-- dump date 20140619_081725 -- class Genbank::misc_feature -- table misc_feature_note -- id note 199310000001 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310000002 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 199310000003 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 199310000004 putative catalytic residues [active] 199310000005 putative nucleotide binding site [chemical binding]; other site 199310000006 putative aspartate binding site [chemical binding]; other site 199310000007 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 199310000008 dimer interface [polypeptide binding]; other site 199310000009 putative threonine allosteric regulatory site; other site 199310000010 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 199310000011 putative threonine allosteric regulatory site; other site 199310000012 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 199310000013 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 199310000014 homoserine kinase; Region: thrB; TIGR00191 199310000015 Protein of unknown function; Region: YhfT; pfam10797 199310000016 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 199310000017 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 199310000018 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 199310000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310000020 catalytic residue [active] 199310000021 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 199310000022 hypothetical protein; Validated; Region: PRK02101 199310000023 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 199310000024 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 199310000025 transaldolase-like protein; Provisional; Region: PTZ00411 199310000026 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 199310000027 active site 199310000028 dimer interface [polypeptide binding]; other site 199310000029 catalytic residue [active] 199310000030 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 199310000031 MPT binding site; other site 199310000032 trimer interface [polypeptide binding]; other site 199310000033 hypothetical protein; Provisional; Region: PRK10659 199310000034 hypothetical protein; Provisional; Region: PRK10236 199310000035 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 199310000036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 199310000037 hypothetical protein; Provisional; Region: PRK10154 199310000038 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 199310000039 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 199310000040 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 199310000041 nucleotide binding site [chemical binding]; other site 199310000042 NEF interaction site [polypeptide binding]; other site 199310000043 SBD interface [polypeptide binding]; other site 199310000044 chaperone protein DnaJ; Provisional; Region: PRK10767 199310000045 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 199310000046 HSP70 interaction site [polypeptide binding]; other site 199310000047 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 199310000048 substrate binding site [polypeptide binding]; other site 199310000049 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 199310000050 Zn binding sites [ion binding]; other site 199310000051 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 199310000052 dimer interface [polypeptide binding]; other site 199310000053 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 199310000054 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 199310000055 Sulfatase; Region: Sulfatase; pfam00884 199310000056 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 199310000057 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 199310000058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310000059 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 199310000060 putative dimerization interface [polypeptide binding]; other site 199310000061 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 199310000062 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 199310000063 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 199310000064 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 199310000065 active site 199310000066 Riboflavin kinase; Region: Flavokinase; smart00904 199310000067 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 199310000068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 199310000069 HIGH motif; other site 199310000070 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 199310000071 active site 199310000072 KMSKS motif; other site 199310000073 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 199310000074 tRNA binding surface [nucleotide binding]; other site 199310000075 anticodon binding site; other site 199310000076 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 199310000077 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 199310000078 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 199310000079 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 199310000080 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 199310000081 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 199310000082 Protein of unknown function (DUF805); Region: DUF805; pfam05656 199310000083 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 199310000084 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 199310000085 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 199310000086 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 199310000087 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 199310000088 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 199310000089 catalytic site [active] 199310000090 subunit interface [polypeptide binding]; other site 199310000091 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 199310000092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 199310000093 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 199310000094 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 199310000095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 199310000096 ATP-grasp domain; Region: ATP-grasp_4; cl17255 199310000097 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 199310000098 IMP binding site; other site 199310000099 dimer interface [polypeptide binding]; other site 199310000100 interdomain contacts; other site 199310000101 partial ornithine binding site; other site 199310000102 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 199310000103 carnitine operon protein CaiE; Provisional; Region: PRK13627 199310000104 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 199310000105 putative trimer interface [polypeptide binding]; other site 199310000106 putative metal binding site [ion binding]; other site 199310000107 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 199310000108 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 199310000109 substrate binding site [chemical binding]; other site 199310000110 oxyanion hole (OAH) forming residues; other site 199310000111 trimer interface [polypeptide binding]; other site 199310000112 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 199310000113 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 199310000114 acyl-activating enzyme (AAE) consensus motif; other site 199310000115 putative AMP binding site [chemical binding]; other site 199310000116 putative active site [active] 199310000117 putative CoA binding site [chemical binding]; other site 199310000118 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 199310000119 CoA-transferase family III; Region: CoA_transf_3; pfam02515 199310000120 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 199310000121 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 199310000122 active site 199310000123 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 199310000124 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 199310000125 Ligand binding site [chemical binding]; other site 199310000126 Electron transfer flavoprotein domain; Region: ETF; pfam01012 199310000127 putative oxidoreductase FixC; Provisional; Region: PRK10157 199310000128 ferredoxin-like protein FixX; Provisional; Region: PRK15449 199310000129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310000130 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 199310000131 putative substrate translocation pore; other site 199310000132 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 199310000133 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 199310000134 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 199310000135 TrkA-N domain; Region: TrkA_N; pfam02254 199310000136 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 199310000137 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 199310000138 folate binding site [chemical binding]; other site 199310000139 NADP+ binding site [chemical binding]; other site 199310000140 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 199310000141 CcdB protein; Region: CcdB; pfam01845 199310000142 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 199310000143 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 199310000144 active site 199310000145 metal binding site [ion binding]; metal-binding site 199310000146 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 199310000147 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 199310000148 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 199310000149 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 199310000150 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 199310000151 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 199310000152 SurA N-terminal domain; Region: SurA_N; pfam09312 199310000153 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 199310000154 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 199310000155 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 199310000156 OstA-like protein; Region: OstA; pfam03968 199310000157 Organic solvent tolerance protein; Region: OstA_C; pfam04453 199310000158 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 199310000159 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 199310000160 putative metal binding site [ion binding]; other site 199310000161 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 199310000162 HSP70 interaction site [polypeptide binding]; other site 199310000163 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 199310000164 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 199310000165 active site 199310000166 ATP-dependent helicase HepA; Validated; Region: PRK04914 199310000167 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310000168 ATP binding site [chemical binding]; other site 199310000169 putative Mg++ binding site [ion binding]; other site 199310000170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310000171 nucleotide binding region [chemical binding]; other site 199310000172 ATP-binding site [chemical binding]; other site 199310000173 DNA polymerase II; Reviewed; Region: PRK05762 199310000174 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 199310000175 active site 199310000176 catalytic site [active] 199310000177 substrate binding site [chemical binding]; other site 199310000178 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 199310000179 active site 199310000180 metal-binding site 199310000181 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310000182 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 199310000183 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 199310000184 intersubunit interface [polypeptide binding]; other site 199310000185 active site 199310000186 Zn2+ binding site [ion binding]; other site 199310000187 L-arabinose isomerase; Provisional; Region: PRK02929 199310000188 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 199310000189 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 199310000190 trimer interface [polypeptide binding]; other site 199310000191 putative substrate binding site [chemical binding]; other site 199310000192 putative metal binding site [ion binding]; other site 199310000193 ribulokinase; Provisional; Region: PRK04123 199310000194 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 199310000195 N- and C-terminal domain interface [polypeptide binding]; other site 199310000196 active site 199310000197 MgATP binding site [chemical binding]; other site 199310000198 catalytic site [active] 199310000199 metal binding site [ion binding]; metal-binding site 199310000200 carbohydrate binding site [chemical binding]; other site 199310000201 homodimer interface [polypeptide binding]; other site 199310000202 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 199310000203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 199310000204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310000206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 199310000207 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 199310000208 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 199310000209 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 199310000210 Walker A/P-loop; other site 199310000211 ATP binding site [chemical binding]; other site 199310000212 Q-loop/lid; other site 199310000213 ABC transporter signature motif; other site 199310000214 Walker B; other site 199310000215 D-loop; other site 199310000216 H-loop/switch region; other site 199310000217 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 199310000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310000219 dimer interface [polypeptide binding]; other site 199310000220 conserved gate region; other site 199310000221 putative PBP binding loops; other site 199310000222 ABC-ATPase subunit interface; other site 199310000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310000224 dimer interface [polypeptide binding]; other site 199310000225 conserved gate region; other site 199310000226 putative PBP binding loops; other site 199310000227 ABC-ATPase subunit interface; other site 199310000228 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 199310000229 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 199310000230 transcriptional regulator SgrR; Provisional; Region: PRK13626 199310000231 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 199310000232 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 199310000233 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310000234 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 199310000235 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 199310000236 substrate binding site [chemical binding]; other site 199310000237 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 199310000238 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 199310000239 substrate binding site [chemical binding]; other site 199310000240 ligand binding site [chemical binding]; other site 199310000241 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 199310000242 tartrate dehydrogenase; Region: TTC; TIGR02089 199310000243 2-isopropylmalate synthase; Validated; Region: PRK00915 199310000244 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 199310000245 active site 199310000246 catalytic residues [active] 199310000247 metal binding site [ion binding]; metal-binding site 199310000248 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 199310000249 leu operon leader peptide; Provisional; Region: PRK09925 199310000250 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 199310000251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310000252 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 199310000253 putative substrate binding pocket [chemical binding]; other site 199310000254 putative dimerization interface [polypeptide binding]; other site 199310000255 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 199310000256 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 199310000257 PYR/PP interface [polypeptide binding]; other site 199310000258 dimer interface [polypeptide binding]; other site 199310000259 TPP binding site [chemical binding]; other site 199310000260 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 199310000261 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 199310000262 TPP-binding site [chemical binding]; other site 199310000263 dimer interface [polypeptide binding]; other site 199310000264 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 199310000265 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 199310000266 putative valine binding site [chemical binding]; other site 199310000267 dimer interface [polypeptide binding]; other site 199310000268 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 199310000269 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 199310000270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310000271 DNA binding site [nucleotide binding] 199310000272 domain linker motif; other site 199310000273 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 199310000274 dimerization interface [polypeptide binding]; other site 199310000275 ligand binding site [chemical binding]; other site 199310000276 mraZ protein; Region: TIGR00242 199310000277 MraZ protein; Region: MraZ; pfam02381 199310000278 MraZ protein; Region: MraZ; pfam02381 199310000279 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 199310000280 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 199310000281 cell division protein FtsL; Provisional; Region: PRK10772 199310000282 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 199310000283 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 199310000284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 199310000285 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 199310000286 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 199310000287 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 199310000288 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 199310000289 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 199310000290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 199310000291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 199310000292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 199310000293 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 199310000294 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 199310000295 Mg++ binding site [ion binding]; other site 199310000296 putative catalytic motif [active] 199310000297 putative substrate binding site [chemical binding]; other site 199310000298 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 199310000299 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 199310000300 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 199310000301 cell division protein FtsW; Provisional; Region: PRK10774 199310000302 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 199310000303 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 199310000304 active site 199310000305 homodimer interface [polypeptide binding]; other site 199310000306 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 199310000307 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 199310000308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 199310000309 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 199310000310 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 199310000311 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 199310000312 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 199310000313 cell division protein FtsQ; Provisional; Region: PRK10775 199310000314 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 199310000315 Cell division protein FtsQ; Region: FtsQ; pfam03799 199310000316 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 199310000317 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310000318 Cell division protein FtsA; Region: FtsA; pfam14450 199310000319 cell division protein FtsZ; Validated; Region: PRK09330 199310000320 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 199310000321 nucleotide binding site [chemical binding]; other site 199310000322 SulA interaction site; other site 199310000323 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 199310000324 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 199310000325 SecA regulator SecM; Provisional; Region: PRK02943 199310000326 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 199310000327 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 199310000328 SEC-C motif; Region: SEC-C; pfam02810 199310000329 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 199310000330 active site 199310000331 8-oxo-dGMP binding site [chemical binding]; other site 199310000332 nudix motif; other site 199310000333 metal binding site [ion binding]; metal-binding site 199310000334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310000335 Helix-turn-helix domain; Region: HTH_28; pfam13518 199310000336 Helix-turn-helix domain; Region: HTH_28; pfam13518 199310000337 HTH-like domain; Region: HTH_21; pfam13276 199310000338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 199310000339 Integrase core domain; Region: rve; pfam00665 199310000340 Integrase core domain; Region: rve_2; pfam13333 199310000341 Thiamine pyrophosphokinase; Region: TPK; cl08415 199310000342 DNA gyrase inhibitor; Reviewed; Region: PRK00418 199310000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 199310000344 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 199310000345 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 199310000346 CoA-binding site [chemical binding]; other site 199310000347 ATP-binding [chemical binding]; other site 199310000348 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 199310000349 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 199310000350 active site 199310000351 type IV pilin biogenesis protein; Provisional; Region: PRK10573 199310000352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 199310000353 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 199310000354 hypothetical protein; Provisional; Region: PRK10436 199310000355 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 199310000356 Walker A motif; other site 199310000357 ATP binding site [chemical binding]; other site 199310000358 Walker B motif; other site 199310000359 putative major pilin subunit; Provisional; Region: PRK10574 199310000360 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 199310000361 Pilin (bacterial filament); Region: Pilin; pfam00114 199310000362 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 199310000363 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 199310000364 dimerization interface [polypeptide binding]; other site 199310000365 active site 199310000366 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 199310000367 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 199310000368 amidase catalytic site [active] 199310000369 Zn binding residues [ion binding]; other site 199310000370 substrate binding site [chemical binding]; other site 199310000371 regulatory protein AmpE; Provisional; Region: PRK10987 199310000372 aromatic amino acid transporter; Provisional; Region: PRK10238 199310000373 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 199310000374 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 199310000375 Transposase; Region: HTH_Tnp_1; cl17663 199310000376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310000377 putative transposase OrfB; Reviewed; Region: PHA02517 199310000378 HTH-like domain; Region: HTH_21; pfam13276 199310000379 Integrase core domain; Region: rve; pfam00665 199310000380 Integrase core domain; Region: rve_3; pfam13683 199310000381 Transcriptional regulators [Transcription]; Region: FadR; COG2186 199310000382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310000383 DNA-binding site [nucleotide binding]; DNA binding site 199310000384 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310000385 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 199310000386 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 199310000387 dimer interface [polypeptide binding]; other site 199310000388 TPP-binding site [chemical binding]; other site 199310000389 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 199310000390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 199310000391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310000392 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 199310000393 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 199310000394 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 199310000395 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 199310000396 substrate binding site [chemical binding]; other site 199310000397 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 199310000398 substrate binding site [chemical binding]; other site 199310000399 ligand binding site [chemical binding]; other site 199310000400 hypothetical protein; Provisional; Region: PRK05248 199310000401 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 199310000402 spermidine synthase; Provisional; Region: PRK00811 199310000403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310000404 S-adenosylmethionine binding site [chemical binding]; other site 199310000405 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 199310000406 multicopper oxidase; Provisional; Region: PRK10965 199310000407 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 199310000408 Multicopper oxidase; Region: Cu-oxidase; pfam00394 199310000409 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 199310000410 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 199310000411 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 199310000412 Trp docking motif [polypeptide binding]; other site 199310000413 putative active site [active] 199310000414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310000415 active site 199310000416 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 199310000417 active site clefts [active] 199310000418 zinc binding site [ion binding]; other site 199310000419 dimer interface [polypeptide binding]; other site 199310000420 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 199310000421 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 199310000422 Walker A/P-loop; other site 199310000423 ATP binding site [chemical binding]; other site 199310000424 Q-loop/lid; other site 199310000425 ABC transporter signature motif; other site 199310000426 Walker B; other site 199310000427 D-loop; other site 199310000428 H-loop/switch region; other site 199310000429 inner membrane transport permease; Provisional; Region: PRK15066 199310000430 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 199310000431 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 199310000432 active pocket/dimerization site; other site 199310000433 active site 199310000434 phosphorylation site [posttranslational modification] 199310000435 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 199310000436 putative active site [active] 199310000437 putative metal binding site [ion binding]; other site 199310000438 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 199310000439 tetramerization interface [polypeptide binding]; other site 199310000440 active site 199310000441 Uncharacterized conserved protein [Function unknown]; Region: COG5464 199310000442 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 199310000443 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 199310000444 pantoate--beta-alanine ligase; Region: panC; TIGR00018 199310000445 Pantoate-beta-alanine ligase; Region: PanC; cd00560 199310000446 active site 199310000447 ATP-binding site [chemical binding]; other site 199310000448 pantoate-binding site; other site 199310000449 HXXH motif; other site 199310000450 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 199310000451 oligomerization interface [polypeptide binding]; other site 199310000452 active site 199310000453 metal binding site [ion binding]; metal-binding site 199310000454 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 199310000455 putative fimbrial protein StaF; Provisional; Region: PRK15262 199310000456 putative fimbrial protein StaE; Provisional; Region: PRK15263 199310000457 Fimbrial protein; Region: Fimbrial; cl01416 199310000458 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 199310000459 PapC N-terminal domain; Region: PapC_N; pfam13954 199310000460 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310000461 PapC C-terminal domain; Region: PapC_C; pfam13953 199310000462 putative chaperone protein EcpD; Provisional; Region: PRK09926 199310000463 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310000464 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310000465 Fimbrial protein; Region: Fimbrial; cl01416 199310000466 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 199310000467 catalytic center binding site [active] 199310000468 ATP binding site [chemical binding]; other site 199310000469 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 199310000470 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 199310000471 active site 199310000472 NTP binding site [chemical binding]; other site 199310000473 metal binding triad [ion binding]; metal-binding site 199310000474 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 199310000475 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 199310000476 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 199310000477 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 199310000478 active site 199310000479 nucleotide binding site [chemical binding]; other site 199310000480 HIGH motif; other site 199310000481 KMSKS motif; other site 199310000482 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 199310000483 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 199310000484 2'-5' RNA ligase; Provisional; Region: PRK15124 199310000485 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 199310000486 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 199310000487 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 199310000488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310000489 ATP binding site [chemical binding]; other site 199310000490 putative Mg++ binding site [ion binding]; other site 199310000491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310000492 nucleotide binding region [chemical binding]; other site 199310000493 ATP-binding site [chemical binding]; other site 199310000494 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 199310000495 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 199310000496 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 199310000497 Transglycosylase; Region: Transgly; pfam00912 199310000498 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 199310000499 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 199310000500 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310000501 N-terminal plug; other site 199310000502 ligand-binding site [chemical binding]; other site 199310000503 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 199310000504 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310000505 Walker A/P-loop; other site 199310000506 ATP binding site [chemical binding]; other site 199310000507 Q-loop/lid; other site 199310000508 ABC transporter signature motif; other site 199310000509 Walker B; other site 199310000510 D-loop; other site 199310000511 H-loop/switch region; other site 199310000512 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 199310000513 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 199310000514 siderophore binding site; other site 199310000515 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 199310000516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310000517 ABC-ATPase subunit interface; other site 199310000518 dimer interface [polypeptide binding]; other site 199310000519 putative PBP binding regions; other site 199310000520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310000521 ABC-ATPase subunit interface; other site 199310000522 dimer interface [polypeptide binding]; other site 199310000523 putative PBP binding regions; other site 199310000524 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 199310000525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 199310000526 inhibitor-cofactor binding pocket; inhibition site 199310000527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310000528 catalytic residue [active] 199310000529 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 199310000530 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 199310000531 Cl- selectivity filter; other site 199310000532 Cl- binding residues [ion binding]; other site 199310000533 pore gating glutamate residue; other site 199310000534 dimer interface [polypeptide binding]; other site 199310000535 H+/Cl- coupling transport residue; other site 199310000536 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 199310000537 hypothetical protein; Provisional; Region: PRK10578 199310000538 UPF0126 domain; Region: UPF0126; pfam03458 199310000539 UPF0126 domain; Region: UPF0126; pfam03458 199310000540 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 199310000541 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 199310000542 cobalamin binding residues [chemical binding]; other site 199310000543 putative BtuC binding residues; other site 199310000544 dimer interface [polypeptide binding]; other site 199310000545 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 199310000546 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 199310000547 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 199310000548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 199310000549 Zn2+ binding site [ion binding]; other site 199310000550 Mg2+ binding site [ion binding]; other site 199310000551 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 199310000552 serine endoprotease; Provisional; Region: PRK10942 199310000553 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 199310000554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 199310000555 protein binding site [polypeptide binding]; other site 199310000556 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 199310000557 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310000558 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 199310000559 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 199310000560 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 199310000561 hypothetical protein; Provisional; Region: PRK13677 199310000562 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 199310000563 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 199310000564 trimer interface [polypeptide binding]; other site 199310000565 active site 199310000566 substrate binding site [chemical binding]; other site 199310000567 CoA binding site [chemical binding]; other site 199310000568 PII uridylyl-transferase; Provisional; Region: PRK05007 199310000569 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 199310000570 metal binding triad; other site 199310000571 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 199310000572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 199310000573 Zn2+ binding site [ion binding]; other site 199310000574 Mg2+ binding site [ion binding]; other site 199310000575 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 199310000576 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 199310000577 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 199310000578 active site 199310000579 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 199310000580 rRNA interaction site [nucleotide binding]; other site 199310000581 S8 interaction site; other site 199310000582 putative laminin-1 binding site; other site 199310000583 elongation factor Ts; Provisional; Region: tsf; PRK09377 199310000584 UBA/TS-N domain; Region: UBA; pfam00627 199310000585 Elongation factor TS; Region: EF_TS; pfam00889 199310000586 Elongation factor TS; Region: EF_TS; pfam00889 199310000587 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 199310000588 putative nucleotide binding site [chemical binding]; other site 199310000589 uridine monophosphate binding site [chemical binding]; other site 199310000590 homohexameric interface [polypeptide binding]; other site 199310000591 ribosome recycling factor; Reviewed; Region: frr; PRK00083 199310000592 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 199310000593 hinge region; other site 199310000594 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 199310000595 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 199310000596 catalytic residue [active] 199310000597 putative FPP diphosphate binding site; other site 199310000598 putative FPP binding hydrophobic cleft; other site 199310000599 dimer interface [polypeptide binding]; other site 199310000600 putative IPP diphosphate binding site; other site 199310000601 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 199310000602 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 199310000603 zinc metallopeptidase RseP; Provisional; Region: PRK10779 199310000604 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 199310000605 active site 199310000606 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 199310000607 protein binding site [polypeptide binding]; other site 199310000608 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 199310000609 putative substrate binding region [chemical binding]; other site 199310000610 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 199310000611 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 199310000612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 199310000613 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 199310000614 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 199310000615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 199310000616 Surface antigen; Region: Bac_surface_Ag; pfam01103 199310000617 periplasmic chaperone; Provisional; Region: PRK10780 199310000618 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 199310000619 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 199310000620 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 199310000621 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 199310000622 trimer interface [polypeptide binding]; other site 199310000623 active site 199310000624 UDP-GlcNAc binding site [chemical binding]; other site 199310000625 lipid binding site [chemical binding]; lipid-binding site 199310000626 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 199310000627 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 199310000628 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 199310000629 active site 199310000630 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 199310000631 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 199310000632 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 199310000633 RNA/DNA hybrid binding site [nucleotide binding]; other site 199310000634 active site 199310000635 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 199310000636 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 199310000637 putative active site [active] 199310000638 putative PHP Thumb interface [polypeptide binding]; other site 199310000639 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 199310000640 generic binding surface II; other site 199310000641 generic binding surface I; other site 199310000642 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 199310000643 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 199310000644 lysine decarboxylase LdcC; Provisional; Region: PRK15399 199310000645 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 199310000646 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 199310000647 homodimer interface [polypeptide binding]; other site 199310000648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310000649 catalytic residue [active] 199310000650 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 199310000651 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 199310000652 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 199310000653 putative metal binding site [ion binding]; other site 199310000654 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 199310000655 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 199310000656 Ligand Binding Site [chemical binding]; other site 199310000657 TilS substrate binding domain; Region: TilS; pfam09179 199310000658 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 199310000659 Rho-binding antiterminator; Provisional; Region: PRK11625 199310000660 hypothetical protein; Provisional; Region: PRK04964 199310000661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 199310000662 hypothetical protein; Provisional; Region: PRK09256 199310000663 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 199310000664 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 199310000665 NlpE N-terminal domain; Region: NlpE; pfam04170 199310000666 HTH-like domain; Region: HTH_21; pfam13276 199310000667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 199310000668 Integrase core domain; Region: rve; pfam00665 199310000669 Integrase core domain; Region: rve_2; pfam13333 199310000670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310000671 Helix-turn-helix domain; Region: HTH_28; pfam13518 199310000672 Helix-turn-helix domain; Region: HTH_28; pfam13518 199310000673 hypothetical protein; Provisional; Region: PRK11479 199310000674 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 199310000675 prolyl-tRNA synthetase; Provisional; Region: PRK09194 199310000676 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 199310000677 dimer interface [polypeptide binding]; other site 199310000678 motif 1; other site 199310000679 active site 199310000680 motif 2; other site 199310000681 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 199310000682 putative deacylase active site [active] 199310000683 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 199310000684 active site 199310000685 motif 3; other site 199310000686 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 199310000687 anticodon binding site; other site 199310000688 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 199310000689 homodimer interaction site [polypeptide binding]; other site 199310000690 cofactor binding site; other site 199310000691 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 199310000692 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 199310000693 lipoprotein, YaeC family; Region: TIGR00363 199310000694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310000695 dimer interface [polypeptide binding]; other site 199310000696 conserved gate region; other site 199310000697 ABC-ATPase subunit interface; other site 199310000698 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 199310000699 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 199310000700 Walker A/P-loop; other site 199310000701 ATP binding site [chemical binding]; other site 199310000702 Q-loop/lid; other site 199310000703 ABC transporter signature motif; other site 199310000704 Walker B; other site 199310000705 D-loop; other site 199310000706 H-loop/switch region; other site 199310000707 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 199310000708 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 199310000709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310000710 active site 199310000711 motif I; other site 199310000712 motif II; other site 199310000713 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310000714 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310000715 active site 199310000716 catalytic tetrad [active] 199310000717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310000718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310000719 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 199310000720 putative effector binding pocket; other site 199310000721 dimerization interface [polypeptide binding]; other site 199310000722 hypothetical protein; Provisional; Region: PRK05421 199310000723 putative catalytic site [active] 199310000724 putative metal binding site [ion binding]; other site 199310000725 putative phosphate binding site [ion binding]; other site 199310000726 putative catalytic site [active] 199310000727 putative phosphate binding site [ion binding]; other site 199310000728 putative metal binding site [ion binding]; other site 199310000729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310000730 S-adenosylmethionine binding site [chemical binding]; other site 199310000731 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 199310000732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 199310000733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 199310000734 catalytic residue [active] 199310000735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310000736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310000737 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 199310000738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310000739 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 199310000740 RNA/DNA hybrid binding site [nucleotide binding]; other site 199310000741 active site 199310000742 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 199310000743 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 199310000744 active site 199310000745 catalytic site [active] 199310000746 substrate binding site [chemical binding]; other site 199310000747 Methyltransferase domain; Region: Methyltransf_27; pfam13708 199310000748 Methyltransferase domain; Region: Methyltransf_27; pfam13708 199310000749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310000750 Transposase; Region: HTH_Tnp_1; pfam01527 199310000751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310000752 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 199310000753 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310000754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310000755 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 199310000756 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310000757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310000758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 199310000759 Transposase; Region: DEDD_Tnp_IS110; pfam01548 199310000760 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 199310000761 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310000762 Homeodomain-like domain; Region: HTH_23; pfam13384 199310000763 Winged helix-turn helix; Region: HTH_29; pfam13551 199310000764 Homeodomain-like domain; Region: HTH_32; pfam13565 199310000765 DDE superfamily endonuclease; Region: DDE_3; pfam13358 199310000766 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 199310000767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310000768 Walker A motif; other site 199310000769 ATP binding site [chemical binding]; other site 199310000770 Walker B motif; other site 199310000771 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 199310000772 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 199310000773 Protein of unknown function (DUF987); Region: DUF987; pfam06174 199310000774 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 199310000775 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 199310000776 MPN+ (JAMM) motif; other site 199310000777 Zinc-binding site [ion binding]; other site 199310000778 Antirestriction protein; Region: Antirestrict; pfam03230 199310000779 Domain of unknown function (DUF932); Region: DUF932; pfam06067 199310000780 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 199310000781 Photosystem II protein; Region: PSII; cl08223 199310000782 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 199310000783 nucleophile elbow; other site 199310000784 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 199310000785 YjcZ-like protein; Region: YjcZ; pfam13990 199310000786 hypothetical protein; Provisional; Region: PRK09866 199310000787 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 199310000788 G3 box; other site 199310000789 Switch II region; other site 199310000790 GTP/Mg2+ binding site [chemical binding]; other site 199310000791 G4 box; other site 199310000792 G5 box; other site 199310000793 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 199310000794 G1 box; other site 199310000795 GTP/Mg2+ binding site [chemical binding]; other site 199310000796 G2 box; other site 199310000797 Switch I region; other site 199310000798 Predicted GTPase [General function prediction only]; Region: COG3596 199310000799 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 199310000800 G1 box; other site 199310000801 GTP/Mg2+ binding site [chemical binding]; other site 199310000802 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 199310000803 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310000804 active site 199310000805 DNA binding site [nucleotide binding] 199310000806 Int/Topo IB signature motif; other site 199310000807 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 199310000808 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310000809 N-terminal plug; other site 199310000810 ligand-binding site [chemical binding]; other site 199310000811 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 199310000812 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 199310000813 putative ligand binding residues [chemical binding]; other site 199310000814 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310000815 dimer interface [polypeptide binding]; other site 199310000816 putative PBP binding regions; other site 199310000817 ABC-ATPase subunit interface; other site 199310000818 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 199310000819 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310000820 Walker A/P-loop; other site 199310000821 ATP binding site [chemical binding]; other site 199310000822 Q-loop/lid; other site 199310000823 ABC transporter signature motif; other site 199310000824 Walker B; other site 199310000825 D-loop; other site 199310000826 H-loop/switch region; other site 199310000827 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 199310000828 Haemolysin expression modulating protein; Region: HHA; pfam05321 199310000829 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310000830 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 199310000831 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 199310000832 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310000833 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310000834 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 199310000835 hypothetical protein; Provisional; Region: PRK09273 199310000836 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 199310000837 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 199310000838 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 199310000839 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 199310000840 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 199310000841 NADP binding site [chemical binding]; other site 199310000842 homodimer interface [polypeptide binding]; other site 199310000843 active site 199310000844 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 199310000845 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 199310000846 Right handed beta helix region; Region: Beta_helix; pfam13229 199310000847 CAAX protease self-immunity; Region: Abi; pfam02517 199310000848 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 199310000849 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 199310000850 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310000851 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310000852 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 199310000853 substrate binding site [chemical binding]; other site 199310000854 dimer interface [polypeptide binding]; other site 199310000855 ATP binding site [chemical binding]; other site 199310000856 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 199310000857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310000858 putative substrate translocation pore; other site 199310000859 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 199310000860 active site 199310000861 catalytic residues [active] 199310000862 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 199310000863 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 199310000864 active site 199310000865 P-loop; other site 199310000866 phosphorylation site [posttranslational modification] 199310000867 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310000868 active site 199310000869 phosphorylation site [posttranslational modification] 199310000870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 199310000871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310000872 DNA binding site [nucleotide binding] 199310000873 domain linker motif; other site 199310000874 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 199310000875 putative dimerization interface [polypeptide binding]; other site 199310000876 putative ligand binding site [chemical binding]; other site 199310000877 haemagglutination activity domain; Region: Haemagg_act; pfam05860 199310000878 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 199310000879 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 199310000880 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 199310000881 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 199310000882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 199310000883 MULE transposase domain; Region: MULE; pfam10551 199310000884 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 199310000885 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 199310000886 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310000887 Autotransporter beta-domain; Region: Autotransporter; pfam03797 199310000888 Integrase core domain; Region: rve_3; cl15866 199310000889 Transposase; Region: HTH_Tnp_1; cl17663 199310000890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310000891 Transposase; Region: DDE_Tnp_ISL3; pfam01610 199310000892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 199310000893 Transposase; Region: DDE_Tnp_ISL3; pfam01610 199310000894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 199310000895 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 199310000896 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 199310000897 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 199310000898 putative active site [active] 199310000899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310000900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310000901 Walker A/P-loop; other site 199310000902 ATP binding site [chemical binding]; other site 199310000903 Q-loop/lid; other site 199310000904 ABC transporter signature motif; other site 199310000905 Walker B; other site 199310000906 D-loop; other site 199310000907 H-loop/switch region; other site 199310000908 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 199310000909 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310000910 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310000911 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 199310000912 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 199310000913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 199310000914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310000915 DNA binding residues [nucleotide binding] 199310000916 dimerization interface [polypeptide binding]; other site 199310000917 DDE superfamily endonuclease; Region: DDE_3; pfam13358 199310000918 Homeodomain-like domain; Region: HTH_23; pfam13384 199310000919 Winged helix-turn helix; Region: HTH_29; pfam13551 199310000920 Winged helix-turn helix; Region: HTH_33; pfam13592 199310000921 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 199310000922 C-N hydrolase family amidase; Provisional; Region: PRK10438 199310000923 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 199310000924 putative active site [active] 199310000925 catalytic triad [active] 199310000926 dimer interface [polypeptide binding]; other site 199310000927 multimer interface [polypeptide binding]; other site 199310000928 C-lysozyme inhibitor; Provisional; Region: PRK09993 199310000929 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 199310000930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 199310000931 active site 199310000932 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 199310000933 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 199310000934 dimer interface [polypeptide binding]; other site 199310000935 active site 199310000936 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 199310000937 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 199310000938 putative active site [active] 199310000939 putative dimer interface [polypeptide binding]; other site 199310000940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 199310000941 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 199310000942 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 199310000943 NlpC/P60 family; Region: NLPC_P60; pfam00877 199310000944 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 199310000945 FHIPEP family; Region: FHIPEP; pfam00771 199310000946 hypothetical protein; Validated; Region: PRK06778 199310000947 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 199310000948 ligand binding site [chemical binding]; other site 199310000949 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 199310000950 active site 199310000951 DNA polymerase IV; Validated; Region: PRK02406 199310000952 DNA binding site [nucleotide binding] 199310000953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 199310000954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310000955 Coenzyme A binding pocket [chemical binding]; other site 199310000956 hypothetical protein; Reviewed; Region: PRK09588 199310000957 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 199310000958 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 199310000959 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 199310000960 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 199310000961 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 199310000962 metal binding site [ion binding]; metal-binding site 199310000963 dimer interface [polypeptide binding]; other site 199310000964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310000965 active site 199310000966 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 199310000967 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 199310000968 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 199310000969 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 199310000970 trimer interface [polypeptide binding]; other site 199310000971 eyelet of channel; other site 199310000972 gamma-glutamyl kinase; Provisional; Region: PRK05429 199310000973 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 199310000974 nucleotide binding site [chemical binding]; other site 199310000975 homotetrameric interface [polypeptide binding]; other site 199310000976 putative phosphate binding site [ion binding]; other site 199310000977 putative allosteric binding site; other site 199310000978 PUA domain; Region: PUA; pfam01472 199310000979 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 199310000980 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 199310000981 putative catalytic cysteine [active] 199310000982 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 199310000983 MarR family; Region: MarR_2; cl17246 199310000984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 199310000985 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 199310000986 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 199310000987 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 199310000988 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310000989 Autotransporter beta-domain; Region: Autotransporter; pfam03797 199310000990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 199310000991 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 199310000992 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 199310000993 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 199310000994 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 199310000995 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 199310000996 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310000997 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 199310000998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 199310000999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310001000 DNA binding residues [nucleotide binding] 199310001001 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 199310001002 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 199310001003 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 199310001004 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 199310001005 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 199310001006 putative active site [active] 199310001007 putative FMN binding site [chemical binding]; other site 199310001008 putative substrate binding site [chemical binding]; other site 199310001009 putative catalytic residue [active] 199310001010 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 199310001011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310001012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310001013 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 199310001014 putative effector binding pocket; other site 199310001015 putative dimerization interface [polypeptide binding]; other site 199310001016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310001017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310001018 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 199310001019 putative effector binding pocket; other site 199310001020 putative dimerization interface [polypeptide binding]; other site 199310001021 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310001022 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310001023 active site 199310001024 catalytic tetrad [active] 199310001025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310001026 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310001027 active site 199310001028 catalytic tetrad [active] 199310001029 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 199310001030 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 199310001031 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 199310001032 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 199310001033 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 199310001034 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 199310001035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310001036 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 199310001037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310001038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310001039 active site 199310001040 catalytic tetrad [active] 199310001041 Predicted membrane protein [Function unknown]; Region: COG3059 199310001042 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310001043 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 199310001044 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 199310001045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310001046 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 199310001047 Cupin; Region: Cupin_6; pfam12852 199310001048 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 199310001049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310001050 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 199310001051 Cysteine-rich domain; Region: CCG; pfam02754 199310001052 Cysteine-rich domain; Region: CCG; pfam02754 199310001053 iron-sulfur cluster-binding protein; Region: TIGR00273 199310001054 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 199310001055 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 199310001056 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 199310001057 Uncharacterized conserved protein [Function unknown]; Region: COG1556 199310001058 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 199310001059 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 199310001060 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310001061 Autotransporter beta-domain; Region: Autotransporter; pfam03797 199310001062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 199310001063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310001064 DNA binding residues [nucleotide binding] 199310001065 dimerization interface [polypeptide binding]; other site 199310001066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310001067 active site 199310001068 DNA binding site [nucleotide binding] 199310001069 Int/Topo IB signature motif; other site 199310001070 choline dehydrogenase; Validated; Region: PRK02106 199310001071 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 199310001072 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 199310001073 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 199310001074 tetrameric interface [polypeptide binding]; other site 199310001075 NAD binding site [chemical binding]; other site 199310001076 catalytic residues [active] 199310001077 transcriptional regulator BetI; Validated; Region: PRK00767 199310001078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310001079 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 199310001080 choline transport protein BetT; Provisional; Region: PRK09928 199310001081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310001082 DNA binding residues [nucleotide binding] 199310001083 dimerization interface [polypeptide binding]; other site 199310001084 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310001085 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 199310001086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310001087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310001088 dimerization interface [polypeptide binding]; other site 199310001089 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 199310001090 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 199310001091 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 199310001092 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 199310001093 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 199310001094 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 199310001095 CoA binding domain; Region: CoA_binding; pfam02629 199310001096 CoA-ligase; Region: Ligase_CoA; pfam00549 199310001097 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 199310001098 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 199310001099 putative substrate binding site [chemical binding]; other site 199310001100 nucleotide binding site [chemical binding]; other site 199310001101 nucleotide binding site [chemical binding]; other site 199310001102 homodimer interface [polypeptide binding]; other site 199310001103 putative deaminase; Validated; Region: PRK06846 199310001104 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 199310001105 active site 199310001106 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 199310001107 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 199310001108 putative NAD(P) binding site [chemical binding]; other site 199310001109 putative substrate binding site [chemical binding]; other site 199310001110 catalytic Zn binding site [ion binding]; other site 199310001111 structural Zn binding site [ion binding]; other site 199310001112 dimer interface [polypeptide binding]; other site 199310001113 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 199310001114 hypothetical protein; Provisional; Region: PRK09929 199310001115 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 199310001116 Propionate catabolism activator; Region: PrpR_N; pfam06506 199310001117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310001118 Walker A motif; other site 199310001119 ATP binding site [chemical binding]; other site 199310001120 Walker B motif; other site 199310001121 arginine finger; other site 199310001122 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310001123 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 199310001124 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 199310001125 tetramer interface [polypeptide binding]; other site 199310001126 active site 199310001127 Mg2+/Mn2+ binding site [ion binding]; other site 199310001128 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 199310001129 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 199310001130 dimer interface [polypeptide binding]; other site 199310001131 active site 199310001132 citrylCoA binding site [chemical binding]; other site 199310001133 oxalacetate/citrate binding site [chemical binding]; other site 199310001134 coenzyme A binding site [chemical binding]; other site 199310001135 catalytic triad [active] 199310001136 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 199310001137 2-methylcitrate dehydratase; Region: prpD; TIGR02330 199310001138 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 199310001139 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 199310001140 acyl-activating enzyme (AAE) consensus motif; other site 199310001141 putative AMP binding site [chemical binding]; other site 199310001142 putative active site [active] 199310001143 putative CoA binding site [chemical binding]; other site 199310001144 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 199310001145 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 199310001146 Na binding site [ion binding]; other site 199310001147 putative substrate binding site [chemical binding]; other site 199310001148 cytosine deaminase; Provisional; Region: PRK09230 199310001149 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 199310001150 active site 199310001151 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 199310001152 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 199310001153 active site 199310001154 substrate binding site [chemical binding]; other site 199310001155 trimer interface [polypeptide binding]; other site 199310001156 CoA binding site [chemical binding]; other site 199310001157 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 199310001158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310001159 putative substrate translocation pore; other site 199310001160 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 199310001161 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 199310001162 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 199310001163 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 199310001164 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 199310001165 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 199310001166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 199310001167 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 199310001168 S-formylglutathione hydrolase; Region: PLN02442 199310001169 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 199310001170 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 199310001171 substrate binding site [chemical binding]; other site 199310001172 catalytic Zn binding site [ion binding]; other site 199310001173 NAD binding site [chemical binding]; other site 199310001174 structural Zn binding site [ion binding]; other site 199310001175 dimer interface [polypeptide binding]; other site 199310001176 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 199310001177 putative metal binding site [ion binding]; other site 199310001178 putative homodimer interface [polypeptide binding]; other site 199310001179 putative homotetramer interface [polypeptide binding]; other site 199310001180 putative homodimer-homodimer interface [polypeptide binding]; other site 199310001181 putative allosteric switch controlling residues; other site 199310001182 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 199310001183 putative trimer interface [polypeptide binding]; other site 199310001184 putative CoA binding site [chemical binding]; other site 199310001185 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 199310001186 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 199310001187 DXD motif; other site 199310001188 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 199310001189 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 199310001190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310001191 substrate binding pocket [chemical binding]; other site 199310001192 membrane-bound complex binding site; other site 199310001193 hinge residues; other site 199310001194 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 199310001195 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 199310001196 Walker A/P-loop; other site 199310001197 ATP binding site [chemical binding]; other site 199310001198 Q-loop/lid; other site 199310001199 ABC transporter signature motif; other site 199310001200 Walker B; other site 199310001201 D-loop; other site 199310001202 H-loop/switch region; other site 199310001203 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 199310001204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310001205 dimer interface [polypeptide binding]; other site 199310001206 conserved gate region; other site 199310001207 putative PBP binding loops; other site 199310001208 ABC-ATPase subunit interface; other site 199310001209 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 199310001210 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 199310001211 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 199310001212 dimer interface [polypeptide binding]; other site 199310001213 active site 199310001214 Schiff base residues; other site 199310001215 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 199310001216 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310001217 Autotransporter beta-domain; Region: Autotransporter; pfam03797 199310001218 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 199310001219 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 199310001220 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 199310001221 microcin B17 transporter; Reviewed; Region: PRK11098 199310001222 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 199310001223 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 199310001224 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 199310001225 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 199310001226 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 199310001227 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 199310001228 anti-RssB factor; Provisional; Region: PRK10244 199310001229 alkaline phosphatase; Provisional; Region: PRK10518 199310001230 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 199310001231 dimer interface [polypeptide binding]; other site 199310001232 active site 199310001233 hypothetical protein; Provisional; Region: PRK11505 199310001234 psiF repeat; Region: PsiF_repeat; pfam07769 199310001235 psiF repeat; Region: PsiF_repeat; pfam07769 199310001236 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 199310001237 MASE2 domain; Region: MASE2; pfam05230 199310001238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310001239 