polypeptide binding]; other site 644651005096 putative active site [active] 644651005097 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 644651005098 DEAD/DEAH box helicase; Region: DEAD; pfam00270 644651005099 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 644651005100 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 644651005101 Glycoprotease family; Region: Peptidase_M22; pfam00814 644651005102 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 644651005103 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 644651005104 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 644651005105 acyl-activating enzyme (AAE) consensus motif; other site 644651005106 putative AMP binding site [chemical binding]; other site 644651005107 putative active site [active] 644651005108 putative CoA binding site [chemical binding]; other site 644651005109 ribonuclease D; Provisional; Region: PRK10829 644651005110 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 644651005111 catalytic site [active] 644651005112 putative active site [active] 644651005113 putative substrate binding site [chemical binding]; other site 644651005114 HRDC domain; Region: HRDC; cl02578 644651005115 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 644651005116 cell division inhibitor MinD; Provisional; Region: PRK10818 644651005117 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 644651005118 Switch I; other site 644651005119 Switch II; other site 644651005120 septum formation inhibitor; Reviewed; Region: minC; PRK03511 644651005121 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 644651005122 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 644651005123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 644651005124 hypothetical protein; Provisional; Region: PRK10691 644651005125 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 644651005126 hypothetical protein; Provisional; Region: PRK05170 644651005127 disulfide bond formation protein B; Provisional; Region: PRK01749 644651005128 fatty acid metabolism regulator; Provisional; Region: PRK04984 644651005129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651005130 DNA-binding site [nucleotide binding]; DNA binding site 644651005131 FadR C-terminal domain; Region: FadR_C; pfam07840 644651005132 SpoVR family protein; Provisional; Region: PRK11767 644651005133 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 644651005134 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 644651005135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644651005136 hydroxyglutarate oxidase; Provisional; Region: PRK11728 644651005137 alanine racemase; Reviewed; Region: dadX; PRK03646 644651005138 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 644651005139 active site 644651005140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644651005141 substrate binding site [chemical binding]; other site 644651005142 catalytic residues [active] 644651005143 dimer interface [polypeptide binding]; other site 644651005144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005145 putative substrate translocation pore; other site 644651005146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644651005147 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 644651005148 Bacterial sugar transferase; Region: Bac_transf; pfam02397 644651005149 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 644651005150 TrkA-C domain; Region: TrkA_C; pfam02080 644651005151 Transporter associated domain; Region: CorC_HlyC; smart01091 644651005152 hypothetical protein; Provisional; Region: PRK05325 644651005153 PrkA family serine protein kinase; Provisional; Region: PRK15455 644651005154 AAA ATPase domain; Region: AAA_16; pfam13191 644651005155 Walker A motif; other site 644651005156 ATP binding site [chemical binding]; other site 644651005157 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 644651005158 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 644651005159 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644651005160 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 644651005161 active site 644651005162 phosphate binding residues; other site 644651005163 catalytic residues [active] 644651005164 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 644651005165 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 644651005166 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 644651005167 methionine sulfoxide reductase B; Provisional; Region: PRK00222 644651005168 SelR domain; Region: SelR; pfam01641 644651005169 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 644651005170 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 644651005171 Isochorismatase family; Region: Isochorismatase; pfam00857 644651005172 catalytic triad [active] 644651005173 metal binding site [ion binding]; metal-binding site 644651005174 conserved cis-peptide bond; other site 644651005175 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 644651005176 active site 644651005177 homodimer interface [polypeptide binding]; other site 644651005178 protease 4; Provisional; Region: PRK10949 644651005179 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 644651005180 tandem repeat interface [polypeptide binding]; other site 644651005181 oligomer interface [polypeptide binding]; other site 644651005182 active site residues [active] 644651005183 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 644651005184 tandem repeat interface [polypeptide binding]; other site 644651005185 oligomer interface [polypeptide binding]; other site 644651005186 active site residues [active] 644651005187 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 644651005188 putative FMN binding site [chemical binding]; other site 644651005189 DNA topoisomerase III; Provisional; Region: PRK07726 644651005190 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 644651005191 active site 644651005192 putative interdomain interaction site [polypeptide binding]; other site 644651005193 putative metal-binding site [ion binding]; other site 644651005194 putative nucleotide binding site [chemical binding]; other site 644651005195 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 644651005196 domain I; other site 644651005197 DNA binding groove [nucleotide binding] 644651005198 phosphate binding site [ion binding]; other site 644651005199 domain II; other site 644651005200 domain III; other site 644651005201 nucleotide binding site [chemical binding]; other site 644651005202 catalytic site [active] 644651005203 domain IV; other site 644651005204 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 644651005205 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 644651005206 putative catalytic site [active] 644651005207 putative phosphate binding site [ion binding]; other site 644651005208 active site 644651005209 metal binding site A [ion binding]; metal-binding site 644651005210 DNA binding site [nucleotide binding] 644651005211 putative AP binding site [nucleotide binding]; other site 644651005212 putative metal binding site B [ion binding]; other site 644651005213 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 644651005214 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 644651005215 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 644651005216 putative active site [active] 644651005217 putative substrate binding site [chemical binding]; other site 644651005218 putative cosubstrate binding site; other site 644651005219 catalytic site [active] 644651005220 SEC-C motif; Region: SEC-C; pfam02810 644651005221 hypothetical protein; Provisional; Region: PRK04233 644651005222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651005223 active site 644651005224 response regulator of RpoS; Provisional; Region: PRK10693 644651005225 phosphorylation site [posttranslational modification] 644651005226 intermolecular recognition site; other site 644651005227 dimerization interface [polypeptide binding]; other site 644651005228 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 644651005229 active site 644651005230 tetramer interface; other site 644651005231 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 644651005232 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 644651005233 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 644651005234 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 644651005235 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644651005236 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 644651005237 putative NAD(P) binding site [chemical binding]; other site 644651005238 active site 644651005239 putative substrate binding site [chemical binding]; other site 644651005240 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 644651005241 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 644651005242 thymidine kinase; Provisional; Region: PRK04296 644651005243 Cytochrome c; Region: Cytochrom_C; pfam00034 644651005244 hypothetical protein; Provisional; Region: PRK11111 644651005245 Homeodomain-like domain; Region: HTH_23; pfam13384 644651005246 Winged helix-turn helix; Region: HTH_29; pfam13551 644651005247 Homeodomain-like domain; Region: HTH_32; pfam13565 644651005248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651005249 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651005250 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 644651005251 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644651005252 peptide binding site [polypeptide binding]; other site 644651005253 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 644651005254 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644651005255 peptide binding site [polypeptide binding]; other site 644651005256 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 644651005257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651005258 dimer interface [polypeptide binding]; other site 644651005259 conserved gate region; other site 644651005260 putative PBP binding loops; other site 644651005261 ABC-ATPase subunit interface; other site 644651005262 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 644651005263 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644651005264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651005265 dimer interface [polypeptide binding]; other site 644651005266 conserved gate region; other site 644651005267 ABC-ATPase subunit interface; other site 644651005268 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 644651005269 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651005270 Walker A/P-loop; other site 644651005271 ATP binding site [chemical binding]; other site 644651005272 Q-loop/lid; other site 644651005273 ABC transporter signature motif; other site 644651005274 Walker B; other site 644651005275 D-loop; other site 644651005276 H-loop/switch region; other site 644651005277 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644651005278 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 644651005279 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651005280 Walker A/P-loop; other site 644651005281 ATP binding site [chemical binding]; other site 644651005282 Q-loop/lid; other site 644651005283 ABC transporter signature motif; other site 644651005284 Walker B; other site 644651005285 D-loop; other site 644651005286 H-loop/switch region; other site 644651005287 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 644651005288 dsDNA-mimic protein; Reviewed; Region: PRK05094 644651005289 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 644651005290 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 644651005291 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 644651005292 putative active site [active] 644651005293 catalytic site [active] 644651005294 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 644651005295 putative active site [active] 644651005296 catalytic site [active] 644651005297 YciI-like protein; Reviewed; Region: PRK11370 644651005298 transport protein TonB; Provisional; Region: PRK10819 644651005299 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 644651005300 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 644651005301 intracellular septation protein A; Reviewed; Region: PRK00259 644651005302 hypothetical protein; Provisional; Region: PRK02868 644651005303 outer membrane protein W; Provisional; Region: PRK10959 644651005304 BON domain; Region: BON; pfam04972 644651005305 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 644651005306 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 644651005307 substrate binding site [chemical binding]; other site 644651005308 active site 644651005309 catalytic residues [active] 644651005310 heterodimer interface [polypeptide binding]; other site 644651005311 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 644651005312 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 644651005313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651005314 catalytic residue [active] 644651005315 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 644651005316 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 644651005317 active site 644651005318 ribulose/triose binding site [chemical binding]; other site 644651005319 phosphate binding site [ion binding]; other site 644651005320 substrate (anthranilate) binding pocket [chemical binding]; other site 644651005321 product (indole) binding pocket [chemical binding]; other site 644651005322 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 644651005323 active site 644651005324 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 644651005325 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 644651005326 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 644651005327 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 644651005328 Glutamine amidotransferase class-I; Region: GATase; pfam00117 644651005329 glutamine binding [chemical binding]; other site 644651005330 catalytic triad [active] 644651005331 anthranilate synthase component I; Provisional; Region: PRK13564 644651005332 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 644651005333 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 644651005334 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 644651005335 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 644651005336 active site 644651005337 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 644651005338 hypothetical protein; Provisional; Region: PRK11630 644651005339 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 644651005340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651005341 RNA binding surface [nucleotide binding]; other site 644651005342 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 644651005343 probable active site [active] 644651005344 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 644651005345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651005346 NAD(P) binding site [chemical binding]; other site 644651005347 active site 644651005348 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 644651005349 putative inner membrane peptidase; Provisional; Region: PRK11778 644651005350 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 644651005351 tandem repeat interface [polypeptide binding]; other site 644651005352 oligomer interface [polypeptide binding]; other site 644651005353 active site residues [active] 644651005354 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 644651005355 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 644651005356 active site 644651005357 metal binding site [ion binding]; metal-binding site 644651005358 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 644651005359 domain I; other site 644651005360 DNA binding groove [nucleotide binding] 644651005361 phosphate binding site [ion binding]; other site 644651005362 domain II; other site 644651005363 domain III; other site 644651005364 nucleotide binding site [chemical binding]; other site 644651005365 catalytic site [active] 644651005366 domain IV; other site 644651005367 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644651005368 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644651005369 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 644651005370 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 644651005371 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 644651005372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651005373 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 644651005374 substrate binding site [chemical binding]; other site 644651005375 putative dimerization interface [polypeptide binding]; other site 644651005376 aconitate hydratase; Validated; Region: PRK09277 644651005377 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 644651005378 substrate binding site [chemical binding]; other site 644651005379 ligand binding site [chemical binding]; other site 644651005380 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 644651005381 substrate binding site [chemical binding]; other site 644651005382 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 644651005383 dimerization interface [polypeptide binding]; other site 644651005384 active site 644651005385 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 644651005386 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 644651005387 active site 644651005388 Predicted membrane protein [Function unknown]; Region: COG3771 644651005389 tetratricopeptide repeat protein; Provisional; Region: PRK11788 644651005390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 644651005391 TPR motif; other site 644651005392 binding surface 644651005393 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 644651005394 active site 644651005395 dimer interface [polypeptide binding]; other site 644651005396 translation initiation factor Sui1; Validated; Region: PRK06824 644651005397 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 644651005398 putative rRNA binding site [nucleotide binding]; other site 644651005399 lipoprotein; Provisional; Region: PRK10540 644651005400 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 644651005401 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 644651005402 intersubunit interface [polypeptide binding]; other site 644651005403 active site 644651005404 Zn2+ binding site [ion binding]; other site 644651005405 exoribonuclease II; Provisional; Region: PRK05054 644651005406 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 644651005407 RNB domain; Region: RNB; pfam00773 644651005408 S1 RNA binding domain; Region: S1; pfam00575 644651005409 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 644651005410 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 644651005411 putative molybdopterin cofactor binding site [chemical binding]; other site 644651005412 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 644651005413 putative molybdopterin cofactor binding site; other site 644651005414 PAAR motif; Region: PAAR_motif; pfam05488 644651005415 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 644651005416 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651005417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651005418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644651005419 dimerization interface [polypeptide binding]; other site 644651005420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 644651005421 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 644651005422 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 644651005423 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 644651005424 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651005425 Walker A/P-loop; other site 644651005426 ATP binding site [chemical binding]; other site 644651005427 Q-loop/lid; other site 644651005428 ABC transporter signature motif; other site 644651005429 Walker B; other site 644651005430 D-loop; other site 644651005431 H-loop/switch region; other site 644651005432 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 644651005433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651005434 Walker A/P-loop; other site 644651005435 ATP binding site [chemical binding]; other site 644651005436 Q-loop/lid; other site 644651005437 ABC transporter signature motif; other site 644651005438 Walker B; other site 644651005439 D-loop; other site 644651005440 H-loop/switch region; other site 644651005441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644651005442 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 644651005443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651005444 dimer interface [polypeptide binding]; other site 644651005445 conserved gate region; other site 644651005446 putative PBP binding loops; other site 644651005447 ABC-ATPase subunit interface; other site 644651005448 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 644651005449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651005450 dimer interface [polypeptide binding]; other site 644651005451 conserved gate region; other site 644651005452 putative PBP binding loops; other site 644651005453 ABC-ATPase subunit interface; other site 644651005454 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644651005455 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 644651005456 peptide binding site [polypeptide binding]; other site 644651005457 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 644651005458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651005459 Walker A motif; other site 644651005460 ATP binding site [chemical binding]; other site 644651005461 Walker B motif; other site 644651005462 arginine finger; other site 644651005463 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 644651005464 phage shock protein PspA; Provisional; Region: PRK10698 644651005465 phage shock protein B; Provisional; Region: pspB; PRK09458 644651005466 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 644651005467 phage shock protein C; Region: phageshock_pspC; TIGR02978 644651005468 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 644651005469 Predicted ATPase [General function prediction only]; Region: COG3106 644651005470 hypothetical protein; Provisional; Region: PRK05415 644651005471 Domain of unknown function (DUF697); Region: DUF697; cl12064 644651005472 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 644651005473 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 644651005474 putative aromatic amino acid binding site; other site 644651005475 PAS domain; Region: PAS; smart00091 644651005476 putative active site [active] 644651005477 heme pocket [chemical binding]; other site 644651005478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651005479 Walker A motif; other site 644651005480 ATP binding site [chemical binding]; other site 644651005481 Walker B motif; other site 644651005482 arginine finger; other site 644651005483 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 644651005484 dimer interface [polypeptide binding]; other site 644651005485 catalytic triad [active] 644651005486 peroxidatic and resolving cysteines [active] 644651005487 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 644651005488 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 644651005489 active site 644651005490 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 644651005491 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644651005492 peptide binding site [polypeptide binding]; other site 644651005493 AAA domain; Region: AAA_33; pfam13671 644651005494 hypothetical protein; Provisional; Region: PRK15301 644651005495 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 644651005496 PapC N-terminal domain; Region: PapC_N; pfam13954 644651005497 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 644651005498 PapC C-terminal domain; Region: PapC_C; pfam13953 644651005499 putative fimbrial chaperone protein; Provisional; Region: PRK09918 644651005500 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 644651005501 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 644651005502 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 644651005503 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 644651005504 Cl binding site [ion binding]; other site 644651005505 oligomer interface [polypeptide binding]; other site 644651005506 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644651005507 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644651005508 Ca binding site [ion binding]; other site 644651005509 active site 644651005510 catalytic site [active] 644651005511 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 644651005512 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 644651005513 Ligand Binding Site [chemical binding]; other site 644651005514 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 644651005515 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644651005516 ATP binding site [chemical binding]; other site 644651005517 Mg++ binding site [ion binding]; other site 644651005518 motif III; other site 644651005519 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651005520 nucleotide binding region [chemical binding]; other site 644651005521 ATP-binding site [chemical binding]; other site 644651005522 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 644651005523 putative RNA binding site [nucleotide binding]; other site 644651005524 Uncharacterized conserved protein [Function unknown]; Region: COG1359 644651005525 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 644651005526 Domain of unknown function (DUF333); Region: DUF333; pfam03891 644651005527 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 644651005528 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 644651005529 putative ligand binding site [chemical binding]; other site 644651005530 putative NAD binding site [chemical binding]; other site 644651005531 catalytic site [active] 644651005532 hypothetical protein; Provisional; Region: PRK10695 644651005533 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 644651005534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 644651005535 azoreductase; Reviewed; Region: PRK00170 644651005536 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644651005537 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 644651005538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651005539 ATP binding site [chemical binding]; other site 644651005540 putative Mg++ binding site [ion binding]; other site 644651005541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651005542 nucleotide binding region [chemical binding]; other site 644651005543 ATP-binding site [chemical binding]; other site 644651005544 Helicase associated domain (HA2); Region: HA2; pfam04408 644651005545 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 644651005546 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 644651005547 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 644651005548 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 644651005549 amidase catalytic site [active] 644651005550 Zn binding residues [ion binding]; other site 644651005551 substrate binding site [chemical binding]; other site 644651005552 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 644651005553 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 644651005554 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 644651005555 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 644651005556 active site 644651005557 Zn binding site [ion binding]; other site 644651005558 sensor protein RstB; Provisional; Region: PRK10604 644651005559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651005560 dimerization interface [polypeptide binding]; other site 644651005561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651005562 dimer interface [polypeptide binding]; other site 644651005563 phosphorylation site [posttranslational modification] 644651005564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651005565 ATP binding site [chemical binding]; other site 644651005566 Mg2+ binding site [ion binding]; other site 644651005567 G-X-G motif; other site 644651005568 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 644651005569 exonuclease VIII; Reviewed; Region: PRK09709 644651005570 transcriptional repressor DicA; Reviewed; Region: PRK09706 644651005571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651005572 non-specific DNA binding site [nucleotide binding]; other site 644651005573 salt bridge; other site 644651005574 sequence-specific DNA binding site [nucleotide binding]; other site 644651005575 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 644651005576 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 644651005577 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 644651005578 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 644651005579 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 644651005580 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 644651005581 Predicted chitinase [General function prediction only]; Region: COG3179 644651005582 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 644651005583 hypothetical protein; Region: PHA02310 644651005584 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 644651005585 Baseplate J-like protein; Region: Baseplate_J; cl01294 644651005586 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 644651005587 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644651005588 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 644651005589 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644651005590 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 644651005591 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 644651005592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651005593 active site 644651005594 phosphorylation site [posttranslational modification] 644651005595 intermolecular recognition site; other site 644651005596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651005597 DNA binding site [nucleotide binding] 644651005598 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 644651005599 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 644651005600 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 644651005601 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 644651005602 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 644651005603 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 644651005604 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 644651005605 N-terminal plug; other site 644651005606 ligand-binding site [chemical binding]; other site 644651005607 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 644651005608 universal stress protein UspE; Provisional; Region: PRK11175 644651005609 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644651005610 Ligand Binding Site [chemical binding]; other site 644651005611 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644651005612 Ligand Binding Site [chemical binding]; other site 644651005613 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 644651005614 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 644651005615 ligand binding site [chemical binding]; other site 644651005616 flexible hinge region; other site 644651005617 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 644651005618 putative switch regulator; other site 644651005619 non-specific DNA interactions [nucleotide binding]; other site 644651005620 DNA binding site [nucleotide binding] 644651005621 sequence specific DNA binding site [nucleotide binding]; other site 644651005622 putative cAMP binding site [chemical binding]; other site 644651005623 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 644651005624 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 644651005625 substrate binding [chemical binding]; other site 644651005626 active site 644651005627 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 644651005628 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 644651005629 Acyltransferase family; Region: Acyl_transf_3; pfam01757 644651005630 benzoate transport; Region: 2A0115; TIGR00895 644651005631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005632 putative substrate translocation pore; other site 644651005633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005634 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 644651005635 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 644651005636 substrate binding pocket [chemical binding]; other site 644651005637 catalytic triad [active] 644651005638 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 644651005639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651005640 dimerization interface [polypeptide binding]; other site 644651005641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651005642 dimer interface [polypeptide binding]; other site 644651005643 putative CheW interface [polypeptide binding]; other site 644651005644 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 644651005645 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 644651005646 metal binding site [ion binding]; metal-binding site 644651005647 dimer interface [polypeptide binding]; other site 644651005648 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644651005649 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 644651005650 peptide binding site [polypeptide binding]; other site 644651005651 putative arabinose transporter; Provisional; Region: PRK03545 644651005652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005653 putative substrate translocation pore; other site 644651005654 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 644651005655 glutaminase; Provisional; Region: PRK00971 644651005656 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 644651005657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651005658 Rrf2 family protein; Region: rrf2_super; TIGR00738 644651005659 Transcriptional regulator; Region: Rrf2; pfam02082 644651005660 Transcriptional regulator; Region: Rrf2; cl17282 644651005661 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644651005662 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644651005663 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 644651005664 active site 644651005665 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 644651005666 RNAase interaction site [polypeptide binding]; other site 644651005667 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 644651005668 Virulence factor SrfB; Region: SrfB; pfam07520 644651005669 malate:quinone oxidoreductase; Validated; Region: PRK05257 644651005670 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 644651005671 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 644651005672 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 644651005673 active site clefts [active] 644651005674 zinc binding site [ion binding]; other site 644651005675 dimer interface [polypeptide binding]; other site 644651005676 Nitrate and nitrite sensing; Region: NIT; pfam08376 644651005677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651005678 dimerization interface [polypeptide binding]; other site 644651005679 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 644651005680 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651005681 dimer interface [polypeptide binding]; other site 644651005682 putative CheW interface [polypeptide binding]; other site 644651005683 Helix-turn-helix domain; Region: HTH_28; pfam13518 644651005684 Winged helix-turn helix; Region: HTH_29; pfam13551 644651005685 Homeodomain-like domain; Region: HTH_32; pfam13565 644651005686 Fic/DOC family; Region: Fic; cl00960 644651005687 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 644651005688 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 644651005689 tetramer interface [polypeptide binding]; other site 644651005690 heme binding pocket [chemical binding]; other site 644651005691 NADPH binding site [chemical binding]; other site 644651005692 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 644651005693 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 644651005694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 644651005695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651005696 Coenzyme A binding pocket [chemical binding]; other site 644651005697 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 644651005698 active site 644651005699 catalytic site [active] 644651005700 putative metal binding site [ion binding]; other site 644651005701 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 644651005702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644651005703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651005704 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 644651005705 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 644651005706 Rdx family; Region: Rdx; cl01407 644651005707 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 644651005708 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 644651005709 N-terminal plug; other site 644651005710 ligand-binding site [chemical binding]; other site 644651005711 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 644651005712 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 644651005713 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 644651005714 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 644651005715 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 644651005716 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 644651005717 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 644651005718 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 644651005719 NAD(P) binding site [chemical binding]; other site 644651005720 Protein of unknown function (DUF441); Region: DUF441; cl01041 644651005721 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 644651005722 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 644651005723 salicylate hydroxylase; Provisional; Region: PRK08163 644651005724 hypothetical protein; Provisional; Region: PRK07236 644651005725 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 644651005726 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 644651005727 active site 644651005728 Zn binding site [ion binding]; other site 644651005729 guanine deaminase; Provisional; Region: PRK09228 644651005730 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 644651005731 active site 644651005732 malonic semialdehyde reductase; Provisional; Region: PRK10538 644651005733 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 644651005734 putative NAD(P) binding site [chemical binding]; other site 644651005735 homodimer interface [polypeptide binding]; other site 644651005736 homotetramer interface [polypeptide binding]; other site 644651005737 active site 644651005738 hypothetical protein; Provisional; Region: PRK13659 644651005739 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 644651005740 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644651005741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005742 putative substrate translocation pore; other site 644651005743 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 644651005744 AAA domain; Region: AAA_26; pfam13500 644651005745 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644651005746 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644651005747 nucleotide binding site [chemical binding]; other site 644651005748 potential protein location (hypothetical protein) that overlaps protein (Xylose repressor) 644651005749 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 644651005750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651005751 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 644651005752 dimerization interface [polypeptide binding]; other site 644651005753 substrate binding pocket [chemical binding]; other site 644651005754 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 644651005755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005756 putative substrate translocation pore; other site 644651005757 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 644651005758 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 644651005759 fumarate hydratase; Reviewed; Region: fumC; PRK00485 644651005760 Class II fumarases; Region: Fumarase_classII; cd01362 644651005761 active site 644651005762 tetramer interface [polypeptide binding]; other site 644651005763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 644651005764 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 644651005765 adenosine deaminase; Provisional; Region: PRK09358 644651005766 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 644651005767 active site 644651005768 putative oxidoreductase; Provisional; Region: PRK11579 644651005769 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644651005770 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 644651005771 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 644651005772 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 644651005773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651005774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651005775 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 644651005776 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644651005777 TM-ABC transporter signature motif; other site 644651005778 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 644651005779 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 644651005780 Walker A/P-loop; other site 644651005781 ATP binding site [chemical binding]; other site 644651005782 Q-loop/lid; other site 644651005783 ABC transporter signature motif; other site 644651005784 Walker B; other site 644651005785 D-loop; other site 644651005786 H-loop/switch region; other site 644651005787 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 644651005788 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 644651005789 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 644651005790 ligand binding site [chemical binding]; other site 644651005791 ribulokinase; Provisional; Region: PRK04123 644651005792 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 644651005793 N- and C-terminal domain interface [polypeptide binding]; other site 644651005794 active site 644651005795 MgATP binding site [chemical binding]; other site 644651005796 catalytic site [active] 644651005797 metal binding site [ion binding]; metal-binding site 644651005798 carbohydrate binding site [chemical binding]; other site 644651005799 homodimer interface [polypeptide binding]; other site 644651005800 L-arabinose isomerase; Provisional; Region: PRK02929 644651005801 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 644651005802 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 644651005803 trimer interface [polypeptide binding]; other site 644651005804 putative substrate binding site [chemical binding]; other site 644651005805 putative metal binding site [ion binding]; other site 644651005806 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 644651005807 electron transport complex protein RsxA; Provisional; Region: PRK05151 644651005808 electron transport complex protein RnfB; Provisional; Region: PRK05113 644651005809 Putative Fe-S cluster; Region: FeS; cl17515 644651005810 4Fe-4S binding domain; Region: Fer4; pfam00037 644651005811 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 644651005812 SLBB domain; Region: SLBB; pfam10531 644651005813 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 644651005814 electron transport complex protein RnfG; Validated; Region: PRK01908 644651005815 electron transport complex RsxE subunit; Provisional; Region: PRK12405 644651005816 endonuclease III; Provisional; Region: PRK10702 644651005817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644651005818 minor groove reading motif; other site 644651005819 helix-hairpin-helix signature motif; other site 644651005820 substrate binding