-- dump date 20140619_080801 -- class Genbank::misc_feature -- table misc_feature_note -- id note 585055000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 585055000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585055000003 putative catalytic residues [active] 585055000004 putative nucleotide binding site [chemical binding]; other site 585055000005 putative aspartate binding site [chemical binding]; other site 585055000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 585055000007 dimer interface [polypeptide binding]; other site 585055000008 putative threonine allosteric regulatory site; other site 585055000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 585055000010 putative threonine allosteric regulatory site; other site 585055000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585055000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585055000013 homoserine kinase; Region: thrB; TIGR00191 585055000014 Protein of unknown function; Region: YhfT; pfam10797 585055000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585055000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 585055000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 585055000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055000019 catalytic residue [active] 585055000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585055000021 hypothetical protein; Validated; Region: PRK02101 585055000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 585055000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 585055000024 transaldolase-like protein; Provisional; Region: PTZ00411 585055000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585055000026 active site 585055000027 dimer interface [polypeptide binding]; other site 585055000028 catalytic residue [active] 585055000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585055000030 MPT binding site; other site 585055000031 trimer interface [polypeptide binding]; other site 585055000032 hypothetical protein; Provisional; Region: PRK10659 585055000033 hypothetical protein; Provisional; Region: PRK10236 585055000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 585055000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 585055000036 hypothetical protein; Provisional; Region: PRK10154 585055000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 585055000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 585055000039 nucleotide binding site [chemical binding]; other site 585055000040 NEF interaction site [polypeptide binding]; other site 585055000041 SBD interface [polypeptide binding]; other site 585055000042 chaperone protein DnaJ; Provisional; Region: PRK10767 585055000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585055000044 HSP70 interaction site [polypeptide binding]; other site 585055000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 585055000046 substrate binding site [polypeptide binding]; other site 585055000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585055000048 Zn binding sites [ion binding]; other site 585055000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585055000050 dimer interface [polypeptide binding]; other site 585055000051 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 585055000052 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 585055000053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055000054 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 585055000055 putative dimerization interface [polypeptide binding]; other site 585055000056 fragment of fimbrial biogenesis outer membrane usher protein (partial);Evidence 7 : Gene remnant; Product type pm : membrane component 585055000057 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055000058 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 585055000059 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 585055000060 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 585055000061 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 585055000062 active site 585055000063 Riboflavin kinase; Region: Flavokinase; smart00904 585055000064 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 585055000065 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585055000066 HIGH motif; other site 585055000067 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585055000068 active site 585055000069 KMSKS motif; other site 585055000070 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 585055000071 tRNA binding surface [nucleotide binding]; other site 585055000072 anticodon binding site; other site 585055000073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585055000074 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 585055000075 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585055000076 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585055000077 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 585055000078 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 585055000079 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585055000080 active site 585055000081 tetramer interface [polypeptide binding]; other site 585055000082 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 585055000083 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 585055000084 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 585055000085 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 585055000086 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 585055000087 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 585055000088 catalytic site [active] 585055000089 subunit interface [polypeptide binding]; other site 585055000090 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 585055000091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585055000092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585055000093 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 585055000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585055000095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 585055000096 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 585055000097 IMP binding site; other site 585055000098 dimer interface [polypeptide binding]; other site 585055000099 interdomain contacts; other site 585055000100 partial ornithine binding site; other site 585055000101 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 585055000102 carnitine operon protein CaiE; Provisional; Region: PRK13627 585055000103 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585055000104 putative trimer interface [polypeptide binding]; other site 585055000105 putative metal binding site [ion binding]; other site 585055000106 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 585055000107 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585055000108 substrate binding site [chemical binding]; other site 585055000109 oxyanion hole (OAH) forming residues; other site 585055000110 trimer interface [polypeptide binding]; other site 585055000111 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 585055000112 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 585055000113 acyl-activating enzyme (AAE) consensus motif; other site 585055000114 putative AMP binding site [chemical binding]; other site 585055000115 putative active site [active] 585055000116 putative CoA binding site [chemical binding]; other site 585055000117 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 585055000118 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585055000119 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 585055000120 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585055000121 active site 585055000122 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 585055000123 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585055000124 Ligand binding site [chemical binding]; other site 585055000125 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585055000126 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 585055000127 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 585055000128 Ligand binding site [chemical binding]; other site 585055000129 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585055000130 putative oxidoreductase FixC; Provisional; Region: PRK10157 585055000131 ferredoxin-like protein FixX; Provisional; Region: PRK15449 585055000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055000133 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 585055000134 putative substrate translocation pore; other site 585055000135 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 585055000136 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 585055000137 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585055000138 TrkA-N domain; Region: TrkA_N; pfam02254 585055000139 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 585055000140 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 585055000141 folate binding site [chemical binding]; other site 585055000142 NADP+ binding site [chemical binding]; other site 585055000143 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 585055000144 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 585055000145 active site 585055000146 metal binding site [ion binding]; metal-binding site 585055000147 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 585055000148 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 585055000149 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 585055000150 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 585055000151 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 585055000152 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 585055000153 SurA N-terminal domain; Region: SurA_N; pfam09312 585055000154 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585055000155 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585055000156 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 585055000157 OstA-like protein; Region: OstA; pfam03968 585055000158 Organic solvent tolerance protein; Region: OstA_C; pfam04453 585055000159 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585055000160 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 585055000161 putative metal binding site [ion binding]; other site 585055000162 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585055000163 HSP70 interaction site [polypeptide binding]; other site 585055000164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585055000165 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585055000166 active site 585055000167 ATP-dependent helicase HepA; Validated; Region: PRK04914 585055000168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055000169 ATP binding site [chemical binding]; other site 585055000170 putative Mg++ binding site [ion binding]; other site 585055000171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055000172 nucleotide binding region [chemical binding]; other site 585055000173 ATP-binding site [chemical binding]; other site 585055000174 DNA polymerase II; Reviewed; Region: PRK05762 585055000175 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 585055000176 active site 585055000177 catalytic site [active] 585055000178 substrate binding site [chemical binding]; other site 585055000179 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 585055000180 active site 585055000181 metal-binding site 585055000182 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585055000183 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585055000184 intersubunit interface [polypeptide binding]; other site 585055000185 active site 585055000186 Zn2+ binding site [ion binding]; other site 585055000187 L-arabinose isomerase; Provisional; Region: PRK02929 585055000188 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 585055000189 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 585055000190 trimer interface [polypeptide binding]; other site 585055000191 putative substrate binding site [chemical binding]; other site 585055000192 putative metal binding site [ion binding]; other site 585055000193 ribulokinase; Provisional; Region: PRK04123 585055000194 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 585055000195 N- and C-terminal domain interface [polypeptide binding]; other site 585055000196 active site 585055000197 MgATP binding site [chemical binding]; other site 585055000198 catalytic site [active] 585055000199 metal binding site [ion binding]; metal-binding site 585055000200 carbohydrate binding site [chemical binding]; other site 585055000201 homodimer interface [polypeptide binding]; other site 585055000202 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 585055000203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585055000204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055000206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585055000207 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585055000208 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 585055000209 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 585055000210 Walker A/P-loop; other site 585055000211 ATP binding site [chemical binding]; other site 585055000212 Q-loop/lid; other site 585055000213 ABC transporter signature motif; other site 585055000214 Walker B; other site 585055000215 D-loop; other site 585055000216 H-loop/switch region; other site 585055000217 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 585055000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055000219 dimer interface [polypeptide binding]; other site 585055000220 conserved gate region; other site 585055000221 putative PBP binding loops; other site 585055000222 ABC-ATPase subunit interface; other site 585055000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055000224 dimer interface [polypeptide binding]; other site 585055000225 conserved gate region; other site 585055000226 putative PBP binding loops; other site 585055000227 ABC-ATPase subunit interface; other site 585055000228 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 585055000229 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 585055000230 transcriptional regulator SgrR; Provisional; Region: PRK13626 585055000231 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585055000232 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 585055000233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055000234 sugar efflux transporter; Region: 2A0120; TIGR00899 585055000235 putative substrate translocation pore; other site 585055000236 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 585055000237 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 585055000238 substrate binding site [chemical binding]; other site 585055000239 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 585055000240 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 585055000241 substrate binding site [chemical binding]; other site 585055000242 ligand binding site [chemical binding]; other site 585055000243 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 585055000244 tartrate dehydrogenase; Region: TTC; TIGR02089 585055000245 2-isopropylmalate synthase; Validated; Region: PRK00915 585055000246 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 585055000247 active site 585055000248 catalytic residues [active] 585055000249 metal binding site [ion binding]; metal-binding site 585055000250 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 585055000251 leu operon leader peptide; Provisional; Region: PRK09925 585055000252 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 585055000253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055000254 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 585055000255 putative substrate binding pocket [chemical binding]; other site 585055000256 putative dimerization interface [polypeptide binding]; other site 585055000257 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 585055000258 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585055000259 PYR/PP interface [polypeptide binding]; other site 585055000260 dimer interface [polypeptide binding]; other site 585055000261 TPP binding site [chemical binding]; other site 585055000262 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585055000263 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585055000264 TPP-binding site [chemical binding]; other site 585055000265 dimer interface [polypeptide binding]; other site 585055000266 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 585055000267 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585055000268 putative valine binding site [chemical binding]; other site 585055000269 dimer interface [polypeptide binding]; other site 585055000270 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 585055000271 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 585055000272 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055000273 DNA binding site [nucleotide binding] 585055000274 domain linker motif; other site 585055000275 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 585055000276 dimerization interface [polypeptide binding]; other site 585055000277 ligand binding site [chemical binding]; other site 585055000278 mraZ protein; Region: TIGR00242 585055000279 MraZ protein; Region: MraZ; pfam02381 585055000280 MraZ protein; Region: MraZ; pfam02381 585055000281 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 585055000282 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 585055000283 cell division protein FtsL; Provisional; Region: PRK10772 585055000284 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 585055000285 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585055000286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585055000287 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 585055000288 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585055000289 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585055000290 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585055000291 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 585055000292 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585055000293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585055000294 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585055000295 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 585055000296 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 585055000297 Mg++ binding site [ion binding]; other site 585055000298 putative catalytic motif [active] 585055000299 putative substrate binding site [chemical binding]; other site 585055000300 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 585055000301 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585055000302 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585055000303 cell division protein FtsW; Provisional; Region: PRK10774 585055000304 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 585055000305 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 585055000306 active site 585055000307 homodimer interface [polypeptide binding]; other site 585055000308 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 585055000309 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585055000310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585055000311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585055000312 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 585055000313 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585055000314 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585055000315 cell division protein FtsQ; Provisional; Region: PRK10775 585055000316 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 585055000317 Cell division protein FtsQ; Region: FtsQ; pfam03799 585055000318 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 585055000319 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055000320 Cell division protein FtsA; Region: FtsA; pfam14450 585055000321 cell division protein FtsZ; Validated; Region: PRK09330 585055000322 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 585055000323 nucleotide binding site [chemical binding]; other site 585055000324 SulA interaction site; other site 585055000325 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 585055000326 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 585055000327 SecA regulator SecM; Provisional; Region: PRK02943 585055000328 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 585055000329 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 585055000330 SEC-C motif; Region: SEC-C; pfam02810 585055000331 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585055000332 active site 585055000333 8-oxo-dGMP binding site [chemical binding]; other site 585055000334 nudix motif; other site 585055000335 metal binding site [ion binding]; metal-binding site 585055000336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 585055000337 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 585055000338 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 585055000339 CoA-binding site [chemical binding]; other site 585055000340 ATP-binding [chemical binding]; other site 585055000341 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 585055000342 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585055000343 active site 585055000344 type IV pilin biogenesis protein; Provisional; Region: PRK10573 585055000345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585055000346 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585055000347 hypothetical protein; Provisional; Region: PRK10436 585055000348 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585055000349 Walker A motif; other site 585055000350 ATP binding site [chemical binding]; other site 585055000351 Walker B motif; other site 585055000352 putative major pilin subunit; Provisional; Region: PRK10574 585055000353 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585055000354 Pilin (bacterial filament); Region: Pilin; pfam00114 585055000355 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 585055000356 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 585055000357 dimerization interface [polypeptide binding]; other site 585055000358 active site 585055000359 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585055000360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585055000361 amidase catalytic site [active] 585055000362 Zn binding residues [ion binding]; other site 585055000363 substrate binding site [chemical binding]; other site 585055000364 regulatory protein AmpE; Provisional; Region: PRK10987 585055000365 aromatic amino acid transporter; Provisional; Region: PRK10238 585055000366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585055000367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055000368 DNA-binding site [nucleotide binding]; DNA binding site 585055000369 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585055000370 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 585055000371 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 585055000372 dimer interface [polypeptide binding]; other site 585055000373 TPP-binding site [chemical binding]; other site 585055000374 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 585055000375 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585055000376 E3 interaction surface; other site 585055000377 lipoyl attachment site [posttranslational modification]; other site 585055000378 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585055000379 E3 interaction surface; other site 585055000380 lipoyl attachment site [posttranslational modification]; other site 585055000381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585055000382 E3 interaction surface; other site 585055000383 lipoyl attachment site [posttranslational modification]; other site 585055000384 e3 binding domain; Region: E3_binding; pfam02817 585055000385 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585055000386 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 585055000387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585055000388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055000389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585055000390 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 585055000391 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 585055000392 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 585055000393 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 585055000394 substrate binding site [chemical binding]; other site 585055000395 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 585055000396 substrate binding site [chemical binding]; other site 585055000397 ligand binding site [chemical binding]; other site 585055000398 hypothetical protein; Provisional; Region: PRK05248 585055000399 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 585055000400 spermidine synthase; Provisional; Region: PRK00811 585055000401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055000402 S-adenosylmethionine binding site [chemical binding]; other site 585055000403 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 585055000404 multicopper oxidase; Provisional; Region: PRK10965 585055000405 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585055000406 Multicopper oxidase; Region: Cu-oxidase; pfam00394 585055000407 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585055000408 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 585055000409 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 585055000410 Trp docking motif [polypeptide binding]; other site 585055000411 putative active site [active] 585055000412 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055000413 active site 585055000414 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 585055000415 active site clefts [active] 585055000416 zinc binding site [ion binding]; other site 585055000417 dimer interface [polypeptide binding]; other site 585055000418 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585055000419 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585055000420 Walker A/P-loop; other site 585055000421 ATP binding site [chemical binding]; other site 585055000422 Q-loop/lid; other site 585055000423 ABC transporter signature motif; other site 585055000424 Walker B; other site 585055000425 D-loop; other site 585055000426 H-loop/switch region; other site 585055000427 inner membrane transport permease; Provisional; Region: PRK15066 585055000428 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585055000429 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585055000430 active pocket/dimerization site; other site 585055000431 active site 585055000432 phosphorylation site [posttranslational modification] 585055000433 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 585055000434 putative active site [active] 585055000435 putative metal binding site [ion binding]; other site 585055000436 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 585055000437 tetramerization interface [polypeptide binding]; other site 585055000438 active site 585055000439 Uncharacterized conserved protein [Function unknown]; Region: COG5464 585055000440 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585055000441 pantoate--beta-alanine ligase; Region: panC; TIGR00018 585055000442 Pantoate-beta-alanine ligase; Region: PanC; cd00560 585055000443 active site 585055000444 ATP-binding site [chemical binding]; other site 585055000445 pantoate-binding site; other site 585055000446 HXXH motif; other site 585055000447 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 585055000448 oligomerization interface [polypeptide binding]; other site 585055000449 active site 585055000450 metal binding site [ion binding]; metal-binding site 585055000451 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 585055000452 putative fimbrial protein StaF; Provisional; Region: PRK15262 585055000453 putative fimbrial protein StaE; Provisional; Region: PRK15263 585055000454 Fimbrial protein; Region: Fimbrial; cl01416 585055000455 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 585055000456 PapC N-terminal domain; Region: PapC_N; pfam13954 585055000457 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055000458 PapC C-terminal domain; Region: PapC_C; pfam13953 585055000459 putative chaperone protein EcpD; Provisional; Region: PRK09926 585055000460 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055000461 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055000462 Fimbrial protein; Region: Fimbrial; cl01416 585055000463 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 585055000464 catalytic center binding site [active] 585055000465 ATP binding site [chemical binding]; other site 585055000466 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 585055000467 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585055000468 active site 585055000469 NTP binding site [chemical binding]; other site 585055000470 metal binding triad [ion binding]; metal-binding site 585055000471 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585055000472 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 585055000473 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 585055000474 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 585055000475 active site 585055000476 nucleotide binding site [chemical binding]; other site 585055000477 HIGH motif; other site 585055000478 KMSKS motif; other site 585055000479 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 585055000480 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 585055000481 2'-5' RNA ligase; Provisional; Region: PRK15124 585055000482 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585055000483 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585055000484 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 585055000485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055000486 ATP binding site [chemical binding]; other site 585055000487 putative Mg++ binding site [ion binding]; other site 585055000488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055000489 nucleotide binding region [chemical binding]; other site 585055000490 ATP-binding site [chemical binding]; other site 585055000491 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 585055000492 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 585055000493 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 585055000494 Transglycosylase; Region: Transgly; pfam00912 585055000495 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585055000496 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 585055000497 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055000498 N-terminal plug; other site 585055000499 ligand-binding site [chemical binding]; other site 585055000500 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 585055000501 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585055000502 Walker A/P-loop; other site 585055000503 ATP binding site [chemical binding]; other site 585055000504 Q-loop/lid; other site 585055000505 ABC transporter signature motif; other site 585055000506 Walker B; other site 585055000507 D-loop; other site 585055000508 H-loop/switch region; other site 585055000509 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585055000510 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 585055000511 siderophore binding site; other site 585055000512 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585055000513 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055000514 ABC-ATPase subunit interface; other site 585055000515 dimer interface [polypeptide binding]; other site 585055000516 putative PBP binding regions; other site 585055000517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055000518 ABC-ATPase subunit interface; other site 585055000519 dimer interface [polypeptide binding]; other site 585055000520 putative PBP binding regions; other site 585055000521 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 585055000522 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585055000523 inhibitor-cofactor binding pocket; inhibition site 585055000524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055000525 catalytic residue [active] 585055000526 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585055000527 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 585055000528 Cl- selectivity filter; other site 585055000529 Cl- binding residues [ion binding]; other site 585055000530 pore gating glutamate residue; other site 585055000531 dimer interface [polypeptide binding]; other site 585055000532 H+/Cl- coupling transport residue; other site 585055000533 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 585055000534 hypothetical protein; Provisional; Region: PRK10578 585055000535 UPF0126 domain; Region: UPF0126; pfam03458 585055000536 UPF0126 domain; Region: UPF0126; pfam03458 585055000537 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 585055000538 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 585055000539 cobalamin binding residues [chemical binding]; other site 585055000540 putative BtuC binding residues; other site 585055000541 dimer interface [polypeptide binding]; other site 585055000542 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 585055000543 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 585055000544 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 585055000545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585055000546 Zn2+ binding site [ion binding]; other site 585055000547 Mg2+ binding site [ion binding]; other site 585055000548 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 585055000549 serine endoprotease; Provisional; Region: PRK10942 585055000550 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585055000551 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585055000552 protein binding site [polypeptide binding]; other site 585055000553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585055000554 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 585055000555 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 585055000556 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 585055000557 hypothetical protein; Provisional; Region: PRK13677 585055000558 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 585055000559 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 585055000560 trimer interface [polypeptide binding]; other site 585055000561 active site 585055000562 substrate binding site [chemical binding]; other site 585055000563 CoA binding site [chemical binding]; other site 585055000564 PII uridylyl-transferase; Provisional; Region: PRK05007 585055000565 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585055000566 metal binding triad; other site 585055000567 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585055000568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585055000569 Zn2+ binding site [ion binding]; other site 585055000570 Mg2+ binding site [ion binding]; other site 585055000571 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 585055000572 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 585055000573 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 585055000574 active site 585055000575 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 585055000576 rRNA interaction site [nucleotide binding]; other site 585055000577 S8 interaction site; other site 585055000578 putative laminin-1 binding site; other site 585055000579 elongation factor Ts; Provisional; Region: tsf; PRK09377 585055000580 UBA/TS-N domain; Region: UBA; pfam00627 585055000581 Elongation factor TS; Region: EF_TS; pfam00889 585055000582 Elongation factor TS; Region: EF_TS; pfam00889 585055000583 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 585055000584 putative nucleotide binding site [chemical binding]; other site 585055000585 uridine monophosphate binding site [chemical binding]; other site 585055000586 homohexameric interface [polypeptide binding]; other site 585055000587 ribosome recycling factor; Reviewed; Region: frr; PRK00083 585055000588 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 585055000589 hinge region; other site 585055000590 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 585055000591 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 585055000592 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 585055000593 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 585055000594 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 585055000595 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 585055000596 catalytic residue [active] 585055000597 putative FPP diphosphate binding site; other site 585055000598 putative FPP binding hydrophobic cleft; other site 585055000599 dimer interface [polypeptide binding]; other site 585055000600 putative IPP diphosphate binding site; other site 585055000601 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 585055000602 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585055000603 zinc metallopeptidase RseP; Provisional; Region: PRK10779 585055000604 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585055000605 active site 585055000606 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 585055000607 protein binding site [polypeptide binding]; other site 585055000608 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585055000609 putative substrate binding region [chemical binding]; other site 585055000610 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 585055000611 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585055000612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585055000613 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585055000614 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585055000615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585055000616 Surface antigen; Region: Bac_surface_Ag; pfam01103 585055000617 periplasmic chaperone; Provisional; Region: PRK10780 585055000618 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 585055000619 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 585055000620 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 585055000621 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 585055000622 trimer interface [polypeptide binding]; other site 585055000623 active site 585055000624 UDP-GlcNAc binding site [chemical binding]; other site 585055000625 lipid binding site [chemical binding]; lipid-binding site 585055000626 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 585055000627 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 585055000628 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 585055000629 active site 585055000630 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 585055000631 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 585055000632 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 585055000633 RNA/DNA hybrid binding site [nucleotide binding]; other site 585055000634 active site 585055000635 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 585055000636 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 585055000637 putative active site [active] 585055000638 putative PHP Thumb interface [polypeptide binding]; other site 585055000639 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 585055000640 generic binding surface II; other site 585055000641 generic binding surface I; other site 585055000642 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 585055000643 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 585055000644 lysine decarboxylase LdcC; Provisional; Region: PRK15399 585055000645 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585055000646 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585055000647 homodimer interface [polypeptide binding]; other site 585055000648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055000649 catalytic residue [active] 585055000650 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585055000651 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 585055000652 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585055000653 putative metal binding site [ion binding]; other site 585055000654 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 585055000655 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 585055000656 Ligand Binding Site [chemical binding]; other site 585055000657 TilS substrate binding domain; Region: TilS; pfam09179 585055000658 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 585055000659 Rho-binding antiterminator; Provisional; Region: PRK11625 585055000660 hypothetical protein; Provisional; Region: PRK04964 585055000661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 585055000662 hypothetical protein; Provisional; Region: PRK09256 585055000663 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585055000664 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 585055000665 NlpE N-terminal domain; Region: NlpE; pfam04170 585055000666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055000667 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055000668 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055000669 fragment of lipoprotein (part 2);Evidence 7 : Gene remnant; Product type lp : lipoprotein 585055000670 fragment of lipoprotein (part 1);Evidence 7 : Gene remnant; Product type lp : lipoprotein 585055000671 prolyl-tRNA synthetase; Provisional; Region: PRK09194 585055000672 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 585055000673 dimer interface [polypeptide binding]; other site 585055000674 motif 1; other site 585055000675 active site 585055000676 motif 2; other site 585055000677 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 585055000678 putative deacylase active site [active] 585055000679 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585055000680 active site 585055000681 motif 3; other site 585055000682 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 585055000683 anticodon binding site; other site 585055000684 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 585055000685 homodimer interaction site [polypeptide binding]; other site 585055000686 cofactor binding site; other site 585055000687 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 585055000688 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 585055000689 lipoprotein, YaeC family; Region: TIGR00363 585055000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055000691 dimer interface [polypeptide binding]; other site 585055000692 conserved gate region; other site 585055000693 ABC-ATPase subunit interface; other site 585055000694 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 585055000695 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 585055000696 Walker A/P-loop; other site 585055000697 ATP binding site [chemical binding]; other site 585055000698 Q-loop/lid; other site 585055000699 ABC transporter signature motif; other site 585055000700 Walker B; other site 585055000701 D-loop; other site 585055000702 H-loop/switch region; other site 585055000703 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 585055000704 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 585055000705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055000706 active site 585055000707 motif I; other site 585055000708 motif II; other site 585055000709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055000710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055000711 active site 585055000712 catalytic tetrad [active] 585055000713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055000714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055000715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055000716 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 585055000717 putative effector binding pocket; other site 585055000718 dimerization interface [polypeptide binding]; other site 585055000719 hypothetical protein; Provisional; Region: PRK05421 585055000720 putative catalytic site [active] 585055000721 putative metal binding site [ion binding]; other site 585055000722 putative phosphate binding site [ion binding]; other site 585055000723 putative catalytic site [active] 585055000724 putative phosphate binding site [ion binding]; other site 585055000725 putative metal binding site [ion binding]; other site 585055000726 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585055000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055000728 S-adenosylmethionine binding site [chemical binding]; other site 585055000729 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 585055000730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585055000731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585055000732 catalytic residue [active] 585055000733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055000734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055000735 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 585055000736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055000737 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 585055000738 RNA/DNA hybrid binding site [nucleotide binding]; other site 585055000739 active site 585055000740 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 585055000741 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 585055000742 active site 585055000743 catalytic site [active] 585055000744 substrate binding site [chemical binding]; other site 585055000745 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585055000746 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585055000747 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585055000748 ImpA domain protein; Region: DUF3702; pfam12486 585055000749 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 585055000750 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 585055000751 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 585055000752 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585055000753 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585055000754 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585055000755 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 585055000756 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585055000757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055000758 Walker A motif; other site 585055000759 ATP binding site [chemical binding]; other site 585055000760 Walker B motif; other site 585055000761 arginine finger; other site 585055000762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055000763 Walker A motif; other site 585055000764 ATP binding site [chemical binding]; other site 585055000765 Walker B motif; other site 585055000766 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585055000767 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 585055000768 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 585055000769 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585055000770 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 585055000771 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 585055000772 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 585055000773 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585055000774 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585055000775 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585055000776 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 585055000777 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585055000778 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 585055000779 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585055000780 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585055000781 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585055000782 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585055000783 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585055000784 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585055000785 fragment of Rhs Core protein (part 1);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055000786 fragment of rhsE element core protein RshE (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055000787 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 585055000788 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585055000789 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585055000790 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 585055000791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055000792 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585055000793 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585055000794 C-N hydrolase family amidase; Provisional; Region: PRK10438 585055000795 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 585055000796 putative active site [active] 585055000797 catalytic triad [active] 585055000798 dimer interface [polypeptide binding]; other site 585055000799 multimer interface [polypeptide binding]; other site 585055000800 C-lysozyme inhibitor; Provisional; Region: PRK09993 585055000801 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 585055000802 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 585055000803 active site 585055000804 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 585055000805 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585055000806 dimer interface [polypeptide binding]; other site 585055000807 active site 585055000808 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 585055000809 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 585055000810 putative active site [active] 585055000811 putative dimer interface [polypeptide binding]; other site 585055000812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 585055000813 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585055000814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 585055000815 RelB antitoxin; Region: RelB; cl01171 585055000816 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585055000817 NlpC/P60 family; Region: NLPC_P60; pfam00877 585055000818 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 585055000819 HicB family; Region: HicB; pfam05534 585055000820 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 585055000821 FHIPEP family; Region: FHIPEP; pfam00771 585055000822 hypothetical protein; Validated; Region: PRK06778 585055000823 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585055000824 ligand binding site [chemical binding]; other site 585055000825 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 585055000826 active site 585055000827 DNA polymerase IV; Validated; Region: PRK02406 585055000828 DNA binding site [nucleotide binding] 585055000829 fragment of acyltransferase with acyl-CoA N-acyltransferase domain (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055000830 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055000831 hypothetical protein; Reviewed; Region: PRK09588 585055000832 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 585055000833 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585055000834 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 585055000835 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 585055000836 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 585055000837 metal binding site [ion binding]; metal-binding site 585055000838 dimer interface [polypeptide binding]; other site 585055000839 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055000840 active site 585055000841 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 585055000842 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 585055000843 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585055000844 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585055000845 trimer interface [polypeptide binding]; other site 585055000846 eyelet of channel; other site 585055000847 gamma-glutamyl kinase; Provisional; Region: PRK05429 585055000848 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 585055000849 nucleotide binding site [chemical binding]; other site 585055000850 homotetrameric interface [polypeptide binding]; other site 585055000851 putative phosphate binding site [ion binding]; other site 585055000852 putative allosteric binding site; other site 585055000853 PUA domain; Region: PUA; pfam01472 585055000854 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 585055000855 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 585055000856 putative catalytic cysteine [active] 585055000857 integrase; Provisional; Region: PRK09692 585055000858 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585055000859 active site 585055000860 Int/Topo IB signature motif; other site 585055000861 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585055000862 AntA/AntB antirepressor; Region: AntA; pfam08346 585055000863 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585055000864 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 585055000865 ProQ/FINO family; Region: ProQ; pfam04352 585055000866 PerC transcriptional activator; Region: PerC; pfam06069 585055000867 Helix-turn-helix domain; Region: HTH_17; cl17695 585055000868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055000869 AAA domain; Region: AAA_21; pfam13304 585055000870 Walker A/P-loop; other site 585055000871 ATP binding site [chemical binding]; other site 585055000872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055000873 ABC transporter signature motif; other site 585055000874 Walker B; other site 585055000875 D-loop; other site 585055000876 H-loop/switch region; other site 585055000877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055000878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055000879 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 585055000880 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 585055000881 XdhC Rossmann domain; Region: XdhC_C; pfam13478 585055000882 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 585055000883 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585055000884 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585055000885 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 585055000886 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 585055000887 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 585055000888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055000889 catalytic loop [active] 585055000890 iron binding site [ion binding]; other site 585055000891 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585055000892 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 585055000893 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055000894 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 585055000895 putative fimbrial protein TcfA; Provisional; Region: PRK15308 585055000896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585055000897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055000898 DNA binding residues [nucleotide binding] 585055000899 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 585055000900 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585055000901 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585055000902 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585055000903 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585055000904 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585055000905 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585055000906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055000907 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 585055000908 Predicted membrane protein [Function unknown]; Region: COG3059 585055000909 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055000910 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 585055000911 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585055000912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055000913 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585055000914 Cupin; Region: Cupin_6; pfam12852 585055000915 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585055000916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055000917 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585055000918 Cysteine-rich domain; Region: CCG; pfam02754 585055000919 Cysteine-rich domain; Region: CCG; pfam02754 585055000920 iron-sulfur cluster-binding protein; Region: TIGR00273 585055000921 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 585055000922 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055000923 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 585055000924 Uncharacterized conserved protein [Function unknown]; Region: COG1556 585055000925 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585055000926 choline dehydrogenase; Validated; Region: PRK02106 585055000927 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 585055000928 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 585055000929 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 585055000930 tetrameric interface [polypeptide binding]; other site 585055000931 NAD binding site [chemical binding]; other site 585055000932 catalytic residues [active] 585055000933 transcriptional regulator BetI; Validated; Region: PRK00767 585055000934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055000935 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585055000936 choline transport protein BetT; Provisional; Region: PRK09928 585055000937 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585055000938 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585055000939 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055000940 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055000941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055000942 DNA binding residues [nucleotide binding] 585055000943 dimerization interface [polypeptide binding]; other site 585055000944 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055000945 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585055000946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055000947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055000948 dimerization interface [polypeptide binding]; other site 585055000949 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585055000950 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585055000951 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 585055000952 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585055000953 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585055000954 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 585055000955 CoA binding domain; Region: CoA_binding; pfam02629 585055000956 CoA-ligase; Region: Ligase_CoA; pfam00549 585055000957 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585055000958 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585055000959 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585055000960 putative substrate binding site [chemical binding]; other site 585055000961 nucleotide binding site [chemical binding]; other site 585055000962 nucleotide binding site [chemical binding]; other site 585055000963 homodimer interface [polypeptide binding]; other site 585055000964 putative deaminase; Validated; Region: PRK06846 585055000965 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585055000966 active site 585055000967 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 585055000968 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 585055000969 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585055000970 ligand binding site [chemical binding]; other site 585055000971 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585055000972 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055000973 Walker A/P-loop; other site 585055000974 ATP binding site [chemical binding]; other site 585055000975 Q-loop/lid; other site 585055000976 ABC transporter signature motif; other site 585055000977 Walker B; other site 585055000978 D-loop; other site 585055000979 H-loop/switch region; other site 585055000980 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055000981 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055000982 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055000983 TM-ABC transporter signature motif; other site 585055000984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055000985 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055000986 TM-ABC transporter signature motif; other site 585055000987 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585055000988 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585055000989 putative NAD(P) binding site [chemical binding]; other site 585055000990 putative substrate binding site [chemical binding]; other site 585055000991 catalytic Zn binding site [ion binding]; other site 585055000992 structural Zn binding site [ion binding]; other site 585055000993 dimer interface [polypeptide binding]; other site 585055000994 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 585055000995 hypothetical protein; Provisional; Region: PRK09929 585055000996 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 585055000997 Propionate catabolism activator; Region: PrpR_N; pfam06506 585055000998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055000999 Walker A motif; other site 585055001000 ATP binding site [chemical binding]; other site 585055001001 Walker B motif; other site 585055001002 arginine finger; other site 585055001003 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585055001004 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585055001005 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 585055001006 tetramer interface [polypeptide binding]; other site 585055001007 active site 585055001008 Mg2+/Mn2+ binding site [ion binding]; other site 585055001009 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585055001010 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 585055001011 dimer interface [polypeptide binding]; other site 585055001012 active site 585055001013 citrylCoA binding site [chemical binding]; other site 585055001014 oxalacetate/citrate binding site [chemical binding]; other site 585055001015 coenzyme A binding site [chemical binding]; other site 585055001016 catalytic triad [active] 585055001017 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 585055001018 2-methylcitrate dehydratase; Region: prpD; TIGR02330 585055001019 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 585055001020 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 585055001021 acyl-activating enzyme (AAE) consensus motif; other site 585055001022 putative AMP binding site [chemical binding]; other site 585055001023 putative active site [active] 585055001024 putative CoA binding site [chemical binding]; other site 585055001025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055001026 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055001027 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055001028 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 585055001029 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585055001030 Na binding site [ion binding]; other site 585055001031 putative substrate binding site [chemical binding]; other site 585055001032 cytosine deaminase; Provisional; Region: PRK09230 585055001033 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585055001034 active site 585055001035 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 585055001036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055001037 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 585055001038 dimerization interface [polypeptide binding]; other site 585055001039 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 585055001040 active site clefts [active] 585055001041 zinc binding site [ion binding]; other site 585055001042 dimer interface [polypeptide binding]; other site 585055001043 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 585055001044 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 585055001045 oligomer interface [polypeptide binding]; other site 585055001046 active site 585055001047 putative cyanate transporter; Provisional; Region: cynX; PRK09705 585055001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001049 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 585055001050 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 585055001051 active site 585055001052 substrate binding site [chemical binding]; other site 585055001053 trimer interface [polypeptide binding]; other site 585055001054 CoA binding site [chemical binding]; other site 585055001055 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 585055001056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001057 putative substrate translocation pore; other site 585055001058 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 585055001059 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585055001060 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585055001061 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585055001062 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585055001063 lac repressor; Reviewed; Region: lacI; PRK09526 585055001064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055001065 DNA binding site [nucleotide binding] 585055001066 domain linker motif; other site 585055001067 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 585055001068 ligand binding site [chemical binding]; other site 585055001069 dimerization interface (open form) [polypeptide binding]; other site 585055001070 dimerization interface (closed form) [polypeptide binding]; other site 585055001071 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 585055001072 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585055001073 Bacterial transcriptional regulator; Region: IclR; pfam01614 585055001074 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 585055001075 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585055001076 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 585055001077 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585055001078 putative active site [active] 585055001079 Fe(II) binding site [ion binding]; other site 585055001080 putative dimer interface [polypeptide binding]; other site 585055001081 putative tetramer interface [polypeptide binding]; other site 585055001082 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 585055001083 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 585055001084 nucleophilic elbow; other site 585055001085 catalytic triad; other site 585055001086 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 585055001087 acetaldehyde dehydrogenase; Validated; Region: PRK08300 585055001088 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585055001089 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 585055001090 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 585055001091 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 585055001092 active site 585055001093 catalytic residues [active] 585055001094 metal binding site [ion binding]; metal-binding site 585055001095 DmpG-like communication domain; Region: DmpG_comm; pfam07836 585055001096 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 585055001097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 585055001100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055001101 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055001102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055001103 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585055001104 S-formylglutathione hydrolase; Region: PLN02442 585055001105 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 585055001106 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 585055001107 substrate binding site [chemical binding]; other site 585055001108 catalytic Zn binding site [ion binding]; other site 585055001109 NAD binding site [chemical binding]; other site 585055001110 structural Zn binding site [ion binding]; other site 585055001111 dimer interface [polypeptide binding]; other site 585055001112 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585055001113 putative metal binding site [ion binding]; other site 585055001114 putative homodimer interface [polypeptide binding]; other site 585055001115 putative homotetramer interface [polypeptide binding]; other site 585055001116 putative homodimer-homodimer interface [polypeptide binding]; other site 585055001117 putative allosteric switch controlling residues; other site 585055001118 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585055001119 putative trimer interface [polypeptide binding]; other site 585055001120 putative CoA binding site [chemical binding]; other site 585055001121 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 585055001122 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585055001123 DXD motif; other site 585055001124 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 585055001125 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 585055001126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055001127 substrate binding pocket [chemical binding]; other site 585055001128 membrane-bound complex binding site; other site 585055001129 hinge residues; other site 585055001130 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 585055001131 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585055001132 Walker A/P-loop; other site 585055001133 ATP binding site [chemical binding]; other site 585055001134 Q-loop/lid; other site 585055001135 ABC transporter signature motif; other site 585055001136 Walker B; other site 585055001137 D-loop; other site 585055001138 H-loop/switch region; other site 585055001139 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585055001140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055001141 dimer interface [polypeptide binding]; other site 585055001142 conserved gate region; other site 585055001143 putative PBP binding loops; other site 585055001144 ABC-ATPase subunit interface; other site 585055001145 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 585055001146 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 585055001147 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 585055001148 dimer interface [polypeptide binding]; other site 585055001149 active site 585055001150 Schiff base residues; other site 585055001151 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 585055001152 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055001153 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055001154 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 585055001155 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 585055001156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585055001157 microcin B17 transporter; Reviewed; Region: PRK11098 585055001158 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 585055001159 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 585055001160 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 585055001161 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 585055001162 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585055001163 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585055001164 anti-RssB factor; Provisional; Region: PRK10244 585055001165 fragment of bacterial alkaline phosphatase (part 1);Evidence 7 : Gene remnant; Product type e : enzyme 585055001166 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055001167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055001168 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055001169 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055001170 fragment of bacterial alkaline phosphatase (part 2);Evidence 7 : Gene remnant; Product type e : enzyme 585055001171 hypothetical protein; Provisional; Region: PRK11505 585055001172 psiF repeat; Region: PsiF_repeat; pfam07769 585055001173 psiF repeat; Region: PsiF_repeat; pfam07769 585055001174 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 585055001175 MASE2 domain; Region: MASE2; pfam05230 585055001176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055001177 metal binding site [ion binding]; metal-binding site 585055001178 active site 585055001179 I-site; other site 585055001180 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 585055001181 pyrroline-5-carboxylate reductase; Region: PLN02688 585055001182 hypothetical protein; Validated; Region: PRK00124 585055001183 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 585055001184 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585055001185 ADP binding site [chemical binding]; other site 585055001186 magnesium binding site [ion binding]; other site 585055001187 putative shikimate binding site; other site 585055001188 hypothetical protein; Provisional; Region: PRK10380 585055001189 hypothetical protein; Provisional; Region: PRK10481 585055001190 hypothetical protein; Provisional; Region: PRK10579 585055001191 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 585055001192 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 585055001193 fructokinase; Reviewed; Region: PRK09557 585055001194 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055001195 nucleotide binding site [chemical binding]; other site 585055001196 MFS transport protein AraJ; Provisional; Region: PRK10091 585055001197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001198 putative substrate translocation pore; other site 585055001199 exonuclease subunit SbcC; Provisional; Region: PRK10246 585055001200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055001201 Walker A/P-loop; other site 585055001202 ATP binding site [chemical binding]; other site 585055001203 Q-loop/lid; other site 585055001204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055001205 ABC transporter signature motif; other site 585055001206 Walker B; other site 585055001207 D-loop; other site 585055001208 H-loop/switch region; other site 585055001209 exonuclease subunit SbcD; Provisional; Region: PRK10966 585055001210 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 585055001211 active site 585055001212 metal binding site [ion binding]; metal-binding site 585055001213 DNA binding site [nucleotide binding] 585055001214 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 585055001215 transcriptional regulator PhoB; Provisional; Region: PRK10161 585055001216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055001217 active site 585055001218 phosphorylation site [posttranslational modification] 585055001219 intermolecular recognition site; other site 585055001220 dimerization interface [polypeptide binding]; other site 585055001221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055001222 DNA binding site [nucleotide binding] 585055001223 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 585055001224 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 585055001225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055001226 putative active site [active] 585055001227 heme pocket [chemical binding]; other site 585055001228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055001229 dimer interface [polypeptide binding]; other site 585055001230 phosphorylation site [posttranslational modification] 585055001231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055001232 ATP binding site [chemical binding]; other site 585055001233 Mg2+ binding site [ion binding]; other site 585055001234 G-X-G motif; other site 585055001235 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 585055001236 putative proline-specific permease; Provisional; Region: proY; PRK10580 585055001237 Spore germination protein; Region: Spore_permease; cl17796 585055001238 maltodextrin glucosidase; Provisional; Region: PRK10785 585055001239 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 585055001240 homodimer interface [polypeptide binding]; other site 585055001241 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 585055001242 active site 585055001243 homodimer interface [polypeptide binding]; other site 585055001244 catalytic site [active] 585055001245 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 585055001246 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 585055001247 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 585055001248 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 585055001249 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 585055001250 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 585055001251 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 585055001252 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 585055001253 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585055001254 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 585055001255 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 585055001256 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585055001257 Protein export membrane protein; Region: SecD_SecF; pfam02355 585055001258 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585055001259 active site 585055001260 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 585055001261 fragment of lipoprotein (partial);Evidence 7 : Gene remnant; Product type lp : lipoprotein 585055001262 fragment of protein (partial);Evidence 7 : Gene remnant 585055001263 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 585055001264 ATP cone domain; Region: ATP-cone; pfam03477 585055001265 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 585055001266 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 585055001267 catalytic motif [active] 585055001268 Zn binding site [ion binding]; other site 585055001269 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 585055001270 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 585055001271 homopentamer interface [polypeptide binding]; other site 585055001272 active site 585055001273 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 585055001274 putative RNA binding site [nucleotide binding]; other site 585055001275 thiamine monophosphate kinase; Provisional; Region: PRK05731 585055001276 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 585055001277 ATP binding site [chemical binding]; other site 585055001278 dimerization interface [polypeptide binding]; other site 585055001279 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 585055001280 tetramer interfaces [polypeptide binding]; other site 585055001281 binuclear metal-binding site [ion binding]; other site 585055001282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055001283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055001284 active site 585055001285 catalytic tetrad [active] 585055001286 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 585055001287 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 585055001288 TPP-binding site; other site 585055001289 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585055001290 PYR/PP interface [polypeptide binding]; other site 585055001291 dimer interface [polypeptide binding]; other site 585055001292 TPP binding site [chemical binding]; other site 585055001293 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585055001294 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585055001295 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585055001296 substrate binding pocket [chemical binding]; other site 585055001297 chain length determination region; other site 585055001298 substrate-Mg2+ binding site; other site 585055001299 catalytic residues [active] 585055001300 aspartate-rich region 1; other site 585055001301 active site lid residues [active] 585055001302 aspartate-rich region 2; other site 585055001303 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 585055001304 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 585055001305 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 585055001306 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 585055001307 Ligand Binding Site [chemical binding]; other site 585055001308 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585055001309 active site residue [active] 585055001310 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 585055001311 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 585055001312 conserved cys residue [active] 585055001313 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 585055001314 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585055001315 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 585055001316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 585055001317 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 585055001318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055001320 putative substrate translocation pore; other site 585055001321 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585055001322 Sel1 repeat; Region: Sel1; pfam08238 585055001323 Sel1-like repeats; Region: SEL1; smart00671 585055001324 Sel1-like repeats; Region: SEL1; smart00671 585055001325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 585055001326 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 585055001327 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 585055001328 UbiA prenyltransferase family; Region: UbiA; pfam01040 585055001329 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 585055001330 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 585055001331 Subunit I/III interface [polypeptide binding]; other site 585055001332 Subunit III/IV interface [polypeptide binding]; other site 585055001333 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 585055001334 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 585055001335 D-pathway; other site 585055001336 Putative ubiquinol binding site [chemical binding]; other site 585055001337 Low-spin heme (heme b) binding site [chemical binding]; other site 585055001338 Putative water exit pathway; other site 585055001339 Binuclear center (heme o3/CuB) [ion binding]; other site 585055001340 K-pathway; other site 585055001341 Putative proton exit pathway; other site 585055001342 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 585055001343 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 585055001344 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 585055001345 muropeptide transporter; Reviewed; Region: ampG; PRK11902 585055001346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001347 putative substrate translocation pore; other site 585055001348 hypothetical protein; Provisional; Region: PRK11627 585055001349 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 585055001350 transcriptional regulator BolA; Provisional; Region: PRK11628 585055001351 trigger factor; Provisional; Region: tig; PRK01490 585055001352 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585055001353 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 585055001354 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585055001355 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 585055001356 oligomer interface [polypeptide binding]; other site 585055001357 active site residues [active] 585055001358 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 585055001359 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 585055001360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055001361 Walker A motif; other site 585055001362 ATP binding site [chemical binding]; other site 585055001363 Walker B motif; other site 585055001364 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585055001365 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 585055001366 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585055001367 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585055001368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055001369 Walker A motif; other site 585055001370 ATP binding site [chemical binding]; other site 585055001371 Walker B motif; other site 585055001372 arginine finger; other site 585055001373 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585055001374 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585055001375 IHF dimer interface [polypeptide binding]; other site 585055001376 IHF - DNA interface [nucleotide binding]; other site 585055001377 periplasmic folding chaperone; Provisional; Region: PRK10788 585055001378 SurA N-terminal domain; Region: SurA_N_3; cl07813 585055001379 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 585055001380 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 585055001381 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585055001382 active site 585055001383 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 585055001384 Ligand Binding Site [chemical binding]; other site 585055001385 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 585055001386 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585055001387 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 585055001388 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 585055001389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055001390 active site 585055001391 motif I; other site 585055001392 motif II; other site 585055001393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055001394 dimerization interface [polypeptide binding]; other site 585055001395 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 585055001396 putative DNA binding site [nucleotide binding]; other site 585055001397 putative Zn2+ binding site [ion binding]; other site 585055001398 AsnC family; Region: AsnC_trans_reg; pfam01037 585055001399 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585055001400 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 585055001401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055001402 Walker A/P-loop; other site 585055001403 ATP binding site [chemical binding]; other site 585055001404 Q-loop/lid; other site 585055001405 ABC transporter signature motif; other site 585055001406 Walker B; other site 585055001407 D-loop; other site 585055001408 H-loop/switch region; other site 585055001409 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 585055001410 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585055001411 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 585055001412 Walker A/P-loop; other site 585055001413 ATP binding site [chemical binding]; other site 585055001414 Q-loop/lid; other site 585055001415 ABC transporter signature motif; other site 585055001416 Walker B; other site 585055001417 D-loop; other site 585055001418 H-loop/switch region; other site 585055001419 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 585055001420 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585055001421 ammonium transporter; Provisional; Region: PRK10666 585055001422 acyl-CoA thioesterase II; Provisional; Region: PRK10526 585055001423 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 585055001424 active site 585055001425 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 585055001426 catalytic triad [active] 585055001427 dimer interface [polypeptide binding]; other site 585055001428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 585055001429 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 585055001430 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585055001431 DNA binding site [nucleotide binding] 585055001432 active site 585055001433 Uncharacterized conserved protein [Function unknown]; Region: COG5507 585055001434 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585055001435 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585055001436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055001437 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 585055001438 maltose O-acetyltransferase; Provisional; Region: PRK10092 585055001439 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 585055001440 active site 585055001441 substrate binding site [chemical binding]; other site 585055001442 trimer interface [polypeptide binding]; other site 585055001443 CoA binding site [chemical binding]; other site 585055001444 gene expression modulator; Provisional; Region: PRK10945 585055001445 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 585055001446 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585055001447 Protein export membrane protein; Region: SecD_SecF; cl14618 585055001448 Protein export membrane protein; Region: SecD_SecF; cl14618 585055001449 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585055001450 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055001451 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 585055001452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055001453 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585055001454 hypothetical protein; Provisional; Region: PRK11281 585055001455 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585055001456 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 585055001457 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585055001458 hypothetical protein; Provisional; Region: PRK11038 585055001459 primosomal replication protein N''; Provisional; Region: PRK10093 585055001460 hypothetical protein; Provisional; Region: PRK10527 585055001461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055001462 active site 585055001463 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 585055001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055001465 Walker A motif; other site 585055001466 ATP binding site [chemical binding]; other site 585055001467 Walker B motif; other site 585055001468 DNA polymerase III subunit delta'; Validated; Region: PRK08485 585055001469 arginine finger; other site 585055001470 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 585055001471 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 585055001472 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 585055001473 hypothetical protein; Validated; Region: PRK00153 585055001474 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 585055001475 RecR protein; Region: RecR; pfam02132 585055001476 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 585055001477 putative active site [active] 585055001478 putative metal-binding site [ion binding]; other site 585055001479 tetramer interface [polypeptide binding]; other site 585055001480 heat shock protein 90; Provisional; Region: PRK05218 585055001481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055001482 ATP binding site [chemical binding]; other site 585055001483 Mg2+ binding site [ion binding]; other site 585055001484 G-X-G motif; other site 585055001485 adenylate kinase; Reviewed; Region: adk; PRK00279 585055001486 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 585055001487 AMP-binding site [chemical binding]; other site 585055001488 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 585055001489 ferrochelatase; Region: hemH; TIGR00109 585055001490 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 585055001491 C-terminal domain interface [polypeptide binding]; other site 585055001492 active site 585055001493 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 585055001494 active site 585055001495 N-terminal domain interface [polypeptide binding]; other site 585055001496 acetyl esterase; Provisional; Region: PRK10162 585055001497 inosine/guanosine kinase; Provisional; Region: PRK15074 585055001498 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055001499 putative cation:proton antiport protein; Provisional; Region: PRK10669 585055001500 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 585055001501 TrkA-N domain; Region: TrkA_N; pfam02254 585055001502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055001504 putative substrate translocation pore; other site 585055001505 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 585055001506 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 585055001507 active site 585055001508 metal binding site [ion binding]; metal-binding site 585055001509 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585055001510 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 585055001511 putative deacylase active site [active] 585055001512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 585055001513 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585055001514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055001515 sequence-specific DNA binding site [nucleotide binding]; other site 585055001516 salt bridge; other site 585055001517 copper exporting ATPase; Provisional; Region: copA; PRK10671 585055001518 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585055001519 metal-binding site [ion binding] 585055001520 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585055001521 metal-binding site [ion binding] 585055001522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585055001523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055001524 motif II; other site 585055001525 glutaminase; Reviewed; Region: PRK12356 585055001526 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585055001527 amino acid transporter; Region: 2A0306; TIGR00909 585055001528 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 585055001529 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 585055001530 DNA binding residues [nucleotide binding] 585055001531 dimer interface [polypeptide binding]; other site 585055001532 copper binding site [ion binding]; other site 585055001533 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 585055001534 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585055001535 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585055001536 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 585055001537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055001538 Walker A/P-loop; other site 585055001539 ATP binding site [chemical binding]; other site 585055001540 Q-loop/lid; other site 585055001541 ABC transporter signature motif; other site 585055001542 Walker B; other site 585055001543 D-loop; other site 585055001544 H-loop/switch region; other site 585055001545 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 585055001546 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 585055001547 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 585055001548 oxidoreductase; Provisional; Region: PRK08017 585055001549 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 585055001550 NADP binding site [chemical binding]; other site 585055001551 active site 585055001552 steroid binding site; other site 585055001553 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 585055001554 active site 585055001555 catalytic triad [active] 585055001556 oxyanion hole [active] 585055001557 switch loop; other site 585055001558 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 585055001559 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585055001560 Walker A/P-loop; other site 585055001561 ATP binding site [chemical binding]; other site 585055001562 Q-loop/lid; other site 585055001563 ABC transporter signature motif; other site 585055001564 Walker B; other site 585055001565 D-loop; other site 585055001566 H-loop/switch region; other site 585055001567 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 585055001568 FtsX-like permease family; Region: FtsX; pfam02687 585055001569 FtsX-like permease family; Region: FtsX; pfam02687 585055001570 PAAR motif; Region: PAAR_motif; cl15808 585055001571 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055001572 RHS Repeat; Region: RHS_repeat; pfam05593 585055001573 RHS Repeat; Region: RHS_repeat; pfam05593 585055001574 RHS Repeat; Region: RHS_repeat; pfam05593 585055001575 RHS Repeat; Region: RHS_repeat; pfam05593 585055001576 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055001577 RHS Repeat; Region: RHS_repeat; pfam05593 585055001578 RHS Repeat; Region: RHS_repeat; pfam05593 585055001579 RHS protein; Region: RHS; pfam03527 585055001580 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055001581 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 585055001582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055001583 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055001584 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055001585 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055001586 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055001587 RHS protein; Region: RHS; pfam03527 585055001588 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055001589 hypothetical protein; Provisional; Region: PRK14710 585055001590 Winged helix-turn helix; Region: HTH_29; pfam13551 585055001591 Helix-turn-helix domain; Region: HTH_28; pfam13518 585055001592 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 585055001593 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 585055001594 active site residue [active] 585055001595 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585055001596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055001597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055001598 dimerization interface [polypeptide binding]; other site 585055001599 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 585055001600 ureidoglycolate hydrolase; Provisional; Region: PRK03606 585055001601 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 585055001602 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585055001603 Bacterial transcriptional regulator; Region: IclR; pfam01614 585055001604 glyoxylate carboligase; Provisional; Region: PRK11269 585055001605 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585055001606 PYR/PP interface [polypeptide binding]; other site 585055001607 dimer interface [polypeptide binding]; other site 585055001608 TPP binding site [chemical binding]; other site 585055001609 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585055001610 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 585055001611 TPP-binding site [chemical binding]; other site 585055001612 hydroxypyruvate isomerase; Provisional; Region: PRK09997 585055001613 tartronate semialdehyde reductase; Provisional; Region: PRK15059 585055001614 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585055001615 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 585055001616 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585055001617 Na binding site [ion binding]; other site 585055001618 substrate binding site [chemical binding]; other site 585055001619 allantoinase; Provisional; Region: PRK08044 585055001620 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 585055001621 active site 585055001622 putative uracil/xanthine transporter; Provisional; Region: PRK11412 585055001623 glycerate kinase II; Provisional; Region: PRK09932 585055001624 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 585055001625 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 585055001626 Cupin domain; Region: Cupin_2; cl17218 585055001627 allantoate amidohydrolase; Region: AllC; TIGR03176 585055001628 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 585055001629 active site 585055001630 metal binding site [ion binding]; metal-binding site 585055001631 dimer interface [polypeptide binding]; other site 585055001632 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 585055001633 membrane protein FdrA; Validated; Region: PRK06091 585055001634 CoA binding domain; Region: CoA_binding; pfam02629 585055001635 CoA-ligase; Region: Ligase_CoA; pfam00549 585055001636 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585055001637 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585055001638 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585055001639 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585055001640 putative substrate binding site [chemical binding]; other site 585055001641 nucleotide binding site [chemical binding]; other site 585055001642 nucleotide binding site [chemical binding]; other site 585055001643 homodimer interface [polypeptide binding]; other site 585055001644 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 585055001645 ATP-grasp domain; Region: ATP-grasp; pfam02222 585055001646 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 585055001647 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 585055001648 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585055001649 putative active site [active] 585055001650 putative metal binding site [ion binding]; other site 585055001651 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585055001652 substrate binding site [chemical binding]; other site 585055001653 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 585055001654 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585055001655 active site 585055001656 HIGH motif; other site 585055001657 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585055001658 KMSKS motif; other site 585055001659 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 585055001660 tRNA binding surface [nucleotide binding]; other site 585055001661 anticodon binding site; other site 585055001662 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 585055001663 ribosome-associated protein; Provisional; Region: PRK11507 585055001664 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 585055001665 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 585055001666 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 585055001667 homodimer interface [polypeptide binding]; other site 585055001668 NADP binding site [chemical binding]; other site 585055001669 substrate binding site [chemical binding]; other site 585055001670 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 585055001671 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585055001672 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055001673 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055001674 outer membrane usher protein FimD; Provisional; Region: PRK15198 585055001675 PapC N-terminal domain; Region: PapC_N; pfam13954 585055001676 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055001677 PapC C-terminal domain; Region: PapC_C; pfam13953 585055001678 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 585055001679 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 585055001680 transcriptional regulator FimZ; Provisional; Region: PRK09935 585055001681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055001682 active site 585055001683 phosphorylation site [posttranslational modification] 585055001684 intermolecular recognition site; other site 585055001685 dimerization interface [polypeptide binding]; other site 585055001686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055001687 DNA binding residues [nucleotide binding] 585055001688 dimerization interface [polypeptide binding]; other site 585055001689 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585055001690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055001691 hypothetical protein; Provisional; Region: PRK09936 585055001692 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 585055001693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055001694 TPR motif; other site 585055001695 binding surface 585055001696 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 585055001697 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 585055001698 active site 585055001699 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585055001700 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 585055001701 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 585055001702 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055001703 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585055001704 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585055001705 PAAR motif; Region: PAAR_motif; pfam05488 585055001706 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055001707 RHS Repeat; Region: RHS_repeat; cl11982 585055001708 RHS Repeat; Region: RHS_repeat; pfam05593 585055001709 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 585055001710 RHS Repeat; Region: RHS_repeat; pfam05593 585055001711 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055001712 RHS Repeat; Region: RHS_repeat; pfam05593 585055001713 RHS Repeat; Region: RHS_repeat; cl11982 585055001714 RHS Repeat; Region: RHS_repeat; pfam05593 585055001715 RHS Repeat; Region: RHS_repeat; cl11982 585055001716 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 585055001717 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055001718 Uncharacterized conserved protein [Function unknown]; Region: COG5435 585055001719 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585055001720 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585055001721 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585055001722 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585055001723 sensor kinase CusS; Provisional; Region: PRK09835 585055001724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055001725 dimerization interface [polypeptide binding]; other site 585055001726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055001727 dimer interface [polypeptide binding]; other site 585055001728 phosphorylation site [posttranslational modification] 585055001729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055001730 ATP binding site [chemical binding]; other site 585055001731 Mg2+ binding site [ion binding]; other site 585055001732 G-X-G motif; other site 585055001733 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 585055001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055001735 active site 585055001736 phosphorylation site [posttranslational modification] 585055001737 intermolecular recognition site; other site 585055001738 dimerization interface [polypeptide binding]; other site 585055001739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055001740 DNA binding site [nucleotide binding] 585055001741 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 585055001742 periplasmic copper-binding protein; Provisional; Region: PRK09838 585055001743 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 585055001744 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055001745 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 585055001746 phenylalanine transporter; Provisional; Region: PRK10249 585055001747 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585055001748 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585055001749 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 585055001750 dimer interface [polypeptide binding]; other site 585055001751 FMN binding site [chemical binding]; other site 585055001752 hypothetical protein; Provisional; Region: PRK10250 585055001753 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 585055001754 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 585055001755 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 585055001756 Hok/gef family; Region: HOK_GEF; pfam01848 585055001757 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 585055001758 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 585055001759 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 585055001760 outer membrane receptor FepA; Provisional; Region: PRK13524 585055001761 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055001762 N-terminal plug; other site 585055001763 ligand-binding site [chemical binding]; other site 585055001764 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 585055001765 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 585055001766 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585055001767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 585055001768 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 585055001769 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 585055001770 acyl-activating enzyme (AAE) consensus motif; other site 585055001771 AMP binding site [chemical binding]; other site 585055001772 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585055001773 LPS O-antigen length regulator; Provisional; Region: PRK10381 585055001774 Chain length determinant protein; Region: Wzz; pfam02706 585055001775 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585055001776 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 585055001777 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585055001778 Walker A/P-loop; other site 585055001779 ATP binding site [chemical binding]; other site 585055001780 Q-loop/lid; other site 585055001781 ABC transporter signature motif; other site 585055001782 Walker B; other site 585055001783 D-loop; other site 585055001784 H-loop/switch region; other site 585055001785 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585055001786 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055001787 ABC-ATPase subunit interface; other site 585055001788 dimer interface [polypeptide binding]; other site 585055001789 putative PBP binding regions; other site 585055001790 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585055001791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055001792 ABC-ATPase subunit interface; other site 585055001793 dimer interface [polypeptide binding]; other site 585055001794 putative PBP binding regions; other site 585055001795 enterobactin exporter EntS; Provisional; Region: PRK10489 585055001796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055001797 putative substrate translocation pore; other site 585055001798 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 585055001799 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585055001800 siderophore binding site; other site 585055001801 isochorismate synthase EntC; Provisional; Region: PRK15016 585055001802 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585055001803 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 585055001804 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 585055001805 acyl-activating enzyme (AAE) consensus motif; other site 585055001806 active site 585055001807 AMP binding site [chemical binding]; other site 585055001808 substrate binding site [chemical binding]; other site 585055001809 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 585055001810 hydrophobic substrate binding pocket; other site 585055001811 Isochorismatase family; Region: Isochorismatase; pfam00857 585055001812 active site 585055001813 conserved cis-peptide bond; other site 585055001814 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 585055001815 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 585055001816 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 585055001817 putative NAD(P) binding site [chemical binding]; other site 585055001818 active site 585055001819 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585055001820 CoenzymeA binding site [chemical binding]; other site 585055001821 subunit interaction site [polypeptide binding]; other site 585055001822 PHB binding site; other site 585055001823 carbon starvation protein A; Provisional; Region: PRK15015 585055001824 Carbon starvation protein CstA; Region: CstA; pfam02554 585055001825 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585055001826 Uncharacterized small protein [Function unknown]; Region: COG2879 585055001827 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585055001828 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 585055001829 putative active site [active] 585055001830 metal binding site [ion binding]; metal-binding site 585055001831 methionine aminotransferase; Validated; Region: PRK09082 585055001832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055001833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055001834 homodimer interface [polypeptide binding]; other site 585055001835 catalytic residue [active] 585055001836 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 585055001837 ParB-like nuclease domain; Region: ParBc; pfam02195 585055001838 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 585055001839 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585055001840 Active Sites [active] 585055001841 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 585055001842 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585055001843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055001844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055001845 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 585055001846 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585055001847 dimerization domain [polypeptide binding]; other site 585055001848 dimer interface [polypeptide binding]; other site 585055001849 catalytic residues [active] 585055001850 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 585055001851 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 585055001852 dimer interface [polypeptide binding]; other site 585055001853 decamer (pentamer of dimers) interface [polypeptide binding]; other site 585055001854 catalytic triad [active] 585055001855 peroxidatic and resolving cysteines [active] 585055001856 