metal binding site [ion binding]; metal-binding site 199310001240 active site 199310001241 I-site; other site 199310001242 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 199310001243 pyrroline-5-carboxylate reductase; Region: PLN02688 199310001244 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 199310001245 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 199310001246 ADP binding site [chemical binding]; other site 199310001247 magnesium binding site [ion binding]; other site 199310001248 putative shikimate binding site; other site 199310001249 hypothetical protein; Provisional; Region: PRK10380 199310001250 hypothetical protein; Provisional; Region: PRK10481 199310001251 hypothetical protein; Provisional; Region: PRK10579 199310001252 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 199310001253 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 199310001254 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 199310001255 fructokinase; Reviewed; Region: PRK09557 199310001256 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310001257 nucleotide binding site [chemical binding]; other site 199310001258 MFS transport protein AraJ; Provisional; Region: PRK10091 199310001259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310001260 putative substrate translocation pore; other site 199310001261 exonuclease subunit SbcC; Provisional; Region: PRK10246 199310001262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310001263 Walker A/P-loop; other site 199310001264 ATP binding site [chemical binding]; other site 199310001265 Q-loop/lid; other site 199310001266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310001267 ABC transporter signature motif; other site 199310001268 Walker B; other site 199310001269 D-loop; other site 199310001270 H-loop/switch region; other site 199310001271 exonuclease subunit SbcD; Provisional; Region: PRK10966 199310001272 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 199310001273 active site 199310001274 metal binding site [ion binding]; metal-binding site 199310001275 DNA binding site [nucleotide binding] 199310001276 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 199310001277 transcriptional regulator PhoB; Provisional; Region: PRK10161 199310001278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310001279 active site 199310001280 phosphorylation site [posttranslational modification] 199310001281 intermolecular recognition site; other site 199310001282 dimerization interface [polypeptide binding]; other site 199310001283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310001284 DNA binding site [nucleotide binding] 199310001285 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 199310001286 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 199310001287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310001288 putative active site [active] 199310001289 heme pocket [chemical binding]; other site 199310001290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310001291 dimer interface [polypeptide binding]; other site 199310001292 phosphorylation site [posttranslational modification] 199310001293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310001294 ATP binding site [chemical binding]; other site 199310001295 Mg2+ binding site [ion binding]; other site 199310001296 G-X-G motif; other site 199310001297 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 199310001298 putative proline-specific permease; Provisional; Region: proY; PRK10580 199310001299 Spore germination protein; Region: Spore_permease; cl17796 199310001300 maltodextrin glucosidase; Provisional; Region: PRK10785 199310001301 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 199310001302 homodimer interface [polypeptide binding]; other site 199310001303 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 199310001304 active site 199310001305 homodimer interface [polypeptide binding]; other site 199310001306 catalytic site [active] 199310001307 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 199310001308 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 199310001309 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 199310001310 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 199310001311 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 199310001312 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 199310001313 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 199310001314 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 199310001315 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 199310001316 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 199310001317 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 199310001318 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 199310001319 Protein export membrane protein; Region: SecD_SecF; pfam02355 199310001320 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 199310001321 active site 199310001322 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 199310001323 hypothetical protein; Provisional; Region: PRK11530 199310001324 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 199310001325 ATP cone domain; Region: ATP-cone; pfam03477 199310001326 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 199310001327 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 199310001328 catalytic motif [active] 199310001329 Zn binding site [ion binding]; other site 199310001330 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 199310001331 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 199310001332 homopentamer interface [polypeptide binding]; other site 199310001333 active site 199310001334 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 199310001335 putative RNA binding site [nucleotide binding]; other site 199310001336 thiamine monophosphate kinase; Provisional; Region: PRK05731 199310001337 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 199310001338 ATP binding site [chemical binding]; other site 199310001339 dimerization interface [polypeptide binding]; other site 199310001340 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 199310001341 tetramer interfaces [polypeptide binding]; other site 199310001342 binuclear metal-binding site [ion binding]; other site 199310001343 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310001344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310001345 active site 199310001346 catalytic tetrad [active] 199310001347 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 199310001348 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 199310001349 TPP-binding site; other site 199310001350 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 199310001351 PYR/PP interface [polypeptide binding]; other site 199310001352 dimer interface [polypeptide binding]; other site 199310001353 TPP binding site [chemical binding]; other site 199310001354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 199310001355 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 199310001356 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 199310001357 substrate binding pocket [chemical binding]; other site 199310001358 chain length determination region; other site 199310001359 substrate-Mg2+ binding site; other site 199310001360 catalytic residues [active] 199310001361 aspartate-rich region 1; other site 199310001362 active site lid residues [active] 199310001363 aspartate-rich region 2; other site 199310001364 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 199310001365 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 199310001366 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 199310001367 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 199310001368 Ligand Binding Site [chemical binding]; other site 199310001369 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 199310001370 active site residue [active] 199310001371 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 199310001372 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 199310001373 conserved cys residue [active] 199310001374 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 199310001375 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 199310001376 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 199310001377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 199310001378 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 199310001379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310001380 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310001381 putative substrate translocation pore; other site 199310001382 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 199310001383 UbiA prenyltransferase family; Region: UbiA; pfam01040 199310001384 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 199310001385 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 199310001386 Subunit I/III interface [polypeptide binding]; other site 199310001387 Subunit III/IV interface [polypeptide binding]; other site 199310001388 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 199310001389 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 199310001390 D-pathway; other site 199310001391 Putative ubiquinol binding site [chemical binding]; other site 199310001392 Low-spin heme (heme b) binding site [chemical binding]; other site 199310001393 Putative water exit pathway; other site 199310001394 Binuclear center (heme o3/CuB) [ion binding]; other site 199310001395 K-pathway; other site 199310001396 Putative proton exit pathway; other site 199310001397 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 199310001398 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 199310001399 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 199310001400 muropeptide transporter; Reviewed; Region: ampG; PRK11902 199310001401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310001402 putative substrate translocation pore; other site 199310001403 hypothetical protein; Provisional; Region: PRK11627 199310001404 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 199310001405 transcriptional regulator BolA; Provisional; Region: PRK11628 199310001406 trigger factor; Provisional; Region: tig; PRK01490 199310001407 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 199310001408 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 199310001409 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 199310001410 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 199310001411 oligomer interface [polypeptide binding]; other site 199310001412 active site residues [active] 199310001413 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 199310001414 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 199310001415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310001416 Walker A motif; other site 199310001417 ATP binding site [chemical binding]; other site 199310001418 Walker B motif; other site 199310001419 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 199310001420 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 199310001421 Found in ATP-dependent protease La (LON); Region: LON; smart00464 199310001422 Found in ATP-dependent protease La (LON); Region: LON; smart00464 199310001423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310001424 Walker A motif; other site 199310001425 ATP binding site [chemical binding]; other site 199310001426 Walker B motif; other site 199310001427 arginine finger; other site 199310001428 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 199310001429 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 199310001430 IHF dimer interface [polypeptide binding]; other site 199310001431 IHF - DNA interface [nucleotide binding]; other site 199310001432 periplasmic folding chaperone; Provisional; Region: PRK10788 199310001433 SurA N-terminal domain; Region: SurA_N_3; cl07813 199310001434 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 199310001435 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 199310001436 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 199310001437 active site 199310001438 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 199310001439 Ligand Binding Site [chemical binding]; other site 199310001440 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 199310001441 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 199310001442 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 199310001443 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 199310001444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310001445 active site 199310001446 motif I; other site 199310001447 motif II; other site 199310001448 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310001449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 199310001450 dimerization interface [polypeptide binding]; other site 199310001451 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 199310001452 putative DNA binding site [nucleotide binding]; other site 199310001453 putative Zn2+ binding site [ion binding]; other site 199310001454 AsnC family; Region: AsnC_trans_reg; pfam01037 199310001455 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310001456 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 199310001457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310001458 Walker A/P-loop; other site 199310001459 ATP binding site [chemical binding]; other site 199310001460 Q-loop/lid; other site 199310001461 ABC transporter signature motif; other site 199310001462 Walker B; other site 199310001463 D-loop; other site 199310001464 H-loop/switch region; other site 199310001465 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 199310001466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310001467 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 199310001468 Walker A/P-loop; other site 199310001469 ATP binding site [chemical binding]; other site 199310001470 Q-loop/lid; other site 199310001471 ABC transporter signature motif; other site 199310001472 Walker B; other site 199310001473 D-loop; other site 199310001474 H-loop/switch region; other site 199310001475 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 199310001476 Nitrogen regulatory protein P-II; Region: P-II; smart00938 199310001477 ammonium transporter; Provisional; Region: PRK10666 199310001478 acyl-CoA thioesterase II; Provisional; Region: PRK10526 199310001479 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 199310001480 active site 199310001481 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 199310001482 catalytic triad [active] 199310001483 dimer interface [polypeptide binding]; other site 199310001484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 199310001485 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 199310001486 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 199310001487 DNA binding site [nucleotide binding] 199310001488 active site 199310001489 Uncharacterized conserved protein [Function unknown]; Region: COG5507 199310001490 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 199310001491 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 199310001492 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310001493 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 199310001494 maltose O-acetyltransferase; Provisional; Region: PRK10092 199310001495 Maltose acetyltransferase; Region: Mac; pfam12464 199310001496 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 199310001497 trimer interface [polypeptide binding]; other site 199310001498 active site 199310001499 substrate binding site [chemical binding]; other site 199310001500 CoA binding site [chemical binding]; other site 199310001501 gene expression modulator; Provisional; Region: PRK10945 199310001502 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 199310001503 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 199310001504 Protein export membrane protein; Region: SecD_SecF; cl14618 199310001505 Protein export membrane protein; Region: SecD_SecF; cl14618 199310001506 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 199310001507 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310001508 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310001509 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 199310001510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310001511 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 199310001512 hypothetical protein; Provisional; Region: PRK11281 199310001513 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 199310001514 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 199310001515 Mechanosensitive ion channel; Region: MS_channel; pfam00924 199310001516 hypothetical protein; Provisional; Region: PRK11038 199310001517 primosomal replication protein N''; Provisional; Region: PRK10093 199310001518 hypothetical protein; Provisional; Region: PRK10527 199310001519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310001520 active site 199310001521 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 199310001522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310001523 Walker A motif; other site 199310001524 ATP binding site [chemical binding]; other site 199310001525 Walker B motif; other site 199310001526 DNA polymerase III subunit delta'; Validated; Region: PRK08485 199310001527 arginine finger; other site 199310001528 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 199310001529 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 199310001530 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 199310001531 hypothetical protein; Validated; Region: PRK00153 199310001532 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 199310001533 RecR protein; Region: RecR; pfam02132 199310001534 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 199310001535 putative active site [active] 199310001536 putative metal-binding site [ion binding]; other site 199310001537 tetramer interface [polypeptide binding]; other site 199310001538 heat shock protein 90; Provisional; Region: PRK05218 199310001539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310001540 ATP binding site [chemical binding]; other site 199310001541 Mg2+ binding site [ion binding]; other site 199310001542 G-X-G motif; other site 199310001543 adenylate kinase; Reviewed; Region: adk; PRK00279 199310001544 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 199310001545 AMP-binding site [chemical binding]; other site 199310001546 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 199310001547 ferrochelatase; Region: hemH; TIGR00109 199310001548 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 199310001549 C-terminal domain interface [polypeptide binding]; other site 199310001550 active site 199310001551 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 199310001552 active site 199310001553 N-terminal domain interface [polypeptide binding]; other site 199310001554 acetyl esterase; Provisional; Region: PRK10162 199310001555 inosine/guanosine kinase; Provisional; Region: PRK15074 199310001556 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310001557 putative cation:proton antiport protein; Provisional; Region: PRK10669 199310001558 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 199310001559 TrkA-N domain; Region: TrkA_N; pfam02254 199310001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310001561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310001562 putative substrate translocation pore; other site 199310001563 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 199310001564 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 199310001565 active site 199310001566 metal binding site [ion binding]; metal-binding site 199310001567 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 199310001568 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 199310001569 putative deacylase active site [active] 199310001570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 199310001571 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 199310001572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310001573 non-specific DNA binding site [nucleotide binding]; other site 199310001574 salt bridge; other site 199310001575 sequence-specific DNA binding site [nucleotide binding]; other site 199310001576 copper exporting ATPase; Provisional; Region: copA; PRK10671 199310001577 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 199310001578 metal-binding site [ion binding] 199310001579 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 199310001580 metal-binding site [ion binding] 199310001581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 199310001582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310001583 motif II; other site 199310001584 glutaminase; Reviewed; Region: PRK12356 199310001585 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 199310001586 amino acid transporter; Region: 2A0306; TIGR00909 199310001587 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 199310001588 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 199310001589 DNA binding residues [nucleotide binding] 199310001590 dimer interface [polypeptide binding]; other site 199310001591 copper binding site [ion binding]; other site 199310001592 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 199310001593 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 199310001594 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 199310001595 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 199310001596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310001597 Walker A/P-loop; other site 199310001598 ATP binding site [chemical binding]; other site 199310001599 Q-loop/lid; other site 199310001600 ABC transporter signature motif; other site 199310001601 Walker B; other site 199310001602 D-loop; other site 199310001603 H-loop/switch region; other site 199310001604 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 199310001605 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 199310001606 oxidoreductase; Provisional; Region: PRK08017 199310001607 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 199310001608 NADP binding site [chemical binding]; other site 199310001609 active site 199310001610 steroid binding site; other site 199310001611 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 199310001612 active site 199310001613 catalytic triad [active] 199310001614 oxyanion hole [active] 199310001615 switch loop; other site 199310001616 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 199310001617 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 199310001618 Walker A/P-loop; other site 199310001619 ATP binding site [chemical binding]; other site 199310001620 Q-loop/lid; other site 199310001621 ABC transporter signature motif; other site 199310001622 Walker B; other site 199310001623 D-loop; other site 199310001624 H-loop/switch region; other site 199310001625 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 199310001626 FtsX-like permease family; Region: FtsX; pfam02687 199310001627 FtsX-like permease family; Region: FtsX; pfam02687 199310001628 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 199310001629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 199310001630 active site residue [active] 199310001631 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 199310001632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310001633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310001634 dimerization interface [polypeptide binding]; other site 199310001635 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 199310001636 ureidoglycolate hydrolase; Provisional; Region: PRK03606 199310001637 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 199310001638 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 199310001639 Bacterial transcriptional regulator; Region: IclR; pfam01614 199310001640 glyoxylate carboligase; Provisional; Region: PRK11269 199310001641 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 199310001642 PYR/PP interface [polypeptide binding]; other site 199310001643 dimer interface [polypeptide binding]; other site 199310001644 TPP binding site [chemical binding]; other site 199310001645 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 199310001646 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 199310001647 TPP-binding site [chemical binding]; other site 199310001648 hydroxypyruvate isomerase; Provisional; Region: PRK09997 199310001649 tartronate semialdehyde reductase; Provisional; Region: PRK15059 199310001650 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 199310001651 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 199310001652 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 199310001653 Na binding site [ion binding]; other site 199310001654 substrate binding site [chemical binding]; other site 199310001655 allantoinase; Provisional; Region: PRK08044 199310001656 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 199310001657 active site 199310001658 putative uracil/xanthine transporter; Provisional; Region: PRK11412 199310001659 glycerate kinase II; Provisional; Region: PRK09932 199310001660 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 199310001661 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 199310001662 Cupin domain; Region: Cupin_2; cl17218 199310001663 allantoate amidohydrolase; Region: AllC; TIGR03176 199310001664 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 199310001665 active site 199310001666 metal binding site [ion binding]; metal-binding site 199310001667 dimer interface [polypeptide binding]; other site 199310001668 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 199310001669 membrane protein FdrA; Validated; Region: PRK06091 199310001670 CoA binding domain; Region: CoA_binding; pfam02629 199310001671 CoA-ligase; Region: Ligase_CoA; pfam00549 199310001672 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 199310001673 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 199310001674 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 199310001675 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 199310001676 putative substrate binding site [chemical binding]; other site 199310001677 nucleotide binding site [chemical binding]; other site 199310001678 nucleotide binding site [chemical binding]; other site 199310001679 homodimer interface [polypeptide binding]; other site 199310001680 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 199310001681 ATP-grasp domain; Region: ATP-grasp; pfam02222 199310001682 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 199310001683 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 199310001684 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 199310001685 putative active site [active] 199310001686 putative metal binding site [ion binding]; other site 199310001687 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 199310001688 substrate binding site [chemical binding]; other site 199310001689 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 199310001690 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 199310001691 active site 199310001692 HIGH motif; other site 199310001693 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 199310001694 KMSKS motif; other site 199310001695 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 199310001696 tRNA binding surface [nucleotide binding]; other site 199310001697 anticodon binding site; other site 199310001698 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 199310001699 ribosome-associated protein; Provisional; Region: PRK11507 199310001700 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 199310001701 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 199310001702 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 199310001703 homodimer interface [polypeptide binding]; other site 199310001704 NADP binding site [chemical binding]; other site 199310001705 substrate binding site [chemical binding]; other site 199310001706 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 199310001707 Methyltransferase domain; Region: Methyltransf_12; pfam08242 199310001708 S-adenosylmethionine binding site [chemical binding]; other site 199310001709 outer membrane protease; Reviewed; Region: PRK10993 199310001710 hypothetical protein; Provisional; Region: PRK09936 199310001711 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 199310001712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310001713 TPR motif; other site 199310001714 binding surface 199310001715 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 199310001716 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 199310001717 active site 199310001718 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 199310001719 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 199310001720 sensor kinase CusS; Provisional; Region: PRK09835 199310001721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310001722 dimerization interface [polypeptide binding]; other site 199310001723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310001724 dimer interface [polypeptide binding]; other site 199310001725 phosphorylation site [posttranslational modification] 199310001726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310001727 ATP binding site [chemical binding]; other site 199310001728 Mg2+ binding site [ion binding]; other site 199310001729 G-X-G motif; other site 199310001730 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 199310001731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310001732 active site 199310001733 phosphorylation site [posttranslational modification] 199310001734 intermolecular recognition site; other site 199310001735 dimerization interface [polypeptide binding]; other site 199310001736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310001737 DNA binding site [nucleotide binding] 199310001738 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 199310001739 periplasmic copper-binding protein; Provisional; Region: PRK09838 199310001740 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 199310001741 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310001742 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 199310001743 phenylalanine transporter; Provisional; Region: PRK10249 199310001744 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 199310001745 Mechanosensitive ion channel; Region: MS_channel; pfam00924 199310001746 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 199310001747 dimer interface [polypeptide binding]; other site 199310001748 FMN binding site [chemical binding]; other site 199310001749 hypothetical protein; Provisional; Region: PRK10250 199310001750 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 199310001751 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 199310001752 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 199310001753 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 199310001754 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 199310001755 outer membrane receptor FepA; Provisional; Region: PRK13524 199310001756 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310001757 N-terminal plug; other site 199310001758 ligand-binding site [chemical binding]; other site 199310001759 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 199310001760 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 199310001761 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 199310001762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 199310001763 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 199310001764 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 199310001765 acyl-activating enzyme (AAE) consensus motif; other site 199310001766 AMP binding site [chemical binding]; other site 199310001767 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310001768 LPS O-antigen length regulator; Provisional; Region: PRK10381 199310001769 Chain length determinant protein; Region: Wzz; pfam02706 199310001770 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 199310001771 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310001772 Walker A/P-loop; other site 199310001773 ATP binding site [chemical binding]; other site 199310001774 Q-loop/lid; other site 199310001775 ABC transporter signature motif; other site 199310001776 Walker B; other site 199310001777 D-loop; other site 199310001778 H-loop/switch region; other site 199310001779 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 199310001780 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310001781 ABC-ATPase subunit interface; other site 199310001782 dimer interface [polypeptide binding]; other site 199310001783 putative PBP binding regions; other site 199310001784 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 199310001785 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310001786 ABC-ATPase subunit interface; other site 199310001787 dimer interface [polypeptide binding]; other site 199310001788 putative PBP binding regions; other site 199310001789 enterobactin exporter EntS; Provisional; Region: PRK10489 199310001790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310001791 putative substrate translocation pore; other site 199310001792 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 199310001793 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 199310001794 siderophore binding site; other site 199310001795 isochorismate synthase EntC; Provisional; Region: PRK15016 199310001796 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 199310001797 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 199310001798 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 199310001799 acyl-activating enzyme (AAE) consensus motif; other site 199310001800 active site 199310001801 AMP binding site [chemical binding]; other site 199310001802 substrate binding site [chemical binding]; other site 199310001803 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 199310001804 hydrophobic substrate binding pocket; other site 199310001805 Isochorismatase family; Region: Isochorismatase; pfam00857 199310001806 active site 199310001807 conserved cis-peptide bond; other site 199310001808 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 199310001809 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 199310001810 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 199310001811 putative NAD(P) binding site [chemical binding]; other site 199310001812 active site 199310001813 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 199310001814 CoenzymeA binding site [chemical binding]; other site 199310001815 subunit interaction site [polypeptide binding]; other site 199310001816 PHB binding site; other site 199310001817 carbon starvation protein A; Provisional; Region: PRK15015 199310001818 Carbon starvation protein CstA; Region: CstA; pfam02554 199310001819 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 199310001820 Uncharacterized small protein [Function unknown]; Region: COG2879 199310001821 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 199310001822 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 199310001823 putative active site [active] 199310001824 metal binding site [ion binding]; metal-binding site 199310001825 methionine aminotransferase; Validated; Region: PRK09082 199310001826 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310001827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310001828 homodimer interface [polypeptide binding]; other site 199310001829 catalytic residue [active] 199310001830 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 199310001831 ParB-like nuclease domain; Region: ParBc; pfam02195 199310001832 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 199310001833 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 199310001834 Active Sites [active] 199310001835 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 199310001836 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 199310001837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310001838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310001839 dimerization interface [polypeptide binding]; other site 199310001840 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 199310001841 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 199310001842 dimerization domain [polypeptide binding]; other site 199310001843 dimer interface [polypeptide binding]; other site 199310001844 catalytic residues [active] 199310001845 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 199310001846 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 199310001847 dimer interface [polypeptide binding]; other site 199310001848 decamer (pentamer of dimers) interface [polypeptide binding]; other site 199310001849 catalytic triad [active] 199310001850 peroxidatic and resolving cysteines [active] 199310001851 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 199310001852 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 199310001853 catalytic residue [active] 199310001854 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 199310001855 catalytic residues [active] 199310001856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310001857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310001858 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 199310001859 Ligand Binding Site [chemical binding]; other site 199310001860 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 199310001861 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 199310001862 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 199310001863 B1 nucleotide binding pocket [chemical binding]; other site 199310001864 B2 nucleotide binding pocket [chemical binding]; other site 199310001865 CAS motifs; other site 199310001866 active site 199310001867 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 199310001868 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 199310001869 transmembrane helices; other site 199310001870 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 199310001871 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 199310001872 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 199310001873 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 199310001874 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 199310001875 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 199310001876 putative active site [active] 199310001877 (T/H)XGH motif; other site 199310001878 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 199310001879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310001880 putative active site [active] 199310001881 heme pocket [chemical binding]; other site 199310001882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310001883 ATP binding site [chemical binding]; other site 199310001884 Mg2+ binding site [ion binding]; other site 199310001885 G-X-G motif; other site 199310001886 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 199310001887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310001888 active site 199310001889 phosphorylation site [posttranslational modification] 199310001890 intermolecular recognition site; other site 199310001891 dimerization interface [polypeptide binding]; other site 199310001892 Transcriptional regulator; Region: CitT; pfam12431 199310001893 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 199310001894 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 199310001895 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 199310001896 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310001897 DNA-binding site [nucleotide binding]; DNA binding site 199310001898 RNA-binding motif; other site 199310001899 chromosome condensation membrane protein; Provisional; Region: PRK14196 199310001900 Predicted amidohydrolase [General function prediction only]; Region: COG0388 199310001901 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 199310001902 putative active site [active] 199310001903 catalytic triad [active] 199310001904 putative dimer interface [polypeptide binding]; other site 199310001905 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 199310001906 lipoyl synthase; Provisional; Region: PRK05481 199310001907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310001908 FeS/SAM binding site; other site 199310001909 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 199310001910 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 199310001911 lipoate-protein ligase B; Provisional; Region: PRK14342 199310001912 hypothetical protein; Provisional; Region: PRK04998 199310001913 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 199310001914 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 199310001915 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 199310001916 rare lipoprotein A; Provisional; Region: PRK10672 199310001917 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 199310001918 Sporulation related domain; Region: SPOR; pfam05036 199310001919 cell wall shape-determining protein; Provisional; Region: PRK10794 199310001920 penicillin-binding protein 2; Provisional; Region: PRK10795 199310001921 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 199310001922 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 199310001923 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 199310001924 ribosome-associated protein; Provisional; Region: PRK11538 199310001925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 199310001926 catalytic core [active] 199310001927 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 199310001928 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 199310001929 active site 199310001930 (T/H)XGH motif; other site 199310001931 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 199310001932 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 199310001933 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 199310001934 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 199310001935 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 199310001936 HIGH motif; other site 199310001937 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 199310001938 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 199310001939 active site 199310001940 KMSKS motif; other site 199310001941 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 199310001942 tRNA binding surface [nucleotide binding]; other site 199310001943 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 199310001944 hypothetical protein; Provisional; Region: PRK11032 199310001945 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 199310001946 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 199310001947 active site 199310001948 tetramer interface [polypeptide binding]; other site 199310001949 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 199310001950 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 199310001951 Walker A/P-loop; other site 199310001952 ATP binding site [chemical binding]; other site 199310001953 Q-loop/lid; other site 199310001954 ABC transporter signature motif; other site 199310001955 Walker B; other site 199310001956 D-loop; other site 199310001957 H-loop/switch region; other site 199310001958 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 199310001959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310001960 dimer interface [polypeptide binding]; other site 199310001961 conserved gate region; other site 199310001962 putative PBP binding loops; other site 199310001963 ABC-ATPase subunit interface; other site 199310001964 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 199310001965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310001966 dimer interface [polypeptide binding]; other site 199310001967 conserved gate region; other site 199310001968 putative PBP binding loops; other site 199310001969 ABC-ATPase subunit interface; other site 199310001970 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 199310001971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310001972 substrate binding pocket [chemical binding]; other site 199310001973 membrane-bound complex binding site; other site 199310001974 hinge residues; other site 199310001975 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 199310001976 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 199310001977 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 199310001978 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 199310001979 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 199310001980 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 199310001981 putative active site [active] 199310001982 catalytic triad [active] 199310001983 putative dimer interface [polypeptide binding]; other site 199310001984 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 199310001985 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 199310001986 Transporter associated domain; Region: CorC_HlyC; smart01091 199310001987 metal-binding heat shock protein; Provisional; Region: PRK00016 199310001988 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 199310001989 PhoH-like protein; Region: PhoH; pfam02562 199310001990 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 199310001991 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 199310001992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310001993 FeS/SAM binding site; other site 199310001994 TRAM domain; Region: TRAM; pfam01938 199310001995 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 199310001996 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 199310001997 asparagine synthetase B; Provisional; Region: asnB; PRK09431 199310001998 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 199310001999 active site 199310002000 dimer interface [polypeptide binding]; other site 199310002001 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 199310002002 Ligand Binding Site [chemical binding]; other site 199310002003 Molecular Tunnel; other site 199310002004 UMP phosphatase; Provisional; Region: PRK10444 199310002005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002006 active site 199310002007 motif I; other site 199310002008 motif II; other site 199310002009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002010 MarR family; Region: MarR; pfam01047 199310002011 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 199310002012 ROK family; Region: ROK; pfam00480 199310002013 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 199310002014 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 199310002015 active site 199310002016 dimer interface [polypeptide binding]; other site 199310002017 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 199310002018 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 199310002019 active site 199310002020 trimer interface [polypeptide binding]; other site 199310002021 allosteric site; other site 199310002022 active site lid [active] 199310002023 hexamer (dimer of trimers) interface [polypeptide binding]; other site 199310002024 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 199310002025 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 199310002026 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310002027 active site turn [active] 199310002028 phosphorylation site [posttranslational modification] 199310002029 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 199310002030 HPr interaction site; other site 199310002031 glycerol kinase (GK) interaction site [polypeptide binding]; other site 199310002032 active site 199310002033 phosphorylation site [posttranslational modification] 199310002034 bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128 199310002035 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 199310002036 transmembrane helices; other site 199310002037 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 199310002038 Domain of unknown function (DUF386); Region: DUF386; cl01047 199310002039 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 199310002040 BNR repeat-like domain; Region: BNR_2; pfam13088 199310002041 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 199310002042 dihydrodipicolinate synthase; Region: dapA; TIGR00674 199310002043 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 199310002044 inhibitor site; inhibition site 199310002045 active site 199310002046 dimer interface [polypeptide binding]; other site 199310002047 catalytic residue [active] 199310002048 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 199310002049 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 199310002050 putative active site [active] 199310002051 metal binding site [ion binding]; metal-binding site 199310002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 199310002053 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 199310002054 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 199310002055 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310002056 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 199310002057 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310002058 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 199310002059 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 199310002060 active site 199310002061 HIGH motif; other site 199310002062 nucleotide binding site [chemical binding]; other site 199310002063 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 199310002064 KMSKS motif; other site 199310002065 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 199310002066 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310002067 outer membrane porin, OprD family; Region: OprD; pfam03573 199310002068 YbfN-like lipoprotein; Region: YbfN; pfam13982 199310002069 ferric uptake regulator; Provisional; Region: fur; PRK09462 199310002070 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 199310002071 metal binding site 2 [ion binding]; metal-binding site 199310002072 putative DNA binding helix; other site 199310002073 metal binding site 1 [ion binding]; metal-binding site 199310002074 dimer interface [polypeptide binding]; other site 199310002075 structural Zn2+ binding site [ion binding]; other site 199310002076 flavodoxin FldA; Validated; Region: PRK09267 199310002077 LexA regulated protein; Provisional; Region: PRK11675 199310002078 acyl-CoA esterase; Provisional; Region: PRK10673 199310002079 PGAP1-like protein; Region: PGAP1; pfam07819 199310002080 replication initiation regulator SeqA; Provisional; Region: PRK11187 199310002081 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 199310002082 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 199310002083 active site 199310002084 substrate binding site [chemical binding]; other site 199310002085 metal binding site [ion binding]; metal-binding site 199310002086 putrescine transporter; Provisional; Region: potE; PRK10655 199310002087 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 199310002088 ornithine decarboxylase; Provisional; Region: PRK13578 199310002089 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 199310002090 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 199310002091 homodimer interface [polypeptide binding]; other site 199310002092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310002093 catalytic residue [active] 199310002094 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 199310002095 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 199310002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310002097 active site 199310002098 phosphorylation site [posttranslational modification] 199310002099 intermolecular recognition site; other site 199310002100 dimerization interface [polypeptide binding]; other site 199310002101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310002102 DNA binding site [nucleotide binding] 199310002103 sensor protein KdpD; Provisional; Region: PRK10490 199310002104 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 199310002105 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 199310002106 Ligand Binding Site [chemical binding]; other site 199310002107 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 199310002108 GAF domain; Region: GAF_3; pfam13492 199310002109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310002110 dimer interface [polypeptide binding]; other site 199310002111 phosphorylation site [posttranslational modification] 199310002112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310002113 ATP binding site [chemical binding]; other site 199310002114 Mg2+ binding site [ion binding]; other site 199310002115 G-X-G motif; other site 199310002116 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 199310002117 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 199310002118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 199310002119 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 199310002120 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 199310002121 hypothetical protein; Provisional; Region: PRK10167 199310002122 Uncharacterized conserved protein [Function unknown]; Region: COG3272 199310002123 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 199310002124 DNA photolyase; Region: DNA_photolyase; pfam00875 199310002125 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 199310002126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310002127 putative substrate translocation pore; other site 199310002128 POT family; Region: PTR2; pfam00854 199310002129 Uncharacterized conserved protein [Function unknown]; Region: COG0327 199310002130 metal-binding protein; Provisional; Region: PRK10799 199310002131 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 199310002132 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 199310002133 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 199310002134 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 199310002135 putative active site [active] 199310002136 endonuclease VIII; Provisional; Region: PRK10445 199310002137 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 199310002138 DNA binding site [nucleotide binding] 199310002139 catalytic residue [active] 199310002140 putative catalytic residues [active] 199310002141 H2TH interface [polypeptide binding]; other site 199310002142 intercalation triad [nucleotide binding]; other site 199310002143 substrate specificity determining residue; other site 199310002144 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 199310002145 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 199310002146 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 199310002147 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 199310002148 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 199310002149 Fimbrial protein; Region: Fimbrial; cl01416 199310002150 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 199310002151 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 199310002152 dimer interface [polypeptide binding]; other site 199310002153 active site 199310002154 citrylCoA binding site [chemical binding]; other site 199310002155 NADH binding [chemical binding]; other site 199310002156 cationic pore residues; other site 199310002157 oxalacetate/citrate binding site [chemical binding]; other site 199310002158 coenzyme A binding site [chemical binding]; other site 199310002159 catalytic triad [active] 199310002160 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 199310002161 Iron-sulfur protein interface; other site 199310002162 proximal quinone binding site [chemical binding]; other site 199310002163 SdhD (CybS) interface [polypeptide binding]; other site 199310002164 proximal heme binding site [chemical binding]; other site 199310002165 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 199310002166 SdhC subunit interface [polypeptide binding]; other site 199310002167 proximal heme binding site [chemical binding]; other site 199310002168 cardiolipin binding site; other site 199310002169 Iron-sulfur protein interface; other site 199310002170 proximal quinone binding site [chemical binding]; other site 199310002171 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 199310002172 L-aspartate oxidase; Provisional; Region: PRK06175 199310002173 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 199310002174 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 199310002175 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 199310002176 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 199310002177 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 199310002178 TPP-binding site [chemical binding]; other site 199310002179 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 199310002180 dimer interface [polypeptide binding]; other site 199310002181 PYR/PP interface [polypeptide binding]; other site 199310002182 TPP binding site [chemical binding]; other site 199310002183 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 199310002184 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 199310002185 E3 interaction surface; other site 199310002186 lipoyl attachment site [posttranslational modification]; other site 199310002187 e3 binding domain; Region: E3_binding; pfam02817 199310002188 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 199310002189 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 199310002190 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 199310002191 CoA-ligase; Region: Ligase_CoA; pfam00549 199310002192 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 199310002193 CoA binding domain; Region: CoA_binding; smart00881 199310002194 CoA-ligase; Region: Ligase_CoA; pfam00549 199310002195 TPR repeat; Region: TPR_11; pfam13414 199310002196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310002197 binding surface 199310002198 TPR motif; other site 199310002199 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 199310002200 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 199310002201 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 199310002202 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 199310002203 hypothetical protein; Provisional; Region: PRK10588 199310002204 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 199310002205 active site 199310002206 colicin uptake protein TolQ; Provisional; Region: PRK10801 199310002207 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 199310002208 colicin uptake protein TolR; Provisional; Region: PRK11024 199310002209 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 199310002210 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 199310002211 TolA C-terminal; Region: TolA; pfam06519 199310002212 translocation protein TolB; Provisional; Region: tolB; PRK03629 199310002213 TolB amino-terminal domain; Region: TolB_N; pfam04052 199310002214 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 199310002215 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 199310002216 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 199310002217 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 199310002218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 199310002219 ligand binding site [chemical binding]; other site 199310002220 tol-pal system protein YbgF; Provisional; Region: PRK10803 199310002221 Tetratricopeptide repeat; Region: TPR_6; pfam13174 199310002222 quinolinate synthetase; Provisional; Region: PRK09375 199310002223 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 199310002224 Cation efflux family; Region: Cation_efflux; cl00316 199310002225 YbgS-like protein; Region: YbgS; pfam13985 199310002226 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 199310002227 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 199310002228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 199310002229 catalytic core [active] 199310002230 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 199310002231 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 199310002232 active site 199310002233 catalytic residues [active] 199310002234 galactokinase; Provisional; Region: PRK05101 199310002235 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 199310002236 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 199310002237 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 199310002238 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 199310002239 dimer interface [polypeptide binding]; other site 199310002240 active site 199310002241 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 199310002242 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 199310002243 NAD binding site [chemical binding]; other site 199310002244 homodimer interface [polypeptide binding]; other site 199310002245 active site 199310002246 substrate binding site [chemical binding]; other site 199310002247 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 199310002248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 199310002249 Walker A/P-loop; other site 199310002250 ATP binding site [chemical binding]; other site 199310002251 Q-loop/lid; other site 199310002252 ABC transporter signature motif; other site 199310002253 Walker B; other site 199310002254 D-loop; other site 199310002255 H-loop/switch region; other site 199310002256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310002257 Walker A/P-loop; other site 199310002258 ATP binding site [chemical binding]; other site 199310002259 Q-loop/lid; other site 199310002260 ABC transporter signature motif; other site 199310002261 Walker B; other site 199310002262 D-loop; other site 199310002263 H-loop/switch region; other site 199310002264 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 199310002265 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 199310002266 molybdenum-pterin binding domain; Region: Mop; TIGR00638 199310002267 TOBE domain; Region: TOBE; pfam03459 199310002268 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 199310002269 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 199310002270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310002271 substrate binding pocket [chemical binding]; other site 199310002272 membrane-bound complex binding site; other site 199310002273 hinge residues; other site 199310002274 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 199310002275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002276 dimer interface [polypeptide binding]; other site 199310002277 conserved gate region; other site 199310002278 putative PBP binding loops; other site 199310002279 ABC-ATPase subunit interface; other site 199310002280 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 199310002281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310002282 Walker A/P-loop; other site 199310002283 ATP binding site [chemical binding]; other site 199310002284 Q-loop/lid; other site 199310002285 ABC transporter signature motif; other site 199310002286 Walker B; other site 199310002287 D-loop; other site 199310002288 H-loop/switch region; other site 199310002289 molybdenum-pterin binding domain; Region: Mop; TIGR00638 199310002290 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 199310002291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002292 motif II; other site 199310002293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002294 6-phosphogluconolactonase; Provisional; Region: PRK11028 199310002295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310002296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310002297 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 199310002298 putative dimerization interface [polypeptide binding]; other site 199310002299 PrpF protein; Region: PrpF; pfam04303 199310002300 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 199310002301 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 199310002302 transmembrane helices; other site 199310002303 putative hydratase; Provisional; Region: PRK11413 199310002304 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 199310002305 substrate binding site [chemical binding]; other site 199310002306 ligand binding site [chemical binding]; other site 199310002307 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 199310002308 substrate binding site [chemical binding]; other site 199310002309 acyl-CoA thioesterase; Provisional; Region: PRK10531 199310002310 putative pectinesterase; Region: PLN02432; cl01911 199310002311 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 199310002312 substrate binding site [chemical binding]; other site 199310002313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 199310002314 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 199310002315 Probable transposase; Region: OrfB_IS605; pfam01385 199310002316 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 199310002317 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 199310002318 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 199310002319 inhibitor-cofactor binding pocket; inhibition site 199310002320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310002321 catalytic residue [active] 199310002322 biotin synthase; Provisional; Region: PRK15108 199310002323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310002324 FeS/SAM binding site; other site 199310002325 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 199310002326 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 199310002327 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 199310002328 substrate-cofactor binding pocket; other site 199310002329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310002330 catalytic residue [active] 199310002331 AAA domain; Region: AAA_26; pfam13500 199310002332 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 199310002333 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 199310002334 ADP binding site [chemical binding]; other site 199310002335 excinuclease ABC subunit B; Provisional; Region: PRK05298 199310002336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310002337 ATP binding site [chemical binding]; other site 199310002338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310002339 nucleotide binding region [chemical binding]; other site 199310002340 ATP-binding site [chemical binding]; other site 199310002341 Ultra-violet resistance protein B; Region: UvrB; pfam12344 199310002342 UvrB/uvrC motif; Region: UVR; pfam02151 199310002343 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 199310002344 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 199310002345 putative substrate binding pocket [chemical binding]; other site 199310002346 dimer interface [polypeptide binding]; other site 199310002347 phosphate binding site [ion binding]; other site 199310002348 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 199310002349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310002350 FeS/SAM binding site; other site 199310002351 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 199310002352 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 199310002353 MPT binding site; other site 199310002354 trimer interface [polypeptide binding]; other site 199310002355 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 199310002356 trimer interface [polypeptide binding]; other site 199310002357 dimer interface [polypeptide binding]; other site 199310002358 putative active site [active] 199310002359 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 199310002360 MoaE interaction surface [polypeptide binding]; other site 199310002361 MoeB interaction surface [polypeptide binding]; other site 199310002362 thiocarboxylated glycine; other site 199310002363 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 199310002364 MoaE homodimer interface [polypeptide binding]; other site 199310002365 MoaD interaction [polypeptide binding]; other site 199310002366 active site residues [active] 199310002367 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 199310002368 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 199310002369 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 199310002370 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 199310002371 Predicted integral membrane protein [Function unknown]; Region: COG0392 199310002372 cardiolipin synthase 2; Provisional; Region: PRK11263 199310002373 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 199310002374 putative active site [active] 199310002375 catalytic site [active] 199310002376 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 199310002377 putative active site [active] 199310002378 catalytic site [active] 199310002379 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 199310002380 putative catalytic site [active] 199310002381 putative metal binding site [ion binding]; other site 199310002382 putative phosphate binding site [ion binding]; other site 199310002383 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 199310002384 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 199310002385 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 199310002386 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 199310002387 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 199310002388 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 199310002389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 199310002390 Walker A/P-loop; other site 199310002391 ATP binding site [chemical binding]; other site 199310002392 Q-loop/lid; other site 199310002393 ABC transporter signature motif; other site 199310002394 Walker B; other site 199310002395 D-loop; other site 199310002396 H-loop/switch region; other site 199310002397 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 199310002398 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 199310002399 Walker A/P-loop; other site 199310002400 ATP binding site [chemical binding]; other site 199310002401 Q-loop/lid; other site 199310002402 ABC transporter signature motif; other site 199310002403 Walker B; other site 199310002404 D-loop; other site 199310002405 H-loop/switch region; other site 199310002406 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 199310002407 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310002408 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310002409 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 199310002410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310002411 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 199310002412 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 199310002413 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 199310002414 ATP binding site [chemical binding]; other site 199310002415 Mg++ binding site [ion binding]; other site 199310002416 motif III; other site 199310002417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310002418 nucleotide binding region [chemical binding]; other site 199310002419 ATP-binding site [chemical binding]; other site 199310002420 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 199310002421 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 199310002422 DEAD_2; Region: DEAD_2; pfam06733 199310002423 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 199310002424 glycosyl transferase family protein; Provisional; Region: PRK08136 199310002425 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 199310002426 putative dehydrogenase; Provisional; Region: PRK10098 199310002427 hypothetical protein; Provisional; Region: PRK10259 199310002428 hypothetical protein; Provisional; Region: PRK11019 199310002429 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 199310002430 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 199310002431 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310002432 N-terminal plug; other site 199310002433 ligand-binding site [chemical binding]; other site 199310002434 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 199310002435 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 199310002436 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 199310002437 putative mechanosensitive channel protein; Provisional; Region: PRK11465 199310002438 Mechanosensitive ion channel; Region: MS_channel; pfam00924 199310002439 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 199310002440 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 199310002441 Walker A/P-loop; other site 199310002442 ATP binding site [chemical binding]; other site 199310002443 Q-loop/lid; other site 199310002444 ABC transporter signature motif; other site 199310002445 Walker B; other site 199310002446 D-loop; other site 199310002447 H-loop/switch region; other site 199310002448 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 199310002449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002450 dimer interface [polypeptide binding]; other site 199310002451 conserved gate region; other site 199310002452 putative PBP binding loops; other site 199310002453 ABC-ATPase subunit interface; other site 199310002454 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 199310002455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310002456 substrate binding pocket [chemical binding]; other site 199310002457 membrane-bound complex binding site; other site 199310002458 hinge residues; other site 199310002459 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 199310002460 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 199310002461 dimerization interface [polypeptide binding]; other site 199310002462 DPS ferroxidase diiron center [ion binding]; other site 199310002463 ion pore; other site 199310002464 threonine and homoserine efflux system; Provisional; Region: PRK10532 199310002465 EamA-like transporter family; Region: EamA; pfam00892 199310002466 outer membrane protein X; Provisional; Region: ompX; PRK09408 199310002467 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 199310002468 Sulfatase; Region: Sulfatase; pfam00884 199310002469 manganese transport regulator MntR; Provisional; Region: PRK11050 199310002470 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 199310002471 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 199310002472 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 199310002473 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 199310002474 transmembrane helices; other site 199310002475 L,D-transpeptidase; Provisional; Region: PRK10260 199310002476 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 199310002477 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 199310002478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310002479 Walker A/P-loop; other site 199310002480 ATP binding site [chemical binding]; other site 199310002481 Q-loop/lid; other site 199310002482 ABC transporter signature motif; other site 199310002483 Walker B; other site 199310002484 D-loop; other site 199310002485 H-loop/switch region; other site 199310002486 ABC transporter; Region: ABC_tran_2; pfam12848 199310002487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 199310002488 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 199310002489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002490 active site 199310002491 motif I; other site 199310002492 motif II; other site 199310002493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002494 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 199310002495 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 199310002496 dimer interface [polypeptide binding]; other site 199310002497 active site 199310002498 glycine loop; other site 199310002499 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 