pocket [chemical binding]; other site 644651005821 active site 644651005822 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 644651005823 choline dehydrogenase; Validated; Region: PRK02106 644651005824 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 644651005825 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 644651005826 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 644651005827 tetrameric interface [polypeptide binding]; other site 644651005828 NAD binding site [chemical binding]; other site 644651005829 catalytic residues [active] 644651005830 transcriptional regulator BetI; Validated; Region: PRK00767 644651005831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651005832 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 644651005833 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 644651005834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005835 putative substrate translocation pore; other site 644651005836 POT family; Region: PTR2; pfam00854 644651005837 glutathionine S-transferase; Provisional; Region: PRK10542 644651005838 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 644651005839 C-terminal domain interface [polypeptide binding]; other site 644651005840 GSH binding site (G-site) [chemical binding]; other site 644651005841 dimer interface [polypeptide binding]; other site 644651005842 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 644651005843 dimer interface [polypeptide binding]; other site 644651005844 N-terminal domain interface [polypeptide binding]; other site 644651005845 substrate binding pocket (H-site) [chemical binding]; other site 644651005846 pyridoxamine kinase; Validated; Region: PRK05756 644651005847 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 644651005848 dimer interface [polypeptide binding]; other site 644651005849 pyridoxal binding site [chemical binding]; other site 644651005850 ATP binding site [chemical binding]; other site 644651005851 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 644651005852 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 644651005853 active site 644651005854 HIGH motif; other site 644651005855 dimer interface [polypeptide binding]; other site 644651005856 KMSKS motif; other site 644651005857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651005858 RNA binding surface [nucleotide binding]; other site 644651005859 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 644651005860 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 644651005861 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 644651005862 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 644651005863 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 644651005864 transcriptional regulator SlyA; Provisional; Region: PRK03573 644651005865 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 644651005866 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 644651005867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651005868 MULE transposase domain; Region: MULE; pfam10551 644651005869 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 644651005870 putative metal dependent hydrolase; Provisional; Region: PRK11598 644651005871 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 644651005872 Sulfatase; Region: Sulfatase; pfam00884 644651005873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644651005874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651005875 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 644651005876 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 644651005877 FMN binding site [chemical binding]; other site 644651005878 active site 644651005879 substrate binding site [chemical binding]; other site 644651005880 catalytic residue [active] 644651005881 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 644651005882 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 644651005883 dimer interface [polypeptide binding]; other site 644651005884 active site 644651005885 metal binding site [ion binding]; metal-binding site 644651005886 glutathione binding site [chemical binding]; other site 644651005887 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 644651005888 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 644651005889 dimer interface [polypeptide binding]; other site 644651005890 catalytic site [active] 644651005891 putative active site [active] 644651005892 putative substrate binding site [chemical binding]; other site 644651005893 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 644651005894 putative GSH binding site [chemical binding]; other site 644651005895 catalytic residues [active] 644651005896 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 644651005897 NlpC/P60 family; Region: NLPC_P60; pfam00877 644651005898 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 644651005899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651005900 DNA binding site [nucleotide binding] 644651005901 domain linker motif; other site 644651005902 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 644651005903 dimerization interface [polypeptide binding]; other site 644651005904 ligand binding site [chemical binding]; other site 644651005905 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 644651005906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651005907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644651005908 dimerization interface [polypeptide binding]; other site 644651005909 putative transporter; Provisional; Region: PRK11043 644651005910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651005911 putative substrate translocation pore; other site 644651005912 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 644651005913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651005914 S-adenosylmethionine binding site [chemical binding]; other site 644651005915 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 644651005916 Lumazine binding domain; Region: Lum_binding; pfam00677 644651005917 Lumazine binding domain; Region: Lum_binding; pfam00677 644651005918 multidrug efflux protein; Reviewed; Region: PRK01766 644651005919 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 644651005920 cation binding site [ion binding]; other site 644651005921 pyruvate kinase; Provisional; Region: PRK09206 644651005922 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 644651005923 domain interfaces; other site 644651005924 active site 644651005925 murein lipoprotein; Provisional; Region: PRK15396 644651005926 cysteine desufuration protein SufE; Provisional; Region: PRK09296 644651005927 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 644651005928 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 644651005929 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651005930 catalytic residue [active] 644651005931 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 644651005932 FeS assembly protein SufD; Region: sufD; TIGR01981 644651005933 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 644651005934 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 644651005935 Walker A/P-loop; other site 644651005936 ATP binding site [chemical binding]; other site 644651005937 Q-loop/lid; other site 644651005938 ABC transporter signature motif; other site 644651005939 Walker B; other site 644651005940 D-loop; other site 644651005941 H-loop/switch region; other site 644651005942 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 644651005943 putative ABC transporter; Region: ycf24; CHL00085 644651005944 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 644651005945 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 644651005946 FAD binding domain; Region: FAD_binding_4; pfam01565 644651005947 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 644651005948 putative inner membrane protein; Provisional; Region: PRK10983 644651005949 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644651005950 phosphoenolpyruvate synthase; Validated; Region: PRK06464 644651005951 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 644651005952 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 644651005953 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 644651005954 PEP synthetase regulatory protein; Provisional; Region: PRK05339 644651005955 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 644651005956 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 644651005957 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 644651005958 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 644651005959 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 644651005960 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 644651005961 putative hemin binding site; other site 644651005962 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 644651005963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644651005964 ABC-ATPase subunit interface; other site 644651005965 dimer interface [polypeptide binding]; other site 644651005966 putative PBP binding regions; other site 644651005967 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 644651005968 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644651005969 Walker A/P-loop; other site 644651005970 ATP binding site [chemical binding]; other site 644651005971 Q-loop/lid; other site 644651005972 ABC transporter signature motif; other site 644651005973 Walker B; other site 644651005974 D-loop; other site 644651005975 H-loop/switch region; other site 644651005976 Uncharacterized conserved protein [Function unknown]; Region: COG0397 644651005977 hypothetical protein; Validated; Region: PRK00029 644651005978 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 644651005979 NlpC/P60 family; Region: NLPC_P60; pfam00877 644651005980 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 644651005981 catalytic residues [active] 644651005982 dimer interface [polypeptide binding]; other site 644651005983 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 644651005984 IHF dimer interface [polypeptide binding]; other site 644651005985 IHF - DNA interface [nucleotide binding]; other site 644651005986 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 644651005987 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 644651005988 putative tRNA-binding site [nucleotide binding]; other site 644651005989 B3/4 domain; Region: B3_4; pfam03483 644651005990 tRNA synthetase B5 domain; Region: B5; smart00874 644651005991 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 644651005992 dimer interface [polypeptide binding]; other site 644651005993 motif 1; other site 644651005994 motif 3; other site 644651005995 motif 2; other site 644651005996 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 644651005997 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 644651005998 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 644651005999 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 644651006000 dimer interface [polypeptide binding]; other site 644651006001 motif 1; other site 644651006002 active site 644651006003 motif 2; other site 644651006004 motif 3; other site 644651006005 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 644651006006 23S rRNA binding site [nucleotide binding]; other site 644651006007 L21 binding site [polypeptide binding]; other site 644651006008 L13 binding site [polypeptide binding]; other site 644651006009 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 644651006010 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 644651006011 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 644651006012 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 644651006013 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 644651006014 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 644651006015 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 644651006016 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 644651006017 active site 644651006018 dimer interface [polypeptide binding]; other site 644651006019 motif 1; other site 644651006020 motif 2; other site 644651006021 motif 3; other site 644651006022 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 644651006023 anticodon binding site; other site 644651006024 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644651006025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 644651006026 Protein of unknown function, DUF481; Region: DUF481; cl01213 644651006027 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 644651006028 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 644651006029 Phosphotransferase enzyme family; Region: APH; pfam01636 644651006030 YniB-like protein; Region: YniB; pfam14002 644651006031 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 644651006032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651006033 motif II; other site 644651006034 inner membrane protein; Provisional; Region: PRK11648 644651006035 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 644651006036 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 644651006037 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 644651006038 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 644651006039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651006040 putative substrate translocation pore; other site 644651006041 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 644651006042 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 644651006043 homodimer interface [polypeptide binding]; other site 644651006044 NAD binding pocket [chemical binding]; other site 644651006045 ATP binding pocket [chemical binding]; other site 644651006046 Mg binding site [ion binding]; other site 644651006047 active-site loop [active] 644651006048 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 644651006049 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 644651006050 GIY-YIG motif/motif A; other site 644651006051 active site 644651006052 catalytic site [active] 644651006053 putative DNA binding site [nucleotide binding]; other site 644651006054 metal binding site [ion binding]; metal-binding site 644651006055 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 644651006056 dimer interface [polypeptide binding]; other site 644651006057 succinylglutamate desuccinylase; Provisional; Region: PRK05324 644651006058 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 644651006059 active site 644651006060 Zn binding site [ion binding]; other site 644651006061 succinylarginine dihydrolase; Provisional; Region: PRK13281 644651006062 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 644651006063 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 644651006064 NAD(P) binding site [chemical binding]; other site 644651006065 catalytic residues [active] 644651006066 arginine succinyltransferase; Provisional; Region: PRK10456 644651006067 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 644651006068 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 644651006069 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644651006070 inhibitor-cofactor binding pocket; inhibition site 644651006071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651006072 catalytic residue [active] 644651006073 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 644651006074 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 644651006075 trimer interface [polypeptide binding]; other site 644651006076 eyelet of channel; other site 644651006077 putative invasin; Provisional; Region: PRK10177 644651006078 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 644651006079 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 644651006080 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 644651006081 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 644651006082 ligand binding site [chemical binding]; other site 644651006083 potential frameshift: common BLAST hit: gi|259908603|ref|YP_002648959.1| type VI secretion system, IcmF protein 644651006084 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 644651006085 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 644651006086 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 644651006087 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 644651006088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 644651006089 phosphopeptide binding site; other site 644651006090 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 644651006091 putative active site pocket [active] 644651006092 dimerization interface [polypeptide binding]; other site 644651006093 putative catalytic residue [active] 644651006094 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644651006095 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 644651006096 putative ATP binding site [chemical binding]; other site 644651006097 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 644651006098 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 644651006099 trimer interface; other site 644651006100 sugar binding site [chemical binding]; other site 644651006101 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 644651006102 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644651006103 active site turn [active] 644651006104 phosphorylation site [posttranslational modification] 644651006105 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644651006106 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 644651006107 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 644651006108 substrate binding [chemical binding]; other site 644651006109 active site 644651006110 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 644651006111 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 644651006112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651006113 DNA binding site [nucleotide binding] 644651006114 domain linker motif; other site 644651006115 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 644651006116 dimerization interface [polypeptide binding]; other site 644651006117 ligand binding site [chemical binding]; other site 644651006118 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 644651006119 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 644651006120 META domain; Region: META; cl01245 644651006121 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 644651006122 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 644651006123 hypothetical protein; Provisional; Region: PRK10941 644651006124 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 644651006125 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 644651006126 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 644651006127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651006128 S-adenosylmethionine binding site [chemical binding]; other site 644651006129 peptide chain release factor 1; Validated; Region: prfA; PRK00591 644651006130 This domain is found in peptide chain release factors; Region: PCRF; smart00937 644651006131 RF-1 domain; Region: RF-1; pfam00472 644651006132 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 644651006133 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 644651006134 tRNA; other site 644651006135 putative tRNA binding site [nucleotide binding]; other site 644651006136 putative NADP binding site [chemical binding]; other site 644651006137 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 644651006138 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 644651006139 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 644651006140 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 644651006141 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 644651006142 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 644651006143 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 644651006144 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651006145 active site 644651006146 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 644651006147 putative active site [active] 644651006148 catalytic residue [active] 644651006149 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 644651006150 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 644651006151 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 644651006152 Sulfate transporter family; Region: Sulfate_transp; pfam00916 644651006153 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 644651006154 GTP-binding protein YchF; Reviewed; Region: PRK09601 644651006155 YchF GTPase; Region: YchF; cd01900 644651006156 G1 box; other site 644651006157 GTP/Mg2+ binding site [chemical binding]; other site 644651006158 Switch I region; other site 644651006159 G2 box; other site 644651006160 Switch II region; other site 644651006161 G3 box; other site 644651006162 G4 box; other site 644651006163 G5 box; other site 644651006164 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 644651006165 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 644651006166 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 644651006167 chaperone protein SicA; Provisional; Region: PRK15331 644651006168 Tetratricopeptide repeat; Region: TPR_3; pfam07720 644651006169 Tetratricopeptide repeat; Region: TPR_3; pfam07720 644651006170 type III secretion system protein SpaS; Validated; Region: PRK08156 644651006171 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 644651006172 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 644651006173 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 644651006174 type III secretion system protein SpaO; Validated; Region: PRK08158 644651006175 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 644651006176 ATP synthase SpaL; Validated; Region: PRK08149 644651006177 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644651006178 Walker A motif; other site 644651006179 ATP binding site [chemical binding]; other site 644651006180 Walker B motif; other site 644651006181 Invasion protein B family; Region: Invas_SpaK; cl04129 644651006182 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 644651006183 type III secretion system protein InvA; Provisional; Region: PRK15337 644651006184 HrpJ-like domain; Region: HrpJ; cl15454 644651006185 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 644651006186 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651006187 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651006188 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 644651006189 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644651006190 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 644651006191 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 644651006192 Type III secretion needle MxiH like; Region: MxiH; cl09641 644651006193 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 644651006194 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 644651006195 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 644651006196 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 644651006197 potential frameshift: common BLAST hit: gi|259910189|ref|YP_002650545.1| transposase/Integrase 644651006198 DDE domain; Region: DDE_Tnp_IS240; pfam13610 644651006199 Integrase core domain; Region: rve; pfam00665 644651006200 Integrase core domain; Region: rve_2; pfam13333 644651006201 Transposase; Region: HTH_Tnp_1; cl17663 644651006202 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 644651006203 sensory histidine kinase DcuS; Provisional; Region: PRK11086 644651006204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651006205 ATP binding site [chemical binding]; other site 644651006206 Mg2+ binding site [ion binding]; other site 644651006207 G-X-G motif; other site 644651006208 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 644651006209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651006210 active site 644651006211 phosphorylation site [posttranslational modification] 644651006212 intermolecular recognition site; other site 644651006213 dimerization interface [polypeptide binding]; other site 644651006214 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 644651006215 ApbE family; Region: ApbE; pfam02424 644651006216 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 644651006217 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 644651006218 putative active site [active] 644651006219 putative FMN binding site [chemical binding]; other site 644651006220 putative substrate binding site [chemical binding]; other site 644651006221 putative catalytic residue [active] 644651006222 FMN-binding domain; Region: FMN_bind; cl01081 644651006223 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 644651006224 L-aspartate oxidase; Provisional; Region: PRK06175 644651006225 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 644651006226 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 644651006227 transmembrane helices; other site 644651006228 fumarate hydratase; Provisional; Region: PRK15389 644651006229 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 644651006230 Fumarase C-terminus; Region: Fumerase_C; pfam05683 644651006231 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 644651006232 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 644651006233 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 644651006234 Trehalase; Region: Trehalase; cl17346 644651006235 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 644651006236 hypothetical protein; Provisional; Region: PRK10457 644651006237 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 644651006238 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644651006239 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644651006240 catalytic residue [active] 644651006241 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 644651006242 dimer interface [polypeptide binding]; other site 644651006243 catalytic triad [active] 644651006244 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 644651006245 DinI-like family; Region: DinI; cl11630 644651006246 Mig-14; Region: Mig-14; pfam07395 644651006247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 644651006248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651006249 Transposase; Region: HTH_Tnp_1; pfam01527 644651006250 putative transposase OrfB; Reviewed; Region: PHA02517 644651006251 HTH-like domain; Region: HTH_21; pfam13276 644651006252 Integrase core domain; Region: rve; pfam00665 644651006253 Integrase core domain; Region: rve_3; pfam13683 644651006254 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 644651006255 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 644651006256 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 644651006257 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 644651006258 Phage protein GP46; Region: GP46; pfam07409 644651006259 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 644651006260 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 644651006261 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 644651006262 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 644651006263 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 644651006264 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 644651006265 Phage tail tube protein; Region: Tail_tube; pfam10618 644651006266 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 644651006267 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 644651006268 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 644651006269 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 644651006270 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 644651006271 oligomerization interface [polypeptide binding]; other site 644651006272 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 644651006273 Phage capsid family; Region: Phage_capsid; pfam05065 644651006274 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 644651006275 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 644651006276 oligomer interface [polypeptide binding]; other site 644651006277 active site residues [active] 644651006278 potential protein location (hypothetical protein) that overlaps protein (prophage LambdaSa04, ClpP endopeptidase (S14) family, non-peptidase homologue, putative) 644651006279 Phage-related protein [Function unknown]; Region: COG4695 644651006280 Phage portal protein; Region: Phage_portal; pfam04860 644651006281 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 644651006282 Phage terminase, small subunit; Region: Terminase_4; pfam05119 644651006283 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 644651006284 active site 644651006285 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 644651006286 virion protein; Provisional; Region: V; PHA02564 644651006287 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 644651006288 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 644651006289 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 644651006290 DNA methylase; Region: N6_N4_Mtase; cl17433 644651006291 DNA methylase; Region: N6_N4_Mtase; pfam01555 644651006292 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 644651006293 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 644651006294 Protein of unknown function (DUF968); Region: DUF968; pfam06147 644651006295 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 644651006296 Helix-turn-helix domain; Region: HTH_36; pfam13730 644651006297 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 644651006298 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 644651006299 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 644651006300 HD domain; Region: HD_3; cl17350 644651006301 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 644651006302 Protein of unknown function (DUF551); Region: DUF551; pfam04448 644651006303 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 644651006304 active site 644651006305 catalytic site [active] 644651006306 substrate binding site [chemical binding]; other site 644651006307 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 644651006308 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 644651006309 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 644651006310 dimer interface [polypeptide binding]; other site 644651006311 active site 644651006312 Int/Topo IB signature motif; other site 644651006313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651006314 Walker A motif; other site 644651006315 ATP binding site [chemical binding]; other site 644651006316 isocitrate dehydrogenase; Validated; Region: PRK07362 644651006317 isocitrate dehydrogenase; Reviewed; Region: PRK07006 644651006318 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 644651006319 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 644651006320 active site 644651006321 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 644651006322 nudix motif; other site 644651006323 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 644651006324 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 644651006325 putative lysogenization regulator; Reviewed; Region: PRK00218 644651006326 adenylosuccinate lyase; Provisional; Region: PRK09285 644651006327 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 644651006328 tetramer interface [polypeptide binding]; other site 644651006329 active site 644651006330 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 644651006331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651006332 active site 644651006333 phosphorylation site [posttranslational modification] 644651006334 intermolecular recognition site; other site 644651006335 dimerization interface [polypeptide binding]; other site 644651006336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651006337 DNA binding site [nucleotide binding] 644651006338 sensor protein PhoQ; Provisional; Region: PRK10815 644651006339 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 644651006340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651006341 dimer interface [polypeptide binding]; other site 644651006342 phosphorylation site [posttranslational modification] 644651006343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651006344 ATP binding site [chemical binding]; other site 644651006345 Mg2+ binding site [ion binding]; other site 644651006346 G-X-G motif; other site 644651006347 Uncharacterized conserved protein [Function unknown]; Region: COG2850 644651006348 Cupin-like domain; Region: Cupin_8; pfam13621 644651006349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651006350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651006351 non-specific DNA binding site [nucleotide binding]; other site 644651006352 salt bridge; other site 644651006353 sequence-specific DNA binding site [nucleotide binding]; other site 644651006354 Cupin domain; Region: Cupin_2; pfam07883 644651006355 benzoate transporter; Region: benE; TIGR00843 644651006356 Benzoate membrane transport protein; Region: BenE; pfam03594 644651006357 NAD-dependent deacetylase; Provisional; Region: PRK00481 644651006358 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 644651006359 NAD+ binding site [chemical binding]; other site 644651006360 substrate binding site [chemical binding]; other site 644651006361 Zn binding site [ion binding]; other site 644651006362 fructokinase; Reviewed; Region: PRK09557 644651006363 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644651006364 nucleotide binding site [chemical binding]; other site 644651006365 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 644651006366 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644651006367 FtsX-like permease family; Region: FtsX; pfam02687 644651006368 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 644651006369 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644651006370 Walker A/P-loop; other site 644651006371 ATP binding site [chemical binding]; other site 644651006372 Q-loop/lid; other site 644651006373 ABC transporter signature motif; other site 644651006374 Walker B; other site 644651006375 D-loop; other site 644651006376 H-loop/switch region; other site 644651006377 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 644651006378 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644651006379 FtsX-like permease family; Region: FtsX; pfam02687 644651006380 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 644651006381 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644651006382 metal binding site [ion binding]; metal-binding site 644651006383 active site 644651006384 I-site; other site 644651006385 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 644651006386 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 644651006387 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 644651006388 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 644651006389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651006390 active site 644651006391 phosphorylation site [posttranslational modification] 644651006392 intermolecular recognition site; other site 644651006393 dimerization interface [polypeptide binding]; other site 644651006394 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 644651006395 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 644651006396 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 644651006397 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 644651006398 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 644651006399 FliG C-terminal domain; Region: FliG_C; pfam01706 644651006400 flagellar assembly protein H; Validated; Region: fliH; PRK05687 644651006401 Flagellar assembly protein FliH; Region: FliH; pfam02108 644651006402 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 644651006403 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 644651006404 Walker A motif/ATP binding site; other site 644651006405 Walker B motif; other site 644651006406 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 644651006407 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 644651006408 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 644651006409 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 644651006410 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 644651006411 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 644651006412 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 644651006413 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 644651006414 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 644651006415 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 644651006416 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 644651006417 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 644651006418 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 644651006419 Phi-29 DNA terminal protein GP3; Region: Phi-29_GP3; cl17520 644651006420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651006421 DNA binding residues [nucleotide binding] 644651006422 dimerization interface [polypeptide binding]; other site 644651006423 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 644651006424 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 644651006425 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 644651006426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651006427 active site 644651006428 motif I; other site 644651006429 motif II; other site 644651006430 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 644651006431 transcription-repair coupling factor; Provisional; Region: PRK10689 644651006432 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 644651006433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651006434 ATP binding site [chemical binding]; other site 644651006435 putative Mg++ binding site [ion binding]; other site 644651006436 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651006437 nucleotide binding region [chemical binding]; other site 644651006438 ATP-binding site [chemical binding]; other site 644651006439 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 644651006440 Homeodomain-like domain; Region: HTH_23; pfam13384 644651006441 Winged helix-turn helix; Region: HTH_29; pfam13551 644651006442 Homeodomain-like domain; Region: HTH_32; pfam13565 644651006443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651006444 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651006445 hypothetical protein; Provisional; Region: PRK11280 644651006446 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 644651006447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644651006448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 644651006449 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 644651006450 beta-hexosaminidase; Provisional; Region: PRK05337 644651006451 thiamine kinase; Region: ycfN_thiK; TIGR02721 644651006452 active site 644651006453 substrate binding site [chemical binding]; other site 644651006454 ATP binding site [chemical binding]; other site 644651006455 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 644651006456 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 644651006457 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 644651006458 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 644651006459 putative dimer interface [polypeptide binding]; other site 644651006460 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 644651006461 nucleotide binding site/active site [active] 644651006462 HIT family signature motif; other site 644651006463 catalytic residue [active] 644651006464 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 644651006465 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644651006466 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644651006467 active site turn [active] 644651006468 phosphorylation site [posttranslational modification] 644651006469 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 644651006470 active site 644651006471 DNA polymerase III subunit delta'; Validated; Region: PRK07993 644651006472 DNA polymerase III subunit delta'; Validated; Region: PRK08485 644651006473 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 644651006474 thymidylate kinase; Validated; Region: tmk; PRK00698 644651006475 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 644651006476 TMP-binding site; other site 644651006477 ATP-binding site [chemical binding]; other site 644651006478 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 644651006479 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 644651006480 dimerization interface [polypeptide binding]; other site 644651006481 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 644651006482 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 644651006483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651006484 catalytic residue [active] 644651006485 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 644651006486 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 644651006487 dimer interface [polypeptide binding]; other site 644651006488 active site 644651006489 acyl carrier protein; Provisional; Region: acpP; PRK00982 644651006490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 644651006491 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 644651006492 NAD(P) binding site [chemical binding]; other site 644651006493 homotetramer interface [polypeptide binding]; other site 644651006494 homodimer interface [polypeptide binding]; other site 644651006495 active site 644651006496 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 644651006497 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 644651006498 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 644651006499 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 644651006500 dimer interface [polypeptide binding]; other site 644651006501 active site 644651006502 CoA binding pocket [chemical binding]; other site 644651006503 putative phosphate acyltransferase; Provisional; Region: PRK05331 644651006504 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 644651006505 hypothetical protein; Provisional; Region: PRK11193 644651006506 Maf-like protein; Region: Maf; pfam02545 644651006507 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 644651006508 active site 644651006509 dimer interface [polypeptide binding]; other site 644651006510 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 644651006511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651006512 RNA binding surface [nucleotide binding]; other site 644651006513 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644651006514 active site 644651006515 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 644651006516 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 644651006517 homodimer interface [polypeptide binding]; other site 644651006518 oligonucleotide binding site [chemical binding]; other site 644651006519 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 644651006520 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 644651006521 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 644651006522 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 644651006523 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 644651006524 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 644651006525 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 644651006526 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 644651006527 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 644651006528 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 644651006529 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 644651006530 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 644651006531 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 644651006532 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 644651006533 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 644651006534 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 644651006535 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 644651006536 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 644651006537 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 644651006538 