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 585055001857 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 585055001858 catalytic residue [active] 585055001859 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 585055001860 catalytic residues [active] 585055001861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055001862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055001863 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585055001864 Ligand Binding Site [chemical binding]; other site 585055001865 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 585055001866 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585055001867 NAD binding site [chemical binding]; other site 585055001868 catalytic Zn binding site [ion binding]; other site 585055001869 structural Zn binding site [ion binding]; other site 585055001870 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 585055001871 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585055001872 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 585055001873 B1 nucleotide binding pocket [chemical binding]; other site 585055001874 B2 nucleotide binding pocket [chemical binding]; other site 585055001875 CAS motifs; other site 585055001876 active site 585055001877 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585055001878 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585055001879 transmembrane helices; other site 585055001880 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 585055001881 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 585055001882 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 585055001883 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585055001884 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 585055001885 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 585055001886 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 585055001887 putative active site [active] 585055001888 (T/H)XGH motif; other site 585055001889 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 585055001890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055001891 putative active site [active] 585055001892 heme pocket [chemical binding]; other site 585055001893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055001894 ATP binding site [chemical binding]; other site 585055001895 Mg2+ binding site [ion binding]; other site 585055001896 G-X-G motif; other site 585055001897 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 585055001898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055001899 active site 585055001900 phosphorylation site [posttranslational modification] 585055001901 intermolecular recognition site; other site 585055001902 dimerization interface [polypeptide binding]; other site 585055001903 Transcriptional regulator; Region: CitT; pfam12431 585055001904 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 585055001905 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585055001906 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 585055001907 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585055001908 DNA-binding site [nucleotide binding]; DNA binding site 585055001909 RNA-binding motif; other site 585055001910 chromosome condensation membrane protein; Provisional; Region: PRK14196 585055001911 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 585055001912 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585055001913 active site 585055001914 catalytic triad [active] 585055001915 dimer interface [polypeptide binding]; other site 585055001916 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 585055001917 lipoyl synthase; Provisional; Region: PRK05481 585055001918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055001919 FeS/SAM binding site; other site 585055001920 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585055001921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055001922 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585055001923 substrate binding pocket [chemical binding]; other site 585055001924 dimerization interface [polypeptide binding]; other site 585055001925 lipoate-protein ligase B; Provisional; Region: PRK14342 585055001926 hypothetical protein; Provisional; Region: PRK04998 585055001927 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 585055001928 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585055001929 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585055001930 rare lipoprotein A; Provisional; Region: PRK10672 585055001931 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 585055001932 Sporulation related domain; Region: SPOR; pfam05036 585055001933 cell wall shape-determining protein; Provisional; Region: PRK10794 585055001934 penicillin-binding protein 2; Provisional; Region: PRK10795 585055001935 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585055001936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585055001937 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 585055001938 ribosome-associated protein; Provisional; Region: PRK11538 585055001939 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585055001940 catalytic core [active] 585055001941 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 585055001942 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 585055001943 active site 585055001944 (T/H)XGH motif; other site 585055001945 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 585055001946 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 585055001947 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 585055001948 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 585055001949 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 585055001950 HIGH motif; other site 585055001951 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585055001952 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585055001953 active site 585055001954 KMSKS motif; other site 585055001955 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 585055001956 tRNA binding surface [nucleotide binding]; other site 585055001957 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 585055001958 hypothetical protein; Provisional; Region: PRK11032 585055001959 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 585055001960 Sel1-like repeats; Region: SEL1; smart00671 585055001961 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585055001962 Sel1-like repeats; Region: SEL1; smart00671 585055001963 Sel1-like repeats; Region: SEL1; smart00671 585055001964 Sel1-like repeats; Region: SEL1; smart00671 585055001965 Sel1-like repeats; Region: SEL1; smart00671 585055001966 Sel1-like repeats; Region: SEL1; smart00671 585055001967 Sel1-like repeats; Region: SEL1; smart00671 585055001968 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585055001969 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 585055001970 HSP70 interaction site [polypeptide binding]; other site 585055001971 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585055001972 Sel1-like repeats; Region: SEL1; smart00671 585055001973 Sel1-like repeats; Region: SEL1; smart00671 585055001974 Sel1-like repeats; Region: SEL1; smart00671 585055001975 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585055001976 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 585055001977 fragment of Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription (part 2);Evidence 7 : Gene remnant; Product type f : factor 585055001978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055001979 fragment of Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription (part 1);Evidence 7 : Gene remnant; Product type f : factor 585055001980 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585055001981 active site 585055001982 tetramer interface [polypeptide binding]; other site 585055001983 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585055001984 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585055001985 Walker A/P-loop; other site 585055001986 ATP binding site [chemical binding]; other site 585055001987 Q-loop/lid; other site 585055001988 ABC transporter signature motif; other site 585055001989 Walker B; other site 585055001990 D-loop; other site 585055001991 H-loop/switch region; other site 585055001992 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585055001993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055001994 dimer interface [polypeptide binding]; other site 585055001995 conserved gate region; other site 585055001996 putative PBP binding loops; other site 585055001997 ABC-ATPase subunit interface; other site 585055001998 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585055001999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002000 dimer interface [polypeptide binding]; other site 585055002001 conserved gate region; other site 585055002002 putative PBP binding loops; other site 585055002003 ABC-ATPase subunit interface; other site 585055002004 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 585055002005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055002006 substrate binding pocket [chemical binding]; other site 585055002007 membrane-bound complex binding site; other site 585055002008 hinge residues; other site 585055002009 fragment of membrane protein (part 1);Evidence 7 : Gene remnant 585055002010 fragment of membrane protein (part 2);Evidence 7 : Gene remnant 585055002011 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 585055002012 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 585055002013 putative active site [active] 585055002014 catalytic triad [active] 585055002015 putative dimer interface [polypeptide binding]; other site 585055002016 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 585055002017 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585055002018 Transporter associated domain; Region: CorC_HlyC; smart01091 585055002019 metal-binding heat shock protein; Provisional; Region: PRK00016 585055002020 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585055002021 PhoH-like protein; Region: PhoH; pfam02562 585055002022 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 585055002023 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585055002024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055002025 FeS/SAM binding site; other site 585055002026 TRAM domain; Region: TRAM; pfam01938 585055002027 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 585055002028 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585055002029 asparagine synthetase B; Provisional; Region: asnB; PRK09431 585055002030 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 585055002031 active site 585055002032 dimer interface [polypeptide binding]; other site 585055002033 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 585055002034 Ligand Binding Site [chemical binding]; other site 585055002035 Molecular Tunnel; other site 585055002036 UMP phosphatase; Provisional; Region: PRK10444 585055002037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002038 active site 585055002039 motif I; other site 585055002040 motif II; other site 585055002041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002042 MarR family; Region: MarR; pfam01047 585055002043 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585055002044 ROK family; Region: ROK; pfam00480 585055002045 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 585055002046 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585055002047 active site 585055002048 dimer interface [polypeptide binding]; other site 585055002049 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585055002050 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585055002051 active site 585055002052 trimer interface [polypeptide binding]; other site 585055002053 allosteric site; other site 585055002054 active site lid [active] 585055002055 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585055002056 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 585055002057 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585055002058 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055002059 active site turn [active] 585055002060 phosphorylation site [posttranslational modification] 585055002061 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585055002062 HPr interaction site; other site 585055002063 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585055002064 active site 585055002065 phosphorylation site [posttranslational modification] 585055002066 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 585055002067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585055002068 active site 585055002069 HIGH motif; other site 585055002070 nucleotide binding site [chemical binding]; other site 585055002071 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 585055002072 KMSKS motif; other site 585055002073 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 585055002074 outer membrane porin, OprD family; Region: OprD; pfam03573 585055002075 YbfN-like lipoprotein; Region: YbfN; pfam13982 585055002076 ferric uptake regulator; Provisional; Region: fur; PRK09462 585055002077 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585055002078 metal binding site 2 [ion binding]; metal-binding site 585055002079 putative DNA binding helix; other site 585055002080 metal binding site 1 [ion binding]; metal-binding site 585055002081 dimer interface [polypeptide binding]; other site 585055002082 structural Zn2+ binding site [ion binding]; other site 585055002083 flavodoxin FldA; Validated; Region: PRK09267 585055002084 LexA regulated protein; Provisional; Region: PRK11675 585055002085 acyl-CoA esterase; Provisional; Region: PRK10673 585055002086 PGAP1-like protein; Region: PGAP1; pfam07819 585055002087 replication initiation regulator SeqA; Provisional; Region: PRK11187 585055002088 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 585055002089 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 585055002090 active site 585055002091 substrate binding site [chemical binding]; other site 585055002092 metal binding site [ion binding]; metal-binding site 585055002093 putrescine transporter; Provisional; Region: potE; PRK10655 585055002094 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 585055002095 ornithine decarboxylase; Provisional; Region: PRK13578 585055002096 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585055002097 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585055002098 homodimer interface [polypeptide binding]; other site 585055002099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055002100 catalytic residue [active] 585055002101 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585055002102 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 585055002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055002104 active site 585055002105 phosphorylation site [posttranslational modification] 585055002106 intermolecular recognition site; other site 585055002107 dimerization interface [polypeptide binding]; other site 585055002108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055002109 DNA binding site [nucleotide binding] 585055002110 sensor protein KdpD; Provisional; Region: PRK10490 585055002111 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 585055002112 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 585055002113 Ligand Binding Site [chemical binding]; other site 585055002114 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 585055002115 GAF domain; Region: GAF_3; pfam13492 585055002116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055002117 dimer interface [polypeptide binding]; other site 585055002118 phosphorylation site [posttranslational modification] 585055002119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055002120 ATP binding site [chemical binding]; other site 585055002121 Mg2+ binding site [ion binding]; other site 585055002122 G-X-G motif; other site 585055002123 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 585055002124 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 585055002125 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585055002126 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 585055002127 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 585055002128 PAAR motif; Region: PAAR_motif; cl15808 585055002129 RHS Repeat; Region: RHS_repeat; pfam05593 585055002130 RHS Repeat; Region: RHS_repeat; pfam05593 585055002131 RHS Repeat; Region: RHS_repeat; cl11982 585055002132 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055002133 RHS Repeat; Region: RHS_repeat; pfam05593 585055002134 RHS Repeat; Region: RHS_repeat; pfam05593 585055002135 RHS protein; Region: RHS; pfam03527 585055002136 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055002137 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055002138 RHS protein; Region: RHS; pfam03527 585055002139 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055002140 fragment of transposase (partial);Evidence 7 : Gene remnant; Product type ph : phenotype 585055002141 fragment of transposase (partial);Evidence 7 : Gene remnant; Product type ph : phenotype 585055002142 hypothetical protein; Provisional; Region: PRK10167 585055002143 Uncharacterized conserved protein [Function unknown]; Region: COG3272 585055002144 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 585055002145 DNA photolyase; Region: DNA_photolyase; pfam00875 585055002146 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585055002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055002148 putative substrate translocation pore; other site 585055002149 POT family; Region: PTR2; pfam00854 585055002150 Uncharacterized conserved protein [Function unknown]; Region: COG0327 585055002151 metal-binding protein; Provisional; Region: PRK10799 585055002152 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 585055002153 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 585055002154 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 585055002155 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 585055002156 putative active site [active] 585055002157 endonuclease VIII; Provisional; Region: PRK10445 585055002158 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 585055002159 DNA binding site [nucleotide binding] 585055002160 catalytic residue [active] 585055002161 putative catalytic residues [active] 585055002162 H2TH interface [polypeptide binding]; other site 585055002163 intercalation triad [nucleotide binding]; other site 585055002164 substrate specificity determining residue; other site 585055002165 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585055002166 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585055002167 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 585055002168 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585055002169 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585055002170 Fimbrial protein; Region: Fimbrial; pfam00419 585055002171 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585055002172 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055002173 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055002174 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585055002175 PapC N-terminal domain; Region: PapC_N; pfam13954 585055002176 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055002177 PapC C-terminal domain; Region: PapC_C; pfam13953 585055002178 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585055002179 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 585055002180 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585055002181 dimer interface [polypeptide binding]; other site 585055002182 active site 585055002183 citrylCoA binding site [chemical binding]; other site 585055002184 NADH binding [chemical binding]; other site 585055002185 cationic pore residues; other site 585055002186 oxalacetate/citrate binding site [chemical binding]; other site 585055002187 coenzyme A binding site [chemical binding]; other site 585055002188 catalytic triad [active] 585055002189 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 585055002190 Iron-sulfur protein interface; other site 585055002191 proximal quinone binding site [chemical binding]; other site 585055002192 SdhD (CybS) interface [polypeptide binding]; other site 585055002193 proximal heme binding site [chemical binding]; other site 585055002194 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 585055002195 SdhC subunit interface [polypeptide binding]; other site 585055002196 proximal heme binding site [chemical binding]; other site 585055002197 cardiolipin binding site; other site 585055002198 Iron-sulfur protein interface; other site 585055002199 proximal quinone binding site [chemical binding]; other site 585055002200 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 585055002201 L-aspartate oxidase; Provisional; Region: PRK06175 585055002202 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585055002203 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 585055002204 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585055002205 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 585055002206 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 585055002207 TPP-binding site [chemical binding]; other site 585055002208 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 585055002209 dimer interface [polypeptide binding]; other site 585055002210 PYR/PP interface [polypeptide binding]; other site 585055002211 TPP binding site [chemical binding]; other site 585055002212 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 585055002213 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585055002214 E3 interaction surface; other site 585055002215 lipoyl attachment site [posttranslational modification]; other site 585055002216 e3 binding domain; Region: E3_binding; pfam02817 585055002217 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585055002218 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 585055002219 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 585055002220 CoA-ligase; Region: Ligase_CoA; pfam00549 585055002221 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 585055002222 CoA binding domain; Region: CoA_binding; smart00881 585055002223 CoA-ligase; Region: Ligase_CoA; pfam00549 585055002224 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 585055002225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055002226 DNA-binding site [nucleotide binding]; DNA binding site 585055002227 UTRA domain; Region: UTRA; pfam07702 585055002228 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 585055002229 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055002230 active site 585055002231 phosphorylation site [posttranslational modification] 585055002232 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585055002233 active site 585055002234 P-loop; other site 585055002235 phosphorylation site [posttranslational modification] 585055002236 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585055002237 alpha-mannosidase; Provisional; Region: PRK09819 585055002238 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 585055002239 active site 585055002240 metal binding site [ion binding]; metal-binding site 585055002241 catalytic site [active] 585055002242 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 585055002243 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585055002244 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 585055002245 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 585055002246 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 585055002247 hypothetical protein; Provisional; Region: PRK10588 585055002248 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585055002249 active site 585055002250 colicin uptake protein TolQ; Provisional; Region: PRK10801 585055002251 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585055002252 colicin uptake protein TolR; Provisional; Region: PRK11024 585055002253 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585055002254 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585055002255 TolA C-terminal; Region: TolA; pfam06519 585055002256 translocation protein TolB; Provisional; Region: tolB; PRK03629 585055002257 TolB amino-terminal domain; Region: TolB_N; pfam04052 585055002258 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585055002259 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585055002260 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585055002261 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 585055002262 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585055002263 ligand binding site [chemical binding]; other site 585055002264 tol-pal system protein YbgF; Provisional; Region: PRK10803 585055002265 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585055002266 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585055002267 quinolinate synthetase; Provisional; Region: PRK09375 585055002268 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 585055002269 zinc transporter ZitB; Provisional; Region: PRK03557 585055002270 YbgS-like protein; Region: YbgS; pfam13985 585055002271 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 585055002272 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585055002273 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585055002274 catalytic core [active] 585055002275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585055002276 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 585055002277 active site 585055002278 catalytic residues [active] 585055002279 galactokinase; Provisional; Region: PRK05101 585055002280 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 585055002281 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585055002282 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 585055002283 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 585055002284 dimer interface [polypeptide binding]; other site 585055002285 active site 585055002286 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 585055002287 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 585055002288 NAD binding site [chemical binding]; other site 585055002289 homodimer interface [polypeptide binding]; other site 585055002290 active site 585055002291 substrate binding site [chemical binding]; other site 585055002292 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 585055002293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 585055002294 Walker A/P-loop; other site 585055002295 ATP binding site [chemical binding]; other site 585055002296 Q-loop/lid; other site 585055002297 ABC transporter signature motif; other site 585055002298 Walker B; other site 585055002299 D-loop; other site 585055002300 H-loop/switch region; other site 585055002301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055002302 Walker A/P-loop; other site 585055002303 ATP binding site [chemical binding]; other site 585055002304 Q-loop/lid; other site 585055002305 ABC transporter signature motif; other site 585055002306 Walker B; other site 585055002307 D-loop; other site 585055002308 H-loop/switch region; other site 585055002309 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 585055002310 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 585055002311 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585055002312 TOBE domain; Region: TOBE; pfam03459 585055002313 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 585055002314 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 585055002315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055002316 substrate binding pocket [chemical binding]; other site 585055002317 membrane-bound complex binding site; other site 585055002318 hinge residues; other site 585055002319 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585055002320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002321 putative PBP binding loops; other site 585055002322 ABC-ATPase subunit interface; other site 585055002323 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 585055002324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055002325 Walker A/P-loop; other site 585055002326 ATP binding site [chemical binding]; other site 585055002327 Q-loop/lid; other site 585055002328 ABC transporter signature motif; other site 585055002329 Walker B; other site 585055002330 D-loop; other site 585055002331 H-loop/switch region; other site 585055002332 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585055002333 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 585055002334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002335 motif II; other site 585055002336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002337 6-phosphogluconolactonase; Provisional; Region: PRK11028 585055002338 fragment of DNA-binding transcriptional regulator (partial);Evidence 7 : Gene remnant; Product type pr : regulator 585055002339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055002340 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055002341 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055002342 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055002343 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055002344 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585055002345 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585055002346 transmembrane helices; other site 585055002347 putative hydratase; Provisional; Region: PRK11413 585055002348 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 585055002349 substrate binding site [chemical binding]; other site 585055002350 ligand binding site [chemical binding]; other site 585055002351 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 585055002352 substrate binding site [chemical binding]; other site 585055002353 acyl-CoA thioesterase; Provisional; Region: PRK10531 585055002354 putative pectinesterase; Region: PLN02432; cl01911 585055002355 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585055002356 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 585055002357 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 585055002358 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585055002359 dimer interface [polypeptide binding]; other site 585055002360 active site 585055002361 Int/Topo IB signature motif; other site 585055002362 DksA-like zinc finger domain containing protein; Region: PHA00080 585055002363 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 585055002364 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 585055002365 phage recombination protein Bet; Region: bet_lambda; TIGR01913 585055002366 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 585055002367 fragment of prophage Kil protein (modular protein) (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055002368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055002369 non-specific DNA binding site [nucleotide binding]; other site 585055002370 salt bridge; other site 585055002371 Predicted transcriptional regulator [Transcription]; Region: COG2932 585055002372 sequence-specific DNA binding site [nucleotide binding]; other site 585055002373 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585055002374 Catalytic site [active] 585055002375 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 585055002376 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585055002377 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 585055002378 Replication protein P; Region: Phage_lambda_P; pfam06992 585055002379 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 585055002380 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 585055002381 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 585055002382 catalytic residues [active] 585055002383 catalytic nucleophile [active] 585055002384 Recombinase; Region: Recombinase; pfam07508 585055002385 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 585055002386 fragment of conserved hypothetical protein from bacteriophage origin (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055002387 hypothetical protein; Provisional; Region: PRK09741 585055002388 prophage protein NinE; Provisional; Region: PRK09689 585055002389 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 585055002390 fragment of endonuclease RUS; DLP12 prophage (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055002391 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585055002392 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585055002393 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585055002394 trimer interface [polypeptide binding]; other site 585055002395 eyelet of channel; other site 585055002396 Lysis protein S; Region: Lysis_S; pfam04971 585055002397 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585055002398 catalytic residues [active] 585055002399 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585055002400 KilA-N domain; Region: KilA-N; pfam04383 585055002401 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585055002402 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585055002403 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585055002404 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 585055002405 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 585055002406 fragment of terminase large subunit (DNA packaging protein A) from bacteriophage origin (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055002407 gpW; Region: gpW; pfam02831 585055002408 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585055002409 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585055002410 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585055002411 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585055002412 tandem repeat interface [polypeptide binding]; other site 585055002413 oligomer interface [polypeptide binding]; other site 585055002414 active site residues [active] 585055002415 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585055002416 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585055002417 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585055002418 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585055002419 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585055002420 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585055002421 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585055002422 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585055002423 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585055002424 Minor tail protein T; Region: Phage_tail_T; pfam06223 585055002425 Phage-related minor tail protein [Function unknown]; Region: COG5281 585055002426 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585055002427 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585055002428 Phage-related protein [Function unknown]; Region: COG4718 585055002429 Phage-related protein [Function unknown]; Region: gp18; COG4672 585055002430 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585055002431 MPN+ (JAMM) motif; other site 585055002432 Zinc-binding site [ion binding]; other site 585055002433 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585055002434 NlpC/P60 family; Region: NLPC_P60; cl17555 585055002435 Phage-related protein, tail component [Function unknown]; Region: COG4723 585055002436 Phage-related protein, tail component [Function unknown]; Region: COG4733 585055002437 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585055002438 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585055002439 Fibronectin type III protein; Region: DUF3672; pfam12421 585055002440 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585055002441 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585055002442 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585055002443 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585055002444 Phage Tail Collar Domain; Region: Collar; pfam07484 585055002445 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585055002446 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055002447 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055002448 metal binding site [ion binding]; metal-binding site 585055002449 active site 585055002450 I-site; other site 585055002451 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585055002452 substrate binding site [chemical binding]; other site 585055002453 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 585055002454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585055002455 inhibitor-cofactor binding pocket; inhibition site 585055002456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055002457 catalytic residue [active] 585055002458 biotin synthase; Provisional; Region: PRK15108 585055002459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055002460 FeS/SAM binding site; other site 585055002461 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 585055002462 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585055002463 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585055002464 substrate-cofactor binding pocket; other site 585055002465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055002466 catalytic residue [active] 585055002467 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 585055002468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055002469 S-adenosylmethionine binding site [chemical binding]; other site 585055002470 AAA domain; Region: AAA_26; pfam13500 585055002471 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585055002472 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 585055002473 ADP binding site [chemical binding]; other site 585055002474 excinuclease ABC subunit B; Provisional; Region: PRK05298 585055002475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055002476 ATP binding site [chemical binding]; other site 585055002477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055002478 nucleotide binding region [chemical binding]; other site 585055002479 ATP-binding site [chemical binding]; other site 585055002480 Ultra-violet resistance protein B; Region: UvrB; pfam12344 585055002481 UvrB/uvrC motif; Region: UVR; pfam02151 585055002482 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 585055002483 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 585055002484 putative substrate binding pocket [chemical binding]; other site 585055002485 dimer interface [polypeptide binding]; other site 585055002486 phosphate binding site [ion binding]; other site 585055002487 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 585055002488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055002489 FeS/SAM binding site; other site 585055002490 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 585055002491 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585055002492 MPT binding site; other site 585055002493 trimer interface [polypeptide binding]; other site 585055002494 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 585055002495 trimer interface [polypeptide binding]; other site 585055002496 dimer interface [polypeptide binding]; other site 585055002497 putative active site [active] 585055002498 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 585055002499 MoaE interaction surface [polypeptide binding]; other site 585055002500 MoeB interaction surface [polypeptide binding]; other site 585055002501 thiocarboxylated glycine; other site 585055002502 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 585055002503 MoaE homodimer interface [polypeptide binding]; other site 585055002504 MoaD interaction [polypeptide binding]; other site 585055002505 active site residues [active] 585055002506 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585055002507 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585055002508 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585055002509 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 585055002510 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585055002511 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585055002512 Predicted integral membrane protein [Function unknown]; Region: COG0392 585055002513 cardiolipin synthase 2; Provisional; Region: PRK11263 585055002514 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 585055002515 putative active site [active] 585055002516 catalytic site [active] 585055002517 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 585055002518 putative active site [active] 585055002519 catalytic site [active] 585055002520 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 585055002521 putative catalytic site [active] 585055002522 putative metal binding site [ion binding]; other site 585055002523 putative phosphate binding site [ion binding]; other site 585055002524 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 585055002525 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585055002526 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585055002527 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585055002528 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585055002529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585055002530 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585055002531 Walker A/P-loop; other site 585055002532 ATP binding site [chemical binding]; other site 585055002533 Q-loop/lid; other site 585055002534 ABC transporter signature motif; other site 585055002535 Walker B; other site 585055002536 D-loop; other site 585055002537 H-loop/switch region; other site 585055002538 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 585055002539 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585055002540 Walker A/P-loop; other site 585055002541 ATP binding site [chemical binding]; other site 585055002542 Q-loop/lid; other site 585055002543 ABC transporter signature motif; other site 585055002544 Walker B; other site 585055002545 D-loop; other site 585055002546 H-loop/switch region; other site 585055002547 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 585055002548 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055002549 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055002550 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 585055002551 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 585055002552 helicase 45; Provisional; Region: PTZ00424 585055002553 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585055002554 ATP binding site [chemical binding]; other site 585055002555 Mg++ binding site [ion binding]; other site 585055002556 motif III; other site 585055002557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055002558 nucleotide binding region [chemical binding]; other site 585055002559 ATP-binding site [chemical binding]; other site 585055002560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 585055002561 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 585055002562 DEAD_2; Region: DEAD_2; pfam06733 585055002563 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585055002564 glycosyl transferase family protein; Provisional; Region: PRK08136 585055002565 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585055002566 putative dehydrogenase; Provisional; Region: PRK10098 585055002567 hypothetical protein; Provisional; Region: PRK10259 585055002568 hypothetical protein; Provisional; Region: PRK11019 585055002569 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 585055002570 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 585055002571 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055002572 N-terminal plug; other site 585055002573 ligand-binding site [chemical binding]; other site 585055002574 hypothetical protein; Provisional; Region: PRK10259 585055002575 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 585055002576 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 585055002577 putative mechanosensitive channel protein; Provisional; Region: PRK11465 585055002578 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585055002579 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 585055002580 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585055002581 Walker A/P-loop; other site 585055002582 ATP binding site [chemical binding]; other site 585055002583 Q-loop/lid; other site 585055002584 ABC transporter signature motif; other site 585055002585 Walker B; other site 585055002586 D-loop; other site 585055002587 H-loop/switch region; other site 585055002588 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585055002589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002590 dimer interface [polypeptide binding]; other site 585055002591 conserved gate region; other site 585055002592 putative PBP binding loops; other site 585055002593 ABC-ATPase subunit interface; other site 585055002594 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 585055002595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055002596 substrate binding pocket [chemical binding]; other site 585055002597 membrane-bound complex binding site; other site 585055002598 hinge residues; other site 585055002599 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 585055002600 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 585055002601 dimerization interface [polypeptide binding]; other site 585055002602 DPS ferroxidase diiron center [ion binding]; other site 585055002603 ion pore; other site 585055002604 threonine and homoserine efflux system; Provisional; Region: PRK10532 585055002605 EamA-like transporter family; Region: EamA; pfam00892 585055002606 outer membrane protein X; Provisional; Region: ompX; PRK09408 585055002607 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585055002608 Sulfatase; Region: Sulfatase; pfam00884 585055002609 manganese transport regulator MntR; Provisional; Region: PRK11050 585055002610 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585055002611 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 585055002612 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585055002613 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 585055002614 transmembrane helices; other site 585055002615 L,D-transpeptidase; Provisional; Region: PRK10260 585055002616 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585055002617 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 585055002618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055002619 Walker A/P-loop; other site 585055002620 ATP binding site [chemical binding]; other site 585055002621 Q-loop/lid; other site 585055002622 ABC transporter signature motif; other site 585055002623 Walker B; other site 585055002624 D-loop; other site 585055002625 H-loop/switch region; other site 585055002626 ABC transporter; Region: ABC_tran_2; pfam12848 585055002627 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585055002628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055002629 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055002630 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055002631 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 585055002632 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 585055002633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002634 active site 585055002635 motif I; other site 585055002636 motif II; other site 585055002637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002638 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 585055002639 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585055002640 dimer interface [polypeptide binding]; other site 585055002641 active site 585055002642 glycine loop; other site 585055002643 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 585055002644 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585055002645 active site 585055002646 intersubunit interactions; other site 585055002647 catalytic residue [active] 585055002648 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 585055002649 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585055002650 ATP binding site [chemical binding]; other site 585055002651 substrate interface [chemical binding]; other site 585055002652 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 585055002653 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 585055002654 dimer interface [polypeptide binding]; other site 585055002655 putative functional site; other site 585055002656 putative MPT binding site; other site 585055002657 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 585055002658 catalytic nucleophile [active] 585055002659 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 585055002660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055002661 Walker A/P-loop; other site 585055002662 ATP binding site [chemical binding]; other site 585055002663 Q-loop/lid; other site 585055002664 ABC transporter signature motif; other site 585055002665 Walker B; other site 585055002666 D-loop; other site 585055002667 H-loop/switch region; other site 585055002668 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585055002669 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055002670 Walker A/P-loop; other site 585055002671 ATP binding site [chemical binding]; other site 585055002672 Q-loop/lid; other site 585055002673 ABC transporter signature motif; other site 585055002674 Walker B; other site 585055002675 D-loop; other site 585055002676 H-loop/switch region; other site 585055002677 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585055002678 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 585055002679 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 585055002680 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 585055002681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002682 dimer interface [polypeptide binding]; other site 585055002683 conserved gate region; other site 585055002684 putative PBP binding loops; other site 585055002685 ABC-ATPase subunit interface; other site 585055002686 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 585055002687 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585055002688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002689 dimer interface [polypeptide binding]; other site 585055002690 conserved gate region; other site 585055002691 putative PBP binding loops; other site 585055002692 ABC-ATPase subunit interface; other site 585055002693 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055002694 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055002695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055002696 metal binding site [ion binding]; metal-binding site 585055002697 active site 585055002698 I-site; other site 585055002699 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 585055002700 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585055002701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055002702 FeS/SAM binding site; other site 585055002703 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 585055002704 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 585055002705 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 585055002706 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585055002707 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 585055002708 putative C-terminal domain interface [polypeptide binding]; other site 585055002709 putative GSH binding site (G-site) [chemical binding]; other site 585055002710 putative dimer interface [polypeptide binding]; other site 585055002711 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 585055002712 N-terminal domain interface [polypeptide binding]; other site 585055002713 dimer interface [polypeptide binding]; other site 585055002714 substrate binding pocket (H-site) [chemical binding]; other site 585055002715 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 585055002716 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585055002717 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585055002718 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 585055002719 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585055002720 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055002721 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 585055002722 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585055002723 active site 585055002724 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 585055002725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055002726 putative substrate translocation pore; other site 585055002727 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 585055002728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002729 active site 585055002730 motif I; other site 585055002731 motif II; other site 585055002732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055002733 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585055002734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055002735 putative substrate translocation pore; other site 585055002736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055002737 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 585055002738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055002739 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585055002740 putative transporter; Provisional; Region: PRK04972 585055002741 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585055002742 TrkA-C domain; Region: TrkA_C; pfam02080 585055002743 TrkA-C domain; Region: TrkA_C; pfam02080 585055002744 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585055002745 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 585055002746 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 585055002747 GSH binding site [chemical binding]; other site 585055002748 catalytic residues [active] 585055002749 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 585055002750 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 585055002751 dimer interface [polypeptide binding]; other site 585055002752 FMN binding site [chemical binding]; other site 585055002753 NADPH bind site [chemical binding]; other site 585055002754 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 585055002755 RimK-like ATP-grasp domain; Region: RimK; pfam08443 585055002756 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 585055002757 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 585055002758 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 585055002759 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 585055002760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055002761 Walker A/P-loop; other site 585055002762 ATP binding site [chemical binding]; other site 585055002763 Q-loop/lid; other site 585055002764 ABC transporter signature motif; other site 585055002765 Walker B; other site 585055002766 D-loop; other site 585055002767 H-loop/switch region; other site 585055002768 TOBE domain; Region: TOBE_2; pfam08402 585055002769 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585055002770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002771 dimer interface [polypeptide binding]; other site 585055002772 conserved gate region; other site 585055002773 putative PBP binding loops; other site 585055002774 ABC-ATPase subunit interface; other site 585055002775 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585055002776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002777 dimer interface [polypeptide binding]; other site 585055002778 conserved gate region; other site 585055002779 putative PBP binding loops; other site 585055002780 ABC-ATPase subunit interface; other site 585055002781 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 585055002782 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 585055002783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055002784 S-adenosylmethionine binding site [chemical binding]; other site 585055002785 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585055002786 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055002787 substrate binding pocket [chemical binding]; other site 585055002788 membrane-bound complex binding site; other site 585055002789 hinge residues; other site 585055002790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002791 dimer interface [polypeptide binding]; other site 585055002792 conserved gate region; other site 585055002793 putative PBP binding loops; other site 585055002794 ABC-ATPase subunit interface; other site 585055002795 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585055002796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055002797 dimer interface [polypeptide binding]; other site 585055002798 conserved gate region; other site 585055002799 putative PBP binding loops; other site 585055002800 ABC-ATPase subunit interface; other site 585055002801 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585055002802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055002803 substrate binding pocket [chemical binding]; other site 585055002804 membrane-bound complex binding site; other site 585055002805 hinge residues; other site 585055002806 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 585055002807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055002808 Walker A/P-loop; other site 585055002809 ATP binding site [chemical binding]; other site 585055002810 Q-loop/lid; other site 585055002811 ABC transporter signature motif; other site 585055002812 Walker B; other site 585055002813 D-loop; other site 585055002814 H-loop/switch region; other site 585055002815 putative lipoprotein; Provisional; Region: PRK10533 585055002816 hypothetical protein; Provisional; Region: PRK02877 585055002817 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585055002818 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585055002819 amidase catalytic site [active] 585055002820 Zn binding residues [ion binding]; other site 585055002821 substrate binding site [chemical binding]; other site 585055002822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585055002823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585055002824 NAD(P) binding site [chemical binding]; other site 585055002825 active site 585055002826 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585055002827 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 585055002828 putative NAD(P) binding site [chemical binding]; other site 585055002829 putative active site [active] 585055002830 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 585055002831 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 585055002832 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 585055002833 tetramer interface [polypeptide binding]; other site 585055002834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055002835 catalytic residue [active] 585055002836 pyruvate dehydrogenase; Provisional; Region: PRK09124 585055002837 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 585055002838 PYR/PP interface [polypeptide binding]; other site 585055002839 dimer interface [polypeptide binding]; other site 585055002840 tetramer interface [polypeptide binding]; other site 585055002841 TPP binding site [chemical binding]; other site 585055002842 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585055002843 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 585055002844 TPP-binding site [chemical binding]; other site 585055002845 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 585055002846 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 585055002847 FAD binding pocket [chemical binding]; other site 585055002848 FAD binding motif [chemical binding]; other site 585055002849 phosphate binding motif [ion binding]; other site 585055002850 beta-alpha-beta structure motif; other site 585055002851 NAD binding pocket [chemical binding]; other site 585055002852 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055002853 catalytic loop [active] 585055002854 iron binding site [ion binding]; other site 585055002855 hybrid cluster protein; Provisional; Region: PRK05290 585055002856 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055002857 ACS interaction site; other site 585055002858 CODH interaction site; other site 585055002859 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 585055002860 hybrid metal cluster; other site 585055002861 Predicted membrane protein [Function unknown]; Region: COG2431 585055002862 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585055002863 amphipathic channel; other site 585055002864 Asn-Pro-Ala signature motifs; other site 585055002865 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 585055002866 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 585055002867 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 585055002868 putative active site [active] 585055002869 putative metal-binding site [ion binding]; other site 585055002870 Protein of unknown function (DUF535); Region: DUF535; pfam04393 585055002871 macrolide transporter subunit MacA; Provisional; Region: PRK11578 585055002872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055002873 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055002874 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 585055002875 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585055002876 Walker A/P-loop; other site 585055002877 ATP binding site [chemical binding]; other site 585055002878 Q-loop/lid; other site 585055002879 ABC transporter signature motif; other site 585055002880 Walker B; other site 585055002881 D-loop; other site 585055002882 H-loop/switch region; other site 585055002883 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585055002884 FtsX-like permease family; Region: FtsX; pfam02687 585055002885 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585055002886 DNA-binding site [nucleotide binding]; DNA binding site 585055002887 RNA-binding motif; other site 585055002888 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 585055002889 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 585055002890 Clp amino terminal domain; Region: Clp_N; pfam02861 585055002891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055002892 Walker A motif; other site 585055002893 ATP binding site [chemical binding]; other site 585055002894 Walker B motif; other site 585055002895 arginine finger; other site 585055002896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055002897 Walker A motif; other site 585055002898 ATP binding site [chemical binding]; other site 585055002899 Walker B motif; other site 585055002900 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585055002901 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 585055002902 rRNA binding site [nucleotide binding]; other site 585055002903 predicted 30S ribosome binding site; other site 585055002904 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 585055002905 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 585055002906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585055002907 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 585055002908 Walker A/P-loop; other site 585055002909 ATP binding site [chemical binding]; other site 585055002910 Q-loop/lid; other site 585055002911 ABC transporter signature motif; other site 585055002912 Walker B; other site 585055002913 D-loop; other site 585055002914 H-loop/switch region; other site 585055002915 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 585055002916 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585055002917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055002918 Walker A/P-loop; other site 585055002919 ATP binding site [chemical binding]; other site 585055002920 Q-loop/lid; other site 585055002921 ABC transporter signature motif; other site 585055002922 Walker B; other site 585055002923 D-loop; other site 585055002924 H-loop/switch region; other site 585055002925 thioredoxin reductase; Provisional; Region: PRK10262 585055002926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055002927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055002928 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 585055002929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055002930 putative DNA binding site [nucleotide binding]; other site 585055002931 putative Zn2+ binding site [ion binding]; other site 585055002932 AsnC family; Region: AsnC_trans_reg; pfam01037 585055002933 DNA translocase FtsK; Provisional; Region: PRK10263 585055002934 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 585055002935 DNA translocase FtsK; Provisional; Region: PRK10263 585055002936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 585055002937 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 585055002938 periplasmic chaperone LolA; Region: lolA; TIGR00547 585055002939 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 585055002940 recombination factor protein RarA; Reviewed; Region: PRK13342 585055002941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055002942 Walker A motif; other site 585055002943 ATP binding site [chemical binding]; other site 585055002944 Walker B motif; other site 585055002945 arginine finger; other site 585055002946 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 585055002947 seryl-tRNA synthetase; Provisional; Region: PRK05431 585055002948 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 585055002949 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 585055002950 dimer interface [polypeptide binding]; other site 585055002951 active site 585055002952 motif 1; other site 585055002953 motif 2; other site 585055002954 motif 3; other site 585055002955 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 585055002956 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585055002957 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585055002958 putative [Fe4-S4] binding site [ion binding]; other site 585055002959 putative molybdopterin cofactor binding site [chemical binding]; other site 585055002960 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585055002961 putative molybdopterin cofactor binding site; other site 585055002962 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585055002963 4Fe-4S binding domain; Region: Fer4; pfam00037 585055002964 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585055002965 Isochorismatase family; Region: Isochorismatase; pfam00857 585055002966 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 585055002967 catalytic triad [active] 585055002968 dimer interface [polypeptide binding]; other site 585055002969 conserved cis-peptide bond; other site 585055002970 putative MFS family transporter protein; Provisional; Region: PRK03633 585055002971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055002972 putative substrate translocation pore; other site 585055002973 Amino acid permease; Region: AA_permease_2; pfam13520 585055002974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055002975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055002976 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585055002977 putative effector binding pocket; other site 585055002978 putative dimerization interface [polypeptide binding]; other site 585055002979 hypothetical protein; Provisional; Region: PRK09739 585055002980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585055002981 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 585055002982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055002983 FeS/SAM binding site; other site 585055002984 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585055002985 Pyruvate formate lyase 1; Region: PFL1; cd01678 585055002986 coenzyme A binding site [chemical binding]; other site 585055002987 active site 585055002988 catalytic residues [active] 585055002989 glycine loop; other site 585055002990 formate transporter; Provisional; Region: PRK10805 585055002991 uncharacterized domain; Region: TIGR00702 585055002992 YcaO-like family; Region: YcaO; pfam02624 585055002993 Predicted membrane protein [Function unknown]; Region: COG2323 585055002994 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 585055002995 homodimer interface [polypeptide binding]; other site 585055002996 substrate-cofactor binding pocket; other site 585055002997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055002998 catalytic residue [active] 585055002999 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 585055003000 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 585055003001 hinge; other site 585055003002 active site 585055003003 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585055003004 cytidylate kinase; Provisional; Region: cmk; PRK00023 585055003005 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 585055003006 CMP-binding site; other site 585055003007 The sites determining sugar specificity; other site 585055003008 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 585055003009 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 585055003010 RNA binding site [nucleotide binding]; other site 585055003011 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 585055003012 RNA binding site [nucleotide binding]; other site 585055003013 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 585055003014 RNA binding site [nucleotide binding]; other site 585055003015 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 585055003016 RNA binding site [nucleotide binding]; other site 585055003017 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 585055003018 RNA binding site [nucleotide binding]; other site 585055003019 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585055003020 IHF dimer interface [polypeptide binding]; other site 585055003021 IHF - DNA interface [nucleotide binding]; other site 585055003022 ComEC family competence protein; Provisional; Region: PRK11539 585055003023 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 585055003024 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 585055003025 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 585055003026 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 585055003027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585055003028 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 585055003029 Walker A/P-loop; other site 585055003030 ATP binding site [chemical binding]; other site 585055003031 Q-loop/lid; other site 585055003032 ABC transporter signature motif; other site 585055003033 Walker B; other site 585055003034 D-loop; other site 585055003035 H-loop/switch region; other site 585055003036 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 585055003037 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 585055003038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 585055003039 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 585055003040 hypothetical protein; Provisional; Region: PRK11827 585055003041 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 585055003042 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 585055003043 Ligand binding site; other site 585055003044 oligomer interface; other site 585055003045 hypothetical protein; Provisional; Region: PRK10593 585055003046 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585055003047 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585055003048 putative active site [active] 585055003049 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585055003050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055003051 S-adenosylmethionine binding site [chemical binding]; other site 585055003052 condesin subunit F; Provisional; Region: PRK05260 585055003053 condesin subunit E; Provisional; Region: PRK05256 585055003054 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 585055003055 MukB N-terminal; Region: MukB; pfam04310 585055003056 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 585055003057 murein L,D-transpeptidase; Provisional; Region: PRK10594 585055003058 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 585055003059 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585055003060 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585055003061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 585055003062 Peptidase M15; Region: Peptidase_M15_3; cl01194 585055003063 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 585055003064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055003065 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055003066 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055003067 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585055003068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055003069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055003070 homodimer interface [polypeptide binding]; other site 585055003071 catalytic residue [active] 585055003072 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585055003073 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585055003074 trimer interface [polypeptide binding]; other site 585055003075 eyelet of channel; other site 585055003076 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 585055003077 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 585055003078 putative dimer interface [polypeptide binding]; other site 585055003079 putative anticodon binding site; other site 585055003080 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 585055003081 homodimer interface [polypeptide binding]; other site 585055003082 motif 1; other site 585055003083 motif 2; other site 585055003084 active site 585055003085 motif 3; other site 585055003086 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 585055003087 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 585055003088 active site 585055003089 aminopeptidase N; Provisional; Region: pepN; PRK14015 585055003090 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 585055003091 active site 585055003092 Zn binding site [ion binding]; other site 585055003093 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 585055003094 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585055003095 Walker A/P-loop; other site 585055003096 ATP binding site [chemical binding]; other site 585055003097 Q-loop/lid; other site 585055003098 ABC transporter signature motif; other site 585055003099 Walker B; other site 585055003100 D-loop; other site 585055003101 H-loop/switch region; other site 585055003102 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585055003103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055003104 dimer interface [polypeptide binding]; other site 585055003105 conserved gate region; other site 585055003106 putative PBP binding loops; other site 585055003107 ABC-ATPase subunit interface; other site 585055003108 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 585055003109 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585055003110 active site 585055003111 dimer interface [polypeptide binding]; other site 585055003112 non-prolyl cis peptide bond; other site 585055003113 insertion regions; other site 585055003114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055003115 substrate binding pocket [chemical binding]; other site 585055003116 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 585055003117 membrane-bound complex binding site; other site 585055003118 hinge residues; other site 585055003119 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 585055003120 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585055003121 Fimbrial protein; Region: Fimbrial; cl01416 585055003122 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585055003123 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055003124 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055003125 outer membrane usher protein; Provisional; Region: PRK15193 585055003126 PapC N-terminal domain; Region: PapC_N; pfam13954 585055003127 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055003128 PapC C-terminal domain; Region: PapC_C; pfam13953 585055003129 Fimbrial protein; Region: Fimbrial; cl01416 585055003130 Fimbrial protein; Region: Fimbrial; cl01416 585055003131 Fimbrial protein; Region: Fimbrial; cl01416 585055003132 putativi pili assembly chaperone; Provisional; Region: PRK11385 585055003133 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055003134 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055003135 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 585055003136 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 585055003137 quinone interaction residues [chemical binding]; other site 585055003138 active site 585055003139 catalytic residues [active] 585055003140 FMN binding site [chemical binding]; other site 585055003141 substrate binding site [chemical binding]; other site 585055003142 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 585055003143 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 585055003144 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 585055003145 MOSC domain; Region: MOSC; pfam03473 585055003146 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055003147 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585055003148 catalytic loop [active] 585055003149 iron binding site [ion binding]; other site 585055003150 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 585055003151 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 585055003152 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 585055003153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055003154 S-adenosylmethionine binding site [chemical binding]; other site 585055003155 ABC transporter ATPase component; Reviewed; Region: PRK11147 585055003156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055003157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055003158 Walker A/P-loop; other site 585055003159 Walker A/P-loop; other site 585055003160 ATP binding site [chemical binding]; other site 585055003161 ATP binding site [chemical binding]; other site 585055003162 Q-loop/lid; other site 585055003163 Q-loop/lid; other site 585055003164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585055003165 ABC transporter signature motif; other site 585055003166 Walker B; other site 585055003167 D-loop; other site 585055003168 ABC transporter; Region: ABC_tran_2; pfam12848 585055003169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585055003170 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 585055003171 Paraquat-inducible protein A; Region: PqiA; pfam04403 585055003172 Paraquat-inducible protein A; Region: PqiA; pfam04403 585055003173 paraquat-inducible protein B; Provisional; Region: PRK10807 585055003174 mce related protein; Region: MCE; pfam02470 585055003175 mce related protein; Region: MCE; pfam02470 585055003176 mce related protein; Region: MCE; pfam02470 585055003177 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 585055003178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 585055003179 Protein of unknown function (DUF330); Region: DUF330; pfam03886 585055003180 ribosome modulation factor; Provisional; Region: PRK14563 585055003181 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 585055003182 active site 1 [active] 585055003183 dimer interface [polypeptide binding]; other site 585055003184 active site 2 [active] 585055003185 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 585055003186 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585055003187 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 585055003188 outer membrane protein A; Reviewed; Region: PRK10808 585055003189 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 585055003190 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585055003191 ligand binding site [chemical binding]; other site 585055003192 cell division inhibitor SulA; Region: sula; TIGR00623 585055003193 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 585055003194 TfoX C-terminal domain; Region: TfoX_C; pfam04994 585055003195 TIGR01666 family membrane protein; Region: YCCS 585055003196 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585055003197 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585055003198 Predicted membrane protein [Function unknown]; Region: COG3304 585055003199 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585055003200 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585055003201 DNA helicase IV; Provisional; Region: helD; PRK11054 585055003202 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 585055003203 Part of AAA domain; Region: AAA_19; pfam13245 585055003204 Family description; Region: UvrD_C_2; pfam13538 585055003205 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 585055003206 active site 585055003207 dimer interfaces [polypeptide binding]; other site 585055003208 catalytic residues [active] 585055003209 hypothetical protein; Provisional; Region: PRK03641 585055003210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 585055003211 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 585055003212 heat shock protein HspQ; Provisional; Region: PRK14129 585055003213 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 585055003214 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 585055003215 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 585055003216 putative RNA binding site [nucleotide binding]; other site 585055003217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055003218 S-adenosylmethionine binding site [chemical binding]; other site 585055003219 acylphosphatase; Provisional; Region: PRK14439 585055003220 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 585055003221 sulfur transfer protein TusE; Provisional; Region: PRK11508 585055003222 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585055003223 YccA-like proteins; Region: YccA_like; cd10433 585055003224 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585055003225 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585055003226 dimer interface [polypeptide binding]; other site 585055003227 active site 585055003228 Int/Topo IB signature motif; other site 585055003229 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 585055003230 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585055003231 active site 585055003232 substrate binding site [chemical binding]; other site 585055003233 catalytic site [active] 585055003234 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585055003235 DicB protein; Region: DicB; pfam05358 585055003236 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585055003237 transcriptional repressor DicA; Reviewed; Region: PRK09706 585055003238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055003239 sequence-specific DNA binding site [nucleotide binding]; other site 585055003240 salt bridge; other site 585055003241 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585055003242 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585055003243 Pyocin large subunit [General function prediction only]; Region: COG5529 585055003244 Helix-turn-helix domain; Region: HTH_36; pfam13730 585055003245 primosomal protein DnaI; Provisional; Region: PRK02854 585055003246 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585055003247 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585055003248 Methyltransferase domain; Region: Methyltransf_25; pfam13649 585055003249 Centrosome localisation domain of Cep57; Region: Cep57_CLD; pfam14073 585055003250 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055003251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055003252 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055003253 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055003254 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585055003255 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585055003256 Antitermination protein; Region: Antiterm; pfam03589 585055003257 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585055003258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055003259 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585055003260 DNA methylase; Region: N6_N4_Mtase; pfam01555 585055003261 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585055003262 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585055003263 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585055003264 Lysis protein S; Region: Lysis_S; pfam04971 585055003265 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585055003266 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585055003267 catalytic residues [active] 585055003268 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585055003269 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585055003270 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585055003271 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585055003272 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585055003273 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585055003274 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585055003275 oligomer interface [polypeptide binding]; other site 585055003276 active site residues [active] 585055003277 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585055003278 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 585055003279 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 585055003280 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585055003281 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585055003282 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585055003283 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585055003284 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585055003285 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 585055003286 Phage-related minor tail protein [Function unknown]; Region: COG5281 585055003287 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585055003288 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585055003289 Phage-related protein [Function unknown]; Region: COG4718 585055003290 Phage-related protein [Function unknown]; Region: gp18; COG4672 585055003291 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585055003292 MPN+ (JAMM) motif; other site 585055003293 Zinc-binding site [ion binding]; other site 585055003294 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585055003295 NlpC/P60 family; Region: NLPC_P60; cl17555 585055003296 Phage-related protein, tail component [Function unknown]; Region: COG4723 585055003297 Phage-related protein, tail component [Function unknown]; Region: COG4733 585055003298 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585055003299 Fibronectin type 3 domain; Region: FN3; smart00060 585055003300 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585055003301 Fibronectin type III protein; Region: DUF3672; pfam12421 585055003302 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585055003303 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585055003304 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 585055003305 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 585055003306 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585055003307 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585055003308 hydrogenase 1 large subunit; Provisional; Region: PRK10170 585055003309 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585055003310 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 585055003311 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585055003312 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585055003313 putative substrate-binding site; other site 585055003314 nickel binding site [ion binding]; other site 585055003315 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 585055003316 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 585055003317 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 585055003318 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 585055003319 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585055003320 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 585055003321 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 585055003322 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585055003323 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585055003324 catalytic core [active] 585055003325 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585055003326 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 585055003327 Chain length determinant protein; Region: Wzz; pfam02706 585055003328 Chain length determinant protein; Region: Wzz; cl15801 585055003329 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585055003330 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 585055003331 Nucleotide binding site [chemical binding]; other site 585055003332 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585055003333 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585055003334 active site 585055003335 polysaccharide export protein Wza; Provisional; Region: PRK15078 585055003336 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585055003337 SLBB domain; Region: SLBB; pfam10531 585055003338 SLBB domain; Region: SLBB; pfam10531 585055003339 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585055003340 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585055003341 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585055003342 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585055003343 DNA-binding site [nucleotide binding]; DNA binding site 585055003344 RNA-binding motif; other site 585055003345 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055003346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055003347 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055003348 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055003349 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585055003350 DNA-binding site [nucleotide binding]; DNA binding site 585055003351 RNA-binding motif; other site 585055003352 GnsA/GnsB family; Region: GnsAB; pfam08178 585055003353 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585055003354 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585055003355 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 585055003356 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055003357 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 585055003358 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 585055003359 HAMP domain; Region: HAMP; pfam00672 585055003360 dimerization interface [polypeptide binding]; other site 585055003361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055003362 dimer interface [polypeptide binding]; other site 585055003363 phosphorylation site [posttranslational modification] 585055003364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055003365 ATP binding site [chemical binding]; other site 585055003366 Mg2+ binding site [ion binding]; other site 585055003367 G-X-G motif; other site 585055003368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055003369 active site 585055003370 phosphorylation site [posttranslational modification] 585055003371 intermolecular recognition site; other site 585055003372 dimerization interface [polypeptide binding]; other site 585055003373 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585055003374 putative binding surface; other site 585055003375 active site 585055003376 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 585055003377 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 585055003378 putative ligand binding site [chemical binding]; other site 585055003379 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 585055003380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055003381 active site 585055003382 phosphorylation site [posttranslational modification] 585055003383 intermolecular recognition site; other site 585055003384 dimerization interface [polypeptide binding]; other site 585055003385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055003386 DNA binding site [nucleotide binding] 585055003387 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 585055003388 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585055003389 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 585055003390 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585055003391 molybdopterin cofactor binding site [chemical binding]; other site 585055003392 substrate binding site [chemical binding]; other site 585055003393 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585055003394 molybdopterin cofactor binding site; other site 585055003395 chaperone protein TorD; Validated; Region: torD; PRK04976 585055003396 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 585055003397 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 585055003398 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 585055003399 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585055003400 HSP70 interaction site [polypeptide binding]; other site 585055003401 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585055003402 substrate binding site [polypeptide binding]; other site 585055003403 dimer interface [polypeptide binding]; other site 585055003404 hypothetical protein; Provisional; Region: PRK09784 585055003405 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585055003406 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585055003407 catalytic core [active] 585055003408 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585055003409 hypothetical protein; Provisional; Region: PRK10174 585055003410 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 585055003411 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585055003412 General stress protein [General function prediction only]; Region: GsiB; COG3729 585055003413 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 585055003414 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 585055003415 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 585055003416 putative FMN binding site [chemical binding]; other site 585055003417 pyrimidine utilization protein D; Region: RutD; TIGR03611 585055003418 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585055003419 homotrimer interaction site [polypeptide binding]; other site 585055003420 putative active site [active] 585055003421 Isochorismatase family; Region: Isochorismatase; pfam00857 585055003422 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585055003423 catalytic triad [active] 585055003424 conserved cis-peptide bond; other site 585055003425 pyrimidine utilization protein A; Region: RutA; TIGR03612 585055003426 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585055003427 active site 585055003428 dimer interface [polypeptide binding]; other site 585055003429 non-prolyl cis peptide bond; other site 585055003430 insertion regions; other site 585055003431 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585055003432 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 585055003433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055003434 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 585055003435 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 585055003436 Predicted transcriptional regulator [Transcription]; Region: COG3905 585055003437 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 585055003438 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 585055003439 Glutamate binding site [chemical binding]; other site 585055003440 NAD binding site [chemical binding]; other site 585055003441 catalytic residues [active] 585055003442 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 585055003443 Na binding site [ion binding]; other site 585055003444 FTR1 family protein; Region: TIGR00145 585055003445 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 585055003446 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 585055003447 Imelysin; Region: Peptidase_M75; pfam09375 585055003448 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 585055003449 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 585055003450 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585055003451 hypothetical protein; Provisional; Region: PRK10536 585055003452 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 585055003453 N-glycosyltransferase; Provisional; Region: PRK11204 585055003454 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585055003455 DXD motif; other site 585055003456 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585055003457 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 585055003458 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 585055003459 putative active site [active] 585055003460 putative metal binding site [ion binding]; other site 585055003461 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 585055003462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055003463 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055003464 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055003465 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055003466 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055003467 fragment of diguanylate cyclase (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055003468 fragment of diguanylate cyclase (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055003469 putative transposase OrfB; Reviewed; Region: PHA02517 585055003470 HTH-like domain; Region: HTH_21; pfam13276 585055003471 Integrase core domain; Region: rve; pfam00665 585055003472 Integrase core domain; Region: rve_2; pfam13333 585055003473 Transposase; Region: HTH_Tnp_1; cl17663 585055003474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055003475 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 585055003476 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 585055003477 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 585055003478 putative ligand binding site [chemical binding]; other site 585055003479 NAD binding site [chemical binding]; other site 585055003480 dimerization interface [polypeptide binding]; other site 585055003481 catalytic site [active] 585055003482 putative hydrolase; Validated; Region: PRK09248 585055003483 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 585055003484 active site 585055003485 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 585055003486 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585055003487 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 585055003488 curli assembly protein CsgF; Provisional; Region: PRK10050 585055003489 curli assembly protein CsgE; Provisional; Region: PRK10386 585055003490 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 585055003491 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055003492 DNA binding residues [nucleotide binding] 585055003493 dimerization interface [polypeptide binding]; other site 585055003494 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 585055003495 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585055003496 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585055003497 major curlin subunit; Provisional; Region: csgA; PRK10051 585055003498 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585055003499 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585055003500 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 585055003501 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055003502 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 585055003503 putative ADP-ribose binding site [chemical binding]; other site 585055003504 putative active site [active] 585055003505 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 585055003506 PLD-like domain; Region: PLDc_2; pfam13091 585055003507 putative active site [active] 585055003508 catalytic site [active] 585055003509 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 585055003510 PLD-like domain; Region: PLDc_2; pfam13091 585055003511 putative active site [active] 585055003512 catalytic site [active] 585055003513 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 585055003514 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585055003515 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 585055003516 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 585055003517 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 585055003518 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 585055003519 Ligand binding site; other site 585055003520 DXD motif; other site 585055003521 lipoprotein; Provisional; Region: PRK10175 585055003522 secY/secA suppressor protein; Provisional; Region: PRK11467 585055003523 drug efflux system protein MdtG; Provisional; Region: PRK09874 585055003524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055003525 putative substrate translocation pore; other site 585055003526 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585055003527 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585055003528 putative acyl-acceptor binding pocket; other site 585055003529 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 585055003530 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 585055003531 active site residue [active] 585055003532 hypothetical protein; Provisional; Region: PRK03757 585055003533 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 585055003534 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 585055003535 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585055003536 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 585055003537 DNA damage-inducible protein I; Provisional; Region: PRK10597 585055003538 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 585055003539 active site 585055003540 substrate binding pocket [chemical binding]; other site 585055003541 dimer interface [polypeptide binding]; other site 585055003542 lipoprotein; Provisional; Region: PRK10598 585055003543 glutaredoxin 2; Provisional; Region: PRK10387 585055003544 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 585055003545 C-terminal domain interface [polypeptide binding]; other site 585055003546 GSH binding site (G-site) [chemical binding]; other site 585055003547 catalytic residues [active] 585055003548 putative dimer interface [polypeptide binding]; other site 585055003549 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 585055003550 N-terminal domain interface [polypeptide binding]; other site 585055003551 multidrug resistance protein MdtH; Provisional; Region: PRK11646 585055003552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055003553 putative substrate translocation pore; other site 585055003554 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 585055003555 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585055003556 hypothetical protein; Provisional; Region: PRK11239 585055003557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 585055003558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585055003559 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585055003560 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585055003561 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 585055003562 MviN-like protein; Region: MVIN; pfam03023 585055003563 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 585055003564 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 585055003565 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 585055003566 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 585055003567 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 585055003568 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 585055003569 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 585055003570 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 585055003571 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585055003572 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585055003573 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 585055003574 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 585055003575 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 585055003576 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 585055003577 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585055003578 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 585055003579 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585055003580 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 585055003581 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585055003582 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 585055003583 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 585055003584 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585055003585 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585055003586 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 585055003587 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 585055003588 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 585055003589 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 585055003590 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 585055003591 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 585055003592 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 585055003593 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 585055003594 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585055003595 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 585055003596 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 585055003597 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585055003598 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 585055003599 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585055003600 homodimer interface [polypeptide binding]; other site 585055003601 oligonucleotide binding site [chemical binding]; other site 585055003602 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 585055003603 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 585055003604 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055003605 RNA binding surface [nucleotide binding]; other site 585055003606 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585055003607 active site 585055003608 Maf-like protein; Region: Maf; pfam02545 585055003609 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585055003610 active site 585055003611 dimer interface [polypeptide binding]; other site 585055003612 hypothetical protein; Provisional; Region: PRK11193 585055003613 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 585055003614 putative phosphate acyltransferase; Provisional; Region: PRK05331 585055003615 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 585055003616 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 585055003617 dimer interface [polypeptide binding]; other site 585055003618 active site 585055003619 CoA binding pocket [chemical binding]; other site 585055003620 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 585055003621 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 585055003622 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 585055003623 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 585055003624 NAD(P) binding site [chemical binding]; other site 585055003625 homotetramer interface [polypeptide binding]; other site 585055003626 homodimer interface [polypeptide binding]; other site 585055003627 active site 585055003628 acyl carrier protein; Provisional; Region: acpP; PRK00982 585055003629 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 585055003630 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585055003631 dimer interface [polypeptide binding]; other site 585055003632 active site 585055003633 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585055003634 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 585055003635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055003636 catalytic residue [active] 585055003637 conserved hypothetical protein, YceG family; Region: TIGR00247 585055003638 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 585055003639 dimerization interface [polypeptide binding]; other site 585055003640 thymidylate kinase; Validated; Region: tmk; PRK00698 585055003641 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585055003642 TMP-binding site; other site 585055003643 ATP-binding site [chemical binding]; other site 585055003644 DNA polymerase III subunit delta'; Validated; Region: PRK07993 585055003645 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 585055003646 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585055003647 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585055003648 active site 585055003649 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 585055003650 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585055003651 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055003652 active site turn [active] 585055003653 phosphorylation site [posttranslational modification] 585055003654 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 585055003655 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055003656 N-terminal plug; other site 585055003657 ligand-binding site [chemical binding]; other site 585055003658 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 585055003659 nucleotide binding site/active site [active] 585055003660 HIT family signature motif; other site 585055003661 catalytic residue [active] 585055003662 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 585055003663 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 585055003664 putative dimer interface [polypeptide binding]; other site 585055003665 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 585055003666 thiamine kinase; Region: ycfN_thiK; TIGR02721 585055003667 active site 585055003668 substrate binding site [chemical binding]; other site 585055003669 ATP binding site [chemical binding]; other site 585055003670 thiamine kinase; Provisional; Region: thiK; PRK10271 585055003671 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 585055003672 beta-hexosaminidase; Provisional; Region: PRK05337 585055003673 hypothetical protein; Provisional; Region: PRK04940 585055003674 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 585055003675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055003676 hypothetical protein; Provisional; Region: PRK11280 585055003677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585055003678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055003679 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055003680 L,D-transpeptidase; Provisional; Region: PRK10260 585055003681 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055003682 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585055003683 transcription-repair coupling factor; Provisional; Region: PRK10689 585055003684 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 585055003685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055003686 ATP binding site [chemical binding]; other site 585055003687 putative Mg++ binding site [ion binding]; other site 585055003688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055003689 nucleotide binding region [chemical binding]; other site 585055003690 ATP-binding site [chemical binding]; other site 585055003691 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 585055003692 Predicted membrane protein [Function unknown]; Region: COG4763 585055003693 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585055003694 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 585055003695 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585055003696 FtsX-like permease family; Region: FtsX; pfam02687 585055003697 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 585055003698 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585055003699 Walker A/P-loop; other site 585055003700 ATP binding site [chemical binding]; other site 585055003701 Q-loop/lid; other site 585055003702 ABC transporter signature motif; other site 585055003703 Walker B; other site 585055003704 D-loop; other site 585055003705 H-loop/switch region; other site 585055003706 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 585055003707 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585055003708 FtsX-like permease family; Region: FtsX; pfam02687 585055003709 fructokinase; Reviewed; Region: PRK09557 585055003710 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055003711 nucleotide binding site [chemical binding]; other site 585055003712 NAD-dependent deacetylase; Provisional; Region: PRK00481 585055003713 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 585055003714 NAD+ binding site [chemical binding]; other site 585055003715 substrate binding site [chemical binding]; other site 585055003716 Zn binding site [ion binding]; other site 585055003717 Repair protein; Region: Repair_PSII; cl01535 585055003718 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 585055003719 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 585055003720 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 585055003721 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585055003722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055003723 