199310002500 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 199310002501 active site 199310002502 intersubunit interactions; other site 199310002503 catalytic residue [active] 199310002504 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 199310002505 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 199310002506 ATP binding site [chemical binding]; other site 199310002507 substrate interface [chemical binding]; other site 199310002508 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 199310002509 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 199310002510 dimer interface [polypeptide binding]; other site 199310002511 putative functional site; other site 199310002512 putative MPT binding site; other site 199310002513 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 199310002514 catalytic nucleophile [active] 199310002515 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 199310002516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310002517 Walker A/P-loop; other site 199310002518 ATP binding site [chemical binding]; other site 199310002519 Q-loop/lid; other site 199310002520 ABC transporter signature motif; other site 199310002521 Walker B; other site 199310002522 D-loop; other site 199310002523 H-loop/switch region; other site 199310002524 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 199310002525 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310002526 Walker A/P-loop; other site 199310002527 ATP binding site [chemical binding]; other site 199310002528 Q-loop/lid; other site 199310002529 ABC transporter signature motif; other site 199310002530 Walker B; other site 199310002531 D-loop; other site 199310002532 H-loop/switch region; other site 199310002533 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 199310002534 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 199310002535 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 199310002536 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 199310002537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002538 dimer interface [polypeptide binding]; other site 199310002539 conserved gate region; other site 199310002540 putative PBP binding loops; other site 199310002541 ABC-ATPase subunit interface; other site 199310002542 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 199310002543 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 199310002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002545 dimer interface [polypeptide binding]; other site 199310002546 conserved gate region; other site 199310002547 putative PBP binding loops; other site 199310002548 ABC-ATPase subunit interface; other site 199310002549 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310002550 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310002551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310002552 metal binding site [ion binding]; metal-binding site 199310002553 active site 199310002554 I-site; other site 199310002555 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 199310002556 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 199310002557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310002558 FeS/SAM binding site; other site 199310002559 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 199310002560 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 199310002561 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 199310002562 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 199310002563 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 199310002564 putative C-terminal domain interface [polypeptide binding]; other site 199310002565 putative GSH binding site (G-site) [chemical binding]; other site 199310002566 putative dimer interface [polypeptide binding]; other site 199310002567 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 199310002568 N-terminal domain interface [polypeptide binding]; other site 199310002569 dimer interface [polypeptide binding]; other site 199310002570 substrate binding pocket (H-site) [chemical binding]; other site 199310002571 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 199310002572 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 199310002573 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 199310002574 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 199310002575 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 199310002576 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310002577 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 199310002578 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 199310002579 active site 199310002580 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 199310002581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310002582 putative substrate translocation pore; other site 199310002583 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 199310002584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002585 active site 199310002586 motif I; other site 199310002587 motif II; other site 199310002588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310002589 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 199310002590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310002591 putative substrate translocation pore; other site 199310002592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310002593 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 199310002594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310002595 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 199310002596 integrase; Provisional; Region: int; PHA02601 199310002597 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310002598 active site 199310002599 DNA binding site [nucleotide binding] 199310002600 Int/Topo IB signature motif; other site 199310002601 Bacitracin resistance protein BacA; Region: BacA; cl00858 199310002602 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 199310002603 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 199310002604 Helix-turn-helix domain; Region: HTH_17; cl17695 199310002605 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 199310002606 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 199310002607 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 199310002608 DksA-like zinc finger domain containing protein; Region: PHA00080 199310002609 DNA adenine methylase (dam); Region: dam; TIGR00571 199310002610 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 199310002611 DinI-like family; Region: DinI; pfam06183 199310002612 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 199310002613 portal vertex protein; Provisional; Region: Q; PHA02536 199310002614 Phage portal protein; Region: Phage_portal; pfam04860 199310002615 terminase ATPase subunit; Provisional; Region: P; PHA02535 199310002616 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 199310002617 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 199310002618 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 199310002619 capsid protein; Provisional; Region: N; PHA02538 199310002620 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 199310002621 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 199310002622 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 199310002623 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 199310002624 catalytic residues [active] 199310002625 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 199310002626 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 199310002627 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 199310002628 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 199310002629 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 199310002630 baseplate wedge subunit; Provisional; Region: W; PHA02516 199310002631 baseplate assembly protein; Provisional; Region: J; PHA02568 199310002632 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 199310002633 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 199310002634 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 199310002635 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 199310002636 Acyltransferase family; Region: Acyl_transf_3; pfam01757 199310002637 major tail sheath protein; Provisional; Region: FI; PHA02560 199310002638 major tail tube protein; Provisional; Region: FII; PHA02600 199310002639 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 199310002640 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 199310002641 Phage protein U [General function prediction only]; Region: COG3499 199310002642 tail protein; Provisional; Region: D; PHA02561 199310002643 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 199310002644 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 199310002645 putative transporter; Provisional; Region: PRK04972 199310002646 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 199310002647 TrkA-C domain; Region: TrkA_C; pfam02080 199310002648 TrkA-C domain; Region: TrkA_C; pfam02080 199310002649 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 199310002650 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 199310002651 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 199310002652 GSH binding site [chemical binding]; other site 199310002653 catalytic residues [active] 199310002654 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 199310002655 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 199310002656 dimer interface [polypeptide binding]; other site 199310002657 FMN binding site [chemical binding]; other site 199310002658 NADPH bind site [chemical binding]; other site 199310002659 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 199310002660 RimK-like ATP-grasp domain; Region: RimK; pfam08443 199310002661 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 199310002662 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 199310002663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 199310002664 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 199310002665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310002666 Walker A/P-loop; other site 199310002667 ATP binding site [chemical binding]; other site 199310002668 Q-loop/lid; other site 199310002669 ABC transporter signature motif; other site 199310002670 Walker B; other site 199310002671 D-loop; other site 199310002672 H-loop/switch region; other site 199310002673 TOBE domain; Region: TOBE_2; pfam08402 199310002674 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 199310002675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002676 dimer interface [polypeptide binding]; other site 199310002677 conserved gate region; other site 199310002678 putative PBP binding loops; other site 199310002679 ABC-ATPase subunit interface; other site 199310002680 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 199310002681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002682 dimer interface [polypeptide binding]; other site 199310002683 conserved gate region; other site 199310002684 putative PBP binding loops; other site 199310002685 ABC-ATPase subunit interface; other site 199310002686 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 199310002687 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 199310002688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310002689 S-adenosylmethionine binding site [chemical binding]; other site 199310002690 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 199310002691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310002692 substrate binding pocket [chemical binding]; other site 199310002693 membrane-bound complex binding site; other site 199310002694 hinge residues; other site 199310002695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002696 dimer interface [polypeptide binding]; other site 199310002697 conserved gate region; other site 199310002698 putative PBP binding loops; other site 199310002699 ABC-ATPase subunit interface; other site 199310002700 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 199310002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002702 dimer interface [polypeptide binding]; other site 199310002703 conserved gate region; other site 199310002704 putative PBP binding loops; other site 199310002705 ABC-ATPase subunit interface; other site 199310002706 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 199310002707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310002708 substrate binding pocket [chemical binding]; other site 199310002709 membrane-bound complex binding site; other site 199310002710 hinge residues; other site 199310002711 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 199310002712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310002713 Walker A/P-loop; other site 199310002714 ATP binding site [chemical binding]; other site 199310002715 Q-loop/lid; other site 199310002716 ABC transporter signature motif; other site 199310002717 Walker B; other site 199310002718 D-loop; other site 199310002719 H-loop/switch region; other site 199310002720 putative lipoprotein; Provisional; Region: PRK10533 199310002721 hypothetical protein; Provisional; Region: PRK02877 199310002722 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 199310002723 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 199310002724 amidase catalytic site [active] 199310002725 Zn binding residues [ion binding]; other site 199310002726 substrate binding site [chemical binding]; other site 199310002727 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 199310002728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 199310002729 NAD(P) binding site [chemical binding]; other site 199310002730 active site 199310002731 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 199310002732 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 199310002733 putative NAD(P) binding site [chemical binding]; other site 199310002734 putative active site [active] 199310002735 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 199310002736 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 199310002737 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 199310002738 tetramer interface [polypeptide binding]; other site 199310002739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310002740 catalytic residue [active] 199310002741 pyruvate dehydrogenase; Provisional; Region: PRK09124 199310002742 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 199310002743 PYR/PP interface [polypeptide binding]; other site 199310002744 dimer interface [polypeptide binding]; other site 199310002745 tetramer interface [polypeptide binding]; other site 199310002746 TPP binding site [chemical binding]; other site 199310002747 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 199310002748 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 199310002749 TPP-binding site [chemical binding]; other site 199310002750 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 199310002751 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 199310002752 FAD binding pocket [chemical binding]; other site 199310002753 FAD binding motif [chemical binding]; other site 199310002754 phosphate binding motif [ion binding]; other site 199310002755 beta-alpha-beta structure motif; other site 199310002756 NAD binding pocket [chemical binding]; other site 199310002757 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 199310002758 catalytic loop [active] 199310002759 iron binding site [ion binding]; other site 199310002760 hybrid cluster protein; Provisional; Region: PRK05290 199310002761 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 199310002762 ACS interaction site; other site 199310002763 CODH interaction site; other site 199310002764 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 199310002765 hybrid metal cluster; other site 199310002766 Predicted membrane protein [Function unknown]; Region: COG2431 199310002767 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 199310002768 amphipathic channel; other site 199310002769 Asn-Pro-Ala signature motifs; other site 199310002770 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 199310002771 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 199310002772 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 199310002773 putative active site [active] 199310002774 putative metal-binding site [ion binding]; other site 199310002775 Protein of unknown function (DUF535); Region: DUF535; pfam04393 199310002776 macrolide transporter subunit MacA; Provisional; Region: PRK11578 199310002777 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310002778 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310002779 FtsX-like permease family; Region: FtsX; pfam02687 199310002780 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310002781 DNA-binding site [nucleotide binding]; DNA binding site 199310002782 RNA-binding motif; other site 199310002783 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 199310002784 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 199310002785 Clp amino terminal domain; Region: Clp_N; pfam02861 199310002786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310002787 Walker A motif; other site 199310002788 ATP binding site [chemical binding]; other site 199310002789 Walker B motif; other site 199310002790 arginine finger; other site 199310002791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310002792 Walker A motif; other site 199310002793 ATP binding site [chemical binding]; other site 199310002794 Walker B motif; other site 199310002795 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 199310002796 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 199310002797 rRNA binding site [nucleotide binding]; other site 199310002798 predicted 30S ribosome binding site; other site 199310002799 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 199310002800 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 199310002801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310002802 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 199310002803 Walker A/P-loop; other site 199310002804 ATP binding site [chemical binding]; other site 199310002805 Q-loop/lid; other site 199310002806 ABC transporter signature motif; other site 199310002807 Walker B; other site 199310002808 D-loop; other site 199310002809 H-loop/switch region; other site 199310002810 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 199310002811 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310002812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310002813 Walker A/P-loop; other site 199310002814 ATP binding site [chemical binding]; other site 199310002815 Q-loop/lid; other site 199310002816 ABC transporter signature motif; other site 199310002817 Walker B; other site 199310002818 D-loop; other site 199310002819 H-loop/switch region; other site 199310002820 thioredoxin reductase; Provisional; Region: PRK10262 199310002821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310002822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310002823 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 199310002824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 199310002825 putative DNA binding site [nucleotide binding]; other site 199310002826 putative Zn2+ binding site [ion binding]; other site 199310002827 AsnC family; Region: AsnC_trans_reg; pfam01037 199310002828 DNA translocase FtsK; Provisional; Region: PRK10263 199310002829 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 199310002830 DNA translocase FtsK; Provisional; Region: PRK10263 199310002831 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 199310002832 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 199310002833 periplasmic chaperone LolA; Region: lolA; TIGR00547 199310002834 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 199310002835 recombination factor protein RarA; Reviewed; Region: PRK13342 199310002836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310002837 Walker A motif; other site 199310002838 ATP binding site [chemical binding]; other site 199310002839 Walker B motif; other site 199310002840 arginine finger; other site 199310002841 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 199310002842 seryl-tRNA synthetase; Provisional; Region: PRK05431 199310002843 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 199310002844 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 199310002845 dimer interface [polypeptide binding]; other site 199310002846 active site 199310002847 motif 1; other site 199310002848 motif 2; other site 199310002849 motif 3; other site 199310002850 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 199310002851 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 199310002852 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 199310002853 putative [Fe4-S4] binding site [ion binding]; other site 199310002854 putative molybdopterin cofactor binding site [chemical binding]; other site 199310002855 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 199310002856 putative molybdopterin cofactor binding site; other site 199310002857 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 199310002858 4Fe-4S binding domain; Region: Fer4; pfam00037 199310002859 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 199310002860 Isochorismatase family; Region: Isochorismatase; pfam00857 199310002861 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 199310002862 catalytic triad [active] 199310002863 dimer interface [polypeptide binding]; other site 199310002864 conserved cis-peptide bond; other site 199310002865 putative MFS family transporter protein; Provisional; Region: PRK03633 199310002866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310002867 putative substrate translocation pore; other site 199310002868 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 199310002869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310002870 FeS/SAM binding site; other site 199310002871 formate transporter; Provisional; Region: PRK10805 199310002872 uncharacterized domain; Region: TIGR00702 199310002873 YcaO-like family; Region: YcaO; pfam02624 199310002874 Predicted membrane protein [Function unknown]; Region: COG2323 199310002875 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 199310002876 homodimer interface [polypeptide binding]; other site 199310002877 substrate-cofactor binding pocket; other site 199310002878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310002879 catalytic residue [active] 199310002880 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 199310002881 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 199310002882 hinge; other site 199310002883 active site 199310002884 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 199310002885 cytidylate kinase; Provisional; Region: cmk; PRK00023 199310002886 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 199310002887 CMP-binding site; other site 199310002888 The sites determining sugar specificity; other site 199310002889 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 199310002890 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 199310002891 RNA binding site [nucleotide binding]; other site 199310002892 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 199310002893 RNA binding site [nucleotide binding]; other site 199310002894 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 199310002895 RNA binding site [nucleotide binding]; other site 199310002896 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 199310002897 RNA binding site [nucleotide binding]; other site 199310002898 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 199310002899 RNA binding site [nucleotide binding]; other site 199310002900 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 199310002901 IHF dimer interface [polypeptide binding]; other site 199310002902 IHF - DNA interface [nucleotide binding]; other site 199310002903 ComEC family competence protein; Provisional; Region: PRK11539 199310002904 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 199310002905 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 199310002906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 199310002907 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 199310002908 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310002909 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 199310002910 Walker A/P-loop; other site 199310002911 ATP binding site [chemical binding]; other site 199310002912 Q-loop/lid; other site 199310002913 ABC transporter signature motif; other site 199310002914 Walker B; other site 199310002915 D-loop; other site 199310002916 H-loop/switch region; other site 199310002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 199310002918 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 199310002919 hypothetical protein; Provisional; Region: PRK11827 199310002920 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 199310002921 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 199310002922 Ligand binding site; other site 199310002923 oligomer interface; other site 199310002924 hypothetical protein; Provisional; Region: PRK10593 199310002925 Uncharacterized conserved protein [Function unknown]; Region: COG1434 199310002926 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 199310002927 putative active site [active] 199310002928 Methyltransferase domain; Region: Methyltransf_31; pfam13847 199310002929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310002930 S-adenosylmethionine binding site [chemical binding]; other site 199310002931 condesin subunit F; Provisional; Region: PRK05260 199310002932 condesin subunit E; Provisional; Region: PRK05256 199310002933 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 199310002934 MukB N-terminal; Region: MukB; pfam04310 199310002935 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 199310002936 murein L,D-transpeptidase; Provisional; Region: PRK10594 199310002937 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 199310002938 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 199310002939 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 199310002940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 199310002941 Peptidase M15; Region: Peptidase_M15_3; cl01194 199310002942 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 199310002943 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 199310002944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310002945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310002946 homodimer interface [polypeptide binding]; other site 199310002947 catalytic residue [active] 199310002948 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 199310002949 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 199310002950 trimer interface [polypeptide binding]; other site 199310002951 eyelet of channel; other site 199310002952 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 199310002953 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 199310002954 putative dimer interface [polypeptide binding]; other site 199310002955 putative anticodon binding site; other site 199310002956 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 199310002957 homodimer interface [polypeptide binding]; other site 199310002958 motif 1; other site 199310002959 motif 2; other site 199310002960 active site 199310002961 motif 3; other site 199310002962 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 199310002963 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 199310002964 active site 199310002965 aminopeptidase N; Provisional; Region: pepN; PRK14015 199310002966 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 199310002967 active site 199310002968 Zn binding site [ion binding]; other site 199310002969 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 199310002970 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 199310002971 Walker A/P-loop; other site 199310002972 ATP binding site [chemical binding]; other site 199310002973 Q-loop/lid; other site 199310002974 ABC transporter signature motif; other site 199310002975 Walker B; other site 199310002976 D-loop; other site 199310002977 H-loop/switch region; other site 199310002978 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 199310002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310002980 dimer interface [polypeptide binding]; other site 199310002981 conserved gate region; other site 199310002982 putative PBP binding loops; other site 199310002983 ABC-ATPase subunit interface; other site 199310002984 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 199310002985 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 199310002986 active site 199310002987 dimer interface [polypeptide binding]; other site 199310002988 non-prolyl cis peptide bond; other site 199310002989 insertion regions; other site 199310002990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310002991 substrate binding pocket [chemical binding]; other site 199310002992 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 199310002993 membrane-bound complex binding site; other site 199310002994 hinge residues; other site 199310002995 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 199310002996 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 199310002997 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 199310002998 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 199310002999 quinone interaction residues [chemical binding]; other site 199310003000 active site 199310003001 catalytic residues [active] 199310003002 FMN binding site [chemical binding]; other site 199310003003 substrate binding site [chemical binding]; other site 199310003004 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 199310003005 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 199310003006 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 199310003007 MOSC domain; Region: MOSC; pfam03473 199310003008 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 199310003009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 199310003010 catalytic loop [active] 199310003011 iron binding site [ion binding]; other site 199310003012 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 199310003013 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 199310003014 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 199310003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310003016 S-adenosylmethionine binding site [chemical binding]; other site 199310003017 ABC transporter ATPase component; Reviewed; Region: PRK11147 199310003018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310003020 Walker A/P-loop; other site 199310003021 Walker A/P-loop; other site 199310003022 ATP binding site [chemical binding]; other site 199310003023 ATP binding site [chemical binding]; other site 199310003024 Q-loop/lid; other site 199310003025 Q-loop/lid; other site 199310003026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 199310003027 ABC transporter signature motif; other site 199310003028 Walker B; other site 199310003029 D-loop; other site 199310003030 ABC transporter; Region: ABC_tran_2; pfam12848 199310003031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 199310003032 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 199310003033 Paraquat-inducible protein A; Region: PqiA; pfam04403 199310003034 Paraquat-inducible protein A; Region: PqiA; pfam04403 199310003035 paraquat-inducible protein B; Provisional; Region: PRK10807 199310003036 mce related protein; Region: MCE; pfam02470 199310003037 mce related protein; Region: MCE; pfam02470 199310003038 mce related protein; Region: MCE; pfam02470 199310003039 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 199310003040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 199310003041 Protein of unknown function (DUF330); Region: DUF330; pfam03886 199310003042 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 199310003043 active site 1 [active] 199310003044 dimer interface [polypeptide binding]; other site 199310003045 active site 2 [active] 199310003046 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 199310003047 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 199310003048 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 199310003049 outer membrane protein A; Reviewed; Region: PRK10808 199310003050 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 199310003051 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 199310003052 ligand binding site [chemical binding]; other site 199310003053 SOS cell division inhibitor; Provisional; Region: PRK10595 199310003054 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 199310003055 TfoX C-terminal domain; Region: TfoX_C; pfam04994 199310003056 TIGR01666 family membrane protein; Region: YCCS 199310003057 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 199310003058 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 199310003059 Predicted membrane protein [Function unknown]; Region: COG3304 199310003060 Domain of unknown function (DUF307); Region: DUF307; pfam03733 199310003061 Domain of unknown function (DUF307); Region: DUF307; pfam03733 199310003062 DNA helicase IV; Provisional; Region: helD; PRK11054 199310003063 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 199310003064 Part of AAA domain; Region: AAA_19; pfam13245 199310003065 Family description; Region: UvrD_C_2; pfam13538 199310003066 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 199310003067 active site 199310003068 dimer interfaces [polypeptide binding]; other site 199310003069 catalytic residues [active] 199310003070 hypothetical protein; Provisional; Region: PRK03641 199310003071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 199310003072 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 199310003073 heat shock protein HspQ; Provisional; Region: PRK14129 199310003074 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 199310003075 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 199310003076 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 199310003077 putative RNA binding site [nucleotide binding]; other site 199310003078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310003079 S-adenosylmethionine binding site [chemical binding]; other site 199310003080 acylphosphatase; Provisional; Region: PRK14439 199310003081 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 199310003082 sulfur transfer protein TusE; Provisional; Region: PRK11508 199310003083 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 199310003084 YccA-like proteins; Region: YccA_like; cd10433 199310003085 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 199310003086 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 199310003087 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 199310003088 hydrogenase 1 large subunit; Provisional; Region: PRK10170 199310003089 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 199310003090 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 199310003091 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 199310003092 putative substrate-binding site; other site 199310003093 nickel binding site [ion binding]; other site 199310003094 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 199310003095 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 199310003096 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 199310003097 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 199310003098 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 199310003099 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 199310003100 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 199310003101 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 199310003102 catalytic core [active] 199310003103 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 199310003104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310003105 DNA-binding site [nucleotide binding]; DNA binding site 199310003106 RNA-binding motif; other site 199310003107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310003108 DNA-binding site [nucleotide binding]; DNA binding site 199310003109 RNA-binding motif; other site 199310003110 cold shock gene; Provisional; Region: PRK09891 199310003111 GnsA/GnsB family; Region: GnsAB; pfam08178 199310003112 4Fe-4S binding domain; Region: Fer4_5; pfam12801 199310003113 4Fe-4S binding domain; Region: Fer4_5; pfam12801 199310003114 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 199310003115 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 199310003116 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 199310003117 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 199310003118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 199310003119 dimerization interface [polypeptide binding]; other site 199310003120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310003121 dimer interface [polypeptide binding]; other site 199310003122 phosphorylation site [posttranslational modification] 199310003123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310003124 ATP binding site [chemical binding]; other site 199310003125 Mg2+ binding site [ion binding]; other site 199310003126 G-X-G motif; other site 199310003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310003128 active site 199310003129 phosphorylation site [posttranslational modification] 199310003130 intermolecular recognition site; other site 199310003131 dimerization interface [polypeptide binding]; other site 199310003132 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 199310003133 putative binding surface; other site 199310003134 active site 199310003135 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 199310003136 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 199310003137 putative ligand binding site [chemical binding]; other site 199310003138 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 199310003139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310003140 active site 199310003141 phosphorylation site [posttranslational modification] 199310003142 intermolecular recognition site; other site 199310003143 dimerization interface [polypeptide binding]; other site 199310003144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310003145 DNA binding site [nucleotide binding] 199310003146 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 199310003147 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 199310003148 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 199310003149 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 199310003150 molybdopterin cofactor binding site [chemical binding]; other site 199310003151 substrate binding site [chemical binding]; other site 199310003152 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 199310003153 molybdopterin cofactor binding site; other site 199310003154 chaperone protein TorD; Validated; Region: torD; PRK04976 199310003155 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 199310003156 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 199310003157 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 199310003158 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 199310003159 HSP70 interaction site [polypeptide binding]; other site 199310003160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 199310003161 substrate binding site [polypeptide binding]; other site 199310003162 dimer interface [polypeptide binding]; other site 199310003163 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 199310003164 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 199310003165 catalytic core [active] 199310003166 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 199310003167 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 199310003168 hypothetical protein; Provisional; Region: PRK10174 199310003169 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 199310003170 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 199310003171 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 199310003172 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 199310003173 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 199310003174 putative FMN binding site [chemical binding]; other site 199310003175 pyrimidine utilization protein D; Region: RutD; TIGR03611 199310003176 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 199310003177 homotrimer interaction site [polypeptide binding]; other site 199310003178 putative active site [active] 199310003179 Isochorismatase family; Region: Isochorismatase; pfam00857 199310003180 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 199310003181 catalytic triad [active] 199310003182 conserved cis-peptide bond; other site 199310003183 pyrimidine utilization protein A; Region: RutA; TIGR03612 199310003184 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 199310003185 active site 199310003186 dimer interface [polypeptide binding]; other site 199310003187 non-prolyl cis peptide bond; other site 199310003188 insertion regions; other site 199310003189 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 199310003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310003191 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 199310003192 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 199310003193 Predicted transcriptional regulator [Transcription]; Region: COG3905 199310003194 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 199310003195 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 199310003196 Glutamate binding site [chemical binding]; other site 199310003197 NAD binding site [chemical binding]; other site 199310003198 catalytic residues [active] 199310003199 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 199310003200 Na binding site [ion binding]; other site 199310003201 FTR1 family protein; Region: TIGR00145 199310003202 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 199310003203 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 199310003204 Imelysin; Region: Peptidase_M75; pfam09375 199310003205 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 199310003206 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 199310003207 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 199310003208 hypothetical protein; Provisional; Region: PRK10536 199310003209 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 199310003210 N-glycosyltransferase; Provisional; Region: PRK11204 199310003211 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 199310003212 DXD motif; other site 199310003213 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 199310003214 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 199310003215 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 199310003216 putative active site [active] 199310003217 putative metal binding site [ion binding]; other site 199310003218 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 199310003219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310003220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310003221 metal binding site [ion binding]; metal-binding site 199310003222 active site 199310003223 I-site; other site 199310003224 integrase; Provisional; Region: PRK09692 199310003225 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310003226 active site 199310003227 Int/Topo IB signature motif; other site 199310003228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 199310003229 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 199310003230 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 199310003231 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 199310003232 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 199310003233 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310003234 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 199310003235 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 199310003236 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 199310003237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310003238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310003239 homodimer interface [polypeptide binding]; other site 199310003240 catalytic residue [active] 199310003241 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 199310003242 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 199310003243 putative active site [active] 199310003244 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 199310003245 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 199310003246 dimer interface [polypeptide binding]; other site 199310003247 active site 199310003248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 199310003249 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 199310003250 NAD(P) binding site [chemical binding]; other site 199310003251 active site 199310003252 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 199310003253 putative active site 1 [active] 199310003254 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 199310003255 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 199310003256 dimer interface [polypeptide binding]; other site 199310003257 active site 199310003258 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 199310003259 Predicted exporter [General function prediction only]; Region: COG4258 199310003260 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 199310003261 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 199310003262 active site 199310003263 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 199310003264 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 199310003265 Putative Catalytic site; other site 199310003266 DXD motif; other site 199310003267 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 199310003268 putative acyl-acceptor binding pocket; other site 199310003269 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 199310003270 active site 2 [active] 199310003271 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 199310003272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 199310003273 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 199310003274 acyl-activating enzyme (AAE) consensus motif; other site 199310003275 acyl-activating enzyme (AAE) consensus motif; other site 199310003276 active site 199310003277 AMP binding site [chemical binding]; other site 199310003278 CoA binding site [chemical binding]; other site 199310003279 Predicted membrane protein [Function unknown]; Region: COG4648 199310003280 acyl carrier protein; Provisional; Region: PRK05350 199310003281 Phosphopantetheine attachment site; Region: PP-binding; cl09936 199310003282 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 199310003283 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 199310003284 putative acyl-acceptor binding pocket; other site 199310003285 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 199310003286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310003287 S-adenosylmethionine binding site [chemical binding]; other site 199310003288 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 199310003289 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 199310003290 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 199310003291 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 199310003292 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 199310003293 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 199310003294 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 199310003295 active site 199310003296 substrate binding site [chemical binding]; other site 199310003297 catalytic site [active] 199310003298 Transposase; Region: DDE_Tnp_ISL3; pfam01610 199310003299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 199310003300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 199310003301 Transposase; Region: DDE_Tnp_ISL3; pfam01610 199310003302 Helix-turn-helix domain; Region: HTH_38; pfam13936 199310003303 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12822 199310003304 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 199310003305 putative transposase OrfB; Reviewed; Region: PHA02517 199310003306 Integrase core domain; Region: rve; pfam00665 199310003307 RTX toxin acyltransferase family; Region: HlyC; pfam02794 199310003308 HlyD family secretion protein; Region: HlyD; pfam00529 199310003309 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310003310 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310003311 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 199310003312 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 199310003313 putative active site [active] 199310003314 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310003315 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 199310003316 Walker A/P-loop; other site 199310003317 ATP binding site [chemical binding]; other site 199310003318 Q-loop/lid; other site 199310003319 ABC transporter signature motif; other site 199310003320 Walker B; other site 199310003321 D-loop; other site 199310003322 H-loop/switch region; other site 199310003323 CAAX protease self-immunity; Region: Abi; pfam02517 199310003324 FaeA-like protein; Region: FaeA; pfam04703 199310003325 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 199310003326 Fimbrial protein; Region: Fimbrial; cl01416 199310003327 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310003328 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 199310003329 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310003330 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310003331 outer membrane usher protein; Provisional; Region: PRK15193 199310003332 PapC N-terminal domain; Region: PapC_N; pfam13954 199310003333 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310003334 PapC C-terminal domain; Region: PapC_C; pfam13953 199310003335 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310003336 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310003337 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 199310003338 mannosyl binding site [chemical binding]; other site 199310003339 Fimbrial protein; Region: Fimbrial; pfam00419 199310003340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310003341 MarR family; Region: MarR_2; cl17246 199310003342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 199310003343 Homeodomain-like domain; Region: HTH_23; pfam13384 199310003344 Winged helix-turn helix; Region: HTH_29; pfam13551 199310003345 Winged helix-turn helix; Region: HTH_33; pfam13592 199310003346 DDE superfamily endonuclease; Region: DDE_3; pfam13358 199310003347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 199310003348 outer membrane receptor FepA; Provisional; Region: PRK13528 199310003349 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310003350 N-terminal plug; other site 199310003351 ligand-binding site [chemical binding]; other site 199310003352 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 199310003353 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 199310003354 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 199310003355 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 199310003356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310003357 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 199310003358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310003359 Walker A/P-loop; other site 199310003360 ATP binding site [chemical binding]; other site 199310003361 Q-loop/lid; other site 199310003362 ABC transporter signature motif; other site 199310003363 Walker B; other site 199310003364 D-loop; other site 199310003365 H-loop/switch region; other site 199310003366 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 199310003367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310003368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310003369 Walker A/P-loop; other site 199310003370 ATP binding site [chemical binding]; other site 199310003371 Q-loop/lid; other site 199310003372 ABC transporter signature motif; other site 199310003373 Walker B; other site 199310003374 D-loop; other site 199310003375 H-loop/switch region; other site 199310003376 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 199310003377 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 199310003378 homodimer interface [polypeptide binding]; other site 199310003379 active site 199310003380 TDP-binding site; other site 199310003381 acceptor substrate-binding pocket; other site 199310003382 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310003383 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 199310003384 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 199310003385 putative transposase OrfB; Reviewed; Region: PHA02517 199310003386 HTH-like domain; Region: HTH_21; pfam13276 199310003387 Integrase core domain; Region: rve; pfam00665 199310003388 Integrase core domain; Region: rve_3; pfam13683 199310003389 Transposase; Region: HTH_Tnp_1; cl17663 199310003390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310003391 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 199310003392 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310003393 N-terminal plug; other site 199310003394 ligand-binding site [chemical binding]; other site 199310003395 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 199310003396 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 199310003397 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 199310003398 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 199310003399 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310003400 Sel1-like repeats; Region: SEL1; smart00671 199310003401 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 199310003402 Sel1-like repeats; Region: SEL1; smart00671 199310003403 Sel1-like repeats; Region: SEL1; smart00671 199310003404 Sel1-like repeats; Region: SEL1; smart00671 199310003405 Sel1-like repeats; Region: SEL1; smart00671 199310003406 Sel1-like repeats; Region: SEL1; smart00671 199310003407 Sel1-like repeats; Region: SEL1; smart00671 199310003408 Sel1-like repeats; Region: SEL1; smart00671 199310003409 Sel1-like repeats; Region: SEL1; smart00671 199310003410 HsdM N-terminal domain; Region: HsdM_N; pfam12161 199310003411 Predicted GTPase [General function prediction only]; Region: COG3596 199310003412 YfjP GTPase; Region: YfjP; cd11383 199310003413 G1 box; other site 199310003414 GTP/Mg2+ binding site [chemical binding]; other site 199310003415 Switch I region; other site 199310003416 G2 box; other site 199310003417 Switch II region; other site 199310003418 G3 box; other site 199310003419 G4 box; other site 199310003420 G5 box; other site 199310003421 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 199310003422 hypothetical protein; Provisional; Region: PRK09945 199310003423 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 199310003424 hypothetical protein; Provisional; Region: PRK09945 199310003425 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 199310003426 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310003427 Autotransporter beta-domain; Region: Autotransporter; smart00869 199310003428 Domain of unknown function (DUF932); Region: DUF932; pfam06067 199310003429 Antirestriction protein; Region: Antirestrict; pfam03230 199310003430 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 199310003431 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 199310003432 MPN+ (JAMM) motif; other site 199310003433 Zinc-binding site [ion binding]; other site 199310003434 Protein of unknown function (DUF987); Region: DUF987; pfam06174 199310003435 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 199310003436 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 199310003437 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 199310003438 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 199310003439 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310003440 Methyltransferase domain; Region: Methyltransf_27; pfam13708 199310003441 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 199310003442 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 199310003443 putative ligand binding site [chemical binding]; other site 199310003444 NAD binding site [chemical binding]; other site 199310003445 dimerization interface [polypeptide binding]; other site 199310003446 catalytic site [active] 199310003447 putative hydrolase; Validated; Region: PRK09248 199310003448 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 199310003449 active site 199310003450 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 199310003451 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 199310003452 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 199310003453 curli assembly protein CsgF; Provisional; Region: PRK10050 199310003454 curli assembly protein CsgE; Provisional; Region: PRK10386 199310003455 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 199310003456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310003457 DNA binding residues [nucleotide binding] 199310003458 dimerization interface [polypeptide binding]; other site 199310003459 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 199310003460 Curlin associated repeat; Region: Curlin_rpt; pfam07012 199310003461 Curlin associated repeat; Region: Curlin_rpt; pfam07012 199310003462 major curlin subunit; Provisional; Region: csgA; PRK10051 199310003463 Curlin associated repeat; Region: Curlin_rpt; pfam07012 199310003464 Curlin associated repeat; Region: Curlin_rpt; pfam07012 199310003465 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 199310003466 Fimbrial protein; Region: Fimbrial; cl01416 199310003467 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 199310003468 putative ADP-ribose binding site [chemical binding]; other site 199310003469 putative active site [active] 199310003470 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 199310003471 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 199310003472 putative active site [active] 199310003473 catalytic site [active] 199310003474 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 199310003475 putative active site [active] 199310003476 catalytic site [active] 199310003477 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 199310003478 Acyltransferase family; Region: Acyl_transf_3; pfam01757 199310003479 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 199310003480 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 199310003481 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 199310003482 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 199310003483 Ligand binding site; other site 199310003484 DXD motif; other site 199310003485 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 199310003486 lipoprotein; Provisional; Region: PRK10175 199310003487 secY/secA suppressor protein; Provisional; Region: PRK11467 199310003488 drug efflux system protein MdtG; Provisional; Region: PRK09874 199310003489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310003490 putative substrate translocation pore; other site 199310003491 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 199310003492 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 199310003493 putative acyl-acceptor binding pocket; other site 199310003494 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 199310003495 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 199310003496 active site residue [active] 199310003497 hypothetical protein; Provisional; Region: PRK03757 199310003498 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 199310003499 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 199310003500 hydroxyglutarate oxidase; Provisional; Region: PRK11728 199310003501 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 199310003502 DNA damage-inducible protein I; Provisional; Region: PRK10597 199310003503 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 199310003504 active site 199310003505 substrate binding pocket [chemical binding]; other site 199310003506 dimer interface [polypeptide binding]; other site 199310003507 lipoprotein; Provisional; Region: PRK10598 199310003508 glutaredoxin 2; Provisional; Region: PRK10387 199310003509 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 199310003510 C-terminal domain interface [polypeptide binding]; other site 199310003511 GSH binding site (G-site) [chemical binding]; other site 199310003512 catalytic residues [active] 199310003513 putative dimer interface [polypeptide binding]; other site 199310003514 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 199310003515 N-terminal domain interface [polypeptide binding]; other site 199310003516 multidrug resistance protein MdtH; Provisional; Region: PRK11646 199310003517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310003518 putative substrate translocation pore; other site 199310003519 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 199310003520 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 199310003521 hypothetical protein; Provisional; Region: PRK11239 199310003522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 199310003523 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 199310003524 MviN-like protein; Region: MVIN; pfam03023 199310003525 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 199310003526 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 199310003527 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 199310003528 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 199310003529 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 199310003530 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 199310003531 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 199310003532 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 199310003533 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 199310003534 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 199310003535 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 199310003536 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 199310003537 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 199310003538 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 199310003539 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 199310003540 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 199310003541 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 199310003542 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 199310003543 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 199310003544 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 199310003545 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 199310003546 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 199310003547 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 199310003548 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 199310003549 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 199310003550 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 199310003551 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 199310003552 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 199310003553 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 199310003554 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 199310003555 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 199310003556 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 199310003557 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 199310003558 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 199310003559 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 199310003560 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 199310003561 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 199310003562 homodimer interface [polypeptide binding]; other site 199310003563 oligonucleotide binding site [chemical binding]; other site 199310003564 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 199310003565 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 199310003566 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 199310003567 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310003568 RNA binding surface [nucleotide binding]; other site 199310003569 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 199310003570 active site 199310003571 Maf-like protein; Region: Maf; pfam02545 199310003572 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 199310003573 active site 199310003574 dimer interface [polypeptide binding]; other site 199310003575 hypothetical protein; Provisional; Region: PRK11193 199310003576 putative phosphate acyltransferase; Provisional; Region: PRK05331 199310003577 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 199310003578 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 199310003579 dimer interface [polypeptide binding]; other site 199310003580 active site 199310003581 CoA binding pocket [chemical binding]; other site 199310003582 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 199310003583 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 199310003584 acyl carrier protein; Provisional; Region: acpP; PRK00982 199310003585 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 199310003586 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 199310003587 dimer interface [polypeptide binding]; other site 199310003588 active site 199310003589 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 199310003590 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 199310003591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310003592 catalytic residue [active] 199310003593 conserved hypothetical protein, YceG family; Region: TIGR00247 199310003594 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 199310003595 dimerization interface [polypeptide binding]; other site 199310003596 thymidylate kinase; Validated; Region: tmk; PRK00698 199310003597 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 199310003598 TMP-binding site; other site 199310003599 ATP-binding site [chemical binding]; other site 199310003600 DNA polymerase III subunit delta'; Validated; Region: PRK07993 199310003601 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 199310003602 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 199310003603 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 199310003604 active site 199310003605 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 199310003606 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 199310003607 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310003608 active site turn [active] 199310003609 phosphorylation site [posttranslational modification] 199310003610 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 199310003611 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310003612 N-terminal plug; other site 199310003613 ligand-binding site [chemical binding]; other site 199310003614 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 199310003615 nucleotide binding site/active site [active] 199310003616 HIT family signature motif; other site 199310003617 catalytic residue [active] 199310003618 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 199310003619 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 199310003620 putative dimer interface [polypeptide binding]; other site 199310003621 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 199310003622 thiamine kinase; Region: ycfN_thiK; TIGR02721 199310003623 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 199310003624 active site 199310003625 substrate binding site [chemical binding]; other site 199310003626 ATP binding site [chemical binding]; other site 199310003627 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 199310003628 beta-hexosaminidase; Provisional; Region: PRK05337 199310003629 hypothetical protein; Provisional; Region: PRK04940 199310003630 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 199310003631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310003632 hypothetical protein; Provisional; Region: PRK11280 199310003633 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310003634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 199310003635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310003636 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310003637 L,D-transpeptidase; Provisional; Region: PRK10260 199310003638 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310003639 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 199310003640 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 199310003641 DEAD-like helicases superfamily; Region: DEXDc; smart00487 199310003642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310003643 ATP binding site [chemical binding]; other site 199310003644 putative Mg++ binding site [ion binding]; other site 199310003645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310003646 nucleotide binding region [chemical binding]; other site 199310003647 ATP-binding site [chemical binding]; other site 199310003648 Predicted membrane protein [Function unknown]; Region: COG4763 199310003649 Acyltransferase family; Region: Acyl_transf_3; pfam01757 199310003650 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 199310003651 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 199310003652 FtsX-like permease family; Region: FtsX; pfam02687 199310003653 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 199310003654 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 199310003655 Walker A/P-loop; other site 199310003656 ATP binding site [chemical binding]; other site 199310003657 Q-loop/lid; other site 199310003658 ABC transporter signature motif; other site 199310003659 Walker B; other site 199310003660 D-loop; other site 199310003661 H-loop/switch region; other site 199310003662 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 199310003663 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 199310003664 FtsX-like permease family; Region: FtsX; pfam02687 199310003665 fructokinase; Reviewed; Region: PRK09557 199310003666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310003667 nucleotide binding site [chemical binding]; other site 199310003668 NAD-dependent deacetylase; Provisional; Region: PRK00481 199310003669 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 199310003670 NAD+ binding site [chemical binding]; other site 199310003671 substrate binding site [chemical binding]; other site 199310003672 Zn binding site [ion binding]; other site 199310003673 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 199310003674 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 199310003675 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 199310003676 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 199310003677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310003678 dimer interface [polypeptide binding]; other site 199310003679 conserved gate region; other site 199310003680 putative PBP binding loops; other site 199310003681 ABC-ATPase subunit interface; other site 199310003682 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 199310003683 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 199310003684 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 199310003685 dimer interface [polypeptide binding]; other site 199310003686 active site 199310003687 Int/Topo IB signature motif; other site 199310003688 exonuclease VIII; Reviewed; Region: PRK09709 199310003689 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 199310003690 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 199310003691 active site 199310003692 catalytic site [active] 199310003693 substrate binding site [chemical binding]; other site 199310003694 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 199310003695 DicB protein; Region: DicB; pfam05358 199310003696 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 199310003697 transcriptional repressor DicA; Reviewed; Region: PRK09706 199310003698 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 199310003699 primosomal protein DnaI; Provisional; Region: PRK02854 199310003700 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 199310003701 Protein of unknown function (DUF968); Region: DUF968; pfam06147 199310003702 Endodeoxyribonuclease RusA; Region: RusA; cl01885 199310003703 Antitermination protein; Region: Antiterm; pfam03589 199310003704 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 199310003705 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310003706 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 199310003707 anti-adapter protein IraM; Provisional; Region: PRK09919 199310003708 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 199310003709 Lysis protein S; Region: Lysis_S; pfam04971 199310003710 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 199310003711 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 199310003712 catalytic residues [active] 199310003713 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 199310003714 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 199310003715 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 199310003716 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 199310003717 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 199310003718 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 199310003719 gpW; Region: gpW; pfam02831 199310003720 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 199310003721 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 199310003722 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 199310003723 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 199310003724 tandem repeat interface [polypeptide binding]; other site 199310003725 oligomer interface [polypeptide binding]; other site 199310003726 active site residues [active] 199310003727 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 199310003728 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 199310003729 DNA packaging protein FI; Region: Packaging_FI; pfam14000 199310003730 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 199310003731 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 199310003732 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 199310003733 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 199310003734 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 199310003735 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 199310003736 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 199310003737 Phage-related minor tail protein [Function unknown]; Region: COG5281 199310003738 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 199310003739 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 199310003740 Phage-related protein [Function unknown]; Region: COG4718 199310003741 Phage-related protein [Function unknown]; Region: gp18; COG4672 199310003742 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 199310003743 MPN+ (JAMM) motif; other site 199310003744 Zinc-binding site [ion binding]; other site 199310003745 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 199310003746 NlpC/P60 family; Region: NLPC_P60; cl17555 199310003747 Phage-related protein, tail component [Function unknown]; Region: COG4723 199310003748 Phage-related protein, tail component [Function unknown]; Region: COG4733 199310003749 Putative phage tail protein; Region: Phage-tail_3; pfam13550 199310003750 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 199310003751 Interdomain contacts; other site 199310003752 