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 644651006539 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 644651006540 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 644651006541 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 644651006542 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 644651006543 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 644651006544 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 644651006545 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 644651006546 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 644651006547 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 644651006548 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 644651006549 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 644651006550 SAF-like; Region: SAF_2; pfam13144 644651006551 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 644651006552 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 644651006553 FlgN protein; Region: FlgN; cl09176 644651006554 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 644651006555 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 644651006556 Protein of unknown function, DUF480; Region: DUF480; cl01209 644651006557 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 644651006558 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 644651006559 glutaredoxin 2; Provisional; Region: PRK10387 644651006560 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 644651006561 C-terminal domain interface [polypeptide binding]; other site 644651006562 GSH binding site (G-site) [chemical binding]; other site 644651006563 catalytic residues [active] 644651006564 putative dimer interface [polypeptide binding]; other site 644651006565 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 644651006566 N-terminal domain interface [polypeptide binding]; other site 644651006567 lipoprotein; Provisional; Region: PRK10598 644651006568 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 644651006569 active site 644651006570 substrate binding pocket [chemical binding]; other site 644651006571 dimer interface [polypeptide binding]; other site 644651006572 DNA damage-inducible protein I; Provisional; Region: PRK10597 644651006573 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 644651006574 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 644651006575 hydroxyglutarate oxidase; Provisional; Region: PRK11728 644651006576 proline/glycine betaine transporter; Provisional; Region: PRK10642 644651006577 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 644651006578 hypothetical protein; Provisional; Region: PRK03757 644651006579 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 644651006580 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 644651006581 active site residue [active] 644651006582 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 644651006583 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 644651006584 putative acyl-acceptor binding pocket; other site 644651006585 secY/secA suppressor protein; Provisional; Region: PRK11467 644651006586 lipoprotein; Provisional; Region: PRK10175 644651006587 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 644651006588 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 644651006589 Ligand binding site; other site 644651006590 DXD motif; other site 644651006591 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 644651006592 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 644651006593 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 644651006594 Acyltransferase family; Region: Acyl_transf_3; pfam01757 644651006595 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 644651006596 PLD-like domain; Region: PLDc_2; pfam13091 644651006597 putative active site [active] 644651006598 catalytic site [active] 644651006599 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 644651006600 PLD-like domain; Region: PLDc_2; pfam13091 644651006601 putative active site [active] 644651006602 catalytic site [active] 644651006603 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 644651006604 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 644651006605 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 644651006606 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651006607 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644651006608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651006609 putative substrate translocation pore; other site 644651006610 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644651006611 MarR family; Region: MarR; pfam01047 644651006612 Transposase; Region: HTH_Tnp_1; cl17663 644651006613 potential frameshift: common BLAST hit: gi|259910189|ref|YP_002650545.1| transposase/Integrase 644651006614 DDE domain; Region: DDE_Tnp_IS240; pfam13610 644651006615 Integrase core domain; Region: rve; pfam00665 644651006616 Integrase core domain; Region: rve_2; pfam13333 644651006617 Transposase; Region: HTH_Tnp_1; cl17663 644651006618 Transposase; Region: HTH_Tnp_1; cl17663 644651006619 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 644651006620 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 644651006621 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 644651006622 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 644651006623 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 644651006624 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 644651006625 GIY-YIG motif/motif A; other site 644651006626 active site 644651006627 catalytic site [active] 644651006628 putative DNA binding site [nucleotide binding]; other site 644651006629 metal binding site [ion binding]; metal-binding site 644651006630 UvrB/uvrC motif; Region: UVR; pfam02151 644651006631 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 644651006632 response regulator; Provisional; Region: PRK09483 644651006633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651006634 active site 644651006635 phosphorylation site [posttranslational modification] 644651006636 intermolecular recognition site; other site 644651006637 dimerization interface [polypeptide binding]; other site 644651006638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651006639 DNA binding residues [nucleotide binding] 644651006640 dimerization interface [polypeptide binding]; other site 644651006641 hypothetical protein; Provisional; Region: PRK10613 644651006642 Autoinducer synthetase; Region: Autoind_synth; cl17404 644651006643 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 644651006644 Autoinducer binding domain; Region: Autoind_bind; pfam03472 644651006645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651006646 DNA binding residues [nucleotide binding] 644651006647 dimerization interface [polypeptide binding]; other site 644651006648 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 644651006649 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 644651006650 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 644651006651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651006652 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 644651006653 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 644651006654 EamA-like transporter family; Region: EamA; pfam00892 644651006655 hypothetical protein; Provisional; Region: PRK10174 644651006656 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 644651006657 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 644651006658 NAD(P) binding site [chemical binding]; other site 644651006659 catalytic residues [active] 644651006660 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 644651006661 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 644651006662 catalytic core [active] 644651006663 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 644651006664 potential frameshift: common BLAST hit: gi|385786496|ref|YP_005817605.1| transposase 644651006665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651006666 MULE transposase domain; Region: MULE; pfam10551 644651006667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651006668 YccA-like proteins; Region: YccA_like; cd10433 644651006669 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 644651006670 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 644651006671 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 644651006672 Acylphosphatase; Region: Acylphosphatase; cl00551 644651006673 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 644651006674 PUA domain; Region: PUA; cl00607 644651006675 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 644651006676 putative RNA binding site [nucleotide binding]; other site 644651006677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651006678 S-adenosylmethionine binding site [chemical binding]; other site 644651006679 heat shock protein HspQ; Provisional; Region: PRK14129 644651006680 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 644651006681 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 644651006682 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 644651006683 active site 644651006684 dimer interfaces [polypeptide binding]; other site 644651006685 catalytic residues [active] 644651006686 DNA helicase IV; Provisional; Region: helD; PRK11054 644651006687 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 644651006688 Part of AAA domain; Region: AAA_19; pfam13245 644651006689 Family description; Region: UvrD_C_2; pfam13538 644651006690 hypothetical protein; Provisional; Region: PRK11770 644651006691 Domain of unknown function (DUF307); Region: DUF307; pfam03733 644651006692 Domain of unknown function (DUF307); Region: DUF307; pfam03733 644651006693 TIGR01666 family membrane protein; Region: YCCS 644651006694 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 644651006695 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 644651006696 TfoX N-terminal domain; Region: TfoX_N; pfam04993 644651006697 TfoX C-terminal domain; Region: TfoX_C; pfam04994 644651006698 SOS cell division inhibitor; Provisional; Region: PRK10595 644651006699 outer membrane protein A; Reviewed; Region: PRK10808 644651006700 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 644651006701 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 644651006702 ligand binding site [chemical binding]; other site 644651006703 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 644651006704 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 644651006705 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 644651006706 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 644651006707 active site 1 [active] 644651006708 dimer interface [polypeptide binding]; other site 644651006709 active site 2 [active] 644651006710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 644651006711 Protein of unknown function (DUF330); Region: DUF330; pfam03886 644651006712 paraquat-inducible protein B; Provisional; Region: PRK10807 644651006713 mce related protein; Region: MCE; pfam02470 644651006714 mce related protein; Region: MCE; pfam02470 644651006715 mce related protein; Region: MCE; pfam02470 644651006716 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 644651006717 Paraquat-inducible protein A; Region: PqiA; pfam04403 644651006718 Paraquat-inducible protein A; Region: PqiA; pfam04403 644651006719 ABC transporter ATPase component; Reviewed; Region: PRK11147 644651006720 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651006721 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651006722 ABC transporter; Region: ABC_tran_2; pfam12848 644651006723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651006724 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 644651006725 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 644651006726 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 644651006727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651006728 S-adenosylmethionine binding site [chemical binding]; other site 644651006729 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 644651006730 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 644651006731 MOSC domain; Region: MOSC; pfam03473 644651006732 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644651006733 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 644651006734 catalytic loop [active] 644651006735 iron binding site [ion binding]; other site 644651006736 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 644651006737 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 644651006738 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 644651006739 quinone interaction residues [chemical binding]; other site 644651006740 active site 644651006741 catalytic residues [active] 644651006742 FMN binding site [chemical binding]; other site 644651006743 substrate binding site [chemical binding]; other site 644651006744 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 644651006745 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644651006746 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 644651006747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651006748 substrate binding pocket [chemical binding]; other site 644651006749 membrane-bound complex binding site; other site 644651006750 hinge residues; other site 644651006751 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 644651006752 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 644651006753 dimer interface [polypeptide binding]; other site 644651006754 active site 644651006755 non-prolyl cis peptide bond; other site 644651006756 insertion regions; other site 644651006757 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 644651006758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651006759 dimer interface [polypeptide binding]; other site 644651006760 conserved gate region; other site 644651006761 putative PBP binding loops; other site 644651006762 ABC-ATPase subunit interface; other site 644651006763 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 644651006764 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 644651006765 Walker A/P-loop; other site 644651006766 ATP binding site [chemical binding]; other site 644651006767 Q-loop/lid; other site 644651006768 ABC transporter signature motif; other site 644651006769 Walker B; other site 644651006770 D-loop; other site 644651006771 H-loop/switch region; other site 644651006772 aminopeptidase N; Provisional; Region: pepN; PRK14015 644651006773 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 644651006774 active site 644651006775 Zn binding site [ion binding]; other site 644651006776 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 644651006777 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 644651006778 active site 644651006779 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 644651006780 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 644651006781 putative dimer interface [polypeptide binding]; other site 644651006782 putative anticodon binding site; other site 644651006783 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 644651006784 homodimer interface [polypeptide binding]; other site 644651006785 motif 1; other site 644651006786 motif 2; other site 644651006787 active site 644651006788 motif 3; other site 644651006789 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 644651006790 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 644651006791 trimer interface [polypeptide binding]; other site 644651006792 eyelet of channel; other site 644651006793 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 644651006794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651006795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651006796 homodimer interface [polypeptide binding]; other site 644651006797 catalytic residue [active] 644651006798 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 644651006799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 644651006800 Peptidase M15; Region: Peptidase_M15_3; cl01194 644651006801 murein L,D-transpeptidase; Provisional; Region: PRK10594 644651006802 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 644651006803 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644651006804 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644651006805 cell division protein MukB; Provisional; Region: mukB; PRK04863 644651006806 MukB N-terminal; Region: MukB; pfam04310 644651006807 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 644651006808 condesin subunit E; Provisional; Region: PRK05256 644651006809 condesin subunit F; Provisional; Region: PRK05260 644651006810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 644651006811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651006812 S-adenosylmethionine binding site [chemical binding]; other site 644651006813 Uncharacterized conserved protein [Function unknown]; Region: COG1434 644651006814 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 644651006815 putative active site [active] 644651006816 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 644651006817 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 644651006818 Ligand binding site; other site 644651006819 oligomer interface; other site 644651006820 Trm112p-like protein; Region: Trm112p; cl01066 644651006821 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 644651006822 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 644651006823 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 644651006824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644651006825 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 644651006826 Walker A/P-loop; other site 644651006827 ATP binding site [chemical binding]; other site 644651006828 Q-loop/lid; other site 644651006829 ABC transporter signature motif; other site 644651006830 Walker B; other site 644651006831 D-loop; other site 644651006832 H-loop/switch region; other site 644651006833 ComEC family competence protein; Provisional; Region: PRK11539 644651006834 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 644651006835 Competence protein; Region: Competence; pfam03772 644651006836 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 644651006837 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 644651006838 IHF dimer interface [polypeptide binding]; other site 644651006839 IHF - DNA interface [nucleotide binding]; other site 644651006840 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 644651006841 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 644651006842 RNA binding site [nucleotide binding]; other site 644651006843 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 644651006844 RNA binding site [nucleotide binding]; other site 644651006845 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 644651006846 RNA binding site [nucleotide binding]; other site 644651006847 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644651006848 RNA binding site [nucleotide binding]; other site 644651006849 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 644651006850 RNA binding site [nucleotide binding]; other site 644651006851 cytidylate kinase; Provisional; Region: cmk; PRK00023 644651006852 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 644651006853 CMP-binding site; other site 644651006854 The sites determining sugar specificity; other site 644651006855 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 644651006856 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 644651006857 hinge; other site 644651006858 active site 644651006859 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 644651006860 homodimer interface [polypeptide binding]; other site 644651006861 substrate-cofactor binding pocket; other site 644651006862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651006863 catalytic residue [active] 644651006864 uncharacterized domain; Region: TIGR00702 644651006865 YcaO-like family; Region: YcaO; pfam02624 644651006866 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 644651006867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651006868 putative MFS family transporter protein; Provisional; Region: PRK03633 644651006869 putative substrate translocation pore; other site 644651006870 seryl-tRNA synthetase; Provisional; Region: PRK05431 644651006871 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 644651006872 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 644651006873 dimer interface [polypeptide binding]; other site 644651006874 active site 644651006875 motif 1; other site 644651006876 motif 2; other site 644651006877 motif 3; other site 644651006878 recombination factor protein RarA; Reviewed; Region: PRK13342 644651006879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651006880 Walker A motif; other site 644651006881 ATP binding site [chemical binding]; other site 644651006882 Walker B motif; other site 644651006883 arginine finger; other site 644651006884 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 644651006885 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 644651006886 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 644651006887 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 644651006888 DNA translocase FtsK; Provisional; Region: PRK10263 644651006889 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 644651006890 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 644651006891 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 644651006892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644651006893 putative DNA binding site [nucleotide binding]; other site 644651006894 putative Zn2+ binding site [ion binding]; other site 644651006895 AsnC family; Region: AsnC_trans_reg; pfam01037 644651006896 thioredoxin reductase; Provisional; Region: PRK10262 644651006897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644651006898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644651006899 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 644651006900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644651006901 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 644651006902 Walker A/P-loop; other site 644651006903 ATP binding site [chemical binding]; other site 644651006904 Q-loop/lid; other site 644651006905 ABC transporter signature motif; other site 644651006906 Walker B; other site 644651006907 D-loop; other site 644651006908 H-loop/switch region; other site 644651006909 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 644651006910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651006911 Walker A/P-loop; other site 644651006912 ATP binding site [chemical binding]; other site 644651006913 Q-loop/lid; other site 644651006914 ABC transporter signature motif; other site 644651006915 Walker B; other site 644651006916 D-loop; other site 644651006917 H-loop/switch region; other site 644651006918 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 644651006919 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 644651006920 rRNA binding site [nucleotide binding]; other site 644651006921 predicted 30S ribosome binding site; other site 644651006922 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 644651006923 Clp amino terminal domain; Region: Clp_N; pfam02861 644651006924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651006925 Walker A motif; other site 644651006926 ATP binding site [chemical binding]; other site 644651006927 Walker B motif; other site 644651006928 arginine finger; other site 644651006929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651006930 Walker A motif; other site 644651006931 ATP binding site [chemical binding]; other site 644651006932 Walker B motif; other site 644651006933 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 644651006934 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 644651006935 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644651006936 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 644651006937 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 644651006938 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 644651006939 putative active site [active] 644651006940 putative metal-binding site [ion binding]; other site 644651006941 pyruvate dehydrogenase; Provisional; Region: PRK09124 644651006942 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 644651006943 PYR/PP interface [polypeptide binding]; other site 644651006944 dimer interface [polypeptide binding]; other site 644651006945 tetramer interface [polypeptide binding]; other site 644651006946 TPP binding site [chemical binding]; other site 644651006947 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644651006948 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 644651006949 TPP-binding site [chemical binding]; other site 644651006950 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 644651006951 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 644651006952 tetramer interface [polypeptide binding]; other site 644651006953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651006954 catalytic residue [active] 644651006955 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 644651006956 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 644651006957 amidase catalytic site [active] 644651006958 Zn binding residues [ion binding]; other site 644651006959 substrate binding site [chemical binding]; other site 644651006960 hypothetical protein; Provisional; Region: PRK02877 644651006961 putative lipoprotein; Provisional; Region: PRK10533 644651006962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651006963 Walker A/P-loop; other site 644651006964 ATP binding site [chemical binding]; other site 644651006965 ABC transporter; Region: ABC_tran; pfam00005 644651006966 Q-loop/lid; other site 644651006967 ABC transporter signature motif; other site 644651006968 Walker B; other site 644651006969 D-loop; other site 644651006970 H-loop/switch region; other site 644651006971 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 644651006972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651006973 substrate binding pocket [chemical binding]; other site 644651006974 membrane-bound complex binding site; other site 644651006975 hinge residues; other site 644651006976 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651006977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651006978 dimer interface [polypeptide binding]; other site 644651006979 conserved gate region; other site 644651006980 putative PBP binding loops; other site 644651006981 ABC-ATPase subunit interface; other site 644651006982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651006983 dimer interface [polypeptide binding]; other site 644651006984 conserved gate region; other site 644651006985 putative PBP binding loops; other site 644651006986 ABC-ATPase subunit interface; other site 644651006987 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 644651006988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651006989 substrate binding pocket [chemical binding]; other site 644651006990 membrane-bound complex binding site; other site 644651006991 hinge residues; other site 644651006992 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 644651006993 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644651006994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651006995 dimer interface [polypeptide binding]; other site 644651006996 conserved gate region; other site 644651006997 putative PBP binding loops; other site 644651006998 ABC-ATPase subunit interface; other site 644651006999 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 644651007000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007001 dimer interface [polypeptide binding]; other site 644651007002 conserved gate region; other site 644651007003 putative PBP binding loops; other site 644651007004 ABC-ATPase subunit interface; other site 644651007005 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 644651007006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651007007 Walker A/P-loop; other site 644651007008 ATP binding site [chemical binding]; other site 644651007009 Q-loop/lid; other site 644651007010 ABC transporter signature motif; other site 644651007011 Walker B; other site 644651007012 D-loop; other site 644651007013 H-loop/switch region; other site 644651007014 TOBE domain; Region: TOBE_2; pfam08402 644651007015 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 644651007016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644651007017 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 644651007018 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 644651007019 dimer interface [polypeptide binding]; other site 644651007020 FMN binding site [chemical binding]; other site 644651007021 NADPH bind site [chemical binding]; other site 644651007022 hypothetical protein; Provisional; Region: PRK10591 644651007023 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 644651007024 GSH binding site [chemical binding]; other site 644651007025 catalytic residues [active] 644651007026 putative transporter; Provisional; Region: PRK04972 644651007027 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 644651007028 TrkA-C domain; Region: TrkA_C; pfam02080 644651007029 TrkA-C domain; Region: TrkA_C; pfam02080 644651007030 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 644651007031 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 644651007032 active site 644651007033 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 644651007034 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 644651007035 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 644651007036 serine transporter; Region: stp; TIGR00814 644651007037 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 644651007038 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 644651007039 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 644651007040 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 644651007041 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644651007042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007043 dimer interface [polypeptide binding]; other site 644651007044 conserved gate region; other site 644651007045 putative PBP binding loops; other site 644651007046 ABC-ATPase subunit interface; other site 644651007047 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 644651007048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007049 dimer interface [polypeptide binding]; other site 644651007050 conserved gate region; other site 644651007051 putative PBP binding loops; other site 644651007052 ABC-ATPase subunit interface; other site 644651007053 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 644651007054 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 644651007055 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 644651007056 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651007057 Walker A/P-loop; other site 644651007058 ATP binding site [chemical binding]; other site 644651007059 Q-loop/lid; other site 644651007060 ABC transporter signature motif; other site 644651007061 Walker B; other site 644651007062 D-loop; other site 644651007063 H-loop/switch region; other site 644651007064 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644651007065 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651007066 Walker A/P-loop; other site 644651007067 ATP binding site [chemical binding]; other site 644651007068 Q-loop/lid; other site 644651007069 ABC transporter signature motif; other site 644651007070 Walker B; other site 644651007071 D-loop; other site 644651007072 H-loop/switch region; other site 644651007073 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 644651007074 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 644651007075 catalytic nucleophile [active] 644651007076 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 644651007077 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 644651007078 dimer interface [polypeptide binding]; other site 644651007079 putative functional site; other site 644651007080 putative MPT binding site; other site 644651007081 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 644651007082 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 644651007083 ATP binding site [chemical binding]; other site 644651007084 substrate interface [chemical binding]; other site 644651007085 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 644651007086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651007087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651007088 Walker A/P-loop; other site 644651007089 ATP binding site [chemical binding]; other site 644651007090 ABC transporter signature motif; other site 644651007091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651007092 Walker B; other site 644651007093 ABC transporter; Region: ABC_tran_2; pfam12848 644651007094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651007095 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 644651007096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651007097 putative substrate translocation pore; other site 644651007098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651007099 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 644651007100 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644651007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651007102 putative substrate translocation pore; other site 644651007103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651007104 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 644651007105 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 644651007106 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651007107 manganese transport regulator MntR; Provisional; Region: PRK11050 644651007108 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 644651007109 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 644651007110 outer membrane protein X; Provisional; Region: ompX; PRK09408 644651007111 threonine and homoserine efflux system; Provisional; Region: PRK10532 644651007112 EamA-like transporter family; Region: EamA; pfam00892 644651007113 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 644651007114 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 644651007115 dimerization interface [polypeptide binding]; other site 644651007116 DPS ferroxidase diiron center [ion binding]; other site 644651007117 ion pore; other site 644651007118 hypothetical protein; Provisional; Region: PRK11019 644651007119 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 644651007120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651007121 substrate binding pocket [chemical binding]; other site 644651007122 membrane-bound complex binding site; other site 644651007123 hinge residues; other site 644651007124 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651007125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007126 dimer interface [polypeptide binding]; other site 644651007127 conserved gate region; other site 644651007128 putative PBP binding loops; other site 644651007129 ABC-ATPase subunit interface; other site 644651007130 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 644651007131 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644651007132 Walker A/P-loop; other site 644651007133 ATP binding site [chemical binding]; other site 644651007134 Q-loop/lid; other site 644651007135 ABC transporter signature motif; other site 644651007136 Walker B; other site 644651007137 D-loop; other site 644651007138 H-loop/switch region; other site 644651007139 Homeodomain-like domain; Region: HTH_23; pfam13384 644651007140 Winged helix-turn helix; Region: HTH_29; pfam13551 644651007141 Homeodomain-like domain; Region: HTH_32; pfam13565 644651007142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651007143 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651007144 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644651007145 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 644651007146 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 644651007147 Flavin Reductases; Region: FlaRed; cl00801 644651007148 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 644651007149 N-formylglutamate amidohydrolase; Region: FGase; cl01522 644651007150 N-formylglutamate amidohydrolase; Region: FGase; cl01522 644651007151 imidazolonepropionase; Validated; Region: PRK09356 644651007152 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 644651007153 active site 644651007154 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 644651007155 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 644651007156 active site 644651007157 HutD; Region: HutD; cl01532 644651007158 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 644651007159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651007160 DNA-binding site [nucleotide binding]; DNA binding site 644651007161 UTRA domain; Region: UTRA; pfam07702 644651007162 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 644651007163 active sites [active] 644651007164 tetramer interface [polypeptide binding]; other site 644651007165 urocanate hydratase; Provisional; Region: PRK05414 644651007166 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 644651007167 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 644651007168 metal binding site [ion binding]; metal-binding site 644651007169 putative dimer interface [polypeptide binding]; other site 644651007170 glycosyl transferase family protein; Provisional; Region: PRK08136 644651007171 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 644651007172 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 644651007173 DEAD_2; Region: DEAD_2; pfam06733 644651007174 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 644651007175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651007176 Coenzyme A binding pocket [chemical binding]; other site 644651007177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651007178 sequence-specific DNA binding site [nucleotide binding]; other site 644651007179 salt bridge; other site 644651007180 transcriptional regulator MirA; Provisional; Region: PRK15043 644651007181 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 644651007182 DNA binding residues [nucleotide binding] 644651007183 SnoaL-like domain; Region: SnoaL_2; pfam12680 644651007184 short chain dehydrogenase; Provisional; Region: PRK06101 644651007185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651007186 NAD(P) binding site [chemical binding]; other site 644651007187 active site 644651007188 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 644651007189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 644651007190 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 644651007191 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 644651007192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651007193 S-adenosylmethionine binding site [chemical binding]; other site 644651007194 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 644651007195 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651007196 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 644651007197 nudix motif; other site 644651007198 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 644651007199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644651007200 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 644651007201 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 644651007202 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 644651007203 D-lactate dehydrogenase; Provisional; Region: PRK11183 644651007204 FAD binding domain; Region: FAD_binding_4; pfam01565 644651007205 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 644651007206 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 644651007207 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 644651007208 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644651007209 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 644651007210 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 644651007211 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 644651007212 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644651007213 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 644651007214 potential frameshift: common BLAST hit: gi|292898947|ref|YP_003538316.1| glycosyl hydrolase 644651007215 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 644651007216 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 644651007217 L,D-transpeptidase; Provisional; Region: PRK10260 644651007218 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 644651007219 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644651007220 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 644651007221 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 644651007222 FMN binding site [chemical binding]; other site 644651007223 active site 644651007224 catalytic residues [active] 644651007225 substrate binding site [chemical binding]; other site 644651007226 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 644651007227 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644651007228 ATP binding site [chemical binding]; other site 644651007229 Mg++ binding site [ion binding]; other site 644651007230 motif III; other site 644651007231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651007232 nucleotide binding region [chemical binding]; other site 644651007233 ATP-binding site [chemical binding]; other site 644651007234 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 644651007235 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 644651007236 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 644651007237 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 644651007238 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 644651007239 MoaE homodimer interface [polypeptide binding]; other site 644651007240 MoaD interaction [polypeptide binding]; other site 644651007241 active site residues [active] 644651007242 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 644651007243 MoaE interaction surface [polypeptide binding]; other site 644651007244 MoeB interaction surface [polypeptide binding]; other site 644651007245 thiocarboxylated glycine; other site 644651007246 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 644651007247 trimer interface [polypeptide binding]; other site 644651007248 dimer interface [polypeptide binding]; other site 644651007249 putative active site [active] 644651007250 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 644651007251 MPT binding site; other site 644651007252 trimer interface [polypeptide binding]; other site 644651007253 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 644651007254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651007255 FeS/SAM binding site; other site 644651007256 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 644651007257 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 644651007258 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 644651007259 phosphate binding site [ion binding]; other site 644651007260 putative substrate binding pocket [chemical binding]; other site 644651007261 dimer interface [polypeptide binding]; other site 644651007262 excinuclease ABC subunit B; Provisional; Region: PRK05298 644651007263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651007264 ATP binding site [chemical binding]; other site 644651007265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644651007266 nucleotide binding region [chemical binding]; other site 644651007267 ATP-binding site [chemical binding]; other site 644651007268 Ultra-violet resistance protein B; Region: UvrB; pfam12344 644651007269 UvrB/uvrC motif; Region: UVR; pfam02151 644651007270 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 644651007271 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 644651007272 Walker