dimer interface [polypeptide binding]; other site 585055003724 conserved gate region; other site 585055003725 putative PBP binding loops; other site 585055003726 ABC-ATPase subunit interface; other site 585055003727 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585055003728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055003729 dimer interface [polypeptide binding]; other site 585055003730 conserved gate region; other site 585055003731 putative PBP binding loops; other site 585055003732 ABC-ATPase subunit interface; other site 585055003733 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 585055003734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055003735 Walker A/P-loop; other site 585055003736 ATP binding site [chemical binding]; other site 585055003737 Q-loop/lid; other site 585055003738 ABC transporter signature motif; other site 585055003739 Walker B; other site 585055003740 D-loop; other site 585055003741 H-loop/switch region; other site 585055003742 TOBE domain; Region: TOBE_2; pfam08402 585055003743 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 585055003744 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 585055003745 metal binding site [ion binding]; metal-binding site 585055003746 dimer interface [polypeptide binding]; other site 585055003747 Uncharacterized conserved protein [Function unknown]; Region: COG2850 585055003748 Cupin-like domain; Region: Cupin_8; pfam13621 585055003749 sensor protein PhoQ; Provisional; Region: PRK10815 585055003750 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 585055003751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585055003752 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 585055003753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055003754 ATP binding site [chemical binding]; other site 585055003755 Mg2+ binding site [ion binding]; other site 585055003756 G-X-G motif; other site 585055003757 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 585055003758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055003759 active site 585055003760 phosphorylation site [posttranslational modification] 585055003761 intermolecular recognition site; other site 585055003762 dimerization interface [polypeptide binding]; other site 585055003763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055003764 DNA binding site [nucleotide binding] 585055003765 adenylosuccinate lyase; Provisional; Region: PRK09285 585055003766 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 585055003767 tetramer interface [polypeptide binding]; other site 585055003768 active site 585055003769 putative lysogenization regulator; Reviewed; Region: PRK00218 585055003770 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 585055003771 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 585055003772 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 585055003773 nudix motif; other site 585055003774 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 585055003775 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 585055003776 probable active site [active] 585055003777 isocitrate dehydrogenase; Validated; Region: PRK07362 585055003778 isocitrate dehydrogenase; Reviewed; Region: PRK07006 585055003779 anti-adapter protein IraM; Provisional; Region: PRK09919 585055003780 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585055003781 transcriptional regulator MirA; Provisional; Region: PRK15043 585055003782 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 585055003783 DNA binding residues [nucleotide binding] 585055003784 Sensors of blue-light using FAD; Region: BLUF; smart01034 585055003785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055003786 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585055003787 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585055003788 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585055003789 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055003790 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 585055003791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055003792 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055003793 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055003794 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055003795 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585055003796 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055003797 Autotransporter beta-domain; Region: Autotransporter; smart00869 585055003798 Autotransporter beta-domain; Region: Autotransporter; smart00869 585055003799 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 585055003800 cell division inhibitor MinD; Provisional; Region: PRK10818 585055003801 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 585055003802 Switch I; other site 585055003803 Switch II; other site 585055003804 septum formation inhibitor; Reviewed; Region: minC; PRK03511 585055003805 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 585055003806 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 585055003807 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585055003808 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585055003809 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 585055003810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 585055003811 hypothetical protein; Provisional; Region: PRK10691 585055003812 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 585055003813 hypothetical protein; Provisional; Region: PRK05170 585055003814 fragment of hemolysin E (part 2);Evidence 7 : Gene remnant; Product type c : carrier 585055003815 fragment of hemolysin E (part 1);Evidence 7 : Gene remnant; Product type c : carrier 585055003816 Haemolysin E (HlyE); Region: HlyE; cl11627 585055003817 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585055003818 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585055003819 Catalytic site [active] 585055003820 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 585055003821 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 585055003822 active site 585055003823 DNA binding site [nucleotide binding] 585055003824 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 585055003825 disulfide bond formation protein B; Provisional; Region: PRK01749 585055003826 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585055003827 fatty acid metabolism regulator; Provisional; Region: PRK04984 585055003828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055003829 DNA-binding site [nucleotide binding]; DNA binding site 585055003830 FadR C-terminal domain; Region: FadR_C; pfam07840 585055003831 SpoVR family protein; Provisional; Region: PRK11767 585055003832 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 585055003833 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 585055003834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055003835 alanine racemase; Reviewed; Region: dadX; PRK03646 585055003836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585055003837 active site 585055003838 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585055003839 substrate binding site [chemical binding]; other site 585055003840 catalytic residues [active] 585055003841 dimer interface [polypeptide binding]; other site 585055003842 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 585055003843 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585055003844 TrkA-C domain; Region: TrkA_C; pfam02080 585055003845 Transporter associated domain; Region: CorC_HlyC; smart01091 585055003846 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 585055003847 dimer interface [polypeptide binding]; other site 585055003848 catalytic triad [active] 585055003849 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 585055003850 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585055003851 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585055003852 catalytic residue [active] 585055003853 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 585055003854 Flagellar regulator YcgR; Region: YcgR; pfam07317 585055003855 PilZ domain; Region: PilZ; pfam07238 585055003856 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 585055003857 trehalase; Provisional; Region: treA; PRK13271 585055003858 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 585055003859 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 585055003860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 585055003861 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585055003862 dimerization domain swap beta strand [polypeptide binding]; other site 585055003863 regulatory protein interface [polypeptide binding]; other site 585055003864 active site 585055003865 regulatory phosphorylation site [posttranslational modification]; other site 585055003866 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585055003867 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585055003868 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 585055003869 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 585055003870 Dak1 domain; Region: Dak1; pfam02733 585055003871 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 585055003872 PAS domain; Region: PAS; smart00091 585055003873 putative active site [active] 585055003874 heme pocket [chemical binding]; other site 585055003875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055003876 Walker A motif; other site 585055003877 ATP binding site [chemical binding]; other site 585055003878 Walker B motif; other site 585055003879 arginine finger; other site 585055003880 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585055003881 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585055003882 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055003883 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055003884 GTP-binding protein YchF; Reviewed; Region: PRK09601 585055003885 YchF GTPase; Region: YchF; cd01900 585055003886 G1 box; other site 585055003887 GTP/Mg2+ binding site [chemical binding]; other site 585055003888 Switch I region; other site 585055003889 G2 box; other site 585055003890 Switch II region; other site 585055003891 G3 box; other site 585055003892 G4 box; other site 585055003893 G5 box; other site 585055003894 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 585055003895 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 585055003896 putative active site [active] 585055003897 catalytic residue [active] 585055003898 hypothetical protein; Provisional; Region: PRK10692 585055003899 putative transporter; Provisional; Region: PRK11660 585055003900 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 585055003901 Sulfate transporter family; Region: Sulfate_transp; pfam00916 585055003902 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 585055003903 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 585055003904 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 585055003905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055003906 active site 585055003907 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 585055003908 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585055003909 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 585055003910 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 585055003911 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 585055003912 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 585055003913 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 585055003914 tRNA; other site 585055003915 putative tRNA binding site [nucleotide binding]; other site 585055003916 putative NADP binding site [chemical binding]; other site 585055003917 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 585055003918 peptide chain release factor 1; Validated; Region: prfA; PRK00591 585055003919 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585055003920 RF-1 domain; Region: RF-1; pfam00472 585055003921 HemK family putative methylases; Region: hemK_fam; TIGR00536 585055003922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055003923 hypothetical protein; Provisional; Region: PRK10278 585055003924 hypothetical protein; Provisional; Region: PRK10941 585055003925 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 585055003926 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 585055003927 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585055003928 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585055003929 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585055003930 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 585055003931 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585055003932 cation transport regulator; Reviewed; Region: chaB; PRK09582 585055003933 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 585055003934 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585055003935 putative active site pocket [active] 585055003936 dimerization interface [polypeptide binding]; other site 585055003937 putative catalytic residue [active] 585055003938 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 585055003939 putative invasin; Provisional; Region: PRK10177 585055003940 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585055003941 transcriptional regulator NarL; Provisional; Region: PRK10651 585055003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055003943 active site 585055003944 phosphorylation site [posttranslational modification] 585055003945 intermolecular recognition site; other site 585055003946 dimerization interface [polypeptide binding]; other site 585055003947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055003948 DNA binding residues [nucleotide binding] 585055003949 dimerization interface [polypeptide binding]; other site 585055003950 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 585055003951 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585055003952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055003953 dimerization interface [polypeptide binding]; other site 585055003954 Histidine kinase; Region: HisKA_3; pfam07730 585055003955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055003956 ATP binding site [chemical binding]; other site 585055003957 Mg2+ binding site [ion binding]; other site 585055003958 G-X-G motif; other site 585055003959 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585055003960 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 585055003961 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585055003962 [4Fe-4S] binding site [ion binding]; other site 585055003963 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055003964 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055003965 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055003966 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585055003967 molybdopterin cofactor binding site; other site 585055003968 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585055003969 4Fe-4S binding domain; Region: Fer4; cl02805 585055003970 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 585055003971 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585055003972 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 585055003973 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 585055003974 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 585055003975 putative active site [active] 585055003976 putative substrate binding site [chemical binding]; other site 585055003977 putative cosubstrate binding site; other site 585055003978 catalytic site [active] 585055003979 SEC-C motif; Region: SEC-C; pfam02810 585055003980 hypothetical protein; Provisional; Region: PRK04233 585055003981 hypothetical protein; Provisional; Region: PRK10279 585055003982 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 585055003983 active site 585055003984 nucleophile elbow; other site 585055003985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055003986 active site 585055003987 response regulator of RpoS; Provisional; Region: PRK10693 585055003988 phosphorylation site [posttranslational modification] 585055003989 intermolecular recognition site; other site 585055003990 dimerization interface [polypeptide binding]; other site 585055003991 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585055003992 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 585055003993 active site 585055003994 tetramer interface; other site 585055003995 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 585055003996 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585055003997 thymidine kinase; Provisional; Region: PRK04296 585055003998 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 585055003999 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 585055004000 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 585055004001 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 585055004002 putative catalytic cysteine [active] 585055004003 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 585055004004 putative active site [active] 585055004005 metal binding site [ion binding]; metal-binding site 585055004006 hypothetical protein; Provisional; Region: PRK11111 585055004007 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055004008 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585055004009 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585055004010 peptide binding site [polypeptide binding]; other site 585055004011 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 585055004012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004013 dimer interface [polypeptide binding]; other site 585055004014 conserved gate region; other site 585055004015 putative PBP binding loops; other site 585055004016 ABC-ATPase subunit interface; other site 585055004017 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 585055004018 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585055004019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004020 dimer interface [polypeptide binding]; other site 585055004021 conserved gate region; other site 585055004022 putative PBP binding loops; other site 585055004023 ABC-ATPase subunit interface; other site 585055004024 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 585055004025 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055004026 Walker A/P-loop; other site 585055004027 ATP binding site [chemical binding]; other site 585055004028 Q-loop/lid; other site 585055004029 ABC transporter signature motif; other site 585055004030 Walker B; other site 585055004031 D-loop; other site 585055004032 H-loop/switch region; other site 585055004033 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585055004034 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 585055004035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055004036 Walker A/P-loop; other site 585055004037 ATP binding site [chemical binding]; other site 585055004038 Q-loop/lid; other site 585055004039 ABC transporter signature motif; other site 585055004040 Walker B; other site 585055004041 D-loop; other site 585055004042 H-loop/switch region; other site 585055004043 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585055004044 dsDNA-mimic protein; Reviewed; Region: PRK05094 585055004045 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 585055004046 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 585055004047 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 585055004048 putative active site [active] 585055004049 catalytic site [active] 585055004050 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 585055004051 putative active site [active] 585055004052 catalytic site [active] 585055004053 voltage-gated potassium channel; Provisional; Region: PRK10537 585055004054 Ion channel; Region: Ion_trans_2; pfam07885 585055004055 TrkA-N domain; Region: TrkA_N; pfam02254 585055004056 YciI-like protein; Reviewed; Region: PRK11370 585055004057 transport protein TonB; Provisional; Region: PRK10819 585055004058 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 585055004059 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 585055004060 intracellular septation protein A; Reviewed; Region: PRK00259 585055004061 hypothetical protein; Provisional; Region: PRK02868 585055004062 outer membrane protein W; Provisional; Region: PRK10959 585055004063 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585055004064 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585055004065 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585055004066 dimer interface [polypeptide binding]; other site 585055004067 active site 585055004068 Int/Topo IB signature motif; other site 585055004069 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585055004070 active site 585055004071 substrate binding site [chemical binding]; other site 585055004072 catalytic site [active] 585055004073 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585055004074 DicB protein; Region: DicB; pfam05358 585055004075 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585055004076 transcriptional repressor DicA; Reviewed; Region: PRK09706 585055004077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055004078 non-specific DNA binding site [nucleotide binding]; other site 585055004079 salt bridge; other site 585055004080 sequence-specific DNA binding site [nucleotide binding]; other site 585055004081 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585055004082 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585055004083 primosomal protein DnaI; Provisional; Region: PRK02854 585055004084 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585055004085 Methyltransferase domain; Region: Methyltransf_23; pfam13489 585055004086 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585055004087 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585055004088 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585055004089 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 585055004090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 585055004091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 585055004092 active site 585055004093 ATP binding site [chemical binding]; other site 585055004094 substrate binding site [chemical binding]; other site 585055004095 activation loop (A-loop); other site 585055004096 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 585055004097 fragment of DNA adenine methyltransferase ( DNA methylase) from phage origin (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055004098 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585055004099 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585055004100 fragment of Lysis protein S homolog from lambdoid prophage (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055004101 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055004102 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585055004103 catalytic residues [active] 585055004104 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585055004105 Beta protein; Region: Beta_protein; pfam14350 585055004106 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 585055004107 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585055004108 gpW; Region: gpW; pfam02831 585055004109 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585055004110 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585055004111 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585055004112 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585055004113 tandem repeat interface [polypeptide binding]; other site 585055004114 oligomer interface [polypeptide binding]; other site 585055004115 active site residues [active] 585055004116 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585055004117 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585055004118 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585055004119 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585055004120 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585055004121 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585055004122 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585055004123 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585055004124 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585055004125 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 585055004126 Phage-related minor tail protein [Function unknown]; Region: COG5281 585055004127 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585055004128 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585055004129 Phage-related protein [Function unknown]; Region: COG4718 585055004130 Phage-related protein [Function unknown]; Region: gp18; COG4672 585055004131 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585055004132 MPN+ (JAMM) motif; other site 585055004133 Zinc-binding site [ion binding]; other site 585055004134 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585055004135 NlpC/P60 family; Region: NLPC_P60; cl17555 585055004136 Phage-related protein, tail component [Function unknown]; Region: COG4723 585055004137 Phage-related protein, tail component [Function unknown]; Region: COG4733 585055004138 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585055004139 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585055004140 Interdomain contacts; other site 585055004141 Cytokine receptor motif; other site 585055004142 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585055004143 Fibronectin type III protein; Region: DUF3672; pfam12421 585055004144 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585055004145 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585055004146 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585055004147 Phage Tail Collar Domain; Region: Collar; pfam07484 585055004148 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585055004149 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585055004150 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585055004151 S-adenosylmethionine binding site [chemical binding]; other site 585055004152 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585055004153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 585055004154 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 585055004155 dimerization interface [polypeptide binding]; other site 585055004156 metal binding site [ion binding]; metal-binding site 585055004157 General stress protein [General function prediction only]; Region: GsiB; COG3729 585055004158 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 585055004159 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 585055004160 substrate binding site [chemical binding]; other site 585055004161 active site 585055004162 catalytic residues [active] 585055004163 heterodimer interface [polypeptide binding]; other site 585055004164 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 585055004165 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 585055004166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055004167 catalytic residue [active] 585055004168 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 585055004169 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 585055004170 active site 585055004171 ribulose/triose binding site [chemical binding]; other site 585055004172 phosphate binding site [ion binding]; other site 585055004173 substrate (anthranilate) binding pocket [chemical binding]; other site 585055004174 product (indole) binding pocket [chemical binding]; other site 585055004175 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 585055004176 active site 585055004177 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 585055004178 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585055004179 glutamine binding [chemical binding]; other site 585055004180 catalytic triad [active] 585055004181 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585055004182 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585055004183 anthranilate synthase component I; Provisional; Region: PRK13564 585055004184 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585055004185 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585055004186 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 585055004187 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585055004188 active site 585055004189 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585055004190 hypothetical protein; Provisional; Region: PRK11630 585055004191 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 585055004192 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055004193 RNA binding surface [nucleotide binding]; other site 585055004194 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 585055004195 probable active site [active] 585055004196 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 585055004197 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 585055004198 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 585055004199 homodimer interface [polypeptide binding]; other site 585055004200 Walker A motif; other site 585055004201 ATP binding site [chemical binding]; other site 585055004202 hydroxycobalamin binding site [chemical binding]; other site 585055004203 Walker B motif; other site 585055004204 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 585055004205 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 585055004206 NADP binding site [chemical binding]; other site 585055004207 homodimer interface [polypeptide binding]; other site 585055004208 active site 585055004209 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 585055004210 putative inner membrane peptidase; Provisional; Region: PRK11778 585055004211 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 585055004212 tandem repeat interface [polypeptide binding]; other site 585055004213 oligomer interface [polypeptide binding]; other site 585055004214 active site residues [active] 585055004215 hypothetical protein; Provisional; Region: PRK11037 585055004216 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 585055004217 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 585055004218 active site 585055004219 interdomain interaction site; other site 585055004220 putative metal-binding site [ion binding]; other site 585055004221 nucleotide binding site [chemical binding]; other site 585055004222 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585055004223 domain I; other site 585055004224 DNA binding groove [nucleotide binding] 585055004225 phosphate binding site [ion binding]; other site 585055004226 domain II; other site 585055004227 domain III; other site 585055004228 nucleotide binding site [chemical binding]; other site 585055004229 catalytic site [active] 585055004230 domain IV; other site 585055004231 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585055004232 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585055004233 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585055004234 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585055004235 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 585055004236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055004237 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 585055004238 substrate binding site [chemical binding]; other site 585055004239 putative dimerization interface [polypeptide binding]; other site 585055004240 aconitate hydratase; Validated; Region: PRK09277 585055004241 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 585055004242 substrate binding site [chemical binding]; other site 585055004243 ligand binding site [chemical binding]; other site 585055004244 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 585055004245 substrate binding site [chemical binding]; other site 585055004246 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 585055004247 dimerization interface [polypeptide binding]; other site 585055004248 active site 585055004249 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585055004250 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585055004251 active site 585055004252 Predicted membrane protein [Function unknown]; Region: COG3771 585055004253 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 585055004254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585055004255 TPR motif; other site 585055004256 binding surface 585055004257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055004258 binding surface 585055004259 TPR motif; other site 585055004260 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 585055004261 active site 585055004262 dimer interface [polypeptide binding]; other site 585055004263 translation initiation factor Sui1; Validated; Region: PRK06824 585055004264 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 585055004265 putative rRNA binding site [nucleotide binding]; other site 585055004266 lipoprotein; Provisional; Region: PRK10540 585055004267 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585055004268 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585055004269 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055004270 hypothetical protein; Provisional; Region: PRK13658 585055004271 RNase II stability modulator; Provisional; Region: PRK10060 585055004272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055004273 putative active site [active] 585055004274 heme pocket [chemical binding]; other site 585055004275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055004276 metal binding site [ion binding]; metal-binding site 585055004277 active site 585055004278 I-site; other site 585055004279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055004280 exoribonuclease II; Provisional; Region: PRK05054 585055004281 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585055004282 RNB domain; Region: RNB; pfam00773 585055004283 S1 RNA binding domain; Region: S1; pfam00575 585055004284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 585055004285 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585055004286 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 585055004287 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 585055004288 NAD binding site [chemical binding]; other site 585055004289 homotetramer interface [polypeptide binding]; other site 585055004290 homodimer interface [polypeptide binding]; other site 585055004291 substrate binding site [chemical binding]; other site 585055004292 active site 585055004293 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 585055004294 putative active site [active] 585055004295 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 585055004296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055004297 Walker A/P-loop; other site 585055004298 ATP binding site [chemical binding]; other site 585055004299 Q-loop/lid; other site 585055004300 ABC transporter signature motif; other site 585055004301 Walker B; other site 585055004302 D-loop; other site 585055004303 H-loop/switch region; other site 585055004304 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 585055004305 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055004306 Walker A/P-loop; other site 585055004307 ATP binding site [chemical binding]; other site 585055004308 Q-loop/lid; other site 585055004309 ABC transporter signature motif; other site 585055004310 Walker B; other site 585055004311 D-loop; other site 585055004312 H-loop/switch region; other site 585055004313 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585055004314 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 585055004315 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585055004316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004317 dimer interface [polypeptide binding]; other site 585055004318 conserved gate region; other site 585055004319 putative PBP binding loops; other site 585055004320 ABC-ATPase subunit interface; other site 585055004321 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 585055004322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004323 dimer interface [polypeptide binding]; other site 585055004324 conserved gate region; other site 585055004325 putative PBP binding loops; other site 585055004326 ABC-ATPase subunit interface; other site 585055004327 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585055004328 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585055004329 peptide binding site [polypeptide binding]; other site 585055004330 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 585055004331 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585055004332 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 585055004333 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585055004334 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 585055004335 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 585055004336 catalytic triad [active] 585055004337 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 585055004338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055004339 non-specific DNA binding site [nucleotide binding]; other site 585055004340 salt bridge; other site 585055004341 sequence-specific DNA binding site [nucleotide binding]; other site 585055004342 Cupin domain; Region: Cupin_2; pfam07883 585055004343 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 585055004344 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 585055004345 NAD(P) binding site [chemical binding]; other site 585055004346 catalytic residues [active] 585055004347 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 585055004348 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 585055004349 4-aminobutyrate transaminase; Provisional; Region: PRK09792 585055004350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585055004351 inhibitor-cofactor binding pocket; inhibition site 585055004352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055004353 catalytic residue [active] 585055004354 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 585055004355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055004356 Walker A motif; other site 585055004357 ATP binding site [chemical binding]; other site 585055004358 Walker B motif; other site 585055004359 arginine finger; other site 585055004360 phage shock protein PspA; Provisional; Region: PRK10698 585055004361 phage shock protein B; Provisional; Region: pspB; PRK09458 585055004362 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 585055004363 phage shock protein C; Region: phageshock_pspC; TIGR02978 585055004364 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 585055004365 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585055004366 active site residue [active] 585055004367 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 585055004368 sucrose phosphorylase; Provisional; Region: PRK13840 585055004369 active site 585055004370 homodimer interface [polypeptide binding]; other site 585055004371 catalytic site [active] 585055004372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585055004373 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585055004374 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585055004375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004376 dimer interface [polypeptide binding]; other site 585055004377 conserved gate region; other site 585055004378 putative PBP binding loops; other site 585055004379 ABC-ATPase subunit interface; other site 585055004380 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585055004381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004382 dimer interface [polypeptide binding]; other site 585055004383 conserved gate region; other site 585055004384 putative PBP binding loops; other site 585055004385 ABC-ATPase subunit interface; other site 585055004386 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585055004387 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 585055004388 putative NAD(P) binding site [chemical binding]; other site 585055004389 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 585055004390 fragment of oxidoreductase, NADH-binding (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055004391 fragment of oxidoreductase, NADH-binding (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055004392 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 585055004393 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 585055004394 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 585055004395 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 585055004396 beta-phosphoglucomutase; Region: bPGM; TIGR01990 585055004397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055004398 motif II; other site 585055004399 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 585055004400 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585055004401 Walker A/P-loop; other site 585055004402 ATP binding site [chemical binding]; other site 585055004403 Q-loop/lid; other site 585055004404 ABC transporter signature motif; other site 585055004405 Walker B; other site 585055004406 D-loop; other site 585055004407 H-loop/switch region; other site 585055004408 TOBE domain; Region: TOBE_2; pfam08402 585055004409 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 585055004410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585055004411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055004412 DNA binding site [nucleotide binding] 585055004413 domain linker motif; other site 585055004414 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 585055004415 putative dimerization interface [polypeptide binding]; other site 585055004416 putative ligand binding site [chemical binding]; other site 585055004417 Predicted ATPase [General function prediction only]; Region: COG3106 585055004418 Predicted membrane protein [Function unknown]; Region: COG3768 585055004419 TIGR01620 family protein; Region: hyp_HI0043 585055004420 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 585055004421 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 585055004422 putative aromatic amino acid binding site; other site 585055004423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055004424 Walker A motif; other site 585055004425 ATP binding site [chemical binding]; other site 585055004426 Walker B motif; other site 585055004427 arginine finger; other site 585055004428 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 585055004429 dimer interface [polypeptide binding]; other site 585055004430 catalytic triad [active] 585055004431 peroxidatic and resolving cysteines [active] 585055004432 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 585055004433 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 585055004434 active site 585055004435 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 585055004436 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 585055004437 putative active site [active] 585055004438 Zn binding site [ion binding]; other site 585055004439 fragment of NAD(P) binding enzyme (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055004440 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585055004441 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585055004442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055004443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055004444 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585055004445 putative effector binding pocket; other site 585055004446 putative dimerization interface [polypeptide binding]; other site 585055004447 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585055004448 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585055004449 peptide binding site [polypeptide binding]; other site 585055004450 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585055004451 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585055004452 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 585055004453 universal stress protein UspE; Provisional; Region: PRK11175 585055004454 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585055004455 Ligand Binding Site [chemical binding]; other site 585055004456 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585055004457 Ligand Binding Site [chemical binding]; other site 585055004458 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 585055004459 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585055004460 ligand binding site [chemical binding]; other site 585055004461 flexible hinge region; other site 585055004462 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585055004463 putative switch regulator; other site 585055004464 non-specific DNA interactions [nucleotide binding]; other site 585055004465 DNA binding site [nucleotide binding] 585055004466 sequence specific DNA binding site [nucleotide binding]; other site 585055004467 putative cAMP binding site [chemical binding]; other site 585055004468 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 585055004469 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585055004470 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585055004471 DNA binding site [nucleotide binding] 585055004472 active site 585055004473 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 585055004474 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 585055004475 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 585055004476 amidohydrolase; Region: amidohydrolases; TIGR01891 585055004477 putative metal binding site [ion binding]; other site 585055004478 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 585055004479 amidohydrolase; Region: amidohydrolases; TIGR01891 585055004480 putative metal binding site [ion binding]; other site 585055004481 dimer interface [polypeptide binding]; other site 585055004482 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 585055004483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055004484 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 585055004485 putative substrate binding pocket [chemical binding]; other site 585055004486 putative dimerization interface [polypeptide binding]; other site 585055004487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 585055004488 Smr domain; Region: Smr; pfam01713 585055004489 PAS domain S-box; Region: sensory_box; TIGR00229 585055004490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055004491 putative active site [active] 585055004492 heme pocket [chemical binding]; other site 585055004493 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055004494 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055004495 metal binding site [ion binding]; metal-binding site 585055004496 active site 585055004497 I-site; other site 585055004498 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585055004499 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 585055004500 Cl binding site [ion binding]; other site 585055004501 oligomer interface [polypeptide binding]; other site 585055004502 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 585055004503 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585055004504 ATP binding site [chemical binding]; other site 585055004505 Mg++ binding site [ion binding]; other site 585055004506 motif III; other site 585055004507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055004508 nucleotide binding region [chemical binding]; other site 585055004509 ATP-binding site [chemical binding]; other site 585055004510 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 585055004511 putative RNA binding site [nucleotide binding]; other site 585055004512 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 585055004513 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 585055004514 Ligand Binding Site [chemical binding]; other site 585055004515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585055004516 Ligand Binding Site [chemical binding]; other site 585055004517 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585055004518 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585055004519 trimer interface [polypeptide binding]; other site 585055004520 eyelet of channel; other site 585055004521 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 585055004522 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 585055004523 dimer interface [polypeptide binding]; other site 585055004524 PYR/PP interface [polypeptide binding]; other site 585055004525 TPP binding site [chemical binding]; other site 585055004526 substrate binding site [chemical binding]; other site 585055004527 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 585055004528 Domain of unknown function; Region: EKR; smart00890 585055004529 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585055004530 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055004531 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 585055004532 TPP-binding site [chemical binding]; other site 585055004533 dimer interface [polypeptide binding]; other site 585055004534 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585055004535 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585055004536 heat-inducible protein; Provisional; Region: PRK10449 585055004537 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 585055004538 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 585055004539 putative ligand binding site [chemical binding]; other site 585055004540 putative NAD binding site [chemical binding]; other site 585055004541 catalytic site [active] 585055004542 hypothetical protein; Provisional; Region: PRK10695 585055004543 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 585055004544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 585055004545 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 585055004546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055004547 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 585055004548 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585055004549 NAD(P) binding site [chemical binding]; other site 585055004550 catalytic residues [active] 585055004551 tyramine oxidase; Provisional; Region: tynA; PRK14696 585055004552 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 585055004553 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 585055004554 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 585055004555 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 585055004556 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 585055004557 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 585055004558 substrate binding site [chemical binding]; other site 585055004559 dimer interface [polypeptide binding]; other site 585055004560 NADP binding site [chemical binding]; other site 585055004561 catalytic residues [active] 585055004562 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 585055004563 substrate binding site [chemical binding]; other site 585055004564 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 585055004565 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 585055004566 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 585055004567 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 585055004568 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 585055004569 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 585055004570 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 585055004571 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 585055004572 FAD binding pocket [chemical binding]; other site 585055004573 FAD binding motif [chemical binding]; other site 585055004574 phosphate binding motif [ion binding]; other site 585055004575 beta-alpha-beta structure motif; other site 585055004576 NAD(p) ribose binding residues [chemical binding]; other site 585055004577 NAD binding pocket [chemical binding]; other site 585055004578 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 585055004579 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055004580 catalytic loop [active] 585055004581 iron binding site [ion binding]; other site 585055004582 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 585055004583 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585055004584 substrate binding site [chemical binding]; other site 585055004585 oxyanion hole (OAH) forming residues; other site 585055004586 trimer interface [polypeptide binding]; other site 585055004587 enoyl-CoA hydratase; Provisional; Region: PRK08140 585055004588 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585055004589 substrate binding site [chemical binding]; other site 585055004590 oxyanion hole (OAH) forming residues; other site 585055004591 trimer interface [polypeptide binding]; other site 585055004592 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 585055004593 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585055004594 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585055004595 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585055004596 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585055004597 CoenzymeA binding site [chemical binding]; other site 585055004598 subunit interaction site [polypeptide binding]; other site 585055004599 PHB binding site; other site 585055004600 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 585055004601 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585055004602 dimer interface [polypeptide binding]; other site 585055004603 active site 585055004604 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 585055004605 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 585055004606 active site 585055004607 AMP binding site [chemical binding]; other site 585055004608 homodimer interface [polypeptide binding]; other site 585055004609 acyl-activating enzyme (AAE) consensus motif; other site 585055004610 CoA binding site [chemical binding]; other site 585055004611 PaaX-like protein; Region: PaaX; pfam07848 585055004612 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 585055004613 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 585055004614 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 585055004615 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585055004616 putative trimer interface [polypeptide binding]; other site 585055004617 putative metal binding site [ion binding]; other site 585055004618 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055004619 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055004620 active site 585055004621 catalytic tetrad [active] 585055004622 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 585055004623 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 585055004624 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585055004625 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 585055004626 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585055004627 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 585055004628 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585055004629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055004630 S-adenosylmethionine binding site [chemical binding]; other site 585055004631 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 585055004632 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585055004633 active site 585055004634 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 585055004635 active site 585055004636 catalytic residues [active] 585055004637 azoreductase; Reviewed; Region: PRK00170 585055004638 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585055004639 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 585055004640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055004641 ATP binding site [chemical binding]; other site 585055004642 putative Mg++ binding site [ion binding]; other site 585055004643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055004644 nucleotide binding region [chemical binding]; other site 585055004645 ATP-binding site [chemical binding]; other site 585055004646 Helicase associated domain (HA2); Region: HA2; pfam04408 585055004647 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 585055004648 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 585055004649 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585055004650 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585055004651 putative active site [active] 585055004652 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 585055004653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585055004654 NAD binding site [chemical binding]; other site 585055004655 catalytic residues [active] 585055004656 substrate binding site [chemical binding]; other site 585055004657 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 585055004658 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585055004659 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585055004660 cytochrome b561; Provisional; Region: PRK11513 585055004661 hypothetical protein; Provisional; Region: PRK10040 585055004662 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585055004663 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585055004664 dimer interface [polypeptide binding]; other site 585055004665 ligand binding site [chemical binding]; other site 585055004666 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055004667 dimerization interface [polypeptide binding]; other site 585055004668 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585055004669 dimer interface [polypeptide binding]; other site 585055004670 putative CheW interface [polypeptide binding]; other site 585055004671 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 585055004672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055004673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055004674 dimerization interface [polypeptide binding]; other site 585055004675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585055004676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585055004677 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 585055004678 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 585055004679 hypothetical protein; Provisional; Region: PRK11415 585055004680 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585055004681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055004682 Coenzyme A binding pocket [chemical binding]; other site 585055004683 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 585055004684 putative trimer interface [polypeptide binding]; other site 585055004685 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585055004686 putative CoA binding site [chemical binding]; other site 585055004687 putative trimer interface [polypeptide binding]; other site 585055004688 putative CoA binding site [chemical binding]; other site 585055004689 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 585055004690 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 585055004691 gating phenylalanine in ion channel; other site 585055004692 tellurite resistance protein TehB; Provisional; Region: PRK11207 585055004693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055004694 S-adenosylmethionine binding site [chemical binding]; other site 585055004695 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 585055004696 Transposase IS200 like; Region: Y1_Tnp; cl00848 585055004697 Transposase IS200 like; Region: Y1_Tnp; cl00848 585055004698 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585055004699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 585055004700 Probable transposase; Region: OrfB_IS605; pfam01385 585055004701 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585055004702 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 585055004703 benzoate transporter; Region: benE; TIGR00843 585055004704 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585055004705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055004706 non-specific DNA binding site [nucleotide binding]; other site 585055004707 salt bridge; other site 585055004708 sequence-specific DNA binding site [nucleotide binding]; other site 585055004709 Cupin domain; Region: Cupin_2; pfam07883 585055004710 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585055004711 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585055004712 Peptidase family U32; Region: Peptidase_U32; pfam01136 585055004713 Collagenase; Region: DUF3656; pfam12392 585055004714 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 585055004715 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 585055004716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055004717 sequence-specific DNA binding site [nucleotide binding]; other site 585055004718 salt bridge; other site 585055004719 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585055004720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055004721 DNA-binding site [nucleotide binding]; DNA binding site 585055004722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055004723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055004724 homodimer interface [polypeptide binding]; other site 585055004725 catalytic residue [active] 585055004726 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 585055004727 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 585055004728 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 585055004729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055004730 Walker A/P-loop; other site 585055004731 ATP binding site [chemical binding]; other site 585055004732 Q-loop/lid; other site 585055004733 ABC transporter signature motif; other site 585055004734 Walker B; other site 585055004735 D-loop; other site 585055004736 H-loop/switch region; other site 585055004737 TOBE domain; Region: TOBE_2; pfam08402 585055004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004739 dimer interface [polypeptide binding]; other site 585055004740 conserved gate region; other site 585055004741 putative PBP binding loops; other site 585055004742 ABC-ATPase subunit interface; other site 585055004743 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585055004744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004745 ABC-ATPase subunit interface; other site 585055004746 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 585055004747 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 585055004748 tetrameric interface [polypeptide binding]; other site 585055004749 NAD binding site [chemical binding]; other site 585055004750 catalytic residues [active] 585055004751 substrate binding site [chemical binding]; other site 585055004752 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 585055004753 trimer interface [polypeptide binding]; other site 585055004754 active site 585055004755 substrate binding site [chemical binding]; other site 585055004756 CoA binding site [chemical binding]; other site 585055004757 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 585055004758 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 585055004759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 585055004760 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 585055004761 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585055004762 Coenzyme A binding pocket [chemical binding]; other site 585055004763 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 585055004764 Prostaglandin dehydrogenases; Region: PGDH; cd05288 585055004765 NAD(P) binding site [chemical binding]; other site 585055004766 substrate binding site [chemical binding]; other site 585055004767 dimer interface [polypeptide binding]; other site 585055004768 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 585055004769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055004770 DNA-binding site [nucleotide binding]; DNA binding site 585055004771 FCD domain; Region: FCD; pfam07729 585055004772 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585055004773 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055004774 N-terminal plug; other site 585055004775 ligand-binding site [chemical binding]; other site 585055004776 PQQ-like domain; Region: PQQ_2; pfam13360 585055004777 L-asparagine permease; Provisional; Region: PRK15049 585055004778 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585055004779 C-terminal domain interface [polypeptide binding]; other site 585055004780 GSH binding site (G-site) [chemical binding]; other site 585055004781 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585055004782 dimer interface [polypeptide binding]; other site 585055004783 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585055004784 dimer interface [polypeptide binding]; other site 585055004785 N-terminal domain interface [polypeptide binding]; other site 585055004786 substrate binding pocket (H-site) [chemical binding]; other site 585055004787 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585055004788 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585055004789 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585055004790 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585055004791 PAAR motif; Region: PAAR_motif; cl15808 585055004792 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055004793 RHS Repeat; Region: RHS_repeat; pfam05593 585055004794 RHS Repeat; Region: RHS_repeat; pfam05593 585055004795 RHS Repeat; Region: RHS_repeat; pfam05593 585055004796 RHS Repeat; Region: RHS_repeat; pfam05593 585055004797 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055004798 RHS Repeat; Region: RHS_repeat; pfam05593 585055004799 RHS Repeat; Region: RHS_repeat; pfam05593 585055004800 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 585055004801 RHS protein; Region: RHS; pfam03527 585055004802 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055004803 fragment of transposase (partial);Evidence 7 : Gene remnant; Product type ph : phenotype 585055004804 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 585055004805 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 585055004806 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 585055004807 hypothetical protein; Provisional; Region: PRK10281 585055004808 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585055004809 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 585055004810 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585055004811 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 585055004812 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585055004813 [4Fe-4S] binding site [ion binding]; other site 585055004814 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055004815 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055004816 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055004817 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585055004818 molybdopterin cofactor binding site; other site 585055004819 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585055004820 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 585055004821 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585055004822 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585055004823 aromatic amino acid exporter; Provisional; Region: PRK11689 585055004824 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585055004825 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585055004826 [4Fe-4S] binding site [ion binding]; other site 585055004827 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055004828 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585055004829 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585055004830 molybdopterin cofactor binding site; other site 585055004831 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585055004832 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585055004833 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 585055004834 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585055004835 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585055004836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055004837 non-specific DNA binding site [nucleotide binding]; other site 585055004838 salt bridge; other site 585055004839 sequence-specific DNA binding site [nucleotide binding]; other site 585055004840 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 585055004841 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 585055004842 NAD binding site [chemical binding]; other site 585055004843 substrate binding site [chemical binding]; other site 585055004844 catalytic Zn binding site [ion binding]; other site 585055004845 tetramer interface [polypeptide binding]; other site 585055004846 structural Zn binding site [ion binding]; other site 585055004847 malate dehydrogenase; Provisional; Region: PRK13529 585055004848 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585055004849 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 585055004850 NAD(P) binding site [chemical binding]; other site 585055004851 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 585055004852 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 585055004853 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 585055004854 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055004855 Walker A/P-loop; other site 585055004856 ATP binding site [chemical binding]; other site 585055004857 Q-loop/lid; other site 585055004858 ABC transporter signature motif; other site 585055004859 Walker B; other site 585055004860 D-loop; other site 585055004861 H-loop/switch region; other site 585055004862 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585055004863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 585055004864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055004865 Walker A/P-loop; other site 585055004866 ATP binding site [chemical binding]; other site 585055004867 Q-loop/lid; other site 585055004868 ABC transporter signature motif; other site 585055004869 Walker B; other site 585055004870 D-loop; other site 585055004871 H-loop/switch region; other site 585055004872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585055004873 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 585055004874 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585055004875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004876 dimer interface [polypeptide binding]; other site 585055004877 conserved gate region; other site 585055004878 putative PBP binding loops; other site 585055004879 ABC-ATPase subunit interface; other site 585055004880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585055004881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055004882 dimer interface [polypeptide binding]; other site 585055004883 conserved gate region; other site 585055004884 putative PBP binding loops; other site 585055004885 ABC-ATPase subunit interface; other site 585055004886 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585055004887 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 585055004888 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 585055004889 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 585055004890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055004891 putative active site [active] 585055004892 heme pocket [chemical binding]; other site 585055004893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055004894 putative active site [active] 585055004895 heme pocket [chemical binding]; other site 585055004896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055004897 metal binding site [ion binding]; metal-binding site 585055004898 active site 585055004899 I-site; other site 585055004900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055004901 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 585055004902 heme-binding site [chemical binding]; other site 585055004903 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055004904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055004905 metal binding site [ion binding]; metal-binding site 585055004906 active site 585055004907 I-site; other site 585055004908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 585055004909 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 585055004910 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 585055004911 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585055004912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055004913 catalytic residue [active] 585055004914 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585055004915 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585055004916 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585055004917 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585055004918 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585055004919 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585055004920 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585055004921 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 585055004922 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 585055004923 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 585055004924 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585055004925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055004926 FeS/SAM binding site; other site 585055004927 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585055004928 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585055004929 Sulfatase; Region: Sulfatase; pfam00884 585055004930 transcriptional regulator YdeO; Provisional; Region: PRK09940 585055004931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055004932 putative oxidoreductase; Provisional; Region: PRK09939 585055004933 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 585055004934 putative molybdopterin cofactor binding site [chemical binding]; other site 585055004935 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 585055004936 putative molybdopterin cofactor binding site; other site 585055004937 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 585055004938 mannosyl binding site [chemical binding]; other site 585055004939 Fimbrial protein; Region: Fimbrial; pfam00419 585055004940 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585055004941 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585055004942 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585055004943 PapC N-terminal domain; Region: PapC_N; pfam13954 585055004944 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055004945 PapC C-terminal domain; Region: PapC_C; pfam13953 585055004946 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585055004947 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055004948 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055004949 Fimbrial protein; Region: Fimbrial; cl01416 585055004950 Helix-turn-helix domain; Region: HTH_18; pfam12833 585055004951 HipA N-terminal domain; Region: Couple_hipA; pfam13657 585055004952 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 585055004953 HipA-like N-terminal domain; Region: HipA_N; pfam07805 585055004954 HipA-like C-terminal domain; Region: HipA_C; pfam07804 585055004955 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585055004956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055004957 non-specific DNA binding site [nucleotide binding]; other site 585055004958 salt bridge; other site 585055004959 sequence-specific DNA binding site [nucleotide binding]; other site 585055004960 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 585055004961 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585055004962 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585055004963 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055004964 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 585055004965 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 585055004966 putative N- and C-terminal domain interface [polypeptide binding]; other site 585055004967 putative active site [active] 585055004968 putative MgATP binding site [chemical binding]; other site 585055004969 catalytic site [active] 585055004970 metal binding site [ion binding]; metal-binding site 585055004971 putative carbohydrate binding site [chemical binding]; other site 585055004972 transcriptional regulator LsrR; Provisional; Region: PRK15418 585055004973 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585055004974 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585055004975 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 585055004976 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055004977 Walker A/P-loop; other site 585055004978 ATP binding site [chemical binding]; other site 585055004979 Q-loop/lid; other site 585055004980 ABC transporter signature motif; other site 585055004981 Walker B; other site 585055004982 D-loop; other site 585055004983 H-loop/switch region; other site 585055004984 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055004985 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055004986 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055004987 TM-ABC transporter signature motif; other site 585055004988 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055004989 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055004990 TM-ABC transporter signature motif; other site 585055004991 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 585055004992 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 585055004993 ligand binding site [chemical binding]; other site 585055004994 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 585055004995 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585055004996 putative active site; other site 585055004997 catalytic residue [active] 585055004998 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 585055004999 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 585055005000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055005001 S-adenosylmethionine binding site [chemical binding]; other site 585055005002 Predicted membrane protein [Function unknown]; Region: COG3781 585055005003 altronate oxidoreductase; Provisional; Region: PRK03643 585055005004 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585055005005 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585055005006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055005007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055005008 metal binding site [ion binding]; metal-binding site 585055005009 active site 585055005010 I-site; other site 585055005011 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 585055005012 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585055005013 glutaminase; Provisional; Region: PRK00971 585055005014 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 585055005015 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 585055005016 NAD(P) binding site [chemical binding]; other site 585055005017 catalytic residues [active] 585055005018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055005019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055005020 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 585055005021 putative dimerization interface [polypeptide binding]; other site 585055005022 fragment of conserved hypothetical protein (part 1);Evidence 7 : Gene remnant 585055005023 fragment of conserved hypothetical protein (part 2);Evidence 7 : Gene remnant 585055005024 fragment of conserved hypothetical protein (part 3);Evidence 7 : Gene remnant 585055005025 putative arabinose transporter; Provisional; Region: PRK03545 585055005026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005027 putative substrate translocation pore; other site 585055005028 inner membrane protein; Provisional; Region: PRK10995 585055005029 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 585055005030 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585055005031 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 585055005032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055005033 hypothetical protein; Provisional; Region: PRK10106 585055005034 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 585055005035 beta-galactosidase; Region: BGL; TIGR03356 585055005036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 585055005037 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585055005038 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585055005039 trimer interface; other site 585055005040 sugar binding site [chemical binding]; other site 585055005041 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585055005042 active site 585055005043 methionine cluster; other site 585055005044 phosphorylation site [posttranslational modification] 585055005045 metal binding site [ion binding]; metal-binding site 585055005046 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 585055005047 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585055005048 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585055005049 active site 585055005050 P-loop; other site 585055005051 phosphorylation site [posttranslational modification] 585055005052 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585055005053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055005054 DNA-binding site [nucleotide binding]; DNA binding site 585055005055 UTRA domain; Region: UTRA; pfam07702 585055005056 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 585055005057 EamA-like transporter family; Region: EamA; pfam00892 585055005058 EamA-like transporter family; Region: EamA; pfam00892 585055005059 putative transporter; Provisional; Region: PRK10054 585055005060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005061 putative substrate translocation pore; other site 585055005062 diguanylate cyclase; Provisional; Region: PRK09894 585055005063 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 585055005064 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055005065 metal binding site [ion binding]; metal-binding site 585055005066 active site 585055005067 I-site; other site 585055005068 hypothetical protein; Provisional; Region: PRK10053 585055005069 hypothetical protein; Validated; Region: PRK03657 585055005070 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 585055005071 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585055005072 active site 585055005073 Zn binding site [ion binding]; other site 585055005074 malonic semialdehyde reductase; Provisional; Region: PRK10538 585055005075 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 585055005076 putative NAD(P) binding site [chemical binding]; other site 585055005077 homodimer interface [polypeptide binding]; other site 585055005078 homotetramer interface [polypeptide binding]; other site 585055005079 active site 585055005080 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585055005081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055005082 DNA-binding site [nucleotide binding]; DNA binding site 585055005083 FCD domain; Region: FCD; pfam07729 585055005084 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 585055005085 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585055005086 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585055005087 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585055005088 metabolite-proton symporter; Region: 2A0106; TIGR00883 585055005089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005090 putative substrate translocation pore; other site 585055005091 General stress protein [General function prediction only]; Region: GsiB; COG3729 585055005092 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 585055005093 dimerization interface [polypeptide binding]; other site 585055005094 metal binding site [ion binding]; metal-binding site 585055005095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 585055005096 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 585055005097 dimanganese center [ion binding]; other site 585055005098 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585055005099 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585055005100 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585055005101 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585055005102 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585055005103 Phage Tail Collar Domain; Region: Collar; pfam07484 585055005104 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585055005105 Phage-related protein, tail component [Function unknown]; Region: COG4733 585055005106 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585055005107 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585055005108 Fibronectin type III protein; Region: DUF3672; pfam12421 585055005109 Phage-related protein, tail component [Function unknown]; Region: COG4723 585055005110 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585055005111 MPN+ (JAMM) motif; other site 585055005112 Zinc-binding site [ion binding]; other site 585055005113 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585055005114 NlpC/P60 family; Region: NLPC_P60; cl17555 585055005115 Phage-related protein [Function unknown]; Region: gp18; COG4672 585055005116 Phage-related protein [Function unknown]; Region: COG4718 585055005117 Phage-related minor tail protein [Function unknown]; Region: COG5281 585055005118 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585055005119 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585055005120 Minor tail protein T; Region: Phage_tail_T; pfam06223 585055005121 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 585055005122 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585055005123 Bacterial Ig-like domain 2; Region: BID_2; smart00635 585055005124 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585055005125 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585055005126 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 585055005127 Uncharacterized conserved protein [Function unknown]; Region: COG5471 585055005128 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585055005129 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585055005130 oligomer interface [polypeptide binding]; other site 585055005131 active site residues [active] 585055005132 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585055005133 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585055005134 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585055005135 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585055005136 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 585055005137 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585055005138 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585055005139 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585055005140 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585055005141 catalytic residues [active] 585055005142 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055005143 Lysis protein S; Region: Lysis_S; pfam04971 585055005144 TolA C-terminal; Region: TolA; pfam06519 585055005145 TolA protein; Region: tolA_full; TIGR02794 585055005146 TolA C-terminal; Region: TolA; pfam06519 585055005147 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585055005148 fragment of protein (partial);Evidence 7 : Gene remnant 585055005149 Antitermination protein; Region: Antiterm; pfam03589 585055005150 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585055005151 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585055005152 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585055005153 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585055005154 primosomal protein DnaI; Provisional; Region: PRK02854 585055005155 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585055005156 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585055005157 transcriptional repressor DicA; Reviewed; Region: PRK09706 585055005158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055005159 non-specific DNA binding site [nucleotide binding]; other site 585055005160 salt bridge; other site 585055005161 sequence-specific DNA binding site [nucleotide binding]; other site 585055005162 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585055005163 DicB protein; Region: DicB; pfam05358 585055005164 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585055005165 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585055005166 active site 585055005167 catalytic site [active] 585055005168 substrate binding site [chemical binding]; other site 585055005169 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 585055005170 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585055005171 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585055005172 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585055005173 Int/Topo IB signature motif; other site 585055005174 fragment of oxidoreductase, Zn-dependent and NAD(P)-binding (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055005175 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055005176 fragment of oxidoreductase, Zn-dependent and NAD(P)-binding (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055005177 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585055005178 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585055005179 putative active site pocket [active] 585055005180 putative metal binding site [ion binding]; other site 585055005181 hypothetical protein; Provisional; Region: PRK02237 585055005182 hypothetical protein; Provisional; Region: PRK13659 585055005183 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 585055005184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055005185 Coenzyme A binding pocket [chemical binding]; other site 585055005186 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 585055005187 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 585055005188 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585055005189 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585055005190 putative [Fe4-S4] binding site [ion binding]; other site 585055005191 putative molybdopterin cofactor binding site [chemical binding]; other site 585055005192 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585055005193 putative molybdopterin cofactor binding site; other site 585055005194 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585055005195 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585055005196 putative [Fe4-S4] binding site [ion binding]; other site 585055005197 putative molybdopterin cofactor binding site [chemical binding]; other site 585055005198 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585055005199 putative molybdopterin cofactor binding site; other site 585055005200 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585055005201 4Fe-4S binding domain; Region: Fer4; cl02805 585055005202 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585055005203 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 585055005204 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585055005205 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585055005206 Cl- selectivity filter; other site 585055005207 Cl- binding residues [ion binding]; other site 585055005208 pore gating glutamate residue; other site 585055005209 dimer interface [polypeptide binding]; other site 585055005210 putative dithiobiotin synthetase; Provisional; Region: PRK12374 585055005211 AAA domain; Region: AAA_26; pfam13500 585055005212 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585055005213 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585055005214 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055005215 nucleotide binding site [chemical binding]; other site 585055005216 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585055005217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055005218 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 585055005219 dimerization interface [polypeptide binding]; other site 585055005220 substrate binding pocket [chemical binding]; other site 585055005221 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585055005222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005223 putative substrate translocation pore; other site 585055005224 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 585055005225 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 585055005226 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 585055005227 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 585055005228 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585055005229 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 585055005230 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 585055005231 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 585055005232 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 585055005233 ligand binding site [chemical binding]; other site 585055005234 homodimer interface [polypeptide binding]; other site 585055005235 NAD(P) binding site [chemical binding]; other site 585055005236 trimer interface B [polypeptide binding]; other site 585055005237 trimer interface A [polypeptide binding]; other site 585055005238 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 585055005239 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055005240 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055005241 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055005242 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 585055005243 Spore germination protein; Region: Spore_permease; cl17796 585055005244 dihydromonapterin reductase; Provisional; Region: PRK06483 585055005245 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 585055005246 NADP binding site [chemical binding]; other site 585055005247 substrate binding pocket [chemical binding]; other site 585055005248 active site 585055005249 GlpM protein; Region: GlpM; pfam06942 585055005250 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 585055005251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055005252 active site 585055005253 phosphorylation site [posttranslational modification] 585055005254 intermolecular recognition site; other site 585055005255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055005256 DNA binding site [nucleotide binding] 585055005257 sensor protein RstB; Provisional; Region: PRK10604 585055005258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055005259 dimerization interface [polypeptide binding]; other site 585055005260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055005261 dimer interface [polypeptide binding]; other site 585055005262 phosphorylation site [posttranslational modification] 585055005263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055005264 ATP binding site [chemical binding]; other site 585055005265 Mg2+ binding site [ion binding]; other site 585055005266 G-X-G motif; other site 585055005267 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 585055005268 fumarate hydratase; Reviewed; Region: fumC; PRK00485 585055005269 Class II fumarases; Region: Fumarase_classII; cd01362 585055005270 active site 585055005271 tetramer interface [polypeptide binding]; other site 585055005272 fumarate hydratase; Provisional; Region: PRK15389 585055005273 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585055005274 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585055005275 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 585055005276 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 585055005277 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 585055005278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585055005279 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 585055005280 putative outer membrane porin protein; Provisional; Region: PRK11379 585055005281 glucuronide transporter; Provisional; Region: PRK09848 585055005282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005283 putative substrate translocation pore; other site 585055005284 beta-D-glucuronidase; Provisional; Region: PRK10150 585055005285 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585055005286 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585055005287 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585055005288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585055005289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055005290 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 585055005291 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 585055005292 NAD binding site [chemical binding]; other site 585055005293 substrate binding site [chemical binding]; other site 585055005294 homotetramer interface [polypeptide binding]; other site 585055005295 homodimer interface [polypeptide binding]; other site 585055005296 active site 585055005297 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 585055005298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055005299 DNA binding site [nucleotide binding] 585055005300 domain linker motif; other site 585055005301 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 585055005302 putative dimerization interface [polypeptide binding]; other site 585055005303 putative ligand binding site [chemical binding]; other site 585055005304 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 585055005305 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585055005306 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055005307 active site turn [active] 585055005308 phosphorylation site [posttranslational modification] 585055005309 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 585055005310 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055005311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055005312 homodimer interface [polypeptide binding]; other site 585055005313 catalytic residue [active] 585055005314 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 585055005315 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 585055005316 active site 585055005317 purine riboside binding site [chemical binding]; other site 585055005318 putative oxidoreductase; Provisional; Region: PRK11579 585055005319 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585055005320 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585055005321 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 585055005322 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 585055005323 electron transport complex protein RsxA; Provisional; Region: PRK05151 585055005324 electron transport complex protein RnfB; Provisional; Region: PRK05113 585055005325 Putative Fe-S cluster; Region: FeS; pfam04060 585055005326 4Fe-4S binding domain; Region: Fer4; pfam00037 585055005327 electron transport complex protein RnfC; Provisional; Region: PRK05035 585055005328 SLBB domain; Region: SLBB; pfam10531 585055005329 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055005330 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 585055005331 electron transport complex protein RnfG; Validated; Region: PRK01908 585055005332 electron transport complex RsxE subunit; Provisional; Region: PRK12405 585055005333 endonuclease III; Provisional; Region: PRK10702 585055005334 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585055005335 minor groove reading motif; other site 585055005336 helix-hairpin-helix signature motif; other site 585055005337 substrate binding pocket [chemical binding]; other site 585055005338 active site 585055005339 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 585055005340 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585055005341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005342 putative substrate translocation pore; other site 585055005343 POT family; Region: PTR2; pfam00854 585055005344 glutathionine S-transferase; Provisional; Region: PRK10542 585055005345 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585055005346 C-terminal domain interface [polypeptide binding]; other site 585055005347 GSH binding site (G-site) [chemical binding]; other site 585055005348 dimer interface [polypeptide binding]; other site 585055005349 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585055005350 N-terminal domain interface [polypeptide binding]; other site 585055005351 dimer interface [polypeptide binding]; other site 585055005352 substrate binding pocket (H-site) [chemical binding]; other site 585055005353 pyridoxamine kinase; Validated; Region: PRK05756 585055005354 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585055005355 dimer interface [polypeptide binding]; other site 585055005356 pyridoxal binding site [chemical binding]; other site 585055005357 ATP binding site [chemical binding]; other site 585055005358 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 585055005359 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 585055005360 active site 585055005361 HIGH motif; other site 585055005362 dimer interface [polypeptide binding]; other site 585055005363 KMSKS motif; other site 585055005364 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055005365 RNA binding surface [nucleotide binding]; other site 585055005366 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 585055005367 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 585055005368 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 585055005369 lysozyme inhibitor; Provisional; Region: PRK11372 585055005370 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 585055005371 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 585055005372 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 585055005373 transcriptional regulator SlyA; Provisional; Region: PRK03573 585055005374 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 585055005375 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 585055005376 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585055005377 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055005378 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055005379 Fusaric acid resistance protein family; Region: FUSC; pfam04632 585055005380 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585055005381 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585055005382 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585055005383 E-class dimer interface [polypeptide binding]; other site 585055005384 P-class dimer interface [polypeptide binding]; other site 585055005385 active site 585055005386 Cu2+ binding site [ion binding]; other site 585055005387 Zn2+ binding site [ion binding]; other site 585055005388 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055005389 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055005390 active site 585055005391 catalytic tetrad [active] 585055005392 Predicted Fe-S protein [General function prediction only]; Region: COG3313 585055005393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585055005394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055005395 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585055005396 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 585055005397 FMN binding site [chemical binding]; other site 585055005398 active site 585055005399 substrate binding site [chemical binding]; other site 585055005400 catalytic residue [active] 585055005401 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585055005402 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 585055005403 dimer interface [polypeptide binding]; other site 585055005404 active site 585055005405 metal binding site [ion binding]; metal-binding site 585055005406 glutathione binding site [chemical binding]; other site 585055005407 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 585055005408 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 585055005409 dimer interface [polypeptide binding]; other site 585055005410 catalytic site [active] 585055005411 putative active site [active] 585055005412 putative substrate binding site [chemical binding]; other site 585055005413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055005414 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 585055005415 ATP binding site [chemical binding]; other site 585055005416 putative Mg++ binding site [ion binding]; other site 585055005417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055005418 nucleotide binding region [chemical binding]; other site 585055005419 ATP-binding site [chemical binding]; other site 585055005420 DEAD/H associated; Region: DEAD_assoc; pfam08494 585055005421 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 585055005422 putative GSH binding site [chemical binding]; other site 585055005423 catalytic residues [active] 585055005424 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585055005425 NlpC/P60 family; Region: NLPC_P60; pfam00877 585055005426 superoxide dismutase; Provisional; Region: PRK10543 585055005427 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585055005428 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585055005429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055005431 putative substrate translocation pore; other site 585055005432 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 585055005433 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055005434 DNA binding site [nucleotide binding] 585055005435 domain linker motif; other site 585055005436 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585055005437 dimerization interface [polypeptide binding]; other site 585055005438 ligand binding site [chemical binding]; other site 585055005439 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585055005440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055005441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055005442 dimerization interface [polypeptide binding]; other site 585055005443 putative transporter; Provisional; Region: PRK11043 585055005444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005445 putative substrate translocation pore; other site 585055005446 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 585055005447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585055005448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055005449 S-adenosylmethionine binding site [chemical binding]; other site 585055005450 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 585055005451 Lumazine binding domain; Region: Lum_binding; pfam00677 585055005452 Lumazine binding domain; Region: Lum_binding; pfam00677 585055005453 multidrug efflux protein; Reviewed; Region: PRK01766 585055005454 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 585055005455 cation binding site [ion binding]; other site 585055005456 hypothetical protein; Provisional; Region: PRK09945 585055005457 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585055005458 putative monooxygenase; Provisional; Region: PRK11118 585055005459 hypothetical protein; Provisional; Region: PRK09897 585055005460 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 585055005461 hypothetical protein; Provisional; Region: PRK09946 585055005462 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 585055005463 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 585055005464 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585055005465 hypothetical protein; Provisional; Region: PRK09947 585055005466 putative oxidoreductase; Provisional; Region: PRK09849 585055005467 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 585055005468 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 585055005469 hypothetical protein; Provisional; Region: PRK09898 585055005470 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055005471 hypothetical protein; Provisional; Region: PRK10292 585055005472 pyruvate kinase; Provisional; Region: PRK09206 585055005473 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585055005474 domain interfaces; other site 585055005475 active site 585055005476 murein lipoprotein; Provisional; Region: PRK15396 585055005477 L,D-transpeptidase; Provisional; Region: PRK10190 585055005478 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055005479 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585055005480 cysteine desufuration protein SufE; Provisional; Region: PRK09296 585055005481 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585055005482 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585055005483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585055005484 catalytic residue [active] 585055005485 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 585055005486 FeS assembly protein SufD; Region: sufD; TIGR01981 585055005487 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 585055005488 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 585055005489 Walker A/P-loop; other site 585055005490 ATP binding site [chemical binding]; other site 585055005491 Q-loop/lid; other site 585055005492 ABC transporter signature motif; other site 585055005493 Walker B; other site 585055005494 D-loop; other site 585055005495 H-loop/switch region; other site 585055005496 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 585055005497 putative ABC transporter; Region: ycf24; CHL00085 585055005498 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 585055005499 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585055005500 CoenzymeA binding site [chemical binding]; other site 585055005501 subunit interaction site [polypeptide binding]; other site 585055005502 PHB binding site; other site 585055005503 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585055005504 FAD binding domain; Region: FAD_binding_4; pfam01565 585055005505 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585055005506 putative inner membrane protein; Provisional; Region: PRK10983 585055005507 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585055005508 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 585055005509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055005511 putative substrate translocation pore; other site 585055005512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005513 putative substrate translocation pore; other site 585055005514 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 585055005515 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585055005516 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585055005517 shikimate binding site; other site 585055005518 NAD(P) binding site [chemical binding]; other site 585055005519 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 585055005520 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 585055005521 active site 585055005522 catalytic residue [active] 585055005523 dimer interface [polypeptide binding]; other site 585055005524 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 585055005525 Coenzyme A transferase; Region: CoA_trans; smart00882 585055005526 Coenzyme A transferase; Region: CoA_trans; cl17247 585055005527 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 585055005528 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585055005529 active site 585055005530 Cupin domain; Region: Cupin_2; pfam07883 585055005531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055005532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055005533 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585055005534 Ligand binding site [chemical binding]; other site 585055005535 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585055005536 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 585055005537 Electron transfer flavoprotein domain; Region: ETF; smart00893 585055005538 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585055005539 oxidoreductase; Provisional; Region: PRK10015 585055005540 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585055005541 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 585055005542 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 585055005543 acyl-activating enzyme (AAE) consensus motif; other site 585055005544 putative AMP binding site [chemical binding]; other site 585055005545 putative active site [active] 585055005546 putative CoA binding site [chemical binding]; other site 585055005547 phosphoenolpyruvate synthase; Validated; Region: PRK06464 585055005548 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 585055005549 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585055005550 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585055005551 PEP synthetase regulatory protein; Provisional; Region: PRK05339 585055005552 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 585055005553 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585055005554 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 585055005555 Uncharacterized conserved protein [Function unknown]; Region: COG0397 585055005556 hypothetical protein; Validated; Region: PRK00029 585055005557 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 585055005558 NlpC/P60 family; Region: NLPC_P60; pfam00877 585055005559 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 585055005560 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585055005561 