Cytokine receptor motif; other site 199310003753 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 199310003754 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 199310003755 Fibronectin type III protein; Region: DUF3672; pfam12421 199310003756 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 199310003757 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 199310003758 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 199310003759 Methyltransferase domain; Region: Methyltransf_12; pfam08242 199310003760 S-adenosylmethionine binding site [chemical binding]; other site 199310003761 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 199310003762 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 199310003763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310003764 dimer interface [polypeptide binding]; other site 199310003765 conserved gate region; other site 199310003766 putative PBP binding loops; other site 199310003767 ABC-ATPase subunit interface; other site 199310003768 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 199310003769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310003770 Walker A/P-loop; other site 199310003771 ATP binding site [chemical binding]; other site 199310003772 Q-loop/lid; other site 199310003773 ABC transporter signature motif; other site 199310003774 Walker B; other site 199310003775 D-loop; other site 199310003776 H-loop/switch region; other site 199310003777 TOBE domain; Region: TOBE_2; pfam08402 199310003778 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 199310003779 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 199310003780 metal binding site [ion binding]; metal-binding site 199310003781 dimer interface [polypeptide binding]; other site 199310003782 Uncharacterized conserved protein [Function unknown]; Region: COG2850 199310003783 Cupin-like domain; Region: Cupin_8; pfam13621 199310003784 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310003785 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 199310003786 active site 199310003787 Int/Topo IB signature motif; other site 199310003788 BRO family, N-terminal domain; Region: Bro-N; cl10591 199310003789 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 199310003790 D5 N terminal like; Region: D5_N; smart00885 199310003791 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 199310003792 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 199310003793 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 199310003794 ssDNA binding site [nucleotide binding]; other site 199310003795 dimer interface [polypeptide binding]; other site 199310003796 tetramer (dimer of dimers) interface [polypeptide binding]; other site 199310003797 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 199310003798 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 199310003799 sensor protein PhoQ; Provisional; Region: PRK10815 199310003800 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 199310003801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 199310003802 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 199310003803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310003804 ATP binding site [chemical binding]; other site 199310003805 Mg2+ binding site [ion binding]; other site 199310003806 G-X-G motif; other site 199310003807 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 199310003808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310003809 active site 199310003810 phosphorylation site [posttranslational modification] 199310003811 intermolecular recognition site; other site 199310003812 dimerization interface [polypeptide binding]; other site 199310003813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310003814 DNA binding site [nucleotide binding] 199310003815 adenylosuccinate lyase; Provisional; Region: PRK09285 199310003816 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 199310003817 tetramer interface [polypeptide binding]; other site 199310003818 active site 199310003819 putative lysogenization regulator; Reviewed; Region: PRK00218 199310003820 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 199310003821 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 199310003822 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 199310003823 nudix motif; other site 199310003824 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 199310003825 active site 199310003826 isocitrate dehydrogenase; Validated; Region: PRK07362 199310003827 isocitrate dehydrogenase; Reviewed; Region: PRK07006 199310003828 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 199310003829 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 199310003830 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 199310003831 dimer interface [polypeptide binding]; other site 199310003832 active site 199310003833 Int/Topo IB signature motif; other site 199310003834 Transposase; Region: HTH_Tnp_1; cl17663 199310003835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310003836 putative transposase OrfB; Reviewed; Region: PHA02517 199310003837 HTH-like domain; Region: HTH_21; pfam13276 199310003838 Integrase core domain; Region: rve; pfam00665 199310003839 Integrase core domain; Region: rve_3; pfam13683 199310003840 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 199310003841 ASCH domain; Region: ASCH; pfam04266 199310003842 Protein of unknown function (DUF550); Region: DUF550; pfam04447 199310003843 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 199310003844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310003845 Walker A motif; other site 199310003846 ATP binding site [chemical binding]; other site 199310003847 Walker B motif; other site 199310003848 Integrase core domain; Region: rve; pfam00665 199310003849 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 199310003850 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 199310003851 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 199310003852 phage recombination protein Bet; Region: bet_lambda; TIGR01913 199310003853 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 199310003854 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 199310003855 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 199310003856 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 199310003857 Antirestriction protein Ral; Region: Ral; pfam11058 199310003858 Superinfection exclusion protein B; Region: SieB; pfam14163 199310003859 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 199310003860 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 199310003861 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 199310003862 Catalytic site [active] 199310003863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310003864 non-specific DNA binding site [nucleotide binding]; other site 199310003865 salt bridge; other site 199310003866 sequence-specific DNA binding site [nucleotide binding]; other site 199310003867 Bacteriophage CII protein; Region: Phage_CII; pfam05269 199310003868 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 199310003869 Replication protein P; Region: Phage_lambda_P; pfam06992 199310003870 Transposase; Region: HTH_Tnp_1; cl17663 199310003871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310003872 putative transposase OrfB; Reviewed; Region: PHA02517 199310003873 HTH-like domain; Region: HTH_21; pfam13276 199310003874 Integrase core domain; Region: rve; pfam00665 199310003875 Integrase core domain; Region: rve_3; pfam13683 199310003876 NinB protein; Region: NinB; pfam05772 199310003877 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 199310003878 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 199310003879 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 199310003880 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 199310003881 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 199310003882 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 199310003883 trimer interface [polypeptide binding]; other site 199310003884 eyelet of channel; other site 199310003885 Lysis protein S; Region: Lysis_S; pfam04971 199310003886 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 199310003887 catalytic residues [active] 199310003888 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 199310003889 Bor protein; Region: Lambda_Bor; pfam06291 199310003890 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 199310003891 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 199310003892 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 199310003893 gpW; Region: gpW; pfam02831 199310003894 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 199310003895 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 199310003896 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 199310003897 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 199310003898 tandem repeat interface [polypeptide binding]; other site 199310003899 oligomer interface [polypeptide binding]; other site 199310003900 active site residues [active] 199310003901 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 199310003902 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 199310003903 DNA packaging protein FI; Region: Packaging_FI; pfam14000 199310003904 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 199310003905 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 199310003906 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 199310003907 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 199310003908 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 199310003909 Minor tail protein T; Region: Phage_tail_T; cl05636 199310003910 Phage-related minor tail protein [Function unknown]; Region: COG5281 199310003911 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 199310003912 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 199310003913 Phage-related protein [Function unknown]; Region: gp18; COG4672 199310003914 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 199310003915 MPN+ (JAMM) motif; other site 199310003916 Zinc-binding site [ion binding]; other site 199310003917 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 199310003918 NlpC/P60 family; Region: NLPC_P60; cl17555 199310003919 Phage-related protein, tail component [Function unknown]; Region: COG4723 199310003920 Phage-related protein, tail component [Function unknown]; Region: COG4733 199310003921 Putative phage tail protein; Region: Phage-tail_3; pfam13550 199310003922 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 199310003923 Interdomain contacts; other site 199310003924 Cytokine receptor motif; other site 199310003925 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 199310003926 Fibronectin type III protein; Region: DUF3672; pfam12421 199310003927 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 199310003928 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 199310003929 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 199310003930 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310003931 ABC-ATPase subunit interface; other site 199310003932 dimer interface [polypeptide binding]; other site 199310003933 putative PBP binding regions; other site 199310003934 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 199310003935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310003936 ABC-ATPase subunit interface; other site 199310003937 dimer interface [polypeptide binding]; other site 199310003938 putative PBP binding regions; other site 199310003939 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 199310003940 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 199310003941 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 199310003942 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 199310003943 metal binding site [ion binding]; metal-binding site 199310003944 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 199310003945 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 199310003946 transcriptional regulator MirA; Provisional; Region: PRK15043 199310003947 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 199310003948 DNA binding residues [nucleotide binding] 199310003949 Sensors of blue-light using FAD; Region: BLUF; smart01034 199310003950 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310003951 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 199310003952 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 199310003953 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310003954 Autotransporter beta-domain; Region: Autotransporter; cl17461 199310003955 Autotransporter beta-domain; Region: Autotransporter; smart00869 199310003956 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 199310003957 cell division inhibitor MinD; Provisional; Region: PRK10818 199310003958 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 199310003959 Switch I; other site 199310003960 Switch II; other site 199310003961 septum formation inhibitor; Reviewed; Region: minC; PRK03511 199310003962 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 199310003963 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 199310003964 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 199310003965 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 199310003966 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 199310003967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 199310003968 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 199310003969 hypothetical protein; Provisional; Region: PRK10691 199310003970 hypothetical protein; Provisional; Region: PRK05170 199310003971 Haemolysin E (HlyE); Region: HlyE; cl11627 199310003972 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 199310003973 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 199310003974 Catalytic site [active] 199310003975 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 199310003976 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 199310003977 active site 199310003978 DNA binding site [nucleotide binding] 199310003979 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 199310003980 disulfide bond formation protein B; Provisional; Region: PRK01749 199310003981 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 199310003982 transmembrane helices; other site 199310003983 fatty acid metabolism regulator; Provisional; Region: PRK04984 199310003984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310003985 DNA-binding site [nucleotide binding]; DNA binding site 199310003986 FadR C-terminal domain; Region: FadR_C; pfam07840 199310003987 SpoVR family protein; Provisional; Region: PRK11767 199310003988 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 199310003989 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 199310003990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310003991 alanine racemase; Reviewed; Region: dadX; PRK03646 199310003992 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 199310003993 active site 199310003994 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 199310003995 substrate binding site [chemical binding]; other site 199310003996 catalytic residues [active] 199310003997 dimer interface [polypeptide binding]; other site 199310003998 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 199310003999 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 199310004000 TrkA-C domain; Region: TrkA_C; pfam02080 199310004001 Transporter associated domain; Region: CorC_HlyC; smart01091 199310004002 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 199310004003 dimer interface [polypeptide binding]; other site 199310004004 catalytic triad [active] 199310004005 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 199310004006 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 199310004007 N-acetyl-D-glucosamine binding site [chemical binding]; other site 199310004008 catalytic residue [active] 199310004009 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 199310004010 Flagellar regulator YcgR; Region: YcgR; pfam07317 199310004011 PilZ domain; Region: PilZ; pfam07238 199310004012 hypothetical protein; Provisional; Region: PRK10457 199310004013 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310004014 N-terminal plug; other site 199310004015 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 199310004016 ligand-binding site [chemical binding]; other site 199310004017 molybdenum transport protein ModD; Provisional; Region: PRK06096 199310004018 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 199310004019 dimerization interface [polypeptide binding]; other site 199310004020 active site 199310004021 Methyltransferase domain; Region: Methyltransf_31; pfam13847 199310004022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310004023 S-adenosylmethionine binding site [chemical binding]; other site 199310004024 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 199310004025 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310004026 Walker A/P-loop; other site 199310004027 ATP binding site [chemical binding]; other site 199310004028 Q-loop/lid; other site 199310004029 ABC transporter signature motif; other site 199310004030 Walker B; other site 199310004031 D-loop; other site 199310004032 H-loop/switch region; other site 199310004033 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 199310004034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310004035 ABC-ATPase subunit interface; other site 199310004036 dimer interface [polypeptide binding]; other site 199310004037 putative PBP binding regions; other site 199310004038 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 199310004039 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 199310004040 putative metal binding site [ion binding]; other site 199310004041 trehalase; Provisional; Region: treA; PRK13271 199310004042 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 199310004043 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 199310004044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 199310004045 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 199310004046 dimerization domain swap beta strand [polypeptide binding]; other site 199310004047 regulatory protein interface [polypeptide binding]; other site 199310004048 active site 199310004049 regulatory phosphorylation site [posttranslational modification]; other site 199310004050 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 199310004051 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 199310004052 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 199310004053 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 199310004054 Dak1 domain; Region: Dak1; pfam02733 199310004055 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 199310004056 PAS domain; Region: PAS; smart00091 199310004057 putative active site [active] 199310004058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310004059 Walker A motif; other site 199310004060 ATP binding site [chemical binding]; other site 199310004061 Walker B motif; other site 199310004062 arginine finger; other site 199310004063 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310004064 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 199310004065 GTP-binding protein YchF; Reviewed; Region: PRK09601 199310004066 YchF GTPase; Region: YchF; cd01900 199310004067 G1 box; other site 199310004068 GTP/Mg2+ binding site [chemical binding]; other site 199310004069 Switch I region; other site 199310004070 G2 box; other site 199310004071 Switch II region; other site 199310004072 G3 box; other site 199310004073 G4 box; other site 199310004074 G5 box; other site 199310004075 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 199310004076 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 199310004077 putative active site [active] 199310004078 catalytic residue [active] 199310004079 hypothetical protein; Provisional; Region: PRK10692 199310004080 putative transporter; Provisional; Region: PRK11660 199310004081 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 199310004082 Sulfate transporter family; Region: Sulfate_transp; pfam00916 199310004083 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 199310004084 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 199310004085 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 199310004086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310004087 active site 199310004088 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 199310004089 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 199310004090 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 199310004091 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 199310004092 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 199310004093 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 199310004094 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 199310004095 tRNA; other site 199310004096 putative tRNA binding site [nucleotide binding]; other site 199310004097 putative NADP binding site [chemical binding]; other site 199310004098 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 199310004099 peptide chain release factor 1; Validated; Region: prfA; PRK00591 199310004100 This domain is found in peptide chain release factors; Region: PCRF; smart00937 199310004101 RF-1 domain; Region: RF-1; pfam00472 199310004102 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 199310004103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310004104 hypothetical protein; Provisional; Region: PRK10278 199310004105 hypothetical protein; Provisional; Region: PRK10941 199310004106 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 199310004107 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 199310004108 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 199310004109 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 199310004110 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 199310004111 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 199310004112 cation transport regulator; Reviewed; Region: chaB; PRK09582 199310004113 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 199310004114 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 199310004115 putative active site pocket [active] 199310004116 dimerization interface [polypeptide binding]; other site 199310004117 putative catalytic residue [active] 199310004118 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 199310004119 putative invasin; Provisional; Region: PRK10177 199310004120 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 199310004121 transcriptional regulator NarL; Provisional; Region: PRK10651 199310004122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310004123 active site 199310004124 phosphorylation site [posttranslational modification] 199310004125 intermolecular recognition site; other site 199310004126 dimerization interface [polypeptide binding]; other site 199310004127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310004128 DNA binding residues [nucleotide binding] 199310004129 dimerization interface [polypeptide binding]; other site 199310004130 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 199310004131 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 199310004132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310004133 dimerization interface [polypeptide binding]; other site 199310004134 Histidine kinase; Region: HisKA_3; pfam07730 199310004135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310004136 ATP binding site [chemical binding]; other site 199310004137 Mg2+ binding site [ion binding]; other site 199310004138 G-X-G motif; other site 199310004139 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 199310004140 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 199310004141 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 199310004142 [4Fe-4S] binding site [ion binding]; other site 199310004143 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310004144 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310004145 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310004146 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 199310004147 molybdopterin cofactor binding site; other site 199310004148 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 199310004149 4Fe-4S binding domain; Region: Fer4; cl02805 199310004150 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 199310004151 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 199310004152 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 199310004153 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 199310004154 dimer interface [polypeptide binding]; other site 199310004155 active site 199310004156 CoA binding pocket [chemical binding]; other site 199310004157 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 199310004158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 199310004159 NAD(P) binding site [chemical binding]; other site 199310004160 active site 199310004161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 199310004162 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 199310004163 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 199310004164 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 199310004165 active site 199310004166 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 199310004167 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 199310004168 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 199310004169 putative di-iron ligands [ion binding]; other site 199310004170 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 199310004171 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 199310004172 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 199310004173 putative active site [active] 199310004174 putative substrate binding site [chemical binding]; other site 199310004175 putative cosubstrate binding site; other site 199310004176 catalytic site [active] 199310004177 SEC-C motif; Region: SEC-C; pfam02810 199310004178 hypothetical protein; Provisional; Region: PRK04233 199310004179 hypothetical protein; Provisional; Region: PRK10279 199310004180 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 199310004181 active site 199310004182 nucleophile elbow; other site 199310004183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310004184 active site 199310004185 response regulator of RpoS; Provisional; Region: PRK10693 199310004186 phosphorylation site [posttranslational modification] 199310004187 intermolecular recognition site; other site 199310004188 dimerization interface [polypeptide binding]; other site 199310004189 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 199310004190 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 199310004191 active site 199310004192 tetramer interface; other site 199310004193 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 199310004194 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 199310004195 thymidine kinase; Provisional; Region: PRK04296 199310004196 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 199310004197 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 199310004198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 199310004199 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 199310004200 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 199310004201 putative catalytic cysteine [active] 199310004202 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 199310004203 putative active site [active] 199310004204 metal binding site [ion binding]; metal-binding site 199310004205 hypothetical protein; Provisional; Region: PRK11111 199310004206 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 199310004207 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 199310004208 peptide binding site [polypeptide binding]; other site 199310004209 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 199310004210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310004211 dimer interface [polypeptide binding]; other site 199310004212 conserved gate region; other site 199310004213 putative PBP binding loops; other site 199310004214 ABC-ATPase subunit interface; other site 199310004215 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 199310004216 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 199310004217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310004218 dimer interface [polypeptide binding]; other site 199310004219 conserved gate region; other site 199310004220 putative PBP binding loops; other site 199310004221 ABC-ATPase subunit interface; other site 199310004222 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 199310004223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310004224 Walker A/P-loop; other site 199310004225 ATP binding site [chemical binding]; other site 199310004226 Q-loop/lid; other site 199310004227 ABC transporter signature motif; other site 199310004228 Walker B; other site 199310004229 D-loop; other site 199310004230 H-loop/switch region; other site 199310004231 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 199310004232 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 199310004233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310004234 Walker A/P-loop; other site 199310004235 ATP binding site [chemical binding]; other site 199310004236 Q-loop/lid; other site 199310004237 ABC transporter signature motif; other site 199310004238 Walker B; other site 199310004239 D-loop; other site 199310004240 H-loop/switch region; other site 199310004241 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 199310004242 dsDNA-mimic protein; Reviewed; Region: PRK05094 199310004243 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 199310004244 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 199310004245 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 199310004246 putative active site [active] 199310004247 catalytic site [active] 199310004248 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 199310004249 putative active site [active] 199310004250 catalytic site [active] 199310004251 voltage-gated potassium channel; Provisional; Region: PRK10537 199310004252 Ion channel; Region: Ion_trans_2; pfam07885 199310004253 TrkA-N domain; Region: TrkA_N; pfam02254 199310004254 YciI-like protein; Reviewed; Region: PRK11370 199310004255 transport protein TonB; Provisional; Region: PRK10819 199310004256 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 199310004257 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 199310004258 intracellular septation protein A; Reviewed; Region: PRK00259 199310004259 hypothetical protein; Provisional; Region: PRK02868 199310004260 outer membrane protein W; Provisional; Region: PRK10959 199310004261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 199310004262 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 199310004263 dimerization interface [polypeptide binding]; other site 199310004264 metal binding site [ion binding]; metal-binding site 199310004265 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 199310004266 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 199310004267 substrate binding site [chemical binding]; other site 199310004268 active site 199310004269 catalytic residues [active] 199310004270 heterodimer interface [polypeptide binding]; other site 199310004271 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 199310004272 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 199310004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310004274 catalytic residue [active] 199310004275 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 199310004276 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 199310004277 glutamine binding [chemical binding]; other site 199310004278 catalytic triad [active] 199310004279 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 199310004280 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 199310004281 anthranilate synthase component I; Provisional; Region: PRK13564 199310004282 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 199310004283 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 199310004284 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 199310004285 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 199310004286 active site 199310004287 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 199310004288 hypothetical protein; Provisional; Region: PRK11630 199310004289 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 199310004290 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 199310004291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310004292 RNA binding surface [nucleotide binding]; other site 199310004293 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 199310004294 probable active site [active] 199310004295 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 199310004296 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 199310004297 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 199310004298 homodimer interface [polypeptide binding]; other site 199310004299 Walker A motif; other site 199310004300 ATP binding site [chemical binding]; other site 199310004301 hydroxycobalamin binding site [chemical binding]; other site 199310004302 Walker B motif; other site 199310004303 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 199310004304 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 199310004305 NADP binding site [chemical binding]; other site 199310004306 homodimer interface [polypeptide binding]; other site 199310004307 active site 199310004308 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 199310004309 putative inner membrane peptidase; Provisional; Region: PRK11778 199310004310 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 199310004311 tandem repeat interface [polypeptide binding]; other site 199310004312 oligomer interface [polypeptide binding]; other site 199310004313 active site residues [active] 199310004314 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310004315 hypothetical protein; Provisional; Region: PRK11037 199310004316 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 199310004317 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 199310004318 active site 199310004319 interdomain interaction site; other site 199310004320 putative metal-binding site [ion binding]; other site 199310004321 nucleotide binding site [chemical binding]; other site 199310004322 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 199310004323 domain I; other site 199310004324 DNA binding groove [nucleotide binding] 199310004325 phosphate binding site [ion binding]; other site 199310004326 domain II; other site 199310004327 domain III; other site 199310004328 nucleotide binding site [chemical binding]; other site 199310004329 catalytic site [active] 199310004330 domain IV; other site 199310004331 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 199310004332 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 199310004333 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 199310004334 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 199310004335 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 199310004336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310004337 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 199310004338 substrate binding site [chemical binding]; other site 199310004339 putative dimerization interface [polypeptide binding]; other site 199310004340 aconitate hydratase; Validated; Region: PRK09277 199310004341 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 199310004342 substrate binding site [chemical binding]; other site 199310004343 ligand binding site [chemical binding]; other site 199310004344 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 199310004345 substrate binding site [chemical binding]; other site 199310004346 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 199310004347 dimerization interface [polypeptide binding]; other site 199310004348 active site 199310004349 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 199310004350 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 199310004351 active site 199310004352 Predicted membrane protein [Function unknown]; Region: COG3771 199310004353 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 199310004354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 199310004355 TPR motif; other site 199310004356 binding surface 199310004357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310004358 binding surface 199310004359 TPR motif; other site 199310004360 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 199310004361 active site 199310004362 dimer interface [polypeptide binding]; other site 199310004363 translation initiation factor Sui1; Validated; Region: PRK06824 199310004364 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 199310004365 putative rRNA binding site [nucleotide binding]; other site 199310004366 lipoprotein; Provisional; Region: PRK10540 199310004367 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310004368 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 199310004369 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310004370 hypothetical protein; Provisional; Region: PRK13658 199310004371 RNase II stability modulator; Provisional; Region: PRK10060 199310004372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310004373 putative active site [active] 199310004374 heme pocket [chemical binding]; other site 199310004375 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310004376 metal binding site [ion binding]; metal-binding site 199310004377 active site 199310004378 I-site; other site 199310004379 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310004380 exoribonuclease II; Provisional; Region: PRK05054 199310004381 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 199310004382 RNB domain; Region: RNB; pfam00773 199310004383 S1 RNA binding domain; Region: S1; pfam00575 199310004384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 199310004385 Uncharacterized conserved protein [Function unknown]; Region: COG2128 199310004386 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 199310004387 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 199310004388 NAD binding site [chemical binding]; other site 199310004389 homotetramer interface [polypeptide binding]; other site 199310004390 homodimer interface [polypeptide binding]; other site 199310004391 substrate binding site [chemical binding]; other site 199310004392 active site 199310004393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 199310004394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310004395 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 199310004396 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310004397 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310004398 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 199310004399 Protein export membrane protein; Region: SecD_SecF; cl14618 199310004400 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 199310004401 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 199310004402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310004403 putative substrate translocation pore; other site 199310004404 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 199310004405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310004406 Walker A/P-loop; other site 199310004407 ATP binding site [chemical binding]; other site 199310004408 Q-loop/lid; other site 199310004409 ABC transporter signature motif; other site 199310004410 Walker B; other site 199310004411 D-loop; other site 199310004412 H-loop/switch region; other site 199310004413 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 199310004414 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310004415 Walker A/P-loop; other site 199310004416 ATP binding site [chemical binding]; other site 199310004417 Q-loop/lid; other site 199310004418 ABC transporter signature motif; other site 199310004419 Walker B; other site 199310004420 D-loop; other site 199310004421 H-loop/switch region; other site 199310004422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 199310004423 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 199310004424 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 199310004425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310004426 dimer interface [polypeptide binding]; other site 199310004427 conserved gate region; other site 199310004428 putative PBP binding loops; other site 199310004429 ABC-ATPase subunit interface; other site 199310004430 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 199310004431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310004432 dimer interface [polypeptide binding]; other site 199310004433 conserved gate region; other site 199310004434 putative PBP binding loops; other site 199310004435 ABC-ATPase subunit interface; other site 199310004436 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 199310004437 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 199310004438 peptide binding site [polypeptide binding]; other site 199310004439 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 199310004440 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 199310004441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310004442 Walker A motif; other site 199310004443 ATP binding site [chemical binding]; other site 199310004444 Walker B motif; other site 199310004445 arginine finger; other site 199310004446 phage shock protein PspA; Provisional; Region: PRK10698 199310004447 phage shock protein B; Provisional; Region: pspB; PRK09458 199310004448 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 199310004449 phage shock protein C; Region: phageshock_pspC; TIGR02978 199310004450 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 199310004451 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 199310004452 active site residue [active] 199310004453 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 199310004454 sucrose phosphorylase; Provisional; Region: PRK13840 199310004455 active site 199310004456 homodimer interface [polypeptide binding]; other site 199310004457 catalytic site [active] 199310004458 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 199310004459 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 199310004460 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 199310004461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310004462 dimer interface [polypeptide binding]; other site 199310004463 conserved gate region; other site 199310004464 putative PBP binding loops; other site 199310004465 ABC-ATPase subunit interface; other site 199310004466 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 199310004467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310004468 dimer interface [polypeptide binding]; other site 199310004469 conserved gate region; other site 199310004470 putative PBP binding loops; other site 199310004471 ABC-ATPase subunit interface; other site 199310004472 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310004473 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 199310004474 putative NAD(P) binding site [chemical binding]; other site 199310004475 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 199310004476 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 199310004477 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 199310004478 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 199310004479 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 199310004480 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 199310004481 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 199310004482 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 199310004483 beta-phosphoglucomutase; Region: bPGM; TIGR01990 199310004484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310004485 motif II; other site 199310004486 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 199310004487 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 199310004488 Walker A/P-loop; other site 199310004489 ATP binding site [chemical binding]; other site 199310004490 Q-loop/lid; other site 199310004491 ABC transporter signature motif; other site 199310004492 Walker B; other site 199310004493 D-loop; other site 199310004494 H-loop/switch region; other site 199310004495 TOBE domain; Region: TOBE_2; pfam08402 199310004496 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 199310004497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 199310004498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310004499 DNA binding site [nucleotide binding] 199310004500 domain linker motif; other site 199310004501 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 199310004502 putative dimerization interface [polypeptide binding]; other site 199310004503 putative ligand binding site [chemical binding]; other site 199310004504 Predicted ATPase [General function prediction only]; Region: COG3106 199310004505 hypothetical protein; Provisional; Region: PRK05415 199310004506 TIGR01620 family protein; Region: hyp_HI0043 199310004507 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 199310004508 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 199310004509 putative aromatic amino acid binding site; other site 199310004510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310004511 Walker A motif; other site 199310004512 ATP binding site [chemical binding]; other site 199310004513 Walker B motif; other site 199310004514 arginine finger; other site 199310004515 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 199310004516 dimer interface [polypeptide binding]; other site 199310004517 catalytic triad [active] 199310004518 peroxidatic and resolving cysteines [active] 199310004519 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 199310004520 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 199310004521 active site 199310004522 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 199310004523 NADH(P)-binding; Region: NAD_binding_10; pfam13460 199310004524 putative NAD(P) binding site [chemical binding]; other site 199310004525 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 199310004526 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310004527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310004528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310004529 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 199310004530 putative effector binding pocket; other site 199310004531 putative dimerization interface [polypeptide binding]; other site 199310004532 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 199310004533 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 199310004534 peptide binding site [polypeptide binding]; other site 199310004535 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 199310004536 Mechanosensitive ion channel; Region: MS_channel; pfam00924 199310004537 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 199310004538 universal stress protein UspE; Provisional; Region: PRK11175 199310004539 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 199310004540 Ligand Binding Site [chemical binding]; other site 199310004541 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 199310004542 Ligand Binding Site [chemical binding]; other site 199310004543 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 199310004544 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 199310004545 ligand binding site [chemical binding]; other site 199310004546 flexible hinge region; other site 199310004547 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 199310004548 putative switch regulator; other site 199310004549 non-specific DNA interactions [nucleotide binding]; other site 199310004550 DNA binding site [nucleotide binding] 199310004551 sequence specific DNA binding site [nucleotide binding]; other site 199310004552 putative cAMP binding site [chemical binding]; other site 199310004553 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 199310004554 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 199310004555 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 199310004556 DNA binding site [nucleotide binding] 199310004557 active site 199310004558 Cupin domain; Region: Cupin_2; cl17218 199310004559 Helix-turn-helix domain; Region: HTH_18; pfam12833 199310004560 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310004561 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 199310004562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 199310004563 Smr domain; Region: Smr; pfam01713 199310004564 PAS domain S-box; Region: sensory_box; TIGR00229 199310004565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310004566 putative active site [active] 199310004567 heme pocket [chemical binding]; other site 199310004568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310004569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310004570 metal binding site [ion binding]; metal-binding site 199310004571 active site 199310004572 I-site; other site 199310004573 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 199310004574 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 199310004575 Cl binding site [ion binding]; other site 199310004576 oligomer interface [polypeptide binding]; other site 199310004577 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 199310004578 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 199310004579 ATP binding site [chemical binding]; other site 199310004580 Mg++ binding site [ion binding]; other site 199310004581 motif III; other site 199310004582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310004583 nucleotide binding region [chemical binding]; other site 199310004584 ATP-binding site [chemical binding]; other site 199310004585 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 199310004586 putative RNA binding site [nucleotide binding]; other site 199310004587 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 199310004588 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 199310004589 Ligand Binding Site [chemical binding]; other site 199310004590 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310004591 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 199310004592 DNA binding site [nucleotide binding] 199310004593 active site 199310004594 Int/Topo IB signature motif; other site 199310004595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 199310004596 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 199310004597 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 199310004598 Ligand Binding Site [chemical binding]; other site 199310004599 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 199310004600 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 199310004601 trimer interface [polypeptide binding]; other site 199310004602 eyelet of channel; other site 199310004603 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 199310004604 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 199310004605 dimer interface [polypeptide binding]; other site 199310004606 PYR/PP interface [polypeptide binding]; other site 199310004607 TPP binding site [chemical binding]; other site 199310004608 substrate binding site [chemical binding]; other site 199310004609 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 199310004610 Domain of unknown function; Region: EKR; smart00890 199310004611 4Fe-4S binding domain; Region: Fer4_6; pfam12837 199310004612 4Fe-4S binding domain; Region: Fer4; pfam00037 199310004613 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 199310004614 TPP-binding site [chemical binding]; other site 199310004615 dimer interface [polypeptide binding]; other site 199310004616 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 199310004617 Domain of unknown function (DUF333); Region: DUF333; pfam03891 199310004618 heat-inducible protein; Provisional; Region: PRK10449 199310004619 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 199310004620 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 199310004621 putative ligand binding site [chemical binding]; other site 199310004622 putative NAD binding site [chemical binding]; other site 199310004623 catalytic site [active] 199310004624 hypothetical protein; Provisional; Region: PRK10695 199310004625 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 199310004626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 199310004627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310004628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310004629 active site 199310004630 catalytic tetrad [active] 199310004631 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 199310004632 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 199310004633 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 199310004634 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 199310004635 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 199310004636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310004637 S-adenosylmethionine binding site [chemical binding]; other site 199310004638 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 199310004639 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 199310004640 active site 199310004641 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 199310004642 active site 199310004643 catalytic residues [active] 199310004644 probable pectinesterase/pectinesterase inhibitor; Region: PLN02488 199310004645 azoreductase; Reviewed; Region: PRK00170 199310004646 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 199310004647 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 199310004648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310004649 ATP binding site [chemical binding]; other site 199310004650 putative Mg++ binding site [ion binding]; other site 199310004651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310004652 nucleotide binding region [chemical binding]; other site 199310004653 ATP-binding site [chemical binding]; other site 199310004654 Helicase associated domain (HA2); Region: HA2; pfam04408 199310004655 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 199310004656 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 199310004657 Uncharacterized conserved protein [Function unknown]; Region: COG1434 199310004658 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 199310004659 putative active site [active] 199310004660 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 199310004661 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 199310004662 NAD binding site [chemical binding]; other site 199310004663 catalytic residues [active] 199310004664 substrate binding site [chemical binding]; other site 199310004665 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 199310004666 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 199310004667 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 199310004668 cytochrome b561; Provisional; Region: PRK11513 199310004669 hypothetical protein; Provisional; Region: PRK10040 199310004670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 199310004671 dimer interface [polypeptide binding]; other site 199310004672 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 199310004673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310004674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310004675 dimerization interface [polypeptide binding]; other site 199310004676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 199310004677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 199310004678 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 199310004679 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 199310004680 hypothetical protein; Provisional; Region: PRK11415 199310004681 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 199310004682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310004683 Coenzyme A binding pocket [chemical binding]; other site 199310004684 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 199310004685 putative trimer interface [polypeptide binding]; other site 199310004686 putative CoA binding site [chemical binding]; other site 199310004687 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 199310004688 putative trimer interface [polypeptide binding]; other site 199310004689 putative CoA binding site [chemical binding]; other site 199310004690 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 199310004691 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 199310004692 gating phenylalanine in ion channel; other site 199310004693 tellurite resistance protein TehB; Provisional; Region: PRK11207 199310004694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310004695 S-adenosylmethionine binding site [chemical binding]; other site 199310004696 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 199310004697 benzoate transporter; Region: benE; TIGR00843 199310004698 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 199310004699 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 199310004700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310004701 non-specific DNA binding site [nucleotide binding]; other site 199310004702 salt bridge; other site 199310004703 sequence-specific DNA binding site [nucleotide binding]; other site 199310004704 Cupin domain; Region: Cupin_2; pfam07883 199310004705 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 199310004706 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 199310004707 Peptidase family U32; Region: Peptidase_U32; pfam01136 199310004708 Collagenase; Region: DUF3656; pfam12392 199310004709 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 199310004710 Helix-turn-helix; Region: HTH_3; pfam01381 199310004711 sequence-specific DNA binding site [nucleotide binding]; other site 199310004712 salt bridge; other site 199310004713 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 199310004714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310004715 DNA-binding site [nucleotide binding]; DNA binding site 199310004716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310004717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310004718 homodimer interface [polypeptide binding]; other site 199310004719 catalytic residue [active] 199310004720 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 199310004721 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 199310004722 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 199310004723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310004724 Walker A/P-loop; other site 199310004725 ATP binding site [chemical binding]; other site 199310004726 Q-loop/lid; other site 199310004727 ABC transporter signature motif; other site 199310004728 Walker B; other site 199310004729 D-loop; other site 199310004730 H-loop/switch region; other site 199310004731 TOBE domain; Region: TOBE_2; pfam08402 199310004732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310004733 dimer interface [polypeptide binding]; other site 199310004734 conserved gate region; other site 199310004735 putative PBP binding loops; other site 199310004736 ABC-ATPase subunit interface; other site 199310004737 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 199310004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 199310004739 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 199310004740 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 199310004741 tetrameric interface [polypeptide binding]; other site 199310004742 NAD binding site [chemical binding]; other site 199310004743 catalytic residues [active] 199310004744 substrate binding site [chemical binding]; other site 199310004745 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 199310004746 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 199310004747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 199310004748 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 199310004749 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 199310004750 Coenzyme A binding pocket [chemical binding]; other site 199310004751 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 199310004752 PQQ-like domain; Region: PQQ_2; pfam13360 199310004753 L-asparagine permease; Provisional; Region: PRK15049 199310004754 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 199310004755 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 199310004756 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 199310004757 dimer interface [polypeptide binding]; other site 199310004758 substrate binding pocket (H-site) [chemical binding]; other site 199310004759 N-terminal domain interface [polypeptide binding]; other site 199310004760 PAAR motif; Region: PAAR_motif; pfam05488 199310004761 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 199310004762 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 199310004763 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 199310004764 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 199310004765 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 199310004766 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 199310004767 PAAR motif; Region: PAAR_motif; pfam05488 199310004768 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 199310004769 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 199310004770 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 199310004771 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 199310004772 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 199310004773 putative active site [active] 199310004774 putative Zn binding site [ion binding]; other site 199310004775 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 199310004776 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 199310004777 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 199310004778 hypothetical protein; Provisional; Region: PRK10281 199310004779 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 199310004780 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 199310004781 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 199310004782 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 199310004783 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 199310004784 [4Fe-4S] binding site [ion binding]; other site 199310004785 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310004786 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310004787 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310004788 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 199310004789 molybdopterin cofactor binding site; other site 199310004790 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 199310004791 aromatic amino acid exporter; Provisional; Region: PRK11689 199310004792 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 199310004793 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 199310004794 [4Fe-4S] binding site [ion binding]; other site 199310004795 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310004796 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 199310004797 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 199310004798 molybdopterin cofactor binding site; other site 199310004799 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 199310004800 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 199310004801 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 199310004802 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 199310004803 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 199310004804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310004805 non-specific DNA binding site [nucleotide binding]; other site 199310004806 salt bridge; other site 199310004807 sequence-specific DNA binding site [nucleotide binding]; other site 199310004808 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 199310004809 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 199310004810 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 199310004811 NAD binding site [chemical binding]; other site 199310004812 substrate binding site [chemical binding]; other site 199310004813 catalytic Zn binding site [ion binding]; other site 199310004814 tetramer interface [polypeptide binding]; other site 199310004815 structural Zn binding site [ion binding]; other site 199310004816 malate dehydrogenase; Provisional; Region: PRK13529 199310004817 Malic enzyme, N-terminal domain; Region: malic; pfam00390 199310004818 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 199310004819 NAD(P) binding site [chemical binding]; other site 199310004820 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 199310004821 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 199310004822 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 199310004823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310004824 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 199310004825 putative active site [active] 199310004826 heme pocket [chemical binding]; other site 199310004827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310004828 putative active site [active] 199310004829 heme pocket [chemical binding]; other site 199310004830 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310004831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310004832 metal binding site [ion binding]; metal-binding site 199310004833 active site 199310004834 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310004835 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310004836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 199310004837 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 199310004838 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 199310004839 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 199310004840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310004841 catalytic residue [active] 199310004842 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 199310004843 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 199310004844 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 199310004845 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 199310004846 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 199310004847 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 199310004848 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 199310004849 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 199310004850 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 199310004851 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 199310004852 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 199310004853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310004854 FeS/SAM binding site; other site 199310004855 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 199310004856 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 199310004857 Sulfatase; Region: Sulfatase; pfam00884 199310004858 transcriptional regulator YdeO; Provisional; Region: PRK09940 199310004859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310004860 putative oxidoreductase; Provisional; Region: PRK09939 199310004861 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 199310004862 putative molybdopterin cofactor binding site [chemical binding]; other site 199310004863 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 199310004864 putative molybdopterin cofactor binding site; other site 199310004865 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 199310004866 mannosyl binding site [chemical binding]; other site 199310004867 Fimbrial protein; Region: Fimbrial; pfam00419 199310004868 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310004869 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310004870 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 199310004871 PapC N-terminal domain; Region: PapC_N; pfam13954 199310004872 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310004873 PapC C-terminal domain; Region: PapC_C; pfam13953 199310004874 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 199310004875 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310004876 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310004877 Fimbrial protein; Region: Fimbrial; cl01416 199310004878 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 199310004879 NADH(P)-binding; Region: NAD_binding_10; pfam13460 199310004880 NAD(P) binding site [chemical binding]; other site 199310004881 putative active site [active] 199310004882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310004883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310004884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310004885 dimerization interface [polypeptide binding]; other site 199310004886 HipA N-terminal domain; Region: Couple_hipA; pfam13657 199310004887 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 199310004888 HipA-like N-terminal domain; Region: HipA_N; pfam07805 199310004889 HipA-like C-terminal domain; Region: HipA_C; pfam07804 199310004890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 199310004891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310004892 non-specific DNA binding site [nucleotide binding]; other site 199310004893 salt bridge; other site 199310004894 sequence-specific DNA binding site [nucleotide binding]; other site 199310004895 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 199310004896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310004897 S-adenosylmethionine binding site [chemical binding]; other site 199310004898 Predicted membrane protein [Function unknown]; Region: COG3781 199310004899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310004900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310004901 metal binding site [ion binding]; metal-binding site 199310004902 active site 199310004903 I-site; other site 199310004904 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 199310004905 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 199310004906 glutaminase; Provisional; Region: PRK00971 199310004907 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 199310004908 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 199310004909 NAD(P) binding site [chemical binding]; other site 199310004910 catalytic residues [active] 199310004911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310004912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310004913 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 199310004914 putative dimerization interface [polypeptide binding]; other site 199310004915 putative arabinose transporter; Provisional; Region: PRK03545 199310004916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310004917 putative substrate translocation pore; other site 199310004918 inner membrane protein; Provisional; Region: PRK10995 199310004919 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 199310004920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 199310004921 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 199310004922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310004923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310004924 hypothetical protein; Provisional; Region: PRK10106 199310004925 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 199310004926 beta-galactosidase; Region: BGL; TIGR03356 199310004927 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 199310004928 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 199310004929 trimer interface; other site 199310004930 sugar binding site [chemical binding]; other site 199310004931 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 199310004932 active site 199310004933 methionine cluster; other site 199310004934 phosphorylation site [posttranslational modification] 199310004935 metal binding site [ion binding]; metal-binding site 199310004936 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 199310004937 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 199310004938 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 199310004939 active site 199310004940 P-loop; other site 199310004941 phosphorylation site [posttranslational modification] 199310004942 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 199310004943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310004944 DNA-binding site [nucleotide binding]; DNA binding site 199310004945 UTRA domain; Region: UTRA; pfam07702 199310004946 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 199310004947 EamA-like transporter family; Region: EamA; pfam00892 199310004948 EamA-like transporter family; Region: EamA; pfam00892 199310004949 putative transporter; Provisional; Region: PRK10054 199310004950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310004951 putative substrate translocation pore; other site 199310004952 diguanylate cyclase; Provisional; Region: PRK09894 199310004953 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 199310004954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310004955 metal binding site [ion binding]; metal-binding site 199310004956 active site 199310004957 I-site; other site 199310004958 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 199310004959 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 199310004960 active site 199310004961 Zn binding site [ion binding]; other site 199310004962 malonic semialdehyde reductase; Provisional; Region: PRK10538 199310004963 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 199310004964 putative NAD(P) binding site [chemical binding]; other site 199310004965 homodimer interface [polypeptide binding]; other site 199310004966 homotetramer interface [polypeptide binding]; other site 199310004967 active site 199310004968 Transcriptional regulators [Transcription]; Region: GntR; COG1802 199310004969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310004970 DNA-binding site [nucleotide binding]; DNA binding site 199310004971 FCD domain; Region: FCD; pfam07729 199310004972 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 199310004973 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 199310004974 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 199310004975 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 199310004976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310004977 metabolite-proton symporter; Region: 2A0106; TIGR00883 199310004978 putative substrate translocation pore; other site 199310004979 putative oxidoreductase; Provisional; Region: PRK10083 199310004980 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 199310004981 putative NAD(P) binding site [chemical binding]; other site 199310004982 catalytic Zn binding site [ion binding]; other site 199310004983 structural Zn binding site [ion binding]; other site 199310004984 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 199310004985 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 199310004986 putative active site pocket [active] 199310004987 putative metal binding site [ion binding]; other site 199310004988 hypothetical protein; Provisional; Region: PRK02237 199310004989 hypothetical protein; Provisional; Region: PRK13659 199310004990 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 199310004991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310004992 Coenzyme A binding pocket [chemical binding]; other site 199310004993 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 199310004994 