A/P-loop; other site 644651007273 ATP binding site [chemical binding]; other site 644651007274 Q-loop/lid; other site 644651007275 ABC transporter signature motif; other site 644651007276 Walker B; other site 644651007277 D-loop; other site 644651007278 H-loop/switch region; other site 644651007279 AAA domain; Region: AAA_26; pfam13500 644651007280 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 644651007281 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 644651007282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651007283 S-adenosylmethionine binding site [chemical binding]; other site 644651007284 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 644651007285 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 644651007286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651007287 catalytic residue [active] 644651007288 biotin synthase; Provisional; Region: PRK15108 644651007289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651007290 FeS/SAM binding site; other site 644651007291 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 644651007292 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 644651007293 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644651007294 inhibitor-cofactor binding pocket; inhibition site 644651007295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651007296 catalytic residue [active] 644651007297 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 644651007298 Prostaglandin dehydrogenases; Region: PGDH; cd05288 644651007299 NAD(P) binding site [chemical binding]; other site 644651007300 substrate binding site [chemical binding]; other site 644651007301 dimer interface [polypeptide binding]; other site 644651007302 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 644651007303 substrate binding site [chemical binding]; other site 644651007304 6-phosphogluconolactonase; Provisional; Region: PRK11028 644651007305 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 644651007306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651007307 active site 644651007308 motif I; other site 644651007309 motif II; other site 644651007310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651007311 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 644651007312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651007313 Walker A/P-loop; other site 644651007314 ATP binding site [chemical binding]; other site 644651007315 Q-loop/lid; other site 644651007316 ABC transporter signature motif; other site 644651007317 Walker B; other site 644651007318 D-loop; other site 644651007319 H-loop/switch region; other site 644651007320 TOBE domain; Region: TOBE; pfam03459 644651007321 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 644651007322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007323 dimer interface [polypeptide binding]; other site 644651007324 conserved gate region; other site 644651007325 putative PBP binding loops; other site 644651007326 ABC-ATPase subunit interface; other site 644651007327 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 644651007328 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644651007329 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 644651007330 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 644651007331 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 644651007332 molybdenum-pterin binding domain; Region: Mop; TIGR00638 644651007333 TOBE domain; Region: TOBE; cl01440 644651007334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 644651007335 Walker A/P-loop; other site 644651007336 ATP binding site [chemical binding]; other site 644651007337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651007338 MULE transposase domain; Region: MULE; pfam10551 644651007339 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 644651007340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651007341 Walker A/P-loop; other site 644651007342 ATP binding site [chemical binding]; other site 644651007343 Q-loop/lid; other site 644651007344 ABC transporter signature motif; other site 644651007345 Walker B; other site 644651007346 D-loop; other site 644651007347 H-loop/switch region; other site 644651007348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651007349 Walker A/P-loop; other site 644651007350 ATP binding site [chemical binding]; other site 644651007351 Q-loop/lid; other site 644651007352 ABC transporter signature motif; other site 644651007353 Walker B; other site 644651007354 D-loop; other site 644651007355 H-loop/switch region; other site 644651007356 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 644651007357 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 644651007358 dimer interface [polypeptide binding]; other site 644651007359 active site 644651007360 galactokinase; Provisional; Region: PRK05101 644651007361 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 644651007362 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644651007363 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 644651007364 active site 644651007365 catalytic residues [active] 644651007366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644651007367 catalytic core [active] 644651007368 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644651007369 RHS Repeat; Region: RHS_repeat; pfam05593 644651007370 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651007371 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651007372 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 644651007373 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 644651007374 YbgS-like protein; Region: YbgS; pfam13985 644651007375 zinc transporter ZitB; Provisional; Region: PRK03557 644651007376 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 644651007377 quinolinate synthetase; Provisional; Region: PRK09375 644651007378 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 644651007379 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 644651007380 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 644651007381 DNA binding site [nucleotide binding] 644651007382 active site 644651007383 potential frameshift: common BLAST hit: gi|292487664|ref|YP_003530537.1| DNA methylation and regulatory protein 644651007384 Helix-turn-helix domain; Region: HTH_18; pfam12833 644651007385 potential protein location (hypothetical protein) that overlaps protein (DNA methylation and regulatory protein) 644651007386 tol-pal system protein YbgF; Provisional; Region: PRK10803 644651007387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644651007388 TPR motif; other site 644651007389 binding surface 644651007390 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 644651007391 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 644651007392 ligand binding site [chemical binding]; other site 644651007393 translocation protein TolB; Provisional; Region: tolB; PRK03629 644651007394 TolB amino-terminal domain; Region: TolB_N; pfam04052 644651007395 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 644651007396 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 644651007397 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 644651007398 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 644651007399 TolA C-terminal; Region: TolA; pfam06519 644651007400 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 644651007401 colicin uptake protein TolR; Provisional; Region: PRK11024 644651007402 colicin uptake protein TolQ; Provisional; Region: PRK10801 644651007403 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644651007404 active site 644651007405 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 644651007406 CoA binding domain; Region: CoA_binding; pfam02629 644651007407 CoA-ligase; Region: Ligase_CoA; pfam00549 644651007408 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 644651007409 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 644651007410 CoA-ligase; Region: Ligase_CoA; pfam00549 644651007411 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 644651007412 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644651007413 E3 interaction surface; other site 644651007414 lipoyl attachment site [posttranslational modification]; other site 644651007415 e3 binding domain; Region: E3_binding; pfam02817 644651007416 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 644651007417 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 644651007418 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 644651007419 TPP-binding site [chemical binding]; other site 644651007420 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 644651007421 dimer interface [polypeptide binding]; other site 644651007422 PYR/PP interface [polypeptide binding]; other site 644651007423 TPP binding site [chemical binding]; other site 644651007424 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 644651007425 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 644651007426 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 644651007427 L-aspartate oxidase; Provisional; Region: PRK06175 644651007428 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 644651007429 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 644651007430 SdhC subunit interface [polypeptide binding]; other site 644651007431 proximal heme binding site [chemical binding]; other site 644651007432 cardiolipin binding site; other site 644651007433 Iron-sulfur protein interface; other site 644651007434 proximal quinone binding site [chemical binding]; other site 644651007435 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 644651007436 Iron-sulfur protein interface; other site 644651007437 proximal quinone binding site [chemical binding]; other site 644651007438 SdhD (CybS) interface [polypeptide binding]; other site 644651007439 proximal heme binding site [chemical binding]; other site 644651007440 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 644651007441 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 644651007442 dimer interface [polypeptide binding]; other site 644651007443 active site 644651007444 citrylCoA binding site [chemical binding]; other site 644651007445 NADH binding [chemical binding]; other site 644651007446 cationic pore residues; other site 644651007447 oxalacetate/citrate binding site [chemical binding]; other site 644651007448 coenzyme A binding site [chemical binding]; other site 644651007449 catalytic triad [active] 644651007450 endonuclease VIII; Provisional; Region: PRK10445 644651007451 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 644651007452 DNA binding site [nucleotide binding] 644651007453 catalytic residue [active] 644651007454 H2TH interface [polypeptide binding]; other site 644651007455 putative catalytic residues [active] 644651007456 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 644651007457 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644651007458 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 644651007459 putative substrate binding pocket [chemical binding]; other site 644651007460 AC domain interface; other site 644651007461 catalytic triad [active] 644651007462 AB domain interface; other site 644651007463 interchain disulfide; other site 644651007464 Predicted membrane protein [Function unknown]; Region: COG3817 644651007465 Protein of unknown function (DUF979); Region: DUF979; pfam06166 644651007466 Protein of unknown function (DUF969); Region: DUF969; pfam06149 644651007467 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 644651007468 putative active site [active] 644651007469 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 644651007470 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 644651007471 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 644651007472 Uncharacterized conserved protein [Function unknown]; Region: COG0327 644651007473 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 644651007474 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 644651007475 DNA photolyase; Region: DNA_photolyase; pfam00875 644651007476 Protein of unknown function (DUF523); Region: DUF523; pfam04463 644651007477 Uncharacterized conserved protein [Function unknown]; Region: COG3272 644651007478 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 644651007479 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 644651007480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651007481 active site 644651007482 phosphorylation site [posttranslational modification] 644651007483 intermolecular recognition site; other site 644651007484 dimerization interface [polypeptide binding]; other site 644651007485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651007486 DNA binding site [nucleotide binding] 644651007487 phosphoglucomutase; Validated; Region: PRK07564 644651007488 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 644651007489 active site 644651007490 substrate binding site [chemical binding]; other site 644651007491 metal binding site [ion binding]; metal-binding site 644651007492 replication initiation regulator SeqA; Provisional; Region: PRK11187 644651007493 acyl-CoA esterase; Provisional; Region: PRK10673 644651007494 PGAP1-like protein; Region: PGAP1; pfam07819 644651007495 LexA regulated protein; Provisional; Region: PRK11675 644651007496 flavodoxin FldA; Validated; Region: PRK09267 644651007497 ferric uptake regulator; Provisional; Region: fur; PRK09462 644651007498 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644651007499 metal binding site 2 [ion binding]; metal-binding site 644651007500 putative DNA binding helix; other site 644651007501 metal binding site 1 [ion binding]; metal-binding site 644651007502 dimer interface [polypeptide binding]; other site 644651007503 structural Zn2+ binding site [ion binding]; other site 644651007504 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 644651007505 aromatic amino acid transport protein; Region: araaP; TIGR00837 644651007506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 644651007507 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 644651007508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644651007509 active site 644651007510 HIGH motif; other site 644651007511 nucleotide binding site [chemical binding]; other site 644651007512 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 644651007513 KMSKS motif; other site 644651007514 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 644651007515 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 644651007516 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644651007517 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644651007518 active site turn [active] 644651007519 phosphorylation site [posttranslational modification] 644651007520 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 644651007521 HPr interaction site; other site 644651007522 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644651007523 active site 644651007524 phosphorylation site [posttranslational modification] 644651007525 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 644651007526 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 644651007527 active site 644651007528 trimer interface [polypeptide binding]; other site 644651007529 allosteric site; other site 644651007530 active site lid [active] 644651007531 hexamer (dimer of trimers) interface [polypeptide binding]; other site 644651007532 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 644651007533 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 644651007534 active site 644651007535 dimer interface [polypeptide binding]; other site 644651007536 MarR family; Region: MarR; pfam01047 644651007537 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644651007538 ROK family; Region: ROK; pfam00480 644651007539 UMP phosphatase; Provisional; Region: PRK10444 644651007540 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 644651007541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651007542 asparagine synthetase B; Provisional; Region: asnB; PRK09431 644651007543 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 644651007544 active site 644651007545 dimer interface [polypeptide binding]; other site 644651007546 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 644651007547 Ligand Binding Site [chemical binding]; other site 644651007548 Molecular Tunnel; other site 644651007549 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 644651007550 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 644651007551 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 644651007552 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 644651007553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651007554 FeS/SAM binding site; other site 644651007555 TRAM domain; Region: TRAM; pfam01938 644651007556 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 644651007557 PhoH-like protein; Region: PhoH; pfam02562 644651007558 metal-binding heat shock protein; Provisional; Region: PRK00016 644651007559 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 644651007560 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644651007561 Transporter associated domain; Region: CorC_HlyC; smart01091 644651007562 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 644651007563 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 644651007564 putative active site [active] 644651007565 catalytic triad [active] 644651007566 putative dimer interface [polypeptide binding]; other site 644651007567 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 644651007568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651007569 substrate binding pocket [chemical binding]; other site 644651007570 membrane-bound complex binding site; other site 644651007571 hinge residues; other site 644651007572 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651007573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007574 dimer interface [polypeptide binding]; other site 644651007575 conserved gate region; other site 644651007576 putative PBP binding loops; other site 644651007577 ABC-ATPase subunit interface; other site 644651007578 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651007579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007580 dimer interface [polypeptide binding]; other site 644651007581 conserved gate region; other site 644651007582 putative PBP binding loops; other site 644651007583 ABC-ATPase subunit interface; other site 644651007584 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644651007585 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644651007586 Walker A/P-loop; other site 644651007587 ATP binding site [chemical binding]; other site 644651007588 Q-loop/lid; other site 644651007589 ABC transporter signature motif; other site 644651007590 Walker B; other site 644651007591 D-loop; other site 644651007592 H-loop/switch region; other site 644651007593 hypothetical protein; Provisional; Region: PRK11032 644651007594 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 644651007595 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 644651007596 HIGH motif; other site 644651007597 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644651007598 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644651007599 active site 644651007600 KMSKS motif; other site 644651007601 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 644651007602 tRNA binding surface [nucleotide binding]; other site 644651007603 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 644651007604 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 644651007605 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 644651007606 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 644651007607 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 644651007608 active site 644651007609 (T/H)XGH motif; other site 644651007610 ribosome-associated protein; Provisional; Region: PRK11538 644651007611 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 644651007612 penicillin-binding protein 2; Provisional; Region: PRK10795 644651007613 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644651007614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644651007615 cell wall shape-determining protein; Provisional; Region: PRK10794 644651007616 rare lipoprotein A; Provisional; Region: PRK10672 644651007617 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 644651007618 Sporulation related domain; Region: SPOR; pfam05036 644651007619 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 644651007620 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 644651007621 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 644651007622 hypothetical protein; Provisional; Region: PRK04998 644651007623 lipoate-protein ligase B; Provisional; Region: PRK14342 644651007624 lipoyl synthase; Provisional; Region: PRK05481 644651007625 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651007626 FeS/SAM binding site; other site 644651007627 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 644651007628 Predicted amidohydrolase [General function prediction only]; Region: COG0388 644651007629 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 644651007630 putative active site [active] 644651007631 catalytic triad [active] 644651007632 putative dimer interface [polypeptide binding]; other site 644651007633 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644651007634 DNA-binding site [nucleotide binding]; DNA binding site 644651007635 RNA-binding motif; other site 644651007636 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 644651007637 putative transporter; Provisional; Region: PRK09821 644651007638 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 644651007639 putative aldolase; Validated; Region: PRK08130 644651007640 intersubunit interface [polypeptide binding]; other site 644651007641 active site 644651007642 Zn2+ binding site [ion binding]; other site 644651007643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 644651007644 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 644651007645 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 644651007646 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644651007647 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 644651007648 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644651007649 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 644651007650 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644651007651 putative NAD(P) binding site [chemical binding]; other site 644651007652 potential protein location (hypothetical protein) that overlaps protein (alcohol dehydrogenase) 644651007653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651007654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651007655 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 644651007656 putative effector binding pocket; other site 644651007657 putative dimerization interface [polypeptide binding]; other site 644651007658 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 644651007659 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 644651007660 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 644651007661 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 644651007662 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 644651007663 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 644651007664 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 644651007665 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 644651007666 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 644651007667 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 644651007668 putative active site [active] 644651007669 putative catalytic site [active] 644651007670 putative Zn binding site [ion binding]; other site 644651007671 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 644651007672 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 644651007673 active site 644651007674 substrate binding site [chemical binding]; other site 644651007675 cosubstrate binding site; other site 644651007676 catalytic site [active] 644651007677 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 644651007678 active site 644651007679 hexamer interface [polypeptide binding]; other site 644651007680 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 644651007681 NAD binding site [chemical binding]; other site 644651007682 substrate binding site [chemical binding]; other site 644651007683 active site 644651007684 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 644651007685 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 644651007686 Ligand binding site; other site 644651007687 Putative Catalytic site; other site 644651007688 DXD motif; other site 644651007689 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 644651007690 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 644651007691 inhibitor-cofactor binding pocket; inhibition site 644651007692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651007693 catalytic residue [active] 644651007694 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 644651007695 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 644651007696 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 644651007697 Trp docking motif [polypeptide binding]; other site 644651007698 putative active site [active] 644651007699 potential frameshift: common BLAST hit: gi|385787665|ref|YP_005818774.1| Putative outer membrane receptor 644651007700 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 644651007701 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 644651007702 ligand-binding site [chemical binding]; other site 644651007703 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 644651007704 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 644651007705 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 644651007706 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 644651007707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651007708 Walker A/P-loop; other site 644651007709 ATP binding site [chemical binding]; other site 644651007710 Q-loop/lid; other site 644651007711 ABC transporter signature motif; other site 644651007712 Walker B; other site 644651007713 D-loop; other site 644651007714 H-loop/switch region; other site 644651007715 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651007716 Walker A/P-loop; other site 644651007717 ATP binding site [chemical binding]; other site 644651007718 Q-loop/lid; other site 644651007719 ABC transporter signature motif; other site 644651007720 Walker B; other site 644651007721 D-loop; other site 644651007722 H-loop/switch region; other site 644651007723 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644651007724 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644651007725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007726 dimer interface [polypeptide binding]; other site 644651007727 conserved gate region; other site 644651007728 ABC-ATPase subunit interface; other site 644651007729 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644651007730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651007731 dimer interface [polypeptide binding]; other site 644651007732 conserved gate region; other site 644651007733 putative PBP binding loops; other site 644651007734 ABC-ATPase subunit interface; other site 644651007735 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644651007736 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 644651007737 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 644651007738 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 644651007739 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 644651007740 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 644651007741 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 644651007742 potential frameshift: common BLAST hit: gi|207858042|ref|YP_002244693.1| transposase 644651007743 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651007744 Transposase; Region: HTH_Tnp_1; pfam01527 644651007745 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 644651007746 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 644651007747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651007748 FeS/SAM binding site; other site 644651007749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651007750 Transposase; Region: HTH_Tnp_1; pfam01527 644651007751 putative transposase OrfB; Reviewed; Region: PHA02517 644651007752 HTH-like domain; Region: HTH_21; pfam13276 644651007753 Integrase core domain; Region: rve; pfam00665 644651007754 Integrase core domain; Region: rve_3; pfam13683 644651007755 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 644651007756 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651007757 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651007758 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 644651007759 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 644651007760 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 644651007761 homodimer interface [polypeptide binding]; other site 644651007762 NADP binding site [chemical binding]; other site 644651007763 substrate binding site [chemical binding]; other site 644651007764 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651007765 RNA binding surface [nucleotide binding]; other site 644651007766 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 644651007767 substrate binding site [chemical binding]; other site 644651007768 structural Zn binding site [ion binding]; other site 644651007769 tetramer interface [polypeptide binding]; other site 644651007770 NAD binding site [chemical binding]; other site 644651007771 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 644651007772 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644651007773 active site 644651007774 HIGH motif; other site 644651007775 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644651007776 KMSKS motif; other site 644651007777 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 644651007778 tRNA binding surface [nucleotide binding]; other site 644651007779 anticodon binding site; other site 644651007780 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 644651007781 substrate binding site [chemical binding]; other site 644651007782 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 644651007783 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644651007784 putative active site [active] 644651007785 putative metal binding site [ion binding]; other site 644651007786 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 644651007787 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 644651007788 ATP-grasp domain; Region: ATP-grasp; pfam02222 644651007789 FtsX-like permease family; Region: FtsX; pfam02687 644651007790 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 644651007791 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644651007792 Walker A/P-loop; other site 644651007793 ATP binding site [chemical binding]; other site 644651007794 Q-loop/lid; other site 644651007795 ABC transporter signature motif; other site 644651007796 Walker B; other site 644651007797 D-loop; other site 644651007798 H-loop/switch region; other site 644651007799 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 644651007800 active site 644651007801 catalytic triad [active] 644651007802 oxyanion hole [active] 644651007803 switch loop; other site 644651007804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651007805 NAD(P) binding site [chemical binding]; other site 644651007806 active site 644651007807 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 644651007808 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 644651007809 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 644651007810 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 644651007811 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 644651007812 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 644651007813 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 644651007814 DNA binding residues [nucleotide binding] 644651007815 dimer interface [polypeptide binding]; other site 644651007816 copper binding site [ion binding]; other site 644651007817 copper exporting ATPase; Provisional; Region: copA; PRK10671 644651007818 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644651007819 metal-binding site [ion binding] 644651007820 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644651007821 metal-binding site [ion binding] 644651007822 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644651007823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651007824 motif II; other site 644651007825 TraB family; Region: TraB; cl12050 644651007826 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 644651007827 putative deacylase active site [active] 644651007828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651007829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651007830 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644651007831 dimerization interface [polypeptide binding]; other site 644651007832 Predicted membrane protein [Function unknown]; Region: COG4125 644651007833 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 644651007834 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 644651007835 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 644651007836 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 644651007837 active site 644651007838 metal binding site [ion binding]; metal-binding site 644651007839 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 644651007840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651007841 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644651007842 putative substrate translocation pore; other site 644651007843 putative cation:proton antiport protein; Provisional; Region: PRK10669 644651007844 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 644651007845 TrkA-N domain; Region: TrkA_N; pfam02254 644651007846 inosine/guanosine kinase; Provisional; Region: PRK15074 644651007847 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644651007848 ferrochelatase; Reviewed; Region: hemH; PRK00035 644651007849 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 644651007850 C-terminal domain interface [polypeptide binding]; other site 644651007851 active site 644651007852 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 644651007853 active site 644651007854 N-terminal domain interface [polypeptide binding]; other site 644651007855 adenylate kinase; Reviewed; Region: adk; PRK00279 644651007856 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 644651007857 AMP-binding site [chemical binding]; other site 644651007858 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 644651007859 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644651007860 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651007861 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 644651007862 nudix motif; other site 644651007863 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 644651007864 Ligand Binding Site [chemical binding]; other site 644651007865 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 644651007866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651007867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644651007868 dimerization interface [polypeptide binding]; other site 644651007869 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644651007870 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 644651007871 P-loop; other site 644651007872 Magnesium ion binding site [ion binding]; other site 644651007873 heat shock protein 90; Provisional; Region: PRK05218 644651007874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651007875 ATP binding site [chemical binding]; other site 644651007876 Mg2+ binding site [ion binding]; other site 644651007877 G-X-G motif; other site 644651007878 recombination protein RecR; Reviewed; Region: recR; PRK00076 644651007879 RecR protein; Region: RecR; pfam02132 644651007880 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 644651007881 putative active site [active] 644651007882 putative metal-binding site [ion binding]; other site 644651007883 tetramer interface [polypeptide binding]; other site 644651007884 hypothetical protein; Validated; Region: PRK00153 644651007885 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 644651007886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651007887 Walker A motif; other site 644651007888 ATP binding site [chemical binding]; other site 644651007889 Walker B motif; other site 644651007890 arginine finger; other site 644651007891 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 644651007892 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 644651007893 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 644651007894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651007895 active site 644651007896 hypothetical protein; Provisional; Region: PRK10527 644651007897 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 644651007898 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 644651007899 hypothetical protein; Provisional; Region: PRK11038 644651007900 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 644651007901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651007902 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 644651007903 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 644651007904 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 644651007905 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651007906 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 644651007907 Protein export membrane protein; Region: SecD_SecF; cl14618 644651007908 Protein export membrane protein; Region: SecD_SecF; cl14618 644651007909 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 644651007910 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 644651007911 Hha toxicity attenuator; Provisional; Region: PRK10667 644651007912 gene expression modulator; Provisional; Region: PRK10945 644651007913 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 644651007914 DNA binding site [nucleotide binding] 644651007915 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 644651007916 active site 644651007917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 644651007918 acyl-CoA thioesterase II; Provisional; Region: PRK10526 644651007919 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 644651007920 active site 644651007921 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 644651007922 catalytic triad [active] 644651007923 dimer interface [polypeptide binding]; other site 644651007924 ammonium transporter; Provisional; Region: PRK10666 644651007925 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 644651007926 Nitrogen regulatory protein P-II; Region: P-II; smart00938 644651007927 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 644651007928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644651007929 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 644651007930 Walker A/P-loop; other site 644651007931 ATP binding site [chemical binding]; other site 644651007932 Q-loop/lid; other site 644651007933 ABC transporter signature motif; other site 644651007934 Walker B; other site 644651007935 D-loop; other site 644651007936 H-loop/switch region; other site 644651007937 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 644651007938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644651007939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651007940 Walker A/P-loop; other site 644651007941 ATP binding site [chemical binding]; other site 644651007942 Q-loop/lid; other site 644651007943 ABC transporter signature motif; other site 644651007944 Walker B; other site 644651007945 D-loop; other site 644651007946 H-loop/switch region; other site 644651007947 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 644651007948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644651007949 putative DNA binding site [nucleotide binding]; other site 644651007950 putative Zn2+ binding site [ion binding]; other site 644651007951 AsnC family; Region: AsnC_trans_reg; pfam01037 644651007952 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 644651007953 EamA-like transporter family; Region: EamA; pfam00892 644651007954 EamA-like transporter family; Region: EamA; pfam00892 644651007955 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 644651007956 Ligand Binding Site [chemical binding]; other site 644651007957 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644651007958 active site 644651007959 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 644651007960 periplasmic folding chaperone; Provisional; Region: PRK10788 644651007961 SurA N-terminal domain; Region: SurA_N_3; cl07813 644651007962 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 644651007963 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 644651007964 IHF dimer interface [polypeptide binding]; other site 644651007965 IHF - DNA interface [nucleotide binding]; other site 644651007966 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 644651007967 Found in ATP-dependent protease La (LON); Region: LON; smart00464 644651007968 Found in ATP-dependent protease La (LON); Region: LON; smart00464 644651007969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651007970 Walker A motif; other site 644651007971 ATP binding site [chemical binding]; other site 644651007972 Walker B motif; other site 644651007973 arginine finger; other site 644651007974 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 644651007975 potential frameshift: common BLAST hit: gi|259909251|ref|YP_002649607.1| ATP-dependent protease ATP-binding subunit ClpX 644651007976 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644651007977 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 644651007978 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 644651007979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651007980 Walker A motif; other site 644651007981 ATP binding site [chemical binding]; other site 644651007982 Walker B motif; other site 644651007983 Clp protease; Region: CLP_protease; pfam00574 644651007984 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 644651007985 oligomer interface [polypeptide binding]; other site 644651007986 active site residues [active] 644651007987 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 644651007988 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 644651007989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651007990 Walker A motif; other site 644651007991 ATP binding site [chemical binding]; other site 644651007992 Walker B motif; other site 644651007993 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644651007994 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 644651007995 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 644651007996 oligomer interface [polypeptide binding]; other site 644651007997 active site residues [active] 644651007998 trigger factor; Provisional; Region: tig; PRK01490 644651007999 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644651008000 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 644651008001 transcriptional regulator BolA; Provisional; Region: PRK11628 644651008002 hypothetical protein; Provisional; Region: PRK11627 644651008003 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 644651008004 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 644651008005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651008006 putative substrate translocation pore; other site 644651008007 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 644651008008 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 644651008009 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 644651008010 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 644651008011 