Walker A/P-loop; other site 585055005562 ATP binding site [chemical binding]; other site 585055005563 Q-loop/lid; other site 585055005564 ABC transporter signature motif; other site 585055005565 Walker B; other site 585055005566 D-loop; other site 585055005567 H-loop/switch region; other site 585055005568 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 585055005569 catalytic residues [active] 585055005570 dimer interface [polypeptide binding]; other site 585055005571 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585055005572 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055005573 ABC-ATPase subunit interface; other site 585055005574 dimer interface [polypeptide binding]; other site 585055005575 putative PBP binding regions; other site 585055005576 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585055005577 IHF dimer interface [polypeptide binding]; other site 585055005578 IHF - DNA interface [nucleotide binding]; other site 585055005579 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 585055005580 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 585055005581 putative tRNA-binding site [nucleotide binding]; other site 585055005582 B3/4 domain; Region: B3_4; pfam03483 585055005583 tRNA synthetase B5 domain; Region: B5; smart00874 585055005584 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 585055005585 dimer interface [polypeptide binding]; other site 585055005586 motif 1; other site 585055005587 motif 3; other site 585055005588 motif 2; other site 585055005589 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 585055005590 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 585055005591 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 585055005592 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 585055005593 dimer interface [polypeptide binding]; other site 585055005594 motif 1; other site 585055005595 active site 585055005596 motif 2; other site 585055005597 motif 3; other site 585055005598 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 585055005599 23S rRNA binding site [nucleotide binding]; other site 585055005600 L21 binding site [polypeptide binding]; other site 585055005601 L13 binding site [polypeptide binding]; other site 585055005602 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 585055005603 fragment of protein chain initiation factor IF-3 (partial);Evidence 7 : Gene remnant; Product type f : factor 585055005604 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 585055005605 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 585055005606 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 585055005607 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 585055005608 active site 585055005609 dimer interface [polypeptide binding]; other site 585055005610 motif 1; other site 585055005611 motif 2; other site 585055005612 motif 3; other site 585055005613 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 585055005614 anticodon binding site; other site 585055005615 fragment of ankyrin repeat regulatory protein (part 1);Evidence 7 : Gene remnant; Product type pr : regulator 585055005616 fragment of ankyrin repeat regulatory protein (part 2);Evidence 7 : Gene remnant; Product type pr : regulator 585055005617 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 585055005618 6-phosphofructokinase 2; Provisional; Region: PRK10294 585055005619 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585055005620 putative substrate binding site [chemical binding]; other site 585055005621 putative ATP binding site [chemical binding]; other site 585055005622 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585055005623 Phosphotransferase enzyme family; Region: APH; pfam01636 585055005624 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585055005625 active site 585055005626 ATP binding site [chemical binding]; other site 585055005627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 585055005628 YniB-like protein; Region: YniB; pfam14002 585055005629 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 585055005630 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585055005631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055005632 motif II; other site 585055005633 inner membrane protein; Provisional; Region: PRK11648 585055005634 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 585055005635 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585055005636 fragment of conserved hypothetical protein (part 2);Evidence 7 : Gene remnant 585055005637 fragment of conserved hypothetical protein (part 1);Evidence 7 : Gene remnant 585055005638 cell division modulator; Provisional; Region: PRK10113 585055005639 hydroperoxidase II; Provisional; Region: katE; PRK11249 585055005640 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 585055005641 tetramer interface [polypeptide binding]; other site 585055005642 heme binding pocket [chemical binding]; other site 585055005643 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 585055005644 domain interactions; other site 585055005645 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 585055005646 putative active site [active] 585055005647 YdjC motif; other site 585055005648 Mg binding site [ion binding]; other site 585055005649 putative homodimer interface [polypeptide binding]; other site 585055005650 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 585055005651 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 585055005652 NAD binding site [chemical binding]; other site 585055005653 sugar binding site [chemical binding]; other site 585055005654 divalent metal binding site [ion binding]; other site 585055005655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585055005656 dimer interface [polypeptide binding]; other site 585055005657 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 585055005658 Cupin domain; Region: Cupin_2; pfam07883 585055005659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055005660 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585055005661 methionine cluster; other site 585055005662 active site 585055005663 phosphorylation site [posttranslational modification] 585055005664 metal binding site [ion binding]; metal-binding site 585055005665 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 585055005666 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 585055005667 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585055005668 active site 585055005669 P-loop; other site 585055005670 phosphorylation site [posttranslational modification] 585055005671 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 585055005672 NAD+ synthetase; Region: nadE; TIGR00552 585055005673 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 585055005674 homodimer interface [polypeptide binding]; other site 585055005675 NAD binding pocket [chemical binding]; other site 585055005676 ATP binding pocket [chemical binding]; other site 585055005677 Mg binding site [ion binding]; other site 585055005678 active-site loop [active] 585055005679 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 585055005680 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585055005681 GIY-YIG motif/motif A; other site 585055005682 active site 585055005683 catalytic site [active] 585055005684 putative DNA binding site [nucleotide binding]; other site 585055005685 metal binding site [ion binding]; metal-binding site 585055005686 hypothetical protein; Provisional; Region: PRK11396 585055005687 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585055005688 dimer interface [polypeptide binding]; other site 585055005689 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 585055005690 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 585055005691 putative active site [active] 585055005692 Zn binding site [ion binding]; other site 585055005693 succinylarginine dihydrolase; Provisional; Region: PRK13281 585055005694 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 585055005695 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 585055005696 NAD(P) binding site [chemical binding]; other site 585055005697 catalytic residues [active] 585055005698 arginine succinyltransferase; Provisional; Region: PRK10456 585055005699 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 585055005700 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 585055005701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585055005702 inhibitor-cofactor binding pocket; inhibition site 585055005703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055005704 catalytic residue [active] 585055005705 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 585055005706 putative catalytic site [active] 585055005707 putative phosphate binding site [ion binding]; other site 585055005708 active site 585055005709 metal binding site A [ion binding]; metal-binding site 585055005710 DNA binding site [nucleotide binding] 585055005711 putative AP binding site [nucleotide binding]; other site 585055005712 putative metal binding site B [ion binding]; other site 585055005713 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585055005714 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585055005715 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585055005716 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585055005717 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585055005718 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 585055005719 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 585055005720 hypothetical protein; Provisional; Region: PRK11622 585055005721 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 585055005722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055005723 ABC-ATPase subunit interface; other site 585055005724 putative PBP binding loops; other site 585055005725 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 585055005726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055005727 Walker A/P-loop; other site 585055005728 ATP binding site [chemical binding]; other site 585055005729 Q-loop/lid; other site 585055005730 ABC transporter signature motif; other site 585055005731 Walker B; other site 585055005732 D-loop; other site 585055005733 H-loop/switch region; other site 585055005734 Rhodanese Homology Domain; Region: RHOD; smart00450 585055005735 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 585055005736 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585055005737 active site residue [active] 585055005738 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585055005739 active site residue [active] 585055005740 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585055005741 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585055005742 active site 585055005743 8-oxo-dGMP binding site [chemical binding]; other site 585055005744 nudix motif; other site 585055005745 metal binding site [ion binding]; metal-binding site 585055005746 glutamate dehydrogenase; Provisional; Region: PRK09414 585055005747 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 585055005748 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 585055005749 NAD(P) binding site [chemical binding]; other site 585055005750 hypothetical protein; Provisional; Region: PRK11380 585055005751 DNA topoisomerase III; Provisional; Region: PRK07726 585055005752 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 585055005753 active site 585055005754 putative interdomain interaction site [polypeptide binding]; other site 585055005755 putative metal-binding site [ion binding]; other site 585055005756 putative nucleotide binding site [chemical binding]; other site 585055005757 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585055005758 domain I; other site 585055005759 DNA binding groove [nucleotide binding] 585055005760 phosphate binding site [ion binding]; other site 585055005761 domain II; other site 585055005762 domain III; other site 585055005763 nucleotide binding site [chemical binding]; other site 585055005764 catalytic site [active] 585055005765 domain IV; other site 585055005766 selenophosphate synthetase; Provisional; Region: PRK00943 585055005767 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 585055005768 dimerization interface [polypeptide binding]; other site 585055005769 putative ATP binding site [chemical binding]; other site 585055005770 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 585055005771 putative FMN binding site [chemical binding]; other site 585055005772 protease 4; Provisional; Region: PRK10949 585055005773 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 585055005774 tandem repeat interface [polypeptide binding]; other site 585055005775 oligomer interface [polypeptide binding]; other site 585055005776 active site residues [active] 585055005777 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 585055005778 tandem repeat interface [polypeptide binding]; other site 585055005779 oligomer interface [polypeptide binding]; other site 585055005780 active site residues [active] 585055005781 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 585055005782 active site 585055005783 homodimer interface [polypeptide binding]; other site 585055005784 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 585055005785 Isochorismatase family; Region: Isochorismatase; pfam00857 585055005786 catalytic triad [active] 585055005787 metal binding site [ion binding]; metal-binding site 585055005788 conserved cis-peptide bond; other site 585055005789 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 585055005790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005791 putative substrate translocation pore; other site 585055005792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005793 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585055005794 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585055005795 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055005796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055005797 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055005798 active site 585055005799 catalytic tetrad [active] 585055005800 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055005801 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585055005802 substrate binding site [chemical binding]; other site 585055005803 ATP binding site [chemical binding]; other site 585055005804 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585055005805 intersubunit interface [polypeptide binding]; other site 585055005806 active site 585055005807 zinc binding site [ion binding]; other site 585055005808 Na+ binding site [ion binding]; other site 585055005809 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585055005810 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 585055005811 inhibitor binding site; inhibition site 585055005812 catalytic Zn binding site [ion binding]; other site 585055005813 structural Zn binding site [ion binding]; other site 585055005814 NADP binding site [chemical binding]; other site 585055005815 tetramer interface [polypeptide binding]; other site 585055005816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005818 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585055005819 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 585055005820 putative NAD(P) binding site [chemical binding]; other site 585055005821 catalytic Zn binding site [ion binding]; other site 585055005822 structural Zn binding site [ion binding]; other site 585055005823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 585055005824 methionine sulfoxide reductase B; Provisional; Region: PRK00222 585055005825 SelR domain; Region: SelR; pfam01641 585055005826 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 585055005827 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585055005828 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585055005829 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 585055005830 active site 585055005831 phosphate binding residues; other site 585055005832 catalytic residues [active] 585055005833 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055005834 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055005835 active site 585055005836 catalytic tetrad [active] 585055005837 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585055005838 PrkA family serine protein kinase; Provisional; Region: PRK15455 585055005839 AAA ATPase domain; Region: AAA_16; pfam13191 585055005840 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 585055005841 hypothetical protein; Provisional; Region: PRK05325 585055005842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055005843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055005844 metal binding site [ion binding]; metal-binding site 585055005845 active site 585055005846 I-site; other site 585055005847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055005848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055005849 metal binding site [ion binding]; metal-binding site 585055005850 active site 585055005851 I-site; other site 585055005852 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 585055005853 putative deacylase active site [active] 585055005854 Predicted membrane protein [Function unknown]; Region: COG2707 585055005855 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055005856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055005857 cyanate transporter; Region: CynX; TIGR00896 585055005858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005859 putative substrate translocation pore; other site 585055005860 Uncharacterized conserved protein [Function unknown]; Region: COG3189 585055005861 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585055005862 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585055005863 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 585055005864 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585055005865 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055005866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055005867 metal binding site [ion binding]; metal-binding site 585055005868 active site 585055005869 I-site; other site 585055005870 hypothetical protein; Provisional; Region: PRK10457 585055005871 Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]; Region: CRM1; COG5101 585055005872 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585055005873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 585055005874 Probable transposase; Region: OrfB_IS605; pfam01385 585055005875 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585055005876 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 585055005877 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 585055005878 leucine export protein LeuE; Provisional; Region: PRK10958 585055005879 transcriptional activator TtdR; Provisional; Region: PRK09801 585055005880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055005881 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 585055005882 putative effector binding pocket; other site 585055005883 putative dimerization interface [polypeptide binding]; other site 585055005884 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 585055005885 tartrate dehydrogenase; Region: TTC; TIGR02089 585055005886 putative transporter; Provisional; Region: PRK09950 585055005887 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 585055005888 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 585055005889 [2Fe-2S] cluster binding site [ion binding]; other site 585055005890 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 585055005891 putative alpha subunit interface [polypeptide binding]; other site 585055005892 putative active site [active] 585055005893 putative substrate binding site [chemical binding]; other site 585055005894 Fe binding site [ion binding]; other site 585055005895 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 585055005896 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 585055005897 FMN-binding pocket [chemical binding]; other site 585055005898 flavin binding motif; other site 585055005899 phosphate binding motif [ion binding]; other site 585055005900 beta-alpha-beta structure motif; other site 585055005901 NAD binding pocket [chemical binding]; other site 585055005902 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055005903 catalytic loop [active] 585055005904 iron binding site [ion binding]; other site 585055005905 ribonuclease D; Provisional; Region: PRK10829 585055005906 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 585055005907 catalytic site [active] 585055005908 putative active site [active] 585055005909 putative substrate binding site [chemical binding]; other site 585055005910 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585055005911 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 585055005912 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 585055005913 acyl-activating enzyme (AAE) consensus motif; other site 585055005914 putative AMP binding site [chemical binding]; other site 585055005915 putative active site [active] 585055005916 putative CoA binding site [chemical binding]; other site 585055005917 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 585055005918 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 585055005919 Glycoprotease family; Region: Peptidase_M22; pfam00814 585055005920 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 585055005921 DEAD/DEAH box helicase; Region: DEAD; pfam00270 585055005922 DEAD_2; Region: DEAD_2; pfam06733 585055005923 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585055005924 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 585055005925 homotrimer interaction site [polypeptide binding]; other site 585055005926 putative active site [active] 585055005927 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 585055005928 hypothetical protein; Provisional; Region: PRK05114 585055005929 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 585055005930 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585055005931 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 585055005932 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 585055005933 putative active site [active] 585055005934 putative CoA binding site [chemical binding]; other site 585055005935 nudix motif; other site 585055005936 metal binding site [ion binding]; metal-binding site 585055005937 L-serine deaminase; Provisional; Region: PRK15023 585055005938 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585055005939 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585055005940 phage resistance protein; Provisional; Region: PRK10551 585055005941 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585055005942 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055005943 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585055005944 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585055005945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585055005946 Transporter associated domain; Region: CorC_HlyC; smart01091 585055005947 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 585055005948 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585055005949 active pocket/dimerization site; other site 585055005950 active site 585055005951 phosphorylation site [posttranslational modification] 585055005952 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585055005953 active site 585055005954 phosphorylation site [posttranslational modification] 585055005955 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585055005956 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 585055005957 Predicted membrane protein [Function unknown]; Region: COG4811 585055005958 hypothetical protein; Provisional; Region: PRK11469 585055005959 Domain of unknown function DUF; Region: DUF204; pfam02659 585055005960 Domain of unknown function DUF; Region: DUF204; pfam02659 585055005961 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 585055005962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055005963 S-adenosylmethionine binding site [chemical binding]; other site 585055005964 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585055005965 DNA-binding site [nucleotide binding]; DNA binding site 585055005966 RNA-binding motif; other site 585055005967 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 585055005968 YebO-like protein; Region: YebO; pfam13974 585055005969 PhoPQ regulatory protein; Provisional; Region: PRK10299 585055005970 YobH-like protein; Region: YobH; pfam13996 585055005971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055005972 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055005973 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055005974 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055005975 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 585055005976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055005977 dimerization interface [polypeptide binding]; other site 585055005978 putative Zn2+ binding site [ion binding]; other site 585055005979 putative DNA binding site [nucleotide binding]; other site 585055005980 Bacterial transcriptional regulator; Region: IclR; pfam01614 585055005981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055005982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055005983 putative substrate translocation pore; other site 585055005984 Predicted integral membrane protein [Function unknown]; Region: COG5521 585055005985 heat shock protein HtpX; Provisional; Region: PRK05457 585055005986 carboxy-terminal protease; Provisional; Region: PRK11186 585055005987 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 585055005988 protein binding site [polypeptide binding]; other site 585055005989 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 585055005990 Catalytic dyad [active] 585055005991 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 585055005992 ProP expression regulator; Provisional; Region: PRK04950 585055005993 ProQ/FINO family; Region: ProQ; pfam04352 585055005994 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 585055005995 GAF domain; Region: GAF_2; pfam13185 585055005996 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 585055005997 Paraquat-inducible protein A; Region: PqiA; pfam04403 585055005998 Paraquat-inducible protein A; Region: PqiA; pfam04403 585055005999 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 585055006000 mce related protein; Region: MCE; pfam02470 585055006001 mce related protein; Region: MCE; pfam02470 585055006002 mce related protein; Region: MCE; pfam02470 585055006003 mce related protein; Region: MCE; pfam02470 585055006004 mce related protein; Region: MCE; pfam02470 585055006005 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 585055006006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055006007 S-adenosylmethionine binding site [chemical binding]; other site 585055006008 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 585055006009 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 585055006010 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585055006011 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585055006012 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585055006013 active site 585055006014 metal binding site [ion binding]; metal-binding site 585055006015 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055006016 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 585055006017 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 585055006018 hypothetical protein; Provisional; Region: PRK10301 585055006019 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 585055006020 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585055006021 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 585055006022 exodeoxyribonuclease X; Provisional; Region: PRK07983 585055006023 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585055006024 active site 585055006025 catalytic site [active] 585055006026 substrate binding site [chemical binding]; other site 585055006027 protease 2; Provisional; Region: PRK10115 585055006028 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585055006029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 585055006030 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 585055006031 putative metal binding site [ion binding]; other site 585055006032 hypothetical protein; Provisional; Region: PRK13680 585055006033 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 585055006034 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 585055006035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585055006036 ATP-grasp domain; Region: ATP-grasp; pfam02222 585055006037 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 585055006038 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585055006039 active site 585055006040 intersubunit interface [polypeptide binding]; other site 585055006041 catalytic residue [active] 585055006042 phosphogluconate dehydratase; Validated; Region: PRK09054 585055006043 6-phosphogluconate dehydratase; Region: edd; TIGR01196 585055006044 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 585055006045 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 585055006046 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 585055006047 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 585055006048 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585055006049 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585055006050 putative active site [active] 585055006051 pyruvate kinase; Provisional; Region: PRK05826 585055006052 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 585055006053 domain interfaces; other site 585055006054 active site 585055006055 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585055006056 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585055006057 putative acyl-acceptor binding pocket; other site 585055006058 putative peptidase; Provisional; Region: PRK11649 585055006059 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 585055006060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055006061 Peptidase family M23; Region: Peptidase_M23; pfam01551 585055006062 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 585055006063 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 585055006064 metal binding site [ion binding]; metal-binding site 585055006065 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 585055006066 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 585055006067 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585055006068 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055006069 ABC-ATPase subunit interface; other site 585055006070 dimer interface [polypeptide binding]; other site 585055006071 putative PBP binding regions; other site 585055006072 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 585055006073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055006074 Walker A motif; other site 585055006075 ATP binding site [chemical binding]; other site 585055006076 Walker B motif; other site 585055006077 arginine finger; other site 585055006078 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 585055006079 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 585055006080 RuvA N terminal domain; Region: RuvA_N; pfam01330 585055006081 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 585055006082 hypothetical protein; Provisional; Region: PRK11470 585055006083 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 585055006084 active site 585055006085 putative DNA-binding cleft [nucleotide binding]; other site 585055006086 dimer interface [polypeptide binding]; other site 585055006087 hypothetical protein; Validated; Region: PRK00110 585055006088 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 585055006089 nudix motif; other site 585055006090 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 585055006091 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 585055006092 dimer interface [polypeptide binding]; other site 585055006093 anticodon binding site; other site 585055006094 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585055006095 homodimer interface [polypeptide binding]; other site 585055006096 motif 1; other site 585055006097 active site 585055006098 motif 2; other site 585055006099 GAD domain; Region: GAD; pfam02938 585055006100 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585055006101 motif 3; other site 585055006102 Isochorismatase family; Region: Isochorismatase; pfam00857 585055006103 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585055006104 catalytic triad [active] 585055006105 conserved cis-peptide bond; other site 585055006106 hypothetical protein; Provisional; Region: PRK10302 585055006107 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 585055006108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055006109 S-adenosylmethionine binding site [chemical binding]; other site 585055006110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055006111 S-adenosylmethionine binding site [chemical binding]; other site 585055006112 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585055006113 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585055006114 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585055006115 molybdopterin cofactor binding site [chemical binding]; other site 585055006116 substrate binding site [chemical binding]; other site 585055006117 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585055006118 molybdopterin cofactor binding site; other site 585055006119 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 585055006120 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585055006121 copper homeostasis protein CutC; Provisional; Region: PRK11572 585055006122 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 585055006123 putative metal binding site [ion binding]; other site 585055006124 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 585055006125 arginyl-tRNA synthetase; Region: argS; TIGR00456 585055006126 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 585055006127 active site 585055006128 HIGH motif; other site 585055006129 KMSK motif region; other site 585055006130 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 585055006131 tRNA binding surface [nucleotide binding]; other site 585055006132 anticodon binding site; other site 585055006133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 585055006134 Flagellar protein FlhE; Region: FlhE; pfam06366 585055006135 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 585055006136 FHIPEP family; Region: FHIPEP; pfam00771 585055006137 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 585055006138 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 585055006139 chemotaxis regulator CheZ; Provisional; Region: PRK11166 585055006140 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 585055006141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055006142 active site 585055006143 phosphorylation site [posttranslational modification] 585055006144 intermolecular recognition site; other site 585055006145 dimerization interface [polypeptide binding]; other site 585055006146 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 585055006147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055006148 active site 585055006149 phosphorylation site [posttranslational modification] 585055006150 intermolecular recognition site; other site 585055006151 dimerization interface [polypeptide binding]; other site 585055006152 CheB methylesterase; Region: CheB_methylest; pfam01339 585055006153 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 585055006154 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 585055006155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055006156 S-adenosylmethionine binding site [chemical binding]; other site 585055006157 methyl-accepting protein IV; Provisional; Region: PRK09793 585055006158 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585055006159 dimer interface [polypeptide binding]; other site 585055006160 ligand binding site [chemical binding]; other site 585055006161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055006162 dimerization interface [polypeptide binding]; other site 585055006163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585055006164 dimer interface [polypeptide binding]; other site 585055006165 putative CheW interface [polypeptide binding]; other site 585055006166 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585055006167 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585055006168 dimer interface [polypeptide binding]; other site 585055006169 ligand binding site [chemical binding]; other site 585055006170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055006171 dimerization interface [polypeptide binding]; other site 585055006172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585055006173 dimer interface [polypeptide binding]; other site 585055006174 putative CheW interface [polypeptide binding]; other site 585055006175 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 585055006176 putative CheA interaction surface; other site 585055006177 chemotaxis protein CheA; Provisional; Region: PRK10547 585055006178 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585055006179 putative binding surface; other site 585055006180 active site 585055006181 CheY binding; Region: CheY-binding; pfam09078 585055006182 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 585055006183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055006184 ATP binding site [chemical binding]; other site 585055006185 Mg2+ binding site [ion binding]; other site 585055006186 G-X-G motif; other site 585055006187 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 585055006188 flagellar motor protein MotB; Validated; Region: motB; PRK09041 585055006189 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 585055006190 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585055006191 ligand binding site [chemical binding]; other site 585055006192 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 585055006193 flagellar motor protein MotA; Validated; Region: PRK09110 585055006194 transcriptional activator FlhC; Provisional; Region: PRK12722 585055006195 transcriptional activator FlhD; Provisional; Region: PRK02909 585055006196 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585055006197 Ligand Binding Site [chemical binding]; other site 585055006198 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 585055006199 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 585055006200 active site 585055006201 homotetramer interface [polypeptide binding]; other site 585055006202 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 585055006203 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 585055006204 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055006205 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055006206 TM-ABC transporter signature motif; other site 585055006207 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 585055006208 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055006209 Walker A/P-loop; other site 585055006210 ATP binding site [chemical binding]; other site 585055006211 Q-loop/lid; other site 585055006212 ABC transporter signature motif; other site 585055006213 Walker B; other site 585055006214 D-loop; other site 585055006215 H-loop/switch region; other site 585055006216 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055006217 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585055006218 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 585055006219 ligand binding site [chemical binding]; other site 585055006220 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585055006221 Ferritin-like domain; Region: Ferritin; pfam00210 585055006222 ferroxidase diiron center [ion binding]; other site 585055006223 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 585055006224 YecR-like lipoprotein; Region: YecR; pfam13992 585055006225 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585055006226 Ferritin-like domain; Region: Ferritin; pfam00210 585055006227 ferroxidase diiron center [ion binding]; other site 585055006228 probable metal-binding protein; Region: matur_matur; TIGR03853 585055006229 tyrosine transporter TyrP; Provisional; Region: PRK15132 585055006230 aromatic amino acid transport protein; Region: araaP; TIGR00837 585055006231 hypothetical protein; Provisional; Region: PRK10396 585055006232 yecA family protein; Region: ygfB_yecA; TIGR02292 585055006233 SEC-C motif; Region: SEC-C; pfam02810 585055006234 integrase; Provisional; Region: int; PHA02601 585055006235 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 585055006236 dimer interface [polypeptide binding]; other site 585055006237 active site 585055006238 catalytic residues [active] 585055006239 Int/Topo IB signature motif; other site 585055006240 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 585055006241 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 585055006242 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585055006243 putative DNA binding site [nucleotide binding]; other site 585055006244 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 585055006245 putative Zn2+ binding site [ion binding]; other site 585055006246 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 585055006247 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 585055006248 Mg binding site [ion binding]; other site 585055006249 nucleotide binding site [chemical binding]; other site 585055006250 putative protofilament interface [polypeptide binding]; other site 585055006251 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 585055006252 Phage-related protein [Function unknown]; Region: COG4695; cl01923 585055006253 Phage portal protein; Region: Phage_portal; pfam04860 585055006254 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 585055006255 terminase ATPase subunit; Provisional; Region: P; PHA02535 585055006256 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 585055006257 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 585055006258 terminase endonuclease subunit; Provisional; Region: M; PHA02537 585055006259 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 585055006260 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 585055006261 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 585055006262 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 585055006263 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 585055006264 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 585055006265 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 585055006266 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585055006267 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 585055006268 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 585055006269 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 585055006270 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 585055006271 Baseplate J-like protein; Region: Baseplate_J; cl01294 585055006272 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 585055006273 fragment of tail fiber protein (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055006274 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585055006275 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 585055006276 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585055006277 trimer interface [polypeptide binding]; other site 585055006278 active site 585055006279 substrate binding site [chemical binding]; other site 585055006280 CoA binding site [chemical binding]; other site 585055006281 Phage protein U [General function prediction only]; Region: COG3499 585055006282 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 585055006283 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 585055006284 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585055006285 Phage tail tube protein FII; Region: Phage_tube; cl01390 585055006286 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 585055006287 tail protein; Provisional; Region: D; PHA02561 585055006288 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 585055006289 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 585055006290 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585055006291 GIY-YIG motif/motif A; other site 585055006292 active site 585055006293 catalytic site [active] 585055006294 putative DNA binding site [nucleotide binding]; other site 585055006295 metal binding site [ion binding]; metal-binding site 585055006296 UvrB/uvrC motif; Region: UVR; pfam02151 585055006297 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 585055006298 Helix-hairpin-helix motif; Region: HHH; pfam00633 585055006299 response regulator; Provisional; Region: PRK09483 585055006300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055006301 active site 585055006302 phosphorylation site [posttranslational modification] 585055006303 intermolecular recognition site; other site 585055006304 dimerization interface [polypeptide binding]; other site 585055006305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055006306 DNA binding residues [nucleotide binding] 585055006307 dimerization interface [polypeptide binding]; other site 585055006308 hypothetical protein; Provisional; Region: PRK10613 585055006309 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 585055006310 Autoinducer binding domain; Region: Autoind_bind; pfam03472 585055006311 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055006312 DNA binding residues [nucleotide binding] 585055006313 dimerization interface [polypeptide binding]; other site 585055006314 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 585055006315 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585055006316 Walker A/P-loop; other site 585055006317 ATP binding site [chemical binding]; other site 585055006318 Q-loop/lid; other site 585055006319 ABC transporter signature motif; other site 585055006320 Walker B; other site 585055006321 D-loop; other site 585055006322 H-loop/switch region; other site 585055006323 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585055006324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055006325 dimer interface [polypeptide binding]; other site 585055006326 conserved gate region; other site 585055006327 putative PBP binding loops; other site 585055006328 ABC-ATPase subunit interface; other site 585055006329 D-cysteine desulfhydrase; Validated; Region: PRK03910 585055006330 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 585055006331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055006332 catalytic residue [active] 585055006333 cystine transporter subunit; Provisional; Region: PRK11260 585055006334 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055006335 substrate binding pocket [chemical binding]; other site 585055006336 membrane-bound complex binding site; other site 585055006337 hinge residues; other site 585055006338 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 585055006339 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 585055006340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585055006341 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585055006342 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585055006343 DNA binding residues [nucleotide binding] 585055006344 flagellin; Validated; Region: PRK06819 585055006345 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585055006346 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 585055006347 flagellar capping protein; Reviewed; Region: fliD; PRK08032 585055006348 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 585055006349 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 585055006350 Flagellar protein FliS; Region: FliS; cl00654 585055006351 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 585055006352 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 585055006353 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 585055006354 active site 585055006355 Na/Ca binding site [ion binding]; other site 585055006356 catalytic site [active] 585055006357 lipoprotein; Provisional; Region: PRK10397 585055006358 putative inner membrane protein; Provisional; Region: PRK11099 585055006359 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 585055006360 CPxP motif; other site 585055006361 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055006362 Transposase IS200 like; Region: Y1_Tnp; pfam01797 585055006363 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055006364 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585055006365 substrate binding site [chemical binding]; other site 585055006366 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 585055006367 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 585055006368 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 585055006369 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 585055006370 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 585055006371 flagellar motor switch protein FliG; Region: fliG; TIGR00207 585055006372 FliG C-terminal domain; Region: FliG_C; pfam01706 585055006373 flagellar assembly protein H; Validated; Region: fliH; PRK05687 585055006374 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 585055006375 Flagellar assembly protein FliH; Region: FliH; pfam02108 585055006376 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 585055006377 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 585055006378 Walker A motif/ATP binding site; other site 585055006379 Walker B motif; other site 585055006380 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 585055006381 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 585055006382 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 585055006383 flagellar hook-length control protein; Provisional; Region: PRK10118 585055006384 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 585055006385 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 585055006386 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 585055006387 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 585055006388 flagellar motor switch protein; Validated; Region: fliN; PRK05698 585055006389 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 585055006390 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 585055006391 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 585055006392 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 585055006393 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 585055006394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055006395 DNA binding residues [nucleotide binding] 585055006396 dimerization interface [polypeptide binding]; other site 585055006397 hypothetical protein; Provisional; Region: PRK10708 585055006398 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 585055006399 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 585055006400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055006401 active site 585055006402 motif I; other site 585055006403 motif II; other site 585055006404 fragment of diguanylate cyclase (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055006405 fragment of diguanylate cyclase (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055006406 Uncharacterized small protein [Function unknown]; Region: COG5475 585055006407 hypothetical protein; Provisional; Region: PRK10062 585055006408 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 585055006409 EamA-like transporter family; Region: EamA; pfam00892 585055006410 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 585055006411 additional DNA contacts [nucleotide binding]; other site 585055006412 mismatch recognition site; other site 585055006413 active site 585055006414 zinc binding site [ion binding]; other site 585055006415 DNA intercalation site [nucleotide binding]; other site 585055006416 DNA cytosine methylase; Provisional; Region: PRK10458 585055006417 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585055006418 cofactor binding site; other site 585055006419 DNA binding site [nucleotide binding] 585055006420 substrate interaction site [chemical binding]; other site 585055006421 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 585055006422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585055006423 Zn2+ binding site [ion binding]; other site 585055006424 Mg2+ binding site [ion binding]; other site 585055006425 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585055006426 fragment of outer membrane protein yedS precursor (part 1);Evidence 7 : Gene remnant; Product type pm : membrane component 585055006427 fragment of outer membrane protein yedS precursor (part 2);Evidence 7 : Gene remnant; Product type pm : membrane component 585055006428 fragment of transposase ORF A, IS600 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055006429 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 585055006430 Helix-turn-helix domain; Region: HTH_38; pfam13936 585055006431 Integrase core domain; Region: rve; pfam00665 585055006432 putative transposase OrfB; Reviewed; Region: PHA02517 585055006433 Integrase core domain; Region: rve; pfam00665 585055006434 Integrase core domain; Region: rve_3; pfam13683 585055006435 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055006436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055006437 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055006438 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055006439 chaperone protein HchA; Provisional; Region: PRK04155 585055006440 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 585055006441 dimer interface [polypeptide binding]; other site 585055006442 metal binding site [ion binding]; metal-binding site 585055006443 potential oxyanion hole; other site 585055006444 potential catalytic triad [active] 585055006445 conserved cys residue [active] 585055006446 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 585055006447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055006448 dimer interface [polypeptide binding]; other site 585055006449 phosphorylation site [posttranslational modification] 585055006450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055006451 ATP binding site [chemical binding]; other site 585055006452 Mg2+ binding site [ion binding]; other site 585055006453 G-X-G motif; other site 585055006454 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 585055006455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055006456 active site 585055006457 phosphorylation site [posttranslational modification] 585055006458 intermolecular recognition site; other site 585055006459 dimerization interface [polypeptide binding]; other site 585055006460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055006461 DNA binding site [nucleotide binding] 585055006462 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 585055006463 active site 585055006464 homotetramer interface [polypeptide binding]; other site 585055006465 TMAO/DMSO reductase; Reviewed; Region: PRK05363 585055006466 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 585055006467 Moco binding site; other site 585055006468 metal coordination site [ion binding]; other site 585055006469 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 585055006470 zinc/cadmium-binding protein; Provisional; Region: PRK10306 585055006471 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 585055006472 integrase; Provisional; Region: PRK09692 585055006473 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585055006474 active site 585055006475 Int/Topo IB signature motif; other site 585055006476 salicylate synthase Irp9; Reviewed; Region: PRK06772 585055006477 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585055006478 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 585055006479 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 585055006480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055006481 Walker A/P-loop; other site 585055006482 ATP binding site [chemical binding]; other site 585055006483 Q-loop/lid; other site 585055006484 ABC transporter signature motif; other site 585055006485 Walker B; other site 585055006486 D-loop; other site 585055006487 H-loop/switch region; other site 585055006488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585055006489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 585055006490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055006491 Walker A/P-loop; other site 585055006492 ATP binding site [chemical binding]; other site 585055006493 Q-loop/lid; other site 585055006494 ABC transporter signature motif; other site 585055006495 Walker B; other site 585055006496 D-loop; other site 585055006497 H-loop/switch region; other site 585055006498 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055006499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055006500 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 585055006501 Condensation domain; Region: Condensation; pfam00668 585055006502 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 585055006503 Nonribosomal peptide synthase; Region: NRPS; pfam08415 585055006504 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 585055006505 acyl-activating enzyme (AAE) consensus motif; other site 585055006506 AMP binding site [chemical binding]; other site 585055006507 Methyltransferase domain; Region: Methyltransf_23; pfam13489 585055006508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055006509 S-adenosylmethionine binding site [chemical binding]; other site 585055006510 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 585055006511 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585055006512 Condensation domain; Region: Condensation; pfam00668 585055006513 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 585055006514 Nonribosomal peptide synthase; Region: NRPS; pfam08415 585055006515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585055006516 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 585055006517 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 585055006518 active site 585055006519 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 585055006520 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 585055006521 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585055006522 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 585055006523 KR domain; Region: KR; pfam08659 585055006524 NADP binding site [chemical binding]; other site 585055006525 active site 585055006526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585055006527 Condensation domain; Region: Condensation; pfam00668 585055006528 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 585055006529 Nonribosomal peptide synthase; Region: NRPS; pfam08415 585055006530 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585055006531 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585055006532 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 585055006533 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 585055006534 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585055006535 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 585055006536 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 585055006537 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 585055006538 acyl-activating enzyme (AAE) consensus motif; other site 585055006539 active site 585055006540 AMP binding site [chemical binding]; other site 585055006541 substrate binding site [chemical binding]; other site 585055006542 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 585055006543 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055006544 N-terminal plug; other site 585055006545 ligand-binding site [chemical binding]; other site 585055006546 adhesin (part 1);Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor 585055006547 adhesin (part 2);Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor 585055006548 fragment of adhesin (part 1);Evidence 7 : Gene remnant; Product type f : factor 585055006549 fragment of adhesin (part 2);Evidence 7 : Gene remnant; Product type f : factor 585055006550 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585055006551 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585055006552 shikimate transporter; Provisional; Region: PRK09952 585055006553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055006554 putative substrate translocation pore; other site 585055006555 AMP nucleosidase; Provisional; Region: PRK08292 585055006556 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 585055006557 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 585055006558 hypothetical protein; Provisional; Region: PRK12378 585055006559 MATE family multidrug exporter; Provisional; Region: PRK10189 585055006560 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 585055006561 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 585055006562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055006563 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 585055006564 putative substrate binding site [chemical binding]; other site 585055006565 dimerization interface [polypeptide binding]; other site 585055006566 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 585055006567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055006568 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 585055006569 putative dimerization interface [polypeptide binding]; other site 585055006570 L,D-transpeptidase; Provisional; Region: PRK10190 585055006571 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585055006572 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 585055006573 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 585055006574 putative dimer interface [polypeptide binding]; other site 585055006575 active site pocket [active] 585055006576 putative cataytic base [active] 585055006577 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 585055006578 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 585055006579 homotrimer interface [polypeptide binding]; other site 585055006580 Walker A motif; other site 585055006581 GTP binding site [chemical binding]; other site 585055006582 Walker B motif; other site 585055006583 fragment of Cobalamin biosynthesis protein CbiG (partial);Evidence 7 : Gene remnant 585055006584 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585055006585 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585055006586 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585055006587 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055006588 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585055006589 substrate binding site [chemical binding]; other site 585055006590 dimer interface [polypeptide binding]; other site 585055006591 ATP binding site [chemical binding]; other site 585055006592 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 585055006593 fragment of membrane protein (part 1);Evidence 7 : Gene remnant 585055006594 fragment of membrane protein (part 2);Evidence 7 : Gene remnant 585055006595 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585055006596 active site 585055006597 substrate binding pocket [chemical binding]; other site 585055006598 homodimer interaction site [polypeptide binding]; other site 585055006599 fragment of gamma-glutamyltranspeptidase (partial);Evidence 7 : Gene remnant; Product type e : enzyme 585055006600 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 585055006601 fragment of transposase (fragment) (partial);Evidence 7 : Gene remnant 585055006602 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 585055006603 Transposase; Region: DDE_Tnp_ISL3; pfam01610 585055006604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585055006605 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585055006606 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585055006607 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585055006608 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 585055006609 similar to hypothetical protein; Evidence 6 : Doubtful CDS 585055006610 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 585055006611 homodimer interface [polypeptide binding]; other site 585055006612 putative GKAP docking site [polypeptide binding]; other site 585055006613 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585055006614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055006615 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585055006616 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585055006617 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585055006618 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585055006619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055006620 fragment of GTP-binding domain (part 1);Evidence 7 : Gene remnant 585055006621 fragment of GTP-binding domain (part 2);Evidence 7 : Gene remnant 585055006622 hypothetical protein; Provisional; Region: PRK09866 585055006623 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585055006624 G1 box; other site 585055006625 GTP/Mg2+ binding site [chemical binding]; other site 585055006626 G2 box; other site 585055006627 Switch I region; other site 585055006628 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585055006629 G3 box; other site 585055006630 Switch II region; other site 585055006631 GTP/Mg2+ binding site [chemical binding]; other site 585055006632 G4 box; other site 585055006633 G5 box; other site 585055006634 YjcZ-like protein; Region: YjcZ; pfam13990 585055006635 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 585055006636 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585055006637 nucleophile elbow; other site 585055006638 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585055006639 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585055006640 Antirestriction protein; Region: Antirestrict; pfam03230 585055006641 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585055006642 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585055006643 MPN+ (JAMM) motif; other site 585055006644 Zinc-binding site [ion binding]; other site 585055006645 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585055006646 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585055006647 fragment of toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055006648 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585055006649 Switch II region; other site 585055006650 G4 box; other site 585055006651 G5 box; other site 585055006652 hypothetical protein; Provisional; Region: PRK05423 585055006653 Predicted membrane protein [Function unknown]; Region: COG1289 585055006654 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585055006655 DNA gyrase inhibitor; Provisional; Region: PRK10016 585055006656 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 585055006657 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585055006658 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 585055006659 exonuclease I; Provisional; Region: sbcB; PRK11779 585055006660 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 585055006661 active site 585055006662 catalytic site [active] 585055006663 substrate binding site [chemical binding]; other site 585055006664 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 585055006665 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 585055006666 CPxP motif; other site 585055006667 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 585055006668 Sulphur transport; Region: Sulf_transp; pfam04143 585055006669 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585055006670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055006671 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585055006672 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055006673 dimerization interface [polypeptide binding]; other site 585055006674 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585055006675 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 585055006676 putative NAD(P) binding site [chemical binding]; other site 585055006677 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 585055006678 antitoxin YefM; Provisional; Region: PRK11409 585055006679 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 585055006680 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 585055006681 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 585055006682 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 585055006683 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 585055006684 NAD binding site [chemical binding]; other site 585055006685 dimerization interface [polypeptide binding]; other site 585055006686 product binding site; other site 585055006687 substrate binding site [chemical binding]; other site 585055006688 zinc binding site [ion binding]; other site 585055006689 catalytic residues [active] 585055006690 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 585055006691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055006692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055006693 homodimer interface [polypeptide binding]; other site 585055006694 catalytic residue [active] 585055006695 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 585055006696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055006697 active site 585055006698 motif I; other site 585055006699 motif II; other site 585055006700 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 585055006701 putative active site pocket [active] 585055006702 4-fold oligomerization interface [polypeptide binding]; other site 585055006703 metal binding residues [ion binding]; metal-binding site 585055006704 3-fold/trimer interface [polypeptide binding]; other site 585055006705 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 585055006706 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 585055006707 putative active site [active] 585055006708 oxyanion strand; other site 585055006709 catalytic triad [active] 585055006710 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 585055006711 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 585055006712 catalytic residues [active] 585055006713 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 585055006714 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 585055006715 substrate binding site [chemical binding]; other site 585055006716 glutamase interaction surface [polypeptide binding]; other site 585055006717 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 585055006718 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 585055006719 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 585055006720 metal binding site [ion binding]; metal-binding site 585055006721 chain length determinant protein WzzB; Provisional; Region: PRK15471 585055006722 Chain length determinant protein; Region: Wzz; pfam02706 585055006723 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 585055006724 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585055006725 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585055006726 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585055006727 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585055006728 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 585055006729 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 585055006730 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 585055006731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585055006732 active site 585055006733 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585055006734 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585055006735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585055006736 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 585055006737 putative ADP-binding pocket [chemical binding]; other site 585055006738 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 585055006739 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 585055006740 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 585055006741 active site 585055006742 homodimer interface [polypeptide binding]; other site 585055006743 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 585055006744 ligand binding site; other site 585055006745 tetramer interface; other site 585055006746 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 585055006747 active site 585055006748 catalytic triad [active] 585055006749 oxyanion hole [active] 585055006750 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 585055006751 NeuB family; Region: NeuB; pfam03102 585055006752 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 585055006753 NeuB binding interface [polypeptide binding]; other site 585055006754 putative substrate binding site [chemical binding]; other site 585055006755 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 585055006756 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 585055006757 putative trimer interface [polypeptide binding]; other site 585055006758 putative CoA binding site [chemical binding]; other site 585055006759 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585055006760 active site 585055006761 tetramer interface; other site 585055006762 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 585055006763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585055006764 putative NAD(P) binding site [chemical binding]; other site 585055006765 active site 585055006766 putative substrate binding site [chemical binding]; other site 585055006767 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 585055006768 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 585055006769 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 585055006770 putative ADP-binding pocket [chemical binding]; other site 585055006771 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 585055006772 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 585055006773 colanic acid exporter; Provisional; Region: PRK10459 585055006774 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 585055006775 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 585055006776 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 585055006777 phosphomannomutase CpsG; Provisional; Region: PRK15414 585055006778 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 585055006779 active site 585055006780 substrate binding site [chemical binding]; other site 585055006781 metal binding site [ion binding]; metal-binding site 585055006782 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 585055006783 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 585055006784 Substrate binding site; other site 585055006785 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 585055006786 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 585055006787 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 585055006788 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 585055006789 active site 585055006790 GDP-Mannose binding site [chemical binding]; other site 585055006791 dimer interface [polypeptide binding]; other site 585055006792 modified nudix motif 585055006793 metal binding site [ion binding]; metal-binding site 585055006794 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 585055006795 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 585055006796 NADP binding site [chemical binding]; other site 585055006797 active site 585055006798 putative substrate binding site [chemical binding]; other site 585055006799 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 585055006800 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 585055006801 NADP-binding site; other site 585055006802 homotetramer interface [polypeptide binding]; other site 585055006803 substrate binding site [chemical binding]; other site 585055006804 homodimer interface [polypeptide binding]; other site 585055006805 active site 585055006806 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 585055006807 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 585055006808 putative trimer interface [polypeptide binding]; other site 585055006809 putative active site [active] 585055006810 putative substrate binding site [chemical binding]; other site 585055006811 putative CoA binding site [chemical binding]; other site 585055006812 putative glycosyl transferase; Provisional; Region: PRK10063 585055006813 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 585055006814 metal-binding site 585055006815 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 585055006816 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585055006817 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 585055006818 putative acyl transferase; Provisional; Region: PRK10191 585055006819 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585055006820 trimer interface [polypeptide binding]; other site 585055006821 active site 585055006822 substrate binding site [chemical binding]; other site 585055006823 CoA binding site [chemical binding]; other site 585055006824 putative glycosyl transferase; Provisional; Region: PRK10018 585055006825 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 585055006826 active site 585055006827 tyrosine kinase; Provisional; Region: PRK11519 585055006828 Chain length determinant protein; Region: Wzz; pfam02706 585055006829 Chain length determinant protein; Region: Wzz; cl15801 585055006830 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585055006831 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585055006832 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585055006833 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585055006834 active site 585055006835 polysaccharide export protein Wza; Provisional; Region: PRK15078 585055006836 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585055006837 SLBB domain; Region: SLBB; pfam10531 585055006838 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585055006839 FOG: CBS domain [General function prediction only]; Region: COG0517 585055006840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585055006841 Transporter associated domain; Region: CorC_HlyC; smart01091 585055006842 putative assembly protein; Provisional; Region: PRK10833 585055006843 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585055006844 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585055006845 trimer interface [polypeptide binding]; other site 585055006846 active site 585055006847 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 585055006848 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 585055006849 ATP-binding site [chemical binding]; other site 585055006850 Sugar specificity; other site 585055006851 Pyrimidine base specificity; other site 585055006852 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 585055006853 putative diguanylate cyclase; Provisional; Region: PRK09776 585055006854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055006855 putative active site [active] 585055006856 heme pocket [chemical binding]; other site 585055006857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055006858 putative active site [active] 585055006859 heme pocket [chemical binding]; other site 585055006860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055006861 putative active site [active] 585055006862 heme pocket [chemical binding]; other site 585055006863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055006864 metal binding site [ion binding]; metal-binding site 585055006865 active site 585055006866 I-site; other site 585055006867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 585055006868 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 585055006869 AlkA N-terminal domain; Region: AlkA_N; smart01009 585055006870 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585055006871 minor groove reading motif; other site 585055006872 helix-hairpin-helix signature motif; other site 585055006873 substrate binding pocket [chemical binding]; other site 585055006874 active site 585055006875 putative chaperone; Provisional; Region: PRK11678 585055006876 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 585055006877 nucleotide binding site [chemical binding]; other site 585055006878 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585055006879 SBD interface [polypeptide binding]; other site 585055006880 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 585055006881 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585055006882 substrate binding site [chemical binding]; other site 585055006883 activation loop (A-loop); other site 585055006884 Y-family of DNA polymerases; Region: PolY; cl12025 585055006885 Protein phosphatase 2C; Region: PP2C_2; pfam13672 585055006886 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 585055006887 metal ion-dependent adhesion site (MIDAS); other site 585055006888 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 585055006889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055006890 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055006891 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 585055006892 Protein export membrane protein; Region: SecD_SecF; cl14618 585055006893 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 585055006894 putative transporter; Provisional; Region: PRK10504 585055006895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055006896 putative substrate translocation pore; other site 585055006897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055006898 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 585055006899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055006900 dimerization interface [polypeptide binding]; other site 585055006901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055006902 dimer interface [polypeptide binding]; other site 585055006903 phosphorylation site [posttranslational modification] 585055006904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055006905 ATP binding site [chemical binding]; other site 585055006906 Mg2+ binding site [ion binding]; other site 585055006907 G-X-G motif; other site 585055006908 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 585055006909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055006910 active site 585055006911 phosphorylation site [posttranslational modification] 585055006912 intermolecular recognition site; other site 585055006913 dimerization interface [polypeptide binding]; other site 585055006914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055006915 DNA binding site [nucleotide binding] 585055006916 Uncharacterized conserved protein [Function unknown]; Region: COG3422 585055006917 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 585055006918 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 585055006919 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585055006920 putative protease; Provisional; Region: PRK15452 585055006921 Peptidase family U32; Region: Peptidase_U32; pfam01136 585055006922 lipid kinase; Reviewed; Region: PRK13054 585055006923 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 585055006924 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585055006925 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585055006926 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055006927 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 585055006928 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 585055006929 putative NAD(P) binding site [chemical binding]; other site 585055006930 catalytic Zn binding site [ion binding]; other site 585055006931 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585055006932 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 585055006933 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585055006934 active site 585055006935 P-loop; other site 585055006936 phosphorylation site [posttranslational modification] 585055006937 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055006938 active site 585055006939 phosphorylation site [posttranslational modification] 585055006940 fragment of D-tagatose 1,6-bisphosphate aldolase 2, subunit (part 2);Evidence 7 : Gene remnant; Product type e : enzyme 585055006941 fragment of D-tagatose 1,6-bisphosphate aldolase 2, subunit (part 1);Evidence 7 : Gene remnant; Product type e : enzyme 585055006942 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585055006943 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585055006944 intersubunit interface [polypeptide binding]; other site 585055006945 active site 585055006946 zinc binding site [ion binding]; other site 585055006947 Na+ binding site [ion binding]; other site 585055006948 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 585055006949 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585055006950 putative active site; other site 585055006951 catalytic residue [active] 585055006952 nucleoside transporter; Region: 2A0110; TIGR00889 585055006953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055006954 putative substrate translocation pore; other site 585055006955 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 585055006956 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055006957 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 585055006958 substrate binding site [chemical binding]; other site 585055006959 ATP binding site [chemical binding]; other site 585055006960 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585055006961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055006962 DNA-binding site [nucleotide binding]; DNA binding site 585055006963 UTRA domain; Region: UTRA; pfam07702 585055006964 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 585055006965 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 585055006966 active site 585055006967 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 585055006968 dimer interface [polypeptide binding]; other site 585055006969 substrate binding site [chemical binding]; other site 585055006970 ATP binding site [chemical binding]; other site 585055006971 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 585055006972 substrate binding site [chemical binding]; other site 585055006973 multimerization interface [polypeptide binding]; other site 585055006974 ATP binding site [chemical binding]; other site 585055006975 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585055006976 putative metal binding site [ion binding]; other site 585055006977 putative homodimer interface [polypeptide binding]; other site 585055006978 putative homotetramer interface [polypeptide binding]; other site 585055006979 putative homodimer-homodimer interface [polypeptide binding]; other site 585055006980 putative allosteric switch controlling residues; other site 585055006981 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 585055006982 Predicted integral membrane protein [Function unknown]; Region: COG5455 585055006983 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 585055006984 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 585055006985 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 585055006986 PapC N-terminal domain; Region: PapC_N; pfam13954 585055006987 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055006988 PapC C-terminal domain; Region: PapC_C; pfam13953 585055006989 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 585055006990 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055006991 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055006992 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585055006993 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 585055006994 antiporter inner membrane protein; Provisional; Region: PRK11670 585055006995 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 585055006996 Walker A motif; other site 585055006997 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 585055006998 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 585055006999 active site 585055007000 HIGH motif; other site 585055007001 KMSKS motif; other site 585055007002 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 585055007003 tRNA binding surface [nucleotide binding]; other site 585055007004 anticodon binding site; other site 585055007005 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 585055007006 dimer interface [polypeptide binding]; other site 585055007007 putative tRNA-binding site [nucleotide binding]; other site 585055007008 fragment of Molybdate metabolism regulator (molR) (partial);Evidence 7 : Gene remnant; Product type pr : regulator 585055007009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055007010 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055007011 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055007012 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055007013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 585055007014 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585055007015 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585055007016 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 585055007017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055007018 active site 585055007019 phosphorylation site [posttranslational modification] 585055007020 intermolecular recognition site; other site 585055007021 dimerization interface [polypeptide binding]; other site 585055007022 LytTr DNA-binding domain; Region: LytTR; pfam04397 585055007023 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585055007024 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585055007025 GAF domain; Region: GAF; pfam01590 585055007026 Histidine kinase; Region: His_kinase; pfam06580 585055007027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055007028 ATP binding site [chemical binding]; other site 585055007029 Mg2+ binding site [ion binding]; other site 585055007030 G-X-G motif; other site 585055007031 transcriptional regulator MirA; Provisional; Region: PRK15043 585055007032 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 585055007033 DNA binding residues [nucleotide binding] 585055007034 hypothetical protein; Provisional; Region: PRK13681 585055007035 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585055007036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055007037 dimer interface [polypeptide binding]; other site 585055007038 conserved gate region; other site 585055007039 putative PBP binding loops; other site 585055007040 ABC-ATPase subunit interface; other site 585055007041 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 585055007042 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 585055007043 Walker A/P-loop; other site 585055007044 ATP binding site [chemical binding]; other site 585055007045 Q-loop/lid; other site 585055007046 ABC transporter signature motif; other site 585055007047 Walker B; other site 585055007048 D-loop; other site 585055007049 H-loop/switch region; other site 585055007050 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 585055007051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055007052 dimer interface [polypeptide binding]; other site 585055007053 conserved gate region; other site 585055007054 ABC-ATPase subunit interface; other site 585055007055 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 585055007056 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 585055007057 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 585055007058 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 585055007059 D-lactate dehydrogenase; Provisional; Region: PRK11183 585055007060 FAD binding domain; Region: FAD_binding_4; pfam01565 585055007061 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 585055007062 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 585055007063 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 585055007064 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 585055007065 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585055007066 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585055007067 oxidoreductase; Provisional; Region: PRK12743 585055007068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585055007069 NAD(P) binding site [chemical binding]; other site 585055007070 active site 585055007071 Outer membrane efflux protein; Region: OEP; pfam02321 585055007072 Outer membrane efflux protein; Region: OEP; pfam02321 585055007073 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 585055007074 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585055007075 FMN binding site [chemical binding]; other site 585055007076 active site 585055007077 catalytic residues [active] 585055007078 substrate binding site [chemical binding]; other site 585055007079 hypothetical protein; Provisional; Region: PRK01821 585055007080 hypothetical protein; Provisional; Region: PRK10711 585055007081 cytidine deaminase; Provisional; Region: PRK09027 585055007082 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585055007083 active site 585055007084 catalytic motif [active] 585055007085 Zn binding site [ion binding]; other site 585055007086 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585055007087 active site 585055007088 catalytic motif [active] 585055007089 Zn binding site [ion binding]; other site 585055007090 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585055007091 putative active site [active] 585055007092 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 585055007093 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 585055007094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585055007095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055007096 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 585055007097 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 585055007098 homodimer interface [polypeptide binding]; other site 585055007099 active site 585055007100 FMN binding site [chemical binding]; other site 585055007101 substrate binding site [chemical binding]; other site 585055007102 4Fe-4S binding domain; Region: Fer4; pfam00037 585055007103 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055007104 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055007105 TM-ABC transporter signature motif; other site 585055007106 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055007107 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 585055007108 Walker A/P-loop; other site 585055007109 ATP binding site [chemical binding]; other site 585055007110 Q-loop/lid; other site 585055007111 ABC transporter signature motif; other site 585055007112 Walker B; other site 585055007113 D-loop; other site 585055007114 H-loop/switch region; other site 585055007115 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055007116 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 585055007117 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 585055007118 ligand binding site [chemical binding]; other site 585055007119 calcium binding site [ion binding]; other site 585055007120 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 585055007121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055007122 DNA binding site [nucleotide binding] 585055007123 domain linker motif; other site 585055007124 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585055007125 dimerization interface (closed form) [polypeptide binding]; other site 585055007126 ligand binding site [chemical binding]; other site 585055007127 Predicted membrane protein [Function unknown]; Region: COG2311 585055007128 hypothetical protein; Provisional; Region: PRK10835 585055007129 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 585055007130 homodecamer interface [polypeptide binding]; other site 585055007131 GTP cyclohydrolase I; Provisional; Region: PLN03044 585055007132 active site 585055007133 putative catalytic site residues [active] 585055007134 zinc binding site [ion binding]; other site 585055007135 GTP-CH-I/GFRP interaction surface; other site 585055007136 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585055007137 S-formylglutathione hydrolase; Region: PLN02442 585055007138 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 585055007139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055007140 N-terminal plug; other site 585055007141 ligand-binding site [chemical binding]; other site 585055007142 lysine transporter; Provisional; Region: PRK10836 585055007143 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 585055007144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055007145 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 585055007146 putative dimerization interface [polypeptide binding]; other site 585055007147 conserved hypothetical integral membrane protein; Region: TIGR00698 585055007148 endonuclease IV; Provisional; Region: PRK01060 585055007149 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585055007150 AP (apurinic/apyrimidinic) site pocket; other site 585055007151 DNA interaction; other site 585055007152 Metal-binding active site; metal-binding site 585055007153 putative kinase; Provisional; Region: PRK09954 585055007154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055007155 putative DNA binding site [nucleotide binding]; other site 585055007156 putative Zn2+ binding site [ion binding]; other site 585055007157 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585055007158 substrate binding site [chemical binding]; other site 585055007159 ATP binding site [chemical binding]; other site 585055007160 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585055007161 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585055007162 Nucleoside recognition; Region: Gate; pfam07670 585055007163 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585055007164 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585055007165 active site 585055007166 tetramer interface [polypeptide binding]; other site 585055007167 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 585055007168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585055007169 ligand binding site [chemical binding]; other site 585055007170 flexible hinge region; other site 585055007171 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585055007172 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585055007173 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585055007174 Nucleoside recognition; Region: Gate; pfam07670 585055007175 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585055007176 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 585055007177 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585055007178 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055007179 substrate binding site [chemical binding]; other site 585055007180 ATP binding site [chemical binding]; other site 585055007181 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 585055007182 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 585055007183 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585055007184 active site 585055007185 P-loop; other site 585055007186 phosphorylation site [posttranslational modification] 585055007187 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 585055007188 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 585055007189 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585055007190 putative substrate binding site [chemical binding]; other site 585055007191 putative ATP binding site [chemical binding]; other site 585055007192 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 585055007193 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055007194 active site 585055007195 phosphorylation site [posttranslational modification] 585055007196 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585055007197 dimerization domain swap beta strand [polypeptide binding]; other site 585055007198 regulatory protein interface [polypeptide binding]; other site 585055007199 active site 585055007200 regulatory phosphorylation site [posttranslational modification]; other site 585055007201 sugar efflux transporter B; Provisional; Region: PRK15011 585055007202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007203 putative substrate translocation pore; other site 585055007204 Flagellin N-methylase; Region: FliB; pfam03692 585055007205 elongation factor P; Provisional; Region: PRK04542 585055007206 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585055007207 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585055007208 RNA binding site [nucleotide binding]; other site 585055007209 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585055007210 RNA binding site [nucleotide binding]; other site 585055007211 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585055007212 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585055007213 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585055007214 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 585055007215 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 585055007216 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 585055007217 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585055007218 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585055007219 active site 585055007220 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 585055007221 NlpC/P60 family; Region: NLPC_P60; pfam00877 585055007222 phage resistance protein; Provisional; Region: PRK10551 585055007223 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585055007224 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055007225 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585055007226 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 585055007227 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 585055007228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055007229 dimer interface [polypeptide binding]; other site 585055007230 conserved gate region; other site 585055007231 putative PBP binding loops; other site 585055007232 ABC-ATPase subunit interface; other site 585055007233 microcin C ABC transporter permease; Provisional; Region: PRK15021 585055007234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055007235 dimer interface [polypeptide binding]; other site 585055007236 conserved gate region; other site 585055007237 ABC-ATPase subunit interface; other site 585055007238 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 585055007239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055007240 Walker A/P-loop; other site 585055007241 ATP binding site [chemical binding]; other site 585055007242 Q-loop/lid; other site 585055007243 ABC transporter signature motif; other site 585055007244 Walker B; other site 585055007245 D-loop; other site 585055007246 H-loop/switch region; other site 585055007247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585055007248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055007249 Walker A/P-loop; other site 585055007250 ATP binding site [chemical binding]; other site 585055007251 Q-loop/lid; other site 585055007252 ABC transporter signature motif; other site 585055007253 Walker B; other site 585055007254 D-loop; other site 585055007255 H-loop/switch region; other site 585055007256 hypothetical protein; Provisional; Region: PRK11835 585055007257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007258 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 585055007259 putative substrate translocation pore; other site 585055007260 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 585055007261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055007262 RNA binding surface [nucleotide binding]; other site 585055007263 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 585055007264 active site 585055007265 uracil binding [chemical binding]; other site 585055007266 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585055007267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055007268 ATP binding site [chemical binding]; other site 585055007269 putative Mg++ binding site [ion binding]; other site 585055007270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055007271 nucleotide binding region [chemical binding]; other site 585055007272 ATP-binding site [chemical binding]; other site 585055007273 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 585055007274 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 585055007275 5S rRNA interface [nucleotide binding]; other site 585055007276 CTC domain interface [polypeptide binding]; other site 585055007277 L16 interface [polypeptide binding]; other site 585055007278 Nucleoid-associated protein [General function prediction only]; Region: COG3081 585055007279 nucleoid-associated protein NdpA; Validated; Region: PRK00378 585055007280 hypothetical protein; Provisional; Region: PRK13689 585055007281 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 585055007282 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 585055007283 Sulfatase; Region: Sulfatase; pfam00884 585055007284 fragment of autotransporter outer membrane protein; type V secretion (part 2);Evidence 7 : Gene remnant; Product type pt : transporter 585055007285 fragment of autotransporter outer membrane protein; type V secretion (part 1);Evidence 7 : Gene remnant; Product type pt : transporter 585055007286 transcriptional regulator NarP; Provisional; Region: PRK10403 585055007287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055007288 active site 585055007289 phosphorylation site [posttranslational modification] 585055007290 intermolecular recognition site; other site 585055007291 dimerization interface [polypeptide binding]; other site 585055007292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055007293 DNA binding residues [nucleotide binding] 585055007294 dimerization interface [polypeptide binding]; other site 585055007295 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 585055007296 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585055007297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055007298 binding surface 585055007299 TPR motif; other site 585055007300 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 585055007301 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 585055007302 catalytic residues [active] 585055007303 central insert; other site 585055007304 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 585055007305 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 585055007306 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 585055007307 heme exporter protein CcmC; Region: ccmC; TIGR01191 585055007308 heme exporter protein CcmB; Region: ccmB; TIGR01190 585055007309 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 585055007310 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 585055007311 Walker A/P-loop; other site 585055007312 ATP binding site [chemical binding]; other site 585055007313 Q-loop/lid; other site 585055007314 ABC transporter signature motif; other site 585055007315 Walker B; other site 585055007316 D-loop; other site 585055007317 H-loop/switch region; other site 585055007318 cytochrome c-type protein NapC; Provisional; Region: PRK10617 585055007319 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 585055007320 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 585055007321 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 585055007322 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585055007323 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585055007324 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 585055007325 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 585055007326 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 585055007327 [4Fe-4S] binding site [ion binding]; other site 585055007328 molybdopterin cofactor binding site; other site 585055007329 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 585055007330 molybdopterin cofactor binding site; other site 585055007331 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 585055007332 ferredoxin-type protein; Provisional; Region: PRK10194 585055007333 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 585055007334 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 585055007335 secondary substrate binding site; other site 585055007336 primary substrate binding site; other site 585055007337 inhibition loop; other site 585055007338 dimerization interface [polypeptide binding]; other site 585055007339 malate:quinone oxidoreductase; Validated; Region: PRK05257 585055007340 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 585055007341 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 585055007342 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 585055007343 Walker A/P-loop; other site 585055007344 ATP binding site [chemical binding]; other site 585055007345 Q-loop/lid; other site 585055007346 ABC transporter signature motif; other site 585055007347 Walker B; other site 585055007348 D-loop; other site 585055007349 H-loop/switch region; other site 585055007350 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 585055007351 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 585055007352 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 585055007353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055007354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055007355 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585055007356 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585055007357 DNA binding site [nucleotide binding] 585055007358 active site 585055007359 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 585055007360 ApbE family; Region: ApbE; pfam02424 585055007361 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585055007362 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585055007363 trimer interface [polypeptide binding]; other site 585055007364 eyelet of channel; other site 585055007365 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 585055007366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055007367 ATP binding site [chemical binding]; other site 585055007368 G-X-G motif; other site 585055007369 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585055007370 putative binding surface; other site 585055007371 active site 585055007372 transcriptional regulator RcsB; Provisional; Region: PRK10840 585055007373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055007374 active site 585055007375 phosphorylation site [posttranslational modification] 585055007376 intermolecular recognition site; other site 585055007377 dimerization interface [polypeptide binding]; other site 585055007378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055007379 DNA binding residues [nucleotide binding] 585055007380 dimerization interface [polypeptide binding]; other site 585055007381 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 585055007382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055007383 dimer interface [polypeptide binding]; other site 585055007384 phosphorylation site [posttranslational modification] 585055007385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055007386 ATP binding site [chemical binding]; other site 585055007387 Mg2+ binding site [ion binding]; other site 585055007388 G-X-G motif; other site 585055007389 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 585055007390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055007391 active site 585055007392 phosphorylation site [posttranslational modification] 585055007393 intermolecular recognition site; other site 585055007394 dimerization interface [polypeptide binding]; other site 585055007395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 585055007396 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 585055007397 Predicted secreted protein [Function unknown]; Region: COG5445 585055007398 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585055007399 Predicted secreted protein [Function unknown]; Region: COG5445 585055007400 Stage II sporulation protein; Region: SpoIID; pfam08486 585055007401 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585055007402 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585055007403 MG2 domain; Region: A2M_N; pfam01835 585055007404 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 585055007405 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585055007406 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 585055007407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 585055007408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 585055007409 DNA gyrase subunit A; Validated; Region: PRK05560 585055007410 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585055007411 CAP-like domain; other site 585055007412 active site 585055007413 primary dimer interface [polypeptide binding]; other site 585055007414 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585055007415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585055007416 