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 199310004995 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 199310004996 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 199310004997 putative [Fe4-S4] binding site [ion binding]; other site 199310004998 putative molybdopterin cofactor binding site [chemical binding]; other site 199310004999 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 199310005000 putative molybdopterin cofactor binding site; other site 199310005001 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 199310005002 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 199310005003 putative [Fe4-S4] binding site [ion binding]; other site 199310005004 putative molybdopterin cofactor binding site [chemical binding]; other site 199310005005 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 199310005006 putative molybdopterin cofactor binding site; other site 199310005007 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 199310005008 4Fe-4S binding domain; Region: Fer4; cl02805 199310005009 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 199310005010 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 199310005011 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 199310005012 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 199310005013 Cl- selectivity filter; other site 199310005014 Cl- binding residues [ion binding]; other site 199310005015 pore gating glutamate residue; other site 199310005016 dimer interface [polypeptide binding]; other site 199310005017 putative dithiobiotin synthetase; Provisional; Region: PRK12374 199310005018 AAA domain; Region: AAA_26; pfam13500 199310005019 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 199310005020 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 199310005021 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310005022 nucleotide binding site [chemical binding]; other site 199310005023 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 199310005024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310005025 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 199310005026 dimerization interface [polypeptide binding]; other site 199310005027 substrate binding pocket [chemical binding]; other site 199310005028 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 199310005029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005030 putative substrate translocation pore; other site 199310005031 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 199310005032 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 199310005033 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 199310005034 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 199310005035 Domain of unknown function DUF20; Region: UPF0118; pfam01594 199310005036 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 199310005037 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 199310005038 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 199310005039 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 199310005040 ligand binding site [chemical binding]; other site 199310005041 homodimer interface [polypeptide binding]; other site 199310005042 NAD(P) binding site [chemical binding]; other site 199310005043 trimer interface B [polypeptide binding]; other site 199310005044 trimer interface A [polypeptide binding]; other site 199310005045 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 199310005046 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310005047 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310005048 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310005049 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 199310005050 Spore germination protein; Region: Spore_permease; cl17796 199310005051 dihydromonapterin reductase; Provisional; Region: PRK06483 199310005052 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 199310005053 NADP binding site [chemical binding]; other site 199310005054 substrate binding pocket [chemical binding]; other site 199310005055 active site 199310005056 GlpM protein; Region: GlpM; pfam06942 199310005057 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 199310005058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310005059 active site 199310005060 phosphorylation site [posttranslational modification] 199310005061 intermolecular recognition site; other site 199310005062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310005063 DNA binding site [nucleotide binding] 199310005064 sensor protein RstB; Provisional; Region: PRK10604 199310005065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310005066 dimerization interface [polypeptide binding]; other site 199310005067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310005068 dimer interface [polypeptide binding]; other site 199310005069 phosphorylation site [posttranslational modification] 199310005070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310005071 ATP binding site [chemical binding]; other site 199310005072 Mg2+ binding site [ion binding]; other site 199310005073 G-X-G motif; other site 199310005074 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 199310005075 fumarate hydratase; Reviewed; Region: fumC; PRK00485 199310005076 Class II fumarases; Region: Fumarase_classII; cd01362 199310005077 active site 199310005078 tetramer interface [polypeptide binding]; other site 199310005079 fumarate hydratase; Provisional; Region: PRK15389 199310005080 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 199310005081 Fumarase C-terminus; Region: Fumerase_C; pfam05683 199310005082 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 199310005083 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 199310005084 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 199310005085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 199310005086 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 199310005087 putative outer membrane porin protein; Provisional; Region: PRK11379 199310005088 glucuronide transporter; Provisional; Region: PRK09848 199310005089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005090 putative substrate translocation pore; other site 199310005091 beta-D-glucuronidase; Provisional; Region: PRK10150 199310005092 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 199310005093 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 199310005094 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 199310005095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 199310005096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310005097 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 199310005098 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 199310005099 NAD binding site [chemical binding]; other site 199310005100 substrate binding site [chemical binding]; other site 199310005101 homotetramer interface [polypeptide binding]; other site 199310005102 homodimer interface [polypeptide binding]; other site 199310005103 active site 199310005104 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 199310005105 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310005106 DNA binding site [nucleotide binding] 199310005107 domain linker motif; other site 199310005108 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 199310005109 putative dimerization interface [polypeptide binding]; other site 199310005110 putative ligand binding site [chemical binding]; other site 199310005111 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 199310005112 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 199310005113 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310005114 active site turn [active] 199310005115 phosphorylation site [posttranslational modification] 199310005116 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 199310005117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310005118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310005119 homodimer interface [polypeptide binding]; other site 199310005120 catalytic residue [active] 199310005121 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 199310005122 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 199310005123 active site 199310005124 purine riboside binding site [chemical binding]; other site 199310005125 putative oxidoreductase; Provisional; Region: PRK11579 199310005126 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 199310005127 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 199310005128 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 199310005129 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 199310005130 electron transport complex protein RsxA; Provisional; Region: PRK05151 199310005131 electron transport complex protein RnfB; Provisional; Region: PRK05113 199310005132 Putative Fe-S cluster; Region: FeS; pfam04060 199310005133 4Fe-4S binding domain; Region: Fer4; pfam00037 199310005134 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 199310005135 SLBB domain; Region: SLBB; pfam10531 199310005136 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 199310005137 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 199310005138 electron transport complex protein RnfG; Validated; Region: PRK01908 199310005139 electron transport complex RsxE subunit; Provisional; Region: PRK12405 199310005140 endonuclease III; Provisional; Region: PRK10702 199310005141 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 199310005142 minor groove reading motif; other site 199310005143 helix-hairpin-helix signature motif; other site 199310005144 substrate binding pocket [chemical binding]; other site 199310005145 active site 199310005146 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 199310005147 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 199310005148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005149 putative substrate translocation pore; other site 199310005150 POT family; Region: PTR2; pfam00854 199310005151 glutathionine S-transferase; Provisional; Region: PRK10542 199310005152 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 199310005153 C-terminal domain interface [polypeptide binding]; other site 199310005154 GSH binding site (G-site) [chemical binding]; other site 199310005155 dimer interface [polypeptide binding]; other site 199310005156 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 199310005157 N-terminal domain interface [polypeptide binding]; other site 199310005158 dimer interface [polypeptide binding]; other site 199310005159 substrate binding pocket (H-site) [chemical binding]; other site 199310005160 pyridoxamine kinase; Validated; Region: PRK05756 199310005161 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 199310005162 dimer interface [polypeptide binding]; other site 199310005163 pyridoxal binding site [chemical binding]; other site 199310005164 ATP binding site [chemical binding]; other site 199310005165 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 199310005166 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 199310005167 active site 199310005168 HIGH motif; other site 199310005169 dimer interface [polypeptide binding]; other site 199310005170 KMSKS motif; other site 199310005171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310005172 RNA binding surface [nucleotide binding]; other site 199310005173 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 199310005174 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 199310005175 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 199310005176 lysozyme inhibitor; Provisional; Region: PRK11372 199310005177 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 199310005178 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 199310005179 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 199310005180 transcriptional regulator SlyA; Provisional; Region: PRK03573 199310005181 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 199310005182 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 199310005183 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 199310005184 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310005185 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310005186 Fusaric acid resistance protein family; Region: FUSC; pfam04632 199310005187 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 199310005188 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 199310005189 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 199310005190 E-class dimer interface [polypeptide binding]; other site 199310005191 P-class dimer interface [polypeptide binding]; other site 199310005192 active site 199310005193 Cu2+ binding site [ion binding]; other site 199310005194 Zn2+ binding site [ion binding]; other site 199310005195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310005196 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310005197 active site 199310005198 catalytic tetrad [active] 199310005199 Predicted Fe-S protein [General function prediction only]; Region: COG3313 199310005200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 199310005201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310005202 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 199310005203 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 199310005204 FMN binding site [chemical binding]; other site 199310005205 active site 199310005206 substrate binding site [chemical binding]; other site 199310005207 catalytic residue [active] 199310005208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 199310005209 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 199310005210 dimer interface [polypeptide binding]; other site 199310005211 active site 199310005212 metal binding site [ion binding]; metal-binding site 199310005213 glutathione binding site [chemical binding]; other site 199310005214 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 199310005215 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 199310005216 dimer interface [polypeptide binding]; other site 199310005217 catalytic site [active] 199310005218 putative active site [active] 199310005219 putative substrate binding site [chemical binding]; other site 199310005220 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 199310005221 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 199310005222 putative GSH binding site [chemical binding]; other site 199310005223 catalytic residues [active] 199310005224 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 199310005225 NlpC/P60 family; Region: NLPC_P60; pfam00877 199310005226 superoxide dismutase; Provisional; Region: PRK10543 199310005227 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 199310005228 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 199310005229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310005231 putative substrate translocation pore; other site 199310005232 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 199310005233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310005234 DNA binding site [nucleotide binding] 199310005235 domain linker motif; other site 199310005236 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 199310005237 dimerization interface [polypeptide binding]; other site 199310005238 ligand binding site [chemical binding]; other site 199310005239 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 199310005240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310005241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310005242 dimerization interface [polypeptide binding]; other site 199310005243 putative transporter; Provisional; Region: PRK11043 199310005244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005245 putative substrate translocation pore; other site 199310005246 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 199310005247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 199310005248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310005249 S-adenosylmethionine binding site [chemical binding]; other site 199310005250 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 199310005251 Lumazine binding domain; Region: Lum_binding; pfam00677 199310005252 Lumazine binding domain; Region: Lum_binding; pfam00677 199310005253 multidrug efflux protein; Reviewed; Region: PRK01766 199310005254 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 199310005255 cation binding site [ion binding]; other site 199310005256 hypothetical protein; Provisional; Region: PRK09945 199310005257 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 199310005258 putative monooxygenase; Provisional; Region: PRK11118 199310005259 hypothetical protein; Provisional; Region: PRK09897 199310005260 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 199310005261 hypothetical protein; Provisional; Region: PRK09946 199310005262 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 199310005263 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 199310005264 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 199310005265 hypothetical protein; Provisional; Region: PRK09947 199310005266 putative oxidoreductase; Provisional; Region: PRK09849 199310005267 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 199310005268 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 199310005269 hypothetical protein; Provisional; Region: PRK09898 199310005270 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 199310005271 hypothetical protein; Provisional; Region: PRK10292 199310005272 pyruvate kinase; Provisional; Region: PRK09206 199310005273 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 199310005274 active site 199310005275 domain interfaces; other site 199310005276 murein lipoprotein; Provisional; Region: PRK15396 199310005277 L,D-transpeptidase; Provisional; Region: PRK10190 199310005278 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310005279 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 199310005280 cysteine desufuration protein SufE; Provisional; Region: PRK09296 199310005281 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 199310005282 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 199310005283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 199310005284 catalytic residue [active] 199310005285 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 199310005286 FeS assembly protein SufD; Region: sufD; TIGR01981 199310005287 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 199310005288 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 199310005289 Walker A/P-loop; other site 199310005290 ATP binding site [chemical binding]; other site 199310005291 Q-loop/lid; other site 199310005292 ABC transporter signature motif; other site 199310005293 Walker B; other site 199310005294 D-loop; other site 199310005295 H-loop/switch region; other site 199310005296 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 199310005297 putative ABC transporter; Region: ycf24; CHL00085 199310005298 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 199310005299 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 199310005300 CoenzymeA binding site [chemical binding]; other site 199310005301 subunit interaction site [polypeptide binding]; other site 199310005302 PHB binding site; other site 199310005303 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 199310005304 FAD binding domain; Region: FAD_binding_4; pfam01565 199310005305 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 199310005306 putative inner membrane protein; Provisional; Region: PRK10983 199310005307 Domain of unknown function DUF20; Region: UPF0118; pfam01594 199310005308 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 199310005309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310005311 putative substrate translocation pore; other site 199310005312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005313 putative substrate translocation pore; other site 199310005314 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 199310005315 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 199310005316 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 199310005317 shikimate binding site; other site 199310005318 NAD(P) binding site [chemical binding]; other site 199310005319 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 199310005320 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 199310005321 active site 199310005322 catalytic residue [active] 199310005323 dimer interface [polypeptide binding]; other site 199310005324 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 199310005325 Coenzyme A transferase; Region: CoA_trans; smart00882 199310005326 Coenzyme A transferase; Region: CoA_trans; cl17247 199310005327 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 199310005328 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 199310005329 active site 199310005330 Cupin domain; Region: Cupin_2; pfam07883 199310005331 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 199310005332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310005333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310005334 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 199310005335 Ligand binding site [chemical binding]; other site 199310005336 Electron transfer flavoprotein domain; Region: ETF; pfam01012 199310005337 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 199310005338 Electron transfer flavoprotein domain; Region: ETF; smart00893 199310005339 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 199310005340 oxidoreductase; Provisional; Region: PRK10015 199310005341 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 199310005342 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 199310005343 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 199310005344 acyl-activating enzyme (AAE) consensus motif; other site 199310005345 putative AMP binding site [chemical binding]; other site 199310005346 putative active site [active] 199310005347 putative CoA binding site [chemical binding]; other site 199310005348 phosphoenolpyruvate synthase; Validated; Region: PRK06464 199310005349 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 199310005350 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 199310005351 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 199310005352 PEP synthetase regulatory protein; Provisional; Region: PRK05339 199310005353 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 199310005354 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 199310005355 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 199310005356 Uncharacterized conserved protein [Function unknown]; Region: COG0397 199310005357 hypothetical protein; Validated; Region: PRK00029 199310005358 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 199310005359 NlpC/P60 family; Region: NLPC_P60; pfam00877 199310005360 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 199310005361 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310005362 Walker A/P-loop; other site 199310005363 ATP binding site [chemical binding]; other site 199310005364 Q-loop/lid; other site 199310005365 ABC transporter signature motif; other site 199310005366 Walker B; other site 199310005367 D-loop; other site 199310005368 H-loop/switch region; other site 199310005369 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 199310005370 catalytic residues [active] 199310005371 dimer interface [polypeptide binding]; other site 199310005372 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 199310005373 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310005374 ABC-ATPase subunit interface; other site 199310005375 dimer interface [polypeptide binding]; other site 199310005376 putative PBP binding regions; other site 199310005377 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 199310005378 IHF dimer interface [polypeptide binding]; other site 199310005379 IHF - DNA interface [nucleotide binding]; other site 199310005380 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 199310005381 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 199310005382 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 199310005383 dimer interface [polypeptide binding]; other site 199310005384 motif 1; other site 199310005385 active site 199310005386 motif 2; other site 199310005387 motif 3; other site 199310005388 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 199310005389 23S rRNA binding site [nucleotide binding]; other site 199310005390 L21 binding site [polypeptide binding]; other site 199310005391 L13 binding site [polypeptide binding]; other site 199310005392 carbamoyl-phosphate synthase (glutamine-hydrolyzing); Region: PLN02771 199310005393 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 199310005394 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 199310005395 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 199310005396 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 199310005397 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 199310005398 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 199310005399 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 199310005400 active site 199310005401 dimer interface [polypeptide binding]; other site 199310005402 motif 1; other site 199310005403 motif 2; other site 199310005404 motif 3; other site 199310005405 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 199310005406 anticodon binding site; other site 199310005407 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 199310005408 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 199310005409 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 199310005410 6-phosphofructokinase 2; Provisional; Region: PRK10294 199310005411 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 199310005412 putative substrate binding site [chemical binding]; other site 199310005413 putative ATP binding site [chemical binding]; other site 199310005414 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 199310005415 Phosphotransferase enzyme family; Region: APH; pfam01636 199310005416 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 199310005417 active site 199310005418 ATP binding site [chemical binding]; other site 199310005419 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 199310005420 YniB-like protein; Region: YniB; pfam14002 199310005421 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 199310005422 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 199310005423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310005424 motif II; other site 199310005425 inner membrane protein; Provisional; Region: PRK11648 199310005426 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 199310005427 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 199310005428 cell division modulator; Provisional; Region: PRK10113 199310005429 hydroperoxidase II; Provisional; Region: katE; PRK11249 199310005430 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 199310005431 tetramer interface [polypeptide binding]; other site 199310005432 heme binding pocket [chemical binding]; other site 199310005433 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 199310005434 domain interactions; other site 199310005435 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 199310005436 putative active site [active] 199310005437 YdjC motif; other site 199310005438 Mg binding site [ion binding]; other site 199310005439 putative homodimer interface [polypeptide binding]; other site 199310005440 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 199310005441 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 199310005442 NAD binding site [chemical binding]; other site 199310005443 sugar binding site [chemical binding]; other site 199310005444 divalent metal binding site [ion binding]; other site 199310005445 tetramer (dimer of dimers) interface [polypeptide binding]; other site 199310005446 dimer interface [polypeptide binding]; other site 199310005447 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 199310005448 Cupin domain; Region: Cupin_2; pfam07883 199310005449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310005450 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 199310005451 methionine cluster; other site 199310005452 active site 199310005453 phosphorylation site [posttranslational modification] 199310005454 metal binding site [ion binding]; metal-binding site 199310005455 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 199310005456 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 199310005457 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 199310005458 active site 199310005459 P-loop; other site 199310005460 phosphorylation site [posttranslational modification] 199310005461 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 199310005462 NAD+ synthetase; Region: nadE; TIGR00552 199310005463 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 199310005464 homodimer interface [polypeptide binding]; other site 199310005465 NAD binding pocket [chemical binding]; other site 199310005466 ATP binding pocket [chemical binding]; other site 199310005467 Mg binding site [ion binding]; other site 199310005468 active-site loop [active] 199310005469 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 199310005470 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 199310005471 GIY-YIG motif/motif A; other site 199310005472 active site 199310005473 catalytic site [active] 199310005474 putative DNA binding site [nucleotide binding]; other site 199310005475 metal binding site [ion binding]; metal-binding site 199310005476 hypothetical protein; Provisional; Region: PRK11396 199310005477 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 199310005478 dimer interface [polypeptide binding]; other site 199310005479 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 199310005480 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 199310005481 putative active site [active] 199310005482 Zn binding site [ion binding]; other site 199310005483 succinylarginine dihydrolase; Provisional; Region: PRK13281 199310005484 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 199310005485 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 199310005486 NAD(P) binding site [chemical binding]; other site 199310005487 catalytic residues [active] 199310005488 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 199310005489 arginine succinyltransferase; Provisional; Region: PRK10456 199310005490 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 199310005491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 199310005492 inhibitor-cofactor binding pocket; inhibition site 199310005493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310005494 catalytic residue [active] 199310005495 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 199310005496 putative catalytic site [active] 199310005497 putative phosphate binding site [ion binding]; other site 199310005498 active site 199310005499 metal binding site A [ion binding]; metal-binding site 199310005500 DNA binding site [nucleotide binding] 199310005501 putative AP binding site [nucleotide binding]; other site 199310005502 putative metal binding site B [ion binding]; other site 199310005503 Uncharacterized conserved protein [Function unknown]; Region: COG0398 199310005504 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 199310005505 Uncharacterized conserved protein [Function unknown]; Region: COG0398 199310005506 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 199310005507 Uncharacterized conserved protein [Function unknown]; Region: COG2128 199310005508 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 199310005509 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 199310005510 hypothetical protein; Provisional; Region: PRK11622 199310005511 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 199310005512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310005513 dimer interface [polypeptide binding]; other site 199310005514 conserved gate region; other site 199310005515 putative PBP binding loops; other site 199310005516 ABC-ATPase subunit interface; other site 199310005517 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 199310005518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310005519 Walker A/P-loop; other site 199310005520 ATP binding site [chemical binding]; other site 199310005521 Q-loop/lid; other site 199310005522 ABC transporter signature motif; other site 199310005523 Walker B; other site 199310005524 D-loop; other site 199310005525 H-loop/switch region; other site 199310005526 Rhodanese Homology Domain; Region: RHOD; smart00450 199310005527 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 199310005528 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 199310005529 active site residue [active] 199310005530 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 199310005531 active site residue [active] 199310005532 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 199310005533 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 199310005534 active site 199310005535 8-oxo-dGMP binding site [chemical binding]; other site 199310005536 nudix motif; other site 199310005537 metal binding site [ion binding]; metal-binding site 199310005538 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 199310005539 glutamate dehydrogenase; Provisional; Region: PRK09414 199310005540 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 199310005541 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 199310005542 NAD(P) binding site [chemical binding]; other site 199310005543 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 199310005544 HSP70 interaction site [polypeptide binding]; other site 199310005545 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 199310005546 Sel1-like repeats; Region: SEL1; smart00671 199310005547 Sel1-like repeats; Region: SEL1; smart00671 199310005548 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 199310005549 Sel1-like repeats; Region: SEL1; smart00671 199310005550 Sel1-like repeats; Region: SEL1; smart00671 199310005551 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 199310005552 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 199310005553 nucleotide binding site [chemical binding]; other site 199310005554 putative NEF/HSP70 interaction site [polypeptide binding]; other site 199310005555 SBD interface [polypeptide binding]; other site 199310005556 DNA topoisomerase III; Provisional; Region: PRK07726 199310005557 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 199310005558 active site 199310005559 putative interdomain interaction site [polypeptide binding]; other site 199310005560 putative metal-binding site [ion binding]; other site 199310005561 putative nucleotide binding site [chemical binding]; other site 199310005562 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 199310005563 domain I; other site 199310005564 DNA binding groove [nucleotide binding] 199310005565 phosphate binding site [ion binding]; other site 199310005566 domain II; other site 199310005567 domain III; other site 199310005568 nucleotide binding site [chemical binding]; other site 199310005569 catalytic site [active] 199310005570 domain IV; other site 199310005571 selenophosphate synthetase; Provisional; Region: PRK00943 199310005572 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 199310005573 dimerization interface [polypeptide binding]; other site 199310005574 putative ATP binding site [chemical binding]; other site 199310005575 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 199310005576 putative FMN binding site [chemical binding]; other site 199310005577 protease 4; Provisional; Region: PRK10949 199310005578 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 199310005579 tandem repeat interface [polypeptide binding]; other site 199310005580 oligomer interface [polypeptide binding]; other site 199310005581 active site residues [active] 199310005582 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 199310005583 tandem repeat interface [polypeptide binding]; other site 199310005584 oligomer interface [polypeptide binding]; other site 199310005585 active site residues [active] 199310005586 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 199310005587 active site 199310005588 homodimer interface [polypeptide binding]; other site 199310005589 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 199310005590 Isochorismatase family; Region: Isochorismatase; pfam00857 199310005591 catalytic triad [active] 199310005592 metal binding site [ion binding]; metal-binding site 199310005593 conserved cis-peptide bond; other site 199310005594 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 199310005595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005596 putative substrate translocation pore; other site 199310005597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005598 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310005599 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 199310005600 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310005601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310005602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310005603 active site 199310005604 catalytic tetrad [active] 199310005605 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310005606 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 199310005607 substrate binding site [chemical binding]; other site 199310005608 ATP binding site [chemical binding]; other site 199310005609 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 199310005610 intersubunit interface [polypeptide binding]; other site 199310005611 active site 199310005612 zinc binding site [ion binding]; other site 199310005613 Na+ binding site [ion binding]; other site 199310005614 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310005615 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 199310005616 inhibitor binding site; inhibition site 199310005617 catalytic Zn binding site [ion binding]; other site 199310005618 structural Zn binding site [ion binding]; other site 199310005619 NADP binding site [chemical binding]; other site 199310005620 tetramer interface [polypeptide binding]; other site 199310005621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005623 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310005624 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 199310005625 putative NAD(P) binding site [chemical binding]; other site 199310005626 catalytic Zn binding site [ion binding]; other site 199310005627 structural Zn binding site [ion binding]; other site 199310005628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 199310005629 methionine sulfoxide reductase B; Provisional; Region: PRK00222 199310005630 SelR domain; Region: SelR; pfam01641 199310005631 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 199310005632 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 199310005633 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 199310005634 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 199310005635 active site 199310005636 phosphate binding residues; other site 199310005637 catalytic residues [active] 199310005638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310005639 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310005640 active site 199310005641 catalytic tetrad [active] 199310005642 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 199310005643 PrkA family serine protein kinase; Provisional; Region: PRK15455 199310005644 AAA ATPase domain; Region: AAA_16; pfam13191 199310005645 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 199310005646 hypothetical protein; Provisional; Region: PRK05325 199310005647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310005648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310005649 metal binding site [ion binding]; metal-binding site 199310005650 active site 199310005651 I-site; other site 199310005652 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310005653 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310005654 metal binding site [ion binding]; metal-binding site 199310005655 active site 199310005656 I-site; other site 199310005657 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 199310005658 putative deacylase active site [active] 199310005659 Predicted membrane protein [Function unknown]; Region: COG2707 199310005660 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310005661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310005662 cyanate transporter; Region: CynX; TIGR00896 199310005663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005664 Uncharacterized conserved protein [Function unknown]; Region: COG3189 199310005665 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 199310005666 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 199310005667 Domain of unknown function (DUF333); Region: DUF333; pfam03891 199310005668 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 199310005669 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 199310005670 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310005671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310005672 metal binding site [ion binding]; metal-binding site 199310005673 active site 199310005674 I-site; other site 199310005675 hypothetical protein; Provisional; Region: PRK10457 199310005676 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 199310005677 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 199310005678 leucine export protein LeuE; Provisional; Region: PRK10958 199310005679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310005680 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 199310005681 ribonuclease D; Provisional; Region: PRK10829 199310005682 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 199310005683 catalytic site [active] 199310005684 putative active site [active] 199310005685 putative substrate binding site [chemical binding]; other site 199310005686 Helicase and RNase D C-terminal; Region: HRDC; smart00341 199310005687 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 199310005688 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 199310005689 acyl-activating enzyme (AAE) consensus motif; other site 199310005690 putative AMP binding site [chemical binding]; other site 199310005691 putative active site [active] 199310005692 putative CoA binding site [chemical binding]; other site 199310005693 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 199310005694 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 199310005695 Glycoprotease family; Region: Peptidase_M22; pfam00814 199310005696 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 199310005697 DEAD/DEAH box helicase; Region: DEAD; pfam00270 199310005698 DEAD_2; Region: DEAD_2; pfam06733 199310005699 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 199310005700 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 199310005701 homotrimer interaction site [polypeptide binding]; other site 199310005702 putative active site [active] 199310005703 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 199310005704 hypothetical protein; Provisional; Region: PRK05114 199310005705 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 199310005706 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 199310005707 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 199310005708 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 199310005709 putative active site [active] 199310005710 putative CoA binding site [chemical binding]; other site 199310005711 nudix motif; other site 199310005712 metal binding site [ion binding]; metal-binding site 199310005713 L-serine deaminase; Provisional; Region: PRK15023 199310005714 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 199310005715 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 199310005716 phage resistance protein; Provisional; Region: PRK10551 199310005717 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 199310005718 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310005719 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 199310005720 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 199310005721 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 199310005722 Transporter associated domain; Region: CorC_HlyC; smart01091 199310005723 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 199310005724 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 199310005725 active pocket/dimerization site; other site 199310005726 active site 199310005727 phosphorylation site [posttranslational modification] 199310005728 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 199310005729 active site 199310005730 phosphorylation site [posttranslational modification] 199310005731 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 199310005732 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 199310005733 Predicted membrane protein [Function unknown]; Region: COG4811 199310005734 hypothetical protein; Provisional; Region: PRK11469 199310005735 Domain of unknown function DUF; Region: DUF204; pfam02659 199310005736 Domain of unknown function DUF; Region: DUF204; pfam02659 199310005737 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 199310005738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310005739 S-adenosylmethionine binding site [chemical binding]; other site 199310005740 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310005741 DNA-binding site [nucleotide binding]; DNA binding site 199310005742 RNA-binding motif; other site 199310005743 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 199310005744 YebO-like protein; Region: YebO; pfam13974 199310005745 PhoPQ regulatory protein; Provisional; Region: PRK10299 199310005746 YobH-like protein; Region: YobH; pfam13996 199310005747 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 199310005748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 199310005749 dimerization interface [polypeptide binding]; other site 199310005750 putative Zn2+ binding site [ion binding]; other site 199310005751 putative DNA binding site [nucleotide binding]; other site 199310005752 Bacterial transcriptional regulator; Region: IclR; pfam01614 199310005753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310005754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310005755 putative substrate translocation pore; other site 199310005756 Predicted integral membrane protein [Function unknown]; Region: COG5521 199310005757 heat shock protein HtpX; Provisional; Region: PRK05457 199310005758 carboxy-terminal protease; Provisional; Region: PRK11186 199310005759 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 199310005760 protein binding site [polypeptide binding]; other site 199310005761 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 199310005762 Catalytic dyad [active] 199310005763 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 199310005764 ProP expression regulator; Provisional; Region: PRK04950 199310005765 ProQ/FINO family; Region: ProQ; pfam04352 199310005766 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 199310005767 GAF domain; Region: GAF_2; pfam13185 199310005768 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 199310005769 Paraquat-inducible protein A; Region: PqiA; pfam04403 199310005770 Paraquat-inducible protein A; Region: PqiA; pfam04403 199310005771 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 199310005772 mce related protein; Region: MCE; pfam02470 199310005773 mce related protein; Region: MCE; pfam02470 199310005774 mce related protein; Region: MCE; pfam02470 199310005775 mce related protein; Region: MCE; pfam02470 199310005776 mce related protein; Region: MCE; pfam02470 199310005777 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 199310005778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310005779 S-adenosylmethionine binding site [chemical binding]; other site 199310005780 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 199310005781 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 199310005782 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 199310005783 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 199310005784 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 199310005785 active site 199310005786 metal binding site [ion binding]; metal-binding site 199310005787 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 199310005788 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 199310005789 hypothetical protein; Provisional; Region: PRK10301 199310005790 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 199310005791 Predicted amidohydrolase [General function prediction only]; Region: COG0388 199310005792 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 199310005793 exodeoxyribonuclease X; Provisional; Region: PRK07983 199310005794 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 199310005795 active site 199310005796 catalytic site [active] 199310005797 substrate binding site [chemical binding]; other site 199310005798 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310005799 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 199310005800 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 199310005802 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 199310005803 putative metal binding site [ion binding]; other site 199310005804 hypothetical protein; Provisional; Region: PRK13680 199310005805 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 199310005806 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 199310005807 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 199310005808 active site 199310005809 intersubunit interface [polypeptide binding]; other site 199310005810 catalytic residue [active] 199310005811 phosphogluconate dehydratase; Validated; Region: PRK09054 199310005812 6-phosphogluconate dehydratase; Region: edd; TIGR01196 199310005813 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 199310005814 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 199310005815 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 199310005816 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 199310005817 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 199310005818 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 199310005819 putative active site [active] 199310005820 pyruvate kinase; Provisional; Region: PRK05826 199310005821 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 199310005822 domain interfaces; other site 199310005823 active site 199310005824 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 199310005825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 199310005826 putative acyl-acceptor binding pocket; other site 199310005827 putative peptidase; Provisional; Region: PRK11649 199310005828 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 199310005829 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310005830 Peptidase family M23; Region: Peptidase_M23; pfam01551 199310005831 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 199310005832 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 199310005833 metal binding site [ion binding]; metal-binding site 199310005834 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 199310005835 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 199310005836 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 199310005837 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310005838 ABC-ATPase subunit interface; other site 199310005839 dimer interface [polypeptide binding]; other site 199310005840 putative PBP binding regions; other site 199310005841 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 199310005842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310005843 Walker A motif; other site 199310005844 ATP binding site [chemical binding]; other site 199310005845 Walker B motif; other site 199310005846 arginine finger; other site 199310005847 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 199310005848 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 199310005849 RuvA N terminal domain; Region: RuvA_N; pfam01330 199310005850 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 199310005851 hypothetical protein; Provisional; Region: PRK11470 199310005852 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 199310005853 active site 199310005854 putative DNA-binding cleft [nucleotide binding]; other site 199310005855 dimer interface [polypeptide binding]; other site 199310005856 hypothetical protein; Validated; Region: PRK00110 199310005857 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 199310005858 nudix motif; other site 199310005859 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 199310005860 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 199310005861 dimer interface [polypeptide binding]; other site 199310005862 anticodon binding site; other site 199310005863 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 199310005864 homodimer interface [polypeptide binding]; other site 199310005865 motif 1; other site 199310005866 active site 199310005867 motif 2; other site 199310005868 GAD domain; Region: GAD; pfam02938 199310005869 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 199310005870 motif 3; other site 199310005871 Isochorismatase family; Region: Isochorismatase; pfam00857 199310005872 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 199310005873 catalytic triad [active] 199310005874 conserved cis-peptide bond; other site 199310005875 hypothetical protein; Provisional; Region: PRK10302 199310005876 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 199310005877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310005878 S-adenosylmethionine binding site [chemical binding]; other site 199310005879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310005880 S-adenosylmethionine binding site [chemical binding]; other site 199310005881 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 199310005882 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 199310005883 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 199310005884 molybdopterin cofactor binding site [chemical binding]; other site 199310005885 substrate binding site [chemical binding]; other site 199310005886 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 199310005887 molybdopterin cofactor binding site; other site 199310005888 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 199310005889 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 199310005890 copper homeostasis protein CutC; Provisional; Region: PRK11572 199310005891 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 199310005892 putative metal binding site [ion binding]; other site 199310005893 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 199310005894 arginyl-tRNA synthetase; Region: argS; TIGR00456 199310005895 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 199310005896 active site 199310005897 HIGH motif; other site 199310005898 KMSK motif region; other site 199310005899 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 199310005900 tRNA binding surface [nucleotide binding]; other site 199310005901 anticodon binding site; other site 199310005902 Flagellar protein FlhE; Region: FlhE; pfam06366 199310005903 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 199310005904 FHIPEP family; Region: FHIPEP; pfam00771 199310005905 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 199310005906 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 199310005907 chemotaxis regulator CheZ; Provisional; Region: PRK11166 199310005908 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 199310005909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310005910 active site 199310005911 phosphorylation site [posttranslational modification] 199310005912 intermolecular recognition site; other site 199310005913 dimerization interface [polypeptide binding]; other site 199310005914 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 199310005915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310005916 active site 199310005917 phosphorylation site [posttranslational modification] 199310005918 intermolecular recognition site; other site 199310005919 dimerization interface [polypeptide binding]; other site 199310005920 CheB methylesterase; Region: CheB_methylest; pfam01339 199310005921 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 199310005922 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 199310005923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310005924 S-adenosylmethionine binding site [chemical binding]; other site 199310005925 methyl-accepting protein IV; Provisional; Region: PRK09793 199310005926 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 199310005927 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 199310005928 dimer interface [polypeptide binding]; other site 199310005929 ligand binding site [chemical binding]; other site 199310005930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310005931 dimerization interface [polypeptide binding]; other site 199310005932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 199310005933 dimer interface [polypeptide binding]; other site 199310005934 putative CheW interface [polypeptide binding]; other site 199310005935 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 199310005936 putative CheA interaction surface; other site 199310005937 chemotaxis protein CheA; Provisional; Region: PRK10547 199310005938 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 199310005939 putative binding surface; other site 199310005940 active site 199310005941 CheY binding; Region: CheY-binding; pfam09078 199310005942 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 199310005943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310005944 ATP binding site [chemical binding]; other site 199310005945 Mg2+ binding site [ion binding]; other site 199310005946 G-X-G motif; other site 199310005947 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 199310005948 flagellar motor protein MotB; Validated; Region: motB; PRK09041 199310005949 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 199310005950 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 199310005951 ligand binding site [chemical binding]; other site 199310005952 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 199310005953 flagellar motor protein MotA; Validated; Region: PRK09110 199310005954 transcriptional activator FlhC; Provisional; Region: PRK12722 199310005955 transcriptional activator FlhD; Provisional; Region: PRK02909 199310005956 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 199310005957 Ligand Binding Site [chemical binding]; other site 199310005958 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 199310005959 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 199310005960 active site 199310005961 homotetramer interface [polypeptide binding]; other site 199310005962 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 199310005963 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 199310005964 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310005965 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310005966 TM-ABC transporter signature motif; other site 199310005967 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 199310005968 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 199310005969 Walker A/P-loop; other site 199310005970 ATP binding site [chemical binding]; other site 199310005971 Q-loop/lid; other site 199310005972 ABC transporter signature motif; other site 199310005973 Walker B; other site 199310005974 D-loop; other site 199310005975 H-loop/switch region; other site 199310005976 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310005977 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 199310005978 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 199310005979 ligand binding site [chemical binding]; other site 199310005980 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 199310005981 Ferritin-like domain; Region: Ferritin; pfam00210 199310005982 ferroxidase diiron center [ion binding]; other site 199310005983 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 199310005984 YecR-like lipoprotein; Region: YecR; pfam13992 199310005985 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 199310005986 Ferritin-like domain; Region: Ferritin; pfam00210 199310005987 ferroxidase diiron center [ion binding]; other site 199310005988 probable metal-binding protein; Region: matur_matur; TIGR03853 199310005989 tyrosine transporter TyrP; Provisional; Region: PRK15132 199310005990 aromatic amino acid transport protein; Region: araaP; TIGR00837 199310005991 hypothetical protein; Provisional; Region: PRK10396 199310005992 yecA family protein; Region: ygfB_yecA; TIGR02292 199310005993 SEC-C motif; Region: SEC-C; pfam02810 199310005994 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 199310005995 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 199310005996 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 199310005997 GIY-YIG motif/motif A; other site 199310005998 active site 199310005999 catalytic site [active] 199310006000 putative DNA binding site [nucleotide binding]; other site 199310006001 metal binding site [ion binding]; metal-binding site 199310006002 UvrB/uvrC motif; Region: UVR; pfam02151 199310006003 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 199310006004 Helix-hairpin-helix motif; Region: HHH; pfam00633 199310006005 response regulator; Provisional; Region: PRK09483 199310006006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310006007 active site 199310006008 phosphorylation site [posttranslational modification] 199310006009 intermolecular recognition site; other site 199310006010 dimerization interface [polypeptide binding]; other site 199310006011 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310006012 DNA binding residues [nucleotide binding] 199310006013 dimerization interface [polypeptide binding]; other site 199310006014 hypothetical protein; Provisional; Region: PRK10613 199310006015 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 199310006016 Autoinducer binding domain; Region: Autoind_bind; pfam03472 199310006017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310006018 DNA binding residues [nucleotide binding] 199310006019 dimerization interface [polypeptide binding]; other site 199310006020 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 199310006021 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 199310006022 Walker A/P-loop; other site 199310006023 ATP binding site [chemical binding]; other site 199310006024 Q-loop/lid; other site 199310006025 ABC transporter signature motif; other site 199310006026 Walker B; other site 199310006027 D-loop; other site 199310006028 H-loop/switch region; other site 199310006029 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 199310006030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310006031 dimer interface [polypeptide binding]; other site 199310006032 conserved gate region; other site 199310006033 putative PBP binding loops; other site 199310006034 ABC-ATPase subunit interface; other site 199310006035 D-cysteine desulfhydrase; Validated; Region: PRK03910 199310006036 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 199310006037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310006038 catalytic residue [active] 199310006039 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310006040 cystine transporter subunit; Provisional; Region: PRK11260 199310006041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310006042 substrate binding pocket [chemical binding]; other site 199310006043 membrane-bound complex binding site; other site 199310006044 hinge residues; other site 199310006045 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 199310006046 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 199310006047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 199310006048 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 199310006049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 199310006050 DNA binding residues [nucleotide binding] 199310006051 flagellin; Validated; Region: PRK08026 199310006052 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 199310006053 Flagellin protein; Region: FliC; pfam12445 199310006054 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 199310006055 flagellar capping protein; Reviewed; Region: fliD; PRK08032 199310006056 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 199310006057 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 199310006058 Flagellar protein FliS; Region: FliS; cl00654 199310006059 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 199310006060 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 199310006061 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 199310006062 active site 199310006063 Na/Ca binding site [ion binding]; other site 199310006064 catalytic site [active] 199310006065 lipoprotein; Provisional; Region: PRK10397 199310006066 putative inner membrane protein; Provisional; Region: PRK11099 199310006067 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 199310006068 CPxP motif; other site 199310006069 hypothetical protein; Provisional; Region: PRK09951 199310006070 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 199310006071 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 199310006072 trimer interface [polypeptide binding]; other site 199310006073 eyelet of channel; other site 199310006074 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310006075 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 199310006076 substrate binding site [chemical binding]; other site 199310006077 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 199310006078 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 199310006079 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 199310006080 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 199310006081 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 199310006082 flagellar motor switch protein FliG; Region: fliG; TIGR00207 199310006083 FliG C-terminal domain; Region: FliG_C; pfam01706 199310006084 flagellar assembly protein H; Validated; Region: fliH; PRK05687 199310006085 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 199310006086 Flagellar assembly protein FliH; Region: FliH; pfam02108 199310006087 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 199310006088 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 199310006089 Walker A motif/ATP binding site; other site 199310006090 Walker B motif; other site 199310006091 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 199310006092 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 199310006093 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 199310006094 flagellar hook-length control protein; Provisional; Region: PRK10118 199310006095 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 199310006096 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 199310006097 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 199310006098 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 199310006099 flagellar motor switch protein; Validated; Region: fliN; PRK05698 199310006100 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 199310006101 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 199310006102 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 199310006103 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 199310006104 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 199310006105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310006106 DNA binding residues [nucleotide binding] 199310006107 dimerization interface [polypeptide binding]; other site 199310006108 hypothetical protein; Provisional; Region: PRK10708 199310006109 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 199310006110 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 199310006111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310006112 active site 199310006113 motif I; other site 199310006114 motif II; other site 199310006115 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 199310006116 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310006117 metal binding site [ion binding]; metal-binding site 199310006118 active site 199310006119 I-site; other site 199310006120 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 199310006121 hypothetical protein; Provisional; Region: PRK10062 199310006122 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 199310006123 EamA-like transporter family; Region: EamA; pfam00892 199310006124 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 199310006125 additional DNA contacts [nucleotide binding]; other site 199310006126 mismatch recognition site; other site 199310006127 active site 199310006128 zinc binding site [ion binding]; other site 199310006129 DNA intercalation site [nucleotide binding]; other site 199310006130 DNA cytosine methylase; Provisional; Region: PRK10458 199310006131 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 199310006132 cofactor binding site; other site 199310006133 DNA binding site [nucleotide binding] 199310006134 substrate interaction site [chemical binding]; other site 199310006135 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 199310006136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 199310006137 Zn2+ binding site [ion binding]; other site 199310006138 Mg2+ binding site [ion binding]; other site 199310006139 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 199310006140 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 199310006141 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 199310006142 trimer interface [polypeptide binding]; other site 199310006143 eyelet of channel; other site 199310006144 chaperone protein HchA; Provisional; Region: PRK04155 199310006145 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 199310006146 dimer interface [polypeptide binding]; other site 199310006147 metal binding site [ion binding]; metal-binding site 199310006148 potential oxyanion hole; other site 199310006149 potential catalytic triad [active] 199310006150 conserved cys residue [active] 199310006151 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 199310006152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310006153 dimer interface [polypeptide binding]; other site 199310006154 phosphorylation site [posttranslational modification] 199310006155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310006156 ATP binding site [chemical binding]; other site 199310006157 Mg2+ binding site [ion binding]; other site 199310006158 G-X-G motif; other site 199310006159 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 199310006160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310006161 active site 199310006162 phosphorylation site [posttranslational modification] 199310006163 intermolecular recognition site; other site 199310006164 dimerization interface [polypeptide binding]; other site 199310006165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310006166 DNA binding site [nucleotide binding] 199310006167 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 199310006168 active site 199310006169 homotetramer interface [polypeptide binding]; other site 199310006170 TMAO/DMSO reductase; Reviewed; Region: PRK05363 199310006171 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 199310006172 Moco binding site; other site 199310006173 metal coordination site [ion binding]; other site 199310006174 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 199310006175 zinc/cadmium-binding protein; Provisional; Region: PRK10306 199310006176 integrase; Provisional; Region: PRK09692 199310006177 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310006178 active site 199310006179 Int/Topo IB signature motif; other site 199310006180 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 199310006181 PilS N terminal; Region: PilS; pfam08805 199310006182 Conjugal transfer protein TraD; Region: TraD; pfam06412 199310006183 MobA/MobL family; Region: MobA_MobL; pfam03389 199310006184 TIR domain; Region: TIR_2; pfam13676 199310006185 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 199310006186 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 199310006187 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 199310006188 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 199310006189 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 199310006190 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 199310006191 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 199310006192 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310006193 active site 199310006194 Int/Topo IB signature motif; other site 199310006195 salicylate synthase Irp9; Reviewed; Region: PRK06772 199310006196 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 199310006197 muropeptide transporter; Validated; Region: ampG; cl17669 199310006198 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 199310006199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310006200 Walker A/P-loop; other site 199310006201 ATP binding site [chemical binding]; other site 199310006202 Q-loop/lid; other site 199310006203 ABC transporter signature motif; other site 199310006204 Walker B; other site 199310006205 D-loop; other site 199310006206 H-loop/switch region; other site 199310006207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310006208 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 199310006209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310006210 Walker A/P-loop; other site 199310006211 ATP binding site [chemical binding]; other site 199310006212 Q-loop/lid; other site 199310006213 ABC transporter signature motif; other site 199310006214 Walker B; other site 199310006215 D-loop; other site 199310006216 H-loop/switch region; other site 199310006217 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310006218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310006219 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 199310006220 Condensation domain; Region: Condensation; pfam00668 199310006221 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006222 Nonribosomal peptide synthase; Region: NRPS; pfam08415 199310006223 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 199310006224 acyl-activating enzyme (AAE) consensus motif; other site 199310006225 AMP binding site [chemical binding]; other site 199310006226 Methyltransferase domain; Region: Methyltransf_23; pfam13489 199310006227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310006228 S-adenosylmethionine binding site [chemical binding]; other site 199310006229 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 199310006230 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310006231 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006232 Condensation domain; Region: Condensation; pfam00668 199310006233 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006234 Nonribosomal peptide synthase; Region: NRPS; pfam08415 199310006235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006236 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 199310006237 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 199310006238 active site 199310006239 