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 644651008012 D-pathway; other site 644651008013 Putative ubiquinol binding site [chemical binding]; other site 644651008014 Low-spin heme (heme b) binding site [chemical binding]; other site 644651008015 Putative water exit pathway; other site 644651008016 Binuclear center (heme o3/CuB) [ion binding]; other site 644651008017 K-pathway; other site 644651008018 Putative proton exit pathway; other site 644651008019 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 644651008020 Subunit I/III interface [polypeptide binding]; other site 644651008021 Subunit III/IV interface [polypeptide binding]; other site 644651008022 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 644651008023 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 644651008024 UbiA prenyltransferase family; Region: UbiA; pfam01040 644651008025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651008026 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644651008027 putative substrate translocation pore; other site 644651008028 Transposase; Region: HTH_Tnp_1; pfam01527 644651008029 Winged helix-turn helix; Region: HTH_29; pfam13551 644651008030 Helix-turn-helix domain; Region: HTH_28; pfam13518 644651008031 Integrase core domain; Region: rve; pfam00665 644651008032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 644651008033 Integrase core domain; Region: rve_3; pfam13683 644651008034 potential frameshift: common BLAST hit: gi|385786496|ref|YP_005817605.1| transposase 644651008035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651008036 MULE transposase domain; Region: MULE; pfam10551 644651008037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651008038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 644651008039 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 644651008040 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 644651008041 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 644651008042 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 644651008043 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 644651008044 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 644651008045 conserved cys residue [active] 644651008046 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 644651008047 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 644651008048 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 644651008049 Ligand Binding Site [chemical binding]; other site 644651008050 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 644651008051 active site residue [active] 644651008052 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 644651008053 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644651008054 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644651008055 substrate binding pocket [chemical binding]; other site 644651008056 chain length determination region; other site 644651008057 substrate-Mg2+ binding site; other site 644651008058 catalytic residues [active] 644651008059 aspartate-rich region 1; other site 644651008060 active site lid residues [active] 644651008061 aspartate-rich region 2; other site 644651008062 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 644651008063 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 644651008064 TPP-binding site; other site 644651008065 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644651008066 PYR/PP interface [polypeptide binding]; other site 644651008067 dimer interface [polypeptide binding]; other site 644651008068 TPP binding site [chemical binding]; other site 644651008069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644651008070 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 644651008071 tetramer interfaces [polypeptide binding]; other site 644651008072 binuclear metal-binding site [ion binding]; other site 644651008073 thiamine monophosphate kinase; Provisional; Region: PRK05731 644651008074 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 644651008075 ATP binding site [chemical binding]; other site 644651008076 dimerization interface [polypeptide binding]; other site 644651008077 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 644651008078 putative RNA binding site [nucleotide binding]; other site 644651008079 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 644651008080 homopentamer interface [polypeptide binding]; other site 644651008081 active site 644651008082 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 644651008083 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 644651008084 catalytic motif [active] 644651008085 Zn binding site [ion binding]; other site 644651008086 RibD C-terminal domain; Region: RibD_C; cl17279 644651008087 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 644651008088 ATP cone domain; Region: ATP-cone; pfam03477 644651008089 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 644651008090 BON domain; Region: BON; pfam04972 644651008091 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644651008092 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 644651008093 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 644651008094 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 644651008095 Protein export membrane protein; Region: SecD_SecF; pfam02355 644651008096 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 644651008097 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 644651008098 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 644651008099 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 644651008100 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 644651008101 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 644651008102 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 644651008103 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 644651008104 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 644651008105 Protein of unknown function, DUF479; Region: DUF479; cl01203 644651008106 peroxidase; Provisional; Region: PRK15000 644651008107 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 644651008108 dimer interface [polypeptide binding]; other site 644651008109 decamer (pentamer of dimers) interface [polypeptide binding]; other site 644651008110 catalytic triad [active] 644651008111 peroxidatic and resolving cysteines [active] 644651008112 putative proline-specific permease; Provisional; Region: proY; PRK10580 644651008113 Spore germination protein; Region: Spore_permease; cl17796 644651008114 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 644651008115 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 644651008116 substrate binding site [chemical binding]; other site 644651008117 THF binding site; other site 644651008118 zinc-binding site [ion binding]; other site 644651008119 PBP superfamily domain; Region: PBP_like_2; cl17296 644651008120 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 644651008121 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 644651008122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651008123 putative active site [active] 644651008124 heme pocket [chemical binding]; other site 644651008125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651008126 dimer interface [polypeptide binding]; other site 644651008127 phosphorylation site [posttranslational modification] 644651008128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651008129 ATP binding site [chemical binding]; other site 644651008130 Mg2+ binding site [ion binding]; other site 644651008131 G-X-G motif; other site 644651008132 transcriptional regulator PhoB; Provisional; Region: PRK10161 644651008133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651008134 active site 644651008135 phosphorylation site [posttranslational modification] 644651008136 intermolecular recognition site; other site 644651008137 dimerization interface [polypeptide binding]; other site 644651008138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651008139 DNA binding site [nucleotide binding] 644651008140 exonuclease subunit SbcD; Provisional; Region: PRK10966 644651008141 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 644651008142 active site 644651008143 metal binding site [ion binding]; metal-binding site 644651008144 DNA binding site [nucleotide binding] 644651008145 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 644651008146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651008147 Walker A/P-loop; other site 644651008148 ATP binding site [chemical binding]; other site 644651008149 Q-loop/lid; other site 644651008150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651008151 ABC transporter signature motif; other site 644651008152 Walker B; other site 644651008153 D-loop; other site 644651008154 H-loop/switch region; other site 644651008155 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 644651008156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 644651008157 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 644651008158 Helix-turn-helix domain; Region: HTH_18; pfam12833 644651008159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651008160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651008161 H-loop/switch region; other site 644651008162 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 644651008163 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 644651008164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651008165 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 644651008166 active site 644651008167 substrate binding site [chemical binding]; other site 644651008168 Phosphotransferase enzyme family; Region: APH; pfam01636 644651008169 ATP binding site [chemical binding]; other site 644651008170 ethanolamine permease; Region: 2A0305; TIGR00908 644651008171 recombination associated protein; Reviewed; Region: rdgC; PRK00321 644651008172 hypothetical protein; Provisional; Region: PRK10579 644651008173 AroM protein; Region: AroM; cl17601 644651008174 hypothetical protein; Provisional; Region: PRK10380 644651008175 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 644651008176 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 644651008177 ADP binding site [chemical binding]; other site 644651008178 magnesium binding site [ion binding]; other site 644651008179 putative shikimate binding site; other site 644651008180 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 644651008181 hypothetical protein; Validated; Region: PRK00124 644651008182 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 644651008183 pyrroline-5-carboxylate reductase; Region: PLN02688 644651008184 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 644651008185 psiF repeat; Region: PsiF_repeat; pfam07769 644651008186 psiF repeat; Region: PsiF_repeat; pfam07769 644651008187 potential frameshift: common BLAST hit: gi|292898645|ref|YP_003538014.1| beta-galactosidase 644651008188 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 644651008189 potential frameshift: common BLAST hit: gi|292487398|ref|YP_003530270.1| beta-galactosidase 644651008190 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 644651008191 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 644651008192 potential frameshift: common BLAST hit: gi|385787504|ref|YP_005818613.1| beta-galactosidase 644651008193 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 644651008194 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 644651008195 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 644651008196 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644651008197 DNA-binding site [nucleotide binding]; DNA binding site 644651008198 RNA-binding motif; other site 644651008199 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 644651008200 CAAX protease self-immunity; Region: Abi; pfam02517 644651008201 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644651008202 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 644651008203 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644651008204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651008205 putative PBP binding loops; other site 644651008206 dimer interface [polypeptide binding]; other site 644651008207 ABC-ATPase subunit interface; other site 644651008208 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644651008209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651008210 dimer interface [polypeptide binding]; other site 644651008211 conserved gate region; other site 644651008212 putative PBP binding loops; other site 644651008213 ABC-ATPase subunit interface; other site 644651008214 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 644651008215 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651008216 Walker A/P-loop; other site 644651008217 ATP binding site [chemical binding]; other site 644651008218 Q-loop/lid; other site 644651008219 ABC transporter signature motif; other site 644651008220 Walker B; other site 644651008221 D-loop; other site 644651008222 H-loop/switch region; other site 644651008223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651008224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644651008225 Walker A/P-loop; other site 644651008226 ATP binding site [chemical binding]; other site 644651008227 Q-loop/lid; other site 644651008228 ABC transporter signature motif; other site 644651008229 Walker B; other site 644651008230 D-loop; other site 644651008231 H-loop/switch region; other site 644651008232 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 644651008233 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644651008234 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 644651008235 Acyltransferase family; Region: Acyl_transf_3; pfam01757 644651008236 potential frameshift: common BLAST hit: gi|292898629|ref|YP_003537998.1| methyltransferase 644651008237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 644651008238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 644651008239 anti-RssB factor; Provisional; Region: PRK10244 644651008240 chromosome condensation membrane protein; Provisional; Region: PRK14196 644651008241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 644651008242 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 644651008243 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 644651008244 oligomeric interface; other site 644651008245 putative active site [active] 644651008246 homodimer interface [polypeptide binding]; other site 644651008247 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 644651008248 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 644651008249 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 644651008250 putative catalytic cysteine [active] 644651008251 gamma-glutamyl kinase; Provisional; Region: PRK05429 644651008252 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 644651008253 nucleotide binding site [chemical binding]; other site 644651008254 homotetrameric interface [polypeptide binding]; other site 644651008255 putative phosphate binding site [ion binding]; other site 644651008256 putative allosteric binding site; other site 644651008257 PUA domain; Region: PUA; pfam01472 644651008258 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 644651008259 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 644651008260 trimer interface [polypeptide binding]; other site 644651008261 eyelet of channel; other site 644651008262 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 644651008263 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 644651008264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651008265 active site 644651008266 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 644651008267 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 644651008268 metal binding site [ion binding]; metal-binding site 644651008269 dimer interface [polypeptide binding]; other site 644651008270 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 644651008271 active site 644651008272 DNA polymerase IV; Validated; Region: PRK02406 644651008273 DNA binding site [nucleotide binding] 644651008274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 644651008275 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 644651008276 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 644651008277 putative active site [active] 644651008278 putative dimer interface [polypeptide binding]; other site 644651008279 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 644651008280 dimer interface [polypeptide binding]; other site 644651008281 active site 644651008282 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 644651008283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 644651008284 active site 644651008285 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 644651008286 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 644651008287 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 644651008288 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 644651008289 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 644651008290 Cupin domain; Region: Cupin_2; cl17218 644651008291 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 644651008292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651008293 motif II; other site 644651008294 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 644651008295 intersubunit interface [polypeptide binding]; other site 644651008296 active site 644651008297 Zn2+ binding site [ion binding]; other site 644651008298 Transposase, Mutator family; Region: Transposase_mut; pfam00872 644651008299 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 644651008300 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 644651008301 methionine aminotransferase; Validated; Region: PRK09082 644651008302 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651008303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651008304 homodimer interface [polypeptide binding]; other site 644651008305 catalytic residue [active] 644651008306 C-N hydrolase family amidase; Provisional; Region: PRK10438 644651008307 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 644651008308 putative active site [active] 644651008309 catalytic triad [active] 644651008310 dimer interface [polypeptide binding]; other site 644651008311 multimer interface [polypeptide binding]; other site 644651008312 xanthine permease; Region: pbuX; TIGR03173 644651008313 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 644651008314 active site 644651008315 homotetramer interface [polypeptide binding]; other site 644651008316 OHCU decarboxylase; Region: UraD_2; TIGR03180 644651008317 allantoate amidohydrolase; Reviewed; Region: PRK09290 644651008318 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 644651008319 active site 644651008320 metal binding site [ion binding]; metal-binding site 644651008321 dimer interface [polypeptide binding]; other site 644651008322 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 644651008323 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651008324 catalytic residue [active] 644651008325 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644651008326 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644651008327 Walker A/P-loop; other site 644651008328 ATP binding site [chemical binding]; other site 644651008329 Q-loop/lid; other site 644651008330 ABC transporter signature motif; other site 644651008331 Walker B; other site 644651008332 D-loop; other site 644651008333 H-loop/switch region; other site 644651008334 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651008335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651008336 dimer interface [polypeptide binding]; other site 644651008337 conserved gate region; other site 644651008338 putative PBP binding loops; other site 644651008339 ABC-ATPase subunit interface; other site 644651008340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644651008341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651008342 dimer interface [polypeptide binding]; other site 644651008343 conserved gate region; other site 644651008344 putative PBP binding loops; other site 644651008345 ABC-ATPase subunit interface; other site 644651008346 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644651008347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651008348 substrate binding pocket [chemical binding]; other site 644651008349 membrane-bound complex binding site; other site 644651008350 hinge residues; other site 644651008351 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644651008352 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644651008353 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 644651008354 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 644651008355 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 644651008356 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 644651008357 amidase; Provisional; Region: PRK09201 644651008358 Amidase; Region: Amidase; cl11426 644651008359 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 644651008360 Uncharacterized conserved protein [Function unknown]; Region: COG4127 644651008361 Restriction endonuclease; Region: Mrr_cat; pfam04471 644651008362 DNA methylase; Region: N6_N4_Mtase; cl17433 644651008363 DNA methylase; Region: N6_N4_Mtase; cl17433 644651008364 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 644651008365 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 644651008366 active site 644651008367 catalytic site [active] 644651008368 tetramer interface [polypeptide binding]; other site 644651008369 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 644651008370 Transcriptional regulators [Transcription]; Region: GntR; COG1802 644651008371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651008372 DNA-binding site [nucleotide binding]; DNA binding site 644651008373 FCD domain; Region: FCD; pfam07729 644651008374 potential frameshift: common BLAST hit: gi|385787434|ref|YP_005818543.1| Putative permease 644651008375 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 644651008376 Na binding site [ion binding]; other site 644651008377 putative substrate binding site [chemical binding]; other site 644651008378 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644651008379 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 644651008380 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 644651008381 active site 644651008382 catalytic site [active] 644651008383 substrate binding site [chemical binding]; other site 644651008384 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 644651008385 RNA/DNA hybrid binding site [nucleotide binding]; other site 644651008386 active site 644651008387 Methyltransferase domain; Region: Methyltransf_11; pfam08241 644651008388 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644651008389 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 644651008390 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644651008391 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644651008392 catalytic residue [active] 644651008393 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644651008394 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644651008395 Methyltransferase domain; Region: Methyltransf_31; pfam13847 644651008396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651008397 S-adenosylmethionine binding site [chemical binding]; other site 644651008398 hypothetical protein; Provisional; Region: PRK05421 644651008399 putative catalytic site [active] 644651008400 putative metal binding site [ion binding]; other site 644651008401 putative phosphate binding site [ion binding]; other site 644651008402 putative catalytic site [active] 644651008403 putative phosphate binding site [ion binding]; other site 644651008404 putative metal binding site [ion binding]; other site 644651008405 protein disaggregation chaperone; Provisional; Region: PRK10865 644651008406 Clp amino terminal domain; Region: Clp_N; pfam02861 644651008407 Clp amino terminal domain; Region: Clp_N; pfam02861 644651008408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651008409 Walker A motif; other site 644651008410 ATP binding site [chemical binding]; other site 644651008411 Walker B motif; other site 644651008412 arginine finger; other site 644651008413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651008414 Walker A motif; other site 644651008415 ATP binding site [chemical binding]; other site 644651008416 Walker B motif; other site 644651008417 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 644651008418 hypothetical protein; Provisional; Region: PRK10723 644651008419 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 644651008420 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 644651008421 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651008422 RNA binding surface [nucleotide binding]; other site 644651008423 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644651008424 active site 644651008425 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 644651008426 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 644651008427 30S subunit binding site; other site 644651008428 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 644651008429 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 644651008430 Prephenate dehydratase; Region: PDT; pfam00800 644651008431 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 644651008432 putative L-Phe binding site [chemical binding]; other site 644651008433 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 644651008434 Chorismate mutase type II; Region: CM_2; cl00693 644651008435 prephenate dehydrogenase; Validated; Region: PRK08507 644651008436 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 644651008437 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 644651008438 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 644651008439 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644651008440 hypothetical protein; Validated; Region: PRK06186 644651008441 conserved cys residue [active] 644651008442 PPR repeat family; Region: PPR_2; pfam13041 644651008443 PPR repeat family; Region: PPR_2; pfam13041 644651008444 potential protein location (hypothetical protein) that overlaps protein (Pentatricopeptide repeat-containing protein) 644651008445 Integrase core domain; Region: rve_3; cl15866 644651008446 PPR repeat family; Region: PPR_2; pfam13041 644651008447 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 644651008448 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 644651008449 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 644651008450 RimM N-terminal domain; Region: RimM; pfam01782 644651008451 PRC-barrel domain; Region: PRC; pfam05239 644651008452 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 644651008453 signal recognition particle protein; Provisional; Region: PRK10867 644651008454 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 644651008455 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 644651008456 P loop; other site 644651008457 GTP binding site [chemical binding]; other site 644651008458 Signal peptide binding domain; Region: SRP_SPB; pfam02978 644651008459 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 644651008460 hypothetical protein; Provisional; Region: PRK11573 644651008461 Domain of unknown function DUF21; Region: DUF21; pfam01595 644651008462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644651008463 Transporter associated domain; Region: CorC_HlyC; smart01091 644651008464 S-ribosylhomocysteinase; Provisional; Region: PRK02260 644651008465 glutamate--cysteine ligase; Provisional; Region: PRK02107 644651008466 Predicted membrane protein [Function unknown]; Region: COG1238 644651008467 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 644651008468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651008469 motif II; other site 644651008470 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 644651008471 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 644651008472 motif 1; other site 644651008473 active site 644651008474 motif 2; other site 644651008475 motif 3; other site 644651008476 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 644651008477 DHHA1 domain; Region: DHHA1; pfam02272 644651008478 recombination regulator RecX; Reviewed; Region: recX; PRK00117 644651008479 recombinase A; Provisional; Region: recA; PRK09354 644651008480 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 644651008481 hexamer interface [polypeptide binding]; other site 644651008482 Walker A motif; other site 644651008483 ATP binding site [chemical binding]; other site 644651008484 Walker B motif; other site 644651008485 hypothetical protein; Validated; Region: PRK03661 644651008486 Transglycosylase SLT domain; Region: SLT_2; pfam13406 644651008487 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644651008488 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644651008489 catalytic residue [active] 644651008490 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 644651008491 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 644651008492 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 644651008493 catalytic residues [active] 644651008494 hinge region; other site 644651008495 alpha helical domain; other site 644651008496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651008497 Transposase; Region: HTH_Tnp_1; pfam01527 644651008498 putative transposase OrfB; Reviewed; Region: PHA02517 644651008499 HTH-like domain; Region: HTH_21; pfam13276 644651008500 Integrase core domain; Region: rve; pfam00665 644651008501 Integrase core domain; Region: rve_3; pfam13683 644651008502 Fic/DOC family; Region: Fic; pfam02661 644651008503 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 644651008504 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 644651008505 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 644651008506 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 644651008507 Methyltransferase domain; Region: Methyltransf_26; pfam13659 644651008508 Methyltransferase domain; Region: Methyltransf_26; pfam13659 644651008509 TIGR02687 family protein; Region: TIGR02687 644651008510 PglZ domain; Region: PglZ; pfam08665 644651008511 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 644651008512 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 644651008513 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 644651008514 putative transposase OrfB; Reviewed; Region: PHA02517 644651008515 HTH-like domain; Region: HTH_21; pfam13276 644651008516 Integrase core domain; Region: rve; pfam00665 644651008517 Integrase core domain; Region: rve_3; pfam13683 644651008518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644651008519 Transposase; Region: HTH_Tnp_1; pfam01527 644651008520 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 644651008521 MutS domain I; Region: MutS_I; pfam01624 644651008522 MutS domain II; Region: MutS_II; pfam05188 644651008523 MutS domain III; Region: MutS_III; pfam05192 644651008524 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 644651008525 Walker A/P-loop; other site 644651008526 ATP binding site [chemical binding]; other site 644651008527 Q-loop/lid; other site 644651008528 ABC transporter signature motif; other site 644651008529 Walker B; other site 644651008530 D-loop; other site 644651008531 H-loop/switch region; other site 644651008532 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 644651008533 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 644651008534 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644651008535 Peptidase family M23; Region: Peptidase_M23; pfam01551 644651008536 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 644651008537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651008538 S-adenosylmethionine binding site [chemical binding]; other site 644651008539 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 644651008540 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 644651008541 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 644651008542 Permutation of conserved domain; other site 644651008543 active site 644651008544 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 644651008545 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 644651008546 homotrimer interaction site [polypeptide binding]; other site 644651008547 zinc binding site [ion binding]; other site 644651008548 CDP-binding sites; other site 644651008549 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 644651008550 substrate binding site; other site 644651008551 dimer interface; other site 644651008552 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 644651008553 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 644651008554 hypothetical protein; Provisional; Region: PRK10726 644651008555 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 644651008556 ligand-binding site [chemical binding]; other site 644651008557 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 644651008558 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 644651008559 CysD dimerization site [polypeptide binding]; other site 644651008560 G1 box; other site 644651008561 putative GEF interaction site [polypeptide binding]; other site 644651008562 GTP/Mg2+ binding site [chemical binding]; other site 644651008563 Switch I region; other site 644651008564 G2 box; other site 644651008565 G3 box; other site 644651008566 Switch II region; other site 644651008567 G4 box; other site 644651008568 G5 box; other site 644651008569 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 644651008570 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 644651008571 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 644651008572 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 644651008573 Active Sites [active] 644651008574 siroheme synthase; Provisional; Region: cysG; PRK10637 644651008575 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 644651008576 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 644651008577 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 644651008578 active site 644651008579 SAM binding site [chemical binding]; other site 644651008580 homodimer interface [polypeptide binding]; other site 644651008581 YCII-related domain; Region: YCII; cl00999 644651008582 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 644651008583 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 644651008584 Active Sites [active] 644651008585 sulfite reductase subunit beta; Provisional; Region: PRK13504 644651008586 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 644651008587 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 644651008588 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 644651008589 Flavodoxin; Region: Flavodoxin_1; pfam00258 644651008590 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 644651008591 FAD binding pocket [chemical binding]; other site 644651008592 FAD binding motif [chemical binding]; other site 644651008593 catalytic residues [active] 644651008594 NAD binding pocket [chemical binding]; other site 644651008595 phosphate binding motif [ion binding]; other site 644651008596 beta-alpha-beta structure motif; other site 644651008597 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 644651008598 active site 644651008599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651008600 dimer interface [polypeptide binding]; other site 644651008601 conserved gate region; other site 644651008602 putative PBP binding loops; other site 644651008603 ABC-ATPase subunit interface; other site 644651008604 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644651008605 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644651008606 Walker A/P-loop; other site 644651008607 ATP binding site [chemical binding]; other site 644651008608 Q-loop/lid; other site 644651008609 ABC transporter signature motif; other site 644651008610 Walker B; other site 644651008611 D-loop; other site 644651008612 H-loop/switch region; other site 644651008613 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644651008614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651008615 substrate binding pocket [chemical binding]; other site 644651008616 membrane-bound complex binding site; other site 644651008617 hinge residues; other site 644651008618 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 644651008619 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 644651008620 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644651008621 enolase; Provisional; Region: eno; PRK00077 644651008622 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 644651008623 dimer interface [polypeptide binding]; other site 644651008624 metal binding site [ion binding]; metal-binding site 644651008625 substrate binding pocket [chemical binding]; other site 644651008626 CTP synthetase; Validated; Region: pyrG; PRK05380 644651008627 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 644651008628 Catalytic site [active] 644651008629 active site 644651008630 UTP binding site [chemical binding]; other site 644651008631 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 644651008632 active site 644651008633 putative oxyanion hole; other site 644651008634 catalytic triad [active] 644651008635 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 644651008636 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 644651008637 homodimer interface [polypeptide binding]; other site 644651008638 metal binding site [ion binding]; metal-binding site 644651008639 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 644651008640 homodimer interface [polypeptide binding]; other site 644651008641 active site 644651008642 putative chemical substrate binding site [chemical binding]; other site 644651008643 metal binding site [ion binding]; metal-binding site 644651008644 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 644651008645 HD domain; Region: HD_4; pfam13328 644651008646 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 644651008647 synthetase active site [active] 644651008648 NTP binding site [chemical binding]; other site 644651008649 metal binding site [ion binding]; metal-binding site 644651008650 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 644651008651 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 644651008652 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 644651008653 TRAM domain; Region: TRAM; pfam01938 644651008654 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 644651008655 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 644651008656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651008657 dimerization interface [polypeptide binding]; other site 644651008658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651008659 dimer interface [polypeptide binding]; other site 644651008660 phosphorylation site [posttranslational modification] 644651008661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651008662 ATP binding site [chemical binding]; other site 644651008663 Mg2+ binding site [ion binding]; other site 644651008664 G-X-G motif; other site 644651008665 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 644651008666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651008667 active site 644651008668 phosphorylation site [posttranslational modification] 644651008669 intermolecular recognition site; other site 644651008670 dimerization interface [polypeptide binding]; other site 644651008671 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 644651008672 putative binding surface; other site 644651008673 active site 644651008674 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 644651008675 flavodoxin; Provisional; Region: PRK08105 644651008676 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 644651008677 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644651008678 probable active site [active] 644651008679 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 644651008680 SecY interacting protein Syd; Provisional; Region: PRK04968 644651008681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 644651008682 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 644651008683 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 644651008684 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 644651008685 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 644651008686 flap endonuclease-like protein; Provisional; Region: PRK09482 644651008687 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 644651008688 active site 644651008689 metal binding site 1 [ion binding]; metal-binding site 644651008690 putative 5' ssDNA interaction site; other site 644651008691 metal binding site 3; metal-binding site 644651008692 metal binding site 2 [ion binding]; metal-binding site 644651008693 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 644651008694 putative DNA binding site [nucleotide binding]; other site 644651008695 putative metal binding site [ion binding]; other site 644651008696 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 644651008697 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 644651008698 hypothetical protein; Provisional; Region: PRK10873 644651008699 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 644651008700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651008701 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 644651008702 dimerization interface [polypeptide binding]; other site 644651008703 substrate binding pocket [chemical binding]; other site 644651008704 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 644651008705 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 644651008706 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 644651008707 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651008708 catalytic residue [active] 644651008709 Fe-S metabolism associated domain; Region: SufE; cl00951 644651008710 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 644651008711 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 644651008712 putative ATP binding site [chemical binding]; other site 644651008713 putative substrate interface [chemical binding]; other site 644651008714 murein transglycosylase A; Provisional; Region: mltA; PRK11162 644651008715 MltA specific insert domain; Region: MltA; smart00925 644651008716 3D domain; Region: 3D; pfam06725 644651008717 AMIN domain; Region: AMIN; pfam11741 644651008718 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644651008719 active site 644651008720 metal binding site [ion binding]; metal-binding site 644651008721 N-acetylglutamate synthase; Validated; Region: PRK05279 644651008722 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 644651008723 putative feedback inhibition sensing region; other site 644651008724 putative nucleotide binding site [chemical binding]; other site 644651008725 putative substrate binding site [chemical binding]; other site 644651008726 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 644651008727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651008728 Coenzyme A binding pocket [chemical binding]; other site 644651008729 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 644651008730 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 644651008731 AAA domain; Region: AAA_30; pfam13604 644651008732 Family description; Region: UvrD_C_2; pfam13538 644651008733 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 644651008734 protease3; Provisional; Region: PRK15101 644651008735 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 644651008736 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644651008737 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644651008738 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 644651008739 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 644651008740 hypothetical protein; Provisional; Region: PRK10332 644651008741 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 644651008742 