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585055007417 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585055007418 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585055007419 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585055007420 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 585055007421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055007422 S-adenosylmethionine binding site [chemical binding]; other site 585055007423 adhesin; Provisional; Region: PRK09752 585055007424 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585055007425 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055007426 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 585055007427 ATP cone domain; Region: ATP-cone; pfam03477 585055007428 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585055007429 active site 585055007430 dimer interface [polypeptide binding]; other site 585055007431 catalytic residues [active] 585055007432 effector binding site; other site 585055007433 R2 peptide binding site; other site 585055007434 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585055007435 dimer interface [polypeptide binding]; other site 585055007436 putative radical transfer pathway; other site 585055007437 diiron center [ion binding]; other site 585055007438 tyrosyl radical; other site 585055007439 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585055007440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055007441 catalytic loop [active] 585055007442 iron binding site [ion binding]; other site 585055007443 hypothetical protein; Provisional; Region: PRK09902 585055007444 fragment of antibiotic efflux protein ( antibiotic resistance protein) (partial);Evidence 7 : Gene remnant; Product type pt : transporter 585055007445 hypothetical protein; Provisional; Region: PRK09729 585055007446 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 585055007447 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 585055007448 active site 585055007449 catalytic site [active] 585055007450 metal binding site [ion binding]; metal-binding site 585055007451 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 585055007452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007453 putative substrate translocation pore; other site 585055007454 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 585055007455 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585055007456 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585055007457 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 585055007458 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 585055007459 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 585055007460 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055007461 Cysteine-rich domain; Region: CCG; pfam02754 585055007462 Cysteine-rich domain; Region: CCG; pfam02754 585055007463 hypothetical protein; Provisional; Region: PRK09956 585055007464 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585055007465 fragment of 2,4-dihydroxyhept-2-ene-1, 7-dioic acid-like aldolase (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055007466 hypothetical protein; Provisional; Region: PRK03673 585055007467 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 585055007468 putative MPT binding site; other site 585055007469 Competence-damaged protein; Region: CinA; cl00666 585055007470 YfaZ precursor; Region: YfaZ; pfam07437 585055007471 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 585055007472 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 585055007473 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 585055007474 catalytic core [active] 585055007475 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585055007476 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585055007477 inhibitor-cofactor binding pocket; inhibition site 585055007478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055007479 catalytic residue [active] 585055007480 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 585055007481 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 585055007482 Ligand binding site; other site 585055007483 Putative Catalytic site; other site 585055007484 DXD motif; other site 585055007485 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 585055007486 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 585055007487 substrate binding site [chemical binding]; other site 585055007488 cosubstrate binding site; other site 585055007489 catalytic site [active] 585055007490 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 585055007491 active site 585055007492 hexamer interface [polypeptide binding]; other site 585055007493 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 585055007494 NAD binding site [chemical binding]; other site 585055007495 substrate binding site [chemical binding]; other site 585055007496 active site 585055007497 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 585055007498 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 585055007499 putative active site [active] 585055007500 putative catalytic site [active] 585055007501 putative Zn binding site [ion binding]; other site 585055007502 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 585055007503 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 585055007504 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 585055007505 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 585055007506 signal transduction protein PmrD; Provisional; Region: PRK15450 585055007507 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 585055007508 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 585055007509 acyl-activating enzyme (AAE) consensus motif; other site 585055007510 putative AMP binding site [chemical binding]; other site 585055007511 putative active site [active] 585055007512 putative CoA binding site [chemical binding]; other site 585055007513 O-succinylbenzoate synthase; Provisional; Region: PRK05105 585055007514 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 585055007515 active site 585055007516 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585055007517 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 585055007518 substrate binding site [chemical binding]; other site 585055007519 oxyanion hole (OAH) forming residues; other site 585055007520 trimer interface [polypeptide binding]; other site 585055007521 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 585055007522 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 585055007523 catalytic site [active] 585055007524 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 585055007525 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 585055007526 dimer interface [polypeptide binding]; other site 585055007527 tetramer interface [polypeptide binding]; other site 585055007528 PYR/PP interface [polypeptide binding]; other site 585055007529 TPP binding site [chemical binding]; other site 585055007530 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 585055007531 TPP-binding site; other site 585055007532 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 585055007533 isochorismate synthases; Region: isochor_syn; TIGR00543 585055007534 hypothetical protein; Provisional; Region: PRK10404 585055007535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055007536 Coenzyme A binding pocket [chemical binding]; other site 585055007537 ribonuclease BN; Region: true_RNase_BN; TIGR02649 585055007538 deubiquitinase; Provisional; Region: PRK11836 585055007539 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 585055007540 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 585055007541 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 585055007542 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585055007543 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 585055007544 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585055007545 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 585055007546 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 585055007547 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585055007548 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 585055007549 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 585055007550 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 585055007551 4Fe-4S binding domain; Region: Fer4; pfam00037 585055007552 4Fe-4S binding domain; Region: Fer4; pfam00037 585055007553 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 585055007554 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 585055007555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055007556 catalytic loop [active] 585055007557 iron binding site [ion binding]; other site 585055007558 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 585055007559 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 585055007560 [4Fe-4S] binding site [ion binding]; other site 585055007561 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 585055007562 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 585055007563 SLBB domain; Region: SLBB; pfam10531 585055007564 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 585055007565 NADH dehydrogenase subunit E; Validated; Region: PRK07539 585055007566 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 585055007567 putative dimer interface [polypeptide binding]; other site 585055007568 [2Fe-2S] cluster binding site [ion binding]; other site 585055007569 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 585055007570 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 585055007571 NADH dehydrogenase subunit D; Validated; Region: PRK06075 585055007572 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 585055007573 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 585055007574 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 585055007575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055007576 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 585055007577 putative dimerization interface [polypeptide binding]; other site 585055007578 aminotransferase AlaT; Validated; Region: PRK09265 585055007579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055007580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055007581 homodimer interface [polypeptide binding]; other site 585055007582 catalytic residue [active] 585055007583 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585055007584 Zn2+ binding site [ion binding]; other site 585055007585 Mg2+ binding site [ion binding]; other site 585055007586 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585055007587 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585055007588 TrkA-C domain; Region: TrkA_C; pfam02080 585055007589 TrkA-C domain; Region: TrkA_C; pfam02080 585055007590 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585055007591 putative phosphatase; Provisional; Region: PRK11587 585055007592 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585055007593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055007594 motif II; other site 585055007595 hypothetical protein; Validated; Region: PRK05445 585055007596 hypothetical protein; Provisional; Region: PRK01816 585055007597 propionate/acetate kinase; Provisional; Region: PRK12379 585055007598 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 585055007599 phosphate acetyltransferase; Reviewed; Region: PRK05632 585055007600 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585055007601 DRTGG domain; Region: DRTGG; pfam07085 585055007602 phosphate acetyltransferase; Region: pta; TIGR00651 585055007603 hypothetical protein; Provisional; Region: PRK11588 585055007604 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585055007605 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 585055007606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 585055007607 nudix motif; other site 585055007608 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 585055007609 active site 585055007610 metal binding site [ion binding]; metal-binding site 585055007611 homotetramer interface [polypeptide binding]; other site 585055007612 glutathione S-transferase; Provisional; Region: PRK15113 585055007613 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 585055007614 C-terminal domain interface [polypeptide binding]; other site 585055007615 GSH binding site (G-site) [chemical binding]; other site 585055007616 dimer interface [polypeptide binding]; other site 585055007617 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 585055007618 N-terminal domain interface [polypeptide binding]; other site 585055007619 putative dimer interface [polypeptide binding]; other site 585055007620 putative substrate binding pocket (H-site) [chemical binding]; other site 585055007621 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 585055007622 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585055007623 C-terminal domain interface [polypeptide binding]; other site 585055007624 GSH binding site (G-site) [chemical binding]; other site 585055007625 dimer interface [polypeptide binding]; other site 585055007626 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 585055007627 N-terminal domain interface [polypeptide binding]; other site 585055007628 putative dimer interface [polypeptide binding]; other site 585055007629 active site 585055007630 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585055007631 homooctamer interface [polypeptide binding]; other site 585055007632 active site 585055007633 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 585055007634 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 585055007635 putative NAD(P) binding site [chemical binding]; other site 585055007636 putative active site [active] 585055007637 putative transposase; Provisional; Region: PRK09857 585055007638 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585055007639 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 585055007640 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585055007641 Walker A/P-loop; other site 585055007642 ATP binding site [chemical binding]; other site 585055007643 Q-loop/lid; other site 585055007644 ABC transporter signature motif; other site 585055007645 Walker B; other site 585055007646 D-loop; other site 585055007647 H-loop/switch region; other site 585055007648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055007649 dimer interface [polypeptide binding]; other site 585055007650 conserved gate region; other site 585055007651 putative PBP binding loops; other site 585055007652 ABC-ATPase subunit interface; other site 585055007653 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585055007654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055007655 dimer interface [polypeptide binding]; other site 585055007656 conserved gate region; other site 585055007657 putative PBP binding loops; other site 585055007658 ABC-ATPase subunit interface; other site 585055007659 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 585055007660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055007661 substrate binding pocket [chemical binding]; other site 585055007662 membrane-bound complex binding site; other site 585055007663 hinge residues; other site 585055007664 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 585055007665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055007666 substrate binding pocket [chemical binding]; other site 585055007667 membrane-bound complex binding site; other site 585055007668 hinge residues; other site 585055007669 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 585055007670 Flavoprotein; Region: Flavoprotein; pfam02441 585055007671 amidophosphoribosyltransferase; Provisional; Region: PRK09246 585055007672 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 585055007673 active site 585055007674 tetramer interface [polypeptide binding]; other site 585055007675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055007676 active site 585055007677 colicin V production protein; Provisional; Region: PRK10845 585055007678 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 585055007679 cell division protein DedD; Provisional; Region: PRK11633 585055007680 Sporulation related domain; Region: SPOR; pfam05036 585055007681 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 585055007682 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585055007683 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585055007684 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 585055007685 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 585055007686 hypothetical protein; Provisional; Region: PRK10847 585055007687 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585055007688 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 585055007689 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 585055007690 dimerization interface 3.5A [polypeptide binding]; other site 585055007691 active site 585055007692 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 585055007693 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585055007694 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 585055007695 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 585055007696 ligand binding site [chemical binding]; other site 585055007697 NAD binding site [chemical binding]; other site 585055007698 catalytic site [active] 585055007699 homodimer interface [polypeptide binding]; other site 585055007700 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 585055007701 putative transporter; Provisional; Region: PRK12382 585055007702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007703 putative substrate translocation pore; other site 585055007704 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 585055007705 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585055007706 dimer interface [polypeptide binding]; other site 585055007707 active site 585055007708 Uncharacterized conserved protein [Function unknown]; Region: COG4121 585055007709 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 585055007710 YfcL protein; Region: YfcL; pfam08891 585055007711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 585055007712 hypothetical protein; Provisional; Region: PRK10621 585055007713 Predicted permeases [General function prediction only]; Region: COG0730 585055007714 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 585055007715 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 585055007716 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 585055007717 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 585055007718 Tetramer interface [polypeptide binding]; other site 585055007719 active site 585055007720 FMN-binding site [chemical binding]; other site 585055007721 HemK family putative methylases; Region: hemK_fam; TIGR00536 585055007722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055007723 S-adenosylmethionine binding site [chemical binding]; other site 585055007724 hypothetical protein; Provisional; Region: PRK04946 585055007725 Smr domain; Region: Smr; pfam01713 585055007726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055007727 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055007728 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055007729 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 585055007730 Fimbrial protein; Region: Fimbrial; cl01416 585055007731 Fimbrial protein; Region: Fimbrial; cl01416 585055007732 Fimbrial protein; Region: Fimbrial; cl01416 585055007733 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055007734 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055007735 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 585055007736 PapC N-terminal domain; Region: PapC_N; pfam13954 585055007737 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055007738 PapC C-terminal domain; Region: PapC_C; pfam13953 585055007739 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585055007740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585055007741 catalytic core [active] 585055007742 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 585055007743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585055007744 substrate binding site [chemical binding]; other site 585055007745 oxyanion hole (OAH) forming residues; other site 585055007746 trimer interface [polypeptide binding]; other site 585055007747 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585055007748 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585055007749 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 585055007750 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585055007751 dimer interface [polypeptide binding]; other site 585055007752 active site 585055007753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 585055007754 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 585055007755 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 585055007756 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 585055007757 integrase; Provisional; Region: PRK09692 585055007758 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585055007759 active site 585055007760 Int/Topo IB signature motif; other site 585055007761 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 585055007762 Head binding; Region: Head_binding; pfam09008 585055007763 Arc-like DNA binding domain; Region: Arc; pfam03869 585055007764 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 585055007765 BRO family, N-terminal domain; Region: Bro-N; smart01040 585055007766 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 585055007767 Arc-like DNA binding domain; Region: Arc; pfam03869 585055007768 Arc-like DNA binding domain; Region: Arc; pfam03869 585055007769 YjzC-like protein; Region: YjzC; pfam14168 585055007770 hypothetical protein; Region: PHA00527 585055007771 DNA transfer protein (fragment);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055007772 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 585055007773 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 585055007774 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 585055007775 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 585055007776 Phage terminase large subunit; Region: Terminase_3; pfam04466 585055007777 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 585055007778 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 585055007779 hypothetical protein; Region: PHA01971 585055007780 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 585055007781 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585055007782 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585055007783 catalytic residues [active] 585055007784 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055007785 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585055007786 Endodeoxyribonuclease RusA; Region: RusA; cl01885 585055007787 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 585055007788 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585055007789 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 585055007790 NinF protein; Region: NinF; pfam05810 585055007791 NinB protein; Region: NinB; pfam05772 585055007792 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585055007793 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 585055007794 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 585055007795 Walker A motif; other site 585055007796 ATP binding site [chemical binding]; other site 585055007797 Walker B motif; other site 585055007798 Bacteriophage CII protein; Region: Phage_CII; pfam05269 585055007799 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585055007800 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585055007801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055007802 non-specific DNA binding site [nucleotide binding]; other site 585055007803 salt bridge; other site 585055007804 sequence-specific DNA binding site [nucleotide binding]; other site 585055007805 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585055007806 Catalytic site [active] 585055007807 fragment of regulatory protein N (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055007808 ERF superfamily; Region: ERF; pfam04404 585055007809 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 585055007810 fragment of Conserved hypothetical protein (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585055007811 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585055007812 Protein of unknown function (DUF550); Region: DUF550; pfam04447 585055007813 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585055007814 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 585055007815 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 585055007816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007817 putative substrate translocation pore; other site 585055007818 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055007819 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 585055007820 putative substrate binding site [chemical binding]; other site 585055007821 putative ATP binding site [chemical binding]; other site 585055007822 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 585055007823 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 585055007824 substrate binding [chemical binding]; other site 585055007825 active site 585055007826 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 585055007827 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055007828 DNA binding site [nucleotide binding] 585055007829 domain linker motif; other site 585055007830 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585055007831 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 585055007832 putative dimerization interface [polypeptide binding]; other site 585055007833 putative ligand binding site [chemical binding]; other site 585055007834 fragment of transporter (partial);Evidence 7 : Gene remnant; Product type pt : transporter 585055007835 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 585055007836 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 585055007837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585055007838 catalytic residue [active] 585055007839 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585055007840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007841 putative substrate translocation pore; other site 585055007842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007843 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 585055007844 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055007845 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055007846 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 585055007847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055007848 active site 585055007849 phosphorylation site [posttranslational modification] 585055007850 intermolecular recognition site; other site 585055007851 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055007852 DNA binding residues [nucleotide binding] 585055007853 dimerization interface [polypeptide binding]; other site 585055007854 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 585055007855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055007856 substrate binding pocket [chemical binding]; other site 585055007857 membrane-bound complex binding site; other site 585055007858 hinge residues; other site 585055007859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055007860 substrate binding pocket [chemical binding]; other site 585055007861 membrane-bound complex binding site; other site 585055007862 hinge residues; other site 585055007863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055007864 dimer interface [polypeptide binding]; other site 585055007865 phosphorylation site [posttranslational modification] 585055007866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055007867 ATP binding site [chemical binding]; other site 585055007868 Mg2+ binding site [ion binding]; other site 585055007869 G-X-G motif; other site 585055007870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055007871 active site 585055007872 phosphorylation site [posttranslational modification] 585055007873 intermolecular recognition site; other site 585055007874 dimerization interface [polypeptide binding]; other site 585055007875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585055007876 putative binding surface; other site 585055007877 active site 585055007878 putative CoA-transferase; Provisional; Region: PRK11430 585055007879 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585055007880 putative transporter YfdV; Provisional; Region: PRK09903 585055007881 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 585055007882 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585055007883 PYR/PP interface [polypeptide binding]; other site 585055007884 dimer interface [polypeptide binding]; other site 585055007885 TPP binding site [chemical binding]; other site 585055007886 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585055007887 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 585055007888 TPP-binding site; other site 585055007889 dimer interface [polypeptide binding]; other site 585055007890 formyl-coenzyme A transferase; Provisional; Region: PRK05398 585055007891 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585055007892 hypothetical protein; Provisional; Region: PRK10316 585055007893 YfdX protein; Region: YfdX; pfam10938 585055007894 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 585055007895 similar to hypothetical protein; Evidence 4 : Homologs of previously reported genes of unknown function 585055007896 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585055007897 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585055007898 putative acyl-acceptor binding pocket; other site 585055007899 aminotransferase; Validated; Region: PRK08175 585055007900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055007901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055007902 homodimer interface [polypeptide binding]; other site 585055007903 catalytic residue [active] 585055007904 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585055007905 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585055007906 GAF domain; Region: GAF; pfam01590 585055007907 Histidine kinase; Region: His_kinase; pfam06580 585055007908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055007909 ATP binding site [chemical binding]; other site 585055007910 Mg2+ binding site [ion binding]; other site 585055007911 G-X-G motif; other site 585055007912 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 585055007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055007914 active site 585055007915 phosphorylation site [posttranslational modification] 585055007916 intermolecular recognition site; other site 585055007917 dimerization interface [polypeptide binding]; other site 585055007918 LytTr DNA-binding domain; Region: LytTR; pfam04397 585055007919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055007920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055007921 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585055007922 dimerization domain swap beta strand [polypeptide binding]; other site 585055007923 regulatory protein interface [polypeptide binding]; other site 585055007924 active site 585055007925 regulatory phosphorylation site [posttranslational modification]; other site 585055007926 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585055007927 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585055007928 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585055007929 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585055007930 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055007931 active site 585055007932 phosphorylation site [posttranslational modification] 585055007933 exoaminopeptidase; Provisional; Region: PRK09961 585055007934 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 585055007935 oligomer interface [polypeptide binding]; other site 585055007936 active site 585055007937 metal binding site [ion binding]; metal-binding site 585055007938 aminopeptidase; Provisional; Region: PRK09795 585055007939 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 585055007940 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 585055007941 active site 585055007942 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585055007943 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585055007944 active site 585055007945 P-loop; other site 585055007946 phosphorylation site [posttranslational modification] 585055007947 glucokinase, proteobacterial type; Region: glk; TIGR00749 585055007948 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055007949 nucleotide binding site [chemical binding]; other site 585055007950 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585055007951 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585055007952 Cl- selectivity filter; other site 585055007953 Cl- binding residues [ion binding]; other site 585055007954 pore gating glutamate residue; other site 585055007955 dimer interface [polypeptide binding]; other site 585055007956 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585055007957 manganese transport protein MntH; Reviewed; Region: PRK00701 585055007958 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 585055007959 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585055007960 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585055007961 Nucleoside recognition; Region: Gate; pfam07670 585055007962 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585055007963 MASE1; Region: MASE1; pfam05231 585055007964 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055007965 diguanylate cyclase; Region: GGDEF; smart00267 585055007966 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055007967 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 585055007968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055007969 salt bridge; other site 585055007970 non-specific DNA binding site [nucleotide binding]; other site 585055007971 sequence-specific DNA binding site [nucleotide binding]; other site 585055007972 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 585055007973 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585055007974 active site 585055007975 HIGH motif; other site 585055007976 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585055007977 active site 585055007978 KMSKS motif; other site 585055007979 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585055007980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055007981 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 585055007982 putative dimerization interface [polypeptide binding]; other site 585055007983 putative substrate binding pocket [chemical binding]; other site 585055007984 nucleoside transporter; Region: 2A0110; TIGR00889 585055007985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055007986 putative substrate translocation pore; other site 585055007987 purine nucleoside phosphorylase; Provisional; Region: PRK08202 585055007988 hypothetical protein; Provisional; Region: PRK11528 585055007989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055007990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055007991 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585055007992 putative dimerization interface [polypeptide binding]; other site 585055007993 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 585055007994 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 585055007995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 585055007996 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 585055007997 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 585055007998 nucleotide binding pocket [chemical binding]; other site 585055007999 K-X-D-G motif; other site 585055008000 catalytic site [active] 585055008001 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585055008002 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 585055008003 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 585055008004 Dimer interface [polypeptide binding]; other site 585055008005 BRCT sequence motif; other site 585055008006 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 585055008007 cell division protein ZipA; Provisional; Region: PRK03427 585055008008 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 585055008009 FtsZ protein binding site [polypeptide binding]; other site 585055008010 putative sulfate transport protein CysZ; Validated; Region: PRK04949 585055008011 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 585055008012 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585055008013 dimer interface [polypeptide binding]; other site 585055008014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055008015 catalytic residue [active] 585055008016 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585055008017 dimerization domain swap beta strand [polypeptide binding]; other site 585055008018 regulatory protein interface [polypeptide binding]; other site 585055008019 active site 585055008020 regulatory phosphorylation site [posttranslational modification]; other site 585055008021 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 585055008022 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585055008023 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585055008024 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585055008025 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585055008026 HPr interaction site; other site 585055008027 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585055008028 active site 585055008029 phosphorylation site [posttranslational modification] 585055008030 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585055008031 dimer interface [polypeptide binding]; other site 585055008032 pyridoxamine kinase; Validated; Region: PRK05756 585055008033 pyridoxal binding site [chemical binding]; other site 585055008034 ATP binding site [chemical binding]; other site 585055008035 hypothetical protein; Provisional; Region: PRK10318 585055008036 cysteine synthase B; Region: cysM; TIGR01138 585055008037 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585055008038 dimer interface [polypeptide binding]; other site 585055008039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055008040 catalytic residue [active] 585055008041 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 585055008042 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 585055008043 Walker A/P-loop; other site 585055008044 ATP binding site [chemical binding]; other site 585055008045 Q-loop/lid; other site 585055008046 ABC transporter signature motif; other site 585055008047 Walker B; other site 585055008048 D-loop; other site 585055008049 H-loop/switch region; other site 585055008050 TOBE-like domain; Region: TOBE_3; pfam12857 585055008051 sulfate transport protein; Provisional; Region: cysT; CHL00187 585055008052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055008053 dimer interface [polypeptide binding]; other site 585055008054 conserved gate region; other site 585055008055 putative PBP binding loops; other site 585055008056 ABC-ATPase subunit interface; other site 585055008057 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585055008058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055008059 dimer interface [polypeptide binding]; other site 585055008060 conserved gate region; other site 585055008061 putative PBP binding loops; other site 585055008062 ABC-ATPase subunit interface; other site 585055008063 thiosulfate transporter subunit; Provisional; Region: PRK10852 585055008064 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585055008065 short chain dehydrogenase; Provisional; Region: PRK08226 585055008066 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 585055008067 NAD binding site [chemical binding]; other site 585055008068 homotetramer interface [polypeptide binding]; other site 585055008069 homodimer interface [polypeptide binding]; other site 585055008070 active site 585055008071 transcriptional regulator MurR; Provisional; Region: PRK15482 585055008072 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585055008073 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585055008074 putative active site [active] 585055008075 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 585055008076 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 585055008077 putative active site [active] 585055008078 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 585055008079 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055008080 active site turn [active] 585055008081 phosphorylation site [posttranslational modification] 585055008082 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585055008083 putative periplasmic esterase; Provisional; Region: PRK03642 585055008084 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585055008085 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 585055008086 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 585055008087 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 585055008088 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 585055008089 putative acetyltransferase; Provisional; Region: PRK03624 585055008090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055008091 Coenzyme A binding pocket [chemical binding]; other site 585055008092 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 585055008093 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585055008094 active site 585055008095 metal binding site [ion binding]; metal-binding site 585055008096 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 585055008097 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 585055008098 transcriptional regulator EutR; Provisional; Region: PRK10130 585055008099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055008100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055008101 carboxysome structural protein EutK; Provisional; Region: PRK15466 585055008102 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585055008103 Hexamer interface [polypeptide binding]; other site 585055008104 Hexagonal pore residue; other site 585055008105 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 585055008106 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 585055008107 putative hexamer interface [polypeptide binding]; other site 585055008108 putative hexagonal pore; other site 585055008109 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 585055008110 putative hexamer interface [polypeptide binding]; other site 585055008111 putative hexagonal pore; other site 585055008112 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 585055008113 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 585055008114 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 585055008115 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 585055008116 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 585055008117 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 585055008118 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 585055008119 active site 585055008120 metal binding site [ion binding]; metal-binding site 585055008121 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 585055008122 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055008123 nucleotide binding site [chemical binding]; other site 585055008124 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 585055008125 putative catalytic cysteine [active] 585055008126 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 585055008127 Hexamer/Pentamer interface [polypeptide binding]; other site 585055008128 central pore; other site 585055008129 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585055008130 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 585055008131 Hexamer interface [polypeptide binding]; other site 585055008132 Putative hexagonal pore residue; other site 585055008133 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 585055008134 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 585055008135 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 585055008136 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 585055008137 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585055008138 G1 box; other site 585055008139 GTP/Mg2+ binding site [chemical binding]; other site 585055008140 G2 box; other site 585055008141 Switch I region; other site 585055008142 G3 box; other site 585055008143 Switch II region; other site 585055008144 G4 box; other site 585055008145 G5 box; other site 585055008146 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 585055008147 putative hexamer interface [polypeptide binding]; other site 585055008148 putative hexagonal pore; other site 585055008149 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 585055008150 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585055008151 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 585055008152 putative NAD(P) binding site [chemical binding]; other site 585055008153 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 585055008154 transaldolase-like protein; Provisional; Region: PTZ00411 585055008155 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585055008156 active site 585055008157 dimer interface [polypeptide binding]; other site 585055008158 catalytic residue [active] 585055008159 transketolase; Reviewed; Region: PRK12753 585055008160 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585055008161 TPP-binding site [chemical binding]; other site 585055008162 dimer interface [polypeptide binding]; other site 585055008163 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585055008164 PYR/PP interface [polypeptide binding]; other site 585055008165 dimer interface [polypeptide binding]; other site 585055008166 TPP binding site [chemical binding]; other site 585055008167 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585055008168 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 585055008169 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 585055008170 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585055008171 dimer interface [polypeptide binding]; other site 585055008172 ADP-ribose binding site [chemical binding]; other site 585055008173 active site 585055008174 nudix motif; other site 585055008175 metal binding site [ion binding]; metal-binding site 585055008176 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 585055008177 4Fe-4S binding domain; Region: Fer4; pfam00037 585055008178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055008179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055008180 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 585055008181 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585055008182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055008183 dimerization interface [polypeptide binding]; other site 585055008184 Histidine kinase; Region: HisKA_3; pfam07730 585055008185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055008186 ATP binding site [chemical binding]; other site 585055008187 Mg2+ binding site [ion binding]; other site 585055008188 G-X-G motif; other site 585055008189 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 585055008190 Protein export membrane protein; Region: SecD_SecF; cl14618 585055008191 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 585055008192 ArsC family; Region: ArsC; pfam03960 585055008193 putative catalytic residues [active] 585055008194 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 585055008195 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 585055008196 metal binding site [ion binding]; metal-binding site 585055008197 dimer interface [polypeptide binding]; other site 585055008198 hypothetical protein; Provisional; Region: PRK13664 585055008199 putative hydrolase; Provisional; Region: PRK11460 585055008200 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 585055008201 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 585055008202 Helicase; Region: Helicase_RecD; pfam05127 585055008203 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 585055008204 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 585055008205 Predicted metalloprotease [General function prediction only]; Region: COG2321 585055008206 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 585055008207 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 585055008208 oligomeric interface; other site 585055008209 putative active site [active] 585055008210 homodimer interface [polypeptide binding]; other site 585055008211 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 585055008212 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 585055008213 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 585055008214 ATP binding site [chemical binding]; other site 585055008215 active site 585055008216 substrate binding site [chemical binding]; other site 585055008217 lipoprotein; Provisional; Region: PRK11679 585055008218 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 585055008219 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 585055008220 dihydrodipicolinate synthase; Region: dapA; TIGR00674 585055008221 dimer interface [polypeptide binding]; other site 585055008222 active site 585055008223 catalytic residue [active] 585055008224 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 585055008225 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 585055008226 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585055008227 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 585055008228 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 585055008229 catalytic triad [active] 585055008230 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585055008231 4Fe-4S binding domain; Region: Fer4; pfam00037 585055008232 hydrogenase 4 subunit B; Validated; Region: PRK06521 585055008233 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585055008234 fragment of hydrogenase 4, membrane subunit (part 1);Evidence 7 : Gene remnant; Product type m : membrane component 585055008235 fragment of hydrogenase 4, membrane subunit (part 2);Evidence 7 : Gene remnant; Product type m : membrane component 585055008236 fragment of hydrogenase 4, membrane subunit (part 1);Evidence 7 : Gene remnant; Product type m : membrane component 585055008237 fragment of hydrogenase 4, membrane subunit (part 2);Evidence 7 : Gene remnant; Product type m : membrane component 585055008238 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 585055008239 hydrogenase 4 subunit F; Validated; Region: PRK06458 585055008240 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585055008241 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585055008242 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585055008243 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585055008244 hydrogenase 4 subunit H; Validated; Region: PRK08222 585055008245 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055008246 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 585055008247 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585055008248 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 585055008249 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585055008250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055008251 Walker A motif; other site 585055008252 ATP binding site [chemical binding]; other site 585055008253 Walker B motif; other site 585055008254 arginine finger; other site 585055008255 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585055008256 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 585055008257 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 585055008258 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585055008259 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 585055008260 Peptidase family M48; Region: Peptidase_M48; cl12018 585055008261 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585055008262 ArsC family; Region: ArsC; pfam03960 585055008263 catalytic residues [active] 585055008264 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 585055008265 DNA replication initiation factor; Provisional; Region: PRK08084 585055008266 uracil transporter; Provisional; Region: PRK10720 585055008267 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055008268 active site 585055008269 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 585055008270 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 585055008271 dimerization interface [polypeptide binding]; other site 585055008272 putative ATP binding site [chemical binding]; other site 585055008273 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 585055008274 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 585055008275 active site 585055008276 substrate binding site [chemical binding]; other site 585055008277 cosubstrate binding site; other site 585055008278 catalytic site [active] 585055008279 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 585055008280 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 585055008281 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 585055008282 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 585055008283 domain interface [polypeptide binding]; other site 585055008284 active site 585055008285 catalytic site [active] 585055008286 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 585055008287 putative active site [active] 585055008288 catalytic site [active] 585055008289 exopolyphosphatase; Provisional; Region: PRK10854 585055008290 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585055008291 MASE1; Region: MASE1; pfam05231 585055008292 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585055008293 diguanylate cyclase; Region: GGDEF; smart00267 585055008294 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055008295 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 585055008296 GMP synthase; Reviewed; Region: guaA; PRK00074 585055008297 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 585055008298 AMP/PPi binding site [chemical binding]; other site 585055008299 candidate oxyanion hole; other site 585055008300 catalytic triad [active] 585055008301 potential glutamine specificity residues [chemical binding]; other site 585055008302 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 585055008303 ATP Binding subdomain [chemical binding]; other site 585055008304 Ligand Binding sites [chemical binding]; other site 585055008305 Dimerization subdomain; other site 585055008306 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 585055008307 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585055008308 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 585055008309 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585055008310 active site 585055008311 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 585055008312 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 585055008313 generic binding surface II; other site 585055008314 generic binding surface I; other site 585055008315 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 585055008316 GTP-binding protein Der; Reviewed; Region: PRK00093 585055008317 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 585055008318 G1 box; other site 585055008319 GTP/Mg2+ binding site [chemical binding]; other site 585055008320 Switch I region; other site 585055008321 G2 box; other site 585055008322 Switch II region; other site 585055008323 G3 box; other site 585055008324 G4 box; other site 585055008325 G5 box; other site 585055008326 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 585055008327 G1 box; other site 585055008328 GTP/Mg2+ binding site [chemical binding]; other site 585055008329 Switch I region; other site 585055008330 G2 box; other site 585055008331 G3 box; other site 585055008332 Switch II region; other site 585055008333 G4 box; other site 585055008334 G5 box; other site 585055008335 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 585055008336 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 585055008337 Trp docking motif [polypeptide binding]; other site 585055008338 active site 585055008339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 585055008340 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 585055008341 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 585055008342 dimer interface [polypeptide binding]; other site 585055008343 motif 1; other site 585055008344 active site 585055008345 motif 2; other site 585055008346 motif 3; other site 585055008347 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 585055008348 anticodon binding site; other site 585055008349 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 585055008350 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585055008351 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585055008352 cytoskeletal protein RodZ; Provisional; Region: PRK10856 585055008353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055008354 non-specific DNA binding site [nucleotide binding]; other site 585055008355 salt bridge; other site 585055008356 sequence-specific DNA binding site [nucleotide binding]; other site 585055008357 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 585055008358 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 585055008359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055008360 FeS/SAM binding site; other site 585055008361 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 585055008362 active site 585055008363 multimer interface [polypeptide binding]; other site 585055008364 penicillin-binding protein 1C; Provisional; Region: PRK11240 585055008365 Transglycosylase; Region: Transgly; pfam00912 585055008366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585055008367 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 585055008368 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585055008369 MG2 domain; Region: A2M_N; pfam01835 585055008370 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585055008371 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 585055008372 surface patch; other site 585055008373 thioester region; other site 585055008374 specificity defining residues; other site 585055008375 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 585055008376 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585055008377 active site residue [active] 585055008378 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585055008379 active site residue [active] 585055008380 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 585055008381 aminopeptidase B; Provisional; Region: PRK05015 585055008382 Peptidase; Region: DUF3663; pfam12404 585055008383 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585055008384 interface (dimer of trimers) [polypeptide binding]; other site 585055008385 Substrate-binding/catalytic site; other site 585055008386 Zn-binding sites [ion binding]; other site 585055008387 hypothetical protein; Provisional; Region: PRK10721 585055008388 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585055008389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055008390 catalytic loop [active] 585055008391 iron binding site [ion binding]; other site 585055008392 chaperone protein HscA; Provisional; Region: hscA; PRK05183 585055008393 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 585055008394 nucleotide binding site [chemical binding]; other site 585055008395 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585055008396 SBD interface [polypeptide binding]; other site 585055008397 co-chaperone HscB; Provisional; Region: hscB; PRK05014 585055008398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585055008399 HSP70 interaction site [polypeptide binding]; other site 585055008400 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 585055008401 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 585055008402 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 585055008403 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 585055008404 trimerization site [polypeptide binding]; other site 585055008405 active site 585055008406 cysteine desulfurase; Provisional; Region: PRK14012 585055008407 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 585055008408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585055008409 catalytic residue [active] 585055008410 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 585055008411 Rrf2 family protein; Region: rrf2_super; TIGR00738 585055008412 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 585055008413 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 585055008414 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585055008415 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 585055008416 active site 585055008417 dimerization interface [polypeptide binding]; other site 585055008418 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585055008419 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585055008420 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 585055008421 PRD domain; Region: PRD; pfam00874 585055008422 PRD domain; Region: PRD; pfam00874 585055008423 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 585055008424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055008425 putative substrate translocation pore; other site 585055008426 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 585055008427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055008428 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 585055008429 putative dimerization interface [polypeptide binding]; other site 585055008430 putative substrate binding pocket [chemical binding]; other site 585055008431 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 585055008432 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 585055008433 iron-sulfur cluster [ion binding]; other site 585055008434 [2Fe-2S] cluster binding site [ion binding]; other site 585055008435 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 585055008436 beta subunit interface [polypeptide binding]; other site 585055008437 alpha subunit interface [polypeptide binding]; other site 585055008438 active site 585055008439 substrate binding site [chemical binding]; other site 585055008440 Fe binding site [ion binding]; other site 585055008441 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 585055008442 inter-subunit interface; other site 585055008443 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 585055008444 [2Fe-2S] cluster binding site [ion binding]; other site 585055008445 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 585055008446 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 585055008447 NAD binding site [chemical binding]; other site 585055008448 active site 585055008449 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 585055008450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055008451 Predicted membrane protein [Function unknown]; Region: COG2259 585055008452 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 585055008453 active site 585055008454 catalytic residues [active] 585055008455 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585055008456 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 585055008457 putative NAD(P) binding site [chemical binding]; other site 585055008458 catalytic Zn binding site [ion binding]; other site 585055008459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055008460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055008461 TM-ABC transporter signature motif; other site 585055008462 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585055008463 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055008464 Walker A/P-loop; other site 585055008465 ATP binding site [chemical binding]; other site 585055008466 Q-loop/lid; other site 585055008467 ABC transporter signature motif; other site 585055008468 Walker B; other site 585055008469 D-loop; other site 585055008470 H-loop/switch region; other site 585055008471 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055008472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 585055008473 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 585055008474 ligand binding site [chemical binding]; other site 585055008475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055008476 TPR motif; other site 585055008477 Tetratricopeptide repeat; Region: TPR_16; pfam13432 585055008478 binding surface 585055008479 TPR repeat; Region: TPR_11; pfam13414 585055008480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055008481 TPR motif; other site 585055008482 binding surface 585055008483 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 585055008484 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585055008485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055008486 nucleotide binding site [chemical binding]; other site 585055008487 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 585055008488 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 585055008489 dimer interface [polypeptide binding]; other site 585055008490 active site 585055008491 glycine-pyridoxal phosphate binding site [chemical binding]; other site 585055008492 folate binding site [chemical binding]; other site 585055008493 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 585055008494 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 585055008495 heme-binding site [chemical binding]; other site 585055008496 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 585055008497 FAD binding pocket [chemical binding]; other site 585055008498 FAD binding motif [chemical binding]; other site 585055008499 phosphate binding motif [ion binding]; other site 585055008500 beta-alpha-beta structure motif; other site 585055008501 NAD binding pocket [chemical binding]; other site 585055008502 Heme binding pocket [chemical binding]; other site 585055008503 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 585055008504 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585055008505 response regulator GlrR; Provisional; Region: PRK15115 585055008506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055008507 active site 585055008508 phosphorylation site [posttranslational modification] 585055008509 intermolecular recognition site; other site 585055008510 dimerization interface [polypeptide binding]; other site 585055008511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055008512 Walker A motif; other site 585055008513 ATP binding site [chemical binding]; other site 585055008514 Walker B motif; other site 585055008515 arginine finger; other site 585055008516 hypothetical protein; Provisional; Region: PRK10722 585055008517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 585055008518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055008519 dimer interface [polypeptide binding]; other site 585055008520 phosphorylation site [posttranslational modification] 585055008521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055008522 ATP binding site [chemical binding]; other site 585055008523 Mg2+ binding site [ion binding]; other site 585055008524 G-X-G motif; other site 585055008525 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 585055008526 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 585055008527 dimerization interface [polypeptide binding]; other site 585055008528 ATP binding site [chemical binding]; other site 585055008529 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 585055008530 dimerization interface [polypeptide binding]; other site 585055008531 ATP binding site [chemical binding]; other site 585055008532 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 585055008533 putative active site [active] 585055008534 catalytic triad [active] 585055008535 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 585055008536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055008537 substrate binding pocket [chemical binding]; other site 585055008538 membrane-bound complex binding site; other site 585055008539 hinge residues; other site 585055008540 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585055008541 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585055008542 catalytic residue [active] 585055008543 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 585055008544 nucleoside/Zn binding site; other site 585055008545 dimer interface [polypeptide binding]; other site 585055008546 catalytic motif [active] 585055008547 hypothetical protein; Provisional; Region: PRK11590 585055008548 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 585055008549 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585055008550 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 585055008551 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585055008552 putative active site [active] 585055008553 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 585055008554 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 585055008555 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 585055008556 active site 585055008557 hydrophilic channel; other site 585055008558 dimerization interface [polypeptide binding]; other site 585055008559 catalytic residues [active] 585055008560 active site lid [active] 585055008561 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 585055008562 Recombination protein O N terminal; Region: RecO_N; pfam11967 585055008563 Recombination protein O C terminal; Region: RecO_C; pfam02565 585055008564 GTPase Era; Reviewed; Region: era; PRK00089 585055008565 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 585055008566 G1 box; other site 585055008567 GTP/Mg2+ binding site [chemical binding]; other site 585055008568 Switch I region; other site 585055008569 G2 box; other site 585055008570 Switch II region; other site 585055008571 G3 box; other site 585055008572 G4 box; other site 585055008573 G5 box; other site 585055008574 KH domain; Region: KH_2; pfam07650 585055008575 ribonuclease III; Reviewed; Region: rnc; PRK00102 585055008576 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 585055008577 dimerization interface [polypeptide binding]; other site 585055008578 active site 585055008579 metal binding site [ion binding]; metal-binding site 585055008580 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 585055008581 dsRNA binding site [nucleotide binding]; other site 585055008582 signal peptidase I; Provisional; Region: PRK10861 585055008583 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585055008584 Catalytic site [active] 585055008585 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585055008586 GTP-binding protein LepA; Provisional; Region: PRK05433 585055008587 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 585055008588 G1 box; other site 585055008589 putative GEF interaction site [polypeptide binding]; other site 585055008590 GTP/Mg2+ binding site [chemical binding]; other site 585055008591 Switch I region; other site 585055008592 G2 box; other site 585055008593 G3 box; other site 585055008594 Switch II region; other site 585055008595 G4 box; other site 585055008596 G5 box; other site 585055008597 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 585055008598 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 585055008599 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 585055008600 SoxR reducing system protein RseC; Provisional; Region: PRK10862 585055008601 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 585055008602 anti-sigma E factor; Provisional; Region: rseB; PRK09455 585055008603 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 585055008604 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 585055008605 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 585055008606 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 585055008607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585055008608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585055008609 DNA binding residues [nucleotide binding] 585055008610 L-aspartate oxidase; Provisional; Region: PRK09077 585055008611 L-aspartate oxidase; Provisional; Region: PRK06175 585055008612 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585055008613 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 585055008614 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585055008615 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 585055008616 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585055008617 ATP binding site [chemical binding]; other site 585055008618 Mg++ binding site [ion binding]; other site 585055008619 motif III; other site 585055008620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055008621 nucleotide binding region [chemical binding]; other site 585055008622 ATP-binding site [chemical binding]; other site 585055008623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055008624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055008625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585055008626 dimerization interface [polypeptide binding]; other site 585055008627 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 585055008628 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 585055008629 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 585055008630 ligand binding site [chemical binding]; other site 585055008631 active site 585055008632 UGI interface [polypeptide binding]; other site 585055008633 catalytic site [active] 585055008634 putative methyltransferase; Provisional; Region: PRK10864 585055008635 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 585055008636 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585055008637 thioredoxin 2; Provisional; Region: PRK10996 585055008638 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 585055008639 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585055008640 catalytic residues [active] 585055008641 Uncharacterized conserved protein [Function unknown]; Region: COG3148 585055008642 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 585055008643 CoA binding domain; Region: CoA_binding_2; pfam13380 585055008644 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 585055008645 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 585055008646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 585055008647 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585055008648 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 585055008649 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 585055008650 domain interface [polypeptide binding]; other site 585055008651 putative active site [active] 585055008652 catalytic site [active] 585055008653 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 585055008654 domain interface [polypeptide binding]; other site 585055008655 putative active site [active] 585055008656 catalytic site [active] 585055008657 lipoprotein; Provisional; Region: PRK10759 585055008658 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 585055008659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055008660 putative substrate translocation pore; other site 585055008661 protein disaggregation chaperone; Provisional; Region: PRK10865 585055008662 Clp amino terminal domain; Region: Clp_N; pfam02861 585055008663 Clp amino terminal domain; Region: Clp_N; pfam02861 585055008664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055008665 Walker A motif; other site 585055008666 ATP binding site [chemical binding]; other site 585055008667 Walker B motif; other site 585055008668 arginine finger; other site 585055008669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055008670 Walker A motif; other site 585055008671 ATP binding site [chemical binding]; other site 585055008672 Walker B motif; other site 585055008673 arginine finger; other site 585055008674 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585055008675 hypothetical protein; Provisional; Region: PRK10723 585055008676 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 585055008677 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 585055008678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055008679 RNA binding surface [nucleotide binding]; other site 585055008680 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585055008681 active site 585055008682 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 585055008683 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 585055008684 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585055008685 30S subunit binding site; other site 585055008686 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 585055008687 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 585055008688 Prephenate dehydratase; Region: PDT; pfam00800 585055008689 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 585055008690 putative L-Phe binding site [chemical binding]; other site 585055008691 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 585055008692 Chorismate mutase type II; Region: CM_2; cl00693 585055008693 prephenate dehydrogenase; Validated; Region: PRK08507 585055008694 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 585055008695 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585055008696 lipoprotein; Provisional; Region: PRK11443 585055008697 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 585055008698 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 585055008699 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 585055008700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055008701 metal binding site [ion binding]; metal-binding site 585055008702 active site 585055008703 I-site; other site 585055008704 putative outer membrane lipoprotein; Provisional; Region: PRK09967 585055008705 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585055008706 ligand binding site [chemical binding]; other site 585055008707 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 585055008708 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 585055008709 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 585055008710 RimM N-terminal domain; Region: RimM; pfam01782 585055008711 PRC-barrel domain; Region: PRC; pfam05239 585055008712 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 585055008713 signal recognition particle protein; Provisional; Region: PRK10867 585055008714 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 585055008715 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585055008716 P loop; other site 585055008717 GTP binding site [chemical binding]; other site 585055008718 Signal peptide binding domain; Region: SRP_SPB; pfam02978 585055008719 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 585055008720 hypothetical protein; Provisional; Region: PRK11573 585055008721 Domain of unknown function DUF21; Region: DUF21; pfam01595 585055008722 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585055008723 Transporter associated domain; Region: CorC_HlyC; smart01091 585055008724 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 585055008725 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 585055008726 dimer interface [polypeptide binding]; other site 585055008727 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 585055008728 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 585055008729 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 585055008730 recombination and repair protein; Provisional; Region: PRK10869 585055008731 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585055008732 Walker A/P-loop; other site 585055008733 ATP binding site [chemical binding]; other site 585055008734 Q-loop/lid; other site 585055008735 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585055008736 Q-loop/lid; other site 585055008737 ABC transporter signature motif; other site 585055008738 Walker B; other site 585055008739 D-loop; other site 585055008740 H-loop/switch region; other site 585055008741 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 585055008742 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 585055008743 hypothetical protein; Validated; Region: PRK01777 585055008744 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 585055008745 putative coenzyme Q binding site [chemical binding]; other site 585055008746 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 585055008747 SmpB-tmRNA interface; other site 585055008748 integrase; Provisional; Region: PRK09692 585055008749 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585055008750 active site 585055008751 Int/Topo IB signature motif; other site 585055008752 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585055008753 G1 box; other site 585055008754 GTP/Mg2+ binding site [chemical binding]; other site 585055008755 G2 box; other site 585055008756 Switch I region; other site 585055008757 G3 box; other site 585055008758 Switch II region; other site 585055008759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055008760 Transposase; Region: HTH_Tnp_1; cl17663 585055008761 fragment of transposase ORF B, IS3 family (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055008762 fragment of invertase fragment (fragment) (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055008763 fragment of conserved hypothetical protein from bacteriophage origin (part 2);Evidence 7 : Gene remnant 585055008764 fragment of conserved hypothetical protein from bacteriophage origin (part 1);Evidence 7 : Gene remnant 585055008765 fragment of Alpha-amylase (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055008766 fragment of Alpha-amylase (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055008767 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 585055008768 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 585055008769 substrate binding pocket [chemical binding]; other site 585055008770 active site 585055008771 iron coordination sites [ion binding]; other site 585055008772 Predicted dehydrogenase [General function prediction only]; Region: COG0579 585055008773 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585055008774 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 585055008775 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 585055008776 tetramerization interface [polypeptide binding]; other site 585055008777 NAD(P) binding site [chemical binding]; other site 585055008778 catalytic residues [active] 585055008779 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 585055008780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585055008781 inhibitor-cofactor binding pocket; inhibition site 585055008782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055008783 catalytic residue [active] 585055008784 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 585055008785 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 585055008786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055008787 DNA-binding site [nucleotide binding]; DNA binding site 585055008788 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585055008789 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 585055008790 bacterial OsmY and nodulation domain; Region: BON; smart00749 585055008791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055008792 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 585055008793 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055008794 dimerization interface [polypeptide binding]; other site 585055008795 putative DNA binding site [nucleotide binding]; other site 585055008796 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585055008797 putative Zn2+ binding site [ion binding]; other site 585055008798 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 585055008799 active site residue [active] 585055008800 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 585055008801 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 585055008802 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585055008803 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 585055008804 hypothetical protein; Provisional; Region: PRK10556 585055008805 hypothetical protein; Provisional; Region: PRK10132 585055008806 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 585055008807 catalytic residues [active] 585055008808 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 585055008809 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 585055008810 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 585055008811 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585055008812 active site 585055008813 dimer interface [polypeptide binding]; other site 585055008814 catalytic residues [active] 585055008815 effector binding site; other site 585055008816 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 585055008817 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 585055008818 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585055008819 dimer interface [polypeptide binding]; other site 585055008820 putative radical transfer pathway; other site 585055008821 diiron center [ion binding]; other site 585055008822 tyrosyl radical; other site 585055008823 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 585055008824 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 585055008825 Walker A/P-loop; other site 585055008826 ATP binding site [chemical binding]; other site 585055008827 Q-loop/lid; other site 585055008828 ABC transporter signature motif; other site 585055008829 Walker B; other site 585055008830 D-loop; other site 585055008831 H-loop/switch region; other site 585055008832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 585055008833 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 585055008834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055008835 dimer interface [polypeptide binding]; other site 585055008836 conserved gate region; other site 585055008837 putative PBP binding loops; other site 585055008838 ABC-ATPase subunit interface; other site 585055008839 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 585055008840 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 585055008841 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585055008842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055008843 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 585055008844 putative L-valine exporter; Provisional; Region: PRK10408 585055008845 transcriptional repressor MprA; Provisional; Region: PRK10870 585055008846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585055008847 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 585055008848 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055008849 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055008850 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585055008851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055008852 putative substrate translocation pore; other site 585055008853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055008854 S-ribosylhomocysteinase; Provisional; Region: PRK02260 585055008855 glutamate--cysteine ligase; Provisional; Region: PRK02107 585055008856 Predicted membrane protein [Function unknown]; Region: COG1238 585055008857 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 585055008858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055008859 motif II; other site 585055008860 carbon storage regulator; Provisional; Region: PRK01712 585055008861 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 585055008862 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 585055008863 motif 1; other site 585055008864 active site 585055008865 motif 2; other site 585055008866 motif 3; other site 585055008867 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 585055008868 DHHA1 domain; Region: DHHA1; pfam02272 585055008869 recombination regulator RecX; Reviewed; Region: recX; PRK00117 585055008870 recombinase A; Provisional; Region: recA; PRK09354 585055008871 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 585055008872 hexamer interface [polypeptide binding]; other site 585055008873 Walker A motif; other site 585055008874 ATP binding site [chemical binding]; other site 585055008875 Walker B motif; other site 585055008876 hypothetical protein; Validated; Region: PRK03661 585055008877 Transglycosylase SLT domain; Region: SLT_2; pfam13406 585055008878 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585055008879 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585055008880 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 585055008881 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 585055008882 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 585055008883 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 585055008884 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 585055008885 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 585055008886 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 585055008887 putative NAD(P) binding site [chemical binding]; other site 585055008888 active site 585055008889 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 585055008890 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 585055008891 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585055008892 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055008893 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 585055008894 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585055008895 putative active site [active] 585055008896 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585055008897 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 585055008898 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585055008899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055008900 Walker A motif; other site 585055008901 ATP binding site [chemical binding]; other site 585055008902 Walker B motif; other site 585055008903 arginine finger; other site 585055008904 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 585055008905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585055008906 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 585055008907 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 585055008908 iron binding site [ion binding]; other site 585055008909 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 585055008910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055008911 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 585055008912 Acylphosphatase; Region: Acylphosphatase; pfam00708 585055008913 HypF finger; Region: zf-HYPF; pfam07503 585055008914 HypF finger; Region: zf-HYPF; pfam07503 585055008915 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 585055008916 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 585055008917 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585055008918 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585055008919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055008920 DNA binding site [nucleotide binding] 585055008921 domain linker motif; other site 585055008922 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585055008923 dimerization interface (closed form) [polypeptide binding]; other site 585055008924 ligand binding site [chemical binding]; other site 585055008925 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 585055008926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055008927 active site turn [active] 585055008928 phosphorylation site [posttranslational modification] 585055008929 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585055008930 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 585055008931 beta-galactosidase; Region: BGL; TIGR03356 585055008932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055008933 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055008934 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055008935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055008936 non-specific DNA binding site [nucleotide binding]; other site 585055008937 salt bridge; other site 585055008938 sequence-specific DNA binding site [nucleotide binding]; other site 585055008939 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 585055008940 nickel binding site [ion binding]; other site 585055008941 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585055008942 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 585055008943 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 585055008944 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055008945 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585055008946 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585055008947 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585055008948 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585055008949 NADH dehydrogenase; Region: NADHdh; cl00469 585055008950 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 585055008951 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585055008952 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585055008953 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 585055008954 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 585055008955 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 585055008956 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 585055008957 hydrogenase assembly chaperone; Provisional; Region: PRK10409 585055008958 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 585055008959 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 585055008960 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 585055008961 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 585055008962 dimerization interface [polypeptide binding]; other site 585055008963 ATP binding site [chemical binding]; other site 585055008964 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 585055008965 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585055008966 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585055008967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055008968 Walker A motif; other site 585055008969 ATP binding site [chemical binding]; other site 585055008970 Walker B motif; other site 585055008971 arginine finger; other site 585055008972 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 585055008973 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 585055008974 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 585055008975 MutS domain I; Region: MutS_I; pfam01624 585055008976 MutS domain II; Region: MutS_II; pfam05188 585055008977 MutS domain III; Region: MutS_III; pfam05192 585055008978 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 585055008979 Walker A/P-loop; other site 585055008980 ATP binding site [chemical binding]; other site 585055008981 Q-loop/lid; other site 585055008982 ABC transporter signature motif; other site 585055008983 Walker B; other site 585055008984 D-loop; other site 585055008985 H-loop/switch region; other site 585055008986 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585055008987 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585055008988 active site 585055008989 metal binding site [ion binding]; metal-binding site 585055008990 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585055008991 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585055008992 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055008993 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 585055008994 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585055008995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 585055008996 putative aldolase; Validated; Region: PRK08130 585055008997 active site 585055008998 intersubunit interface [polypeptide binding]; other site 585055008999 Zn2+ binding site [ion binding]; other site 585055009000 hypothetical protein; Provisional; Region: PRK09989 585055009001 putative transporter; Provisional; Region: PRK09821 585055009002 GntP family permease; Region: GntP_permease; pfam02447 585055009003 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 585055009004 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 585055009005 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 585055009006 Flavoprotein; Region: Flavoprotein; pfam02441 585055009007 MarR family; Region: MarR_2; cl17246 585055009008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585055009009 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 585055009010 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585055009011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585055009012 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585055009013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585055009014 DNA binding residues [nucleotide binding] 585055009015 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 585055009016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055009017 Peptidase family M23; Region: Peptidase_M23; pfam01551 585055009018 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 585055009019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055009020 S-adenosylmethionine binding site [chemical binding]; other site 585055009021 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 585055009022 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 585055009023 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 585055009024 Permutation of conserved domain; other site 585055009025 active site 585055009026 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 585055009027 homotrimer interaction site [polypeptide binding]; other site 585055009028 zinc binding site [ion binding]; other site 585055009029 CDP-binding sites; other site 585055009030 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 585055009031 substrate binding site; other site 585055009032 dimer interface; other site 585055009033 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 585055009034 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 585055009035 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 585055009036 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 585055009037 ligand-binding site [chemical binding]; other site 585055009038 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 585055009039 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 585055009040 CysD dimerization site [polypeptide binding]; other site 585055009041 G1 box; other site 585055009042 putative GEF interaction site [polypeptide binding]; other site 585055009043 GTP/Mg2+ binding site [chemical binding]; other site 585055009044 Switch I region; other site 585055009045 G2 box; other site 585055009046 G3 box; other site 585055009047 Switch II region; other site 585055009048 G4 box; other site 585055009049 G5 box; other site 585055009050 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 585055009051 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 585055009052 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 585055009053 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585055009054 Active Sites [active] 585055009055 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 585055009056 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 585055009057 metal binding site [ion binding]; metal-binding site 585055009058 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 585055009059 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 585055009060 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 585055009061 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 585055009062 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 585055009063 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 585055009064 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 585055009065 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 585055009066 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 585055009067 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 585055009068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585055009069 Hok/gef family; Region: HOK_GEF; pfam01848 585055009070 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 585055009071 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585055009072 Active Sites [active] 585055009073 sulfite reductase subunit beta; Provisional; Region: PRK13504 585055009074 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585055009075 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585055009076 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 585055009077 Flavodoxin; Region: Flavodoxin_1; pfam00258 585055009078 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 585055009079 FAD binding pocket [chemical binding]; other site 585055009080 FAD binding motif [chemical binding]; other site 585055009081 catalytic residues [active] 585055009082 NAD binding pocket [chemical binding]; other site 585055009083 phosphate binding motif [ion binding]; other site 585055009084 beta-alpha-beta structure motif; other site 585055009085 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 585055009086 homohexamer interface [polypeptide binding]; other site 585055009087 putative substrate stabilizing pore; other site 585055009088 pterin binding site; other site 585055009089 putative oxidoreductase FixC; Provisional; Region: PRK10157 585055009090 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585055009091 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 585055009092 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 585055009093 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 585055009094 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585055009095 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585055009096 Ligand binding site [chemical binding]; other site 585055009097 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585055009098 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 585055009099 benzoate transport; Region: 2A0115; TIGR00895 585055009100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009101 putative substrate translocation pore; other site 585055009102 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585055009103 FAD binding domain; Region: FAD_binding_4; pfam01565 585055009104 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 585055009105 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585055009106 NADP binding site [chemical binding]; other site 585055009107 homodimer interface [polypeptide binding]; other site 585055009108 active site 585055009109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055009110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009111 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585055009112 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585055009113 nucleotide binding site [chemical binding]; other site 585055009114 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 585055009115 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 585055009116 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585055009117 Repair protein; Region: Repair_PSII; pfam04536 585055009118 enolase; Provisional; Region: eno; PRK00077 585055009119 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 585055009120 dimer interface [polypeptide binding]; other site 585055009121 metal binding site [ion binding]; metal-binding site 585055009122 substrate binding pocket [chemical binding]; other site 585055009123 CTP synthetase; Validated; Region: pyrG; PRK05380 585055009124 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 585055009125 Catalytic site [active] 585055009126 active site 585055009127 UTP binding site [chemical binding]; other site 585055009128 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 585055009129 active site 585055009130 putative oxyanion hole; other site 585055009131 catalytic triad [active] 585055009132 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 585055009133 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 585055009134 homodimer interface [polypeptide binding]; other site 585055009135 metal binding site [ion binding]; metal-binding site 585055009136 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 585055009137 homodimer interface [polypeptide binding]; other site 585055009138 active site 585055009139 putative chemical substrate binding site [chemical binding]; other site 585055009140 metal binding site [ion binding]; metal-binding site 585055009141 toxin MazF; Provisional; Region: PRK09907 585055009142 antitoxin MazE; Provisional; Region: PRK09798 585055009143 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 585055009144 HD domain; Region: HD_4; pfam13328 585055009145 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585055009146 synthetase active site [active] 585055009147 NTP binding site [chemical binding]; other site 585055009148 metal binding site [ion binding]; metal-binding site 585055009149 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585055009150 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585055009151 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 585055009152 TRAM domain; Region: TRAM; pfam01938 585055009153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055009154 S-adenosylmethionine binding site [chemical binding]; other site 585055009155 fragment of hybrid sensory histidine kinase, in two-component regulatory system with UvrY (part 1);Evidence 7 : Gene remnant; Product type r : regulator 585055009156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055009157 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055009158 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055009159 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055009160 fragment of hybrid sensory histidine kinase, in two-component regulatory system with UvrY (part 2);Evidence 7 : Gene remnant; Product type r : regulator 585055009161 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585055009162 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585055009163 active site 585055009164 tetramer interface [polypeptide binding]; other site 585055009165 fragment of glucarate dehydratase (part 2);Evidence 7 : Gene remnant; Product type e : enzyme 585055009166 fragment of glucarate dehydratase (part 1);Evidence 7 : Gene remnant; Product type e : enzyme 585055009167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009168 D-galactonate transporter; Region: 2A0114; TIGR00893 585055009169 putative substrate translocation pore; other site 585055009170 flavodoxin; Provisional; Region: PRK08105 585055009171 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585055009172 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 585055009173 probable active site [active] 585055009174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 585055009175 SecY interacting protein Syd; Provisional; Region: PRK04968 585055009176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 585055009177 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 585055009178 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 585055009179 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 585055009180 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 585055009181 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585055009182 serine transporter; Region: stp; TIGR00814 585055009183 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 585055009184 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585055009185 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585055009186 flap endonuclease-like protein; Provisional; Region: PRK09482 585055009187 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585055009188 active site 585055009189 metal binding site 1 [ion binding]; metal-binding site 585055009190 putative 5' ssDNA interaction site; other site 585055009191 metal binding site 3; metal-binding site 585055009192 metal binding site 2 [ion binding]; metal-binding site 585055009193 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585055009194 putative DNA binding site [nucleotide binding]; other site 585055009195 putative metal binding site [ion binding]; other site 585055009196 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 585055009197 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585055009198 dimer interface [polypeptide binding]; other site 585055009199 active site 585055009200 metal binding site [ion binding]; metal-binding site 585055009201 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585055009202 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585055009203 intersubunit interface [polypeptide binding]; other site 585055009204 active site 585055009205 Zn2+ binding site [ion binding]; other site 585055009206 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 585055009207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009208 putative substrate translocation pore; other site 585055009209 L-fucose isomerase; Provisional; Region: fucI; PRK10991 585055009210 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 585055009211 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585055009212 trimer interface [polypeptide binding]; other site 585055009213 substrate binding site [chemical binding]; other site 585055009214 Mn binding site [ion binding]; other site 585055009215 L-fuculokinase; Provisional; Region: PRK10331 585055009216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585055009217 nucleotide binding site [chemical binding]; other site 585055009218 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 585055009219 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 585055009220 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585055009221 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055009222 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 585055009223 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 585055009224 hypothetical protein; Provisional; Region: PRK10873 585055009225 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 585055009226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055009227 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 585055009228 dimerization interface [polypeptide binding]; other site 585055009229 substrate binding pocket [chemical binding]; other site 585055009230 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585055009231 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585055009232 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585055009233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585055009234 catalytic residue [active] 585055009235 CsdA-binding activator; Provisional; Region: PRK15019 585055009236 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 585055009237 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 585055009238 putative ATP binding site [chemical binding]; other site 585055009239 putative substrate interface [chemical binding]; other site 585055009240 murein transglycosylase A; Provisional; Region: mltA; PRK11162 585055009241 MltA specific insert domain; Region: MltA; pfam03562 585055009242 3D domain; Region: 3D; pfam06725 585055009243 AMIN domain; Region: AMIN; pfam11741 585055009244 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585055009245 active site 585055009246 metal binding site [ion binding]; metal-binding site 585055009247 N-acetylglutamate synthase; Validated; Region: PRK05279 585055009248 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 585055009249 putative feedback inhibition sensing region; other site 585055009250 putative nucleotide binding site [chemical binding]; other site 585055009251 putative substrate binding site [chemical binding]; other site 585055009252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055009253 Coenzyme A binding pocket [chemical binding]; other site 585055009254 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 585055009255 AAA domain; Region: AAA_30; pfam13604 585055009256 Family description; Region: UvrD_C_2; pfam13538 585055009257 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 585055009258 protease3; Provisional; Region: PRK15101 585055009259 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585055009260 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585055009261 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585055009262 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 585055009263 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 585055009264 hypothetical protein; Provisional; Region: PRK10332 585055009265 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 585055009266 hypothetical protein; Provisional; Region: PRK11521 585055009267 hypothetical protein; Provisional; Region: PRK10557 585055009268 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585055009269 hypothetical protein; Provisional; Region: PRK10506 585055009270 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585055009271 thymidylate synthase; Reviewed; Region: thyA; PRK01827 585055009272 