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 199310006240 Acyl transferase domain; Region: Acyl_transf_1; cl08282 199310006241 Methyltransferase domain; Region: Methyltransf_12; pfam08242 199310006242 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 199310006243 NADP binding site [chemical binding]; other site 199310006244 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 199310006245 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 199310006246 active site 199310006247 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006248 Condensation domain; Region: Condensation; pfam00668 199310006249 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006250 Nonribosomal peptide synthase; Region: NRPS; pfam08415 199310006251 Methyltransferase domain; Region: Methyltransf_12; pfam08242 199310006252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006253 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 199310006254 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 199310006255 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 199310006256 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 199310006257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 199310006258 AMP-binding enzyme; Region: AMP-binding; pfam00501 199310006259 acyl-activating enzyme (AAE) consensus motif; other site 199310006260 active site 199310006261 AMP binding site [chemical binding]; other site 199310006262 CoA binding site [chemical binding]; other site 199310006263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 199310006264 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 199310006265 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310006266 N-terminal plug; other site 199310006267 ligand-binding site [chemical binding]; other site 199310006268 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 199310006269 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 199310006270 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 199310006271 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 199310006272 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 199310006273 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 199310006274 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 199310006275 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 199310006276 shikimate transporter; Provisional; Region: PRK09952 199310006277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310006278 putative substrate translocation pore; other site 199310006279 AMP nucleosidase; Provisional; Region: PRK08292 199310006280 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 199310006281 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 199310006282 hypothetical protein; Provisional; Region: PRK12378 199310006283 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 199310006284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310006285 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 199310006286 putative dimerization interface [polypeptide binding]; other site 199310006287 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 199310006288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310006289 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 199310006290 putative substrate binding site [chemical binding]; other site 199310006291 dimerization interface [polypeptide binding]; other site 199310006292 MATE family multidrug exporter; Provisional; Region: PRK10189 199310006293 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 199310006294 integrase; Provisional; Region: PRK09692 199310006295 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310006296 active site 199310006297 Int/Topo IB signature motif; other site 199310006298 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 199310006299 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 199310006300 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 199310006301 Beta-lactamase; Region: Beta-lactamase; pfam00144 199310006302 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 199310006303 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 199310006304 active site 199310006305 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 199310006306 Condensation domain; Region: Condensation; pfam00668 199310006307 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 199310006308 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 199310006309 acyl-activating enzyme (AAE) consensus motif; other site 199310006310 AMP binding site [chemical binding]; other site 199310006311 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006312 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 199310006313 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 199310006314 amidase; Provisional; Region: PRK06170 199310006315 Amidase; Region: Amidase; cl11426 199310006316 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 199310006317 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 199310006318 active site 199310006319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006320 Condensation domain; Region: Condensation; pfam00668 199310006321 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006322 Nonribosomal peptide synthase; Region: NRPS; pfam08415 199310006323 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 199310006324 acyl-activating enzyme (AAE) consensus motif; other site 199310006325 AMP binding site [chemical binding]; other site 199310006326 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 199310006327 putative FMN binding site [chemical binding]; other site 199310006328 NADPH bind site [chemical binding]; other site 199310006329 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 199310006330 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006331 Condensation domain; Region: Condensation; pfam00668 199310006332 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006333 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 199310006334 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 199310006335 acyl-activating enzyme (AAE) consensus motif; other site 199310006336 AMP binding site [chemical binding]; other site 199310006337 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006338 Condensation domain; Region: Condensation; pfam00668 199310006339 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006340 Nonribosomal peptide synthase; Region: NRPS; pfam08415 199310006341 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 199310006342 acyl-activating enzyme (AAE) consensus motif; other site 199310006343 AMP binding site [chemical binding]; other site 199310006344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006345 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 199310006346 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 199310006347 active site 199310006348 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 199310006349 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 199310006350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006351 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 199310006352 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 199310006353 acyl-activating enzyme (AAE) consensus motif; other site 199310006354 AMP binding site [chemical binding]; other site 199310006355 Condensation domain; Region: Condensation; pfam00668 199310006356 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006357 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 199310006358 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 199310006359 acyl-activating enzyme (AAE) consensus motif; other site 199310006360 AMP binding site [chemical binding]; other site 199310006361 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006362 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 199310006363 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 199310006364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 199310006365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 199310006366 active site 199310006367 acyl carrier protein; Provisional; Region: PRK07081 199310006368 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 199310006369 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 199310006370 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 199310006371 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 199310006372 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 199310006373 active site 199310006374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006375 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 199310006376 KR domain; Region: KR; pfam08659 199310006377 putative NADP binding site [chemical binding]; other site 199310006378 active site 199310006379 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 199310006380 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 199310006381 Enoylreductase; Region: PKS_ER; smart00829 199310006382 NAD(P) binding site [chemical binding]; other site 199310006383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006384 Condensation domain; Region: Condensation; pfam00668 199310006385 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 199310006386 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 199310006387 acyl-activating enzyme (AAE) consensus motif; other site 199310006388 AMP binding site [chemical binding]; other site 199310006389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310006390 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 199310006391 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 199310006392 active site 199310006393 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 199310006394 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 199310006395 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 199310006396 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 199310006397 DNA-binding interface [nucleotide binding]; DNA binding site 199310006398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 199310006399 Integrase core domain; Region: rve; pfam00665 199310006400 Integrase core domain; Region: rve_3; pfam13683 199310006401 Integrase core domain; Region: rve_2; pfam13333 199310006402 L,D-transpeptidase; Provisional; Region: PRK10190 199310006403 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 199310006404 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 199310006405 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 199310006406 putative dimer interface [polypeptide binding]; other site 199310006407 active site pocket [active] 199310006408 putative cataytic base [active] 199310006409 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 199310006410 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 199310006411 homotrimer interface [polypeptide binding]; other site 199310006412 Walker A motif; other site 199310006413 GTP binding site [chemical binding]; other site 199310006414 Walker B motif; other site 199310006415 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 199310006416 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310006417 N-terminal plug; other site 199310006418 ligand-binding site [chemical binding]; other site 199310006419 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 199310006420 ParB-like nuclease domain; Region: ParBc; cl02129 199310006421 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 199310006422 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 199310006423 Active Sites [active] 199310006424 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 199310006425 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 199310006426 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 199310006427 putative trimer interface [polypeptide binding]; other site 199310006428 putative CoA binding site [chemical binding]; other site 199310006429 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310006430 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 199310006431 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310006432 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 199310006433 substrate binding site [chemical binding]; other site 199310006434 dimer interface [polypeptide binding]; other site 199310006435 ATP binding site [chemical binding]; other site 199310006436 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 199310006437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 199310006438 Protein of unknown function, DUF606; Region: DUF606; pfam04657 199310006439 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 199310006440 active site 199310006441 substrate binding pocket [chemical binding]; other site 199310006442 homodimer interaction site [polypeptide binding]; other site 199310006443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 199310006444 Transposase; Region: DDE_Tnp_ISL3; pfam01610 199310006445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 199310006446 Transposase; Region: DDE_Tnp_ISL3; pfam01610 199310006447 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 199310006448 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 199310006449 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 199310006450 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310006451 Haemolysin expression modulating protein; Region: HHA; cl11501 199310006452 Transposase; Region: DEDD_Tnp_IS110; pfam01548 199310006453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 199310006454 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 199310006455 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 199310006456 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 199310006457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310006458 Walker A motif; other site 199310006459 ATP binding site [chemical binding]; other site 199310006460 Walker B motif; other site 199310006461 transposase/IS protein; Provisional; Region: PRK09183 199310006462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310006463 Walker A motif; other site 199310006464 ATP binding site [chemical binding]; other site 199310006465 Walker B motif; other site 199310006466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 199310006467 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 199310006468 DNA-binding interface [nucleotide binding]; DNA binding site 199310006469 Integrase core domain; Region: rve; pfam00665 199310006470 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 199310006471 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310006472 Walker A/P-loop; other site 199310006473 ATP binding site [chemical binding]; other site 199310006474 Q-loop/lid; other site 199310006475 ABC transporter signature motif; other site 199310006476 Walker B; other site 199310006477 D-loop; other site 199310006478 H-loop/switch region; other site 199310006479 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310006480 dimer interface [polypeptide binding]; other site 199310006481 putative PBP binding regions; other site 199310006482 ABC-ATPase subunit interface; other site 199310006483 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 199310006484 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 199310006485 putative ligand binding residues [chemical binding]; other site 199310006486 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 199310006487 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310006488 N-terminal plug; other site 199310006489 ligand-binding site [chemical binding]; other site 199310006490 hypothetical protein; Provisional; Region: PRK09866 199310006491 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 199310006492 G1 box; other site 199310006493 GTP/Mg2+ binding site [chemical binding]; other site 199310006494 G2 box; other site 199310006495 Switch I region; other site 199310006496 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 199310006497 G3 box; other site 199310006498 Switch II region; other site 199310006499 GTP/Mg2+ binding site [chemical binding]; other site 199310006500 G4 box; other site 199310006501 G5 box; other site 199310006502 YjcZ-like protein; Region: YjcZ; pfam13990 199310006503 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 199310006504 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 199310006505 nucleophile elbow; other site 199310006506 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 199310006507 Domain of unknown function (DUF932); Region: DUF932; pfam06067 199310006508 Antirestriction protein; Region: Antirestrict; pfam03230 199310006509 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 199310006510 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 199310006511 MPN+ (JAMM) motif; other site 199310006512 Zinc-binding site [ion binding]; other site 199310006513 Protein of unknown function (DUF987); Region: DUF987; pfam06174 199310006514 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 199310006515 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 199310006516 hypothetical protein; Provisional; Region: PRK05423 199310006517 Predicted membrane protein [Function unknown]; Region: COG1289 199310006518 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 199310006519 DNA gyrase inhibitor; Provisional; Region: PRK10016 199310006520 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 199310006521 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 199310006522 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 199310006523 exonuclease I; Provisional; Region: sbcB; PRK11779 199310006524 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 199310006525 active site 199310006526 catalytic site [active] 199310006527 substrate binding site [chemical binding]; other site 199310006528 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 199310006529 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 199310006530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310006531 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 199310006532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310006533 dimerization interface [polypeptide binding]; other site 199310006534 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 199310006535 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 199310006536 putative NAD(P) binding site [chemical binding]; other site 199310006537 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 199310006538 antitoxin YefM; Provisional; Region: PRK11409 199310006539 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 199310006540 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 199310006541 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 199310006542 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 199310006543 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 199310006544 NAD binding site [chemical binding]; other site 199310006545 dimerization interface [polypeptide binding]; other site 199310006546 product binding site; other site 199310006547 substrate binding site [chemical binding]; other site 199310006548 zinc binding site [ion binding]; other site 199310006549 catalytic residues [active] 199310006550 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 199310006551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310006552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310006553 homodimer interface [polypeptide binding]; other site 199310006554 catalytic residue [active] 199310006555 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 199310006556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310006557 active site 199310006558 motif I; other site 199310006559 motif II; other site 199310006560 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 199310006561 putative active site pocket [active] 199310006562 4-fold oligomerization interface [polypeptide binding]; other site 199310006563 metal binding residues [ion binding]; metal-binding site 199310006564 3-fold/trimer interface [polypeptide binding]; other site 199310006565 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 199310006566 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 199310006567 putative active site [active] 199310006568 oxyanion strand; other site 199310006569 catalytic triad [active] 199310006570 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 199310006571 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 199310006572 catalytic residues [active] 199310006573 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 199310006574 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 199310006575 substrate binding site [chemical binding]; other site 199310006576 glutamase interaction surface [polypeptide binding]; other site 199310006577 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 199310006578 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 199310006579 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 199310006580 metal binding site [ion binding]; metal-binding site 199310006581 chain length determinant protein WzzB; Provisional; Region: PRK15471 199310006582 Chain length determinant protein; Region: Wzz; pfam02706 199310006583 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 199310006584 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 199310006585 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 199310006586 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 199310006587 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 199310006588 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 199310006589 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 199310006590 phosphomannomutase CpsG; Provisional; Region: PRK15414 199310006591 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 199310006592 active site 199310006593 substrate binding site [chemical binding]; other site 199310006594 metal binding site [ion binding]; metal-binding site 199310006595 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 199310006596 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 199310006597 Substrate binding site; other site 199310006598 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 199310006599 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 199310006600 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 199310006601 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 199310006602 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 199310006603 NAD binding site [chemical binding]; other site 199310006604 homodimer interface [polypeptide binding]; other site 199310006605 active site 199310006606 substrate binding site [chemical binding]; other site 199310006607 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 199310006608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 199310006609 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 199310006610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 199310006611 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 199310006612 active site 199310006613 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 199310006614 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 199310006615 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 199310006616 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 199310006617 active site 199310006618 tetramer interface; other site 199310006619 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 199310006620 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 199310006621 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 199310006622 putative ADP-binding pocket [chemical binding]; other site 199310006623 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 199310006624 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 199310006625 colanic acid exporter; Provisional; Region: PRK10459 199310006626 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 199310006627 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 199310006628 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 199310006629 phosphomannomutase CpsG; Provisional; Region: PRK15414 199310006630 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 199310006631 active site 199310006632 substrate binding site [chemical binding]; other site 199310006633 metal binding site [ion binding]; metal-binding site 199310006634 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 199310006635 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 199310006636 Substrate binding site; other site 199310006637 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 199310006638 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 199310006639 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 199310006640 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 199310006641 active site 199310006642 GDP-Mannose binding site [chemical binding]; other site 199310006643 dimer interface [polypeptide binding]; other site 199310006644 modified nudix motif 199310006645 metal binding site [ion binding]; metal-binding site 199310006646 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 199310006647 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 199310006648 NADP binding site [chemical binding]; other site 199310006649 active site 199310006650 putative substrate binding site [chemical binding]; other site 199310006651 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 199310006652 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 199310006653 NADP-binding site; other site 199310006654 homotetramer interface [polypeptide binding]; other site 199310006655 substrate binding site [chemical binding]; other site 199310006656 homodimer interface [polypeptide binding]; other site 199310006657 active site 199310006658 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 199310006659 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 199310006660 putative trimer interface [polypeptide binding]; other site 199310006661 putative active site [active] 199310006662 putative substrate binding site [chemical binding]; other site 199310006663 putative CoA binding site [chemical binding]; other site 199310006664 putative glycosyl transferase; Provisional; Region: PRK10063 199310006665 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 199310006666 metal-binding site 199310006667 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 199310006668 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 199310006669 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 199310006670 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 199310006671 putative acyl transferase; Provisional; Region: PRK10191 199310006672 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 199310006673 trimer interface [polypeptide binding]; other site 199310006674 active site 199310006675 substrate binding site [chemical binding]; other site 199310006676 CoA binding site [chemical binding]; other site 199310006677 putative glycosyl transferase; Provisional; Region: PRK10018 199310006678 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 199310006679 active site 199310006680 tyrosine kinase; Provisional; Region: PRK11519 199310006681 Chain length determinant protein; Region: Wzz; pfam02706 199310006682 Chain length determinant protein; Region: Wzz; cl15801 199310006683 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 199310006684 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 199310006685 Low molecular weight phosphatase family; Region: LMWPc; cl00105 199310006686 polysaccharide export protein Wza; Provisional; Region: PRK15078 199310006687 polysaccharide export protein Wza; Provisional; Region: PRK15078 199310006688 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 199310006689 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 199310006690 FOG: CBS domain [General function prediction only]; Region: COG0517 199310006691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 199310006692 Transporter associated domain; Region: CorC_HlyC; smart01091 199310006693 putative assembly protein; Provisional; Region: PRK10833 199310006694 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 199310006695 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 199310006696 trimer interface [polypeptide binding]; other site 199310006697 active site 199310006698 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 199310006699 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 199310006700 ATP-binding site [chemical binding]; other site 199310006701 Sugar specificity; other site 199310006702 Pyrimidine base specificity; other site 199310006703 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 199310006704 putative diguanylate cyclase; Provisional; Region: PRK09776 199310006705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310006706 putative active site [active] 199310006707 heme pocket [chemical binding]; other site 199310006708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310006709 putative active site [active] 199310006710 heme pocket [chemical binding]; other site 199310006711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310006712 putative active site [active] 199310006713 heme pocket [chemical binding]; other site 199310006714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310006715 metal binding site [ion binding]; metal-binding site 199310006716 active site 199310006717 I-site; other site 199310006718 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310006719 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 199310006720 AlkA N-terminal domain; Region: AlkA_N; smart01009 199310006721 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 199310006722 minor groove reading motif; other site 199310006723 helix-hairpin-helix signature motif; other site 199310006724 substrate binding pocket [chemical binding]; other site 199310006725 active site 199310006726 putative chaperone; Provisional; Region: PRK11678 199310006727 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 199310006728 nucleotide binding site [chemical binding]; other site 199310006729 putative NEF/HSP70 interaction site [polypeptide binding]; other site 199310006730 SBD interface [polypeptide binding]; other site 199310006731 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 199310006732 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 199310006733 substrate binding site [chemical binding]; other site 199310006734 activation loop (A-loop); other site 199310006735 Protein phosphatase 2C; Region: PP2C_2; pfam13672 199310006736 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 199310006737 metal ion-dependent adhesion site (MIDAS); other site 199310006738 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 199310006739 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310006740 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310006741 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 199310006742 Protein export membrane protein; Region: SecD_SecF; cl14618 199310006743 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 199310006744 putative transporter; Provisional; Region: PRK10504 199310006745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310006746 putative substrate translocation pore; other site 199310006747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 199310006748 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 199310006749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310006750 dimerization interface [polypeptide binding]; other site 199310006751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310006752 dimer interface [polypeptide binding]; other site 199310006753 phosphorylation site [posttranslational modification] 199310006754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310006755 ATP binding site [chemical binding]; other site 199310006756 Mg2+ binding site [ion binding]; other site 199310006757 G-X-G motif; other site 199310006758 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 199310006759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310006760 active site 199310006761 phosphorylation site [posttranslational modification] 199310006762 intermolecular recognition site; other site 199310006763 dimerization interface [polypeptide binding]; other site 199310006764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310006765 DNA binding site [nucleotide binding] 199310006766 Uncharacterized conserved protein [Function unknown]; Region: COG3422 199310006767 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 199310006768 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 199310006769 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 199310006770 PcfJ-like protein; Region: PcfJ; pfam14284 199310006771 putative protease; Provisional; Region: PRK15452 199310006772 Peptidase family U32; Region: Peptidase_U32; pfam01136 199310006773 lipid kinase; Reviewed; Region: PRK13054 199310006774 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 199310006775 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310006776 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 199310006777 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310006778 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 199310006779 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 199310006780 putative NAD(P) binding site [chemical binding]; other site 199310006781 catalytic Zn binding site [ion binding]; other site 199310006782 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 199310006783 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 199310006784 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 199310006785 active site 199310006786 P-loop; other site 199310006787 phosphorylation site [posttranslational modification] 199310006788 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310006789 active site 199310006790 phosphorylation site [posttranslational modification] 199310006791 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 199310006792 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 199310006793 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 199310006794 intersubunit interface [polypeptide binding]; other site 199310006795 active site 199310006796 zinc binding site [ion binding]; other site 199310006797 Na+ binding site [ion binding]; other site 199310006798 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310006799 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 199310006800 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 199310006801 putative active site; other site 199310006802 catalytic residue [active] 199310006803 nucleoside transporter; Region: 2A0110; TIGR00889 199310006804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310006805 putative substrate translocation pore; other site 199310006806 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 199310006807 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310006808 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 199310006809 substrate binding site [chemical binding]; other site 199310006810 ATP binding site [chemical binding]; other site 199310006811 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 199310006812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310006813 DNA-binding site [nucleotide binding]; DNA binding site 199310006814 UTRA domain; Region: UTRA; pfam07702 199310006815 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 199310006816 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 199310006817 active site 199310006818 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 199310006819 dimer interface [polypeptide binding]; other site 199310006820 substrate binding site [chemical binding]; other site 199310006821 ATP binding site [chemical binding]; other site 199310006822 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 199310006823 substrate binding site [chemical binding]; other site 199310006824 multimerization interface [polypeptide binding]; other site 199310006825 ATP binding site [chemical binding]; other site 199310006826 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 199310006827 putative metal binding site [ion binding]; other site 199310006828 putative homodimer interface [polypeptide binding]; other site 199310006829 putative homotetramer interface [polypeptide binding]; other site 199310006830 putative homodimer-homodimer interface [polypeptide binding]; other site 199310006831 putative allosteric switch controlling residues; other site 199310006832 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 199310006833 Predicted integral membrane protein [Function unknown]; Region: COG5455 199310006834 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 199310006835 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 199310006836 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 199310006837 PapC N-terminal domain; Region: PapC_N; pfam13954 199310006838 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310006839 PapC C-terminal domain; Region: PapC_C; pfam13953 199310006840 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 199310006841 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310006842 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310006843 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310006844 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310006845 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 199310006846 antiporter inner membrane protein; Provisional; Region: PRK11670 199310006847 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 199310006848 Walker A motif; other site 199310006849 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 199310006850 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 199310006851 active site 199310006852 HIGH motif; other site 199310006853 KMSKS motif; other site 199310006854 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 199310006855 tRNA binding surface [nucleotide binding]; other site 199310006856 anticodon binding site; other site 199310006857 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 199310006858 dimer interface [polypeptide binding]; other site 199310006859 putative tRNA-binding site [nucleotide binding]; other site 199310006860 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 199310006861 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 199310006862 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 199310006863 MoxR-like ATPases [General function prediction only]; Region: COG0714 199310006864 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 199310006865 Walker A motif; other site 199310006866 ATP binding site [chemical binding]; other site 199310006867 Walker B motif; other site 199310006868 arginine finger; other site 199310006869 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 199310006870 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 199310006871 metal ion-dependent adhesion site (MIDAS); other site 199310006872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 199310006873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 199310006874 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 199310006875 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 199310006876 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 199310006877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310006878 active site 199310006879 phosphorylation site [posttranslational modification] 199310006880 intermolecular recognition site; other site 199310006881 dimerization interface [polypeptide binding]; other site 199310006882 LytTr DNA-binding domain; Region: LytTR; pfam04397 199310006883 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 199310006884 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 199310006885 GAF domain; Region: GAF; pfam01590 199310006886 Histidine kinase; Region: His_kinase; pfam06580 199310006887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310006888 ATP binding site [chemical binding]; other site 199310006889 Mg2+ binding site [ion binding]; other site 199310006890 G-X-G motif; other site 199310006891 transcriptional regulator MirA; Provisional; Region: PRK15043 199310006892 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 199310006893 DNA binding residues [nucleotide binding] 199310006894 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 199310006895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310006896 dimer interface [polypeptide binding]; other site 199310006897 conserved gate region; other site 199310006898 putative PBP binding loops; other site 199310006899 ABC-ATPase subunit interface; other site 199310006900 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 199310006901 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 199310006902 Walker A/P-loop; other site 199310006903 ATP binding site [chemical binding]; other site 199310006904 Q-loop/lid; other site 199310006905 ABC transporter signature motif; other site 199310006906 Walker B; other site 199310006907 D-loop; other site 199310006908 H-loop/switch region; other site 199310006909 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 199310006910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310006911 dimer interface [polypeptide binding]; other site 199310006912 conserved gate region; other site 199310006913 ABC-ATPase subunit interface; other site 199310006914 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 199310006915 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 199310006916 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 199310006917 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 199310006918 D-lactate dehydrogenase; Provisional; Region: PRK11183 199310006919 FAD binding domain; Region: FAD_binding_4; pfam01565 199310006920 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 199310006921 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 199310006922 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 199310006923 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 199310006924 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 199310006925 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 199310006926 classical (c) SDRs; Region: SDR_c; cd05233 199310006927 active site 199310006928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 199310006929 NAD(P) binding site [chemical binding]; other site 199310006930 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 199310006931 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 199310006932 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 199310006933 FMN binding site [chemical binding]; other site 199310006934 active site 199310006935 catalytic residues [active] 199310006936 substrate binding site [chemical binding]; other site 199310006937 hypothetical protein; Provisional; Region: PRK01821 199310006938 hypothetical protein; Provisional; Region: PRK10711 199310006939 cytidine deaminase; Provisional; Region: PRK09027 199310006940 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 199310006941 active site 199310006942 catalytic motif [active] 199310006943 Zn binding site [ion binding]; other site 199310006944 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 199310006945 active site 199310006946 catalytic motif [active] 199310006947 Zn binding site [ion binding]; other site 199310006948 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 199310006949 putative active site [active] 199310006950 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 199310006951 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 199310006952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 199310006953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310006954 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 199310006955 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 199310006956 homodimer interface [polypeptide binding]; other site 199310006957 active site 199310006958 FMN binding site [chemical binding]; other site 199310006959 substrate binding site [chemical binding]; other site 199310006960 4Fe-4S binding domain; Region: Fer4; pfam00037 199310006961 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310006962 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310006963 TM-ABC transporter signature motif; other site 199310006964 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 199310006965 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 199310006966 Walker A/P-loop; other site 199310006967 ATP binding site [chemical binding]; other site 199310006968 Q-loop/lid; other site 199310006969 ABC transporter signature motif; other site 199310006970 Walker B; other site 199310006971 D-loop; other site 199310006972 H-loop/switch region; other site 199310006973 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310006974 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 199310006975 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 199310006976 ligand binding site [chemical binding]; other site 199310006977 calcium binding site [ion binding]; other site 199310006978 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 199310006979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310006980 DNA binding site [nucleotide binding] 199310006981 domain linker motif; other site 199310006982 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 199310006983 dimerization interface (closed form) [polypeptide binding]; other site 199310006984 ligand binding site [chemical binding]; other site 199310006985 Predicted membrane protein [Function unknown]; Region: COG2311 199310006986 hypothetical protein; Provisional; Region: PRK10835 199310006987 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 199310006988 homodecamer interface [polypeptide binding]; other site 199310006989 GTP cyclohydrolase I; Provisional; Region: PLN03044 199310006990 active site 199310006991 putative catalytic site residues [active] 199310006992 zinc binding site [ion binding]; other site 199310006993 GTP-CH-I/GFRP interaction surface; other site 199310006994 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 199310006995 S-formylglutathione hydrolase; Region: PLN02442 199310006996 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 199310006997 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310006998 N-terminal plug; other site 199310006999 ligand-binding site [chemical binding]; other site 199310007000 lysine transporter; Provisional; Region: PRK10836 199310007001 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 199310007002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310007003 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 199310007004 putative dimerization interface [polypeptide binding]; other site 199310007005 conserved hypothetical integral membrane protein; Region: TIGR00698 199310007006 endonuclease IV; Provisional; Region: PRK01060 199310007007 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 199310007008 AP (apurinic/apyrimidinic) site pocket; other site 199310007009 DNA interaction; other site 199310007010 Metal-binding active site; metal-binding site 199310007011 putative kinase; Provisional; Region: PRK09954 199310007012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 199310007013 putative DNA binding site [nucleotide binding]; other site 199310007014 putative Zn2+ binding site [ion binding]; other site 199310007015 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 199310007016 substrate binding site [chemical binding]; other site 199310007017 ATP binding site [chemical binding]; other site 199310007018 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 199310007019 active site 199310007020 tetramer interface [polypeptide binding]; other site 199310007021 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 199310007022 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 199310007023 ligand binding site [chemical binding]; other site 199310007024 flexible hinge region; other site 199310007025 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 199310007026 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 199310007027 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 199310007028 Nucleoside recognition; Region: Gate; pfam07670 199310007029 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 199310007030 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 199310007031 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310007032 substrate binding site [chemical binding]; other site 199310007033 ATP binding site [chemical binding]; other site 199310007034 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 199310007035 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 199310007036 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 199310007037 active site 199310007038 P-loop; other site 199310007039 phosphorylation site [posttranslational modification] 199310007040 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 199310007041 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 199310007042 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 199310007043 putative substrate binding site [chemical binding]; other site 199310007044 putative ATP binding site [chemical binding]; other site 199310007045 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 199310007046 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310007047 active site 199310007048 phosphorylation site [posttranslational modification] 199310007049 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 199310007050 dimerization domain swap beta strand [polypeptide binding]; other site 199310007051 regulatory protein interface [polypeptide binding]; other site 199310007052 active site 199310007053 regulatory phosphorylation site [posttranslational modification]; other site 199310007054 sugar efflux transporter B; Provisional; Region: PRK15011 199310007055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310007056 putative substrate translocation pore; other site 199310007057 elongation factor P; Provisional; Region: PRK04542 199310007058 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 199310007059 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 199310007060 RNA binding site [nucleotide binding]; other site 199310007061 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 199310007062 RNA binding site [nucleotide binding]; other site 199310007063 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 199310007064 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 199310007065 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 199310007066 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 199310007067 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 199310007068 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 199310007069 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 199310007070 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 199310007071 active site 199310007072 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 199310007073 NlpC/P60 family; Region: NLPC_P60; pfam00877 199310007074 phage resistance protein; Provisional; Region: PRK10551 199310007075 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 199310007076 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310007077 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 199310007078 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 199310007079 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 199310007080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310007081 dimer interface [polypeptide binding]; other site 199310007082 conserved gate region; other site 199310007083 putative PBP binding loops; other site 199310007084 ABC-ATPase subunit interface; other site 199310007085 microcin C ABC transporter permease; Provisional; Region: PRK15021 199310007086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310007087 dimer interface [polypeptide binding]; other site 199310007088 conserved gate region; other site 199310007089 ABC-ATPase subunit interface; other site 199310007090 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 199310007091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310007092 Walker A/P-loop; other site 199310007093 ATP binding site [chemical binding]; other site 199310007094 Q-loop/lid; other site 199310007095 ABC transporter signature motif; other site 199310007096 Walker B; other site 199310007097 D-loop; other site 199310007098 H-loop/switch region; other site 199310007099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 199310007100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310007101 Walker A/P-loop; other site 199310007102 ATP binding site [chemical binding]; other site 199310007103 Q-loop/lid; other site 199310007104 ABC transporter signature motif; other site 199310007105 Walker B; other site 199310007106 D-loop; other site 199310007107 H-loop/switch region; other site 199310007108 hypothetical protein; Provisional; Region: PRK11835 199310007109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310007110 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 199310007111 putative substrate translocation pore; other site 199310007112 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 199310007113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310007114 RNA binding surface [nucleotide binding]; other site 199310007115 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 199310007116 active site 199310007117 uracil binding [chemical binding]; other site 199310007118 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 199310007119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310007120 ATP binding site [chemical binding]; other site 199310007121 putative Mg++ binding site [ion binding]; other site 199310007122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310007123 nucleotide binding region [chemical binding]; other site 199310007124 ATP-binding site [chemical binding]; other site 199310007125 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 199310007126 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 199310007127 5S rRNA interface [nucleotide binding]; other site 199310007128 CTC domain interface [polypeptide binding]; other site 199310007129 L16 interface [polypeptide binding]; other site 199310007130 Nucleoid-associated protein [General function prediction only]; Region: COG3081 199310007131 nucleoid-associated protein NdpA; Validated; Region: PRK00378 199310007132 hypothetical protein; Provisional; Region: PRK13689 199310007133 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 199310007134 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 199310007135 Sulfatase; Region: Sulfatase; pfam00884 199310007136 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310007137 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310007138 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 199310007139 transcriptional regulator NarP; Provisional; Region: PRK10403 199310007140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310007141 active site 199310007142 phosphorylation site [posttranslational modification] 199310007143 intermolecular recognition site; other site 199310007144 dimerization interface [polypeptide binding]; other site 199310007145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310007146 DNA binding residues [nucleotide binding] 199310007147 dimerization interface [polypeptide binding]; other site 199310007148 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 199310007149 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 199310007150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 199310007151 binding surface 199310007152 TPR motif; other site 199310007153 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 199310007154 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 199310007155 catalytic residues [active] 199310007156 central insert; other site 199310007157 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 199310007158 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 199310007159 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 199310007160 heme exporter protein CcmC; Region: ccmC; TIGR01191 199310007161 heme exporter protein CcmB; Region: ccmB; TIGR01190 199310007162 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 199310007163 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 199310007164 Walker A/P-loop; other site 199310007165 ATP binding site [chemical binding]; other site 199310007166 Q-loop/lid; other site 199310007167 ABC transporter signature motif; other site 199310007168 Walker B; other site 199310007169 D-loop; other site 199310007170 H-loop/switch region; other site 199310007171 cytochrome c-type protein NapC; Provisional; Region: PRK10617 199310007172 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 199310007173 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 199310007174 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 199310007175 4Fe-4S binding domain; Region: Fer4_5; pfam12801 199310007176 4Fe-4S binding domain; Region: Fer4; cl02805 199310007177 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 199310007178 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 199310007179 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 199310007180 [4Fe-4S] binding site [ion binding]; other site 199310007181 molybdopterin cofactor binding site; other site 199310007182 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 199310007183 molybdopterin cofactor binding site; other site 199310007184 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 199310007185 ferredoxin-type protein; Provisional; Region: PRK10194 199310007186 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 199310007187 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 199310007188 secondary substrate binding site; other site 199310007189 primary substrate binding site; other site 199310007190 inhibition loop; other site 199310007191 dimerization interface [polypeptide binding]; other site 199310007192 malate:quinone oxidoreductase; Validated; Region: PRK05257 199310007193 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 199310007194 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 199310007195 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 199310007196 Walker A/P-loop; other site 199310007197 ATP binding site [chemical binding]; other site 199310007198 Q-loop/lid; other site 199310007199 ABC transporter signature motif; other site 199310007200 Walker B; other site 199310007201 D-loop; other site 199310007202 H-loop/switch region; other site 199310007203 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 199310007204 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 199310007205 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 199310007206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310007207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310007208 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 199310007209 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 199310007210 DNA binding site [nucleotide binding] 199310007211 active site 199310007212 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 199310007213 ApbE family; Region: ApbE; pfam02424 199310007214 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 199310007215 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 199310007216 trimer interface [polypeptide binding]; other site 199310007217 eyelet of channel; other site 199310007218 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 199310007219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310007220 ATP binding site [chemical binding]; other site 199310007221 G-X-G motif; other site 199310007222 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 199310007223 putative binding surface; other site 199310007224 active site 199310007225 transcriptional regulator RcsB; Provisional; Region: PRK10840 199310007226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310007227 active site 199310007228 phosphorylation site [posttranslational modification] 199310007229 intermolecular recognition site; other site 199310007230 dimerization interface [polypeptide binding]; other site 199310007231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310007232 DNA binding residues [nucleotide binding] 199310007233 dimerization interface [polypeptide binding]; other site 199310007234 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 199310007235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310007236 dimer interface [polypeptide binding]; other site 199310007237 phosphorylation site [posttranslational modification] 199310007238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310007239 ATP binding site [chemical binding]; other site 199310007240 Mg2+ binding site [ion binding]; other site 199310007241 G-X-G motif; other site 199310007242 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 199310007243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310007244 active site 199310007245 phosphorylation site [posttranslational modification] 199310007246 intermolecular recognition site; other site 199310007247 dimerization interface [polypeptide binding]; other site 199310007248 sensory histidine kinase AtoS; Provisional; Region: PRK11360 199310007249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310007250 putative active site [active] 199310007251 heme pocket [chemical binding]; other site 199310007252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310007253 dimer interface [polypeptide binding]; other site 199310007254 phosphorylation site [posttranslational modification] 199310007255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310007256 ATP binding site [chemical binding]; other site 199310007257 Mg2+ binding site [ion binding]; other site 199310007258 G-X-G motif; other site 199310007259 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 199310007260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310007261 active site 199310007262 phosphorylation site [posttranslational modification] 199310007263 intermolecular recognition site; other site 199310007264 dimerization interface [polypeptide binding]; other site 199310007265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310007266 Walker A motif; other site 199310007267 ATP binding site [chemical binding]; other site 199310007268 Walker B motif; other site 199310007269 arginine finger; other site 199310007270 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310007271 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 199310007272 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 199310007273 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 199310007274 putative acyltransferase; Provisional; Region: PRK05790 199310007275 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 199310007276 dimer interface [polypeptide binding]; other site 199310007277 active site 199310007278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 199310007279 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 199310007280 Predicted secreted protein [Function unknown]; Region: COG5445 199310007281 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 199310007282 Predicted secreted protein [Function unknown]; Region: COG5445 199310007283 Stage II sporulation protein; Region: SpoIID; pfam08486 199310007284 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 199310007285 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 199310007286 MG2 domain; Region: A2M_N; pfam01835 199310007287 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 199310007288 Alpha-2-macroglobulin family; Region: A2M; pfam00207 199310007289 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 199310007290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 199310007291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 199310007292 DNA gyrase subunit A; Validated; Region: PRK05560 199310007293 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 199310007294 CAP-like domain; other site 199310007295 active site 199310007296 primary dimer interface [polypeptide binding]; other site 199310007297 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 199310007298 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 199310007299 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 199310007300 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 199310007301 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 199310007302 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 199310007303 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 199310007304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310007305 S-adenosylmethionine binding site [chemical binding]; other site 199310007306 adhesin; Provisional; Region: PRK09752 199310007307 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 199310007308 Autotransporter beta-domain; Region: Autotransporter; pfam03797 199310007309 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 199310007310 ATP cone domain; Region: ATP-cone; pfam03477 199310007311 Class I ribonucleotide reductase; Region: RNR_I; cd01679 199310007312 active site 199310007313 dimer interface [polypeptide binding]; other site 199310007314 catalytic residues [active] 199310007315 effector binding site; other site 199310007316 R2 peptide binding site; other site 199310007317 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 199310007318 dimer interface [polypeptide binding]; other site 199310007319 putative radical transfer pathway; other site 199310007320 diiron center [ion binding]; other site 199310007321 tyrosyl radical; other site 199310007322 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 199310007323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 199310007324 catalytic loop [active] 199310007325 iron binding site [ion binding]; other site 199310007326 hypothetical protein; Provisional; Region: PRK09902 199310007327 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 199310007328 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 199310007329 active site 199310007330 catalytic site [active] 199310007331 metal binding site [ion binding]; metal-binding site 199310007332 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 199310007333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310007334 putative substrate translocation pore; other site 199310007335 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 199310007336 hydroxyglutarate oxidase; Provisional; Region: PRK11728 199310007337 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 199310007338 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 199310007339 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 199310007340 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 199310007341 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 199310007342 Cysteine-rich domain; Region: CCG; pfam02754 199310007343 Cysteine-rich domain; Region: CCG; pfam02754 199310007344 hypothetical protein; Provisional; Region: PRK09956 199310007345 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 199310007346 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 199310007347 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 199310007348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310007349 putative substrate translocation pore; other site 199310007350 L-rhamnonate dehydratase; Provisional; Region: PRK15440 199310007351 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 199310007352 putative active site pocket [active] 199310007353 putative metal binding site [ion binding]; other site 199310007354 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 199310007355 Transcriptional regulator [Transcription]; Region: IclR; COG1414 199310007356 Bacterial transcriptional regulator; Region: IclR; pfam01614 199310007357 hypothetical protein; Provisional; Region: PRK03673 199310007358 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 199310007359 putative MPT binding site; other site 199310007360 Competence-damaged protein; Region: CinA; cl00666 199310007361 YfaZ precursor; Region: YfaZ; pfam07437 199310007362 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 199310007363 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 199310007364 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 199310007365 catalytic core [active] 199310007366 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 199310007367 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 199310007368 inhibitor-cofactor binding pocket; inhibition site 199310007369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310007370 catalytic residue [active] 199310007371 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 199310007372 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 199310007373 Ligand binding site; other site 199310007374 Putative Catalytic site; other site 199310007375 DXD motif; other site 199310007376 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 199310007377 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 199310007378 substrate binding site [chemical binding]; other site 199310007379 cosubstrate binding site; other site 199310007380 catalytic site [active] 199310007381 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 199310007382 active site 199310007383 hexamer interface [polypeptide binding]; other site 199310007384 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 199310007385 NAD binding site [chemical binding]; other site 199310007386 substrate binding site [chemical binding]; other site 199310007387 active site 199310007388 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 199310007389 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 199310007390 putative active site [active] 199310007391 putative catalytic site [active] 199310007392 putative Zn binding site [ion binding]; other site 199310007393 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 199310007394 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 199310007395 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 199310007396 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 199310007397 signal transduction protein PmrD; Provisional; Region: PRK15450 199310007398 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 199310007399 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 199310007400 acyl-activating enzyme (AAE) consensus motif; other site 199310007401 putative AMP binding site [chemical binding]; other site 199310007402 putative active site [active] 199310007403 putative CoA binding site [chemical binding]; other site 199310007404 O-succinylbenzoate synthase; Provisional; Region: PRK05105 199310007405 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 199310007406 active site 199310007407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 199310007408 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 199310007409 substrate binding site [chemical binding]; other site 199310007410 oxyanion hole (OAH) forming residues; other site 199310007411 trimer interface [polypeptide binding]; other site 199310007412 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 199310007413 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 199310007414 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 199310007415 dimer interface [polypeptide binding]; other site 199310007416 tetramer interface [polypeptide binding]; other site 199310007417 PYR/PP interface [polypeptide binding]; other site 199310007418 TPP binding site [chemical binding]; other site 199310007419 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 199310007420 TPP-binding site; other site 199310007421 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 199310007422 isochorismate synthases; Region: isochor_syn; TIGR00543 199310007423 hypothetical protein; Provisional; Region: PRK10404 199310007424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310007425 Coenzyme A binding pocket [chemical binding]; other site 199310007426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 199310007427 von Willebrand factor; Region: vWF_A; pfam12450 199310007428 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 199310007429 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 199310007430 metal ion-dependent adhesion site (MIDAS); other site 199310007431 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 199310007432 M28 Zn-Peptidases; Region: M28_like_1; cd05640 199310007433 Peptidase family M28; Region: Peptidase_M28; pfam04389 199310007434 metal binding site [ion binding]; metal-binding site 199310007435 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 199310007436 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 199310007437 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 199310007438 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 199310007439 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 199310007440 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 199310007441 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 199310007442 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 199310007443 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 199310007444 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 199310007445 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 199310007446 4Fe-4S binding domain; Region: Fer4; pfam00037 199310007447 4Fe-4S binding domain; Region: Fer4; pfam00037 199310007448 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 199310007449 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 199310007450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 199310007451 catalytic loop [active] 199310007452 iron binding site [ion binding]; other site 199310007453 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 199310007454 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 199310007455 [4Fe-4S] binding site [ion binding]; other site 199310007456 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 199310007457 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 199310007458 SLBB domain; Region: SLBB; pfam10531 199310007459 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 199310007460 NADH dehydrogenase subunit E; Validated; Region: PRK07539 199310007461 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 199310007462 putative dimer interface [polypeptide binding]; other site 199310007463 [2Fe-2S] cluster binding site [ion binding]; other site 199310007464 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 199310007465 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 199310007466 NADH dehydrogenase subunit D; Validated; Region: PRK06075 199310007467 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 199310007468 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 199310007469 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 199310007470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310007471 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 199310007472 putative dimerization interface [polypeptide binding]; other site 199310007473 aminotransferase AlaT; Validated; Region: PRK09265 199310007474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310007475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310007476 homodimer interface [polypeptide binding]; other site 199310007477 catalytic residue [active] 199310007478 5'-nucleotidase; Provisional; Region: PRK03826 199310007479 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 199310007480 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 199310007481 TrkA-C domain; Region: TrkA_C; pfam02080 199310007482 TrkA-C domain; Region: TrkA_C; pfam02080 199310007483 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 199310007484 