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 644651008743 hypothetical protein; Provisional; Region: PRK10557 644651008744 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 644651008745 hypothetical protein; Provisional; Region: PRK10506 644651008746 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 644651008747 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 644651008748 thymidylate synthase; Reviewed; Region: thyA; PRK01827 644651008749 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 644651008750 dimerization interface [polypeptide binding]; other site 644651008751 active site 644651008752 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 644651008753 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 644651008754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 644651008755 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 644651008756 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 644651008757 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 644651008758 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 644651008759 putative active site [active] 644651008760 Ap4A binding site [chemical binding]; other site 644651008761 nudix motif; other site 644651008762 putative metal binding site [ion binding]; other site 644651008763 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 644651008764 putative DNA-binding cleft [nucleotide binding]; other site 644651008765 putative DNA clevage site; other site 644651008766 molecular lever; other site 644651008767 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 644651008768 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 644651008769 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644651008770 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644651008771 active site 644651008772 catalytic tetrad [active] 644651008773 lysophospholipid transporter LplT; Provisional; Region: PRK11195 644651008774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651008775 putative substrate translocation pore; other site 644651008776 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 644651008777 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 644651008778 putative acyl-acceptor binding pocket; other site 644651008779 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 644651008780 acyl-activating enzyme (AAE) consensus motif; other site 644651008781 putative AMP binding site [chemical binding]; other site 644651008782 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 644651008783 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 644651008784 Protein export membrane protein; Region: SecD_SecF; cl14618 644651008785 potential protein location (hypothetical protein) that overlaps protein (mdtB) 644651008786 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 644651008787 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644651008788 E3 interaction surface; other site 644651008789 lipoyl attachment site [posttranslational modification]; other site 644651008790 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651008791 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 644651008792 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644651008793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644651008794 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 644651008795 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 644651008796 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 644651008797 haemagglutination activity domain; Region: Haemagg_act; pfam05860 644651008798 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 644651008799 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 644651008800 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 644651008801 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 644651008802 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 644651008803 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651008804 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 644651008805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651008806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651008807 non-specific DNA binding site [nucleotide binding]; other site 644651008808 salt bridge; other site 644651008809 sequence-specific DNA binding site [nucleotide binding]; other site 644651008810 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651008811 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651008812 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 644651008813 active site 644651008814 metal binding site [ion binding]; metal-binding site 644651008815 interdomain interaction site; other site 644651008816 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651008817 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651008818 active site 644651008819 DNA binding site [nucleotide binding] 644651008820 Int/Topo IB signature motif; other site 644651008821 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 644651008822 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 644651008823 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651008824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651008825 non-specific DNA binding site [nucleotide binding]; other site 644651008826 salt bridge; other site 644651008827 sequence-specific DNA binding site [nucleotide binding]; other site 644651008828 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651008829 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651008830 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 644651008831 active site 644651008832 metal binding site [ion binding]; metal-binding site 644651008833 interdomain interaction site; other site 644651008834 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651008835 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651008836 active site 644651008837 DNA binding site [nucleotide binding] 644651008838 Int/Topo IB signature motif; other site 644651008839 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 644651008840 Transposase; Region: HTH_Tnp_1; cl17663 644651008841 putative transposase OrfB; Reviewed; Region: PHA02517 644651008842 HTH-like domain; Region: HTH_21; pfam13276 644651008843 Integrase core domain; Region: rve; pfam00665 644651008844 Integrase core domain; Region: rve_2; pfam13333 644651008845 potential frameshift: common BLAST hit: gi|259909516|ref|YP_002649872.1| adhesin/hemagglutinin/hemolysin 644651008846 potential frameshift: common BLAST hit: gi|385787297|ref|YP_005818406.1| Putative adhesin/hemagglutinin/hemolysin 644651008847 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 644651008848 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 644651008849 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 644651008850 molybdopterin cofactor binding site [chemical binding]; other site 644651008851 substrate binding site [chemical binding]; other site 644651008852 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 644651008853 molybdopterin cofactor binding site; other site 644651008854 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 644651008855 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651008856 DNA binding site [nucleotide binding] 644651008857 domain linker motif; other site 644651008858 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 644651008859 dimerization interface (closed form) [polypeptide binding]; other site 644651008860 ligand binding site [chemical binding]; other site 644651008861 diaminopimelate decarboxylase; Provisional; Region: PRK11165 644651008862 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 644651008863 active site 644651008864 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644651008865 substrate binding site [chemical binding]; other site 644651008866 catalytic residues [active] 644651008867 dimer interface [polypeptide binding]; other site 644651008868 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 644651008869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651008870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644651008871 dimerization interface [polypeptide binding]; other site 644651008872 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 644651008873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651008874 putative substrate translocation pore; other site 644651008875 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644651008876 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 644651008877 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 644651008878 dimer interface [polypeptide binding]; other site 644651008879 putative anticodon binding site; other site 644651008880 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 644651008881 motif 1; other site 644651008882 active site 644651008883 motif 2; other site 644651008884 motif 3; other site 644651008885 peptide chain release factor 2; Provisional; Region: PRK08787 644651008886 This domain is found in peptide chain release factors; Region: PCRF; smart00937 644651008887 RF-1 domain; Region: RF-1; pfam00472 644651008888 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 644651008889 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 644651008890 DHH family; Region: DHH; pfam01368 644651008891 DHHA1 domain; Region: DHHA1; pfam02272 644651008892 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 644651008893 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 644651008894 dimerization domain [polypeptide binding]; other site 644651008895 dimer interface [polypeptide binding]; other site 644651008896 catalytic residues [active] 644651008897 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 644651008898 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 644651008899 active site 644651008900 Int/Topo IB signature motif; other site 644651008901 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 644651008902 EamA-like transporter family; Region: EamA; pfam00892 644651008903 flavodoxin FldB; Provisional; Region: PRK12359 644651008904 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 644651008905 hypothetical protein; Provisional; Region: PRK10878 644651008906 putative global regulator; Reviewed; Region: PRK09559 644651008907 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 644651008908 hemolysin; Provisional; Region: PRK15087 644651008909 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 644651008910 HD domain; Region: HD_3; pfam13023 644651008911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651008912 glycine dehydrogenase; Provisional; Region: PRK05367 644651008913 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 644651008914 tetramer interface [polypeptide binding]; other site 644651008915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651008916 catalytic residue [active] 644651008917 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 644651008918 tetramer interface [polypeptide binding]; other site 644651008919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651008920 catalytic residue [active] 644651008921 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 644651008922 lipoyl attachment site [posttranslational modification]; other site 644651008923 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 644651008924 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 644651008925 Abi-like protein; Region: Abi_2; pfam07751 644651008926 oxidoreductase; Provisional; Region: PRK08013 644651008927 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 644651008928 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 644651008929 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 644651008930 proline aminopeptidase P II; Provisional; Region: PRK10879 644651008931 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 644651008932 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 644651008933 active site 644651008934 hypothetical protein; Reviewed; Region: PRK01736 644651008935 Z-ring-associated protein; Provisional; Region: PRK10972 644651008936 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 644651008937 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 644651008938 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 644651008939 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 644651008940 ligand binding site [chemical binding]; other site 644651008941 NAD binding site [chemical binding]; other site 644651008942 tetramer interface [polypeptide binding]; other site 644651008943 catalytic site [active] 644651008944 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 644651008945 L-serine binding site [chemical binding]; other site 644651008946 ACT domain interface; other site 644651008947 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 644651008948 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644651008949 active site 644651008950 dimer interface [polypeptide binding]; other site 644651008951 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 644651008952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651008953 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 644651008954 putative dimerization interface [polypeptide binding]; other site 644651008955 oxidative stress defense protein; Provisional; Region: PRK11087 644651008956 Uncharacterized conserved protein [Function unknown]; Region: COG2968 644651008957 Homeodomain-like domain; Region: HTH_23; pfam13384 644651008958 Winged helix-turn helix; Region: HTH_29; pfam13551 644651008959 Homeodomain-like domain; Region: HTH_32; pfam13565 644651008960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651008961 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651008962 LysE type translocator; Region: LysE; cl00565 644651008963 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 644651008964 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 644651008965 inhibitor-cofactor binding pocket; inhibition site 644651008966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651008967 catalytic residue [active] 644651008968 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 644651008969 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644651008970 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644651008971 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644651008972 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 644651008973 Uncharacterized conserved protein [Function unknown]; Region: COG4095 644651008974 LysE type translocator; Region: LysE; cl00565 644651008975 mechanosensitive channel MscS; Provisional; Region: PRK10334 644651008976 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644651008977 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 644651008978 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 644651008979 active site 644651008980 intersubunit interface [polypeptide binding]; other site 644651008981 zinc binding site [ion binding]; other site 644651008982 Na+ binding site [ion binding]; other site 644651008983 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 644651008984 Phosphoglycerate kinase; Region: PGK; pfam00162 644651008985 substrate binding site [chemical binding]; other site 644651008986 hinge regions; other site 644651008987 ADP binding site [chemical binding]; other site 644651008988 catalytic site [active] 644651008989 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 644651008990 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 644651008991 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 644651008992 transketolase; Reviewed; Region: PRK12753 644651008993 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 644651008994 TPP-binding site [chemical binding]; other site 644651008995 dimer interface [polypeptide binding]; other site 644651008996 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644651008997 PYR/PP interface [polypeptide binding]; other site 644651008998 dimer interface [polypeptide binding]; other site 644651008999 TPP binding site [chemical binding]; other site 644651009000 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644651009001 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 644651009002 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 644651009003 agmatinase; Region: agmatinase; TIGR01230 644651009004 oligomer interface [polypeptide binding]; other site 644651009005 putative active site [active] 644651009006 Mn binding site [ion binding]; other site 644651009007 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 644651009008 arginine decarboxylase; Provisional; Region: PRK05354 644651009009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 644651009010 dimer interface [polypeptide binding]; other site 644651009011 active site 644651009012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644651009013 catalytic residues [active] 644651009014 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 644651009015 S-adenosylmethionine synthetase; Validated; Region: PRK05250 644651009016 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 644651009017 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 644651009018 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 644651009019 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 644651009020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651009021 putative substrate translocation pore; other site 644651009022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651009023 hypothetical protein; Provisional; Region: PRK04860 644651009024 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 644651009025 DNA-specific endonuclease I; Provisional; Region: PRK15137 644651009026 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 644651009027 RNA methyltransferase, RsmE family; Region: TIGR00046 644651009028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 644651009029 glutathione synthetase; Provisional; Region: PRK05246 644651009030 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 644651009031 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 644651009032 hypothetical protein; Validated; Region: PRK00228 644651009033 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 644651009034 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 644651009035 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 644651009036 catalytic triad [active] 644651009037 potential frameshift: common BLAST hit: gi|385787211|ref|YP_005818320.1| putative cytochrome C biogenesis protein 644651009038 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 644651009039 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 644651009040 DsbD alpha interface [polypeptide binding]; other site 644651009041 catalytic residues [active] 644651009042 RNA polymerase sigma factor; Provisional; Region: PRK12512 644651009043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644651009044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644651009045 DNA binding residues [nucleotide binding] 644651009046 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 644651009047 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644651009048 Walker A motif; other site 644651009049 ATP binding site [chemical binding]; other site 644651009050 Walker B motif; other site 644651009051 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 644651009052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644651009053 catalytic residue [active] 644651009054 YGGT family; Region: YGGT; pfam02325 644651009055 YGGT family; Region: YGGT; pfam02325 644651009056 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 644651009057 active site 644651009058 dimerization interface [polypeptide binding]; other site 644651009059 HemN family oxidoreductase; Provisional; Region: PRK05660 644651009060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644651009061 FeS/SAM binding site; other site 644651009062 HemN C-terminal domain; Region: HemN_C; pfam06969 644651009063 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644651009064 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 644651009065 hypothetical protein; Provisional; Region: PRK10626 644651009066 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 644651009067 hypothetical protein; Provisional; Region: PRK11702 644651009068 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 644651009069 adenine DNA glycosylase; Provisional; Region: PRK10880 644651009070 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644651009071 minor groove reading motif; other site 644651009072 helix-hairpin-helix signature motif; other site 644651009073 substrate binding pocket [chemical binding]; other site 644651009074 active site 644651009075 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 644651009076 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 644651009077 DNA binding and oxoG recognition site [nucleotide binding] 644651009078 oxidative damage protection protein; Provisional; Region: PRK05408 644651009079 murein transglycosylase C; Provisional; Region: mltC; PRK11671 644651009080 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 644651009081 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644651009082 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644651009083 catalytic residue [active] 644651009084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644651009085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644651009086 ornithine decarboxylase; Provisional; Region: PRK13578 644651009087 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 644651009088 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 644651009089 homodimer interface [polypeptide binding]; other site 644651009090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651009091 catalytic residue [active] 644651009092 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 644651009093 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 644651009094 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 644651009095 active site 644651009096 catalytic residues [active] 644651009097 DNA binding site [nucleotide binding] 644651009098 Int/Topo IB signature motif; other site 644651009099 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 644651009100 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 644651009101 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 644651009102 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 644651009103 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 644651009104 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 644651009105 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 644651009106 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 644651009107 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 644651009108 active site 644651009109 Int/Topo IB signature motif; other site 644651009110 catalytic residues [active] 644651009111 DNA binding site [nucleotide binding] 644651009112 DNA cytosine methylase; Provisional; Region: PRK10458 644651009113 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 644651009114 cofactor binding site; other site 644651009115 DNA binding site [nucleotide binding] 644651009116 substrate interaction site [chemical binding]; other site 644651009117 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 644651009118 DNA binding site [nucleotide binding] 644651009119 EcoRII C terminal; Region: EcoRII-C; pfam09019 644651009120 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 644651009121 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 644651009122 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 644651009123 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 644651009124 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 644651009125 metal binding site [ion binding]; metal-binding site 644651009126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651009127 AAA domain; Region: AAA_23; pfam13476 644651009128 Walker A/P-loop; other site 644651009129 ATP binding site [chemical binding]; other site 644651009130 PGAP1-like protein; Region: PGAP1; pfam07819 644651009131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 644651009132 ATP binding site [chemical binding]; other site 644651009133 Mg2+ binding site [ion binding]; other site 644651009134 G-X-G motif; other site 644651009135 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 644651009136 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 644651009137 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 644651009138 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 644651009139 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 644651009140 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 644651009141 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 644651009142 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 644651009143 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 644651009144 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 644651009145 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 644651009146 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 644651009147 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 644651009148 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 644651009149 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644651009150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644651009151 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 644651009152 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 644651009153 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 644651009154 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651009155 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644651009156 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644651009157 active site 644651009158 catalytic tetrad [active] 644651009159 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644651009160 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644651009161 active site 644651009162 catalytic tetrad [active] 644651009163 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 644651009164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644651009165 catalytic site [active] 644651009166 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 644651009167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651009168 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 644651009169 putative substrate translocation pore; other site 644651009170 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 644651009171 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 644651009172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651009173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651009174 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 644651009175 putative effector binding pocket; other site 644651009176 putative dimerization interface [polypeptide binding]; other site 644651009177 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644651009178 short chain dehydrogenase; Provisional; Region: PRK06940 644651009179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651009180 NAD(P) binding site [chemical binding]; other site 644651009181 active site 644651009182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651009183 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644651009184 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644651009185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651009186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651009187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644651009188 dimerization interface [polypeptide binding]; other site 644651009189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651009190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651009191 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 644651009192 Pathogenicity factor; Region: AvrE; pfam11725 644651009193 Pectate lyase; Region: Pectate_lyase; pfam03211 644651009194 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 644651009195 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 644651009196 HrpZ; Region: Hairpins; pfam04877 644651009197 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 644651009198 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651009199 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651009200 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 644651009201 HrpF protein; Region: HrpF; pfam06266 644651009202 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 644651009203 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 644651009204 Type III secretion needle MxiH like; Region: MxiH; cl09641 644651009205 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 644651009206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651009207 Walker A motif; other site 644651009208 ATP binding site [chemical binding]; other site 644651009209 Walker B motif; other site 644651009210 arginine finger; other site 644651009211 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 644651009212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644651009213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651009214 active site 644651009215 phosphorylation site [posttranslational modification] 644651009216 intermolecular recognition site; other site 644651009217 dimerization interface [polypeptide binding]; other site 644651009218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651009219 DNA binding residues [nucleotide binding] 644651009220 dimerization interface [polypeptide binding]; other site 644651009221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651009222 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 644651009223 putative active site [active] 644651009224 heme pocket [chemical binding]; other site 644651009225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651009226 putative active site [active] 644651009227 heme pocket [chemical binding]; other site 644651009228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644651009229 Histidine kinase; Region: HisKA_3; pfam07730 644651009230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651009231 ATP binding site [chemical binding]; other site 644651009232 Mg2+ binding site [ion binding]; other site 644651009233 G-X-G motif; other site 644651009234 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 644651009235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644651009236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644651009237 DNA binding residues [nucleotide binding] 644651009238 HrpJ-like domain; Region: HrpJ; pfam07201 644651009239 TyeA; Region: TyeA; cl07611 644651009240 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 644651009241 FHIPEP family; Region: FHIPEP; pfam00771 644651009242 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 644651009243 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 644651009244 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 644651009245 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644651009246 Walker A motif; other site 644651009247 ATP binding site [chemical binding]; other site 644651009248 Walker B motif; other site 644651009249 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 644651009250 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 644651009251 type III secretion apparatus protein, YscR/HrcR family; Region: yscR; TIGR01102 644651009252 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 644651009253 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 644651009254 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 644651009255 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 644651009256 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 644651009257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644651009258 Coenzyme A binding pocket [chemical binding]; other site 644651009259 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644651009260 active site 644651009261 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 644651009262 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 644651009263 Amidinotransferase; Region: Amidinotransf; cl12043 644651009264 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 644651009265 VirK protein; Region: VirK; pfam06903 644651009266 C-lysozyme inhibitor; Provisional; Region: PRK09993 644651009267 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644651009268 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 644651009269 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 644651009270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651009271 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644651009272 dimerization interface [polypeptide binding]; other site 644651009273 Carbon starvation protein CstA; Region: CstA; pfam02554 644651009274 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 644651009275 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 644651009276 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 644651009277 aromatic amino acid exporter; Provisional; Region: PRK11689 644651009278 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 644651009279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644651009280 dimerization interface [polypeptide binding]; other site 644651009281 putative Zn2+ binding site [ion binding]; other site 644651009282 putative DNA binding site [nucleotide binding]; other site 644651009283 AsnC family; Region: AsnC_trans_reg; pfam01037 644651009284 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 644651009285 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 644651009286 dimerization interface (closed form) [polypeptide binding]; other site 644651009287 ligand binding site [chemical binding]; other site 644651009288 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 644651009289 active site 644651009290 P-loop; other site 644651009291 phosphorylation site [posttranslational modification] 644651009292 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644651009293 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644651009294 methionine cluster; other site 644651009295 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 644651009296 active site 644651009297 phosphorylation site [posttranslational modification] 644651009298 metal binding site [ion binding]; metal-binding site 644651009299 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644651009300 beta-galactosidase; Region: BGL; TIGR03356 644651009301 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 644651009302 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 644651009303 Phytochelatin synthase; Region: Phytochelatin; pfam05023 644651009304 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 644651009305 Ferritin-like domain; Region: Ferritin; pfam00210 644651009306 ferroxidase diiron center [ion binding]; other site 644651009307 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 644651009308 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 644651009309 putative ligand binding residues [chemical binding]; other site 644651009310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644651009311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651009312 DNA binding site [nucleotide binding] 644651009313 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 644651009314 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 644651009315 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 644651009316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644651009317 DNA-binding site [nucleotide binding]; DNA binding site 644651009318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651009319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651009320 homodimer interface [polypeptide binding]; other site 644651009321 catalytic residue [active] 644651009322 Spore Coat Protein U domain; Region: SCPU; cl02253 644651009323 Spore Coat Protein U domain; Region: SCPU; pfam05229 644651009324 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 644651009325 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 644651009326 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 644651009327 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 644651009328 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 644651009329 PapC C-terminal domain; Region: PapC_C; pfam13953 644651009330 Spore Coat Protein U domain; Region: SCPU; pfam05229 644651009331 Spore Coat Protein U domain; Region: SCPU; pfam05229 644651009332 oxidoreductase; Provisional; Region: PRK07985 644651009333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644651009334 NAD(P) binding site [chemical binding]; other site 644651009335 active site 644651009336 citrate-proton symporter; Provisional; Region: PRK15075 644651009337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651009338 putative substrate translocation pore; other site 644651009339 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 644651009340 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 644651009341 biopolymer transport protein ExbB; Provisional; Region: PRK10414 644651009342 cystathionine beta-lyase; Provisional; Region: PRK08114 644651009343 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644651009344 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644651009345 catalytic residue [active] 644651009346 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 644651009347 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644651009348 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 644651009349 PAAR motif; Region: PAAR_motif; pfam05488 644651009350 RHS Repeat; Region: RHS_repeat; pfam05593 644651009351 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 644651009352 RHS Repeat; Region: RHS_repeat; pfam05593 644651009353 RHS Repeat; Region: RHS_repeat; pfam05593 644651009354 RHS Repeat; Region: RHS_repeat; cl11982 644651009355 RHS Repeat; Region: RHS_repeat; pfam05593 644651009356 RHS protein; Region: RHS; pfam03527 644651009357 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651009358 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 644651009359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651009360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651009361 non-specific DNA binding site [nucleotide binding]; other site 644651009362 salt bridge; other site 644651009363 sequence-specific DNA binding site [nucleotide binding]; other site 644651009364 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651009365 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651009366 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 644651009367 active site 644651009368 metal binding site [ion binding]; metal-binding site 644651009369 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651009370 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651009371 active site 644651009372 DNA binding site [nucleotide binding] 644651009373 Int/Topo IB signature motif; other site 644651009374 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651009375 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651009376 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 644651009377 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651009378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651009379 non-specific DNA binding site [nucleotide binding]; other site 644651009380 salt bridge; other site 644651009381 sequence-specific DNA binding site [nucleotide binding]; other site 644651009382 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651009383 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651009384 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 644651009385 active site 644651009386 metal binding site [ion binding]; metal-binding site 644651009387 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651009388 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651009389 active site 644651009390 DNA binding site [nucleotide binding] 644651009391 Int/Topo IB signature motif; other site 644651009392 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651009393 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 644651009394 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644651009395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651009396 non-specific DNA binding site [nucleotide binding]; other site 644651009397 salt bridge; other site 644651009398 sequence-specific DNA binding site [nucleotide binding]; other site 644651009399 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651009400 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651009401 Toprim-like; Region: Toprim_2; pfam13155 644651009402 active site 644651009403 metal binding site [ion binding]; metal-binding site 644651009404 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651009405 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651009406 active site 644651009407 DNA binding site [nucleotide binding] 644651009408 Int/Topo IB signature motif; other site 644651009409 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 644651009410 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 644651009411 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 644651009412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651009413 non-specific DNA binding site [nucleotide binding]; other site 644651009414 salt bridge; other site 644651009415 sequence-specific DNA binding site [nucleotide binding]; other site 644651009416 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651009417 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651009418 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 644651009419 active site 644651009420 metal binding site [ion binding]; metal-binding site 644651009421 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651009422 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651009423 active site 644651009424 DNA binding site [nucleotide binding] 644651009425 Int/Topo IB signature motif; other site 644651009426 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 644651009427 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651009428 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651009429 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 644651009430 active site 644651009431 metal binding site [ion binding]; metal-binding site 644651009432 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651009433 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651009434 active site 644651009435 DNA binding site [nucleotide binding] 644651009436 Int/Topo IB signature motif; other site 644651009437 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 644651009438 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 644651009439 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 644651009440 CHC2 zinc finger; Region: zf-CHC2; cl17510 644651009441 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644651009442 Toprim-like; Region: Toprim_2; pfam13155 644651009443 active site 644651009444 metal binding site [ion binding]; metal-binding site 644651009445 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 644651009446 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651009447 active site 644651009448 DNA binding site [nucleotide binding] 644651009449 Int/Topo IB signature motif; other site 644651009450 Homeodomain-like domain; Region: HTH_23; pfam13384 644651009451 Winged helix-turn helix; Region: HTH_29; pfam13551 644651009452 Homeodomain-like domain; Region: HTH_32; pfam13565 644651009453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651009454 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651009455 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 644651009456 cyclase homology domain; Region: CHD; cd07302 644651009457 nucleotidyl binding site; other site 644651009458 metal binding site [ion binding]; metal-binding site 644651009459 dimer interface [polypeptide binding]; other site 644651009460 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 644651009461 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 644651009462 