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 585055009273 dimerization interface [polypeptide binding]; other site 585055009274 active site 585055009275 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 585055009276 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 585055009277 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585055009278 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585055009279 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585055009280 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585055009281 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 585055009282 putative active site [active] 585055009283 Ap4A binding site [chemical binding]; other site 585055009284 nudix motif; other site 585055009285 putative metal binding site [ion binding]; other site 585055009286 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 585055009287 putative DNA-binding cleft [nucleotide binding]; other site 585055009288 putative DNA clevage site; other site 585055009289 molecular lever; other site 585055009290 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585055009291 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585055009292 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055009293 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055009294 active site 585055009295 catalytic tetrad [active] 585055009296 lysophospholipid transporter LplT; Provisional; Region: PRK11195 585055009297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009298 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 585055009299 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585055009300 putative acyl-acceptor binding pocket; other site 585055009301 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 585055009302 acyl-activating enzyme (AAE) consensus motif; other site 585055009303 putative AMP binding site [chemical binding]; other site 585055009304 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 585055009305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055009306 DNA binding site [nucleotide binding] 585055009307 domain linker motif; other site 585055009308 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585055009309 dimerization interface (closed form) [polypeptide binding]; other site 585055009310 ligand binding site [chemical binding]; other site 585055009311 diaminopimelate decarboxylase; Provisional; Region: PRK11165 585055009312 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 585055009313 active site 585055009314 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585055009315 substrate binding site [chemical binding]; other site 585055009316 catalytic residues [active] 585055009317 dimer interface [polypeptide binding]; other site 585055009318 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 585055009319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055009320 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 585055009321 putative dimerization interface [polypeptide binding]; other site 585055009322 putative racemase; Provisional; Region: PRK10200 585055009323 aspartate racemase; Region: asp_race; TIGR00035 585055009324 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585055009325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009326 putative substrate translocation pore; other site 585055009327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009328 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 585055009329 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585055009330 NADP binding site [chemical binding]; other site 585055009331 homodimer interface [polypeptide binding]; other site 585055009332 active site 585055009333 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 585055009334 putative acyltransferase; Provisional; Region: PRK05790 585055009335 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585055009336 dimer interface [polypeptide binding]; other site 585055009337 active site 585055009338 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585055009339 serine transporter; Region: stp; TIGR00814 585055009340 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 585055009341 DNA binding residues [nucleotide binding] 585055009342 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585055009343 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 585055009344 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 585055009345 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 585055009346 Tetratricopeptide repeat; Region: TPR_3; pfam07720 585055009347 Tetratricopeptide repeat; Region: TPR_3; pfam07720 585055009348 transcriptional regulator; Provisional; Region: PRK11906 585055009349 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585055009350 DNA binding site [nucleotide binding] 585055009351 Tetratricopeptide repeat; Region: TPR_2; pfam07719 585055009352 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585055009353 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585055009354 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585055009355 catalytic residue [active] 585055009356 fragment of Bacterial regulatory protein LuxR family (part 2);Evidence 7 : Gene remnant 585055009357 fragment of Bacterial regulatory protein LuxR family (part 1);Evidence 7 : Gene remnant 585055009358 invasion protein OrgB; Provisional; Region: PRK15322 585055009359 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 585055009360 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 585055009361 fragment of type III secretion apparatus protein (partial);Evidence 7 : Gene remnant 585055009362 Type III secretion needle MxiH like; Region: MxiH; cl09641 585055009363 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 585055009364 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 585055009365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055009366 DNA binding residues [nucleotide binding] 585055009367 dimerization interface [polypeptide binding]; other site 585055009368 InvH outer membrane lipoprotein; Region: InvH; pfam04741 585055009369 fragment of Surface presentation of antigens protein (part 3);Evidence 7 : Gene remnant; Product type m : membrane component 585055009370 fragment of Surface presentation of antigens protein (part 2);Evidence 7 : Gene remnant; Product type m : membrane component 585055009371 fragment of Surface presentation of antigens protein (part 1);Evidence 7 : Gene remnant; Product type m : membrane component 585055009372 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 585055009373 fragment of surface presentation of antigens protein (partial);Evidence 7 : Gene remnant; Product type pm : membrane component 585055009374 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 585055009375 fragment of Type III secretion apparatus protein (part 2);Evidence 7 : Gene remnant; Product type t : transporter 585055009376 fragment of Type III secretion apparatus protein (part 1);Evidence 7 : Gene remnant; Product type t : transporter 585055009377 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 585055009378 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585055009379 Peptidase family M23; Region: Peptidase_M23; pfam01551 585055009380 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 585055009381 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585055009382 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585055009383 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 585055009384 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585055009385 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 585055009386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585055009387 catalytic loop [active] 585055009388 iron binding site [ion binding]; other site 585055009389 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585055009390 GAF domain; Region: GAF; cl17456 585055009391 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 585055009392 PAS domain; Region: PAS; smart00091 585055009393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055009394 Walker A motif; other site 585055009395 ATP binding site [chemical binding]; other site 585055009396 Walker B motif; other site 585055009397 arginine finger; other site 585055009398 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585055009399 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 585055009400 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585055009401 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585055009402 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585055009403 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 585055009404 catalytic residue [active] 585055009405 peptidase; Reviewed; Region: PRK13004 585055009406 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 585055009407 putative metal binding site [ion binding]; other site 585055009408 putative dimer interface [polypeptide binding]; other site 585055009409 D-hydantoinase; Region: D-hydantoinase; TIGR02033 585055009410 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 585055009411 tetramer interface [polypeptide binding]; other site 585055009412 active site 585055009413 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585055009414 carbamate kinase; Reviewed; Region: PRK12686 585055009415 putative substrate binding site [chemical binding]; other site 585055009416 homodimer interface [polypeptide binding]; other site 585055009417 nucleotide binding site [chemical binding]; other site 585055009418 nucleotide binding site [chemical binding]; other site 585055009419 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 585055009420 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 585055009421 XdhC Rossmann domain; Region: XdhC_C; pfam13478 585055009422 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 585055009423 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 585055009424 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 585055009425 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 585055009426 Ligand binding site; other site 585055009427 metal-binding site 585055009428 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 585055009429 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585055009430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055009431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055009432 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 585055009433 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 585055009434 active site 585055009435 putative substrate binding pocket [chemical binding]; other site 585055009436 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 585055009437 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585055009438 putative hypoxanthine oxidase; Provisional; Region: PRK09800 585055009439 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585055009440 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585055009441 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585055009442 uracil-xanthine permease; Region: ncs2; TIGR00801 585055009443 guanine deaminase; Provisional; Region: PRK09228 585055009444 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 585055009445 active site 585055009446 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585055009447 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585055009448 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 585055009449 4Fe-4S binding domain; Region: Fer4; pfam00037 585055009450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585055009451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055009452 xanthine permease; Region: pbuX; TIGR03173 585055009453 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 585055009454 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 585055009455 active site 585055009456 metal binding site [ion binding]; metal-binding site 585055009457 nudix motif; other site 585055009458 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 585055009459 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585055009460 dimer interface [polypeptide binding]; other site 585055009461 putative anticodon binding site; other site 585055009462 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585055009463 motif 1; other site 585055009464 active site 585055009465 motif 2; other site 585055009466 motif 3; other site 585055009467 peptide chain release factor 2; Validated; Region: prfB; PRK00578 585055009468 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585055009469 RF-1 domain; Region: RF-1; pfam00472 585055009470 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 585055009471 DHH family; Region: DHH; pfam01368 585055009472 DHHA1 domain; Region: DHHA1; pfam02272 585055009473 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 585055009474 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585055009475 dimerization domain [polypeptide binding]; other site 585055009476 dimer interface [polypeptide binding]; other site 585055009477 catalytic residues [active] 585055009478 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 585055009479 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 585055009480 active site 585055009481 Int/Topo IB signature motif; other site 585055009482 flavodoxin FldB; Provisional; Region: PRK12359 585055009483 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 585055009484 hypothetical protein; Provisional; Region: PRK10878 585055009485 putative global regulator; Reviewed; Region: PRK09559 585055009486 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 585055009487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055009488 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055009489 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055009490 hemolysin; Provisional; Region: PRK15087 585055009491 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 585055009492 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 585055009493 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 585055009494 beta-galactosidase; Region: BGL; TIGR03356 585055009495 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 585055009496 classical (c) SDRs; Region: SDR_c; cd05233 585055009497 NAD(P) binding site [chemical binding]; other site 585055009498 active site 585055009499 glycine dehydrogenase; Provisional; Region: PRK05367 585055009500 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585055009501 tetramer interface [polypeptide binding]; other site 585055009502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055009503 catalytic residue [active] 585055009504 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585055009505 tetramer interface [polypeptide binding]; other site 585055009506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055009507 catalytic residue [active] 585055009508 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 585055009509 lipoyl attachment site [posttranslational modification]; other site 585055009510 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 585055009511 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 585055009512 oxidoreductase; Provisional; Region: PRK08013 585055009513 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585055009514 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 585055009515 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585055009516 proline aminopeptidase P II; Provisional; Region: PRK10879 585055009517 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 585055009518 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585055009519 active site 585055009520 hypothetical protein; Reviewed; Region: PRK01736 585055009521 Z-ring-associated protein; Provisional; Region: PRK10972 585055009522 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 585055009523 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 585055009524 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 585055009525 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 585055009526 ligand binding site [chemical binding]; other site 585055009527 NAD binding site [chemical binding]; other site 585055009528 tetramer interface [polypeptide binding]; other site 585055009529 catalytic site [active] 585055009530 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 585055009531 L-serine binding site [chemical binding]; other site 585055009532 ACT domain interface; other site 585055009533 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 585055009534 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585055009535 active site 585055009536 dimer interface [polypeptide binding]; other site 585055009537 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 585055009538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055009539 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 585055009540 putative dimerization interface [polypeptide binding]; other site 585055009541 fragment of methylmalonyl-CoA mutase (part 1);Evidence 7 : Gene remnant; Product type e : enzyme 585055009542 fragment of methylmalonyl-CoA mutase (part 2);Evidence 7 : Gene remnant; Product type e : enzyme 585055009543 membrane ATPase/protein kinase; Provisional; Region: PRK09435 585055009544 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 585055009545 Walker A; other site 585055009546 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 585055009547 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585055009548 substrate binding site [chemical binding]; other site 585055009549 oxyanion hole (OAH) forming residues; other site 585055009550 trimer interface [polypeptide binding]; other site 585055009551 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 585055009552 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 585055009553 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 585055009554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055009555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055009556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055009557 dimerization interface [polypeptide binding]; other site 585055009558 Uncharacterized conserved protein [Function unknown]; Region: COG2968 585055009559 oxidative stress defense protein; Provisional; Region: PRK11087 585055009560 arginine exporter protein; Provisional; Region: PRK09304 585055009561 mechanosensitive channel MscS; Provisional; Region: PRK10334 585055009562 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585055009563 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585055009564 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 585055009565 active site 585055009566 intersubunit interface [polypeptide binding]; other site 585055009567 zinc binding site [ion binding]; other site 585055009568 Na+ binding site [ion binding]; other site 585055009569 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 585055009570 Phosphoglycerate kinase; Region: PGK; pfam00162 585055009571 substrate binding site [chemical binding]; other site 585055009572 hinge regions; other site 585055009573 ADP binding site [chemical binding]; other site 585055009574 catalytic site [active] 585055009575 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 585055009576 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585055009577 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585055009578 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 585055009579 trimer interface [polypeptide binding]; other site 585055009580 putative Zn binding site [ion binding]; other site 585055009581 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 585055009582 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 585055009583 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 585055009584 Walker A/P-loop; other site 585055009585 ATP binding site [chemical binding]; other site 585055009586 Q-loop/lid; other site 585055009587 ABC transporter signature motif; other site 585055009588 Walker B; other site 585055009589 D-loop; other site 585055009590 H-loop/switch region; other site 585055009591 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 585055009592 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 585055009593 Walker A/P-loop; other site 585055009594 ATP binding site [chemical binding]; other site 585055009595 Q-loop/lid; other site 585055009596 ABC transporter signature motif; other site 585055009597 Walker B; other site 585055009598 D-loop; other site 585055009599 H-loop/switch region; other site 585055009600 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 585055009601 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585055009602 active site 585055009603 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585055009604 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 585055009605 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585055009606 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585055009607 putative active site [active] 585055009608 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585055009609 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585055009610 putative NAD(P) binding site [chemical binding]; other site 585055009611 catalytic Zn binding site [ion binding]; other site 585055009612 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 585055009613 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585055009614 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585055009615 active site 585055009616 P-loop; other site 585055009617 phosphorylation site [posttranslational modification] 585055009618 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055009619 active site 585055009620 phosphorylation site [posttranslational modification] 585055009621 transketolase; Reviewed; Region: PRK12753 585055009622 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585055009623 TPP-binding site [chemical binding]; other site 585055009624 dimer interface [polypeptide binding]; other site 585055009625 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585055009626 PYR/PP interface [polypeptide binding]; other site 585055009627 dimer interface [polypeptide binding]; other site 585055009628 TPP binding site [chemical binding]; other site 585055009629 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585055009630 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585055009631 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 585055009632 agmatinase; Region: agmatinase; TIGR01230 585055009633 oligomer interface [polypeptide binding]; other site 585055009634 putative active site [active] 585055009635 Mn binding site [ion binding]; other site 585055009636 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 585055009637 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 585055009638 dimer interface [polypeptide binding]; other site 585055009639 active site 585055009640 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585055009641 catalytic residues [active] 585055009642 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 585055009643 Virulence promoting factor; Region: YqgB; pfam11036 585055009644 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 585055009645 S-adenosylmethionine synthetase; Validated; Region: PRK05250 585055009646 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 585055009647 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 585055009648 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 585055009649 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585055009650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009651 putative substrate translocation pore; other site 585055009652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055009653 hypothetical protein; Provisional; Region: PRK04860 585055009654 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 585055009655 DNA-specific endonuclease I; Provisional; Region: PRK15137 585055009656 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 585055009657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 585055009658 RNA methyltransferase, RsmE family; Region: TIGR00046 585055009659 glutathione synthetase; Provisional; Region: PRK05246 585055009660 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 585055009661 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 585055009662 hypothetical protein; Validated; Region: PRK00228 585055009663 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 585055009664 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 585055009665 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 585055009666 Walker A motif; other site 585055009667 ATP binding site [chemical binding]; other site 585055009668 Walker B motif; other site 585055009669 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 585055009670 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585055009671 catalytic residue [active] 585055009672 YGGT family; Region: YGGT; pfam02325 585055009673 YGGT family; Region: YGGT; pfam02325 585055009674 hypothetical protein; Validated; Region: PRK05090 585055009675 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 585055009676 active site 585055009677 dimerization interface [polypeptide binding]; other site 585055009678 HemN family oxidoreductase; Provisional; Region: PRK05660 585055009679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055009680 FeS/SAM binding site; other site 585055009681 HemN C-terminal domain; Region: HemN_C; pfam06969 585055009682 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 585055009683 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 585055009684 homodimer interface [polypeptide binding]; other site 585055009685 active site 585055009686 hypothetical protein; Provisional; Region: PRK10626 585055009687 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 585055009688 hypothetical protein; Provisional; Region: PRK11702 585055009689 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 585055009690 adenine DNA glycosylase; Provisional; Region: PRK10880 585055009691 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585055009692 minor groove reading motif; other site 585055009693 helix-hairpin-helix signature motif; other site 585055009694 substrate binding pocket [chemical binding]; other site 585055009695 active site 585055009696 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 585055009697 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 585055009698 DNA binding and oxoG recognition site [nucleotide binding] 585055009699 oxidative damage protection protein; Provisional; Region: PRK05408 585055009700 murein transglycosylase C; Provisional; Region: mltC; PRK11671 585055009701 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 585055009702 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585055009703 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585055009704 catalytic residue [active] 585055009705 nucleoside transporter; Region: 2A0110; TIGR00889 585055009706 ornithine decarboxylase; Provisional; Region: PRK13578 585055009707 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585055009708 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585055009709 homodimer interface [polypeptide binding]; other site 585055009710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055009711 catalytic residue [active] 585055009712 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585055009713 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 585055009714 integrase; Provisional; Region: PRK09692 585055009715 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585055009716 active site 585055009717 Int/Topo IB signature motif; other site 585055009718 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 585055009719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055009720 ATP binding site [chemical binding]; other site 585055009721 putative Mg++ binding site [ion binding]; other site 585055009722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055009723 nucleotide binding region [chemical binding]; other site 585055009724 ATP-binding site [chemical binding]; other site 585055009725 SNF-7-like protein; Provisional; Region: PTZ00464 585055009726 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 585055009727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055009728 Walker A motif; other site 585055009729 ATP binding site [chemical binding]; other site 585055009730 Walker B motif; other site 585055009731 arginine finger; other site 585055009732 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 585055009733 active site 585055009734 catalytic triad [active] 585055009735 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 585055009736 DNA methylase; Region: N6_N4_Mtase; pfam01555 585055009737 DNA methylase; Region: N6_N4_Mtase; pfam01555 585055009738 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 585055009739 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585055009740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585055009741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055009742 Transposase; Region: HTH_Tnp_1; pfam01527 585055009743 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 585055009744 Helix-turn-helix domain; Region: HTH_38; pfam13936 585055009745 Integrase core domain; Region: rve; pfam00665 585055009746 HTH-like domain; Region: HTH_21; pfam13276 585055009747 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055009748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055009749 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055009750 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585055009751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055009752 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585055009753 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585055009754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055009755 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585055009756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055009757 Transposase; Region: HTH_Tnp_1; pfam01527 585055009758 fragment of transposase (partial);Evidence 7 : Gene remnant 585055009759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 585055009760 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 585055009761 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585055009762 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055009763 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055009764 fragment of transposase ORF B, IS911 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055009765 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 585055009766 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585055009767 putative active site [active] 585055009768 putative NTP binding site [chemical binding]; other site 585055009769 putative nucleic acid binding site [nucleotide binding]; other site 585055009770 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 585055009771 HTH-like domain; Region: HTH_21; pfam13276 585055009772 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585055009773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055009774 Walker A motif; other site 585055009775 ATP binding site [chemical binding]; other site 585055009776 Walker B motif; other site 585055009777 arginine finger; other site 585055009778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055009779 Walker A motif; other site 585055009780 ATP binding site [chemical binding]; other site 585055009781 Walker B motif; other site 585055009782 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585055009783 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 585055009784 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 585055009785 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 585055009786 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585055009787 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 585055009788 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 585055009789 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585055009790 PAAR motif; Region: PAAR_motif; cl15808 585055009791 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585055009792 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585055009793 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585055009794 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 585055009795 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585055009796 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585055009797 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 585055009798 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 585055009799 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585055009800 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585055009801 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055009802 Homeodomain-like domain; Region: HTH_23; pfam13384 585055009803 DDE superfamily endonuclease; Region: DDE_3; pfam13358 585055009804 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 585055009805 Integrase core domain; Region: rve; pfam00665 585055009806 Integrase core domain; Region: rve_3; cl15866 585055009807 PerC transcriptional activator; Region: PerC; pfam06069 585055009808 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 585055009809 ParB-like nuclease domain; Region: ParBc; pfam02195 585055009810 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 585055009811 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585055009812 Active Sites [active] 585055009813 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 585055009814 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585055009815 ImpA domain protein; Region: DUF3702; pfam12486 585055009816 Nuclease-related domain; Region: NERD; pfam08378 585055009817 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 585055009818 Part of AAA domain; Region: AAA_19; pfam13245 585055009819 Family description; Region: UvrD_C_2; pfam13538 585055009820 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 585055009821 hypothetical protein; Provisional; Region: PRK10040 585055009822 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585055009823 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 585055009824 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 585055009825 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585055009826 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585055009827 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585055009828 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585055009829 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 585055009830 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 585055009831 PAAR motif; Region: PAAR_motif; pfam05488 585055009832 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 585055009833 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 585055009834 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 585055009835 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 585055009836 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585055009837 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585055009838 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585055009839 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 585055009840 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585055009841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055009842 Walker A motif; other site 585055009843 ATP binding site [chemical binding]; other site 585055009844 Walker B motif; other site 585055009845 arginine finger; other site 585055009846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055009847 Walker A motif; other site 585055009848 ATP binding site [chemical binding]; other site 585055009849 Walker B motif; other site 585055009850 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585055009851 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585055009852 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 585055009853 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585055009854 ligand binding site [chemical binding]; other site 585055009855 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 585055009856 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 585055009857 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585055009858 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 585055009859 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585055009860 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585055009861 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585055009862 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585055009863 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585055009864 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585055009865 Haemolysin expression modulating protein; Region: HHA; pfam05321 585055009866 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055009867 Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673 585055009868 Predicted GTPase [General function prediction only]; Region: COG3596 585055009869 YfjP GTPase; Region: YfjP; cd11383 585055009870 G1 box; other site 585055009871 GTP/Mg2+ binding site [chemical binding]; other site 585055009872 Switch I region; other site 585055009873 G2 box; other site 585055009874 Switch II region; other site 585055009875 G3 box; other site 585055009876 G4 box; other site 585055009877 G5 box; other site 585055009878 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585055009879 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585055009880 hypothetical protein; Provisional; Region: PRK09945 585055009881 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585055009882 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055009883 Autotransporter beta-domain; Region: Autotransporter; smart00869 585055009884 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585055009885 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585055009886 fragment of antirestriction protein (partial);Evidence 7 : Gene remnant 585055009887 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585055009888 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585055009889 MPN+ (JAMM) motif; other site 585055009890 Zinc-binding site [ion binding]; other site 585055009891 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585055009892 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585055009893 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585055009894 Herpes virus major capsid protein; Region: Herpes_MCP; pfam03122 585055009895 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585055009896 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585055009897 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 585055009898 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 585055009899 GspL-like protein; Provisional; Region: PRK09662 585055009900 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 585055009901 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585055009902 type II secretion system protein J; Region: gspJ; TIGR01711 585055009903 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 585055009904 type II secretion system protein I; Region: gspI; TIGR01707 585055009905 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 585055009906 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 585055009907 Type II transport protein GspH; Region: GspH; pfam12019 585055009908 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585055009909 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 585055009910 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 585055009911 type II secretion system protein F; Region: GspF; TIGR02120 585055009912 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585055009913 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585055009914 type II secretion system protein E; Region: type_II_gspE; TIGR02533 585055009915 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585055009916 Walker A motif; other site 585055009917 ATP binding site [chemical binding]; other site 585055009918 Walker B motif; other site 585055009919 type II secretion system protein D; Region: type_II_gspD; TIGR02517 585055009920 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585055009921 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585055009922 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585055009923 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585055009924 putative type II secretion protein GspC; Provisional; Region: PRK09681 585055009925 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 585055009926 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585055009927 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585055009928 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 585055009929 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585055009930 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 585055009931 Peptidase M60-like family; Region: M60-like; pfam13402 585055009932 glycolate transporter; Provisional; Region: PRK09695 585055009933 L-lactate permease; Region: Lactate_perm; cl00701 585055009934 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 585055009935 active site 585055009936 hypothetical protein; Provisional; Region: PRK09732 585055009937 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 585055009938 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585055009939 Cysteine-rich domain; Region: CCG; pfam02754 585055009940 Cysteine-rich domain; Region: CCG; pfam02754 585055009941 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 585055009942 FAD binding domain; Region: FAD_binding_4; pfam01565 585055009943 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 585055009944 FAD binding domain; Region: FAD_binding_4; pfam01565 585055009945 fragment of DNA-binding transcriptional dual regulator, glycolate-binding (partial);Evidence 7 : Gene remnant; Product type r : regulator 585055009946 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055009947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055009948 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055009949 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055009950 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055009951 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585055009952 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585055009953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585055009954 catalytic residue [active] 585055009955 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 585055009956 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585055009957 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585055009958 Predicted permeases [General function prediction only]; Region: COG0795 585055009959 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 585055009960 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585055009961 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585055009962 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585055009963 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585055009964 active site 585055009965 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585055009966 TMP-binding site; other site 585055009967 ATP-binding site [chemical binding]; other site 585055009968 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585055009969 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585055009970 TMP-binding site; other site 585055009971 ATP-binding site [chemical binding]; other site 585055009972 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585055009973 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585055009974 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 585055009975 CHAP domain; Region: CHAP; pfam05257 585055009976 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585055009977 putative S-transferase; Provisional; Region: PRK11752 585055009978 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585055009979 C-terminal domain interface [polypeptide binding]; other site 585055009980 GSH binding site (G-site) [chemical binding]; other site 585055009981 dimer interface [polypeptide binding]; other site 585055009982 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 585055009983 dimer interface [polypeptide binding]; other site 585055009984 N-terminal domain interface [polypeptide binding]; other site 585055009985 active site 585055009986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055009987 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055009988 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055009989 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 585055009990 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 585055009991 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 585055009992 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 585055009993 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 585055009994 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585055009995 putative substrate-binding site; other site 585055009996 nickel binding site [ion binding]; other site 585055009997 hydrogenase 2 large subunit; Provisional; Region: PRK10467 585055009998 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585055009999 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 585055010000 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 585055010001 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 585055010002 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585055010003 hydrogenase 2 small subunit; Provisional; Region: PRK10468 585055010004 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585055010005 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585055010006 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 585055010007 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585055010008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585055010009 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055010010 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055010011 active site 585055010012 catalytic tetrad [active] 585055010013 hypothetical protein; Provisional; Region: PRK05208 585055010014 oxidoreductase; Provisional; Region: PRK07985 585055010015 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 585055010016 NAD binding site [chemical binding]; other site 585055010017 metal binding site [ion binding]; metal-binding site 585055010018 active site 585055010019 biopolymer transport protein ExbD; Provisional; Region: PRK11267 585055010020 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585055010021 biopolymer transport protein ExbB; Provisional; Region: PRK10414 585055010022 cystathionine beta-lyase; Provisional; Region: PRK08114 585055010023 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585055010024 homodimer interface [polypeptide binding]; other site 585055010025 substrate-cofactor binding pocket; other site 585055010026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055010027 catalytic residue [active] 585055010028 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585055010029 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585055010030 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 585055010031 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585055010032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055010033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055010034 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 585055010035 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 585055010036 dimer interface [polypeptide binding]; other site 585055010037 active site 585055010038 metal binding site [ion binding]; metal-binding site 585055010039 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585055010040 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585055010041 active site 585055010042 catalytic tetrad [active] 585055010043 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 585055010044 putative outer membrane lipoprotein; Provisional; Region: PRK09973 585055010045 hypothetical protein; Provisional; Region: PRK01254 585055010046 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 585055010047 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 585055010048 FtsI repressor; Provisional; Region: PRK10883 585055010049 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585055010050 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585055010051 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 585055010052 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585055010053 putative acyl-acceptor binding pocket; other site 585055010054 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 585055010055 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585055010056 CAP-like domain; other site 585055010057 active site 585055010058 primary dimer interface [polypeptide binding]; other site 585055010059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585055010060 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 585055010061 TIGR00156 family protein; Region: TIGR00156 585055010062 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 585055010063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055010064 active site 585055010065 phosphorylation site [posttranslational modification] 585055010066 intermolecular recognition site; other site 585055010067 dimerization interface [polypeptide binding]; other site 585055010068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055010069 DNA binding site [nucleotide binding] 585055010070 sensor protein QseC; Provisional; Region: PRK10337 585055010071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055010072 dimer interface [polypeptide binding]; other site 585055010073 phosphorylation site [posttranslational modification] 585055010074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055010075 ATP binding site [chemical binding]; other site 585055010076 Mg2+ binding site [ion binding]; other site 585055010077 G-X-G motif; other site 585055010078 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 585055010079 Uncharacterized conserved protein [Function unknown]; Region: COG1359 585055010080 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 585055010081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055010082 ATP binding site [chemical binding]; other site 585055010083 Mg2+ binding site [ion binding]; other site 585055010084 G-X-G motif; other site 585055010085 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585055010086 anchoring element; other site 585055010087 dimer interface [polypeptide binding]; other site 585055010088 ATP binding site [chemical binding]; other site 585055010089 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 585055010090 active site 585055010091 metal binding site [ion binding]; metal-binding site 585055010092 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585055010093 esterase YqiA; Provisional; Region: PRK11071 585055010094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 585055010095 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 585055010096 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585055010097 active site 585055010098 metal binding site [ion binding]; metal-binding site 585055010099 hexamer interface [polypeptide binding]; other site 585055010100 putative dehydrogenase; Provisional; Region: PRK11039 585055010101 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 585055010102 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585055010103 dimer interface [polypeptide binding]; other site 585055010104 ADP-ribose binding site [chemical binding]; other site 585055010105 active site 585055010106 nudix motif; other site 585055010107 metal binding site [ion binding]; metal-binding site 585055010108 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 585055010109 hypothetical protein; Provisional; Region: PRK11653 585055010110 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585055010111 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 585055010112 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585055010113 putative active site [active] 585055010114 metal binding site [ion binding]; metal-binding site 585055010115 zinc transporter ZupT; Provisional; Region: PRK04201 585055010116 ZIP Zinc transporter; Region: Zip; pfam02535 585055010117 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 585055010118 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 585055010119 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 585055010120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 585055010121 putative fimbrial protein; Provisional; Region: PRK09733 585055010122 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585055010123 PapC N-terminal domain; Region: PapC_N; pfam13954 585055010124 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055010125 PapC C-terminal domain; Region: PapC_C; pfam13953 585055010126 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585055010127 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055010128 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055010129 Fimbrial protein; Region: Fimbrial; pfam00419 585055010130 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 585055010131 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 585055010132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 585055010133 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 585055010134 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 585055010135 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 585055010136 putative ribose interaction site [chemical binding]; other site 585055010137 putative ADP binding site [chemical binding]; other site 585055010138 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 585055010139 active site 585055010140 nucleotide binding site [chemical binding]; other site 585055010141 HIGH motif; other site 585055010142 KMSKS motif; other site 585055010143 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 585055010144 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585055010145 metal binding triad; other site 585055010146 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585055010147 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585055010148 metal binding triad; other site 585055010149 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585055010150 Uncharacterized conserved protein [Function unknown]; Region: COG3025 585055010151 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 585055010152 putative active site [active] 585055010153 putative metal binding residues [ion binding]; other site 585055010154 signature motif; other site 585055010155 putative triphosphate binding site [ion binding]; other site 585055010156 CHAD domain; Region: CHAD; pfam05235 585055010157 SH3 domain-containing protein; Provisional; Region: PRK10884 585055010158 Bacterial SH3 domain homologues; Region: SH3b; smart00287 585055010159 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 585055010160 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585055010161 active site 585055010162 NTP binding site [chemical binding]; other site 585055010163 metal binding triad [ion binding]; metal-binding site 585055010164 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585055010165 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585055010166 Zn2+ binding site [ion binding]; other site 585055010167 Mg2+ binding site [ion binding]; other site 585055010168 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 585055010169 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585055010170 homooctamer interface [polypeptide binding]; other site 585055010171 active site 585055010172 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 585055010173 transcriptional activator TtdR; Provisional; Region: PRK09801 585055010174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055010175 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 585055010176 putative effector binding pocket; other site 585055010177 putative dimerization interface [polypeptide binding]; other site 585055010178 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 585055010179 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 585055010180 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585055010181 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585055010182 transmembrane helices; other site 585055010183 UGMP family protein; Validated; Region: PRK09604 585055010184 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 585055010185 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 585055010186 DNA primase; Validated; Region: dnaG; PRK05667 585055010187 CHC2 zinc finger; Region: zf-CHC2; pfam01807 585055010188 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 585055010189 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 585055010190 active site 585055010191 metal binding site [ion binding]; metal-binding site 585055010192 interdomain interaction site; other site 585055010193 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 585055010194 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 585055010195 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 585055010196 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 585055010197 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585055010198 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 585055010199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585055010200 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585055010201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585055010202 DNA binding residues [nucleotide binding] 585055010203 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 585055010204 active site 585055010205 SUMO-1 interface [polypeptide binding]; other site 585055010206 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 585055010207 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 585055010208 FAD binding pocket [chemical binding]; other site 585055010209 FAD binding motif [chemical binding]; other site 585055010210 phosphate binding motif [ion binding]; other site 585055010211 NAD binding pocket [chemical binding]; other site 585055010212 Predicted transcriptional regulators [Transcription]; Region: COG1695 585055010213 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 585055010214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055010215 PAS fold; Region: PAS_3; pfam08447 585055010216 putative active site [active] 585055010217 heme pocket [chemical binding]; other site 585055010218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585055010219 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 585055010220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585055010221 dimer interface [polypeptide binding]; other site 585055010222 putative CheW interface [polypeptide binding]; other site 585055010223 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 585055010224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585055010225 inhibitor-cofactor binding pocket; inhibition site 585055010226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055010227 catalytic residue [active] 585055010228 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 585055010229 dimer interface [polypeptide binding]; other site 585055010230 putative tRNA-binding site [nucleotide binding]; other site 585055010231 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 585055010232 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055010233 DNA binding site [nucleotide binding] 585055010234 domain linker motif; other site 585055010235 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 585055010236 putative dimerization interface [polypeptide binding]; other site 585055010237 putative ligand binding site [chemical binding]; other site 585055010238 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 585055010239 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585055010240 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585055010241 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585055010242 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585055010243 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 585055010244 inner membrane transporter YjeM; Provisional; Region: PRK15238 585055010245 alpha-glucosidase; Provisional; Region: PRK10137 585055010246 Protein of unknown function, DUF608; Region: DUF608; pfam04685 585055010247 Trehalase; Region: Trehalase; cl17346 585055010248 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585055010249 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 585055010250 active site 585055010251 FMN binding site [chemical binding]; other site 585055010252 2,4-decadienoyl-CoA binding site; other site 585055010253 catalytic residue [active] 585055010254 4Fe-4S cluster binding site [ion binding]; other site 585055010255 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 585055010256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055010257 non-specific DNA binding site [nucleotide binding]; other site 585055010258 salt bridge; other site 585055010259 sequence-specific DNA binding site [nucleotide binding]; other site 585055010260 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 585055010261 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 585055010262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055010263 S-adenosylmethionine binding site [chemical binding]; other site 585055010264 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 585055010265 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585055010266 putative active site [active] 585055010267 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585055010268 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585055010269 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 585055010270 serine/threonine transporter SstT; Provisional; Region: PRK13628 585055010271 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585055010272 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 585055010273 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585055010274 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585055010275 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585055010276 Glucuronate isomerase; Region: UxaC; pfam02614 585055010277 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 585055010278 D-galactonate transporter; Region: 2A0114; TIGR00893 585055010279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055010280 putative substrate translocation pore; other site 585055010281 CblD like pilus biogenesis initiator; Region: CblD; cl06460 585055010282 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 585055010283 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055010284 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 585055010285 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585055010286 putative fimbrial protein TcfA; Provisional; Region: PRK15308 585055010287 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 585055010288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055010289 DNA-binding site [nucleotide binding]; DNA binding site 585055010290 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585055010291 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585055010292 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585055010293 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 585055010294 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 585055010295 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 585055010296 Predicted membrane protein [Function unknown]; Region: COG5393 585055010297 YqjK-like protein; Region: YqjK; pfam13997 585055010298 Predicted membrane protein [Function unknown]; Region: COG2259 585055010299 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 585055010300 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 585055010301 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 585055010302 putative dimer interface [polypeptide binding]; other site 585055010303 N-terminal domain interface [polypeptide binding]; other site 585055010304 putative substrate binding pocket (H-site) [chemical binding]; other site 585055010305 Predicted membrane protein [Function unknown]; Region: COG3152 585055010306 Protein of unknown function (DUF805); Region: DUF805; pfam05656 585055010307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055010308 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585055010309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055010310 dimerization interface [polypeptide binding]; other site 585055010311 Pirin-related protein [General function prediction only]; Region: COG1741 585055010312 Pirin; Region: Pirin; pfam02678 585055010313 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 585055010314 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585055010315 serine transporter; Region: stp; TIGR00814 585055010316 L-serine dehydratase TdcG; Provisional; Region: PRK15040 585055010317 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585055010318 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585055010319 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585055010320 homotrimer interaction site [polypeptide binding]; other site 585055010321 putative active site [active] 585055010322 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585055010323 Pyruvate formate lyase 1; Region: PFL1; cd01678 585055010324 coenzyme A binding site [chemical binding]; other site 585055010325 active site 585055010326 catalytic residues [active] 585055010327 glycine loop; other site 585055010328 propionate/acetate kinase; Provisional; Region: PRK12379 585055010329 Acetokinase family; Region: Acetate_kinase; cl17229 585055010330 threonine/serine transporter TdcC; Provisional; Region: PRK13629 585055010331 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585055010332 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585055010333 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585055010334 tetramer interface [polypeptide binding]; other site 585055010335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055010336 catalytic residue [active] 585055010337 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 585055010338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055010339 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 585055010340 putative substrate binding pocket [chemical binding]; other site 585055010341 putative dimerization interface [polypeptide binding]; other site 585055010342 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 585055010343 hypothetical protein; Provisional; Region: PRK09716 585055010344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055010345 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055010346 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055010347 glycerate kinase I; Provisional; Region: PRK10342 585055010348 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 585055010349 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585055010350 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 585055010351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055010352 D-galactonate transporter; Region: 2A0114; TIGR00893 585055010353 putative substrate translocation pore; other site 585055010354 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585055010355 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585055010356 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585055010357 putative regulator PrlF; Provisional; Region: PRK09974 585055010358 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 585055010359 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 585055010360 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 585055010361 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585055010362 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055010363 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 585055010364 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585055010365 active site 585055010366 phosphorylation site [posttranslational modification] 585055010367 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 585055010368 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 585055010369 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585055010370 active pocket/dimerization site; other site 585055010371 active site 585055010372 phosphorylation site [posttranslational modification] 585055010373 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 585055010374 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585055010375 active site 585055010376 dimer interface [polypeptide binding]; other site 585055010377 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 585055010378 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585055010379 dimer interface [polypeptide binding]; other site 585055010380 active site 585055010381 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 585055010382 putative active site [active] 585055010383 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 585055010384 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585055010385 active site 585055010386 intersubunit interface [polypeptide binding]; other site 585055010387 zinc binding site [ion binding]; other site 585055010388 Na+ binding site [ion binding]; other site 585055010389 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585055010390 active site 585055010391 phosphorylation site [posttranslational modification] 585055010392 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 585055010393 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 585055010394 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585055010395 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585055010396 active site 585055010397 trimer interface [polypeptide binding]; other site 585055010398 allosteric site; other site 585055010399 active site lid [active] 585055010400 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585055010401 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585055010402 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055010403 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055010404 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585055010405 PapC N-terminal domain; Region: PapC_N; pfam13954 585055010406 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055010407 PapC C-terminal domain; Region: PapC_C; pfam13953 585055010408 Fimbrial protein; Region: Fimbrial; pfam00419 585055010409 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 585055010410 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 585055010411 putative SAM binding site [chemical binding]; other site 585055010412 putative homodimer interface [polypeptide binding]; other site 585055010413 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585055010414 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 585055010415 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 585055010416 putative ligand binding site [chemical binding]; other site 585055010417 TIGR00252 family protein; Region: TIGR00252 585055010418 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585055010419 dimer interface [polypeptide binding]; other site 585055010420 active site 585055010421 outer membrane lipoprotein; Provisional; Region: PRK11023 585055010422 BON domain; Region: BON; pfam04972 585055010423 BON domain; Region: BON; pfam04972 585055010424 Predicted permease; Region: DUF318; pfam03773 585055010425 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 585055010426 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585055010427 NAD binding site [chemical binding]; other site 585055010428 active site 585055010429 intracellular protease, PfpI family; Region: PfpI; TIGR01382 585055010430 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 585055010431 proposed catalytic triad [active] 585055010432 conserved cys residue [active] 585055010433 hypothetical protein; Provisional; Region: PRK03467 585055010434 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 585055010435 GIY-YIG motif/motif A; other site 585055010436 putative active site [active] 585055010437 putative metal binding site [ion binding]; other site 585055010438 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585055010439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055010440 Coenzyme A binding pocket [chemical binding]; other site 585055010441 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 585055010442 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585055010443 Peptidase family U32; Region: Peptidase_U32; pfam01136 585055010444 putative protease; Provisional; Region: PRK15447 585055010445 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585055010446 hypothetical protein; Provisional; Region: PRK10508 585055010447 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 585055010448 tryptophan permease; Provisional; Region: PRK10483 585055010449 aromatic amino acid transport protein; Region: araaP; TIGR00837 585055010450 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 585055010451 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585055010452 ATP binding site [chemical binding]; other site 585055010453 Mg++ binding site [ion binding]; other site 585055010454 motif III; other site 585055010455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055010456 nucleotide binding region [chemical binding]; other site 585055010457 ATP-binding site [chemical binding]; other site 585055010458 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 585055010459 putative RNA binding site [nucleotide binding]; other site 585055010460 lipoprotein NlpI; Provisional; Region: PRK11189 585055010461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055010462 binding surface 585055010463 TPR motif; other site 585055010464 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 585055010465 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 585055010466 RNase E interface [polypeptide binding]; other site 585055010467 trimer interface [polypeptide binding]; other site 585055010468 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 585055010469 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 585055010470 RNase E interface [polypeptide binding]; other site 585055010471 trimer interface [polypeptide binding]; other site 585055010472 active site 585055010473 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 585055010474 putative nucleic acid binding region [nucleotide binding]; other site 585055010475 G-X-X-G motif; other site 585055010476 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 585055010477 RNA binding site [nucleotide binding]; other site 585055010478 domain interface; other site 585055010479 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 585055010480 16S/18S rRNA binding site [nucleotide binding]; other site 585055010481 S13e-L30e interaction site [polypeptide binding]; other site 585055010482 25S rRNA binding site [nucleotide binding]; other site 585055010483 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 585055010484 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 585055010485 RNA binding site [nucleotide binding]; other site 585055010486 active site 585055010487 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 585055010488 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 585055010489 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585055010490 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 585055010491 translation initiation factor IF-2; Region: IF-2; TIGR00487 585055010492 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585055010493 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 585055010494 G1 box; other site 585055010495 putative GEF interaction site [polypeptide binding]; other site 585055010496 GTP/Mg2+ binding site [chemical binding]; other site 585055010497 Switch I region; other site 585055010498 G2 box; other site 585055010499 G3 box; other site 585055010500 Switch II region; other site 585055010501 G4 box; other site 585055010502 G5 box; other site 585055010503 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 585055010504 Translation-initiation factor 2; Region: IF-2; pfam11987 585055010505 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 585055010506 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 585055010507 NusA N-terminal domain; Region: NusA_N; pfam08529 585055010508 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 585055010509 RNA binding site [nucleotide binding]; other site 585055010510 homodimer interface [polypeptide binding]; other site 585055010511 NusA-like KH domain; Region: KH_5; pfam13184 585055010512 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 585055010513 G-X-X-G motif; other site 585055010514 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585055010515 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585055010516 ribosome maturation protein RimP; Reviewed; Region: PRK00092 585055010517 Sm and related proteins; Region: Sm_like; cl00259 585055010518 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 585055010519 putative oligomer interface [polypeptide binding]; other site 585055010520 putative RNA binding site [nucleotide binding]; other site 585055010521 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 585055010522 ANP binding site [chemical binding]; other site 585055010523 Substrate Binding Site II [chemical binding]; other site 585055010524 Substrate Binding Site I [chemical binding]; other site 585055010525 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585055010526 Sulfatase; Region: Sulfatase; pfam00884 585055010527 Preprotein translocase SecG subunit; Region: SecG; pfam03840 585055010528 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 585055010529 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 585055010530 active site 585055010531 substrate binding site [chemical binding]; other site 585055010532 metal binding site [ion binding]; metal-binding site 585055010533 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 585055010534 dihydropteroate synthase; Region: DHPS; TIGR01496 585055010535 substrate binding pocket [chemical binding]; other site 585055010536 dimer interface [polypeptide binding]; other site 585055010537 inhibitor binding site; inhibition site 585055010538 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 585055010539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055010540 Walker A motif; other site 585055010541 ATP binding site [chemical binding]; other site 585055010542 Walker B motif; other site 585055010543 arginine finger; other site 585055010544 Peptidase family M41; Region: Peptidase_M41; pfam01434 585055010545 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 585055010546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055010547 S-adenosylmethionine binding site [chemical binding]; other site 585055010548 RNA-binding protein YhbY; Provisional; Region: PRK10343 585055010549 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 585055010550 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585055010551 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585055010552 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 585055010553 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 585055010554 GTPase CgtA; Reviewed; Region: obgE; PRK12298 585055010555 GTP1/OBG; Region: GTP1_OBG; pfam01018 585055010556 Obg GTPase; Region: Obg; cd01898 585055010557 G1 box; other site 585055010558 GTP/Mg2+ binding site [chemical binding]; other site 585055010559 Switch I region; other site 585055010560 G2 box; other site 585055010561 G3 box; other site 585055010562 Switch II region; other site 585055010563 G4 box; other site 585055010564 G5 box; other site 585055010565 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585055010566 EamA-like transporter family; Region: EamA; pfam00892 585055010567 EamA-like transporter family; Region: EamA; pfam00892 585055010568 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 585055010569 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 585055010570 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 585055010571 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585055010572 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585055010573 substrate binding pocket [chemical binding]; other site 585055010574 chain length determination region; other site 585055010575 substrate-Mg2+ binding site; other site 585055010576 catalytic residues [active] 585055010577 aspartate-rich region 1; other site 585055010578 active site lid residues [active] 585055010579 aspartate-rich region 2; other site 585055010580 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 585055010581 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 585055010582 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 585055010583 hinge; other site 585055010584 active site 585055010585 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 585055010586 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 585055010587 anti sigma factor interaction site; other site 585055010588 regulatory phosphorylation site [posttranslational modification]; other site 585055010589 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 585055010590 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 585055010591 mce related protein; Region: MCE; pfam02470 585055010592 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 585055010593 conserved hypothetical integral membrane protein; Region: TIGR00056 585055010594 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 585055010595 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 585055010596 Walker A/P-loop; other site 585055010597 ATP binding site [chemical binding]; other site 585055010598 Q-loop/lid; other site 585055010599 ABC transporter signature motif; other site 585055010600 Walker B; other site 585055010601 D-loop; other site 585055010602 H-loop/switch region; other site 585055010603 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 585055010604 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585055010605 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585055010606 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 585055010607 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585055010608 putative active site [active] 585055010609 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585055010610 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 585055010611 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 585055010612 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 585055010613 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 585055010614 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 585055010615 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 585055010616 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 585055010617 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 585055010618 Walker A/P-loop; other site 585055010619 ATP binding site [chemical binding]; other site 585055010620 Q-loop/lid; other site 585055010621 ABC transporter signature motif; other site 585055010622 Walker B; other site 585055010623 D-loop; other site 585055010624 H-loop/switch region; other site 585055010625 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 585055010626 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 585055010627 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 585055010628 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 585055010629 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585055010630 30S subunit binding site; other site 585055010631 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055010632 active site 585055010633 phosphorylation site [posttranslational modification] 585055010634 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 585055010635 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585055010636 dimerization domain swap beta strand [polypeptide binding]; other site 585055010637 regulatory protein interface [polypeptide binding]; other site 585055010638 active site 585055010639 regulatory phosphorylation site [posttranslational modification]; other site 585055010640 hypothetical protein; Provisional; Region: PRK10345 585055010641 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 585055010642 Transglycosylase; Region: Transgly; cl17702 585055010643 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 585055010644 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 585055010645 conserved cys residue [active] 585055010646 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 585055010647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055010648 putative active site [active] 585055010649 heme pocket [chemical binding]; other site 585055010650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055010651 dimer interface [polypeptide binding]; other site 585055010652 phosphorylation site [posttranslational modification] 585055010653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055010654 ATP binding site [chemical binding]; other site 585055010655 Mg2+ binding site [ion binding]; other site 585055010656 G-X-G motif; other site 585055010657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055010658 active site 585055010659 phosphorylation site [posttranslational modification] 585055010660 intermolecular recognition site; other site 585055010661 dimerization interface [polypeptide binding]; other site 585055010662 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585055010663 putative binding surface; other site 585055010664 active site 585055010665 radical SAM protein, TIGR01212 family; Region: TIGR01212 585055010666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055010667 FeS/SAM binding site; other site 585055010668 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 585055010669 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 585055010670 active site 585055010671 dimer interface [polypeptide binding]; other site 585055010672 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 585055010673 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 585055010674 active site 585055010675 FMN binding site [chemical binding]; other site 585055010676 substrate binding site [chemical binding]; other site 585055010677 3Fe-4S cluster binding site [ion binding]; other site 585055010678 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 585055010679 domain interface; other site 585055010680 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 585055010681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055010682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055010683 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055010684 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 585055010685 N-acetylmannosamine kinase; Provisional; Region: PRK05082 585055010686 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585055010687 nucleotide binding site [chemical binding]; other site 585055010688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585055010689 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 585055010690 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 585055010691 putative active site cavity [active] 585055010692 putative sialic acid transporter; Provisional; Region: PRK03893 585055010693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055010694 putative substrate translocation pore; other site 585055010695 N-acetylneuraminate lyase; Region: nanA; TIGR00683 585055010696 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 585055010697 inhibitor site; inhibition site 585055010698 active site 585055010699 dimer interface [polypeptide binding]; other site 585055010700 catalytic residue [active] 585055010701 transcriptional regulator NanR; Provisional; Region: PRK03837 585055010702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055010703 DNA-binding site [nucleotide binding]; DNA binding site 585055010704 FCD domain; Region: FCD; pfam07729 585055010705 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 585055010706 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585055010707 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 585055010708 stringent starvation protein A; Provisional; Region: sspA; PRK09481 585055010709 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 585055010710 C-terminal domain interface [polypeptide binding]; other site 585055010711 putative GSH binding site (G-site) [chemical binding]; other site 585055010712 dimer interface [polypeptide binding]; other site 585055010713 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 585055010714 dimer interface [polypeptide binding]; other site 585055010715 N-terminal domain interface [polypeptide binding]; other site 585055010716 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 585055010717 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 585055010718 23S rRNA interface [nucleotide binding]; other site 585055010719 L3 interface [polypeptide binding]; other site 585055010720 Predicted ATPase [General function prediction only]; Region: COG1485 585055010721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 585055010722 hypothetical protein; Provisional; Region: PRK11677 585055010723 serine endoprotease; Provisional; Region: PRK10139 585055010724 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585055010725 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585055010726 protein binding site [polypeptide binding]; other site 585055010727 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585055010728 serine endoprotease; Provisional; Region: PRK10898 585055010729 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585055010730 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585055010731 malate dehydrogenase; Provisional; Region: PRK05086 585055010732 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 585055010733 NAD binding site [chemical binding]; other site 585055010734 dimerization interface [polypeptide binding]; other site 585055010735 Substrate binding site [chemical binding]; other site 585055010736 arginine repressor; Provisional; Region: PRK05066 585055010737 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 585055010738 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 585055010739 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055010740 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 585055010741 RNAase interaction site [polypeptide binding]; other site 585055010742 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 585055010743 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585055010744 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 585055010745 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055010746 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055010747 efflux system membrane protein; Provisional; Region: PRK11594 585055010748 transcriptional regulator; Provisional; Region: PRK10632 585055010749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055010750 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 585055010751 putative effector binding pocket; other site 585055010752 dimerization interface [polypeptide binding]; other site 585055010753 protease TldD; Provisional; Region: tldD; PRK10735 585055010754 hypothetical protein; Provisional; Region: PRK10899 585055010755 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585055010756 ribonuclease G; Provisional; Region: PRK11712 585055010757 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585055010758 homodimer interface [polypeptide binding]; other site 585055010759 oligonucleotide binding site [chemical binding]; other site 585055010760 Maf-like protein; Region: Maf; pfam02545 585055010761 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585055010762 active site 585055010763 dimer interface [polypeptide binding]; other site 585055010764 rod shape-determining protein MreD; Provisional; Region: PRK11060 585055010765 rod shape-determining protein MreC; Region: mreC; TIGR00219 585055010766 rod shape-determining protein MreC; Region: MreC; pfam04085 585055010767 rod shape-determining protein MreB; Provisional; Region: PRK13927 585055010768 MreB and similar proteins; Region: MreB_like; cd10225 585055010769 nucleotide binding site [chemical binding]; other site 585055010770 Mg binding site [ion binding]; other site 585055010771 putative protofilament interaction site [polypeptide binding]; other site 585055010772 RodZ interaction site [polypeptide binding]; other site 585055010773 regulatory protein CsrD; Provisional; Region: PRK11059 585055010774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055010775 metal binding site [ion binding]; metal-binding site 585055010776 active site 585055010777 I-site; other site 585055010778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055010779 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 585055010780 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 585055010781 NADP binding site [chemical binding]; other site 585055010782 dimer interface [polypeptide binding]; other site 585055010783 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 585055010784 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 585055010785 carboxyltransferase (CT) interaction site; other site 585055010786 biotinylation site [posttranslational modification]; other site 585055010787 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 585055010788 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585055010789 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585055010790 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 585055010791 hypothetical protein; Provisional; Region: PRK10633 585055010792 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 585055010793 Na binding site [ion binding]; other site 585055010794 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 585055010795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585055010796 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 585055010797 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585055010798 FMN binding site [chemical binding]; other site 585055010799 active site 585055010800 catalytic residues [active] 585055010801 substrate binding site [chemical binding]; other site 585055010802 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 585055010803 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 585055010804 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585055010805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055010806 DNA methylase; Region: N6_N4_Mtase; pfam01555 585055010807 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 585055010808 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 585055010809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055010810 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585055010811 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585055010812 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055010813 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055010814 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 585055010815 Protein export membrane protein; Region: SecD_SecF; cl14618 585055010816 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 585055010817 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 585055010818 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055010819 substrate binding pocket [chemical binding]; other site 585055010820 membrane-bound complex binding site; other site 585055010821 hinge residues; other site 585055010822 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 585055010823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055010824 conserved gate region; other site 585055010825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055010826 dimer interface [polypeptide binding]; other site 585055010827 conserved gate region; other site 585055010828 putative PBP binding loops; other site 585055010829 ABC-ATPase subunit interface; other site 585055010830 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585055010831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055010832 dimer interface [polypeptide binding]; other site 585055010833 conserved gate region; other site 585055010834 putative PBP binding loops; other site 585055010835 ABC-ATPase subunit interface; other site 585055010836 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585055010837 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585055010838 Walker A/P-loop; other site 585055010839 ATP binding site [chemical binding]; other site 585055010840 Q-loop/lid; other site 585055010841 ABC transporter signature motif; other site 585055010842 Walker B; other site 585055010843 D-loop; other site 585055010844 H-loop/switch region; other site 585055010845 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 585055010846 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 585055010847 trimer interface [polypeptide binding]; other site 585055010848 putative metal binding site [ion binding]; other site 585055010849 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 585055010850 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 585055010851 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585055010852 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585055010853 shikimate binding site; other site 585055010854 NAD(P) binding site [chemical binding]; other site 585055010855 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 585055010856 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585055010857 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 585055010858 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585055010859 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585055010860 hypothetical protein; Validated; Region: PRK03430 585055010861 hypothetical protein; Provisional; Region: PRK10736 585055010862 DNA protecting protein DprA; Region: dprA; TIGR00732 585055010863 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 585055010864 active site 585055010865 catalytic residues [active] 585055010866 metal binding site [ion binding]; metal-binding site 585055010867 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 585055010868 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 585055010869 putative active site [active] 585055010870 substrate binding site [chemical binding]; other site 585055010871 putative cosubstrate binding site; other site 585055010872 catalytic site [active] 585055010873 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 585055010874 substrate binding site [chemical binding]; other site 585055010875 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 585055010876 putative RNA binding site [nucleotide binding]; other site 585055010877 16S rRNA methyltransferase B; Provisional; Region: PRK10901 585055010878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055010879 S-adenosylmethionine binding site [chemical binding]; other site 585055010880 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 585055010881 TrkA-N domain; Region: TrkA_N; pfam02254 585055010882 TrkA-C domain; Region: TrkA_C; pfam02080 585055010883 TrkA-N domain; Region: TrkA_N; pfam02254 585055010884 TrkA-C domain; Region: TrkA_C; pfam02080 585055010885 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 585055010886 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 585055010887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 585055010888 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 585055010889 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 585055010890 DNA binding residues [nucleotide binding] 585055010891 dimer interface [polypeptide binding]; other site 585055010892 metal binding site [ion binding]; metal-binding site 585055010893 hypothetical protein; Provisional; Region: PRK10203 585055010894 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 585055010895 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 585055010896 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 585055010897 alphaNTD homodimer interface [polypeptide binding]; other site 585055010898 alphaNTD - beta interaction site [polypeptide binding]; other site 585055010899 alphaNTD - beta' interaction site [polypeptide binding]; other site 585055010900 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 585055010901 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 585055010902 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 585055010903 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055010904 RNA binding surface [nucleotide binding]; other site 585055010905 30S ribosomal protein S11; Validated; Region: PRK05309 585055010906 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 585055010907 30S ribosomal protein S13; Region: bact_S13; TIGR03631 585055010908 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 585055010909 SecY translocase; Region: SecY; pfam00344 585055010910 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 585055010911 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 585055010912 23S rRNA binding site [nucleotide binding]; other site 585055010913 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 585055010914 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 585055010915 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 585055010916 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 585055010917 23S rRNA interface [nucleotide binding]; other site 585055010918 5S rRNA interface [nucleotide binding]; other site 585055010919 L27 interface [polypeptide binding]; other site 585055010920 L5 interface [polypeptide binding]; other site 585055010921 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 585055010922 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585055010923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585055010924 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 585055010925 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 585055010926 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 585055010927 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 585055010928 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 585055010929 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 585055010930 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 585055010931 RNA binding site [nucleotide binding]; other site 585055010932 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 585055010933 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 585055010934 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 585055010935 23S rRNA interface [nucleotide binding]; other site 585055010936 putative translocon interaction site; other site 585055010937 signal recognition particle (SRP54) interaction site; other site 585055010938 L23 interface [polypeptide binding]; other site 585055010939 trigger factor interaction site; other site 585055010940 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 585055010941 23S rRNA interface [nucleotide binding]; other site 585055010942 5S rRNA interface [nucleotide binding]; other site 585055010943 putative antibiotic binding site [chemical binding]; other site 585055010944 L25 interface [polypeptide binding]; other site 585055010945 L27 interface [polypeptide binding]; other site 585055010946 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 585055010947 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 585055010948 G-X-X-G motif; other site 585055010949 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 585055010950 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 585055010951 protein-rRNA interface [nucleotide binding]; other site 585055010952 putative translocon binding site; other site 585055010953 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 585055010954 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 585055010955 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 585055010956 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 585055010957 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 585055010958 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 585055010959 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 585055010960 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 585055010961 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585055010962 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585055010963 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 585055010964 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 585055010965 heme binding site [chemical binding]; other site 585055010966 ferroxidase pore; other site 585055010967 ferroxidase diiron center [ion binding]; other site 585055010968 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 585055010969 elongation factor Tu; Reviewed; Region: PRK00049 585055010970 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585055010971 G1 box; other site 585055010972 GEF interaction site [polypeptide binding]; other site 585055010973 GTP/Mg2+ binding site [chemical binding]; other site 585055010974 Switch I region; other site 585055010975 G2 box; other site 585055010976 G3 box; other site 585055010977 Switch II region; other site 585055010978 G4 box; other site 585055010979 G5 box; other site 585055010980 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585055010981 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585055010982 Antibiotic Binding Site [chemical binding]; other site 585055010983 elongation factor G; Reviewed; Region: PRK00007 585055010984 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 585055010985 G1 box; other site 585055010986 putative GEF interaction site [polypeptide binding]; other site 585055010987 GTP/Mg2+ binding site [chemical binding]; other site 585055010988 Switch I region; other site 585055010989 G2 box; other site 585055010990 G3 box; other site 585055010991 Switch II region; other site 585055010992 G4 box; other site 585055010993 G5 box; other site 585055010994 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 585055010995 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 585055010996 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 585055010997 30S ribosomal protein S7; Validated; Region: PRK05302 585055010998 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 585055010999 S17 interaction site [polypeptide binding]; other site 585055011000 S8 interaction site; other site 585055011001 16S rRNA interaction site [nucleotide binding]; other site 585055011002 streptomycin interaction site [chemical binding]; other site 585055011003 23S rRNA interaction site [nucleotide binding]; other site 585055011004 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 585055011005 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 585055011006 sulfur relay protein TusC; Validated; Region: PRK00211 585055011007 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 585055011008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 585055011009 YheO-like PAS domain; Region: PAS_6; pfam08348 585055011010 HTH domain; Region: HTH_22; pfam13309 585055011011 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 585055011012 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585055011013 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585055011014 phi X174 lysis protein; Provisional; Region: PRK02793 585055011015 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585055011016 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585055011017 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 585055011018 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 585055011019 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585055011020 TrkA-N domain; Region: TrkA_N; pfam02254 585055011021 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 585055011022 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 585055011023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055011024 Walker A/P-loop; other site 585055011025 ATP binding site [chemical binding]; other site 585055011026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585055011027 ABC transporter signature motif; other site 585055011028 Walker B; other site 585055011029 D-loop; other site 585055011030 ABC transporter; Region: ABC_tran_2; pfam12848 585055011031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585055011032 putative hydrolase; Provisional; Region: PRK10985 585055011033 hypothetical protein; Provisional; Region: PRK04966 585055011034 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 585055011035 active site 585055011036 hypothetical protein; Provisional; Region: PRK10738 585055011037 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 585055011038 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585055011039 ligand binding site [chemical binding]; other site 585055011040 flexible hinge region; other site 585055011041 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585055011042 putative switch regulator; other site 585055011043 non-specific DNA interactions [nucleotide binding]; other site 585055011044 DNA binding site [nucleotide binding] 585055011045 sequence specific DNA binding site [nucleotide binding]; other site 585055011046 putative cAMP binding site [chemical binding]; other site 585055011047 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 585055011048 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585055011049 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585055011050 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 585055011051 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585055011052 inhibitor-cofactor binding pocket; inhibition site 585055011053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055011054 catalytic residue [active] 585055011055 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 585055011056 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585055011057 glutamine binding [chemical binding]; other site 585055011058 catalytic triad [active] 585055011059 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 585055011060 cell filamentation protein Fic; Provisional; Region: PRK10347 585055011061 hypothetical protein; Provisional; Region: PRK10204 585055011062 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 585055011063 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585055011064 substrate binding site [chemical binding]; other site 585055011065 putative transporter; Provisional; Region: PRK03699 585055011066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055011067 putative substrate translocation pore; other site 585055011068 nitrite reductase subunit NirD; Provisional; Region: PRK14989 585055011069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055011070 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585055011071 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585055011072 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585055011073 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 585055011074 nitrite transporter NirC; Provisional; Region: PRK11562 585055011075 siroheme synthase; Provisional; Region: cysG; PRK10637 585055011076 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 585055011077 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 585055011078 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 585055011079 active site 585055011080 SAM binding site [chemical binding]; other site 585055011081 homodimer interface [polypeptide binding]; other site 585055011082 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 585055011083 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 585055011084 hypothetical protein; Provisional; Region: PHA02764 585055011085 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 585055011086 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 585055011087 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585055011088 dimer interface [polypeptide binding]; other site 585055011089 active site 585055011090 fructoselysine 3-epimerase; Provisional; Region: PRK09856 585055011091 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 585055011092 AP (apurinic/apyrimidinic) site pocket; other site 585055011093 DNA interaction; other site 585055011094 Metal-binding active site; metal-binding site 585055011095 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 585055011096 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055011097 substrate binding site [chemical binding]; other site 585055011098 ATP binding site [chemical binding]; other site 585055011099 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 585055011100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055011101 DNA-binding site [nucleotide binding]; DNA binding site 585055011102 UTRA domain; Region: UTRA; pfam07702 585055011103 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585055011104 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 585055011105 Protein of unknown function; Region: YhfT; pfam10797 585055011106 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 585055011107 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585055011108 active site 585055011109 substrate binding pocket [chemical binding]; other site 585055011110 homodimer interaction site [polypeptide binding]; other site 585055011111 putative mutase; Provisional; Region: PRK12383 585055011112 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 585055011113 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 585055011114 dimer interface [polypeptide binding]; other site 585055011115 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 585055011116 active site 585055011117 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585055011118 substrate binding site [chemical binding]; other site 585055011119 catalytic residue [active] 585055011120 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 585055011121 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 585055011122 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 585055011123 active site 585055011124 HIGH motif; other site 585055011125 dimer interface [polypeptide binding]; other site 585055011126 KMSKS motif; other site 585055011127 phosphoglycolate phosphatase; Provisional; Region: PRK13222 585055011128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055011129 motif II; other site 585055011130 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585055011131 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 585055011132 substrate binding site [chemical binding]; other site 585055011133 hexamer interface [polypeptide binding]; other site 585055011134 metal binding site [ion binding]; metal-binding site 585055011135 DNA adenine methylase; Provisional; Region: PRK10904 585055011136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 585055011137 cell division protein DamX; Validated; Region: PRK10905 585055011138 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 585055011139 active site 585055011140 dimer interface [polypeptide binding]; other site 585055011141 metal binding site [ion binding]; metal-binding site 585055011142 shikimate kinase; Reviewed; Region: aroK; PRK00131 585055011143 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585055011144 ADP binding site [chemical binding]; other site 585055011145 magnesium binding site [ion binding]; other site 585055011146 putative shikimate binding site; other site 585055011147 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 585055011148 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585055011149 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585055011150 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 585055011151 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 585055011152 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 585055011153 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 585055011154 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 585055011155 Transglycosylase; Region: Transgly; pfam00912 585055011156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585055011157 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 585055011158 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585055011159 ADP-ribose binding site [chemical binding]; other site 585055011160 dimer interface [polypeptide binding]; other site 585055011161 active site 585055011162 nudix motif; other site 585055011163 metal binding site [ion binding]; metal-binding site 585055011164 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 585055011165 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585055011166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055011167 motif II; other site 585055011168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055011169 RNA binding surface [nucleotide binding]; other site 585055011170 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 585055011171 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 585055011172 dimerization interface [polypeptide binding]; other site 585055011173 domain crossover interface; other site 585055011174 redox-dependent activation switch; other site 585055011175 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 585055011176 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 585055011177 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 585055011178 active site 585055011179 substrate-binding site [chemical binding]; other site 585055011180 metal-binding site [ion binding] 585055011181 ATP binding site [chemical binding]; other site 585055011182 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 585055011183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055011184 non-specific DNA binding site [nucleotide binding]; other site 585055011185 salt bridge; other site 585055011186 sequence-specific DNA binding site [nucleotide binding]; other site 585055011187 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 585055011188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055011189 dimerization interface [polypeptide binding]; other site 585055011190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055011191 dimer interface [polypeptide binding]; other site 585055011192 phosphorylation site [posttranslational modification] 585055011193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055011194 ATP binding site [chemical binding]; other site 585055011195 G-X-G motif; other site 585055011196 osmolarity response regulator; Provisional; Region: ompR; PRK09468 585055011197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055011198 active site 585055011199 phosphorylation site [posttranslational modification] 585055011200 intermolecular recognition site; other site 585055011201 dimerization interface [polypeptide binding]; other site 585055011202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055011203 DNA binding site [nucleotide binding] 585055011204 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 585055011205 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585055011206 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585055011207 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 585055011208 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 585055011209 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 585055011210 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 585055011211 RNA binding site [nucleotide binding]; other site 585055011212 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 585055011213 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 585055011214 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 585055011215 G1 box; other site 585055011216 GTP/Mg2+ binding site [chemical binding]; other site 585055011217 Switch I region; other site 585055011218 G2 box; other site 585055011219 G3 box; other site 585055011220 Switch II region; other site 585055011221 G4 box; other site 585055011222 G5 box; other site 585055011223 Nucleoside recognition; Region: Gate; pfam07670 585055011224 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 585055011225 Nucleoside recognition; Region: Gate; pfam07670 585055011226 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 585055011227 putative transposase; Provisional; Region: PRK09857 585055011228 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585055011229 carboxylesterase BioH; Provisional; Region: PRK10349 585055011230 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 585055011231 DNA utilization protein GntX; Provisional; Region: PRK11595 585055011232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055011233 active site 585055011234 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 585055011235 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 585055011236 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 585055011237 high-affinity gluconate transporter; Provisional; Region: PRK14984 585055011238 gluconate transporter; Region: gntP; TIGR00791 585055011239 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 585055011240 4-alpha-glucanotransferase; Region: malQ; TIGR00217 585055011241 maltodextrin phosphorylase; Provisional; Region: PRK14985 585055011242 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585055011243 homodimer interface [polypeptide binding]; other site 585055011244 active site pocket [active] 585055011245 transcriptional regulator MalT; Provisional; Region: PRK04841 585055011246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055011247 DNA binding residues [nucleotide binding] 585055011248 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 585055011249 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 585055011250 putative active site [active] 585055011251 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 585055011252 hypothetical protein; Reviewed; Region: PRK09588 585055011253 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 585055011254 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 585055011255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055011256 Walker A motif; other site 585055011257 ATP binding site [chemical binding]; other site 585055011258 Walker B motif; other site 585055011259 arginine finger; other site 585055011260 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 585055011261 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585055011262 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055011263 intramembrane serine protease GlpG; Provisional; Region: PRK10907 585055011264 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 585055011265 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585055011266 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 585055011267 active site residue [active] 585055011268 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 585055011269 hypothetical protein; Provisional; Region: PRK09781; cl08057 585055011270 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 585055011271 glycogen phosphorylase; Provisional; Region: PRK14986 585055011272 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585055011273 homodimer interface [polypeptide binding]; other site 585055011274 active site pocket [active] 585055011275 glycogen synthase; Provisional; Region: glgA; PRK00654 585055011276 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 585055011277 ADP-binding pocket [chemical binding]; other site 585055011278 homodimer interface [polypeptide binding]; other site 585055011279 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 585055011280 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 585055011281 ligand binding site; other site 585055011282 oligomer interface; other site 585055011283 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 585055011284 sulfate 1 binding site; other site 585055011285 glycogen debranching enzyme; Provisional; Region: PRK03705 585055011286 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 585055011287 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 585055011288 active site 585055011289 catalytic site [active] 585055011290 glycogen branching enzyme; Provisional; Region: PRK05402 585055011291 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 585055011292 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 585055011293 active site 585055011294 catalytic site [active] 585055011295 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 585055011296 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 585055011297 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585055011298 putative antibiotic transporter; Provisional; Region: PRK10739 585055011299 low affinity gluconate transporter; Provisional; Region: PRK10472 585055011300 gluconate transporter; Region: gntP; TIGR00791 585055011301 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 585055011302 ATP-binding site [chemical binding]; other site 585055011303 Gluconate-6-phosphate binding site [chemical binding]; other site 585055011304 Shikimate kinase; Region: SKI; pfam01202 585055011305 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 585055011306 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055011307 DNA binding site [nucleotide binding] 585055011308 domain linker motif; other site 585055011309 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585055011310 putative ligand binding site [chemical binding]; other site 585055011311 putative dimerization interface [polypeptide binding]; other site 585055011312 Pirin-related protein [General function prediction only]; Region: COG1741 585055011313 Pirin; Region: Pirin; pfam02678 585055011314 putative oxidoreductase; Provisional; Region: PRK10206 585055011315 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585055011316 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585055011317 putative acetyltransferase YhhY; Provisional; Region: PRK10140 585055011318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055011319 Coenzyme A binding pocket [chemical binding]; other site 585055011320 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 585055011321 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 585055011322 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 585055011323 hypothetical protein; Provisional; Region: PRK10350 585055011324 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 585055011325 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 585055011326 putative active site [active] 585055011327 catalytic site [active] 585055011328 putative metal binding site [ion binding]; other site 585055011329 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 585055011330 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585055011331 Walker A/P-loop; other site 585055011332 ATP binding site [chemical binding]; other site 585055011333 Q-loop/lid; other site 585055011334 ABC transporter signature motif; other site 585055011335 Walker B; other site 585055011336 D-loop; other site 585055011337 H-loop/switch region; other site 585055011338 TOBE domain; Region: TOBE_2; pfam08402 585055011339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585055011340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055011341 dimer interface [polypeptide binding]; other site 585055011342 conserved gate region; other site 585055011343 putative PBP binding loops; other site 585055011344 ABC-ATPase subunit interface; other site 585055011345 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 585055011346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055011347 dimer interface [polypeptide binding]; other site 585055011348 conserved gate region; other site 585055011349 putative PBP binding loops; other site 585055011350 ABC-ATPase subunit interface; other site 585055011351 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 585055011352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585055011353 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 585055011354 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 585055011355 Walker A/P-loop; other site 585055011356 ATP binding site [chemical binding]; other site 585055011357 Q-loop/lid; other site 585055011358 ABC transporter signature motif; other site 585055011359 Walker B; other site 585055011360 D-loop; other site 585055011361 H-loop/switch region; other site 585055011362 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 585055011363 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 585055011364 Walker A/P-loop; other site 585055011365 ATP binding site [chemical binding]; other site 585055011366 Q-loop/lid; other site 585055011367 ABC transporter signature motif; other site 585055011368 Walker B; other site 585055011369 D-loop; other site 585055011370 H-loop/switch region; other site 585055011371 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 585055011372 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 585055011373 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 585055011374 TM-ABC transporter signature motif; other site 585055011375 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055011376 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 585055011377 TM-ABC transporter signature motif; other site 585055011378 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585055011379 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585055011380 dimerization interface [polypeptide binding]; other site 585055011381 ligand binding site [chemical binding]; other site 585055011382 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 585055011383 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585055011384 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585055011385 dimerization interface [polypeptide binding]; other site 585055011386 ligand binding site [chemical binding]; other site 585055011387 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 585055011388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585055011389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585055011390 DNA binding residues [nucleotide binding] 585055011391 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 585055011392 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 585055011393 cell division protein FtsE; Provisional; Region: PRK10908 585055011394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055011395 Walker A/P-loop; other site 585055011396 ATP binding site [chemical binding]; other site 585055011397 Q-loop/lid; other site 585055011398 ABC transporter signature motif; other site 585055011399 Walker B; other site 585055011400 D-loop; other site 585055011401 H-loop/switch region; other site 585055011402 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 585055011403 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 585055011404 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585055011405 P loop; other site 585055011406 GTP binding site [chemical binding]; other site 585055011407 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 585055011408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055011409 S-adenosylmethionine binding site [chemical binding]; other site 585055011410 hypothetical protein; Provisional; Region: PRK10910 585055011411 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 585055011412 Predicted membrane protein [Function unknown]; Region: COG3714 585055011413 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 585055011414 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585055011415 metal-binding site [ion binding] 585055011416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585055011417 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 585055011418 CPxP motif; other site 585055011419 hypothetical protein; Provisional; Region: PRK11212 585055011420 hypothetical protein; Provisional; Region: PRK11615 585055011421 major facilitator superfamily transporter; Provisional; Region: PRK05122 585055011422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055011423 putative substrate translocation pore; other site 585055011424 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 585055011425 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585055011426 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 585055011427 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 585055011428 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585055011429 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 585055011430 substrate binding site [chemical binding]; other site 585055011431 nickel transporter permease NikB; Provisional; Region: PRK10352 585055011432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055011433 dimer interface [polypeptide binding]; other site 585055011434 conserved gate region; other site 585055011435 putative PBP binding loops; other site 585055011436 ABC-ATPase subunit interface; other site 585055011437 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 585055011438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055011439 dimer interface [polypeptide binding]; other site 585055011440 conserved gate region; other site 585055011441 putative PBP binding loops; other site 585055011442 ABC-ATPase subunit interface; other site 585055011443 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 585055011444 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055011445 Walker A/P-loop; other site 585055011446 ATP binding site [chemical binding]; other site 585055011447 Q-loop/lid; other site 585055011448 ABC transporter signature motif; other site 585055011449 Walker B; other site 585055011450 D-loop; other site 585055011451 H-loop/switch region; other site 585055011452 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585055011453 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 585055011454 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055011455 Walker A/P-loop; other site 585055011456 ATP binding site [chemical binding]; other site 585055011457 Q-loop/lid; other site 585055011458 ABC transporter signature motif; other site 585055011459 Walker B; other site 585055011460 D-loop; other site 585055011461 H-loop/switch region; other site 585055011462 nickel responsive regulator; Provisional; Region: PRK02967 585055011463 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 585055011464 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 585055011465 HicB family; Region: HicB; pfam05534 585055011466 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585055011467 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585055011468 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 585055011469 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585055011470 Walker A/P-loop; other site 585055011471 ATP binding site [chemical binding]; other site 585055011472 Q-loop/lid; other site 585055011473 ABC transporter signature motif; other site 585055011474 Walker B; other site 585055011475 D-loop; other site 585055011476 H-loop/switch region; other site 585055011477 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585055011478 Walker A/P-loop; other site 585055011479 ATP binding site [chemical binding]; other site 585055011480 Q-loop/lid; other site 585055011481 ABC transporter signature motif; other site 585055011482 Walker B; other site 585055011483 D-loop; other site 585055011484 H-loop/switch region; other site 585055011485 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585055011486 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585055011487 HlyD family secretion protein; Region: HlyD; pfam00529 585055011488 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055011489 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055011490 fragment of conserved hypothetical protein (part 2);Evidence 7 : Gene remnant 585055011491 fragment of conserved hypothetical protein (part 1);Evidence 7 : Gene remnant 585055011492 fragment of conserved hypothetical protein (part 2);Evidence 7 : Gene remnant 585055011493 fragment of conserved hypothetical protein (part 1);Evidence 7 : Gene remnant 585055011494 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055011495 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 585055011496 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 585055011497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055011498 dimerization interface [polypeptide binding]; other site 585055011499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055011500 dimer interface [polypeptide binding]; other site 585055011501 phosphorylation site [posttranslational modification] 585055011502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055011503 ATP binding site [chemical binding]; other site 585055011504 Mg2+ binding site [ion binding]; other site 585055011505 G-X-G motif; other site 585055011506 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 585055011507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055011508 active site 585055011509 phosphorylation site [posttranslational modification] 585055011510 intermolecular recognition site; other site 585055011511 dimerization interface [polypeptide binding]; other site 585055011512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055011513 DNA binding site [nucleotide binding] 585055011514 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 585055011515 CopC domain; Region: CopC; pfam04234 585055011516 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 585055011517 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 585055011518 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585055011519 Multicopper oxidase; Region: Cu-oxidase; pfam00394 585055011520 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585055011521 Peptidase family M23; Region: Peptidase_M23; pfam01551 585055011522 YHS domain; Region: YHS; pfam04945 585055011523 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 585055011524 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585055011525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055011526 motif II; other site 585055011527 Protein of unknown function, DUF; Region: DUF411; cl01142 585055011528 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 585055011529 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 585055011530 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055011531 periplasmic copper-binding protein; Provisional; Region: PRK09838 585055011532 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 585055011533 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 585055011534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055011535 active site 585055011536 phosphorylation site [posttranslational modification] 585055011537 intermolecular recognition site; other site 585055011538 dimerization interface [polypeptide binding]; other site 585055011539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055011540 DNA binding site [nucleotide binding] 585055011541 sensor kinase CusS; Provisional; Region: PRK09835 585055011542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055011543 dimerization interface [polypeptide binding]; other site 585055011544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055011545 dimer interface [polypeptide binding]; other site 585055011546 phosphorylation site [posttranslational modification] 585055011547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055011548 ATP binding site [chemical binding]; other site 585055011549 Mg2+ binding site [ion binding]; other site 585055011550 G-X-G motif; other site 585055011551 Domain of unknown function (DUF305); Region: DUF305; cl17794 585055011552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055011553 Walker A/P-loop; other site 585055011554 ATP binding site [chemical binding]; other site 585055011555 AAA ATPase domain; Region: AAA_15; pfam13175 585055011556 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 585055011557 active site 585055011558 metal binding site [ion binding]; metal-binding site 585055011559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055011560 salt bridge; other site 585055011561 non-specific DNA binding site [nucleotide binding]; other site 585055011562 sequence-specific DNA binding site [nucleotide binding]; other site 585055011563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055011564 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055011565 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055011566 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055011567 TniQ; Region: TniQ; pfam06527 585055011568 AAA ATPase domain; Region: AAA_16; pfam13191 585055011569 AAA domain; Region: AAA_22; pfam13401 585055011570 Integrase core domain; Region: rve; cl01316 585055011571 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 585055011572 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 585055011573 Predicted flavoproteins [General function prediction only]; Region: COG2081 585055011574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055011575 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585055011576 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585055011577 universal stress protein UspB; Provisional; Region: PRK04960 585055011578 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585055011579 Ligand Binding Site [chemical binding]; other site 585055011580 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 585055011581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055011582 putative substrate translocation pore; other site 585055011583 POT family; Region: PTR2; pfam00854 585055011584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055011585 S-adenosylmethionine binding site [chemical binding]; other site 585055011586 oligopeptidase A; Provisional; Region: PRK10911 585055011587 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585055011588 active site 585055011589 Zn binding site [ion binding]; other site 585055011590 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 585055011591 glutathione reductase; Validated; Region: PRK06116 585055011592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055011593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055011594 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585055011595 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055011596 dimerization interface [polypeptide binding]; other site 585055011597 putative DNA binding site [nucleotide binding]; other site 585055011598 putative Zn2+ binding site [ion binding]; other site 585055011599 arsenical pump membrane protein; Provisional; Region: PRK15445 585055011600 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 585055011601 transmembrane helices; other site 585055011602 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585055011603 ArsC family; Region: ArsC; pfam03960 585055011604 catalytic residues [active] 585055011605 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055011606 dimerization interface [polypeptide binding]; other site 585055011607 putative DNA binding site [nucleotide binding]; other site 585055011608 putative Zn2+ binding site [ion binding]; other site 585055011609 Predicted permeases [General function prediction only]; Region: COG0701 585055011610 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 585055011611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585055011612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055011613 DNA binding residues [nucleotide binding] 585055011614 dimerization interface [polypeptide binding]; other site 585055011615 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 585055011616 MgtC family; Region: MgtC; pfam02308 585055011617 acid-resistance protein; Provisional; Region: hdeB; PRK11566 585055011618 acid-resistance protein; Provisional; Region: PRK10208 585055011619 acid-resistance membrane protein; Provisional; Region: PRK10209 585055011620 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 585055011621 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585055011622 pyruvate kinase; Provisional; Region: PRK05826 585055011623 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 585055011624 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055011625 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055011626 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585055011627 Protein export membrane protein; Region: SecD_SecF; cl14618 585055011628 transcriptional regulator YdeO; Provisional; Region: PRK09940 585055011629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055011630 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 585055011631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055011632 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585055011633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055011634 catalytic residue [active] 585055011635 Haem-binding domain; Region: Haem_bd; pfam14376 585055011636 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 585055011637 trehalase; Provisional; Region: treF; PRK13270 585055011638 Trehalase; Region: Trehalase; pfam01204 585055011639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585055011640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055011641 DNA binding residues [nucleotide binding] 585055011642 dimerization interface [polypeptide binding]; other site 585055011643 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055011644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055011645 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 585055011646 putative effector binding pocket; other site 585055011647 putative dimerization interface [polypeptide binding]; other site 585055011648 inner membrane protein YhjD; Region: TIGR00766 585055011649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055011650 metabolite-proton symporter; Region: 2A0106; TIGR00883 585055011651 putative substrate translocation pore; other site 585055011652 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 585055011653 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585055011654 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055011655 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055011656 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585055011657 substrate binding site [chemical binding]; other site 585055011658 ATP binding site [chemical binding]; other site 585055011659 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585055011660 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585055011661 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 585055011662 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585055011663 putative diguanylate cyclase; Provisional; Region: PRK13561 585055011664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585055011665 metal binding site [ion binding]; metal-binding site 585055011666 active site 585055011667 I-site; other site 585055011668 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055011669 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 585055011670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055011671 binding surface 585055011672 TPR motif; other site 585055011673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055011674 binding surface 585055011675 TPR motif; other site 585055011676 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 585055011677 endo-1,4-D-glucanase; Provisional; Region: PRK11097 585055011678 cellulose synthase regulator protein; Provisional; Region: PRK11114 585055011679 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 585055011680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585055011681 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 585055011682 DXD motif; other site 585055011683 PilZ domain; Region: PilZ; pfam07238 585055011684 cell division protein; Provisional; Region: PRK10037 585055011685 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 585055011686 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 585055011687 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 585055011688 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 585055011689 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 585055011690 fragment of toxic polypeptide, small (partial);Evidence 7 : Gene remnant; Product type f : factor 585055011691 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585055011692 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585055011693 serine transporter; Region: stp; TIGR00814 585055011694 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 585055011695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055011696 Walker A/P-loop; other site 585055011697 ATP binding site [chemical binding]; other site 585055011698 Q-loop/lid; other site 585055011699 ABC transporter signature motif; other site 585055011700 Walker B; other site 585055011701 D-loop; other site 585055011702 H-loop/switch region; other site 585055011703 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585055011704 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 585055011705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055011706 Walker A/P-loop; other site 585055011707 ATP binding site [chemical binding]; other site 585055011708 Q-loop/lid; other site 585055011709 ABC transporter signature motif; other site 585055011710 Walker B; other site 585055011711 D-loop; other site 585055011712 H-loop/switch region; other site 585055011713 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585055011714 dipeptide transporter; Provisional; Region: PRK10913 585055011715 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585055011716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055011717 dimer interface [polypeptide binding]; other site 585055011718 conserved gate region; other site 585055011719 putative PBP binding loops; other site 585055011720 ABC-ATPase subunit interface; other site 585055011721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585055011722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055011723 dimer interface [polypeptide binding]; other site 585055011724 conserved gate region; other site 585055011725 putative PBP binding loops; other site 585055011726 ABC-ATPase subunit interface; other site 585055011727 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585055011728 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585055011729 peptide binding site [polypeptide binding]; other site 585055011730 phosphoethanolamine transferase; Provisional; Region: PRK11560 585055011731 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585055011732 Sulfatase; Region: Sulfatase; pfam00884 585055011733 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 585055011734 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 585055011735 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 585055011736 PapC N-terminal domain; Region: PapC_N; pfam13954 585055011737 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055011738 PapC C-terminal domain; Region: PapC_C; pfam13953 585055011739 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 585055011740 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055011741 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055011742 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 585055011743 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 585055011744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055011745 putative substrate translocation pore; other site 585055011746 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 585055011747 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 585055011748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585055011749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055011750 Coenzyme A binding pocket [chemical binding]; other site 585055011751 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585055011752 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585055011753 molybdopterin cofactor binding site [chemical binding]; other site 585055011754 substrate binding site [chemical binding]; other site 585055011755 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585055011756 molybdopterin cofactor binding site; other site 585055011757 putative outer membrane lipoprotein; Provisional; Region: PRK10510 585055011758 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585055011759 ligand binding site [chemical binding]; other site 585055011760 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 585055011761 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 585055011762 dimerization interface [polypeptide binding]; other site 585055011763 ligand binding site [chemical binding]; other site 585055011764 NADP binding site [chemical binding]; other site 585055011765 catalytic site [active] 585055011766 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 585055011767 Predicted transcriptional regulator [Transcription]; Region: COG2944 585055011768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055011769 non-specific DNA binding site [nucleotide binding]; other site 585055011770 salt bridge; other site 585055011771 sequence-specific DNA binding site [nucleotide binding]; other site 585055011772 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585055011773 DNA-binding site [nucleotide binding]; DNA binding site 585055011774 RNA-binding motif; other site 585055011775 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 585055011776 DALR anticodon binding domain; Region: DALR_1; pfam05746 585055011777 anticodon binding site; other site 585055011778 tRNA binding surface [nucleotide binding]; other site 585055011779 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 585055011780 dimer interface [polypeptide binding]; other site 585055011781 motif 1; other site 585055011782 active site 585055011783 motif 2; other site 585055011784 motif 3; other site 585055011785 YsaB-like lipoprotein; Region: YsaB; pfam13983 585055011786 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 585055011787 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585055011788 hypothetical protein; Provisional; Region: PRK11383 585055011789 yiaA/B two helix domain; Region: YiaAB; pfam05360 585055011790 yiaA/B two helix domain; Region: YiaAB; pfam05360 585055011791 hypothetical protein; Provisional; Region: PRK11403 585055011792 yiaA/B two helix domain; Region: YiaAB; pfam05360 585055011793 xylulokinase; Provisional; Region: PRK15027 585055011794 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 585055011795 N- and C-terminal domain interface [polypeptide binding]; other site 585055011796 active site 585055011797 MgATP binding site [chemical binding]; other site 585055011798 catalytic site [active] 585055011799 metal binding site [ion binding]; metal-binding site 585055011800 xylulose binding site [chemical binding]; other site 585055011801 homodimer interface [polypeptide binding]; other site 585055011802 xylose isomerase; Provisional; Region: PRK05474 585055011803 xylose isomerase; Region: xylose_isom_A; TIGR02630 585055011804 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 585055011805 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 585055011806 putative ligand binding site [chemical binding]; other site 585055011807 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 585055011808 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055011809 Walker A/P-loop; other site 585055011810 ATP binding site [chemical binding]; other site 585055011811 Q-loop/lid; other site 585055011812 ABC transporter signature motif; other site 585055011813 Walker B; other site 585055011814 D-loop; other site 585055011815 H-loop/switch region; other site 585055011816 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055011817 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055011818 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055011819 TM-ABC transporter signature motif; other site 585055011820 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 585055011821 putative dimerization interface [polypeptide binding]; other site 585055011822 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585055011823 putative ligand binding site [chemical binding]; other site 585055011824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055011825 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055011826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055011827 hypothetical protein; Provisional; Region: PRK10356 585055011828 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 585055011829 alpha-amylase; Reviewed; Region: malS; PRK09505 585055011830 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 585055011831 active site 585055011832 catalytic site [active] 585055011833 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 585055011834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055011835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055011836 homodimer interface [polypeptide binding]; other site 585055011837 catalytic residue [active] 585055011838 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585055011839 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585055011840 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585055011841 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585055011842 Bacterial transcriptional regulator; Region: IclR; pfam01614 585055011843 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 585055011844 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 585055011845 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 585055011846 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 585055011847 DctM-like transporters; Region: DctM; pfam06808 585055011848 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585055011849 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585055011850 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585055011851 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 585055011852 putative N- and C-terminal domain interface [polypeptide binding]; other site 585055011853 putative active site [active] 585055011854 MgATP binding site [chemical binding]; other site 585055011855 catalytic site [active] 585055011856 metal binding site [ion binding]; metal-binding site 585055011857 putative xylulose binding site [chemical binding]; other site 585055011858 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585055011859 active site 585055011860 dimer interface [polypeptide binding]; other site 585055011861 magnesium binding site [ion binding]; other site 585055011862 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 585055011863 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585055011864 AP (apurinic/apyrimidinic) site pocket; other site 585055011865 DNA interaction; other site 585055011866 Metal-binding active site; metal-binding site 585055011867 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585055011868 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585055011869 intersubunit interface [polypeptide binding]; other site 585055011870 active site 585055011871 Zn2+ binding site [ion binding]; other site 585055011872 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585055011873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585055011874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055011875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585055011876 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585055011877 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055011878 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055011879 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585055011880 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 585055011881 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585055011882 NAD(P) binding site [chemical binding]; other site 585055011883 catalytic residues [active] 585055011884 putative alcohol dehydrogenase; Provisional; Region: PRK09860 585055011885 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585055011886 dimer interface [polypeptide binding]; other site 585055011887 active site 585055011888 metal binding site [ion binding]; metal-binding site 585055011889 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 585055011890 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 585055011891 G1 box; other site 585055011892 putative GEF interaction site [polypeptide binding]; other site 585055011893 GTP/Mg2+ binding site [chemical binding]; other site 585055011894 Switch I region; other site 585055011895 G2 box; other site 585055011896 G3 box; other site 585055011897 Switch II region; other site 585055011898 G4 box; other site 585055011899 G5 box; other site 585055011900 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 585055011901 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 585055011902 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 585055011903 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 585055011904 selenocysteine synthase; Provisional; Region: PRK04311 585055011905 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 585055011906 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 585055011907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585055011908 catalytic residue [active] 585055011909 putative glutathione S-transferase; Provisional; Region: PRK10357 585055011910 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 585055011911 putative C-terminal domain interface [polypeptide binding]; other site 585055011912 putative GSH binding site (G-site) [chemical binding]; other site 585055011913 putative dimer interface [polypeptide binding]; other site 585055011914 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 585055011915 dimer interface [polypeptide binding]; other site 585055011916 N-terminal domain interface [polypeptide binding]; other site 585055011917 putative substrate binding pocket (H-site) [chemical binding]; other site 585055011918 PAAR motif; Region: PAAR_motif; cl15808 585055011919 RHS Repeat; Region: RHS_repeat; pfam05593 585055011920 RHS Repeat; Region: RHS_repeat; pfam05593 585055011921 RHS Repeat; Region: RHS_repeat; cl11982 585055011922 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055011923 RHS Repeat; Region: RHS_repeat; pfam05593 585055011924 RHS Repeat; Region: RHS_repeat; pfam05593 585055011925 RHS protein; Region: RHS; pfam03527 585055011926 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055011927 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 585055011928 fragment of lyase containing HEAT-repeat (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055011929 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055011930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055011931 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055011932 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055011933 fragment of lyase containing HEAT-repeat (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055011934 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055011935 RHS protein; Region: RHS; pfam03527 585055011936 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055011937 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585055011938 fragment of conserved hypothetical protein (partial);Evidence 7 : Gene remnant 585055011939 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585055011940 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055011941 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055011942 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585055011943 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 585055011944 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585055011945 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585055011946 active site 585055011947 P-loop; other site 585055011948 phosphorylation site [posttranslational modification] 585055011949 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055011950 active site 585055011951 phosphorylation site [posttranslational modification] 585055011952 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 585055011953 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585055011954 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585055011955 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585055011956 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 585055011957 hypothetical protein; Provisional; Region: PRK11020 585055011958 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 585055011959 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585055011960 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585055011961 trimer interface [polypeptide binding]; other site 585055011962 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585055011963 trimer interface [polypeptide binding]; other site 585055011964 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 585055011965 Haemagglutinin; Region: HIM; pfam05662 585055011966 Haemagglutinin; Region: HIM; pfam05662 585055011967 YadA-like C-terminal region; Region: YadA; pfam03895 585055011968 L-lactate permease; Provisional; Region: PRK10420 585055011969 glycolate transporter; Provisional; Region: PRK09695 585055011970 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 585055011971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055011972 DNA-binding site [nucleotide binding]; DNA binding site 585055011973 FCD domain; Region: FCD; pfam07729 585055011974 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 585055011975 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585055011976 phosphate binding site [ion binding]; other site 585055011977 putative rRNA methylase; Provisional; Region: PRK10358 585055011978 serine acetyltransferase; Provisional; Region: cysE; PRK11132 585055011979 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 585055011980 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585055011981 trimer interface [polypeptide binding]; other site 585055011982 active site 585055011983 substrate binding site [chemical binding]; other site 585055011984 CoA binding site [chemical binding]; other site 585055011985 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 585055011986 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585055011987 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 585055011988 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 585055011989 SecA binding site; other site 585055011990 Preprotein binding site; other site 585055011991 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 585055011992 GSH binding site [chemical binding]; other site 585055011993 catalytic residues [active] 585055011994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585055011995 active site residue [active] 585055011996 phosphoglyceromutase; Provisional; Region: PRK05434 585055011997 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 585055011998 AmiB activator; Provisional; Region: PRK11637 585055011999 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585055012000 Peptidase family M23; Region: Peptidase_M23; pfam01551 585055012001 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 585055012002 NodB motif; other site 585055012003 putative active site [active] 585055012004 putative catalytic site [active] 585055012005 Zn binding site [ion binding]; other site 585055012006 putative glycosyl transferase; Provisional; Region: PRK10073 585055012007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585055012008 active site 585055012009 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 585055012010 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585055012011 NAD(P) binding site [chemical binding]; other site 585055012012 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585055012013 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585055012014 substrate-cofactor binding pocket; other site 585055012015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055012016 catalytic residue [active] 585055012017 hypothetical protein; Provisional; Region: PRK11346 585055012018 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 585055012019 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 585055012020 NADP binding site [chemical binding]; other site 585055012021 homopentamer interface [polypeptide binding]; other site 585055012022 substrate binding site [chemical binding]; other site 585055012023 active site 585055012024 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585055012025 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585055012026 putative active site [active] 585055012027 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585055012028 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585055012029 putative active site [active] 585055012030 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 585055012031 O-antigen ligase RfaL; Provisional; Region: PRK15487 585055012032 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 585055012033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585055012034 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585055012035 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 585055012036 Ligand binding site; other site 585055012037 metal-binding site 585055012038 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585055012039 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 585055012040 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 585055012041 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585055012042 Ligand binding site; other site 585055012043 metal-binding site 585055012044 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585055012045 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 585055012046 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585055012047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585055012048 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 585055012049 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585055012050 putative active site [active] 585055012051 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 585055012052 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 585055012053 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585055012054 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 585055012055 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 585055012056 active site 585055012057 (T/H)XGH motif; other site 585055012058 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 585055012059 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 585055012060 DNA binding site [nucleotide binding] 585055012061 catalytic residue [active] 585055012062 H2TH interface [polypeptide binding]; other site 585055012063 putative catalytic residues [active] 585055012064 turnover-facilitating residue; other site 585055012065 intercalation triad [nucleotide binding]; other site 585055012066 8OG recognition residue [nucleotide binding]; other site 585055012067 putative reading head residues; other site 585055012068 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585055012069 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585055012070 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 585055012071 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 585055012072 hypothetical protein; Reviewed; Region: PRK00024 585055012073 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585055012074 MPN+ (JAMM) motif; other site 585055012075 Zinc-binding site [ion binding]; other site 585055012076 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 585055012077 Flavoprotein; Region: Flavoprotein; pfam02441 585055012078 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 585055012079 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585055012080 trimer interface [polypeptide binding]; other site 585055012081 active site 585055012082 division inhibitor protein; Provisional; Region: slmA; PRK09480 585055012083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055012084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585055012085 active site 585055012086 ribonuclease PH; Reviewed; Region: rph; PRK00173 585055012087 Ribonuclease PH; Region: RNase_PH_bact; cd11362 585055012088 hexamer interface [polypeptide binding]; other site 585055012089 active site 585055012090 hypothetical protein; Provisional; Region: PRK11820 585055012091 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 585055012092 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 585055012093 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 585055012094 BRO family, N-terminal domain; Region: Bro-N; pfam02498 585055012095 Predicted membrane protein [Function unknown]; Region: COG2860 585055012096 UPF0126 domain; Region: UPF0126; pfam03458 585055012097 UPF0126 domain; Region: UPF0126; pfam03458 585055012098 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 585055012099 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 585055012100 nucleotide binding pocket [chemical binding]; other site 585055012101 K-X-D-G motif; other site 585055012102 catalytic site [active] 585055012103 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585055012104 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 585055012105 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 585055012106 catalytic site [active] 585055012107 G-X2-G-X-G-K; other site 585055012108 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 585055012109 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 585055012110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585055012111 Zn2+ binding site [ion binding]; other site 585055012112 Mg2+ binding site [ion binding]; other site 585055012113 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585055012114 synthetase active site [active] 585055012115 NTP binding site [chemical binding]; other site 585055012116 metal binding site [ion binding]; metal-binding site 585055012117 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585055012118 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585055012119 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 585055012120 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585055012121 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 585055012122 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 585055012123 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 585055012124 generic binding surface II; other site 585055012125 ssDNA binding site; other site 585055012126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055012127 ATP binding site [chemical binding]; other site 585055012128 putative Mg++ binding site [ion binding]; other site 585055012129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055012130 nucleotide binding region [chemical binding]; other site 585055012131 ATP-binding site [chemical binding]; other site 585055012132 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 585055012133 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 585055012134 AsmA family; Region: AsmA; pfam05170 585055012135 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 585055012136 putative alpha-glucosidase; Provisional; Region: PRK10658 585055012137 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 585055012138 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 585055012139 active site 585055012140 homotrimer interface [polypeptide binding]; other site 585055012141 catalytic site [active] 585055012142 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 585055012143 putative transporter; Provisional; Region: PRK11462 585055012144 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 585055012145 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 585055012146 sugar efflux transporter; Region: 2A0120; TIGR00899 585055012147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012148 putative substrate translocation pore; other site 585055012149 EamA-like transporter family; Region: EamA; pfam00892 585055012150 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585055012151 EamA-like transporter family; Region: EamA; pfam00892 585055012152 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 585055012153 lipoprotein, YaeC family; Region: TIGR00363 585055012154 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 585055012155 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 585055012156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012157 putative substrate translocation pore; other site 585055012158 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 585055012159 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585055012160 cryptic adenine deaminase; Provisional; Region: PRK10027 585055012161 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585055012162 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 585055012163 active site 585055012164 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 585055012165 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 585055012166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012167 putative substrate translocation pore; other site 585055012168 regulatory protein UhpC; Provisional; Region: PRK11663 585055012169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012170 putative substrate translocation pore; other site 585055012171 sensory histidine kinase UhpB; Provisional; Region: PRK11644 585055012172 MASE1; Region: MASE1; pfam05231 585055012173 Histidine kinase; Region: HisKA_3; pfam07730 585055012174 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 585055012175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055012176 active site 585055012177 phosphorylation site [posttranslational modification] 585055012178 intermolecular recognition site; other site 585055012179 dimerization interface [polypeptide binding]; other site 585055012180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055012181 DNA binding residues [nucleotide binding] 585055012182 dimerization interface [polypeptide binding]; other site 585055012183 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 585055012184 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585055012185 putative valine binding site [chemical binding]; other site 585055012186 dimer interface [polypeptide binding]; other site 585055012187 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 585055012188 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585055012189 PYR/PP interface [polypeptide binding]; other site 585055012190 dimer interface [polypeptide binding]; other site 585055012191 TPP binding site [chemical binding]; other site 585055012192 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585055012193 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585055012194 TPP-binding site [chemical binding]; other site 585055012195 dimer interface [polypeptide binding]; other site 585055012196 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 585055012197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012198 putative substrate translocation pore; other site 585055012199 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585055012200 Domain of unknown function (DUF202); Region: DUF202; pfam02656 585055012201 Predicted membrane protein [Function unknown]; Region: COG2149 585055012202 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585055012203 Sulfatase; Region: Sulfatase; pfam00884 585055012204 putative transporter; Provisional; Region: PRK10484 585055012205 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 585055012206 Na binding site [ion binding]; other site 585055012207 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585055012208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055012209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055012210 fragment of 6-phospho-glucosidase (part 2);Evidence 7 : Gene remnant; Product type e : enzyme 585055012211 fragment of 6-phospho-glucosidase (part 1);Evidence 7 : Gene remnant; Product type e : enzyme 585055012212 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 585055012213 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585055012214 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055012215 active site turn [active] 585055012216 phosphorylation site [posttranslational modification] 585055012217 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585055012218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055012219 DNA-binding site [nucleotide binding]; DNA binding site 585055012220 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 585055012221 putative transporter; Validated; Region: PRK03818 585055012222 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585055012223 TrkA-C domain; Region: TrkA_C; pfam02080 585055012224 TrkA-C domain; Region: TrkA_C; pfam02080 585055012225 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585055012226 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585055012227 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585055012228 putative dimer interface [polypeptide binding]; other site 585055012229 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585055012230 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585055012231 putative dimer interface [polypeptide binding]; other site 585055012232 hypothetical protein; Provisional; Region: PRK11616 585055012233 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 585055012234 putative oxidoreductase; Provisional; Region: PRK11445 585055012235 hypothetical protein; Provisional; Region: PRK07236 585055012236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012237 D-galactonate transporter; Region: 2A0114; TIGR00893 585055012238 putative substrate translocation pore; other site 585055012239 galactonate dehydratase; Provisional; Region: PRK14017 585055012240 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 585055012241 putative active site pocket [active] 585055012242 putative metal binding site [ion binding]; other site 585055012243 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 585055012244 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585055012245 active site 585055012246 intersubunit interface [polypeptide binding]; other site 585055012247 catalytic residue [active] 585055012248 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 585055012249 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 585055012250 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585055012251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055012252 DNA-binding site [nucleotide binding]; DNA binding site 585055012253 FCD domain; Region: FCD; pfam07729 585055012254 hypothetical protein; Provisional; Region: PRK10215 585055012255 sugar phosphate phosphatase; Provisional; Region: PRK10513 585055012256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055012257 active site 585055012258 motif I; other site 585055012259 motif II; other site 585055012260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055012261 hypothetical protein; Provisional; Region: PRK11426 585055012262 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 585055012263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055012264 Mg2+ binding site [ion binding]; other site 585055012265 G-X-G motif; other site 585055012266 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585055012267 anchoring element; other site 585055012268 dimer interface [polypeptide binding]; other site 585055012269 ATP binding site [chemical binding]; other site 585055012270 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 585055012271 active site 585055012272 putative metal-binding site [ion binding]; other site 585055012273 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585055012274 recF protein; Region: recf; TIGR00611 585055012275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055012276 Walker A/P-loop; other site 585055012277 ATP binding site [chemical binding]; other site 585055012278 Q-loop/lid; other site 585055012279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055012280 ABC transporter signature motif; other site 585055012281 Walker B; other site 585055012282 D-loop; other site 585055012283 H-loop/switch region; other site 585055012284 DNA polymerase III subunit beta; Validated; Region: PRK05643 585055012285 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 585055012286 putative DNA binding surface [nucleotide binding]; other site 585055012287 dimer interface [polypeptide binding]; other site 585055012288 beta-clamp/clamp loader binding surface; other site 585055012289 beta-clamp/translesion DNA polymerase binding surface; other site 585055012290 DnaA N-terminal domain; Region: DnaA_N; pfam11638 585055012291 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 585055012292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055012293 Walker A motif; other site 585055012294 ATP binding site [chemical binding]; other site 585055012295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585055012296 Walker B motif; other site 585055012297 arginine finger; other site 585055012298 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 585055012299 DnaA box-binding interface [nucleotide binding]; other site 585055012300 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 585055012301 ribonuclease P; Reviewed; Region: rnpA; PRK01732 585055012302 hypothetical protein; Validated; Region: PRK00041 585055012303 membrane protein insertase; Provisional; Region: PRK01318 585055012304 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 585055012305 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 585055012306 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 585055012307 trmE is a tRNA modification GTPase; Region: trmE; cd04164 585055012308 G1 box; other site 585055012309 GTP/Mg2+ binding site [chemical binding]; other site 585055012310 Switch I region; other site 585055012311 G2 box; other site 585055012312 Switch II region; other site 585055012313 G3 box; other site 585055012314 G4 box; other site 585055012315 G5 box; other site 585055012316 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 585055012317 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 585055012318 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 585055012319 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585055012320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585055012321 catalytic residue [active] 585055012322 tryptophan permease TnaB; Provisional; Region: PRK09664 585055012323 aromatic amino acid transport protein; Region: araaP; TIGR00837 585055012324 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 585055012325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012326 putative substrate translocation pore; other site 585055012327 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 585055012328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055012329 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585055012330 substrate binding pocket [chemical binding]; other site 585055012331 dimerization interface [polypeptide binding]; other site 585055012332 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 585055012333 Predicted flavoprotein [General function prediction only]; Region: COG0431 585055012334 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585055012335 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585055012336 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 585055012337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055012338 active site 585055012339 motif I; other site 585055012340 motif II; other site 585055012341 putative inner membrane protein; Provisional; Region: PRK09823 585055012342 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 585055012343 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585055012344 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585055012345 active site 585055012346 trimer interface [polypeptide binding]; other site 585055012347 allosteric site; other site 585055012348 active site lid [active] 585055012349 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 585055012350 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 585055012351 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585055012352 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585055012353 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585055012354 trimer interface; other site 585055012355 sugar binding site [chemical binding]; other site 585055012356 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 585055012357 beta-galactosidase; Region: BGL; TIGR03356 585055012358 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 585055012359 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055012360 active site turn [active] 585055012361 phosphorylation site [posttranslational modification] 585055012362 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585055012363 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585055012364 HPr interaction site; other site 585055012365 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585055012366 active site 585055012367 phosphorylation site [posttranslational modification] 585055012368 fragment of transcriptional antiterminator of the bgl operon (part 2);Evidence 7 : Gene remnant; Product type r : regulator 585055012369 fragment of transcriptional antiterminator of the bgl operon (part 1);Evidence 7 : Gene remnant; Product type r : regulator 585055012370 transcriptional regulator PhoU; Provisional; Region: PRK11115 585055012371 PhoU domain; Region: PhoU; pfam01895 585055012372 PhoU domain; Region: PhoU; pfam01895 585055012373 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 585055012374 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 585055012375 Walker A/P-loop; other site 585055012376 ATP binding site [chemical binding]; other site 585055012377 Q-loop/lid; other site 585055012378 ABC transporter signature motif; other site 585055012379 Walker B; other site 585055012380 D-loop; other site 585055012381 H-loop/switch region; other site 585055012382 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 585055012383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055012384 dimer interface [polypeptide binding]; other site 585055012385 conserved gate region; other site 585055012386 putative PBP binding loops; other site 585055012387 ABC-ATPase subunit interface; other site 585055012388 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 585055012389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055012390 dimer interface [polypeptide binding]; other site 585055012391 conserved gate region; other site 585055012392 putative PBP binding loops; other site 585055012393 ABC-ATPase subunit interface; other site 585055012394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055012395 Fimbrial protein; Region: Fimbrial; cl01416 585055012396 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585055012397 PapC N-terminal domain; Region: PapC_N; pfam13954 585055012398 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585055012399 PapC C-terminal domain; Region: PapC_C; pfam13953 585055012400 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 585055012401 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585055012402 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585055012403 fimbrial protein; Provisional; Region: lpfA; PRK15289 585055012404 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 585055012405 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 585055012406 glutaminase active site [active] 585055012407 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585055012408 dimer interface [polypeptide binding]; other site 585055012409 active site 585055012410 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585055012411 dimer interface [polypeptide binding]; other site 585055012412 active site 585055012413 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 585055012414 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 585055012415 Substrate binding site; other site 585055012416 Mg++ binding site; other site 585055012417 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 585055012418 active site 585055012419 substrate binding site [chemical binding]; other site 585055012420 CoA binding site [chemical binding]; other site 585055012421 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 585055012422 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 585055012423 gamma subunit interface [polypeptide binding]; other site 585055012424 epsilon subunit interface [polypeptide binding]; other site 585055012425 LBP interface [polypeptide binding]; other site 585055012426 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 585055012427 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585055012428 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 585055012429 alpha subunit interaction interface [polypeptide binding]; other site 585055012430 Walker A motif; other site 585055012431 ATP binding site [chemical binding]; other site 585055012432 Walker B motif; other site 585055012433 inhibitor binding site; inhibition site 585055012434 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585055012435 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 585055012436 core domain interface [polypeptide binding]; other site 585055012437 delta subunit interface [polypeptide binding]; other site 585055012438 epsilon subunit interface [polypeptide binding]; other site 585055012439 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 585055012440 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585055012441 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 585055012442 beta subunit interaction interface [polypeptide binding]; other site 585055012443 Walker A motif; other site 585055012444 ATP binding site [chemical binding]; other site 585055012445 Walker B motif; other site 585055012446 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585055012447 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 585055012448 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 585055012449 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 585055012450 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 585055012451 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 585055012452 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 585055012453 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 585055012454 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 585055012455 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 585055012456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055012457 S-adenosylmethionine binding site [chemical binding]; other site 585055012458 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 585055012459 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 585055012460 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 585055012461 FMN-binding protein MioC; Provisional; Region: PRK09004 585055012462 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 585055012463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055012464 putative DNA binding site [nucleotide binding]; other site 585055012465 putative Zn2+ binding site [ion binding]; other site 585055012466 AsnC family; Region: AsnC_trans_reg; pfam01037 585055012467 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 585055012468 dimer interface [polypeptide binding]; other site 585055012469 active site 585055012470 hypothetical protein; Provisional; Region: yieM; PRK10997 585055012471 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585055012472 metal ion-dependent adhesion site (MIDAS); other site 585055012473 regulatory ATPase RavA; Provisional; Region: PRK13531 585055012474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055012475 Walker A motif; other site 585055012476 ATP binding site [chemical binding]; other site 585055012477 Walker B motif; other site 585055012478 arginine finger; other site 585055012479 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 585055012480 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 585055012481 potassium uptake protein; Region: kup; TIGR00794 585055012482 D-ribose pyranase; Provisional; Region: PRK11797 585055012483 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 585055012484 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055012485 Walker A/P-loop; other site 585055012486 ATP binding site [chemical binding]; other site 585055012487 Q-loop/lid; other site 585055012488 ABC transporter signature motif; other site 585055012489 Walker B; other site 585055012490 D-loop; other site 585055012491 H-loop/switch region; other site 585055012492 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055012493 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055012494 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055012495 TM-ABC transporter signature motif; other site 585055012496 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 585055012497 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 585055012498 ligand binding site [chemical binding]; other site 585055012499 dimerization interface [polypeptide binding]; other site 585055012500 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585055012501 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055012502 substrate binding site [chemical binding]; other site 585055012503 dimer interface [polypeptide binding]; other site 585055012504 ATP binding site [chemical binding]; other site 585055012505 transcriptional repressor RbsR; Provisional; Region: PRK10423 585055012506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055012507 DNA binding site [nucleotide binding] 585055012508 domain linker motif; other site 585055012509 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585055012510 dimerization interface [polypeptide binding]; other site 585055012511 ligand binding site [chemical binding]; other site 585055012512 putative transporter; Provisional; Region: PRK10504 585055012513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012514 putative substrate translocation pore; other site 585055012515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012516 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585055012517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055012518 DNA-binding site [nucleotide binding]; DNA binding site 585055012519 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585055012520 transcriptional regulator HdfR; Provisional; Region: PRK03601 585055012521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055012522 LysR substrate binding domain; Region: LysR_substrate; pfam03466 585055012523 dimerization interface [polypeptide binding]; other site 585055012524 hypothetical protein; Provisional; Region: PRK11027 585055012525 putative ATP-dependent protease; Provisional; Region: PRK09862 585055012526 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585055012527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055012528 Walker A motif; other site 585055012529 ATP binding site [chemical binding]; other site 585055012530 Walker B motif; other site 585055012531 arginine finger; other site 585055012532 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 585055012533 ilvG operon leader peptide; Provisional; Region: PRK10424 585055012534 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 585055012535 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585055012536 PYR/PP interface [polypeptide binding]; other site 585055012537 dimer interface [polypeptide binding]; other site 585055012538 TPP binding site [chemical binding]; other site 585055012539 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585055012540 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585055012541 TPP-binding site [chemical binding]; other site 585055012542 dimer interface [polypeptide binding]; other site 585055012543 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 585055012544 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585055012545 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 585055012546 homodimer interface [polypeptide binding]; other site 585055012547 substrate-cofactor binding pocket; other site 585055012548 catalytic residue [active] 585055012549 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 585055012550 threonine dehydratase; Reviewed; Region: PRK09224 585055012551 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585055012552 tetramer interface [polypeptide binding]; other site 585055012553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055012554 catalytic residue [active] 585055012555 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 585055012556 putative Ile/Val binding site [chemical binding]; other site 585055012557 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 585055012558 putative Ile/Val binding site [chemical binding]; other site 585055012559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055012560 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 585055012561 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 585055012562 putative dimerization interface [polypeptide binding]; other site 585055012563 ketol-acid reductoisomerase; Validated; Region: PRK05225 585055012564 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 585055012565 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585055012566 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585055012567 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 585055012568 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 585055012569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 585055012570 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 585055012571 Part of AAA domain; Region: AAA_19; pfam13245 585055012572 Family description; Region: UvrD_C_2; pfam13538 585055012573 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 585055012574 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585055012575 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 585055012576 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585055012577 ATP binding site [chemical binding]; other site 585055012578 Mg++ binding site [ion binding]; other site 585055012579 motif III; other site 585055012580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055012581 nucleotide binding region [chemical binding]; other site 585055012582 ATP-binding site [chemical binding]; other site 585055012583 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585055012584 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 585055012585 catalytic residues [active] 585055012586 putative rho operon leader peptide; Provisional; Region: PRK09979 585055012587 transcription termination factor Rho; Provisional; Region: rho; PRK09376 585055012588 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 585055012589 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 585055012590 RNA binding site [nucleotide binding]; other site 585055012591 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 585055012592 multimer interface [polypeptide binding]; other site 585055012593 Walker A motif; other site 585055012594 ATP binding site [chemical binding]; other site 585055012595 Walker B motif; other site 585055012596 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 585055012597 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 585055012598 Mg++ binding site [ion binding]; other site 585055012599 putative catalytic motif [active] 585055012600 substrate binding site [chemical binding]; other site 585055012601 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 585055012602 Chain length determinant protein; Region: Wzz; pfam02706 585055012603 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 585055012604 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 585055012605 active site 585055012606 homodimer interface [polypeptide binding]; other site 585055012607 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 585055012608 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585055012609 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585055012610 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585055012611 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 585055012612 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 585055012613 NAD binding site [chemical binding]; other site 585055012614 substrate binding site [chemical binding]; other site 585055012615 homodimer interface [polypeptide binding]; other site 585055012616 active site 585055012617 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 585055012618 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 585055012619 substrate binding site; other site 585055012620 tetramer interface; other site 585055012621 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 585055012622 Coenzyme A binding pocket [chemical binding]; other site 585055012623 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585055012624 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585055012625 inhibitor-cofactor binding pocket; inhibition site 585055012626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055012627 catalytic residue [active] 585055012628 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585055012629 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 585055012630 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 585055012631 putative common antigen polymerase; Provisional; Region: PRK02975 585055012632 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 585055012633 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 585055012634 putative transport protein YifK; Provisional; Region: PRK10746 585055012635 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585055012636 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055012637 FeS/SAM binding site; other site 585055012638 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585055012639 fragment of arylsulfatase-like enzyme (partial);Evidence 7 : Gene remnant; Product type e : enzyme 585055012640 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 585055012641 HemY protein N-terminus; Region: HemY_N; pfam07219 585055012642 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 585055012643 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585055012644 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 585055012645 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 585055012646 active site 585055012647 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 585055012648 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 585055012649 domain interfaces; other site 585055012650 active site 585055012651 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 585055012652 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 585055012653 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 585055012654 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 585055012655 putative iron binding site [ion binding]; other site 585055012656 DKNYY family; Region: DKNYY; pfam13644 585055012657 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 585055012658 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 585055012659 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 585055012660 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585055012661 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585055012662 hypothetical protein; Provisional; Region: PRK10963 585055012663 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 585055012664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585055012665 active site 585055012666 DNA binding site [nucleotide binding] 585055012667 Int/Topo IB signature motif; other site 585055012668 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 585055012669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055012670 motif II; other site 585055012671 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 585055012672 Part of AAA domain; Region: AAA_19; pfam13245 585055012673 Family description; Region: UvrD_C_2; pfam13538 585055012674 Predicted periplasmic protein [Function unknown]; Region: COG3698 585055012675 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 585055012676 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585055012677 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 585055012678 Cl binding site [ion binding]; other site 585055012679 oligomer interface [polypeptide binding]; other site 585055012680 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 585055012681 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 585055012682 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585055012683 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085 585055012684 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 585055012685 EamA-like transporter family; Region: EamA; cl17759 585055012686 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585055012687 CoenzymeA binding site [chemical binding]; other site 585055012688 subunit interaction site [polypeptide binding]; other site 585055012689 PHB binding site; other site 585055012690 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 585055012691 dimerization interface [polypeptide binding]; other site 585055012692 substrate binding site [chemical binding]; other site 585055012693 active site 585055012694 calcium binding site [ion binding]; other site 585055012695 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 585055012696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055012697 ATP binding site [chemical binding]; other site 585055012698 putative Mg++ binding site [ion binding]; other site 585055012699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585055012700 nucleotide binding region [chemical binding]; other site 585055012701 ATP-binding site [chemical binding]; other site 585055012702 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 585055012703 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585055012704 threonine efflux system; Provisional; Region: PRK10229 585055012705 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 585055012706 lysophospholipase L2; Provisional; Region: PRK10749 585055012707 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585055012708 putative hydrolase; Provisional; Region: PRK10976 585055012709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055012710 active site 585055012711 motif I; other site 585055012712 motif II; other site 585055012713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055012714 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585055012715 EamA-like transporter family; Region: EamA; pfam00892 585055012716 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 585055012717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055012718 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 585055012719 putative dimerization interface [polypeptide binding]; other site 585055012720 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 585055012721 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 585055012722 THF binding site; other site 585055012723 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 585055012724 substrate binding site [chemical binding]; other site 585055012725 THF binding site; other site 585055012726 zinc-binding site [ion binding]; other site 585055012727 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585055012728 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 585055012729 uridine phosphorylase; Provisional; Region: PRK11178 585055012730 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 585055012731 DNA recombination protein RmuC; Provisional; Region: PRK10361 585055012732 RmuC family; Region: RmuC; pfam02646 585055012733 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 585055012734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055012735 S-adenosylmethionine binding site [chemical binding]; other site 585055012736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 585055012737 SCP-2 sterol transfer family; Region: SCP2; pfam02036 585055012738 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 585055012739 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 585055012740 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 585055012741 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 585055012742 sec-independent translocase; Provisional; Region: PRK01770 585055012743 sec-independent translocase; Provisional; Region: tatB; PRK00404 585055012744 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 585055012745 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585055012746 active site 585055012747 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 585055012748 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 585055012749 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 585055012750 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 585055012751 FMN reductase; Validated; Region: fre; PRK08051 585055012752 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 585055012753 FAD binding pocket [chemical binding]; other site 585055012754 FAD binding motif [chemical binding]; other site 585055012755 phosphate binding motif [ion binding]; other site 585055012756 beta-alpha-beta structure motif; other site 585055012757 NAD binding pocket [chemical binding]; other site 585055012758 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 585055012759 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585055012760 dimer interface [polypeptide binding]; other site 585055012761 active site 585055012762 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 585055012763 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585055012764 substrate binding site [chemical binding]; other site 585055012765 oxyanion hole (OAH) forming residues; other site 585055012766 trimer interface [polypeptide binding]; other site 585055012767 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585055012768 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585055012769 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585055012770 proline dipeptidase; Provisional; Region: PRK13607 585055012771 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585055012772 active site 585055012773 hypothetical protein; Provisional; Region: PRK11568 585055012774 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 585055012775 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 585055012776 potassium transporter; Provisional; Region: PRK10750 585055012777 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 585055012778 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 585055012779 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 585055012780 Walker A motif; other site 585055012781 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 585055012782 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 585055012783 GTP binding site; other site 585055012784 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 585055012785 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 585055012786 serine/threonine protein kinase; Provisional; Region: PRK11768 585055012787 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 585055012788 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585055012789 catalytic residues [active] 585055012790 hinge region; other site 585055012791 alpha helical domain; other site 585055012792 hypothetical protein; Provisional; Region: PRK11367 585055012793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585055012794 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 585055012795 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 585055012796 putative acyl-acceptor binding pocket; other site 585055012797 DNA polymerase I; Provisional; Region: PRK05755 585055012798 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585055012799 active site 585055012800 metal binding site 1 [ion binding]; metal-binding site 585055012801 putative 5' ssDNA interaction site; other site 585055012802 metal binding site 3; metal-binding site 585055012803 metal binding site 2 [ion binding]; metal-binding site 585055012804 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585055012805 putative DNA binding site [nucleotide binding]; other site 585055012806 putative metal binding site [ion binding]; other site 585055012807 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 585055012808 active site 585055012809 catalytic site [active] 585055012810 substrate binding site [chemical binding]; other site 585055012811 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 585055012812 active site 585055012813 DNA binding site [nucleotide binding] 585055012814 catalytic site [active] 585055012815 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 585055012816 G1 box; other site 585055012817 GTP/Mg2+ binding site [chemical binding]; other site 585055012818 Switch I region; other site 585055012819 G2 box; other site 585055012820 G3 box; other site 585055012821 Switch II region; other site 585055012822 G4 box; other site 585055012823 G5 box; other site 585055012824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 585055012825 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 585055012826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055012827 FeS/SAM binding site; other site 585055012828 HemN C-terminal domain; Region: HemN_C; pfam06969 585055012829 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 585055012830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055012831 active site 585055012832 phosphorylation site [posttranslational modification] 585055012833 intermolecular recognition site; other site 585055012834 dimerization interface [polypeptide binding]; other site 585055012835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055012836 Walker A motif; other site 585055012837 ATP binding site [chemical binding]; other site 585055012838 Walker B motif; other site 585055012839 arginine finger; other site 585055012840 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585055012841 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 585055012842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585055012843 putative active site [active] 585055012844 heme pocket [chemical binding]; other site 585055012845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055012846 dimer interface [polypeptide binding]; other site 585055012847 phosphorylation site [posttranslational modification] 585055012848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055012849 ATP binding site [chemical binding]; other site 585055012850 Mg2+ binding site [ion binding]; other site 585055012851 G-X-G motif; other site 585055012852 glutamine synthetase; Provisional; Region: glnA; PRK09469 585055012853 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 585055012854 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585055012855 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 585055012856 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 585055012857 G1 box; other site 585055012858 putative GEF interaction site [polypeptide binding]; other site 585055012859 GTP/Mg2+ binding site [chemical binding]; other site 585055012860 Switch I region; other site 585055012861 G2 box; other site 585055012862 G3 box; other site 585055012863 Switch II region; other site 585055012864 G4 box; other site 585055012865 G5 box; other site 585055012866 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 585055012867 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 585055012868 transcriptional regulator protein; Region: phnR; TIGR03337 585055012869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055012870 DNA-binding site [nucleotide binding]; DNA binding site 585055012871 UTRA domain; Region: UTRA; pfam07702 585055012872 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585055012873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012874 putative substrate translocation pore; other site 585055012875 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 585055012876 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585055012877 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585055012878 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055012879 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055012880 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 585055012881 substrate binding site [chemical binding]; other site 585055012882 ATP binding site [chemical binding]; other site 585055012883 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 585055012884 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585055012885 Class I aldolases; Region: Aldolase_Class_I; cl17187 585055012886 catalytic residue [active] 585055012887 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585055012888 putative oxidoreductase; Provisional; Region: PRK10083 585055012889 NAD(P) binding site [chemical binding]; other site 585055012890 benzoate transport; Region: 2A0115; TIGR00895 585055012891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055012894 metabolite-proton symporter; Region: 2A0106; TIGR00883 585055012895 putative substrate translocation pore; other site 585055012896 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 585055012897 active site 585055012898 catalytic residues [active] 585055012899 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585055012900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055012901 motif II; other site 585055012902 hypothetical protein; Reviewed; Region: PRK01637 585055012903 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 585055012904 putative active site [active] 585055012905 dimerization interface [polypeptide binding]; other site 585055012906 putative tRNAtyr binding site [nucleotide binding]; other site 585055012907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055012908 Coenzyme A binding pocket [chemical binding]; other site 585055012909 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 585055012910 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 585055012911 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 585055012912 substrate binding pocket [chemical binding]; other site 585055012913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055012914 non-specific DNA binding site [nucleotide binding]; other site 585055012915 salt bridge; other site 585055012916 sequence-specific DNA binding site [nucleotide binding]; other site 585055012917 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 585055012918 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 585055012919 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 585055012920 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 585055012921 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585055012922 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585055012923 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585055012924 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585055012925 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585055012926 [4Fe-4S] binding site [ion binding]; other site 585055012927 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585055012928 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585055012929 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585055012930 molybdopterin cofactor binding site; other site 585055012931 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 585055012932 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 585055012933 putative frv operon regulatory protein; Provisional; Region: PRK09863 585055012934 HTH domain; Region: HTH_11; pfam08279 585055012935 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055012936 active site 585055012937 phosphorylation site [posttranslational modification] 585055012938 putative peptidase; Provisional; Region: PRK09864 585055012939 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 585055012940 oligomer interface [polypeptide binding]; other site 585055012941 active site 585055012942 metal binding site [ion binding]; metal-binding site 585055012943 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 585055012944 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585055012945 active site 585055012946 P-loop; other site 585055012947 phosphorylation site [posttranslational modification] 585055012948 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585055012949 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055012950 active site 585055012951 phosphorylation site [posttranslational modification] 585055012952 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 585055012953 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585055012954 intersubunit interface [polypeptide binding]; other site 585055012955 active site 585055012956 Zn2+ binding site [ion binding]; other site 585055012957 L-rhamnose isomerase; Provisional; Region: PRK01076 585055012958 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 585055012959 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 585055012960 N- and C-terminal domain interface [polypeptide binding]; other site 585055012961 active site 585055012962 putative catalytic site [active] 585055012963 metal binding site [ion binding]; metal-binding site 585055012964 ATP binding site [chemical binding]; other site 585055012965 rhamnulokinase; Provisional; Region: rhaB; PRK10640 585055012966 carbohydrate binding site [chemical binding]; other site 585055012967 transcriptional activator RhaS; Provisional; Region: PRK13503 585055012968 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585055012969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055012970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055012971 transcriptional activator RhaR; Provisional; Region: PRK13500 585055012972 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585055012973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055012974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055012975 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 585055012976 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 585055012977 superoxide dismutase; Provisional; Region: PRK10925 585055012978 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585055012979 