putative phosphatase; Provisional; Region: PRK11587 199310007485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310007486 motif II; other site 199310007487 hypothetical protein; Validated; Region: PRK05445 199310007488 hypothetical protein; Provisional; Region: PRK01816 199310007489 propionate/acetate kinase; Provisional; Region: PRK12379 199310007490 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 199310007491 phosphate acetyltransferase; Reviewed; Region: PRK05632 199310007492 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 199310007493 DRTGG domain; Region: DRTGG; pfam07085 199310007494 phosphate acetyltransferase; Region: pta; TIGR00651 199310007495 hypothetical protein; Provisional; Region: PRK11588 199310007496 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 199310007497 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 199310007498 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 199310007499 nudix motif; other site 199310007500 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 199310007501 active site 199310007502 metal binding site [ion binding]; metal-binding site 199310007503 homotetramer interface [polypeptide binding]; other site 199310007504 glutathione S-transferase; Provisional; Region: PRK15113 199310007505 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 199310007506 C-terminal domain interface [polypeptide binding]; other site 199310007507 GSH binding site (G-site) [chemical binding]; other site 199310007508 dimer interface [polypeptide binding]; other site 199310007509 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 199310007510 N-terminal domain interface [polypeptide binding]; other site 199310007511 putative dimer interface [polypeptide binding]; other site 199310007512 putative substrate binding pocket (H-site) [chemical binding]; other site 199310007513 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 199310007514 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 199310007515 C-terminal domain interface [polypeptide binding]; other site 199310007516 GSH binding site (G-site) [chemical binding]; other site 199310007517 dimer interface [polypeptide binding]; other site 199310007518 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 199310007519 N-terminal domain interface [polypeptide binding]; other site 199310007520 putative dimer interface [polypeptide binding]; other site 199310007521 active site 199310007522 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 199310007523 homooctamer interface [polypeptide binding]; other site 199310007524 active site 199310007525 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 199310007526 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 199310007527 putative NAD(P) binding site [chemical binding]; other site 199310007528 putative active site [active] 199310007529 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 199310007530 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 199310007531 Walker A/P-loop; other site 199310007532 ATP binding site [chemical binding]; other site 199310007533 Q-loop/lid; other site 199310007534 ABC transporter signature motif; other site 199310007535 Walker B; other site 199310007536 D-loop; other site 199310007537 H-loop/switch region; other site 199310007538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310007539 dimer interface [polypeptide binding]; other site 199310007540 conserved gate region; other site 199310007541 putative PBP binding loops; other site 199310007542 ABC-ATPase subunit interface; other site 199310007543 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 199310007544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310007545 dimer interface [polypeptide binding]; other site 199310007546 conserved gate region; other site 199310007547 putative PBP binding loops; other site 199310007548 ABC-ATPase subunit interface; other site 199310007549 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 199310007550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310007551 substrate binding pocket [chemical binding]; other site 199310007552 membrane-bound complex binding site; other site 199310007553 hinge residues; other site 199310007554 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 199310007555 Flavoprotein; Region: Flavoprotein; pfam02441 199310007556 amidophosphoribosyltransferase; Provisional; Region: PRK09246 199310007557 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 199310007558 active site 199310007559 tetramer interface [polypeptide binding]; other site 199310007560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310007561 active site 199310007562 colicin V production protein; Provisional; Region: PRK10845 199310007563 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 199310007564 cell division protein DedD; Provisional; Region: PRK11633 199310007565 Sporulation related domain; Region: SPOR; pfam05036 199310007566 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 199310007567 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 199310007568 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 199310007569 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 199310007570 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 199310007571 hypothetical protein; Provisional; Region: PRK10847 199310007572 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 199310007573 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 199310007574 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 199310007575 dimerization interface 3.5A [polypeptide binding]; other site 199310007576 active site 199310007577 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 199310007578 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 199310007579 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 199310007580 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 199310007581 ligand binding site [chemical binding]; other site 199310007582 NAD binding site [chemical binding]; other site 199310007583 catalytic site [active] 199310007584 homodimer interface [polypeptide binding]; other site 199310007585 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 199310007586 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 199310007587 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 199310007588 dimer interface [polypeptide binding]; other site 199310007589 active site 199310007590 Uncharacterized conserved protein [Function unknown]; Region: COG4121 199310007591 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 199310007592 YfcL protein; Region: YfcL; pfam08891 199310007593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 199310007594 hypothetical protein; Provisional; Region: PRK10621 199310007595 Predicted permeases [General function prediction only]; Region: COG0730 199310007596 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 199310007597 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 199310007598 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 199310007599 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 199310007600 Tetramer interface [polypeptide binding]; other site 199310007601 active site 199310007602 FMN-binding site [chemical binding]; other site 199310007603 HemK family putative methylases; Region: hemK_fam; TIGR00536 199310007604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310007605 S-adenosylmethionine binding site [chemical binding]; other site 199310007606 hypothetical protein; Provisional; Region: PRK04946 199310007607 Smr domain; Region: Smr; pfam01713 199310007608 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 199310007609 Fimbrial protein; Region: Fimbrial; cl01416 199310007610 Fimbrial protein; Region: Fimbrial; cl01416 199310007611 Fimbrial protein; Region: Fimbrial; cl01416 199310007612 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310007613 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310007614 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 199310007615 PapC N-terminal domain; Region: PapC_N; pfam13954 199310007616 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310007617 PapC C-terminal domain; Region: PapC_C; pfam13953 199310007618 Fimbrial protein; Region: Fimbrial; cl01416 199310007619 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 199310007620 catalytic core [active] 199310007621 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 199310007622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 199310007623 substrate binding site [chemical binding]; other site 199310007624 oxyanion hole (OAH) forming residues; other site 199310007625 trimer interface [polypeptide binding]; other site 199310007626 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 199310007627 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 199310007628 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 199310007629 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 199310007630 dimer interface [polypeptide binding]; other site 199310007631 active site 199310007632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 199310007633 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 199310007634 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 199310007635 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 199310007636 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 199310007637 Autotransporter beta-domain; Region: Autotransporter; pfam03797 199310007638 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 199310007639 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 199310007640 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 199310007641 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 199310007642 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 199310007643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310007644 DNA binding residues [nucleotide binding] 199310007645 dimerization interface [polypeptide binding]; other site 199310007646 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310007647 active site 199310007648 DNA binding site [nucleotide binding] 199310007649 Int/Topo IB signature motif; other site 199310007650 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310007651 active site 199310007652 DNA binding site [nucleotide binding] 199310007653 Int/Topo IB signature motif; other site 199310007654 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 199310007655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310007656 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 199310007657 dimerization interface [polypeptide binding]; other site 199310007658 substrate binding pocket [chemical binding]; other site 199310007659 permease DsdX; Provisional; Region: PRK09921 199310007660 gluconate transporter; Region: gntP; TIGR00791 199310007661 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 199310007662 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 199310007663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 199310007664 catalytic residue [active] 199310007665 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 199310007666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310007667 putative substrate translocation pore; other site 199310007668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310007669 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 199310007670 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310007671 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310007672 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 199310007673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310007674 active site 199310007675 phosphorylation site [posttranslational modification] 199310007676 intermolecular recognition site; other site 199310007677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310007678 DNA binding residues [nucleotide binding] 199310007679 dimerization interface [polypeptide binding]; other site 199310007680 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 199310007681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310007682 substrate binding pocket [chemical binding]; other site 199310007683 membrane-bound complex binding site; other site 199310007684 hinge residues; other site 199310007685 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310007686 substrate binding pocket [chemical binding]; other site 199310007687 membrane-bound complex binding site; other site 199310007688 hinge residues; other site 199310007689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310007690 dimer interface [polypeptide binding]; other site 199310007691 phosphorylation site [posttranslational modification] 199310007692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310007693 ATP binding site [chemical binding]; other site 199310007694 Mg2+ binding site [ion binding]; other site 199310007695 G-X-G motif; other site 199310007696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310007697 active site 199310007698 phosphorylation site [posttranslational modification] 199310007699 intermolecular recognition site; other site 199310007700 dimerization interface [polypeptide binding]; other site 199310007701 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 199310007702 putative binding surface; other site 199310007703 active site 199310007704 putative CoA-transferase; Provisional; Region: PRK11430 199310007705 CoA-transferase family III; Region: CoA_transf_3; pfam02515 199310007706 putative transporter YfdV; Provisional; Region: PRK09903 199310007707 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 199310007708 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 199310007709 PYR/PP interface [polypeptide binding]; other site 199310007710 dimer interface [polypeptide binding]; other site 199310007711 TPP binding site [chemical binding]; other site 199310007712 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 199310007713 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 199310007714 TPP-binding site; other site 199310007715 dimer interface [polypeptide binding]; other site 199310007716 formyl-coenzyme A transferase; Provisional; Region: PRK05398 199310007717 CoA-transferase family III; Region: CoA_transf_3; pfam02515 199310007718 hypothetical protein; Provisional; Region: PRK10316 199310007719 YfdX protein; Region: YfdX; pfam10938 199310007720 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 199310007721 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 199310007722 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 199310007723 putative acyl-acceptor binding pocket; other site 199310007724 aminotransferase; Validated; Region: PRK08175 199310007725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310007726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310007727 homodimer interface [polypeptide binding]; other site 199310007728 catalytic residue [active] 199310007729 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 199310007730 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 199310007731 GAF domain; Region: GAF; cl17456 199310007732 Histidine kinase; Region: His_kinase; pfam06580 199310007733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310007734 ATP binding site [chemical binding]; other site 199310007735 Mg2+ binding site [ion binding]; other site 199310007736 G-X-G motif; other site 199310007737 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 199310007738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310007739 active site 199310007740 phosphorylation site [posttranslational modification] 199310007741 intermolecular recognition site; other site 199310007742 dimerization interface [polypeptide binding]; other site 199310007743 LytTr DNA-binding domain; Region: LytTR; pfam04397 199310007744 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310007745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310007746 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 199310007747 dimerization domain swap beta strand [polypeptide binding]; other site 199310007748 regulatory protein interface [polypeptide binding]; other site 199310007749 active site 199310007750 regulatory phosphorylation site [posttranslational modification]; other site 199310007751 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 199310007752 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 199310007753 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 199310007754 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 199310007755 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310007756 active site 199310007757 phosphorylation site [posttranslational modification] 199310007758 exoaminopeptidase; Provisional; Region: PRK09961 199310007759 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 199310007760 oligomer interface [polypeptide binding]; other site 199310007761 active site 199310007762 metal binding site [ion binding]; metal-binding site 199310007763 aminopeptidase; Provisional; Region: PRK09795 199310007764 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 199310007765 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 199310007766 active site 199310007767 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 199310007768 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 199310007769 active site 199310007770 P-loop; other site 199310007771 phosphorylation site [posttranslational modification] 199310007772 glucokinase, proteobacterial type; Region: glk; TIGR00749 199310007773 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310007774 nucleotide binding site [chemical binding]; other site 199310007775 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 199310007776 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 199310007777 Cl- selectivity filter; other site 199310007778 Cl- binding residues [ion binding]; other site 199310007779 pore gating glutamate residue; other site 199310007780 dimer interface [polypeptide binding]; other site 199310007781 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 199310007782 manganese transport protein MntH; Reviewed; Region: PRK00701 199310007783 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 199310007784 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 199310007785 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 199310007786 Nucleoside recognition; Region: Gate; pfam07670 199310007787 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 199310007788 MASE1; Region: MASE1; pfam05231 199310007789 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310007790 diguanylate cyclase; Region: GGDEF; smart00267 199310007791 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310007792 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 199310007793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310007794 salt bridge; other site 199310007795 non-specific DNA binding site [nucleotide binding]; other site 199310007796 sequence-specific DNA binding site [nucleotide binding]; other site 199310007797 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 199310007798 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 199310007799 active site 199310007800 HIGH motif; other site 199310007801 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 199310007802 active site 199310007803 KMSKS motif; other site 199310007804 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 199310007805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310007806 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 199310007807 putative dimerization interface [polypeptide binding]; other site 199310007808 putative substrate binding pocket [chemical binding]; other site 199310007809 XapX domain; Region: XapX; TIGR03510 199310007810 nucleoside transporter; Region: 2A0110; TIGR00889 199310007811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310007812 putative substrate translocation pore; other site 199310007813 purine nucleoside phosphorylase; Provisional; Region: PRK08202 199310007814 hypothetical protein; Provisional; Region: PRK11528 199310007815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310007816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310007817 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 199310007818 putative dimerization interface [polypeptide binding]; other site 199310007819 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 199310007820 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 199310007821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 199310007822 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 199310007823 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 199310007824 nucleotide binding pocket [chemical binding]; other site 199310007825 K-X-D-G motif; other site 199310007826 catalytic site [active] 199310007827 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 199310007828 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 199310007829 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 199310007830 Dimer interface [polypeptide binding]; other site 199310007831 BRCT sequence motif; other site 199310007832 cell division protein ZipA; Provisional; Region: PRK03427 199310007833 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 199310007834 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 199310007835 FtsZ protein binding site [polypeptide binding]; other site 199310007836 putative sulfate transport protein CysZ; Validated; Region: PRK04949 199310007837 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 199310007838 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 199310007839 dimer interface [polypeptide binding]; other site 199310007840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310007841 catalytic residue [active] 199310007842 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 199310007843 dimerization domain swap beta strand [polypeptide binding]; other site 199310007844 regulatory protein interface [polypeptide binding]; other site 199310007845 active site 199310007846 regulatory phosphorylation site [posttranslational modification]; other site 199310007847 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 199310007848 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 199310007849 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 199310007850 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 199310007851 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 199310007852 HPr interaction site; other site 199310007853 glycerol kinase (GK) interaction site [polypeptide binding]; other site 199310007854 active site 199310007855 phosphorylation site [posttranslational modification] 199310007856 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 199310007857 dimer interface [polypeptide binding]; other site 199310007858 pyridoxamine kinase; Validated; Region: PRK05756 199310007859 pyridoxal binding site [chemical binding]; other site 199310007860 ATP binding site [chemical binding]; other site 199310007861 hypothetical protein; Provisional; Region: PRK10318 199310007862 cysteine synthase B; Region: cysM; TIGR01138 199310007863 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 199310007864 dimer interface [polypeptide binding]; other site 199310007865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310007866 catalytic residue [active] 199310007867 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 199310007868 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 199310007869 Walker A/P-loop; other site 199310007870 ATP binding site [chemical binding]; other site 199310007871 Q-loop/lid; other site 199310007872 ABC transporter signature motif; other site 199310007873 Walker B; other site 199310007874 D-loop; other site 199310007875 H-loop/switch region; other site 199310007876 TOBE-like domain; Region: TOBE_3; pfam12857 199310007877 sulfate transport protein; Provisional; Region: cysT; CHL00187 199310007878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310007879 dimer interface [polypeptide binding]; other site 199310007880 conserved gate region; other site 199310007881 putative PBP binding loops; other site 199310007882 ABC-ATPase subunit interface; other site 199310007883 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 199310007884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310007885 dimer interface [polypeptide binding]; other site 199310007886 conserved gate region; other site 199310007887 putative PBP binding loops; other site 199310007888 ABC-ATPase subunit interface; other site 199310007889 thiosulfate transporter subunit; Provisional; Region: PRK10852 199310007890 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 199310007891 short chain dehydrogenase; Provisional; Region: PRK08226 199310007892 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 199310007893 NAD binding site [chemical binding]; other site 199310007894 homotetramer interface [polypeptide binding]; other site 199310007895 homodimer interface [polypeptide binding]; other site 199310007896 active site 199310007897 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 199310007898 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 199310007899 putative active site [active] 199310007900 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 199310007901 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310007902 active site turn [active] 199310007903 phosphorylation site [posttranslational modification] 199310007904 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 199310007905 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 199310007906 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 199310007907 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 199310007908 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 199310007909 putative acetyltransferase; Provisional; Region: PRK03624 199310007910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310007911 Coenzyme A binding pocket [chemical binding]; other site 199310007912 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 199310007913 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 199310007914 active site 199310007915 metal binding site [ion binding]; metal-binding site 199310007916 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 199310007917 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 199310007918 transcriptional regulator EutR; Provisional; Region: PRK10130 199310007919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310007920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310007921 carboxysome structural protein EutK; Provisional; Region: PRK15466 199310007922 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 199310007923 Hexamer interface [polypeptide binding]; other site 199310007924 Hexagonal pore residue; other site 199310007925 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 199310007926 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 199310007927 putative hexamer interface [polypeptide binding]; other site 199310007928 putative hexagonal pore; other site 199310007929 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 199310007930 putative hexamer interface [polypeptide binding]; other site 199310007931 putative hexagonal pore; other site 199310007932 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 199310007933 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 199310007934 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 199310007935 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 199310007936 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 199310007937 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 199310007938 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 199310007939 active site 199310007940 metal binding site [ion binding]; metal-binding site 199310007941 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 199310007942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310007943 nucleotide binding site [chemical binding]; other site 199310007944 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 199310007945 putative catalytic cysteine [active] 199310007946 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 199310007947 Hexamer/Pentamer interface [polypeptide binding]; other site 199310007948 central pore; other site 199310007949 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 199310007950 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 199310007951 Hexamer interface [polypeptide binding]; other site 199310007952 Putative hexagonal pore residue; other site 199310007953 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 199310007954 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 199310007955 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 199310007956 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 199310007957 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 199310007958 G1 box; other site 199310007959 GTP/Mg2+ binding site [chemical binding]; other site 199310007960 G2 box; other site 199310007961 Switch I region; other site 199310007962 G3 box; other site 199310007963 Switch II region; other site 199310007964 G4 box; other site 199310007965 G5 box; other site 199310007966 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 199310007967 putative hexamer interface [polypeptide binding]; other site 199310007968 putative hexagonal pore; other site 199310007969 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 199310007970 Malic enzyme, N-terminal domain; Region: malic; pfam00390 199310007971 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 199310007972 putative NAD(P) binding site [chemical binding]; other site 199310007973 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 199310007974 transaldolase-like protein; Provisional; Region: PTZ00411 199310007975 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 199310007976 active site 199310007977 dimer interface [polypeptide binding]; other site 199310007978 catalytic residue [active] 199310007979 transketolase; Reviewed; Region: PRK12753 199310007980 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 199310007981 TPP-binding site [chemical binding]; other site 199310007982 dimer interface [polypeptide binding]; other site 199310007983 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 199310007984 PYR/PP interface [polypeptide binding]; other site 199310007985 dimer interface [polypeptide binding]; other site 199310007986 TPP binding site [chemical binding]; other site 199310007987 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 199310007988 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 199310007989 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 199310007990 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 199310007991 dimer interface [polypeptide binding]; other site 199310007992 ADP-ribose binding site [chemical binding]; other site 199310007993 active site 199310007994 nudix motif; other site 199310007995 metal binding site [ion binding]; metal-binding site 199310007996 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 199310007997 4Fe-4S binding domain; Region: Fer4; pfam00037 199310007998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 199310007999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310008000 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 199310008001 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 199310008002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310008003 dimerization interface [polypeptide binding]; other site 199310008004 Histidine kinase; Region: HisKA_3; pfam07730 199310008005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310008006 ATP binding site [chemical binding]; other site 199310008007 Mg2+ binding site [ion binding]; other site 199310008008 G-X-G motif; other site 199310008009 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 199310008010 Protein export membrane protein; Region: SecD_SecF; cl14618 199310008011 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 199310008012 ArsC family; Region: ArsC; pfam03960 199310008013 putative catalytic residues [active] 199310008014 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 199310008015 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 199310008016 metal binding site [ion binding]; metal-binding site 199310008017 dimer interface [polypeptide binding]; other site 199310008018 hypothetical protein; Provisional; Region: PRK13664 199310008019 putative hydrolase; Provisional; Region: PRK11460 199310008020 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 199310008021 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 199310008022 Helicase; Region: Helicase_RecD; pfam05127 199310008023 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 199310008024 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 199310008025 Predicted metalloprotease [General function prediction only]; Region: COG2321 199310008026 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 199310008027 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 199310008028 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 199310008029 ATP binding site [chemical binding]; other site 199310008030 active site 199310008031 substrate binding site [chemical binding]; other site 199310008032 lipoprotein; Provisional; Region: PRK11679 199310008033 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 199310008034 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 199310008035 dihydrodipicolinate synthase; Region: dapA; TIGR00674 199310008036 dimer interface [polypeptide binding]; other site 199310008037 active site 199310008038 catalytic residue [active] 199310008039 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 199310008040 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 199310008041 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 199310008042 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 199310008043 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 199310008044 catalytic triad [active] 199310008045 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 199310008046 Domain of unknown function DUF20; Region: UPF0118; pfam01594 199310008047 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 199310008048 Peptidase family M48; Region: Peptidase_M48; cl12018 199310008049 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 199310008050 ArsC family; Region: ArsC; pfam03960 199310008051 catalytic residues [active] 199310008052 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 199310008053 DNA replication initiation factor; Provisional; Region: PRK08084 199310008054 uracil transporter; Provisional; Region: PRK10720 199310008055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310008056 active site 199310008057 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 199310008058 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 199310008059 dimerization interface [polypeptide binding]; other site 199310008060 putative ATP binding site [chemical binding]; other site 199310008061 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 199310008062 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 199310008063 active site 199310008064 substrate binding site [chemical binding]; other site 199310008065 cosubstrate binding site; other site 199310008066 catalytic site [active] 199310008067 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 199310008068 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 199310008069 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 199310008070 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 199310008071 domain interface [polypeptide binding]; other site 199310008072 active site 199310008073 catalytic site [active] 199310008074 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 199310008075 putative active site [active] 199310008076 catalytic site [active] 199310008077 exopolyphosphatase; Provisional; Region: PRK10854 199310008078 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 199310008079 MASE1; Region: MASE1; pfam05231 199310008080 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 199310008081 diguanylate cyclase; Region: GGDEF; smart00267 199310008082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310008083 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 199310008084 GMP synthase; Reviewed; Region: guaA; PRK00074 199310008085 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 199310008086 AMP/PPi binding site [chemical binding]; other site 199310008087 candidate oxyanion hole; other site 199310008088 catalytic triad [active] 199310008089 potential glutamine specificity residues [chemical binding]; other site 199310008090 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 199310008091 ATP Binding subdomain [chemical binding]; other site 199310008092 Ligand Binding sites [chemical binding]; other site 199310008093 Dimerization subdomain; other site 199310008094 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 199310008095 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 199310008096 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 199310008097 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 199310008098 active site 199310008099 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 199310008100 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 199310008101 generic binding surface II; other site 199310008102 generic binding surface I; other site 199310008103 RatA-like protein; Provisional; Region: PRK15316 199310008104 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008105 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008106 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008107 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008108 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008109 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008110 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008111 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008112 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008113 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008114 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008115 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008116 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008117 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008118 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008119 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008120 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 199310008121 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 199310008122 intimin-like protein SinH; Provisional; Region: PRK15318 199310008123 intimin-like protein SinH; Provisional; Region: PRK15318 199310008124 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 199310008125 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 199310008126 GTP-binding protein Der; Reviewed; Region: PRK00093 199310008127 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 199310008128 G1 box; other site 199310008129 GTP/Mg2+ binding site [chemical binding]; other site 199310008130 Switch I region; other site 199310008131 G2 box; other site 199310008132 Switch II region; other site 199310008133 G3 box; other site 199310008134 G4 box; other site 199310008135 G5 box; other site 199310008136 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 199310008137 G1 box; other site 199310008138 GTP/Mg2+ binding site [chemical binding]; other site 199310008139 Switch I region; other site 199310008140 G2 box; other site 199310008141 G3 box; other site 199310008142 Switch II region; other site 199310008143 G4 box; other site 199310008144 G5 box; other site 199310008145 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 199310008146 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 199310008147 Trp docking motif [polypeptide binding]; other site 199310008148 active site 199310008149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 199310008150 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 199310008151 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 199310008152 dimer interface [polypeptide binding]; other site 199310008153 motif 1; other site 199310008154 active site 199310008155 motif 2; other site 199310008156 motif 3; other site 199310008157 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 199310008158 anticodon binding site; other site 199310008159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 199310008160 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 199310008161 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 199310008162 cytoskeletal protein RodZ; Provisional; Region: PRK10856 199310008163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310008164 non-specific DNA binding site [nucleotide binding]; other site 199310008165 salt bridge; other site 199310008166 sequence-specific DNA binding site [nucleotide binding]; other site 199310008167 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 199310008168 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 199310008169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310008170 FeS/SAM binding site; other site 199310008171 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 199310008172 active site 199310008173 multimer interface [polypeptide binding]; other site 199310008174 penicillin-binding protein 1C; Provisional; Region: PRK11240 199310008175 Transglycosylase; Region: Transgly; pfam00912 199310008176 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 199310008177 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 199310008178 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 199310008179 MG2 domain; Region: A2M_N; pfam01835 199310008180 Alpha-2-macroglobulin family; Region: A2M; pfam00207 199310008181 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 199310008182 surface patch; other site 199310008183 thioester region; other site 199310008184 specificity defining residues; other site 199310008185 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 199310008186 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 199310008187 active site residue [active] 199310008188 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 199310008189 active site residue [active] 199310008190 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 199310008191 aminopeptidase B; Provisional; Region: PRK05015 199310008192 Peptidase; Region: DUF3663; pfam12404 199310008193 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 199310008194 interface (dimer of trimers) [polypeptide binding]; other site 199310008195 Substrate-binding/catalytic site; other site 199310008196 Zn-binding sites [ion binding]; other site 199310008197 hypothetical protein; Provisional; Region: PRK10721 199310008198 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 199310008199 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 199310008200 catalytic loop [active] 199310008201 iron binding site [ion binding]; other site 199310008202 chaperone protein HscA; Provisional; Region: hscA; PRK05183 199310008203 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 199310008204 nucleotide binding site [chemical binding]; other site 199310008205 putative NEF/HSP70 interaction site [polypeptide binding]; other site 199310008206 SBD interface [polypeptide binding]; other site 199310008207 co-chaperone HscB; Provisional; Region: hscB; PRK05014 199310008208 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 199310008209 HSP70 interaction site [polypeptide binding]; other site 199310008210 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 199310008211 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 199310008212 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 199310008213 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 199310008214 trimerization site [polypeptide binding]; other site 199310008215 active site 199310008216 cysteine desulfurase; Provisional; Region: PRK14012 199310008217 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 199310008218 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 199310008219 catalytic residue [active] 199310008220 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 199310008221 Rrf2 family protein; Region: rrf2_super; TIGR00738 199310008222 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 199310008223 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 199310008224 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 199310008225 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 199310008226 active site 199310008227 dimerization interface [polypeptide binding]; other site 199310008228 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 199310008229 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 199310008230 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310008231 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 199310008232 PRD domain; Region: PRD; pfam00874 199310008233 PRD domain; Region: PRD; pfam00874 199310008234 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 199310008235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310008236 putative substrate translocation pore; other site 199310008237 Predicted membrane protein [Function unknown]; Region: COG2259 199310008238 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 199310008239 active site 199310008240 catalytic residues [active] 199310008241 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310008242 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 199310008243 putative NAD(P) binding site [chemical binding]; other site 199310008244 catalytic Zn binding site [ion binding]; other site 199310008245 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310008246 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310008247 TM-ABC transporter signature motif; other site 199310008248 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 199310008249 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 199310008250 Walker A/P-loop; other site 199310008251 ATP binding site [chemical binding]; other site 199310008252 Q-loop/lid; other site 199310008253 ABC transporter signature motif; other site 199310008254 Walker B; other site 199310008255 D-loop; other site 199310008256 H-loop/switch region; other site 199310008257 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310008258 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 199310008259 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 199310008260 ligand binding site [chemical binding]; other site 199310008261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310008262 TPR motif; other site 199310008263 binding surface 199310008264 TPR repeat; Region: TPR_11; pfam13414 199310008265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310008266 TPR motif; other site 199310008267 binding surface 199310008268 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 199310008269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 199310008270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310008271 nucleotide binding site [chemical binding]; other site 199310008272 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 199310008273 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 199310008274 dimer interface [polypeptide binding]; other site 199310008275 active site 199310008276 glycine-pyridoxal phosphate binding site [chemical binding]; other site 199310008277 folate binding site [chemical binding]; other site 199310008278 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 199310008279 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 199310008280 heme-binding site [chemical binding]; other site 199310008281 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 199310008282 FAD binding pocket [chemical binding]; other site 199310008283 FAD binding motif [chemical binding]; other site 199310008284 phosphate binding motif [ion binding]; other site 199310008285 beta-alpha-beta structure motif; other site 199310008286 NAD binding pocket [chemical binding]; other site 199310008287 Heme binding pocket [chemical binding]; other site 199310008288 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 199310008289 Nitrogen regulatory protein P-II; Region: P-II; smart00938 199310008290 response regulator GlrR; Provisional; Region: PRK15115 199310008291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310008292 active site 199310008293 phosphorylation site [posttranslational modification] 199310008294 intermolecular recognition site; other site 199310008295 dimerization interface [polypeptide binding]; other site 199310008296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310008297 Walker A motif; other site 199310008298 ATP binding site [chemical binding]; other site 199310008299 Walker B motif; other site 199310008300 arginine finger; other site 199310008301 hypothetical protein; Provisional; Region: PRK10722 199310008302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 199310008303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310008304 dimer interface [polypeptide binding]; other site 199310008305 phosphorylation site [posttranslational modification] 199310008306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310008307 ATP binding site [chemical binding]; other site 199310008308 Mg2+ binding site [ion binding]; other site 199310008309 G-X-G motif; other site 199310008310 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 199310008311 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 199310008312 dimerization interface [polypeptide binding]; other site 199310008313 ATP binding site [chemical binding]; other site 199310008314 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 199310008315 dimerization interface [polypeptide binding]; other site 199310008316 ATP binding site [chemical binding]; other site 199310008317 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 199310008318 putative active site [active] 199310008319 catalytic triad [active] 199310008320 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 199310008321 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310008322 substrate binding pocket [chemical binding]; other site 199310008323 membrane-bound complex binding site; other site 199310008324 hinge residues; other site 199310008325 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 199310008326 N-acetyl-D-glucosamine binding site [chemical binding]; other site 199310008327 catalytic residue [active] 199310008328 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 199310008329 nucleoside/Zn binding site; other site 199310008330 dimer interface [polypeptide binding]; other site 199310008331 catalytic motif [active] 199310008332 hypothetical protein; Provisional; Region: PRK11590 199310008333 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 199310008334 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 199310008335 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 199310008336 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 199310008337 putative active site [active] 199310008338 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 199310008339 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 199310008340 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 199310008341 active site 199310008342 hydrophilic channel; other site 199310008343 dimerization interface [polypeptide binding]; other site 199310008344 catalytic residues [active] 199310008345 active site lid [active] 199310008346 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 199310008347 Recombination protein O N terminal; Region: RecO_N; pfam11967 199310008348 Recombination protein O C terminal; Region: RecO_C; pfam02565 199310008349 GTPase Era; Reviewed; Region: era; PRK00089 199310008350 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 199310008351 G1 box; other site 199310008352 GTP/Mg2+ binding site [chemical binding]; other site 199310008353 Switch I region; other site 199310008354 G2 box; other site 199310008355 Switch II region; other site 199310008356 G3 box; other site 199310008357 G4 box; other site 199310008358 G5 box; other site 199310008359 KH domain; Region: KH_2; pfam07650 199310008360 ribonuclease III; Reviewed; Region: rnc; PRK00102 199310008361 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 199310008362 dimerization interface [polypeptide binding]; other site 199310008363 active site 199310008364 metal binding site [ion binding]; metal-binding site 199310008365 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 199310008366 dsRNA binding site [nucleotide binding]; other site 199310008367 signal peptidase I; Provisional; Region: PRK10861 199310008368 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 199310008369 Catalytic site [active] 199310008370 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 199310008371 GTP-binding protein LepA; Provisional; Region: PRK05433 199310008372 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 199310008373 G1 box; other site 199310008374 putative GEF interaction site [polypeptide binding]; other site 199310008375 GTP/Mg2+ binding site [chemical binding]; other site 199310008376 Switch I region; other site 199310008377 G2 box; other site 199310008378 G3 box; other site 199310008379 Switch II region; other site 199310008380 G4 box; other site 199310008381 G5 box; other site 199310008382 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 199310008383 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 199310008384 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 199310008385 SoxR reducing system protein RseC; Provisional; Region: PRK10862 199310008386 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 199310008387 anti-sigma E factor; Provisional; Region: rseB; PRK09455 199310008388 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 199310008389 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 199310008390 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 199310008391 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 199310008392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 199310008393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 199310008394 DNA binding residues [nucleotide binding] 199310008395 L-aspartate oxidase; Provisional; Region: PRK09077 199310008396 L-aspartate oxidase; Provisional; Region: PRK06175 199310008397 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 199310008398 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 199310008399 Methyltransferase domain; Region: Methyltransf_26; pfam13659 199310008400 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 199310008401 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 199310008402 ATP binding site [chemical binding]; other site 199310008403 Mg++ binding site [ion binding]; other site 199310008404 motif III; other site 199310008405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310008406 nucleotide binding region [chemical binding]; other site 199310008407 ATP-binding site [chemical binding]; other site 199310008408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310008409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310008410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 199310008411 dimerization interface [polypeptide binding]; other site 199310008412 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 199310008413 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 199310008414 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 199310008415 ligand binding site [chemical binding]; other site 199310008416 active site 199310008417 UGI interface [polypeptide binding]; other site 199310008418 catalytic site [active] 199310008419 putative methyltransferase; Provisional; Region: PRK10864 199310008420 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 199310008421 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 199310008422 thioredoxin 2; Provisional; Region: PRK10996 199310008423 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 199310008424 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 199310008425 catalytic residues [active] 199310008426 Uncharacterized conserved protein [Function unknown]; Region: COG3148 199310008427 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 199310008428 CoA binding domain; Region: CoA_binding_2; pfam13380 199310008429 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 199310008430 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 199310008431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 199310008432 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 199310008433 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 199310008434 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 199310008435 domain interface [polypeptide binding]; other site 199310008436 putative active site [active] 199310008437 catalytic site [active] 199310008438 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 199310008439 domain interface [polypeptide binding]; other site 199310008440 putative active site [active] 199310008441 catalytic site [active] 199310008442 lipoprotein; Provisional; Region: PRK10759 199310008443 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 199310008444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310008445 putative substrate translocation pore; other site 199310008446 protein disaggregation chaperone; Provisional; Region: PRK10865 199310008447 Clp amino terminal domain; Region: Clp_N; pfam02861 199310008448 Clp amino terminal domain; Region: Clp_N; pfam02861 199310008449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310008450 Walker A motif; other site 199310008451 ATP binding site [chemical binding]; other site 199310008452 Walker B motif; other site 199310008453 arginine finger; other site 199310008454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310008455 Walker A motif; other site 199310008456 ATP binding site [chemical binding]; other site 199310008457 Walker B motif; other site 199310008458 arginine finger; other site 199310008459 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 199310008460 hypothetical protein; Provisional; Region: PRK10723 199310008461 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 199310008462 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 199310008463 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310008464 RNA binding surface [nucleotide binding]; other site 199310008465 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 199310008466 active site 199310008467 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 199310008468 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 199310008469 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 199310008470 30S subunit binding site; other site 199310008471 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 199310008472 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 199310008473 Prephenate dehydratase; Region: PDT; pfam00800 199310008474 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 199310008475 putative L-Phe binding site [chemical binding]; other site 199310008476 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 199310008477 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 199310008478 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 199310008479 prephenate dehydrogenase; Validated; Region: PRK08507 199310008480 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 199310008481 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 199310008482 lipoprotein; Provisional; Region: PRK11443 199310008483 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 199310008484 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 199310008485 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 199310008486 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310008487 metal binding site [ion binding]; metal-binding site 199310008488 active site 199310008489 I-site; other site 199310008490 putative outer membrane lipoprotein; Provisional; Region: PRK09967 199310008491 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 199310008492 ligand binding site [chemical binding]; other site 199310008493 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 199310008494 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 199310008495 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 199310008496 RimM N-terminal domain; Region: RimM; pfam01782 199310008497 PRC-barrel domain; Region: PRC; pfam05239 199310008498 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 199310008499 signal recognition particle protein; Provisional; Region: PRK10867 199310008500 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 199310008501 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 199310008502 P loop; other site 199310008503 GTP binding site [chemical binding]; other site 199310008504 Signal peptide binding domain; Region: SRP_SPB; pfam02978 199310008505 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 199310008506 hypothetical protein; Provisional; Region: PRK11573 199310008507 Domain of unknown function DUF21; Region: DUF21; pfam01595 199310008508 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 199310008509 Transporter associated domain; Region: CorC_HlyC; smart01091 199310008510 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 199310008511 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 199310008512 dimer interface [polypeptide binding]; other site 199310008513 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 199310008514 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 199310008515 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 199310008516 recombination and repair protein; Provisional; Region: PRK10869 199310008517 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 199310008518 Walker A/P-loop; other site 199310008519 ATP binding site [chemical binding]; other site 199310008520 Q-loop/lid; other site 199310008521 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 199310008522 Q-loop/lid; other site 199310008523 ABC transporter signature motif; other site 199310008524 Walker B; other site 199310008525 D-loop; other site 199310008526 H-loop/switch region; other site 199310008527 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 199310008528 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 199310008529 hypothetical protein; Validated; Region: PRK01777 199310008530 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 199310008531 putative coenzyme Q binding site [chemical binding]; other site 199310008532 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 199310008533 SmpB-tmRNA interface; other site 199310008534 DinI-like family; Region: DinI; pfam06183 199310008535 multiple promoter invertase; Provisional; Region: mpi; PRK13413 199310008536 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 199310008537 catalytic residues [active] 199310008538 catalytic nucleophile [active] 199310008539 Presynaptic Site I dimer interface [polypeptide binding]; other site 199310008540 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 199310008541 Synaptic Flat tetramer interface [polypeptide binding]; other site 199310008542 Synaptic Site I dimer interface [polypeptide binding]; other site 199310008543 DNA binding site [nucleotide binding] 199310008544 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 199310008545 DNA-binding interface [nucleotide binding]; DNA binding site 199310008546 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 199310008547 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 199310008548 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310008549 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 199310008550 Phage-related protein, tail component [Function unknown]; Region: COG4733 199310008551 Putative phage tail protein; Region: Phage-tail_3; pfam13550 199310008552 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 199310008553 Fibronectin type III protein; Region: DUF3672; pfam12421 199310008554 Phage-related protein, tail component [Function unknown]; Region: COG4723 199310008555 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 199310008556 MPN+ (JAMM) motif; other site 199310008557 Zinc-binding site [ion binding]; other site 199310008558 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 199310008559 NlpC/P60 family; Region: NLPC_P60; cl17555 199310008560 Phage-related protein [Function unknown]; Region: gp18; COG4672 199310008561 Phage-related protein [Function unknown]; Region: COG4718 199310008562 Phage-related minor tail protein [Function unknown]; Region: COG5281 199310008563 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 199310008564 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 199310008565 Minor tail protein T; Region: Phage_tail_T; pfam06223 199310008566 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 199310008567 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 199310008568 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 199310008569 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 199310008570 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 199310008571 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 199310008572 DNA packaging protein FI; Region: Packaging_FI; pfam14000 199310008573 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 199310008574 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 199310008575 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 199310008576 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 199310008577 tandem repeat interface [polypeptide binding]; other site 199310008578 oligomer interface [polypeptide binding]; other site 199310008579 active site residues [active] 199310008580 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 199310008581 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 199310008582 gpW; Region: gpW; pfam02831 199310008583 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 199310008584 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 199310008585 GnsA/GnsB family; Region: GnsAB; pfam08178 199310008586 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310008587 DNA-binding site [nucleotide binding]; DNA binding site 199310008588 RNA-binding motif; other site 199310008589 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 199310008590 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 199310008591 catalytic residues [active] 199310008592 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 199310008593 Lysis protein S; Region: Lysis_S; pfam04971 199310008594 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310008595 DNA-binding site [nucleotide binding]; DNA binding site 199310008596 RNA-binding motif; other site 199310008597 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310008598 DNA-binding site [nucleotide binding]; DNA binding site 199310008599 RNA-binding motif; other site 199310008600 Antitermination protein; Region: Antiterm; pfam03589 199310008601 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 199310008602 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 199310008603 Antitermination protein; Region: Antiterm; pfam03589 199310008604 Protein of unknown function (DUF968); Region: DUF968; pfam06147 199310008605 KilA-N domain; Region: KilA-N; pfam04383 199310008606 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 199310008607 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 199310008608 PerC transcriptional activator; Region: PerC; pfam06069 199310008609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310008610 DNA-binding site [nucleotide binding]; DNA binding site 199310008611 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 199310008612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310008613 non-specific DNA binding site [nucleotide binding]; other site 199310008614 salt bridge; other site 199310008615 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 199310008616 sequence-specific DNA binding site [nucleotide binding]; other site 199310008617 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 199310008618 Catalytic site [active] 199310008619 Uncharacterized conserved protein [Function unknown]; Region: COG5532 199310008620 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 199310008621 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 199310008622 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 199310008623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310008624 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 199310008625 Int/Topo IB signature motif; other site 199310008626 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 199310008627 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 199310008628 substrate binding pocket [chemical binding]; other site 199310008629 active site 199310008630 iron coordination sites [ion binding]; other site 199310008631 Predicted dehydrogenase [General function prediction only]; Region: COG0579 199310008632 hydroxyglutarate oxidase; Provisional; Region: PRK11728 199310008633 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 199310008634 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 199310008635 tetramerization interface [polypeptide binding]; other site 199310008636 NAD(P) binding site [chemical binding]; other site 199310008637 catalytic residues [active] 199310008638 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 199310008639 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 199310008640 inhibitor-cofactor binding pocket; inhibition site 199310008641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310008642 catalytic residue [active] 199310008643 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 199310008644 TMPIT-like protein; Region: TMPIT; pfam07851 199310008645 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 199310008646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310008647 DNA-binding site [nucleotide binding]; DNA binding site 199310008648 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310008649 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 199310008650 bacterial OsmY and nodulation domain; Region: BON; smart00749 199310008651 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310008652 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 199310008653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 199310008654 dimerization interface [polypeptide binding]; other site 199310008655 putative DNA binding site [nucleotide binding]; other site 199310008656 putative Zn2+ binding site [ion binding]; other site 199310008657 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 199310008658 active site residue [active] 199310008659 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 199310008660 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 199310008661 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 199310008662 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 199310008663 hypothetical protein; Provisional; Region: PRK10556 199310008664 hypothetical protein; Provisional; Region: PRK10132 199310008665 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 199310008666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310008667 DNA-binding site [nucleotide binding]; DNA binding site 199310008668 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310008669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310008670 homodimer interface [polypeptide binding]; other site 199310008671 catalytic residue [active] 199310008672 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 199310008673 Uncharacterized conserved protein [Function unknown]; Region: COG2128 199310008674 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 199310008675 catalytic residues [active] 199310008676 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 199310008677 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 199310008678 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 199310008679 Class I ribonucleotide reductase; Region: RNR_I; cd01679 199310008680 active site 199310008681 dimer interface [polypeptide binding]; other site 199310008682 catalytic residues [active] 199310008683 effector binding site; other site 199310008684 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 199310008685 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 199310008686 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 199310008687 dimer interface [polypeptide binding]; other site 199310008688 putative radical transfer pathway; other site 199310008689 diiron center [ion binding]; other site 199310008690 tyrosyl radical; other site 199310008691 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 199310008692 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 199310008693 Walker A/P-loop; other site 199310008694 ATP binding site [chemical binding]; other site 199310008695 Q-loop/lid; other site 199310008696 ABC transporter signature motif; other site 199310008697 Walker B; other site 199310008698 D-loop; other site 199310008699 H-loop/switch region; other site 199310008700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 199310008701 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 199310008702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310008703 dimer interface [polypeptide binding]; other site 199310008704 conserved gate region; other site 199310008705 putative PBP binding loops; other site 199310008706 ABC-ATPase subunit interface; other site 199310008707 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 199310008708 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 199310008709 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 199310008710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310008711 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 199310008712 putative L-valine exporter; Provisional; Region: PRK10408 199310008713 transcriptional repressor MprA; Provisional; Region: PRK10870 199310008714 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 199310008715 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 199310008716 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310008717 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310008718 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 199310008719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310008720 putative substrate translocation pore; other site 199310008721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310008722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 199310008723 Zn2+ binding site [ion binding]; other site 199310008724 Mg2+ binding site [ion binding]; other site 199310008725 AAA domain; Region: AAA_33; pfam13671 199310008726 S-ribosylhomocysteinase; Provisional; Region: PRK02260 199310008727 glutamate--cysteine ligase; Provisional; Region: PRK02107 199310008728 Predicted membrane protein [Function unknown]; Region: COG1238 199310008729 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 199310008730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310008731 motif II; other site 199310008732 carbon storage regulator; Provisional; Region: PRK01712 199310008733 recombination regulator RecX; Reviewed; Region: recX; PRK00117 199310008734 recombinase A; Provisional; Region: recA; PRK09354 199310008735 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 199310008736 hexamer interface [polypeptide binding]; other site 199310008737 Walker A motif; other site 199310008738 ATP binding site [chemical binding]; other site 199310008739 Walker B motif; other site 