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 644651009463 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 644651009464 MbeD/MobD like; Region: MbeD_MobD; pfam04899 644651009465 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 644651009466 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 644651009467 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 644651009468 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 644651009469 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 644651009470 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 644651009471 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 644651009472 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 644651009473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651009474 MULE transposase domain; Region: MULE; pfam10551 644651009475 potential frameshift: common BLAST hit: gi|385786496|ref|YP_005817605.1| transposase 644651009476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651009477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651009478 MULE transposase domain; Region: MULE; pfam10551 644651009479 potential frameshift: common BLAST hit: gi|259909833|ref|YP_002650189.1| transposase 644651009480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651009481 MULE transposase domain; Region: MULE; pfam10551 644651009482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651009483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 644651009484 Integrase core domain; Region: rve_3; pfam13683 644651009485 Transposase; Region: HTH_Tnp_1; cl17663 644651009486 potential frameshift: common BLAST hit: gi|259910189|ref|YP_002650545.1| transposase/Integrase 644651009487 DDE domain; Region: DDE_Tnp_IS240; pfam13610 644651009488 Integrase core domain; Region: rve; pfam00665 644651009489 Integrase core domain; Region: rve_2; pfam13333 644651009490 Transposase; Region: HTH_Tnp_1; pfam01527 644651009491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651009492 MULE transposase domain; Region: MULE; pfam10551 644651009493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651009494 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 644651009495 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 644651009496 PilS N terminal; Region: PilS; pfam08805 644651009497 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644651009498 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644651009499 Type II/IV secretion system protein; Region: T2SE; pfam00437 644651009500 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644651009501 Walker A motif; other site 644651009502 ATP binding site [chemical binding]; other site 644651009503 Walker B motif; other site 644651009504 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 644651009505 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 644651009506 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 644651009507 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 644651009508 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 644651009509 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 644651009510 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 644651009511 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 644651009512 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 644651009513 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 644651009514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651009515 catalytic residue [active] 644651009516 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 644651009517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644651009518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 644651009519 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 644651009520 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 644651009521 IucA / IucC family; Region: IucA_IucC; pfam04183 644651009522 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 644651009523 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 644651009524 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 644651009525 N-terminal plug; other site 644651009526 ligand-binding site [chemical binding]; other site 644651009527 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 644651009528 glucose-1-dehydrogenase; Provisional; Region: PRK08936 644651009529 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 644651009530 NAD binding site [chemical binding]; other site 644651009531 homodimer interface [polypeptide binding]; other site 644651009532 active site 644651009533 chaperone protein HchA; Provisional; Region: PRK04155 644651009534 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 644651009535 conserved cys residue [active] 644651009536 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 644651009537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 644651009538 trehalase; Provisional; Region: treF; PRK13270 644651009539 Trehalase; Region: Trehalase; cl17346 644651009540 LysE type translocator; Region: LysE; cl00565 644651009541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651009542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651009543 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 644651009544 putative effector binding pocket; other site 644651009545 dimerization interface [polypeptide binding]; other site 644651009546 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 644651009547 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 644651009548 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 644651009549 NAD(P) binding site [chemical binding]; other site 644651009550 active site 644651009551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651009552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651009553 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 644651009554 putative effector binding pocket; other site 644651009555 putative dimerization interface [polypeptide binding]; other site 644651009556 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 644651009557 potential frameshift: common BLAST hit: gi|259910189|ref|YP_002650545.1| transposase/Integrase 644651009558 DDE domain; Region: DDE_Tnp_IS240; pfam13610 644651009559 Integrase core domain; Region: rve; pfam00665 644651009560 Integrase core domain; Region: rve_2; pfam13333 644651009561 Transposase; Region: HTH_Tnp_1; cl17663 644651009562 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 644651009563 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 644651009564 Cytochrome c; Region: Cytochrom_C; cl11414 644651009565 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 644651009566 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 644651009567 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 644651009568 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 644651009569 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 644651009570 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 644651009571 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 644651009572 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 644651009573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651009574 putative active site [active] 644651009575 heme pocket [chemical binding]; other site 644651009576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651009577 putative active site [active] 644651009578 heme pocket [chemical binding]; other site 644651009579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651009580 putative active site [active] 644651009581 heme pocket [chemical binding]; other site 644651009582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644651009583 metal binding site [ion binding]; metal-binding site 644651009584 active site 644651009585 I-site; other site 644651009586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644651009587 microcin B17 transporter; Reviewed; Region: PRK11098 644651009588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644651009589 PAS domain; Region: PAS_9; pfam13426 644651009590 putative active site [active] 644651009591 heme pocket [chemical binding]; other site 644651009592 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 644651009593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651009594 dimer interface [polypeptide binding]; other site 644651009595 putative CheW interface [polypeptide binding]; other site 644651009596 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 644651009597 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 644651009598 acetyl-CoA synthetase; Provisional; Region: PRK00174 644651009599 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 644651009600 active site 644651009601 CoA binding site [chemical binding]; other site 644651009602 acyl-activating enzyme (AAE) consensus motif; other site 644651009603 AMP binding site [chemical binding]; other site 644651009604 acetate binding site [chemical binding]; other site 644651009605 Predicted membrane protein [Function unknown]; Region: COG3162 644651009606 potential frameshift: common BLAST hit: gi|385786222|ref|YP_005817331.1| cation/acetate symporter 644651009607 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 644651009608 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 644651009609 Na binding site [ion binding]; other site 644651009610 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644651009611 LrgB-like family; Region: LrgB; cl00596 644651009612 LrgB-like family; Region: LrgB; cl00596 644651009613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651009614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651009615 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 644651009616 putative dimerization interface [polypeptide binding]; other site 644651009617 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 644651009618 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 644651009619 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 644651009620 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 644651009621 putative C-terminal domain interface [polypeptide binding]; other site 644651009622 putative GSH binding site (G-site) [chemical binding]; other site 644651009623 putative dimer interface [polypeptide binding]; other site 644651009624 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 644651009625 putative N-terminal domain interface [polypeptide binding]; other site 644651009626 putative dimer interface [polypeptide binding]; other site 644651009627 putative substrate binding pocket (H-site) [chemical binding]; other site 644651009628 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 644651009629 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 644651009630 DNA binding residues [nucleotide binding] 644651009631 dimer interface [polypeptide binding]; other site 644651009632 [2Fe-2S] cluster binding site [ion binding]; other site 644651009633 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 644651009634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651009635 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644651009636 DNA-binding interface [nucleotide binding]; DNA binding site 644651009637 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 644651009638 haemagglutination activity domain; Region: Haemagg_act; pfam05860 644651009639 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 644651009640 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 644651009641 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 644651009642 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 644651009643 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 644651009644 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 644651009645 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 644651009646 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644651009647 dimer interface [polypeptide binding]; other site 644651009648 ssDNA binding site [nucleotide binding]; other site 644651009649 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644651009650 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 644651009651 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 644651009652 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 644651009653 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 644651009654 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 644651009655 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 644651009656 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 644651009657 putative NAD(P) binding site [chemical binding]; other site 644651009658 putative substrate binding site [chemical binding]; other site 644651009659 catalytic Zn binding site [ion binding]; other site 644651009660 structural Zn binding site [ion binding]; other site 644651009661 dimer interface [polypeptide binding]; other site 644651009662 LysM domain; Region: LysM; pfam01476 644651009663 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 644651009664 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 644651009665 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 644651009666 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 644651009667 Protein of unknown function (DUF419); Region: DUF419; cl15265 644651009668 Uncharacterized conserved protein [Function unknown]; Region: COG0432 644651009669 LysM domain; Region: LysM; pfam01476 644651009670 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 644651009671 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 644651009672 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 644651009673 Protein of unknown function (DUF419); Region: DUF419; cl15265 644651009674 LysM domain; Region: LysM; pfam01476 644651009675 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 644651009676 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 644651009677 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 644651009678 Protein of unknown function (DUF419); Region: DUF419; cl15265 644651009679 Uncharacterized conserved protein [Function unknown]; Region: COG0432 644651009680 LysM domain; Region: LysM; pfam01476 644651009681 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 644651009682 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 644651009683 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 644651009684 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 644651009685 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 644651009686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651009687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651009688 homodimer interface [polypeptide binding]; other site 644651009689 catalytic residue [active] 644651009690 Uncharacterized conserved protein [Function unknown]; Region: COG1284 644651009691 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 644651009692 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 644651009693 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 644651009694 replicative DNA helicase; Provisional; Region: PRK08006 644651009695 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 644651009696 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 644651009697 Walker A motif; other site 644651009698 ATP binding site [chemical binding]; other site 644651009699 Walker B motif; other site 644651009700 DNA binding loops [nucleotide binding] 644651009701 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 644651009702 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 644651009703 NADP binding site [chemical binding]; other site 644651009704 dimer interface [polypeptide binding]; other site 644651009705 phage shock protein G; Reviewed; Region: pspG; PRK09459 644651009706 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 644651009707 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 644651009708 FMN binding site [chemical binding]; other site 644651009709 active site 644651009710 catalytic residues [active] 644651009711 substrate binding site [chemical binding]; other site 644651009712 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 644651009713 ferric uptake regulator; Provisional; Region: fur; PRK09462 644651009714 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644651009715 metal binding site 2 [ion binding]; metal-binding site 644651009716 putative DNA binding helix; other site 644651009717 metal binding site 1 [ion binding]; metal-binding site 644651009718 dimer interface [polypeptide binding]; other site 644651009719 structural Zn2+ binding site [ion binding]; other site 644651009720 hypothetical protein; Provisional; Region: PRK10428 644651009721 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 644651009722 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 644651009723 LexA repressor; Validated; Region: PRK00215 644651009724 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 644651009725 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 644651009726 Catalytic site [active] 644651009727 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 644651009728 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 644651009729 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 644651009730 putative acyl-acceptor binding pocket; other site 644651009731 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 644651009732 UbiA prenyltransferase family; Region: UbiA; pfam01040 644651009733 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 644651009734 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 644651009735 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 644651009736 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 644651009737 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 644651009738 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 644651009739 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 644651009740 active site 644651009741 dimer interface [polypeptide binding]; other site 644651009742 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 644651009743 dimer interface [polypeptide binding]; other site 644651009744 active site 644651009745 aspartate kinase III; Validated; Region: PRK09084 644651009746 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 644651009747 nucleotide binding site [chemical binding]; other site 644651009748 substrate binding site [chemical binding]; other site 644651009749 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 644651009750 lysine allosteric regulatory site; other site 644651009751 dimer interface [polypeptide binding]; other site 644651009752 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 644651009753 dimer interface [polypeptide binding]; other site 644651009754 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 644651009755 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 644651009756 PhoU domain; Region: PhoU; pfam01895 644651009757 homoserine O-succinyltransferase; Provisional; Region: PRK05368 644651009758 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 644651009759 proposed active site lysine [active] 644651009760 conserved cys residue [active] 644651009761 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 644651009762 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 644651009763 trimer interface [polypeptide binding]; other site 644651009764 putative metal binding site [ion binding]; other site 644651009765 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 644651009766 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 644651009767 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 644651009768 shikimate binding site; other site 644651009769 NAD(P) binding site [chemical binding]; other site 644651009770 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 644651009771 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644651009772 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 644651009773 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644651009774 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644651009775 hypothetical protein; Validated; Region: PRK03430 644651009776 hypothetical protein; Provisional; Region: PRK10736 644651009777 DNA protecting protein DprA; Region: dprA; TIGR00732 644651009778 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 644651009779 active site 644651009780 catalytic residues [active] 644651009781 metal binding site [ion binding]; metal-binding site 644651009782 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 644651009783 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 644651009784 putative active site [active] 644651009785 substrate binding site [chemical binding]; other site 644651009786 putative cosubstrate binding site; other site 644651009787 catalytic site [active] 644651009788 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 644651009789 substrate binding site [chemical binding]; other site 644651009790 16S rRNA methyltransferase B; Provisional; Region: PRK10901 644651009791 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 644651009792 putative RNA binding site [nucleotide binding]; other site 644651009793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651009794 S-adenosylmethionine binding site [chemical binding]; other site 644651009795 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 644651009796 TrkA-N domain; Region: TrkA_N; pfam02254 644651009797 TrkA-C domain; Region: TrkA_C; pfam02080 644651009798 TrkA-N domain; Region: TrkA_N; pfam02254 644651009799 TrkA-C domain; Region: TrkA_C; pfam02080 644651009800 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 644651009801 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 644651009802 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 644651009803 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 644651009804 DNA binding residues [nucleotide binding] 644651009805 dimer interface [polypeptide binding]; other site 644651009806 metal binding site [ion binding]; metal-binding site 644651009807 hypothetical protein; Provisional; Region: PRK10203 644651009808 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 644651009809 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 644651009810 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 644651009811 alphaNTD homodimer interface [polypeptide binding]; other site 644651009812 alphaNTD - beta interaction site [polypeptide binding]; other site 644651009813 alphaNTD - beta' interaction site [polypeptide binding]; other site 644651009814 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 644651009815 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 644651009816 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 644651009817 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651009818 RNA binding surface [nucleotide binding]; other site 644651009819 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 644651009820 30S ribosomal protein S13; Region: bact_S13; TIGR03631 644651009821 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 644651009822 SecY translocase; Region: SecY; pfam00344 644651009823 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 644651009824 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 644651009825 23S rRNA binding site [nucleotide binding]; other site 644651009826 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 644651009827 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 644651009828 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 644651009829 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 644651009830 23S rRNA interface [nucleotide binding]; other site 644651009831 5S rRNA interface [nucleotide binding]; other site 644651009832 L27 interface [polypeptide binding]; other site 644651009833 L5 interface [polypeptide binding]; other site 644651009834 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 644651009835 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644651009836 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644651009837 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 644651009838 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 644651009839 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 644651009840 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 644651009841 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 644651009842 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 644651009843 RNA binding site [nucleotide binding]; other site 644651009844 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 644651009845 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 644651009846 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 644651009847 23S rRNA interface [nucleotide binding]; other site 644651009848 putative translocon interaction site; other site 644651009849 signal recognition particle (SRP54) interaction site; other site 644651009850 L23 interface [polypeptide binding]; other site 644651009851 trigger factor interaction site; other site 644651009852 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 644651009853 23S rRNA interface [nucleotide binding]; other site 644651009854 5S rRNA interface [nucleotide binding]; other site 644651009855 putative antibiotic binding site [chemical binding]; other site 644651009856 L25 interface [polypeptide binding]; other site 644651009857 L27 interface [polypeptide binding]; other site 644651009858 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 644651009859 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 644651009860 G-X-X-G motif; other site 644651009861 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 644651009862 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 644651009863 protein-rRNA interface [nucleotide binding]; other site 644651009864 putative translocon binding site; other site 644651009865 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 644651009866 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 644651009867 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 644651009868 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 644651009869 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 644651009870 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 644651009871 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 644651009872 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 644651009873 elongation factor Tu; Reviewed; Region: PRK00049 644651009874 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 644651009875 G1 box; other site 644651009876 GEF interaction site [polypeptide binding]; other site 644651009877 GTP/Mg2+ binding site [chemical binding]; other site 644651009878 Switch I region; other site 644651009879 G2 box; other site 644651009880 G3 box; other site 644651009881 Switch II region; other site 644651009882 G4 box; other site 644651009883 G5 box; other site 644651009884 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 644651009885 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 644651009886 Antibiotic Binding Site [chemical binding]; other site 644651009887 elongation factor G; Reviewed; Region: PRK00007 644651009888 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 644651009889 G1 box; other site 644651009890 putative GEF interaction site [polypeptide binding]; other site 644651009891 GTP/Mg2+ binding site [chemical binding]; other site 644651009892 Switch I region; other site 644651009893 G2 box; other site 644651009894 G3 box; other site 644651009895 Switch II region; other site 644651009896 G4 box; other site 644651009897 G5 box; other site 644651009898 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 644651009899 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 644651009900 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 644651009901 30S ribosomal protein S7; Validated; Region: PRK05302 644651009902 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 644651009903 sulfur relay protein TusC; Validated; Region: PRK00211 644651009904 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 644651009905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 644651009906 YheO-like PAS domain; Region: PAS_6; pfam08348 644651009907 HTH domain; Region: HTH_22; pfam13309 644651009908 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 644651009909 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 644651009910 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644651009911 phi X174 lysis protein; Provisional; Region: PRK02793 644651009912 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 644651009913 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644651009914 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 644651009915 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 644651009916 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 644651009917 TrkA-N domain; Region: TrkA_N; pfam02254 644651009918 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 644651009919 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 644651009920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651009921 Walker A/P-loop; other site 644651009922 ATP binding site [chemical binding]; other site 644651009923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651009924 ABC transporter signature motif; other site 644651009925 Walker B; other site 644651009926 D-loop; other site 644651009927 ABC transporter; Region: ABC_tran_2; pfam12848 644651009928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644651009929 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 644651009930 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 644651009931 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 644651009932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651009933 dimer interface [polypeptide binding]; other site 644651009934 conserved gate region; other site 644651009935 putative PBP binding loops; other site 644651009936 ABC-ATPase subunit interface; other site 644651009937 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 644651009938 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 644651009939 Walker A/P-loop; other site 644651009940 ATP binding site [chemical binding]; other site 644651009941 Q-loop/lid; other site 644651009942 ABC transporter signature motif; other site 644651009943 Walker B; other site 644651009944 D-loop; other site 644651009945 H-loop/switch region; other site 644651009946 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 644651009947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651009948 substrate binding pocket [chemical binding]; other site 644651009949 membrane-bound complex binding site; other site 644651009950 hinge residues; other site 644651009951 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 644651009952 putative hydrolase; Provisional; Region: PRK10985 644651009953 hypothetical protein; Provisional; Region: PRK04966 644651009954 phosphoribulokinase; Provisional; Region: PRK15453 644651009955 hypothetical protein; Provisional; Region: PRK10738 644651009956 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 644651009957 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 644651009958 ligand binding site [chemical binding]; other site 644651009959 flexible hinge region; other site 644651009960 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 644651009961 putative switch regulator; other site 644651009962 non-specific DNA interactions [nucleotide binding]; other site 644651009963 DNA binding site [nucleotide binding] 644651009964 sequence specific DNA binding site [nucleotide binding]; other site 644651009965 putative cAMP binding site [chemical binding]; other site 644651009966 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 644651009967 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 644651009968 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 644651009969 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 644651009970 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644651009971 inhibitor-cofactor binding pocket; inhibition site 644651009972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651009973 catalytic residue [active] 644651009974 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 644651009975 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 644651009976 glutamine binding [chemical binding]; other site 644651009977 catalytic triad [active] 644651009978 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 644651009979 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 644651009980 substrate binding site [chemical binding]; other site 644651009981 putative transporter; Provisional; Region: PRK03699 644651009982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651009983 putative substrate translocation pore; other site 644651009984 cytosine deaminase; Provisional; Region: PRK09230 644651009985 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 644651009986 active site 644651009987 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 644651009988 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 644651009989 active site 644651009990 HIGH motif; other site 644651009991 dimer interface [polypeptide binding]; other site 644651009992 KMSKS motif; other site 644651009993 phosphoglycolate phosphatase; Provisional; Region: PRK13222 644651009994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651009995 motif II; other site 644651009996 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 644651009997 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 644651009998 substrate binding site [chemical binding]; other site 644651009999 hexamer interface [polypeptide binding]; other site 644651010000 metal binding site [ion binding]; metal-binding site 644651010001 DNA adenine methylase; Provisional; Region: PRK10904 644651010002 hypothetical protein; Reviewed; Region: PRK11901 644651010003 cell division protein DamX; Validated; Region: PRK10905 644651010004 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 644651010005 active site 644651010006 dimer interface [polypeptide binding]; other site 644651010007 metal binding site [ion binding]; metal-binding site 644651010008 shikimate kinase; Reviewed; Region: aroK; PRK00131 644651010009 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 644651010010 ADP binding site [chemical binding]; other site 644651010011 magnesium binding site [ion binding]; other site 644651010012 putative shikimate binding site; other site 644651010013 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 644651010014 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 644651010015 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 644651010016 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 644651010017 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 644651010018 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 644651010019 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 644651010020 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 644651010021 Transglycosylase; Region: Transgly; pfam00912 644651010022 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 644651010023 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 644651010024 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 644651010025 ADP-ribose binding site [chemical binding]; other site 644651010026 dimer interface [polypeptide binding]; other site 644651010027 active site 644651010028 nudix motif; other site 644651010029 metal binding site [ion binding]; metal-binding site 644651010030 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 644651010031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644651010032 RNA binding surface [nucleotide binding]; other site 644651010033 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 644651010034 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 644651010035 dimerization interface [polypeptide binding]; other site 644651010036 domain crossover interface; other site 644651010037 redox-dependent activation switch; other site 644651010038 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 644651010039 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 644651010040 active site 644651010041 substrate-binding site [chemical binding]; other site 644651010042 metal-binding site [ion binding] 644651010043 ATP binding site [chemical binding]; other site 644651010044 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 644651010045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644651010046 dimerization interface [polypeptide binding]; other site 644651010047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651010048 dimer interface [polypeptide binding]; other site 644651010049 phosphorylation site [posttranslational modification] 644651010050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651010051 ATP binding site [chemical binding]; other site 644651010052 Mg2+ binding site [ion binding]; other site 644651010053 G-X-G motif; other site 644651010054 osmolarity response regulator; Provisional; Region: ompR; PRK09468 644651010055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644651010056 active site 644651010057 phosphorylation site [posttranslational modification] 644651010058 intermolecular recognition site; other site 644651010059 dimerization interface [polypeptide binding]; other site 644651010060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644651010061 DNA binding site [nucleotide binding] 644651010062 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 644651010063 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 644651010064 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 644651010065 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 644651010066 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 644651010067 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 644651010068 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 644651010069 RNA binding site [nucleotide binding]; other site 644651010070 Winged helix-turn helix; Region: HTH_29; pfam13551 644651010071 Homeodomain-like domain; Region: HTH_23; pfam13384 644651010072 Homeodomain-like domain; Region: HTH_32; pfam13565 644651010073 carboxylesterase BioH; Provisional; Region: PRK10349 644651010074 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 644651010075 DNA utilization protein GntX; Provisional; Region: PRK11595 644651010076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644651010077 active site 644651010078 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 644651010079 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 644651010080 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 644651010081 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 644651010082 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 644651010083 maltodextrin phosphorylase; Provisional; Region: PRK14985 644651010084 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 644651010085 active site pocket [active] 644651010086 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 644651010087 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 644651010088 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644651010089 intramembrane serine protease GlpG; Provisional; Region: PRK10907 644651010090 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 644651010091 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 644651010092 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 644651010093 active site residue [active] 644651010094 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 644651010095 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644651010096 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644651010097 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644651010098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644651010099 glycogen synthase; Provisional; Region: glgA; PRK00654 644651010100 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 644651010101 ADP-binding pocket [chemical binding]; other site 644651010102 homodimer interface [polypeptide binding]; other site 644651010103 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 644651010104 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 644651010105 ligand binding site; other site 644651010106 oligomer interface; other site 644651010107 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 644651010108 dimer interface [polypeptide binding]; other site 644651010109 N-terminal domain interface [polypeptide binding]; other site 644651010110 sulfate 1 binding site; other site 644651010111 glycogen debranching enzyme; Provisional; Region: PRK03705 644651010112 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 644651010113 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 644651010114 active site 644651010115 catalytic site [active] 644651010116 glycogen branching enzyme; Provisional; Region: PRK05402 644651010117 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 644651010118 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 644651010119 active site 644651010120 catalytic site [active] 644651010121 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 644651010122 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 644651010123 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 644651010124 low affinity gluconate transporter; Provisional; Region: PRK10472 644651010125 gluconate transporter; Region: gntP; TIGR00791 644651010126 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 644651010127 ATP-binding site [chemical binding]; other site 644651010128 Gluconate-6-phosphate binding site [chemical binding]; other site 644651010129 Shikimate kinase; Region: SKI; pfam01202 644651010130 potential protein location (hypothetical protein) that overlaps protein (gntK) 644651010131 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 644651010132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651010133 DNA binding site [nucleotide binding] 644651010134 domain linker motif; other site 644651010135 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 644651010136 putative ligand binding site [chemical binding]; other site 644651010137 putative dimerization interface [polypeptide binding]; other site 644651010138 Pirin-related protein [General function prediction only]; Region: COG1741 644651010139 Pirin; Region: Pirin; pfam02678 644651010140 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644651010141 Coenzyme A binding pocket [chemical binding]; other site 644651010142 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 644651010143 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 644651010144 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 644651010145 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 644651010146 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 644651010147 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 644651010148 putative active site [active] 644651010149 catalytic site [active] 644651010150 putative metal binding site [ion binding]; other site 644651010151 TOBE domain; Region: TOBE_2; pfam08402 644651010152 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644651010153 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 644651010154 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 644651010155 Walker A/P-loop; other site 644651010156 ATP binding site [chemical binding]; other site 644651010157 Q-loop/lid; other site 644651010158 ABC transporter signature motif; other site 644651010159 Walker B; other site 644651010160 D-loop; other site 644651010161 H-loop/switch region; other site 644651010162 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 644651010163 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 644651010164 Walker A/P-loop; other site 644651010165 ATP binding site [chemical binding]; other site 644651010166 Q-loop/lid; other site 644651010167 ABC transporter signature motif; other site 644651010168 Walker B; other site 644651010169 D-loop; other site 644651010170 H-loop/switch region; other site 644651010171 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 644651010172 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 