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585055012980 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 585055012981 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 585055012982 MOSC domain; Region: MOSC; pfam03473 585055012983 3-alpha domain; Region: 3-alpha; pfam03475 585055012984 two-component sensor protein; Provisional; Region: cpxA; PRK09470 585055012985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055012986 dimerization interface [polypeptide binding]; other site 585055012987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055012988 dimer interface [polypeptide binding]; other site 585055012989 phosphorylation site [posttranslational modification] 585055012990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055012991 ATP binding site [chemical binding]; other site 585055012992 Mg2+ binding site [ion binding]; other site 585055012993 G-X-G motif; other site 585055012994 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 585055012995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055012996 active site 585055012997 intermolecular recognition site; other site 585055012998 dimerization interface [polypeptide binding]; other site 585055012999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055013000 DNA binding site [nucleotide binding] 585055013001 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585055013002 dimer interface [polypeptide binding]; other site 585055013003 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 585055013004 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 585055013005 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 585055013006 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 585055013007 active site 585055013008 ADP/pyrophosphate binding site [chemical binding]; other site 585055013009 dimerization interface [polypeptide binding]; other site 585055013010 allosteric effector site; other site 585055013011 fructose-1,6-bisphosphate binding site; other site 585055013012 sulfate transporter subunit; Provisional; Region: PRK10752 585055013013 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585055013014 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 585055013015 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 585055013016 triosephosphate isomerase; Provisional; Region: PRK14567 585055013017 substrate binding site [chemical binding]; other site 585055013018 dimer interface [polypeptide binding]; other site 585055013019 catalytic triad [active] 585055013020 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 585055013021 Predicted membrane protein [Function unknown]; Region: COG3152 585055013022 hypothetical protein; Provisional; Region: PRK09981 585055013023 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585055013024 Ligand Binding Site [chemical binding]; other site 585055013025 ferredoxin-NADP reductase; Provisional; Region: PRK10926 585055013026 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 585055013027 FAD binding pocket [chemical binding]; other site 585055013028 FAD binding motif [chemical binding]; other site 585055013029 phosphate binding motif [ion binding]; other site 585055013030 beta-alpha-beta structure motif; other site 585055013031 NAD binding pocket [chemical binding]; other site 585055013032 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585055013033 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585055013034 putative active site [active] 585055013035 glycerol kinase; Provisional; Region: glpK; PRK00047 585055013036 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 585055013037 N- and C-terminal domain interface [polypeptide binding]; other site 585055013038 active site 585055013039 MgATP binding site [chemical binding]; other site 585055013040 catalytic site [active] 585055013041 metal binding site [ion binding]; metal-binding site 585055013042 glycerol binding site [chemical binding]; other site 585055013043 homotetramer interface [polypeptide binding]; other site 585055013044 homodimer interface [polypeptide binding]; other site 585055013045 FBP binding site [chemical binding]; other site 585055013046 protein IIAGlc interface [polypeptide binding]; other site 585055013047 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585055013048 amphipathic channel; other site 585055013049 Asn-Pro-Ala signature motifs; other site 585055013050 septal ring assembly protein ZapB; Provisional; Region: PRK15422 585055013051 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 585055013052 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 585055013053 UbiA prenyltransferase family; Region: UbiA; pfam01040 585055013054 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 585055013055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055013056 Walker A motif; other site 585055013057 ATP binding site [chemical binding]; other site 585055013058 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 585055013059 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585055013060 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 585055013061 active site 585055013062 HslU subunit interaction site [polypeptide binding]; other site 585055013063 essential cell division protein FtsN; Provisional; Region: PRK10927 585055013064 cell division protein FtsN; Provisional; Region: PRK12757 585055013065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055013066 DNA binding site [nucleotide binding] 585055013067 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 585055013068 domain linker motif; other site 585055013069 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 585055013070 dimerization interface [polypeptide binding]; other site 585055013071 ligand binding site [chemical binding]; other site 585055013072 primosome assembly protein PriA; Validated; Region: PRK05580 585055013073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055013074 ATP binding site [chemical binding]; other site 585055013075 putative Mg++ binding site [ion binding]; other site 585055013076 helicase superfamily c-terminal domain; Region: HELICc; smart00490 585055013077 ATP-binding site [chemical binding]; other site 585055013078 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 585055013079 PAAR motif; Region: PAAR_motif; cl15808 585055013080 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055013081 RHS Repeat; Region: RHS_repeat; pfam05593 585055013082 RHS Repeat; Region: RHS_repeat; pfam05593 585055013083 RHS Repeat; Region: RHS_repeat; cl11982 585055013084 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585055013085 RHS Repeat; Region: RHS_repeat; pfam05593 585055013086 RHS Repeat; Region: RHS_repeat; pfam05593 585055013087 RHS protein; Region: RHS; pfam03527 585055013088 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585055013089 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 585055013090 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585055013091 fragment of transposase InsB (ORF2) IS1 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013092 fragment of peptidoglycan peptidase (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013093 fragment of peptidoglycan peptidase (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013094 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 585055013095 dimerization interface [polypeptide binding]; other site 585055013096 DNA binding site [nucleotide binding] 585055013097 corepressor binding sites; other site 585055013098 cystathionine gamma-synthase; Provisional; Region: PRK08045 585055013099 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585055013100 homodimer interface [polypeptide binding]; other site 585055013101 substrate-cofactor binding pocket; other site 585055013102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055013103 catalytic residue [active] 585055013104 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 585055013105 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585055013106 putative catalytic residues [active] 585055013107 putative nucleotide binding site [chemical binding]; other site 585055013108 putative aspartate binding site [chemical binding]; other site 585055013109 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 585055013110 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585055013111 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585055013112 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 585055013113 FAD binding site [chemical binding]; other site 585055013114 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 585055013115 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 585055013116 heme binding site [chemical binding]; other site 585055013117 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 585055013118 EamA-like transporter family; Region: EamA; pfam00892 585055013119 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585055013120 EamA-like transporter family; Region: EamA; pfam00892 585055013121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 585055013122 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585055013123 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 585055013124 dimer interface [polypeptide binding]; other site 585055013125 active site 585055013126 metal binding site [ion binding]; metal-binding site 585055013127 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585055013128 active site 585055013129 intersubunit interactions; other site 585055013130 catalytic residue [active] 585055013131 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585055013132 dimerization domain swap beta strand [polypeptide binding]; other site 585055013133 regulatory protein interface [polypeptide binding]; other site 585055013134 active site 585055013135 regulatory phosphorylation site [posttranslational modification]; other site 585055013136 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585055013137 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585055013138 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585055013139 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585055013140 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055013141 active site 585055013142 phosphorylation site [posttranslational modification] 585055013143 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 585055013144 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585055013145 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585055013146 active site 585055013147 P-loop; other site 585055013148 phosphorylation site [posttranslational modification] 585055013149 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 585055013150 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585055013151 dimer interface [polypeptide binding]; other site 585055013152 active site 585055013153 glycine loop; other site 585055013154 pyruvate formate lyase II activase; Provisional; Region: PRK10076 585055013155 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585055013156 active site 585055013157 P-loop; other site 585055013158 phosphorylation site [posttranslational modification] 585055013159 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055013160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055013161 hypothetical protein; Provisional; Region: PRK10649 585055013162 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585055013163 Sulfatase; Region: Sulfatase; pfam00884 585055013164 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 585055013165 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 585055013166 acetylornithine deacetylase; Provisional; Region: PRK05111 585055013167 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 585055013168 metal binding site [ion binding]; metal-binding site 585055013169 putative dimer interface [polypeptide binding]; other site 585055013170 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 585055013171 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585055013172 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 585055013173 nucleotide binding site [chemical binding]; other site 585055013174 N-acetyl-L-glutamate binding site [chemical binding]; other site 585055013175 argininosuccinate lyase; Provisional; Region: PRK04833 585055013176 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 585055013177 active sites [active] 585055013178 tetramer interface [polypeptide binding]; other site 585055013179 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585055013180 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585055013181 putative active site pocket [active] 585055013182 putative metal binding site [ion binding]; other site 585055013183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055013184 D-galactonate transporter; Region: 2A0114; TIGR00893 585055013185 putative substrate translocation pore; other site 585055013186 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 585055013187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055013188 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 585055013189 dimerization interface [polypeptide binding]; other site 585055013190 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 585055013191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585055013192 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585055013193 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 585055013194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055013195 hypothetical protein; Provisional; Region: PRK11056 585055013196 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 585055013197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055013198 S-adenosylmethionine binding site [chemical binding]; other site 585055013199 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 585055013200 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055013201 N-terminal plug; other site 585055013202 ligand-binding site [chemical binding]; other site 585055013203 glutamate racemase; Provisional; Region: PRK00865 585055013204 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 585055013205 FAD binding domain; Region: FAD_binding_4; pfam01565 585055013206 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 585055013207 Biotin operon repressor [Transcription]; Region: BirA; COG1654 585055013208 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 585055013209 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 585055013210 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 585055013211 pantothenate kinase; Provisional; Region: PRK05439 585055013212 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 585055013213 ATP-binding site [chemical binding]; other site 585055013214 CoA-binding site [chemical binding]; other site 585055013215 Mg2+-binding site [ion binding]; other site 585055013216 elongation factor Tu; Reviewed; Region: PRK00049 585055013217 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585055013218 G1 box; other site 585055013219 GEF interaction site [polypeptide binding]; other site 585055013220 GTP/Mg2+ binding site [chemical binding]; other site 585055013221 Switch I region; other site 585055013222 G2 box; other site 585055013223 G3 box; other site 585055013224 Switch II region; other site 585055013225 G4 box; other site 585055013226 G5 box; other site 585055013227 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585055013228 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585055013229 Antibiotic Binding Site [chemical binding]; other site 585055013230 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 585055013231 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 585055013232 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 585055013233 putative homodimer interface [polypeptide binding]; other site 585055013234 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 585055013235 heterodimer interface [polypeptide binding]; other site 585055013236 homodimer interface [polypeptide binding]; other site 585055013237 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 585055013238 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 585055013239 23S rRNA interface [nucleotide binding]; other site 585055013240 L7/L12 interface [polypeptide binding]; other site 585055013241 putative thiostrepton binding site; other site 585055013242 L25 interface [polypeptide binding]; other site 585055013243 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 585055013244 mRNA/rRNA interface [nucleotide binding]; other site 585055013245 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 585055013246 23S rRNA interface [nucleotide binding]; other site 585055013247 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 585055013248 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 585055013249 core dimer interface [polypeptide binding]; other site 585055013250 peripheral dimer interface [polypeptide binding]; other site 585055013251 L10 interface [polypeptide binding]; other site 585055013252 L11 interface [polypeptide binding]; other site 585055013253 putative EF-Tu interaction site [polypeptide binding]; other site 585055013254 putative EF-G interaction site [polypeptide binding]; other site 585055013255 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 585055013256 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 585055013257 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 585055013258 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585055013259 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 585055013260 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585055013261 RPB3 interaction site [polypeptide binding]; other site 585055013262 RPB1 interaction site [polypeptide binding]; other site 585055013263 RPB11 interaction site [polypeptide binding]; other site 585055013264 RPB10 interaction site [polypeptide binding]; other site 585055013265 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 585055013266 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 585055013267 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 585055013268 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 585055013269 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 585055013270 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 585055013271 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585055013272 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 585055013273 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585055013274 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 585055013275 DNA binding site [nucleotide binding] 585055013276 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 585055013277 stationary phase growth adaptation protein; Provisional; Region: PRK09717 585055013278 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 585055013279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055013280 FeS/SAM binding site; other site 585055013281 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 585055013282 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 585055013283 ThiS interaction site; other site 585055013284 putative active site [active] 585055013285 tetramer interface [polypeptide binding]; other site 585055013286 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 585055013287 thiS-thiF/thiG interaction site; other site 585055013288 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585055013289 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 585055013290 ATP binding site [chemical binding]; other site 585055013291 substrate interface [chemical binding]; other site 585055013292 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 585055013293 thiamine phosphate binding site [chemical binding]; other site 585055013294 active site 585055013295 pyrophosphate binding site [ion binding]; other site 585055013296 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 585055013297 ThiC-associated domain; Region: ThiC-associated; pfam13667 585055013298 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 585055013299 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 585055013300 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 585055013301 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 585055013302 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 585055013303 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 585055013304 putative NADH binding site [chemical binding]; other site 585055013305 putative active site [active] 585055013306 nudix motif; other site 585055013307 putative metal binding site [ion binding]; other site 585055013308 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 585055013309 substrate binding site [chemical binding]; other site 585055013310 active site 585055013311 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 585055013312 Active_site [active] 585055013313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 585055013314 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585055013315 IHF dimer interface [polypeptide binding]; other site 585055013316 IHF - DNA interface [nucleotide binding]; other site 585055013317 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 585055013318 zinc resistance protein; Provisional; Region: zraP; PRK11546 585055013319 dimer interface [polypeptide binding]; other site 585055013320 sensor protein ZraS; Provisional; Region: PRK10364 585055013321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055013322 dimer interface [polypeptide binding]; other site 585055013323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055013324 ATP binding site [chemical binding]; other site 585055013325 Mg2+ binding site [ion binding]; other site 585055013326 G-X-G motif; other site 585055013327 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 585055013328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055013329 active site 585055013330 phosphorylation site [posttranslational modification] 585055013331 intermolecular recognition site; other site 585055013332 dimerization interface [polypeptide binding]; other site 585055013333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055013334 Walker A motif; other site 585055013335 ATP binding site [chemical binding]; other site 585055013336 Walker B motif; other site 585055013337 arginine finger; other site 585055013338 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585055013339 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 585055013340 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 585055013341 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 585055013342 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 585055013343 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 585055013344 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 585055013345 purine monophosphate binding site [chemical binding]; other site 585055013346 dimer interface [polypeptide binding]; other site 585055013347 putative catalytic residues [active] 585055013348 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 585055013349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585055013350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055013351 Coenzyme A binding pocket [chemical binding]; other site 585055013352 homoserine O-succinyltransferase; Provisional; Region: PRK05368 585055013353 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 585055013354 proposed active site lysine [active] 585055013355 conserved cys residue [active] 585055013356 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 585055013357 malate synthase A; Region: malate_syn_A; TIGR01344 585055013358 active site 585055013359 isocitrate lyase; Provisional; Region: PRK15063 585055013360 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585055013361 tetramer interface [polypeptide binding]; other site 585055013362 active site 585055013363 Mg2+/Mn2+ binding site [ion binding]; other site 585055013364 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 585055013365 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 585055013366 fragment of regulator of acetyl CoA synthetase (partial);Evidence 7 : Gene remnant; Product type r : regulator 585055013367 transcriptional repressor IclR; Provisional; Region: PRK11569 585055013368 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585055013369 Bacterial transcriptional regulator; Region: IclR; pfam01614 585055013370 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 585055013371 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 585055013372 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 585055013373 substrate binding pocket [chemical binding]; other site 585055013374 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 585055013375 B12 binding site [chemical binding]; other site 585055013376 cobalt ligand [ion binding]; other site 585055013377 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 585055013378 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 585055013379 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585055013380 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585055013381 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 585055013382 active site pocket [active] 585055013383 oxyanion hole [active] 585055013384 catalytic triad [active] 585055013385 active site nucleophile [active] 585055013386 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 585055013387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585055013388 RNA binding surface [nucleotide binding]; other site 585055013389 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 585055013390 probable active site [active] 585055013391 hypothetical protein; Provisional; Region: PRK10515 585055013392 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585055013393 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585055013394 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 585055013395 Zeta toxin; Region: Zeta_toxin; pfam06414 585055013396 aspartate kinase III; Validated; Region: PRK09084 585055013397 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 585055013398 nucleotide binding site [chemical binding]; other site 585055013399 putative catalytic residues [active] 585055013400 aspartate binding site [chemical binding]; other site 585055013401 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 585055013402 lysine allosteric regulatory site; other site 585055013403 dimer interface [polypeptide binding]; other site 585055013404 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 585055013405 dimer interface [polypeptide binding]; other site 585055013406 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 585055013407 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 585055013408 active site 585055013409 dimer interface [polypeptide binding]; other site 585055013410 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 585055013411 dimer interface [polypeptide binding]; other site 585055013412 active site 585055013413 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585055013414 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585055013415 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585055013416 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 585055013417 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 585055013418 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 585055013419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055013420 putative substrate translocation pore; other site 585055013421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055013422 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585055013423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055013424 dimer interface [polypeptide binding]; other site 585055013425 conserved gate region; other site 585055013426 putative PBP binding loops; other site 585055013427 ABC-ATPase subunit interface; other site 585055013428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055013429 dimer interface [polypeptide binding]; other site 585055013430 conserved gate region; other site 585055013431 putative PBP binding loops; other site 585055013432 ABC-ATPase subunit interface; other site 585055013433 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 585055013434 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 585055013435 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585055013436 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 585055013437 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585055013438 Walker A/P-loop; other site 585055013439 ATP binding site [chemical binding]; other site 585055013440 Q-loop/lid; other site 585055013441 ABC transporter signature motif; other site 585055013442 Walker B; other site 585055013443 D-loop; other site 585055013444 H-loop/switch region; other site 585055013445 TOBE domain; Region: TOBE_2; pfam08402 585055013446 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585055013447 trimer interface; other site 585055013448 sugar binding site [chemical binding]; other site 585055013449 maltose regulon periplasmic protein; Provisional; Region: PRK10564 585055013450 hypothetical protein; Validated; Region: PRK09718 585055013451 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 585055013452 SopA-like central domain; Region: SopA; pfam13981 585055013453 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 585055013454 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 585055013455 UbiA prenyltransferase family; Region: UbiA; pfam01040 585055013456 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 585055013457 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 585055013458 putative acyl-acceptor binding pocket; other site 585055013459 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 585055013460 LexA repressor; Validated; Region: PRK00215 585055013461 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585055013462 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585055013463 Catalytic site [active] 585055013464 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 585055013465 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 585055013466 hypothetical protein; Provisional; Region: PRK10428 585055013467 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585055013468 metal binding site 2 [ion binding]; metal-binding site 585055013469 putative DNA binding helix; other site 585055013470 metal binding site 1 [ion binding]; metal-binding site 585055013471 dimer interface [polypeptide binding]; other site 585055013472 structural Zn2+ binding site [ion binding]; other site 585055013473 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 585055013474 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 585055013475 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585055013476 FMN binding site [chemical binding]; other site 585055013477 active site 585055013478 catalytic residues [active] 585055013479 substrate binding site [chemical binding]; other site 585055013480 phage shock protein G; Reviewed; Region: pspG; PRK09459 585055013481 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 585055013482 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 585055013483 NADP binding site [chemical binding]; other site 585055013484 dimer interface [polypeptide binding]; other site 585055013485 replicative DNA helicase; Provisional; Region: PRK08006 585055013486 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585055013487 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585055013488 Walker A motif; other site 585055013489 ATP binding site [chemical binding]; other site 585055013490 Walker B motif; other site 585055013491 DNA binding loops [nucleotide binding] 585055013492 alanine racemase; Reviewed; Region: alr; PRK00053 585055013493 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585055013494 active site 585055013495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585055013496 substrate binding site [chemical binding]; other site 585055013497 catalytic residues [active] 585055013498 dimer interface [polypeptide binding]; other site 585055013499 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585055013500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055013501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055013502 homodimer interface [polypeptide binding]; other site 585055013503 catalytic residue [active] 585055013504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055013505 active site 585055013506 motif I; other site 585055013507 motif II; other site 585055013508 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 585055013509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 585055013510 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 585055013511 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585055013512 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585055013513 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 585055013514 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585055013515 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585055013516 dimer interface [polypeptide binding]; other site 585055013517 ssDNA binding site [nucleotide binding]; other site 585055013518 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585055013519 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 585055013520 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585055013521 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585055013522 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585055013523 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585055013524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055013525 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 585055013526 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 585055013527 DNA binding residues [nucleotide binding] 585055013528 dimer interface [polypeptide binding]; other site 585055013529 [2Fe-2S] cluster binding site [ion binding]; other site 585055013530 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585055013531 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 585055013532 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585055013533 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 585055013534 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585055013535 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 585055013536 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 585055013537 Na binding site [ion binding]; other site 585055013538 Predicted membrane protein [Function unknown]; Region: COG3162 585055013539 acetyl-CoA synthetase; Provisional; Region: PRK00174 585055013540 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 585055013541 active site 585055013542 CoA binding site [chemical binding]; other site 585055013543 acyl-activating enzyme (AAE) consensus motif; other site 585055013544 AMP binding site [chemical binding]; other site 585055013545 acetate binding site [chemical binding]; other site 585055013546 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 585055013547 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 585055013548 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585055013549 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 585055013550 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 585055013551 heme lyase subunit NrfE; Provisional; Region: PRK10369 585055013552 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 585055013553 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585055013554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585055013555 binding surface 585055013556 TPR motif; other site 585055013557 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 585055013558 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585055013559 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585055013560 Sel1-like repeats; Region: SEL1; smart00671 585055013561 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 585055013562 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 585055013563 [4Fe-4S] binding site [ion binding]; other site 585055013564 molybdopterin cofactor binding site; other site 585055013565 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 585055013566 molybdopterin cofactor binding site; other site 585055013567 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 585055013568 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 585055013569 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585055013570 multidrug resistance protein MdtN; Provisional; Region: PRK10476 585055013571 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585055013572 HlyD family secretion protein; Region: HlyD_3; pfam13437 585055013573 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 585055013574 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585055013575 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 585055013576 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 585055013577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055013578 Coenzyme A binding pocket [chemical binding]; other site 585055013579 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 585055013580 AAA domain; Region: AAA_18; pfam13238 585055013581 active site 585055013582 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 585055013583 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585055013584 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 585055013585 active site 585055013586 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 585055013587 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585055013588 Walker A/P-loop; other site 585055013589 ATP binding site [chemical binding]; other site 585055013590 Q-loop/lid; other site 585055013591 ABC transporter signature motif; other site 585055013592 Walker B; other site 585055013593 D-loop; other site 585055013594 H-loop/switch region; other site 585055013595 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 585055013596 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585055013597 Walker A/P-loop; other site 585055013598 ATP binding site [chemical binding]; other site 585055013599 Q-loop/lid; other site 585055013600 ABC transporter signature motif; other site 585055013601 Walker B; other site 585055013602 D-loop; other site 585055013603 H-loop/switch region; other site 585055013604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585055013605 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 585055013606 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 585055013607 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 585055013608 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 585055013609 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 585055013610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055013611 DNA-binding site [nucleotide binding]; DNA binding site 585055013612 UTRA domain; Region: UTRA; pfam07702 585055013613 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 585055013614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585055013615 dimer interface [polypeptide binding]; other site 585055013616 conserved gate region; other site 585055013617 putative PBP binding loops; other site 585055013618 ABC-ATPase subunit interface; other site 585055013619 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 585055013620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585055013621 substrate binding pocket [chemical binding]; other site 585055013622 membrane-bound complex binding site; other site 585055013623 hinge residues; other site 585055013624 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 585055013625 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 585055013626 Walker A/P-loop; other site 585055013627 ATP binding site [chemical binding]; other site 585055013628 Q-loop/lid; other site 585055013629 ABC transporter signature motif; other site 585055013630 Walker B; other site 585055013631 D-loop; other site 585055013632 H-loop/switch region; other site 585055013633 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 585055013634 dimer interface [polypeptide binding]; other site 585055013635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585055013636 hypothetical protein; Provisional; Region: PRK10220 585055013637 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 585055013638 PhnA protein; Region: PhnA; pfam03831 585055013639 hypothetical protein; Provisional; Region: PRK09866 585055013640 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585055013641 G1 box; other site 585055013642 GTP/Mg2+ binding site [chemical binding]; other site 585055013643 G2 box; other site 585055013644 Switch I region; other site 585055013645 G3 box; other site 585055013646 Switch II region; other site 585055013647 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585055013648 G2 box; other site 585055013649 Switch I region; other site 585055013650 G3 box; other site 585055013651 Switch II region; other site 585055013652 G4 box; other site 585055013653 G5 box; other site 585055013654 YjcZ-like protein; Region: YjcZ; pfam13990 585055013655 proline/glycine betaine transporter; Provisional; Region: PRK10642 585055013656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055013657 putative substrate translocation pore; other site 585055013658 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 585055013659 sensor protein BasS/PmrB; Provisional; Region: PRK10755 585055013660 HAMP domain; Region: HAMP; pfam00672 585055013661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055013662 dimer interface [polypeptide binding]; other site 585055013663 phosphorylation site [posttranslational modification] 585055013664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055013665 ATP binding site [chemical binding]; other site 585055013666 Mg2+ binding site [ion binding]; other site 585055013667 G-X-G motif; other site 585055013668 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 585055013669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055013670 active site 585055013671 phosphorylation site [posttranslational modification] 585055013672 intermolecular recognition site; other site 585055013673 dimerization interface [polypeptide binding]; other site 585055013674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055013675 DNA binding site [nucleotide binding] 585055013676 putative metal dependent hydrolase; Provisional; Region: PRK11598 585055013677 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585055013678 Sulfatase; Region: Sulfatase; pfam00884 585055013679 arginine:agmatin antiporter; Provisional; Region: PRK10644 585055013680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585055013681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055013682 arginine decarboxylase; Provisional; Region: PRK15029 585055013683 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585055013684 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585055013685 homodimer interface [polypeptide binding]; other site 585055013686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055013687 catalytic residue [active] 585055013688 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585055013689 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 585055013690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055013691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055013692 alpha-galactosidase; Provisional; Region: PRK15076 585055013693 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 585055013694 NAD binding site [chemical binding]; other site 585055013695 sugar binding site [chemical binding]; other site 585055013696 divalent metal binding site [ion binding]; other site 585055013697 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 585055013698 dimer interface [polypeptide binding]; other site 585055013699 melibiose:sodium symporter; Provisional; Region: PRK10429 585055013700 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 585055013701 hypothetical protein; Provisional; Region: PRK09867 585055013702 fumarate hydratase; Provisional; Region: PRK15389 585055013703 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585055013704 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585055013705 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585055013706 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 585055013707 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 585055013708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055013709 active site 585055013710 phosphorylation site [posttranslational modification] 585055013711 intermolecular recognition site; other site 585055013712 dimerization interface [polypeptide binding]; other site 585055013713 Transcriptional regulator; Region: CitT; pfam12431 585055013714 sensory histidine kinase DcuS; Provisional; Region: PRK11086 585055013715 PAS domain; Region: PAS; smart00091 585055013716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055013717 ATP binding site [chemical binding]; other site 585055013718 Mg2+ binding site [ion binding]; other site 585055013719 G-X-G motif; other site 585055013720 Uncharacterized conserved protein [Function unknown]; Region: COG3592 585055013721 Predicted acetyltransferase [General function prediction only]; Region: COG2388 585055013722 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585055013723 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 585055013724 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 585055013725 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585055013726 dimer interface [polypeptide binding]; other site 585055013727 putative anticodon binding site; other site 585055013728 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585055013729 motif 1; other site 585055013730 active site 585055013731 motif 2; other site 585055013732 motif 3; other site 585055013733 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585055013734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055013735 putative substrate translocation pore; other site 585055013736 POT family; Region: PTR2; pfam00854 585055013737 lysine decarboxylase CadA; Provisional; Region: PRK15400 585055013738 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585055013739 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585055013740 homodimer interface [polypeptide binding]; other site 585055013741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055013742 catalytic residue [active] 585055013743 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585055013744 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 585055013745 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 585055013746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055013747 DNA binding site [nucleotide binding] 585055013748 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585055013749 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585055013750 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585055013751 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585055013752 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585055013753 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585055013754 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585055013755 MPN+ (JAMM) motif; other site 585055013756 Zinc-binding site [ion binding]; other site 585055013757 Antirestriction protein; Region: Antirestrict; pfam03230 585055013758 Transposase; Region: HTH_Tnp_1; cl17663 585055013759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055013760 HTH-like domain; Region: HTH_21; pfam13276 585055013761 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 585055013762 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585055013763 putative active site [active] 585055013764 putative NTP binding site [chemical binding]; other site 585055013765 putative nucleic acid binding site [nucleotide binding]; other site 585055013766 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 585055013767 fragment of transposase ORF B, IS629 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013768 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 585055013769 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055013770 N-terminal plug; other site 585055013771 ligand-binding site [chemical binding]; other site 585055013772 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 585055013773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585055013774 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 585055013775 IucA / IucC family; Region: IucA_IucC; pfam04183 585055013776 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585055013777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 585055013778 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 585055013779 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 585055013780 IucA / IucC family; Region: IucA_IucC; pfam04183 585055013781 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585055013782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055013783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055013784 putative substrate translocation pore; other site 585055013785 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585055013786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055013787 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055013788 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055013789 fragment of transposase ORF B, IS629 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013790 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 585055013791 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585055013792 putative active site [active] 585055013793 putative NTP binding site [chemical binding]; other site 585055013794 putative nucleic acid binding site [nucleotide binding]; other site 585055013795 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 585055013796 HTH-like domain; Region: HTH_21; pfam13276 585055013797 Transposase; Region: HTH_Tnp_1; cl17663 585055013798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055013799 fragment of transposase ORF1, IS66 family (partial);Evidence 7 : Gene remnant 585055013800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585055013801 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585055013802 DNA-binding interface [nucleotide binding]; DNA binding site 585055013803 Integrase core domain; Region: rve; pfam00665 585055013804 fragment of transposase (partial);Evidence 7 : Gene remnant 585055013805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 585055013806 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 585055013807 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585055013808 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055013809 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055013810 fragment of transposase ORF B, IS629 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013811 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 585055013812 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585055013813 putative active site [active] 585055013814 putative NTP binding site [chemical binding]; other site 585055013815 putative nucleic acid binding site [nucleotide binding]; other site 585055013816 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 585055013817 HTH-like domain; Region: HTH_21; pfam13276 585055013818 Transposase; Region: HTH_Tnp_1; cl17663 585055013819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055013820 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 585055013821 fragment of homolog to shiA (SHI-2 pathogenicity island of Shigella flexneri) (part 3);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013822 fragment of homolog to shiA (SHI-2 pathogenicity island of Shigella flexneri) (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013823 fragment of homolog to shiA (SHI-2 pathogenicity island of Shigella flexneri) (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013824 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 585055013825 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055013826 N-terminal plug; other site 585055013827 ligand-binding site [chemical binding]; other site 585055013828 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 585055013829 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585055013830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055013831 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585055013832 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585055013833 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585055013834 Transposase; Region: HTH_Tnp_1; cl17663 585055013835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055013836 HTH-like domain; Region: HTH_21; pfam13276 585055013837 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 585055013838 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585055013839 putative active site [active] 585055013840 putative NTP binding site [chemical binding]; other site 585055013841 putative nucleic acid binding site [nucleotide binding]; other site 585055013842 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 585055013843 fragment of transposase ORF B, IS629 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013844 fragment of transposase ORF2, IS66 family (partial);Evidence 7 : Gene remnant 585055013845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055013846 Transposase; Region: HTH_Tnp_1; pfam01527 585055013847 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585055013848 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585055013849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 585055013850 Transposase; Region: DDE_Tnp_ISL3; pfam01610 585055013851 fragment of transposase ORF 1, IS66 family (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013852 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585055013853 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 585055013854 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585055013855 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585055013856 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585055013857 fragment of plasmid transfer protein (partial);Evidence 7 : Gene remnant 585055013858 fragment of transposase (partial);Evidence 7 : Gene remnant 585055013859 fragment of transposase, IS110 family (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055013860 Part of AAA domain; Region: AAA_19; pfam13245 585055013861 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 585055013862 AAA domain; Region: AAA_12; pfam13087 585055013863 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 585055013864 putative active site [active] 585055013865 catalytic site [active] 585055013866 integrase; Provisional; Region: PRK09692 585055013867 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585055013868 active site 585055013869 Int/Topo IB signature motif; other site 585055013870 putative transcriptional regulator; Provisional; Region: PRK11640 585055013871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055013872 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 585055013873 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 585055013874 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 585055013875 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 585055013876 DsbD alpha interface [polypeptide binding]; other site 585055013877 catalytic residues [active] 585055013878 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 585055013879 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585055013880 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 585055013881 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 585055013882 Aspartase; Region: Aspartase; cd01357 585055013883 active sites [active] 585055013884 tetramer interface [polypeptide binding]; other site 585055013885 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 585055013886 putative transporter; Provisional; Region: PRK11021 585055013887 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 585055013888 oligomerisation interface [polypeptide binding]; other site 585055013889 mobile loop; other site 585055013890 roof hairpin; other site 585055013891 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 585055013892 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 585055013893 ring oligomerisation interface [polypeptide binding]; other site 585055013894 ATP/Mg binding site [chemical binding]; other site 585055013895 stacking interactions; other site 585055013896 hinge regions; other site 585055013897 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 585055013898 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 585055013899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055013900 FeS/SAM binding site; other site 585055013901 elongation factor P; Validated; Region: PRK00529 585055013902 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585055013903 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585055013904 RNA binding site [nucleotide binding]; other site 585055013905 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585055013906 RNA binding site [nucleotide binding]; other site 585055013907 entericidin A; Provisional; Region: PRK09810 585055013908 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 585055013909 multidrug efflux system protein; Provisional; Region: PRK11431 585055013910 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 585055013911 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 585055013912 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 585055013913 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585055013914 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 585055013915 Iron-sulfur protein interface; other site 585055013916 proximal quinone binding site [chemical binding]; other site 585055013917 C-subunit interface; other site 585055013918 distal quinone binding site; other site 585055013919 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 585055013920 D-subunit interface [polypeptide binding]; other site 585055013921 Iron-sulfur protein interface; other site 585055013922 proximal quinone binding site [chemical binding]; other site 585055013923 distal quinone binding site [chemical binding]; other site 585055013924 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 585055013925 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585055013926 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 585055013927 L-aspartate oxidase; Provisional; Region: PRK06175 585055013928 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585055013929 poxB regulator PoxA; Provisional; Region: PRK09350 585055013930 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585055013931 motif 1; other site 585055013932 dimer interface [polypeptide binding]; other site 585055013933 active site 585055013934 motif 2; other site 585055013935 motif 3; other site 585055013936 inner membrane transporter YjeM; Provisional; Region: PRK15238 585055013937 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 585055013938 putative mechanosensitive channel protein; Provisional; Region: PRK10929 585055013939 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 585055013940 DNA-binding site [nucleotide binding]; DNA binding site 585055013941 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585055013942 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585055013943 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 585055013944 GTPase RsgA; Reviewed; Region: PRK12288 585055013945 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585055013946 RNA binding site [nucleotide binding]; other site 585055013947 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 585055013948 GTPase/Zn-binding domain interface [polypeptide binding]; other site 585055013949 GTP/Mg2+ binding site [chemical binding]; other site 585055013950 G4 box; other site 585055013951 G5 box; other site 585055013952 G1 box; other site 585055013953 Switch I region; other site 585055013954 G2 box; other site 585055013955 G3 box; other site 585055013956 Switch II region; other site 585055013957 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 585055013958 catalytic site [active] 585055013959 putative active site [active] 585055013960 putative substrate binding site [chemical binding]; other site 585055013961 dimer interface [polypeptide binding]; other site 585055013962 epoxyqueuosine reductase; Region: TIGR00276 585055013963 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 585055013964 putative carbohydrate kinase; Provisional; Region: PRK10565 585055013965 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 585055013966 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 585055013967 putative substrate binding site [chemical binding]; other site 585055013968 putative ATP binding site [chemical binding]; other site 585055013969 ADP-binding protein; Provisional; Region: PRK10646 585055013970 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 585055013971 AMIN domain; Region: AMIN; pfam11741 585055013972 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585055013973 active site 585055013974 metal binding site [ion binding]; metal-binding site 585055013975 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 585055013976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055013977 ATP binding site [chemical binding]; other site 585055013978 Mg2+ binding site [ion binding]; other site 585055013979 G-X-G motif; other site 585055013980 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 585055013981 ATP binding site [chemical binding]; other site 585055013982 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 585055013983 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 585055013984 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 585055013985 bacterial Hfq-like; Region: Hfq; cd01716 585055013986 hexamer interface [polypeptide binding]; other site 585055013987 Sm1 motif; other site 585055013988 RNA binding site [nucleotide binding]; other site 585055013989 Sm2 motif; other site 585055013990 GTPase HflX; Provisional; Region: PRK11058 585055013991 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 585055013992 HflX GTPase family; Region: HflX; cd01878 585055013993 G1 box; other site 585055013994 GTP/Mg2+ binding site [chemical binding]; other site 585055013995 Switch I region; other site 585055013996 G2 box; other site 585055013997 G3 box; other site 585055013998 Switch II region; other site 585055013999 G4 box; other site 585055014000 G5 box; other site 585055014001 FtsH protease regulator HflK; Provisional; Region: PRK10930 585055014002 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 585055014003 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 585055014004 FtsH protease regulator HflC; Provisional; Region: PRK11029 585055014005 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 585055014006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 585055014007 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 585055014008 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 585055014009 GDP-binding site [chemical binding]; other site 585055014010 ACT binding site; other site 585055014011 IMP binding site; other site 585055014012 Predicted transcriptional regulator [Transcription]; Region: COG1959 585055014013 transcriptional repressor NsrR; Provisional; Region: PRK11014 585055014014 exoribonuclease R; Provisional; Region: PRK11642 585055014015 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 585055014016 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585055014017 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585055014018 RNB domain; Region: RNB; pfam00773 585055014019 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 585055014020 RNA binding site [nucleotide binding]; other site 585055014021 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 585055014022 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 585055014023 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585055014024 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 585055014025 PspA/IM30 family; Region: PspA_IM30; pfam04012 585055014026 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 585055014027 Predicted membrane protein [Function unknown]; Region: COG3766 585055014028 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585055014029 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585055014030 Predicted integral membrane protein [Function unknown]; Region: COG5463 585055014031 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585055014032 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 585055014033 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 585055014034 FAD binding site [chemical binding]; other site 585055014035 substrate binding site [chemical binding]; other site 585055014036 catalytic residues [active] 585055014037 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055014038 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 585055014039 esterase; Provisional; Region: PRK10566 585055014040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585055014041 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585055014042 transcriptional repressor UlaR; Provisional; Region: PRK13509 585055014043 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585055014044 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055014045 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 585055014046 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 585055014047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 585055014048 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 585055014049 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 585055014050 active site 585055014051 P-loop; other site 585055014052 phosphorylation site [posttranslational modification] 585055014053 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055014054 active site 585055014055 phosphorylation site [posttranslational modification] 585055014056 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585055014057 active site 585055014058 dimer interface [polypeptide binding]; other site 585055014059 magnesium binding site [ion binding]; other site 585055014060 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 585055014061 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585055014062 AP (apurinic/apyrimidinic) site pocket; other site 585055014063 DNA interaction; other site 585055014064 Metal-binding active site; metal-binding site 585055014065 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585055014066 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585055014067 intersubunit interface [polypeptide binding]; other site 585055014068 active site 585055014069 Zn2+ binding site [ion binding]; other site 585055014070 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 585055014071 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585055014072 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 585055014073 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585055014074 dimer interface [polypeptide binding]; other site 585055014075 ssDNA binding site [nucleotide binding]; other site 585055014076 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585055014077 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 585055014078 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 585055014079 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 585055014080 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 585055014081 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 585055014082 Transposase IS200 like; Region: Y1_Tnp; pfam01797 585055014083 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585055014084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 585055014085 Probable transposase; Region: OrfB_IS605; pfam01385 585055014086 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585055014087 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 585055014088 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 585055014089 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 585055014090 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585055014091 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585055014092 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 585055014093 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 585055014094 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 585055014095 Hemerythrin-like domain; Region: Hr-like; cd12108 585055014096 Fe binding site [ion binding]; other site 585055014097 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585055014098 EamA-like transporter family; Region: EamA; pfam00892 585055014099 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585055014100 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 585055014101 NADP binding site [chemical binding]; other site 585055014102 Predicted transcriptional regulators [Transcription]; Region: COG1733 585055014103 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 585055014104 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 585055014105 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 585055014106 active site 585055014107 metal binding site [ion binding]; metal-binding site 585055014108 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585055014109 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 585055014110 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585055014111 active site 585055014112 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 585055014113 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 585055014114 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585055014115 Domain of unknown function DUF21; Region: DUF21; pfam01595 585055014116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585055014117 Transporter associated domain; Region: CorC_HlyC; smart01091 585055014118 methionine sulfoxide reductase A; Provisional; Region: PRK00058 585055014119 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 585055014120 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585055014121 Surface antigen; Region: Bac_surface_Ag; pfam01103 585055014122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 585055014123 Family of unknown function (DUF490); Region: DUF490; pfam04357 585055014124 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585055014125 putative active site pocket [active] 585055014126 dimerization interface [polypeptide binding]; other site 585055014127 putative catalytic residue [active] 585055014128 antitoxin ChpS; Provisional; Region: PRK11347 585055014129 toxin ChpB; Provisional; Region: PRK09812 585055014130 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 585055014131 dimer interface [polypeptide binding]; other site 585055014132 substrate binding site [chemical binding]; other site 585055014133 metal binding sites [ion binding]; metal-binding site 585055014134 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 585055014135 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585055014136 putative ligand binding site [chemical binding]; other site 585055014137 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585055014138 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585055014139 Walker A/P-loop; other site 585055014140 ATP binding site [chemical binding]; other site 585055014141 Q-loop/lid; other site 585055014142 ABC transporter signature motif; other site 585055014143 Walker B; other site 585055014144 D-loop; other site 585055014145 H-loop/switch region; other site 585055014146 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585055014147 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055014148 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055014149 TM-ABC transporter signature motif; other site 585055014150 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585055014151 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585055014152 TM-ABC transporter signature motif; other site 585055014153 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 585055014154 AMP binding site [chemical binding]; other site 585055014155 metal binding site [ion binding]; metal-binding site 585055014156 active site 585055014157 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 585055014158 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585055014159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585055014160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585055014161 hypothetical protein; Provisional; Region: PRK05255 585055014162 peptidase PmbA; Provisional; Region: PRK11040 585055014163 cytochrome b562; Provisional; Region: PRK15058 585055014164 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 585055014165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055014166 FeS/SAM binding site; other site 585055014167 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 585055014168 ATP cone domain; Region: ATP-cone; pfam03477 585055014169 Class III ribonucleotide reductase; Region: RNR_III; cd01675 585055014170 effector binding site; other site 585055014171 active site 585055014172 Zn binding site [ion binding]; other site 585055014173 glycine loop; other site 585055014174 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 585055014175 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 585055014176 Ca binding site [ion binding]; other site 585055014177 active site 585055014178 catalytic site [active] 585055014179 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 585055014180 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055014181 active site turn [active] 585055014182 phosphorylation site [posttranslational modification] 585055014183 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585055014184 trehalose repressor; Provisional; Region: treR; PRK09492 585055014185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055014186 DNA binding site [nucleotide binding] 585055014187 domain linker motif; other site 585055014188 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 585055014189 dimerization interface [polypeptide binding]; other site 585055014190 ligand binding site [chemical binding]; other site 585055014191 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 585055014192 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 585055014193 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585055014194 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 585055014195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055014196 motif II; other site 585055014197 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 585055014198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585055014199 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585055014200 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055014201 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585055014202 homotrimer interaction site [polypeptide binding]; other site 585055014203 putative active site [active] 585055014204 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 585055014205 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 585055014206 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 585055014207 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 585055014208 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585055014209 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585055014210 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 585055014211 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 585055014212 homotrimer interaction site [polypeptide binding]; other site 585055014213 putative active site [active] 585055014214 oxidoreductase; Provisional; Region: PRK12742 585055014215 classical (c) SDRs; Region: SDR_c; cd05233 585055014216 NAD(P) binding site [chemical binding]; other site 585055014217 active site 585055014218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585055014219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055014220 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 585055014221 fragment of conserved hypothetical protein (part 1);Evidence 7 : Gene remnant 585055014222 fragment of conserved hypothetical protein (part 2);Evidence 7 : Gene remnant 585055014223 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 585055014224 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585055014225 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585055014226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 585055014227 RNase E inhibitor protein; Provisional; Region: PRK11191 585055014228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585055014229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055014230 Coenzyme A binding pocket [chemical binding]; other site 585055014231 Predicted membrane protein [Function unknown]; Region: COG4269 585055014232 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 585055014233 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585055014234 HIGH motif; other site 585055014235 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585055014236 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585055014237 active site 585055014238 KMSKS motif; other site 585055014239 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 585055014240 tRNA binding surface [nucleotide binding]; other site 585055014241 anticodon binding site; other site 585055014242 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 585055014243 DNA polymerase III subunit chi; Validated; Region: PRK05728 585055014244 multifunctional aminopeptidase A; Provisional; Region: PRK00913 585055014245 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585055014246 interface (dimer of trimers) [polypeptide binding]; other site 585055014247 Substrate-binding/catalytic site; other site 585055014248 Zn-binding sites [ion binding]; other site 585055014249 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 585055014250 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585055014251 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 585055014252 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585055014253 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 585055014254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585055014255 Walker A motif; other site 585055014256 ATP binding site [chemical binding]; other site 585055014257 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 585055014258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055014259 DNA binding site [nucleotide binding] 585055014260 domain linker motif; other site 585055014261 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585055014262 putative dimerization interface [polypeptide binding]; other site 585055014263 putative ligand binding site [chemical binding]; other site 585055014264 fructuronate transporter; Provisional; Region: PRK10034; cl15264 585055014265 gluconate transporter; Region: gntP; TIGR00791 585055014266 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 585055014267 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585055014268 NADP binding site [chemical binding]; other site 585055014269 homodimer interface [polypeptide binding]; other site 585055014270 active site 585055014271 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 585055014272 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 585055014273 putative NAD(P) binding site [chemical binding]; other site 585055014274 catalytic Zn binding site [ion binding]; other site 585055014275 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 585055014276 ATP-binding site [chemical binding]; other site 585055014277 Gluconate-6-phosphate binding site [chemical binding]; other site 585055014278 Shikimate kinase; Region: SKI; pfam01202 585055014279 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585055014280 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585055014281 putative NAD(P) binding site [chemical binding]; other site 585055014282 putative substrate binding site [chemical binding]; other site 585055014283 catalytic Zn binding site [ion binding]; other site 585055014284 structural Zn binding site [ion binding]; other site 585055014285 dimer interface [polypeptide binding]; other site 585055014286 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585055014287 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585055014288 active site 585055014289 Int/Topo IB signature motif; other site 585055014290 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585055014291 Sulfatase; Region: Sulfatase; cl17466 585055014292 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 585055014293 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 585055014294 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 585055014295 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 585055014296 AAA-like domain; Region: AAA_10; pfam12846 585055014297 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 585055014298 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 585055014299 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 585055014300 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 585055014301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055014302 Walker A/P-loop; other site 585055014303 ATP binding site [chemical binding]; other site 585055014304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055014305 ABC transporter signature motif; other site 585055014306 Walker B; other site 585055014307 D-loop; other site 585055014308 H-loop/switch region; other site 585055014309 hypothetical protein; Provisional; Region: PRK06850 585055014310 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585055014311 Active Sites [active] 585055014312 DNA-sulfur modification-associated; Region: DndB; pfam14072 585055014313 DGQHR domain; Region: DGQHR; TIGR03187 585055014314 ProQ/FINO family; Region: ProQ; pfam04352 585055014315 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585055014316 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585055014317 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055014318 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 585055014319 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055014320 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 585055014321 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 585055014322 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585055014323 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585055014324 dimerization interface [polypeptide binding]; other site 585055014325 putative DNA binding site [nucleotide binding]; other site 585055014326 putative Zn2+ binding site [ion binding]; other site 585055014327 tetracycline repressor protein TetR; Provisional; Region: PRK13756 585055014328 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055014329 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 585055014330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055014331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055014332 putative substrate translocation pore; other site 585055014333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585055014334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055014335 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585055014336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055014337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055014338 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585055014339 Helix-turn-helix domain; Region: HTH_28; pfam13518 585055014340 Winged helix-turn helix; Region: HTH_29; pfam13551 585055014341 Homeodomain-like domain; Region: HTH_32; pfam13565 585055014342 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585055014343 Transposase; Region: HTH_Tnp_1; cl17663 585055014344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055014345 putative transposase OrfB; Reviewed; Region: PHA02517 585055014346 HTH-like domain; Region: HTH_21; pfam13276 585055014347 Integrase core domain; Region: rve; pfam00665 585055014348 Integrase core domain; Region: rve_2; pfam13333 585055014349 pyrrolysine biosynthesis radical SAM protein; Region: pyrrolys_PylB; TIGR03910 585055014350 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 585055014351 active site 585055014352 NTP binding site [chemical binding]; other site 585055014353 metal binding triad [ion binding]; metal-binding site 585055014354 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 585055014355 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 585055014356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585055014357 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585055014358 DNA-binding interface [nucleotide binding]; DNA binding site 585055014359 Integrase core domain; Region: rve; pfam00665 585055014360 transposase/IS protein; Provisional; Region: PRK09183 585055014361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055014362 Walker A motif; other site 585055014363 ATP binding site [chemical binding]; other site 585055014364 Walker B motif; other site 585055014365 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585055014366 Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673 585055014367 Predicted GTPase [General function prediction only]; Region: COG3596 585055014368 YfjP GTPase; Region: YfjP; cd11383 585055014369 G1 box; other site 585055014370 GTP/Mg2+ binding site [chemical binding]; other site 585055014371 Switch I region; other site 585055014372 G2 box; other site 585055014373 Switch II region; other site 585055014374 G3 box; other site 585055014375 G4 box; other site 585055014376 G5 box; other site 585055014377 HTH domain; Region: HTH_11; cl17392 585055014378 WYL domain; Region: WYL; pfam13280 585055014379 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585055014380 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585055014381 Antirestriction protein; Region: Antirestrict; pfam03230 585055014382 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585055014383 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585055014384 MPN+ (JAMM) motif; other site 585055014385 Zinc-binding site [ion binding]; other site 585055014386 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585055014387 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585055014388 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585055014389 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585055014390 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 585055014391 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 585055014392 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 585055014393 active site 585055014394 catalytic residues [active] 585055014395 DNA binding site [nucleotide binding] 585055014396 Int/Topo IB signature motif; other site 585055014397 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 585055014398 Putative helicase; Region: TraI_2; pfam07514 585055014399 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 585055014400 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 585055014401 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 585055014402 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 585055014403 HNH endonuclease; Region: HNH_2; pfam13391 585055014404 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055014405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055014406 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055014407 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055014408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055014409 salt bridge; other site 585055014410 non-specific DNA binding site [nucleotide binding]; other site 585055014411 sequence-specific DNA binding site [nucleotide binding]; other site 585055014412 Fic family protein [Function unknown]; Region: COG3177 585055014413 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 585055014414 Fic/DOC family; Region: Fic; pfam02661 585055014415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055014416 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055014417 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055014418 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585055014419 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 585055014420 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585055014421 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585055014422 putative active site [active] 585055014423 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 585055014424 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585055014425 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585055014426 active site turn [active] 585055014427 phosphorylation site [posttranslational modification] 585055014428 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 585055014429 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 585055014430 putative active site cavity [active] 585055014431 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 585055014432 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585055014433 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585055014434 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585055014435 DNA binding site [nucleotide binding] 585055014436 domain linker motif; other site 585055014437 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585055014438 putative dimerization interface [polypeptide binding]; other site 585055014439 putative ligand binding site [chemical binding]; other site 585055014440 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585055014441 active site 585055014442 phosphorylation site [posttranslational modification] 585055014443 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 585055014444 active site 585055014445 P-loop; other site 585055014446 phosphorylation site [posttranslational modification] 585055014447 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 585055014448 Transposase; Region: HTH_Tnp_1; pfam01527 585055014449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055014450 fragment of IS2 insertion element repressor InsA; KpLE2 phage-like element (partial);Evidence 7 : Gene remnant; Product type r : regulator 585055014451 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 585055014452 active site 585055014453 catalytic residues [active] 585055014454 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 585055014455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055014456 putative substrate translocation pore; other site 585055014457 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585055014458 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585055014459 substrate binding site [chemical binding]; other site 585055014460 dimer interface [polypeptide binding]; other site 585055014461 ATP binding site [chemical binding]; other site 585055014462 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 585055014463 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 585055014464 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585055014465 fragment of acetolactate synthase I, small subunit (part 2);Evidence 7 : Gene remnant; Product type e : enzyme 585055014466 fragment of acetolactate synthase I, small subunit (part 1);Evidence 7 : Gene remnant; Product type e : enzyme 585055014467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055014468 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585055014469 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585055014470 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585055014471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055014472 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585055014473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055014474 Transposase; Region: HTH_Tnp_1; pfam01527 585055014475 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585055014476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585055014477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585055014478 Predicted membrane protein [Function unknown]; Region: COG4325 585055014479 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 585055014480 BCCT family transporter; Region: BCCT; cl00569 585055014481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055014482 Transposase; Region: HTH_Tnp_1; pfam01527 585055014483 putative transposase OrfB; Reviewed; Region: PHA02517 585055014484 Integrase core domain; Region: rve; pfam00665 585055014485 Integrase core domain; Region: rve_3; pfam13683 585055014486 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585055014487 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585055014488 putative acyl-acceptor binding pocket; other site 585055014489 Protein of unknown function (DUF535); Region: DUF535; pfam04393 585055014490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585055014491 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585055014492 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 585055014493 putative active site [active] 585055014494 putative metal binding site [ion binding]; other site 585055014495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055014496 Transposase; Region: HTH_Tnp_1; cl17663 585055014497 fragment of transposase ORF B (fragment), IS911 (part 1);Evidence 7 : Gene remnant; Product type pe : enzyme 585055014498 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 585055014499 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585055014500 putative active site [active] 585055014501 putative NTP binding site [chemical binding]; other site 585055014502 putative nucleic acid binding site [nucleotide binding]; other site 585055014503 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 585055014504 fragment of transposase ORF B (fragment), IS911 (part 2);Evidence 7 : Gene remnant; Product type pe : enzyme 585055014505 fragment of transposase ORF B, IS911 (partial);Evidence 7 : Gene remnant; Product type pe : enzyme 585055014506 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 585055014507 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 585055014508 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585055014509 Walker A/P-loop; other site 585055014510 ATP binding site [chemical binding]; other site 585055014511 Q-loop/lid; other site 585055014512 ABC transporter signature motif; other site 585055014513 Walker B; other site 585055014514 D-loop; other site 585055014515 H-loop/switch region; other site 585055014516 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585055014517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055014518 ABC-ATPase subunit interface; other site 585055014519 dimer interface [polypeptide binding]; other site 585055014520 putative PBP binding regions; other site 585055014521 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585055014522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585055014523 dimer interface [polypeptide binding]; other site 585055014524 ABC-ATPase subunit interface; other site 585055014525 putative PBP binding regions; other site 585055014526 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 585055014527 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585055014528 siderophore binding site; other site 585055014529 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 585055014530 Secretin and TonB N terminus short domain; Region: STN; smart00965 585055014531 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585055014532 N-terminal plug; other site 585055014533 ligand-binding site [chemical binding]; other site 585055014534 fec operon regulator FecR; Reviewed; Region: PRK09774 585055014535 FecR protein; Region: FecR; pfam04773 585055014536 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 585055014537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585055014538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585055014539 DNA binding residues [nucleotide binding] 585055014540 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 585055014541 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 585055014542 homodimer interface [polypeptide binding]; other site 585055014543 putative GKAP docking site [polypeptide binding]; other site 585055014544 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585055014545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055014546 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585055014547 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585055014548 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585055014549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585055014550 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585055014551 Transposase; Region: HTH_Tnp_1; pfam01527 585055014552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585055014553 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585055014554 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585055014555 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585055014556 Haemolysin expression modulating protein; Region: HHA; pfam05321 585055014557 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 585055014558 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585055014559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585055014560 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585055014561 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585055014562 fragment of minor component of type 1 fimbriae (partial);Evidence 7 : Gene remnant; Product type s : structure 585055014563 fructuronate transporter; Provisional; Region: PRK10034 585055014564 gluconate transporter; Region: gntP; TIGR00791 585055014565 mannonate dehydratase; Region: uxuA; TIGR00695 585055014566 mannonate dehydratase; Provisional; Region: PRK03906 585055014567 D-mannonate oxidoreductase; Provisional; Region: PRK15037 585055014568 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585055014569 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585055014570 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 585055014571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055014572 DNA-binding site [nucleotide binding]; DNA binding site 585055014573 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585055014574 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 585055014575 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 585055014576 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 585055014577 cell density-dependent motility repressor; Provisional; Region: PRK10082 585055014578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585055014579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585055014580 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 585055014581 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 585055014582 dimer interface [polypeptide binding]; other site 585055014583 active site 585055014584 hypothetical protein; Provisional; Region: PRK10519 585055014585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 585055014586 Nucleoside recognition; Region: Gate; pfam07670 585055014587 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 585055014588 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 585055014589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585055014590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055014591 putative substrate translocation pore; other site 585055014592 SdiA-regulated; Region: SdiA-regulated; pfam06977 585055014593 SdiA-regulated; Region: SdiA-regulated; cd09971 585055014594 putative active site [active] 585055014595 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 585055014596 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 585055014597 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 585055014598 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 585055014599 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 585055014600 Predicted membrane protein [Function unknown]; Region: COG2733 585055014601 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 585055014602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055014603 putative substrate translocation pore; other site 585055014604 putative transposase; Provisional; Region: PRK09857 585055014605 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585055014606 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585055014607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055014608 DNA-binding site [nucleotide binding]; DNA binding site 585055014609 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585055014610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585055014611 homodimer interface [polypeptide binding]; other site 585055014612 catalytic residue [active] 585055014613 fragment of conserved hypothetical protein (part 1);Evidence 7 : Gene remnant 585055014614 fragment of conserved hypothetical protein (part 2);Evidence 7 : Gene remnant 585055014615 endoribonuclease SymE; Provisional; Region: PRK13605 585055014616 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 585055014617 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 585055014618 HsdM N-terminal domain; Region: HsdM_N; pfam12161 585055014619 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 585055014620 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585055014621 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 585055014622 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 585055014623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585055014624 ATP binding site [chemical binding]; other site 585055014625 putative Mg++ binding site [ion binding]; other site 585055014626 Uncharacterized conserved protein [Function unknown]; Region: COG1479 585055014627 Protein of unknown function DUF262; Region: DUF262; pfam03235 585055014628 Protein of unknown function DUF262; Region: DUF262; pfam03235 585055014629 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 585055014630 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 585055014631 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 585055014632 P-loop, Walker A motif; other site 585055014633 Base recognition motif; other site 585055014634 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 585055014635 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 585055014636 Uncharacterized small protein [Function unknown]; Region: COG2879 585055014637 carbon starvation protein A; Provisional; Region: PRK15015 585055014638 Carbon starvation protein CstA; Region: CstA; pfam02554 585055014639 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585055014640 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 585055014641 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585055014642 dimer interface [polypeptide binding]; other site 585055014643 ligand binding site [chemical binding]; other site 585055014644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055014645 dimerization interface [polypeptide binding]; other site 585055014646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585055014647 dimer interface [polypeptide binding]; other site 585055014648 putative CheW interface [polypeptide binding]; other site 585055014649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585055014650 D-galactonate transporter; Region: 2A0114; TIGR00893 585055014651 putative substrate translocation pore; other site 585055014652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585055014653 DNA-binding site [nucleotide binding]; DNA binding site 585055014654 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585055014655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 585055014656 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585055014657 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585055014658 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585055014659 putative NAD(P) binding site [chemical binding]; other site 585055014660 catalytic Zn binding site [ion binding]; other site 585055014661 structural Zn binding site [ion binding]; other site 585055014662 phosphoglycerol transferase I; Provisional; Region: PRK03776 585055014663 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 585055014664 hypothetical protein; Provisional; Region: PRK11667 585055014665 DNA replication protein DnaC; Validated; Region: PRK07952 585055014666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585055014667 Walker A motif; other site 585055014668 ATP binding site [chemical binding]; other site 585055014669 Walker B motif; other site 585055014670 primosomal protein DnaI; Provisional; Region: PRK02854 585055014671 hypothetical protein; Provisional; Region: PRK09917 585055014672 Uncharacterized conserved protein [Function unknown]; Region: COG2966 585055014673 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 585055014674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585055014675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055014676 DNA binding residues [nucleotide binding] 585055014677 dimerization interface [polypeptide binding]; other site 585055014678 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 585055014679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585055014680 DNA binding residues [nucleotide binding] 585055014681 dimerization interface [polypeptide binding]; other site 585055014682 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 585055014683 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585055014684 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 585055014685 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 585055014686 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 585055014687 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 585055014688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585055014689 S-adenosylmethionine binding site [chemical binding]; other site 585055014690 DNA polymerase III subunit psi; Validated; Region: PRK06856 585055014691 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 585055014692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585055014693 Coenzyme A binding pocket [chemical binding]; other site 585055014694 dUMP phosphatase; Provisional; Region: PRK09449 585055014695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055014696 motif II; other site 585055014697 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 585055014698 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 585055014699 G1 box; other site 585055014700 putative GEF interaction site [polypeptide binding]; other site 585055014701 GTP/Mg2+ binding site [chemical binding]; other site 585055014702 Switch I region; other site 585055014703 G2 box; other site 585055014704 G3 box; other site 585055014705 Switch II region; other site 585055014706 G4 box; other site 585055014707 G5 box; other site 585055014708 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 585055014709 periplasmic protein; Provisional; Region: PRK10568 585055014710 BON domain; Region: BON; pfam04972 585055014711 BON domain; Region: BON; pfam04972 585055014712 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 585055014713 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 585055014714 active site 585055014715 nucleophile elbow; other site 585055014716 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585055014717 active site 585055014718 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 585055014719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585055014720 FeS/SAM binding site; other site 585055014721 hypothetical protein; Provisional; Region: PRK10977 585055014722 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 585055014723 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 585055014724 intersubunit interface [polypeptide binding]; other site 585055014725 active site 585055014726 catalytic residue [active] 585055014727 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 585055014728 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585055014729 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585055014730 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 585055014731 phosphopentomutase; Provisional; Region: PRK05362 585055014732 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 585055014733 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 585055014734 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 585055014735 fragment of transcriptionnal regulator (partial);Evidence 7 : Gene remnant 585055014736 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 585055014737 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 585055014738 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 585055014739 hypothetical protein; Provisional; Region: PRK11246 585055014740 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 585055014741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585055014742 motif II; other site 585055014743 DNA repair protein RadA; Region: sms; TIGR00416 585055014744 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 585055014745 Walker A motif/ATP binding site; other site 585055014746 ATP binding site [chemical binding]; other site 585055014747 Walker B motif; other site 585055014748 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585055014749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585055014750 non-specific DNA binding site [nucleotide binding]; other site 585055014751 salt bridge; other site 585055014752 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 585055014753 sequence-specific DNA binding site [nucleotide binding]; other site 585055014754 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 585055014755 active site 585055014756 (T/H)XGH motif; other site 585055014757 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 585055014758 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 585055014759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585055014760 Walker A/P-loop; other site 585055014761 ATP binding site [chemical binding]; other site 585055014762 Q-loop/lid; other site 585055014763 ABC transporter signature motif; other site 585055014764 Walker B; other site 585055014765 D-loop; other site 585055014766 H-loop/switch region; other site 585055014767 ABC transporter; Region: ABC_tran_2; pfam12848 585055014768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585055014769 lytic murein transglycosylase; Provisional; Region: PRK11619 585055014770 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585055014771 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585055014772 catalytic residue [active] 585055014773 Trp operon repressor; Provisional; Region: PRK01381 585055014774 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 585055014775 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585055014776 catalytic core [active] 585055014777 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585055014778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585055014779 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 585055014780 hypothetical protein; Provisional; Region: PRK10756 585055014781 CreA protein; Region: CreA; pfam05981 585055014782 DNA-binding response regulator CreB; Provisional; Region: PRK11083 585055014783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055014784 active site 585055014785 phosphorylation site [posttranslational modification] 585055014786 intermolecular recognition site; other site 585055014787 dimerization interface [polypeptide binding]; other site 585055014788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055014789 DNA binding site [nucleotide binding] 585055014790 sensory histidine kinase CreC; Provisional; Region: PRK11100 585055014791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585055014792 dimerization interface [polypeptide binding]; other site 585055014793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585055014794 dimer interface [polypeptide binding]; other site 585055014795 phosphorylation site [posttranslational modification] 585055014796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585055014797 ATP binding site [chemical binding]; other site 585055014798 Mg2+ binding site [ion binding]; other site 585055014799 G-X-G motif; other site 585055014800 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 585055014801 two-component response regulator; Provisional; Region: PRK11173 585055014802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585055014803 active site 585055014804 phosphorylation site [posttranslational modification] 585055014805 intermolecular recognition site; other site 585055014806 dimerization interface [polypeptide binding]; other site 585055014807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585055014808 DNA binding site [nucleotide binding] 585055014809 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 585055014810 Helix-turn-helix domain; Region: HTH_38; pfam13936 585055014811 Integrase core domain; Region: rve; pfam00665 585055014812 putative RNA methyltransferase; Provisional; Region: PRK10433 585055014813 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050