644651010173 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644651010174 TM-ABC transporter signature motif; other site 644651010175 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644651010176 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644651010177 TM-ABC transporter signature motif; other site 644651010178 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 644651010179 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 644651010180 dimerization interface [polypeptide binding]; other site 644651010181 ligand binding site [chemical binding]; other site 644651010182 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 644651010183 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 644651010184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644651010185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644651010186 DNA binding residues [nucleotide binding] 644651010187 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 644651010188 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 644651010189 cell division protein FtsE; Provisional; Region: PRK10908 644651010190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651010191 Walker A/P-loop; other site 644651010192 ATP binding site [chemical binding]; other site 644651010193 Q-loop/lid; other site 644651010194 ABC transporter signature motif; other site 644651010195 Walker B; other site 644651010196 D-loop; other site 644651010197 H-loop/switch region; other site 644651010198 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 644651010199 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 644651010200 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 644651010201 P loop; other site 644651010202 GTP binding site [chemical binding]; other site 644651010203 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 644651010204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651010205 S-adenosylmethionine binding site [chemical binding]; other site 644651010206 hypothetical protein; Provisional; Region: PRK10910 644651010207 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 644651010208 Predicted membrane protein [Function unknown]; Region: COG3714 644651010209 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 644651010210 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644651010211 metal-binding site [ion binding] 644651010212 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644651010213 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 644651010214 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 644651010215 CPxP motif; other site 644651010216 hypothetical protein; Provisional; Region: PRK11212 644651010217 hypothetical protein; Provisional; Region: PRK11615 644651010218 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 644651010219 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 644651010220 Metal-binding active site; metal-binding site 644651010221 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 644651010222 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644651010223 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644651010224 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 644651010225 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 644651010226 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644651010227 PYR/PP interface [polypeptide binding]; other site 644651010228 dimer interface [polypeptide binding]; other site 644651010229 TPP binding site [chemical binding]; other site 644651010230 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644651010231 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 644651010232 TPP-binding site; other site 644651010233 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644651010234 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 644651010235 substrate binding site [chemical binding]; other site 644651010236 ATP binding site [chemical binding]; other site 644651010237 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 644651010238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 644651010239 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644651010240 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644651010241 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644651010242 putative active site [active] 644651010243 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 644651010244 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 644651010245 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 644651010246 tetrameric interface [polypeptide binding]; other site 644651010247 NAD binding site [chemical binding]; other site 644651010248 catalytic residues [active] 644651010249 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 644651010250 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644651010251 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 644651010252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644651010253 proline/glycine betaine transporter; Provisional; Region: PRK10642 644651010254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651010255 putative substrate translocation pore; other site 644651010256 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 644651010257 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 644651010258 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 644651010259 putative NAD(P) binding site [chemical binding]; other site 644651010260 putative substrate binding site [chemical binding]; other site 644651010261 catalytic Zn binding site [ion binding]; other site 644651010262 structural Zn binding site [ion binding]; other site 644651010263 dimer interface [polypeptide binding]; other site 644651010264 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 644651010265 DNA binding residues [nucleotide binding] 644651010266 dimerization interface [polypeptide binding]; other site 644651010267 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 644651010268 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 644651010269 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 644651010270 homotrimer interaction site [polypeptide binding]; other site 644651010271 putative active site [active] 644651010272 ornithine cyclodeaminase; Validated; Region: PRK06199 644651010273 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 644651010274 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644651010275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644651010276 Amino acid permease; Region: AA_permease; pfam00324 644651010277 Predicted flavoproteins [General function prediction only]; Region: COG2081 644651010278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644651010279 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 644651010280 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 644651010281 universal stress protein UspB; Provisional; Region: PRK04960 644651010282 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644651010283 Ligand Binding Site [chemical binding]; other site 644651010284 putative methyltransferase; Provisional; Region: PRK10742 644651010285 oligopeptidase A; Provisional; Region: PRK10911 644651010286 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 644651010287 active site 644651010288 Zn binding site [ion binding]; other site 644651010289 CAAX protease self-immunity; Region: Abi; pfam02517 644651010290 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 644651010291 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644651010292 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 644651010293 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 644651010294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644651010295 ATP binding site [chemical binding]; other site 644651010296 putative Mg++ binding site [ion binding]; other site 644651010297 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 644651010298 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 644651010299 Homeodomain-like domain; Region: HTH_23; pfam13384 644651010300 Winged helix-turn helix; Region: HTH_29; pfam13551 644651010301 Homeodomain-like domain; Region: HTH_32; pfam13565 644651010302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 644651010303 DDE superfamily endonuclease; Region: DDE_3; pfam13358 644651010304 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 644651010305 HsdM N-terminal domain; Region: HsdM_N; pfam12161 644651010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644651010307 S-adenosylmethionine binding site [chemical binding]; other site 644651010308 glutathione reductase; Validated; Region: PRK06116 644651010309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644651010310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644651010311 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644651010312 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 644651010313 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 644651010314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644651010315 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 644651010316 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 644651010317 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 644651010318 RelB antitoxin; Region: RelB; cl01171 644651010319 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644651010320 active site 644651010321 Int/Topo IB signature motif; other site 644651010322 DNA binding site [nucleotide binding] 644651010323 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 644651010324 haemagglutination activity domain; Region: Haemagg_act; pfam05860 644651010325 potential frameshift: common BLAST hit: gi|385786488|ref|YP_005817597.1| ShlB 644651010326 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 644651010327 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 644651010328 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 644651010329 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 644651010330 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 644651010331 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 644651010332 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 644651010333 FMN-binding pocket [chemical binding]; other site 644651010334 flavin binding motif; other site 644651010335 phosphate binding motif [ion binding]; other site 644651010336 beta-alpha-beta structure motif; other site 644651010337 NAD binding pocket [chemical binding]; other site 644651010338 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644651010339 catalytic loop [active] 644651010340 iron binding site [ion binding]; other site 644651010341 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 644651010342 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 644651010343 [2Fe-2S] cluster binding site [ion binding]; other site 644651010344 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 644651010345 hydrophobic ligand binding site; other site 644651010346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651010347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651010348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644651010349 dimerization interface [polypeptide binding]; other site 644651010350 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644651010351 hypothetical protein; Provisional; Region: PRK05208 644651010352 HlyD family secretion protein; Region: HlyD; pfam00529 644651010353 HlyD family secretion protein; Region: HlyD_3; pfam13437 644651010354 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 644651010355 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 644651010356 putative active site [active] 644651010357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644651010358 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 644651010359 Walker A/P-loop; other site 644651010360 ATP binding site [chemical binding]; other site 644651010361 Q-loop/lid; other site 644651010362 ABC transporter signature motif; other site 644651010363 Walker B; other site 644651010364 D-loop; other site 644651010365 H-loop/switch region; other site 644651010366 Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988 644651010367 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 644651010368 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 644651010369 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 644651010370 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 644651010371 FAD binding pocket [chemical binding]; other site 644651010372 FAD binding motif [chemical binding]; other site 644651010373 phosphate binding motif [ion binding]; other site 644651010374 NAD binding pocket [chemical binding]; other site 644651010375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 644651010376 Protein of unknown function, DUF482; Region: DUF482; pfam04339 644651010377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644651010378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651010379 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644651010380 Walker A/P-loop; other site 644651010381 ATP binding site [chemical binding]; other site 644651010382 Q-loop/lid; other site 644651010383 ABC transporter signature motif; other site 644651010384 Walker B; other site 644651010385 D-loop; other site 644651010386 H-loop/switch region; other site 644651010387 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 644651010388 active site 644651010389 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 644651010390 Strictosidine synthase; Region: Str_synth; pfam03088 644651010391 potential frameshift: common BLAST hit: gi|259910189|ref|YP_002650545.1| transposase/Integrase 644651010392 DDE domain; Region: DDE_Tnp_IS240; pfam13610 644651010393 Integrase core domain; Region: rve; pfam00665 644651010394 Integrase core domain; Region: rve_2; pfam13333 644651010395 Transposase; Region: HTH_Tnp_1; cl17663 644651010396 sensor protein KdpD; Provisional; Region: PRK10490 644651010397 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 644651010398 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 644651010399 Ligand Binding Site [chemical binding]; other site 644651010400 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 644651010401 GAF domain; Region: GAF_3; pfam13492 644651010402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644651010403 dimer interface [polypeptide binding]; other site 644651010404 phosphorylation site [posttranslational modification] 644651010405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651010406 ATP binding site [chemical binding]; other site 644651010407 Mg2+ binding site [ion binding]; other site 644651010408 G-X-G motif; other site 644651010409 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 644651010410 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 644651010411 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644651010412 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 644651010413 potassium-transporting ATPase subunit F; Provisional; Region: kdpF; PRK14748 644651010414 potassium-transporting ATPase subunit F; Provisional; Region: kdpF; PRK14748 644651010415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651010416 MULE transposase domain; Region: MULE; pfam10551 644651010417 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 644651010418 active site 644651010419 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 644651010420 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644651010421 Domain of unknown function DUF; Region: DUF204; pfam02659 644651010422 Domain of unknown function DUF; Region: DUF204; pfam02659 644651010423 hypothetical protein; Provisional; Region: PRK07338 644651010424 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 644651010425 metal binding site [ion binding]; metal-binding site 644651010426 dimer interface [polypeptide binding]; other site 644651010427 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 644651010428 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 644651010429 MgtC family; Region: MgtC; pfam02308 644651010430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651010431 metabolite-proton symporter; Region: 2A0106; TIGR00883 644651010432 putative substrate translocation pore; other site 644651010433 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 644651010434 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 644651010435 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 644651010436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644651010437 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 644651010438 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644651010439 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 644651010440 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 644651010441 putative diguanylate cyclase; Provisional; Region: PRK13561 644651010442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644651010443 metal binding site [ion binding]; metal-binding site 644651010444 active site 644651010445 I-site; other site 644651010446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644651010447 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 644651010448 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 644651010449 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 644651010450 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 644651010451 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 644651010452 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 644651010453 cellulose synthase regulator protein; Provisional; Region: PRK11114 644651010454 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 644651010455 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 644651010456 DXD motif; other site 644651010457 PilZ domain; Region: PilZ; pfam07238 644651010458 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 644651010459 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644651010460 P-loop; other site 644651010461 Magnesium ion binding site [ion binding]; other site 644651010462 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 644651010463 potential frameshift: common BLAST hit: gi|385786541|ref|YP_005817650.1| dipeptide transporter ATP-binding subunit 644651010464 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651010465 ABC transporter signature motif; other site 644651010466 Walker B; other site 644651010467 D-loop; other site 644651010468 H-loop/switch region; other site 644651010469 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 644651010470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651010471 Walker A/P-loop; other site 644651010472 ATP binding site [chemical binding]; other site 644651010473 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 644651010474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644651010475 Walker A/P-loop; other site 644651010476 ATP binding site [chemical binding]; other site 644651010477 Q-loop/lid; other site 644651010478 ABC transporter signature motif; other site 644651010479 Walker B; other site 644651010480 D-loop; other site 644651010481 H-loop/switch region; other site 644651010482 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 644651010483 dipeptide transporter; Provisional; Region: PRK10913 644651010484 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644651010485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651010486 dimer interface [polypeptide binding]; other site 644651010487 conserved gate region; other site 644651010488 putative PBP binding loops; other site 644651010489 ABC-ATPase subunit interface; other site 644651010490 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644651010491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651010492 dimer interface [polypeptide binding]; other site 644651010493 conserved gate region; other site 644651010494 putative PBP binding loops; other site 644651010495 ABC-ATPase subunit interface; other site 644651010496 potential frameshift: common BLAST hit: gi|385786545|ref|YP_005817654.1| dipeptide ABC transporter substrate-binding protein 644651010497 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644651010498 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 644651010499 peptide binding site [polypeptide binding]; other site 644651010500 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644651010501 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 644651010502 phosphoethanolamine transferase; Provisional; Region: PRK11560 644651010503 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 644651010504 Sulfatase; Region: Sulfatase; pfam00884 644651010505 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 644651010506 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644651010507 MarR family; Region: MarR; pfam01047 644651010508 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 644651010509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644651010510 Zn2+ binding site [ion binding]; other site 644651010511 Mg2+ binding site [ion binding]; other site 644651010512 Predicted amidohydrolase [General function prediction only]; Region: COG0388 644651010513 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 644651010514 active site 644651010515 catalytic triad [active] 644651010516 dimer interface [polypeptide binding]; other site 644651010517 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 644651010518 potential frameshift: common BLAST hit: gi|385786496|ref|YP_005817605.1| transposase 644651010519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651010520 MULE transposase domain; Region: MULE; pfam10551 644651010521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651010522 HNH endonuclease; Region: HNH_2; pfam13391 644651010523 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 644651010524 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 644651010525 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 644651010526 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644651010527 potential frameshift: common BLAST hit: gi|188535516|ref|YP_001909313.1| isochorismatase hydrolase 644651010528 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 644651010529 conserved cis-peptide bond; other site 644651010530 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 644651010531 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 644651010532 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 644651010533 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 644651010534 Uncharacterized conserved protein [Function unknown]; Region: COG4095 644651010535 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 644651010536 Acyltransferase family; Region: Acyl_transf_3; pfam01757 644651010537 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 644651010538 dimer interface [polypeptide binding]; other site 644651010539 motif 1; other site 644651010540 active site 644651010541 motif 2; other site 644651010542 motif 3; other site 644651010543 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 644651010544 DALR anticodon binding domain; Region: DALR_1; pfam05746 644651010545 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644651010546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651010547 non-specific DNA binding site [nucleotide binding]; other site 644651010548 salt bridge; other site 644651010549 sequence-specific DNA binding site [nucleotide binding]; other site 644651010550 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 644651010551 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 644651010552 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 644651010553 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 644651010554 active site 644651010555 P-loop; other site 644651010556 phosphorylation site [posttranslational modification] 644651010557 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644651010558 active site 644651010559 phosphorylation site [posttranslational modification] 644651010560 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 644651010561 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 644651010562 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 644651010563 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 644651010564 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 644651010565 hypothetical protein; Provisional; Region: PRK11020 644651010566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644651010567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644651010568 DNA binding residues [nucleotide binding] 644651010569 dimerization interface [polypeptide binding]; other site 644651010570 FaeA-like protein; Region: FaeA; pfam04703 644651010571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 644651010572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644651010573 DNA binding site [nucleotide binding] 644651010574 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 644651010575 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 644651010576 putative ligand binding site [chemical binding]; other site 644651010577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644651010578 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 644651010579 TM-ABC transporter signature motif; other site 644651010580 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 644651010581 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 644651010582 Walker A/P-loop; other site 644651010583 ATP binding site [chemical binding]; other site 644651010584 Q-loop/lid; other site 644651010585 ABC transporter signature motif; other site 644651010586 Walker B; other site 644651010587 D-loop; other site 644651010588 H-loop/switch region; other site 644651010589 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 644651010590 superoxide dismutase; Provisional; Region: PRK10925 644651010591 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 644651010592 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 644651010593 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 644651010594 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644651010595 inhibitor-cofactor binding pocket; inhibition site 644651010596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651010597 catalytic residue [active] 644651010598 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644651010599 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 644651010600 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644651010601 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 644651010602 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 644651010603 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 644651010604 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644651010605 putative glutathione S-transferase; Provisional; Region: PRK10357 644651010606 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 644651010607 dimer interface [polypeptide binding]; other site 644651010608 N-terminal domain interface [polypeptide binding]; other site 644651010609 putative substrate binding pocket (H-site) [chemical binding]; other site 644651010610 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 644651010611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644651010612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644651010613 DNA binding site [nucleotide binding] 644651010614 domain linker motif; other site 644651010615 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 644651010616 putative dimerization interface [polypeptide binding]; other site 644651010617 putative ligand binding site [chemical binding]; other site 644651010618 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 644651010619 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 644651010620 active site 644651010621 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 644651010622 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644651010623 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 644651010624 substrate binding site [chemical binding]; other site 644651010625 ATP binding site [chemical binding]; other site 644651010626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651010627 D-galactonate transporter; Region: 2A0114; TIGR00893 644651010628 putative substrate translocation pore; other site 644651010629 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 644651010630 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 644651010631 dimerization interface [polypeptide binding]; other site 644651010632 ligand binding site [chemical binding]; other site 644651010633 NADP binding site [chemical binding]; other site 644651010634 catalytic site [active] 644651010635 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 644651010636 active site 644651010637 catalytic residues [active] 644651010638 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 644651010639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644651010640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644651010641 homodimer interface [polypeptide binding]; other site 644651010642 catalytic residue [active] 644651010643 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 644651010644 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 644651010645 putative dimer interface [polypeptide binding]; other site 644651010646 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 644651010647 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 644651010648 sugar phosphate phosphatase; Provisional; Region: PRK10513 644651010649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651010650 active site 644651010651 motif I; other site 644651010652 motif II; other site 644651010653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644651010654 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 644651010655 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 644651010656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644651010657 ATP binding site [chemical binding]; other site 644651010658 Mg2+ binding site [ion binding]; other site 644651010659 G-X-G motif; other site 644651010660 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 644651010661 anchoring element; other site 644651010662 dimer interface [polypeptide binding]; other site 644651010663 ATP binding site [chemical binding]; other site 644651010664 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 644651010665 active site 644651010666 putative metal-binding site [ion binding]; other site 644651010667 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 644651010668 recF protein; Region: recf; TIGR00611 644651010669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651010670 Walker A/P-loop; other site 644651010671 ATP binding site [chemical binding]; other site 644651010672 Q-loop/lid; other site 644651010673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644651010674 ABC transporter signature motif; other site 644651010675 Walker B; other site 644651010676 D-loop; other site 644651010677 H-loop/switch region; other site 644651010678 DNA polymerase III subunit beta; Validated; Region: PRK05643 644651010679 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 644651010680 putative DNA binding surface [nucleotide binding]; other site 644651010681 dimer interface [polypeptide binding]; other site 644651010682 beta-clamp/clamp loader binding surface; other site 644651010683 beta-clamp/translesion DNA polymerase binding surface; other site 644651010684 DnaA N-terminal domain; Region: DnaA_N; pfam11638 644651010685 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 644651010686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644651010687 Walker A motif; other site 644651010688 ATP binding site [chemical binding]; other site 644651010689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 644651010690 Walker B motif; other site 644651010691 arginine finger; other site 644651010692 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 644651010693 DnaA box-binding interface [nucleotide binding]; other site 644651010694 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 644651010695 ribonuclease P; Reviewed; Region: rnpA; PRK01732 644651010696 membrane protein insertase; Provisional; Region: PRK01318 644651010697 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 644651010698 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 644651010699 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 644651010700 trmE is a tRNA modification GTPase; Region: trmE; cd04164 644651010701 G1 box; other site 644651010702 GTP/Mg2+ binding site [chemical binding]; other site 644651010703 Switch I region; other site 644651010704 G2 box; other site 644651010705 Switch II region; other site 644651010706 G3 box; other site 644651010707 G4 box; other site 644651010708 G5 box; other site 644651010709 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 644651010710 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 644651010711 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 644651010712 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 644651010713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644651010714 transcriptional regulator PhoU; Provisional; Region: PRK11115 644651010715 PhoU domain; Region: PhoU; pfam01895 644651010716 PhoU domain; Region: PhoU; pfam01895 644651010717 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 644651010718 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 644651010719 Walker A/P-loop; other site 644651010720 ATP binding site [chemical binding]; other site 644651010721 Q-loop/lid; other site 644651010722 ABC transporter signature motif; other site 644651010723 Walker B; other site 644651010724 D-loop; other site 644651010725 H-loop/switch region; other site 644651010726 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 644651010727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651010728 dimer interface [polypeptide binding]; other site 644651010729 conserved gate region; other site 644651010730 putative PBP binding loops; other site 644651010731 ABC-ATPase subunit interface; other site 644651010732 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 644651010733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651010734 dimer interface [polypeptide binding]; other site 644651010735 conserved gate region; other site 644651010736 putative PBP binding loops; other site 644651010737 ABC-ATPase subunit interface; other site 644651010738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644651010739 substrate binding pocket [chemical binding]; other site 644651010740 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 644651010741 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 644651010742 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 644651010743 glutaminase active site [active] 644651010744 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 644651010745 dimer interface [polypeptide binding]; other site 644651010746 active site 644651010747 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 644651010748 dimer interface [polypeptide binding]; other site 644651010749 active site 644651010750 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 644651010751 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 644651010752 Substrate binding site; other site 644651010753 Mg++ binding site; other site 644651010754 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 644651010755 active site 644651010756 substrate binding site [chemical binding]; other site 644651010757 CoA binding site [chemical binding]; other site 644651010758 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 644651010759 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 644651010760 gamma subunit interface [polypeptide binding]; other site 644651010761 epsilon subunit interface [polypeptide binding]; other site 644651010762 LBP interface [polypeptide binding]; other site 644651010763 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 644651010764 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 644651010765 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 644651010766 alpha subunit interaction interface [polypeptide binding]; other site 644651010767 Walker A motif; other site 644651010768 ATP binding site [chemical binding]; other site 644651010769 Walker B motif; other site 644651010770 inhibitor binding site; inhibition site 644651010771 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644651010772 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 644651010773 core domain interface [polypeptide binding]; other site 644651010774 delta subunit interface [polypeptide binding]; other site 644651010775 epsilon subunit interface [polypeptide binding]; other site 644651010776 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 644651010777 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 644651010778 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 644651010779 beta subunit interaction interface [polypeptide binding]; other site 644651010780 Walker A motif; other site 644651010781 ATP binding site [chemical binding]; other site 644651010782 Walker B motif; other site 644651010783 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644651010784 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 644651010785 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 644651010786 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 644651010787 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 644651010788 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 644651010789 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 644651010790 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 644651010791 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 644651010792 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 644651010793 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 644651010794 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 644651010795 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 644651010796 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 644651010797 Rop protein; Region: Rop; pfam01815 644651010798 Initiator Replication protein; Region: Rep_3; pfam01051 644651010799 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 644651010800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 644651010801 MULE transposase domain; Region: MULE; pfam10551 644651010802 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 644651010803 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 644651010804 outer membrane protease; Reviewed; Region: PRK10993 644651010805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644651010806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644651010807 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 644651010808 putative dimerization interface [polypeptide binding]; other site 644651010809 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 644651010810 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 644651010811 NAD(P) binding site [chemical binding]; other site 644651010812 catalytic residues [active] 644651010813 potential frameshift: common BLAST hit: gi|31790981|ref|NP_857616.1| CtpE 644651010814 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 644651010815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644651010816 dimer interface [polypeptide binding]; other site 644651010817 putative CheW interface [polypeptide binding]; other site 644651010818 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 644651010819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644651010820 non-specific DNA binding site [nucleotide binding]; other site 644651010821 salt bridge; other site 644651010822 sequence-specific DNA binding site [nucleotide binding]; other site 644651010823 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 644651010824 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 644651010825 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 644651010826 primosomal protein DnaI; Provisional; Region: PRK02854 644651010827 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 644651010828 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 644651010829 ATP binding site [chemical binding]; other site 644651010830 substrate interface [chemical binding]; other site 644651010831 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644651010832 active site residue [active] 644651010833 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 644651010834 ThiS interaction site; other site 644651010835 putative active site [active] 644651010836 tetramer interface [polypeptide binding]; other site 644651010837 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 644651010838 thiS-thiF/thiG interaction site; other site 644651010839 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 644651010840 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644651010841 multiple promoter invertase; Provisional; Region: mpi; PRK13413 644651010842 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 644651010843 catalytic residues [active] 644651010844 catalytic nucleophile [active] 644651010845 Presynaptic Site I dimer interface [polypeptide binding]; other site 644651010846 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 644651010847 Synaptic Flat tetramer interface [polypeptide binding]; other site 644651010848 Synaptic Site I dimer interface [polypeptide binding]; other site 644651010849 DNA binding site [nucleotide binding] 644651010850 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644651010851 DNA-binding interface [nucleotide binding]; DNA binding site 644651010852 Methyltransferase domain; Region: Methyltransf_12; pfam08242 644651010853 choline transport protein BetT; Provisional; Region: PRK09928 644651010854 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 644651010855 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 644651010856 potential frameshift: common BLAST hit: gi|27228701|ref|NP_758752.1| putative ABC transporter, ATP binding protein 644651010857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644651010858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644651010859 ABC-ATPase subunit interface; other site 644651010860 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 644651010861 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 644651010862 Q-loop/lid; other site 644651010863 ABC transporter signature motif; other site 644651010864 Walker B; other site 644651010865 D-loop; other site 644651010866 H-loop/switch region; other site 644651010867 NIL domain; Region: NIL; pfam09383 644651010868 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 644651010869 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 644651010870 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 644651010871 multiple promoter invertase; Provisional; Region: mpi; PRK13413 644651010872 catalytic residues [active] 644651010873 catalytic nucleophile [active] 644651010874 Presynaptic Site I dimer interface [polypeptide binding]; other site 644651010875 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 644651010876 Synaptic Flat tetramer interface [polypeptide binding]; other site 644651010877 Synaptic Site I dimer interface [polypeptide binding]; other site 644651010878 DNA binding site [nucleotide binding] 644651010879 Integrase core domain; Region: rve; pfam00665 644651010880 Integrase core domain; Region: rve_2; pfam13333 644651010881 Transposase; Region: HTH_Tnp_1; cl17663 644651010882 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 644651010883 methionine sulfoxide reductase A; Provisional; Region: PRK14054 644651010884 Winged helix-turn helix; Region: HTH_29; pfam13551 644651010885 Helix-turn-helix domain; Region: HTH_28; pfam13518 644651010886 ParA-like protein; Provisional; Region: PHA02518 644651010887 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644651010888 Magnesium ion binding site [ion binding]; other site 644651010889 ParG; Region: ParG; pfam09274