199310008740 hypothetical protein; Validated; Region: PRK03661 199310008741 Transglycosylase SLT domain; Region: SLT_2; pfam13406 199310008742 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 199310008743 N-acetyl-D-glucosamine binding site [chemical binding]; other site 199310008744 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 199310008745 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 199310008746 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 199310008747 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 199310008748 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 199310008749 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 199310008750 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 199310008751 putative NAD(P) binding site [chemical binding]; other site 199310008752 active site 199310008753 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 199310008754 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 199310008755 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 199310008756 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310008757 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 199310008758 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 199310008759 putative active site [active] 199310008760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 199310008761 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 199310008762 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 199310008763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310008764 Walker A motif; other site 199310008765 ATP binding site [chemical binding]; other site 199310008766 Walker B motif; other site 199310008767 arginine finger; other site 199310008768 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 199310008769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310008770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310008771 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 199310008772 Acylphosphatase; Region: Acylphosphatase; pfam00708 199310008773 HypF finger; Region: zf-HYPF; pfam07503 199310008774 HypF finger; Region: zf-HYPF; pfam07503 199310008775 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 199310008776 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 199310008777 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 199310008778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310008779 non-specific DNA binding site [nucleotide binding]; other site 199310008780 salt bridge; other site 199310008781 sequence-specific DNA binding site [nucleotide binding]; other site 199310008782 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 199310008783 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 199310008784 nickel binding site [ion binding]; other site 199310008785 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 199310008786 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 199310008787 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 199310008788 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 199310008789 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 199310008790 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 199310008791 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 199310008792 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 199310008793 NADH dehydrogenase; Region: NADHdh; cl00469 199310008794 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 199310008795 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 199310008796 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 199310008797 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 199310008798 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 199310008799 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 199310008800 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 199310008801 hydrogenase assembly chaperone; Provisional; Region: PRK10409 199310008802 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 199310008803 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 199310008804 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 199310008805 dimerization interface [polypeptide binding]; other site 199310008806 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 199310008807 ATP binding site [chemical binding]; other site 199310008808 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 199310008809 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 199310008810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 199310008811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310008812 Walker A motif; other site 199310008813 ATP binding site [chemical binding]; other site 199310008814 Walker B motif; other site 199310008815 arginine finger; other site 199310008816 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 199310008817 molybdenum-pterin binding domain; Region: Mop; TIGR00638 199310008818 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 199310008819 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 199310008820 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 199310008821 MutS domain I; Region: MutS_I; pfam01624 199310008822 MutS domain II; Region: MutS_II; pfam05188 199310008823 MutS domain III; Region: MutS_III; pfam05192 199310008824 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 199310008825 Walker A/P-loop; other site 199310008826 ATP binding site [chemical binding]; other site 199310008827 Q-loop/lid; other site 199310008828 ABC transporter signature motif; other site 199310008829 Walker B; other site 199310008830 D-loop; other site 199310008831 H-loop/switch region; other site 199310008832 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 199310008833 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 199310008834 active site 199310008835 metal binding site [ion binding]; metal-binding site 199310008836 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310008837 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 199310008838 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310008839 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 199310008840 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 199310008841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 199310008842 putative aldolase; Validated; Region: PRK08130 199310008843 active site 199310008844 intersubunit interface [polypeptide binding]; other site 199310008845 Zn2+ binding site [ion binding]; other site 199310008846 hypothetical protein; Provisional; Region: PRK09989 199310008847 putative transporter; Provisional; Region: PRK09821 199310008848 GntP family permease; Region: GntP_permease; pfam02447 199310008849 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 199310008850 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 199310008851 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 199310008852 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 199310008853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 199310008854 DNA binding residues [nucleotide binding] 199310008855 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 199310008856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 199310008857 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 199310008858 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310008859 Peptidase family M23; Region: Peptidase_M23; pfam01551 199310008860 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 199310008861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310008862 S-adenosylmethionine binding site [chemical binding]; other site 199310008863 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 199310008864 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 199310008865 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 199310008866 Permutation of conserved domain; other site 199310008867 active site 199310008868 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 199310008869 homotrimer interaction site [polypeptide binding]; other site 199310008870 zinc binding site [ion binding]; other site 199310008871 CDP-binding sites; other site 199310008872 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 199310008873 substrate binding site; other site 199310008874 dimer interface; other site 199310008875 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 199310008876 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 199310008877 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 199310008878 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 199310008879 ligand-binding site [chemical binding]; other site 199310008880 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 199310008881 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 199310008882 CysD dimerization site [polypeptide binding]; other site 199310008883 G1 box; other site 199310008884 putative GEF interaction site [polypeptide binding]; other site 199310008885 GTP/Mg2+ binding site [chemical binding]; other site 199310008886 Switch I region; other site 199310008887 G2 box; other site 199310008888 G3 box; other site 199310008889 Switch II region; other site 199310008890 G4 box; other site 199310008891 G5 box; other site 199310008892 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 199310008893 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 199310008894 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 199310008895 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 199310008896 Active Sites [active] 199310008897 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 199310008898 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 199310008899 metal binding site [ion binding]; metal-binding site 199310008900 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 199310008901 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 199310008902 Active Sites [active] 199310008903 sulfite reductase subunit beta; Provisional; Region: PRK13504 199310008904 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 199310008905 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 199310008906 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 199310008907 Flavodoxin; Region: Flavodoxin_1; pfam00258 199310008908 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 199310008909 FAD binding pocket [chemical binding]; other site 199310008910 FAD binding motif [chemical binding]; other site 199310008911 catalytic residues [active] 199310008912 NAD binding pocket [chemical binding]; other site 199310008913 phosphate binding motif [ion binding]; other site 199310008914 beta-alpha-beta structure motif; other site 199310008915 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 199310008916 homohexamer interface [polypeptide binding]; other site 199310008917 putative substrate stabilizing pore; other site 199310008918 pterin binding site; other site 199310008919 FAD dependent oxidoreductase; Region: DAO; pfam01266 199310008920 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 199310008921 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 199310008922 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 199310008923 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 199310008924 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 199310008925 Ligand binding site [chemical binding]; other site 199310008926 Electron transfer flavoprotein domain; Region: ETF; pfam01012 199310008927 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 199310008928 benzoate transport; Region: 2A0115; TIGR00895 199310008929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310008930 putative substrate translocation pore; other site 199310008931 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 199310008932 FAD binding domain; Region: FAD_binding_4; pfam01565 199310008933 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 199310008934 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 199310008935 NADP binding site [chemical binding]; other site 199310008936 homodimer interface [polypeptide binding]; other site 199310008937 active site 199310008938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310008939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310008940 putative substrate translocation pore; other site 199310008941 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 199310008942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 199310008943 nucleotide binding site [chemical binding]; other site 199310008944 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 199310008945 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 199310008946 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 199310008947 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 199310008948 Repair protein; Region: Repair_PSII; pfam04536 199310008949 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 199310008950 Repair protein; Region: Repair_PSII; pfam04536 199310008951 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 199310008952 Repair protein; Region: Repair_PSII; pfam04536 199310008953 enolase; Provisional; Region: eno; PRK00077 199310008954 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 199310008955 dimer interface [polypeptide binding]; other site 199310008956 metal binding site [ion binding]; metal-binding site 199310008957 substrate binding pocket [chemical binding]; other site 199310008958 CTP synthetase; Validated; Region: pyrG; PRK05380 199310008959 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 199310008960 Catalytic site [active] 199310008961 active site 199310008962 UTP binding site [chemical binding]; other site 199310008963 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 199310008964 active site 199310008965 putative oxyanion hole; other site 199310008966 catalytic triad [active] 199310008967 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 199310008968 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 199310008969 homodimer interface [polypeptide binding]; other site 199310008970 metal binding site [ion binding]; metal-binding site 199310008971 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 199310008972 homodimer interface [polypeptide binding]; other site 199310008973 active site 199310008974 putative chemical substrate binding site [chemical binding]; other site 199310008975 metal binding site [ion binding]; metal-binding site 199310008976 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 199310008977 HD domain; Region: HD_4; pfam13328 199310008978 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 199310008979 synthetase active site [active] 199310008980 NTP binding site [chemical binding]; other site 199310008981 metal binding site [ion binding]; metal-binding site 199310008982 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 199310008983 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 199310008984 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 199310008985 TRAM domain; Region: TRAM; pfam01938 199310008986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310008987 S-adenosylmethionine binding site [chemical binding]; other site 199310008988 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 199310008989 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 199310008990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310008991 dimerization interface [polypeptide binding]; other site 199310008992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310008993 dimer interface [polypeptide binding]; other site 199310008994 phosphorylation site [posttranslational modification] 199310008995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310008996 ATP binding site [chemical binding]; other site 199310008997 Mg2+ binding site [ion binding]; other site 199310008998 G-X-G motif; other site 199310008999 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 199310009000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310009001 active site 199310009002 phosphorylation site [posttranslational modification] 199310009003 intermolecular recognition site; other site 199310009004 dimerization interface [polypeptide binding]; other site 199310009005 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 199310009006 putative binding surface; other site 199310009007 active site 199310009008 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 199310009009 tetramer interface [polypeptide binding]; other site 199310009010 active site 199310009011 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 199310009012 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 199310009013 active site 199310009014 tetramer interface [polypeptide binding]; other site 199310009015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009016 D-galactonate transporter; Region: 2A0114; TIGR00893 199310009017 putative substrate translocation pore; other site 199310009018 flavodoxin; Provisional; Region: PRK08105 199310009019 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 199310009020 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 199310009021 probable active site [active] 199310009022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 199310009023 SecY interacting protein Syd; Provisional; Region: PRK04968 199310009024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 199310009025 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 199310009026 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 199310009027 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 199310009028 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 199310009029 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 199310009030 serine transporter; Region: stp; TIGR00814 199310009031 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 199310009032 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 199310009033 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 199310009034 flap endonuclease-like protein; Provisional; Region: PRK09482 199310009035 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 199310009036 active site 199310009037 metal binding site 1 [ion binding]; metal-binding site 199310009038 putative 5' ssDNA interaction site; other site 199310009039 metal binding site 3; metal-binding site 199310009040 metal binding site 2 [ion binding]; metal-binding site 199310009041 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 199310009042 putative DNA binding site [nucleotide binding]; other site 199310009043 putative metal binding site [ion binding]; other site 199310009044 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 199310009045 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 199310009046 dimer interface [polypeptide binding]; other site 199310009047 active site 199310009048 metal binding site [ion binding]; metal-binding site 199310009049 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 199310009050 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 199310009051 intersubunit interface [polypeptide binding]; other site 199310009052 active site 199310009053 Zn2+ binding site [ion binding]; other site 199310009054 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 199310009055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009056 putative substrate translocation pore; other site 199310009057 L-fucose isomerase; Provisional; Region: fucI; PRK10991 199310009058 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 199310009059 hexamer (dimer of trimers) interface [polypeptide binding]; other site 199310009060 trimer interface [polypeptide binding]; other site 199310009061 substrate binding site [chemical binding]; other site 199310009062 Mn binding site [ion binding]; other site 199310009063 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 199310009064 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 199310009065 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 199310009066 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310009067 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 199310009068 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 199310009069 hypothetical protein; Provisional; Region: PRK10873 199310009070 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 199310009071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310009072 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 199310009073 dimerization interface [polypeptide binding]; other site 199310009074 substrate binding pocket [chemical binding]; other site 199310009075 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 199310009076 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 199310009077 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 199310009078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 199310009079 catalytic residue [active] 199310009080 CsdA-binding activator; Provisional; Region: PRK15019 199310009081 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 199310009082 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 199310009083 putative ATP binding site [chemical binding]; other site 199310009084 putative substrate interface [chemical binding]; other site 199310009085 murein transglycosylase A; Provisional; Region: mltA; PRK11162 199310009086 MltA specific insert domain; Region: MltA; pfam03562 199310009087 3D domain; Region: 3D; pfam06725 199310009088 Protein of unknown function (DUF770); Region: DUF770; pfam05591 199310009089 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 199310009090 Protein of unknown function (DUF877); Region: DUF877; pfam05943 199310009091 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 199310009092 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 199310009093 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 199310009094 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 199310009095 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 199310009096 ligand binding site [chemical binding]; other site 199310009097 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 199310009098 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 199310009099 Clp amino terminal domain; Region: Clp_N; pfam02861 199310009100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310009101 Walker A motif; other site 199310009102 ATP binding site [chemical binding]; other site 199310009103 Walker B motif; other site 199310009104 arginine finger; other site 199310009105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310009106 Walker A motif; other site 199310009107 ATP binding site [chemical binding]; other site 199310009108 Walker B motif; other site 199310009109 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 199310009110 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 199310009111 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 199310009112 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 199310009113 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 199310009114 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 199310009115 PAAR motif; Region: PAAR_motif; pfam05488 199310009116 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 199310009117 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 199310009118 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 199310009119 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 199310009120 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 199310009121 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 199310009122 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 199310009123 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 199310009124 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 199310009125 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 199310009126 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 199310009127 ImpA domain protein; Region: DUF3702; pfam12486 199310009128 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 199310009129 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 199310009130 putative ligand binding site [chemical binding]; other site 199310009131 putative NAD binding site [chemical binding]; other site 199310009132 catalytic site [active] 199310009133 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 199310009134 putative active site [active] 199310009135 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 199310009136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310009137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310009138 homodimer interface [polypeptide binding]; other site 199310009139 catalytic residue [active] 199310009140 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 199310009141 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 199310009142 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310009143 active site turn [active] 199310009144 phosphorylation site [posttranslational modification] 199310009145 CAT RNA binding domain; Region: CAT_RBD; pfam03123 199310009146 PRD domain; Region: PRD; pfam00874 199310009147 PRD domain; Region: PRD; pfam00874 199310009148 AMIN domain; Region: AMIN; pfam11741 199310009149 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 199310009150 active site 199310009151 metal binding site [ion binding]; metal-binding site 199310009152 N-acetylglutamate synthase; Validated; Region: PRK05279 199310009153 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 199310009154 putative feedback inhibition sensing region; other site 199310009155 putative nucleotide binding site [chemical binding]; other site 199310009156 putative substrate binding site [chemical binding]; other site 199310009157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310009158 Coenzyme A binding pocket [chemical binding]; other site 199310009159 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 199310009160 AAA domain; Region: AAA_30; pfam13604 199310009161 Family description; Region: UvrD_C_2; pfam13538 199310009162 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 199310009163 protease3; Provisional; Region: PRK15101 199310009164 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 199310009165 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 199310009166 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 199310009167 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 199310009168 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 199310009169 hypothetical protein; Provisional; Region: PRK10332 199310009170 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 199310009171 hypothetical protein; Provisional; Region: PRK11521 199310009172 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 199310009173 hypothetical protein; Provisional; Region: PRK10557 199310009174 hypothetical protein; Provisional; Region: PRK10506 199310009175 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 199310009176 thymidylate synthase; Reviewed; Region: thyA; PRK01827 199310009177 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 199310009178 dimerization interface [polypeptide binding]; other site 199310009179 active site 199310009180 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 199310009181 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 199310009182 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 199310009183 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 199310009184 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 199310009185 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 199310009186 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 199310009187 putative active site [active] 199310009188 Ap4A binding site [chemical binding]; other site 199310009189 nudix motif; other site 199310009190 putative metal binding site [ion binding]; other site 199310009191 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 199310009192 putative DNA-binding cleft [nucleotide binding]; other site 199310009193 putative DNA clevage site; other site 199310009194 molecular lever; other site 199310009195 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 199310009196 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 199310009197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310009198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310009199 active site 199310009200 catalytic tetrad [active] 199310009201 lysophospholipid transporter LplT; Provisional; Region: PRK11195 199310009202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009203 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 199310009204 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 199310009205 putative acyl-acceptor binding pocket; other site 199310009206 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 199310009207 acyl-activating enzyme (AAE) consensus motif; other site 199310009208 putative AMP binding site [chemical binding]; other site 199310009209 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310009210 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 199310009211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310009212 DNA binding site [nucleotide binding] 199310009213 domain linker motif; other site 199310009214 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 199310009215 dimerization interface (closed form) [polypeptide binding]; other site 199310009216 ligand binding site [chemical binding]; other site 199310009217 diaminopimelate decarboxylase; Provisional; Region: PRK11165 199310009218 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 199310009219 active site 199310009220 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 199310009221 substrate binding site [chemical binding]; other site 199310009222 catalytic residues [active] 199310009223 dimer interface [polypeptide binding]; other site 199310009224 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 199310009225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310009226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310009227 dimerization interface [polypeptide binding]; other site 199310009228 putative racemase; Provisional; Region: PRK10200 199310009229 aspartate racemase; Region: asp_race; TIGR00035 199310009230 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 199310009231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009232 putative substrate translocation pore; other site 199310009233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009234 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 199310009235 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 199310009236 NADP binding site [chemical binding]; other site 199310009237 homodimer interface [polypeptide binding]; other site 199310009238 active site 199310009239 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 199310009240 putative acyltransferase; Provisional; Region: PRK05790 199310009241 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 199310009242 dimer interface [polypeptide binding]; other site 199310009243 active site 199310009244 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 199310009245 serine transporter; Region: stp; TIGR00814 199310009246 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 199310009247 Peptidase family M23; Region: Peptidase_M23; pfam01551 199310009248 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 199310009249 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 199310009250 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 199310009251 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 199310009252 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 199310009253 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 199310009254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 199310009255 catalytic loop [active] 199310009256 iron binding site [ion binding]; other site 199310009257 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 199310009258 GAF domain; Region: GAF; cl17456 199310009259 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 199310009260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310009261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310009262 Walker A motif; other site 199310009263 ATP binding site [chemical binding]; other site 199310009264 Walker B motif; other site 199310009265 arginine finger; other site 199310009266 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310009267 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 199310009268 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 199310009269 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 199310009270 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 199310009271 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 199310009272 catalytic residue [active] 199310009273 peptidase; Reviewed; Region: PRK13004 199310009274 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 199310009275 putative metal binding site [ion binding]; other site 199310009276 putative dimer interface [polypeptide binding]; other site 199310009277 D-hydantoinase; Region: D-hydantoinase; TIGR02033 199310009278 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 199310009279 tetramer interface [polypeptide binding]; other site 199310009280 active site 199310009281 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 199310009282 carbamate kinase; Reviewed; Region: PRK12686 199310009283 putative substrate binding site [chemical binding]; other site 199310009284 homodimer interface [polypeptide binding]; other site 199310009285 nucleotide binding site [chemical binding]; other site 199310009286 nucleotide binding site [chemical binding]; other site 199310009287 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 199310009288 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 199310009289 XdhC Rossmann domain; Region: XdhC_C; pfam13478 199310009290 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 199310009291 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 199310009292 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 199310009293 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 199310009294 Ligand binding site; other site 199310009295 metal-binding site 199310009296 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 199310009297 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 199310009298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310009299 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 199310009300 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 199310009301 active site 199310009302 putative substrate binding pocket [chemical binding]; other site 199310009303 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 199310009304 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 199310009305 putative hypoxanthine oxidase; Provisional; Region: PRK09800 199310009306 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 199310009307 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 199310009308 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 199310009309 uracil-xanthine permease; Region: ncs2; TIGR00801 199310009310 guanine deaminase; Provisional; Region: PRK09228 199310009311 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 199310009312 active site 199310009313 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 199310009314 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 199310009315 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 199310009316 4Fe-4S binding domain; Region: Fer4; pfam00037 199310009317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 199310009318 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310009319 xanthine permease; Region: pbuX; TIGR03173 199310009320 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 199310009321 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 199310009322 active site 199310009323 metal binding site [ion binding]; metal-binding site 199310009324 nudix motif; other site 199310009325 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310009326 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 199310009327 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 199310009328 dimer interface [polypeptide binding]; other site 199310009329 putative anticodon binding site; other site 199310009330 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 199310009331 motif 1; other site 199310009332 active site 199310009333 motif 2; other site 199310009334 motif 3; other site 199310009335 peptide chain release factor 2; Validated; Region: prfB; PRK00578 199310009336 This domain is found in peptide chain release factors; Region: PCRF; smart00937 199310009337 RF-1 domain; Region: RF-1; pfam00472 199310009338 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 199310009339 DHH family; Region: DHH; pfam01368 199310009340 DHHA1 domain; Region: DHHA1; pfam02272 199310009341 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 199310009342 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 199310009343 dimerization domain [polypeptide binding]; other site 199310009344 dimer interface [polypeptide binding]; other site 199310009345 catalytic residues [active] 199310009346 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 199310009347 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 199310009348 active site 199310009349 Int/Topo IB signature motif; other site 199310009350 flavodoxin FldB; Provisional; Region: PRK12359 199310009351 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 199310009352 hypothetical protein; Provisional; Region: PRK10878 199310009353 putative global regulator; Reviewed; Region: PRK09559 199310009354 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 199310009355 hemolysin; Provisional; Region: PRK15087 199310009356 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 199310009357 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 199310009358 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 199310009359 beta-galactosidase; Region: BGL; TIGR03356 199310009360 glycine dehydrogenase; Provisional; Region: PRK05367 199310009361 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 199310009362 tetramer interface [polypeptide binding]; other site 199310009363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310009364 catalytic residue [active] 199310009365 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 199310009366 tetramer interface [polypeptide binding]; other site 199310009367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310009368 catalytic residue [active] 199310009369 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 199310009370 lipoyl attachment site [posttranslational modification]; other site 199310009371 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 199310009372 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 199310009373 oxidoreductase; Provisional; Region: PRK08013 199310009374 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 199310009375 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 199310009376 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 199310009377 proline aminopeptidase P II; Provisional; Region: PRK10879 199310009378 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 199310009379 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 199310009380 active site 199310009381 hypothetical protein; Reviewed; Region: PRK01736 199310009382 Z-ring-associated protein; Provisional; Region: PRK10972 199310009383 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 199310009384 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 199310009385 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 199310009386 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 199310009387 ligand binding site [chemical binding]; other site 199310009388 NAD binding site [chemical binding]; other site 199310009389 tetramer interface [polypeptide binding]; other site 199310009390 catalytic site [active] 199310009391 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 199310009392 L-serine binding site [chemical binding]; other site 199310009393 ACT domain interface; other site 199310009394 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 199310009395 tetramer (dimer of dimers) interface [polypeptide binding]; other site 199310009396 active site 199310009397 dimer interface [polypeptide binding]; other site 199310009398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310009399 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 199310009400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310009401 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 199310009402 putative dimerization interface [polypeptide binding]; other site 199310009403 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 199310009404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310009405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310009406 Uncharacterized conserved protein [Function unknown]; Region: COG2968 199310009407 oxidative stress defense protein; Provisional; Region: PRK11087 199310009408 arginine exporter protein; Provisional; Region: PRK09304 199310009409 mechanosensitive channel MscS; Provisional; Region: PRK10334 199310009410 Mechanosensitive ion channel; Region: MS_channel; pfam00924 199310009411 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 199310009412 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 199310009413 active site 199310009414 intersubunit interface [polypeptide binding]; other site 199310009415 zinc binding site [ion binding]; other site 199310009416 Na+ binding site [ion binding]; other site 199310009417 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 199310009418 Phosphoglycerate kinase; Region: PGK; pfam00162 199310009419 substrate binding site [chemical binding]; other site 199310009420 hinge regions; other site 199310009421 ADP binding site [chemical binding]; other site 199310009422 catalytic site [active] 199310009423 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 199310009424 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 199310009425 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 199310009426 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 199310009427 trimer interface [polypeptide binding]; other site 199310009428 putative Zn binding site [ion binding]; other site 199310009429 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 199310009430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310009431 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 199310009432 Q-loop/lid; other site 199310009433 ABC transporter signature motif; other site 199310009434 Walker B; other site 199310009435 D-loop; other site 199310009436 H-loop/switch region; other site 199310009437 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 199310009438 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 199310009439 Walker A/P-loop; other site 199310009440 ATP binding site [chemical binding]; other site 199310009441 Q-loop/lid; other site 199310009442 ABC transporter signature motif; other site 199310009443 Walker B; other site 199310009444 D-loop; other site 199310009445 H-loop/switch region; other site 199310009446 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 199310009447 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 199310009448 active site 199310009449 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 199310009450 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 199310009451 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 199310009452 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 199310009453 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310009454 putative NAD(P) binding site [chemical binding]; other site 199310009455 catalytic Zn binding site [ion binding]; other site 199310009456 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 199310009457 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 199310009458 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 199310009459 active site 199310009460 P-loop; other site 199310009461 phosphorylation site [posttranslational modification] 199310009462 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310009463 active site 199310009464 phosphorylation site [posttranslational modification] 199310009465 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 199310009466 SPFH domain / Band 7 family; Region: Band_7; pfam01145 199310009467 transketolase; Reviewed; Region: PRK12753 199310009468 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 199310009469 TPP-binding site [chemical binding]; other site 199310009470 dimer interface [polypeptide binding]; other site 199310009471 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 199310009472 PYR/PP interface [polypeptide binding]; other site 199310009473 dimer interface [polypeptide binding]; other site 199310009474 TPP binding site [chemical binding]; other site 199310009475 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 199310009476 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 199310009477 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 199310009478 agmatinase; Region: agmatinase; TIGR01230 199310009479 oligomer interface [polypeptide binding]; other site 199310009480 putative active site [active] 199310009481 Mn binding site [ion binding]; other site 199310009482 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 199310009483 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 199310009484 dimer interface [polypeptide binding]; other site 199310009485 active site 199310009486 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 199310009487 catalytic residues [active] 199310009488 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 199310009489 Virulence promoting factor; Region: YqgB; pfam11036 199310009490 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 199310009491 S-adenosylmethionine synthetase; Validated; Region: PRK05250 199310009492 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 199310009493 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 199310009494 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 199310009495 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 199310009496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009497 putative substrate translocation pore; other site 199310009498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009499 hypothetical protein; Provisional; Region: PRK04860 199310009500 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 199310009501 DNA-specific endonuclease I; Provisional; Region: PRK15137 199310009502 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 199310009503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 199310009504 RNA methyltransferase, RsmE family; Region: TIGR00046 199310009505 glutathione synthetase; Provisional; Region: PRK05246 199310009506 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 199310009507 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 199310009508 hypothetical protein; Validated; Region: PRK00228 199310009509 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 199310009510 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 199310009511 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 199310009512 Walker A motif; other site 199310009513 ATP binding site [chemical binding]; other site 199310009514 Walker B motif; other site 199310009515 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 199310009516 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 199310009517 catalytic residue [active] 199310009518 YGGT family; Region: YGGT; pfam02325 199310009519 YGGT family; Region: YGGT; pfam02325 199310009520 hypothetical protein; Validated; Region: PRK05090 199310009521 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 199310009522 active site 199310009523 dimerization interface [polypeptide binding]; other site 199310009524 HemN family oxidoreductase; Provisional; Region: PRK05660 199310009525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310009526 FeS/SAM binding site; other site 199310009527 HemN C-terminal domain; Region: HemN_C; pfam06969 199310009528 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 199310009529 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 199310009530 homodimer interface [polypeptide binding]; other site 199310009531 active site 199310009532 hypothetical protein; Provisional; Region: PRK10626 199310009533 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 199310009534 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 199310009535 hypothetical protein; Provisional; Region: PRK11702 199310009536 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 199310009537 adenine DNA glycosylase; Provisional; Region: PRK10880 199310009538 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 199310009539 minor groove reading motif; other site 199310009540 helix-hairpin-helix signature motif; other site 199310009541 substrate binding pocket [chemical binding]; other site 199310009542 active site 199310009543 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 199310009544 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 199310009545 DNA binding and oxoG recognition site [nucleotide binding] 199310009546 oxidative damage protection protein; Provisional; Region: PRK05408 199310009547 murein transglycosylase C; Provisional; Region: mltC; PRK11671 199310009548 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 199310009549 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 199310009550 N-acetyl-D-glucosamine binding site [chemical binding]; other site 199310009551 catalytic residue [active] 199310009552 nucleoside transporter; Region: 2A0110; TIGR00889 199310009553 ornithine decarboxylase; Provisional; Region: PRK13578 199310009554 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 199310009555 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 199310009556 homodimer interface [polypeptide binding]; other site 199310009557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310009558 catalytic residue [active] 199310009559 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 199310009560 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 199310009561 integrase; Provisional; Region: PRK09692 199310009562 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310009563 active site 199310009564 Int/Topo IB signature motif; other site 199310009565 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 199310009566 Sulfatase; Region: Sulfatase; cl17466 199310009567 Transposase; Region: HTH_Tnp_1; pfam01527 199310009568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310009569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009570 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 199310009571 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310009572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009574 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 199310009575 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310009576 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310009577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 199310009578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310009579 dimer interface [polypeptide binding]; other site 199310009580 phosphorylation site [posttranslational modification] 199310009581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310009582 ATP binding site [chemical binding]; other site 199310009583 Mg2+ binding site [ion binding]; other site 199310009584 G-X-G motif; other site 199310009585 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 199310009586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310009587 active site 199310009588 phosphorylation site [posttranslational modification] 199310009589 intermolecular recognition site; other site 199310009590 dimerization interface [polypeptide binding]; other site 199310009591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310009592 DNA binding site [nucleotide binding] 199310009593 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 199310009594 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 199310009595 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 199310009596 Moco binding site; other site 199310009597 metal coordination site [ion binding]; other site 199310009598 RTX toxin acyltransferase family; Region: HlyC; pfam02794 199310009599 RTX N-terminal domain; Region: RTX; pfam02382 199310009600 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 199310009601 RTX C-terminal domain; Region: RTX_C; pfam08339 199310009602 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 199310009603 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 199310009604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 199310009605 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 199310009606 Walker A/P-loop; other site 199310009607 ATP binding site [chemical binding]; other site 199310009608 Q-loop/lid; other site 199310009609 ABC transporter signature motif; other site 199310009610 Walker B; other site 199310009611 D-loop; other site 199310009612 H-loop/switch region; other site 199310009613 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 199310009614 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310009615 putative transposase OrfB; Reviewed; Region: PHA02517 199310009616 Integrase core domain; Region: rve; pfam00665 199310009617 Integrase core domain; Region: rve_3; pfam13683 199310009618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310009619 Transposase; Region: HTH_Tnp_1; pfam01527 199310009620 Transposase; Region: HTH_Tnp_1; pfam01527 199310009621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310009622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009623 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 199310009624 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310009625 MarR family; Region: MarR_2; cl17246 199310009626 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 199310009627 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 199310009628 putative membrane interaction site; other site 199310009629 receptor/carbohydrate binding site; other site 199310009630 PapG chaperone-binding domain; Region: PapG_C; pfam03628 199310009631 Fimbrial protein; Region: Fimbrial; pfam00419 199310009632 Fimbrial protein; Region: Fimbrial; pfam00419 199310009633 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310009634 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310009635 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310009636 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 199310009637 PapC N-terminal domain; Region: PapC_N; pfam13954 199310009638 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310009639 PapC C-terminal domain; Region: PapC_C; pfam13953 199310009640 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310009641 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310009642 FaeA-like protein; Region: FaeA; pfam04703 199310009643 Integrase core domain; Region: rve; pfam00665 199310009644 Integrase core domain; Region: rve_3; pfam13683 199310009645 HTH-like domain; Region: HTH_21; pfam13276 199310009646 Transposase; Region: HTH_Tnp_1; cl17663 199310009647 Transposase; Region: DDE_Tnp_ISL3; pfam01610 199310009648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 199310009649 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310009650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 199310009651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310009652 Protein of unknown function, DUF417; Region: DUF417; pfam04224 199310009653 Integrase core domain; Region: rve; pfam00665 199310009654 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 199310009655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310009656 Walker A motif; other site 199310009657 ATP binding site [chemical binding]; other site 199310009658 Walker B motif; other site 199310009659 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 199310009660 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 199310009661 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310009662 N-terminal plug; other site 199310009663 ligand-binding site [chemical binding]; other site 199310009664 IS2 transposase TnpB; Reviewed; Region: PRK09409 199310009665 HTH-like domain; Region: HTH_21; pfam13276 199310009666 Integrase core domain; Region: rve; pfam00665 199310009667 Integrase core domain; Region: rve_3; pfam13683 199310009668 Transposase; Region: HTH_Tnp_1; cl17663 199310009669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310009670 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310009671 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310009672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009673 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 199310009674 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310009675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009676 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 199310009677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310009678 Transposase; Region: HTH_Tnp_1; pfam01527 199310009679 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 199310009680 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 199310009681 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 199310009682 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310009683 Autotransporter beta-domain; Region: Autotransporter; pfam03797 199310009684 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 199310009685 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310009686 N-terminal plug; other site 199310009687 ligand-binding site [chemical binding]; other site 199310009688 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 199310009689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310009690 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 199310009691 IucA / IucC family; Region: IucA_IucC; pfam04183 199310009692 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 199310009693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 199310009694 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 199310009695 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 199310009696 IucA / IucC family; Region: IucA_IucC; pfam04183 199310009697 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 199310009698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 199310009700 putative substrate translocation pore; other site 199310009701 Domain of unknown function (DUF303); Region: DUF303; pfam03629 199310009702 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 199310009703 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310009704 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 199310009705 Kelch motif; Region: Kelch_1; pfam01344 199310009706 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 199310009707 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 199310009708 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310009709 putative sialic acid transporter; Provisional; Region: PRK03893 199310009710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310009711 putative substrate translocation pore; other site 199310009712 N-acetylmannosamine kinase; Provisional; Region: PRK05082 199310009713 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310009714 nucleotide binding site [chemical binding]; other site 199310009715 N-acetylneuraminate lyase; Provisional; Region: PRK04147 199310009716 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 199310009717 inhibitor site; inhibition site 199310009718 active site 199310009719 dimer interface [polypeptide binding]; other site 199310009720 catalytic residue [active] 199310009721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310009722 Transposase; Region: HTH_Tnp_1; pfam01527 199310009723 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 199310009724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009725 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310009726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009727 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 199310009728 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310009729 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 199310009730 homodimer interface [polypeptide binding]; other site 199310009731 putative GKAP docking site [polypeptide binding]; other site 199310009732 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310009733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009734 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 199310009735 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310009736 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310009737 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 199310009738 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 199310009739 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310009740 Haemolysin expression modulating protein; Region: HHA; pfam05321 199310009741 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 199310009742 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 199310009743 Predicted GTPase [General function prediction only]; Region: COG3596 199310009744 YfjP GTPase; Region: YfjP; cd11383 199310009745 G1 box; other site 199310009746 GTP/Mg2+ binding site [chemical binding]; other site 199310009747 Switch I region; other site 199310009748 G2 box; other site 199310009749 Switch II region; other site 199310009750 G3 box; other site 199310009751 G4 box; other site 199310009752 G5 box; other site 199310009753 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 199310009754 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 199310009755 hypothetical protein; Provisional; Region: PRK09945 199310009756 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 199310009757 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 199310009758 Autotransporter beta-domain; Region: Autotransporter; smart00869 199310009759 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 199310009760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009761 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310009762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009763 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 199310009764 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310009765 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310009766 Transposase; Region: HTH_Tnp_1; pfam01527 199310009767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310009768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009769 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 199310009770 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 199310009771 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 199310009772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 199310009773 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 199310009774 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310009775 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 199310009776 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310009777 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 199310009778 Domain of unknown function (DUF932); Region: DUF932; pfam06067 199310009779 Antirestriction protein; Region: Antirestrict; pfam03230 199310009780 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 199310009781 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 199310009782 MPN+ (JAMM) motif; other site 199310009783 Zinc-binding site [ion binding]; other site 199310009784 Protein of unknown function (DUF987); Region: DUF987; pfam06174 199310009785 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 199310009786 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 199310009787 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 199310009788 Methyltransferase domain; Region: Methyltransf_27; pfam13708 199310009789 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 199310009790 KpsF/GutQ family protein; Region: kpsF; TIGR00393 199310009791 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 199310009792 putative active site [active] 199310009793 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 199310009794 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 199310009795 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 199310009796 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 199310009797 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 199310009798 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 199310009799 Ligand binding site; other site 199310009800 oligomer interface; other site 199310009801 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 199310009802 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 199310009803 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 199310009804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310009805 TPR motif; other site 199310009806 TPR repeat; Region: TPR_11; pfam13414 199310009807 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 199310009808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310009809 TPR motif; other site 199310009810 binding surface 199310009811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310009812 binding surface 199310009813 TPR motif; other site 199310009814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 199310009815 binding surface 199310009816 TPR motif; other site 199310009817 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 199310009818 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 199310009819 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 199310009820 putative ADP-binding pocket [chemical binding]; other site 199310009821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 199310009822 Tetratricopeptide repeat; Region: TPR_16; pfam13432 199310009823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310009824 TPR motif; other site 199310009825 binding surface 199310009826 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 199310009827 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 199310009828 active site 199310009829 nucleotide binding site [chemical binding]; other site 199310009830 HIGH motif; other site 199310009831 KMSKS motif; other site 199310009832 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 199310009833 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 199310009834 Walker A/P-loop; other site 199310009835 ATP binding site [chemical binding]; other site 199310009836 Q-loop/lid; other site 199310009837 ABC transporter signature motif; other site 199310009838 Walker B; other site 199310009839 D-loop; other site 199310009840 H-loop/switch region; other site 199310009841 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 199310009842 ABC-2 type transporter; Region: ABC2_membrane; cl17235 199310009843 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 199310009844 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 199310009845 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 199310009846 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 199310009847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 199310009848 glycolate transporter; Provisional; Region: PRK09695 199310009849 L-lactate permease; Region: Lactate_perm; cl00701 199310009850 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 199310009851 active site 199310009852 hypothetical protein; Provisional; Region: PRK09732 199310009853 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 199310009854 FAD binding domain; Region: FAD_binding_4; pfam01565 199310009855 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 199310009856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310009857 DNA-binding site [nucleotide binding]; DNA binding site 199310009858 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310009859 acyl-CoA synthetase; Validated; Region: PRK09192 199310009860 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 199310009861 acyl-activating enzyme (AAE) consensus motif; other site 199310009862 active site 199310009863 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 199310009864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 199310009865 NAD(P) binding site [chemical binding]; other site 199310009866 active site 199310009867 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 199310009868 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 199310009869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 199310009870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 199310009871 catalytic residue [active] 199310009872 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 199310009873 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 199310009874 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 199310009875 Predicted permeases [General function prediction only]; Region: COG0795 199310009876 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 199310009877 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 199310009878 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 199310009879 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 199310009880 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 199310009881 active site 199310009882 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 199310009883 TMP-binding site; other site 199310009884 ATP-binding site [chemical binding]; other site 199310009885 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 199310009886 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 199310009887 TMP-binding site; other site 199310009888 ATP-binding site [chemical binding]; other site 199310009889 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 199310009890 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 199310009891 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 199310009892 CHAP domain; Region: CHAP; pfam05257 199310009893 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 199310009894 putative S-transferase; Provisional; Region: PRK11752 199310009895 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 199310009896 C-terminal domain interface [polypeptide binding]; other site 199310009897 GSH binding site (G-site) [chemical binding]; other site 199310009898 dimer interface [polypeptide binding]; other site 199310009899 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 199310009900 dimer interface [polypeptide binding]; other site 199310009901 N-terminal domain interface [polypeptide binding]; other site 199310009902 active site 199310009903 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 199310009904 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 199310009905 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 199310009906 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 199310009907 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 199310009908 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 199310009909 putative substrate-binding site; other site 199310009910 nickel binding site [ion binding]; other site 199310009911 hydrogenase 2 large subunit; Provisional; Region: PRK10467 199310009912 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 199310009913 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 199310009914 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 199310009915 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 199310009916 4Fe-4S binding domain; Region: Fer4_6; pfam12837 199310009917 hydrogenase 2 small subunit; Provisional; Region: PRK10468 199310009918 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 199310009919 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 199310009920 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 199310009921 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 199310009922 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310009923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310009924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310009925 active site 199310009926 catalytic tetrad [active] 199310009927 hypothetical protein; Provisional; Region: PRK05208 199310009928 oxidoreductase; Provisional; Region: PRK07985 199310009929 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 199310009930 NAD binding site [chemical binding]; other site 199310009931 metal binding site [ion binding]; metal-binding site 199310009932 active site 199310009933 biopolymer transport protein ExbD; Provisional; Region: PRK11267 199310009934 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 199310009935 biopolymer transport protein ExbB; Provisional; Region: PRK10414 199310009936 cystathionine beta-lyase; Provisional; Region: PRK08114 199310009937 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 199310009938 homodimer interface [polypeptide binding]; other site 199310009939 substrate-cofactor binding pocket; other site 199310009940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310009941 catalytic residue [active] 199310009942 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 199310009943 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 199310009944 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 199310009945 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 199310009946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310009947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310009948 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 199310009949 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 199310009950 dimer interface [polypeptide binding]; other site 199310009951 active site 199310009952 metal binding site [ion binding]; metal-binding site 199310009953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 199310009954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 199310009955 active site 199310009956 catalytic tetrad [active] 199310009957 putative outer membrane lipoprotein; Provisional; Region: PRK09973 199310009958 hypothetical protein; Provisional; Region: PRK01254 199310009959 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 199310009960 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 199310009961 Transcriptional regulators [Transcription]; Region: FadR; COG2186 199310009962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310009963 DNA-binding site [nucleotide binding]; DNA binding site 199310009964 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310009965 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 199310009966 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 199310009967 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 199310009968 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310009969 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 199310009970 putative NAD(P) binding site [chemical binding]; other site 199310009971 catalytic Zn binding site [ion binding]; other site 199310009972 structural Zn binding site [ion binding]; other site 199310009973 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 199310009974 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 199310009975 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 199310009976 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 199310009977 DctM-like transporters; Region: DctM; pfam06808 199310009978 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 199310009979 FtsI repressor; Provisional; Region: PRK10883 199310009980 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 199310009981 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 199310009982 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 199310009983 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 199310009984 putative acyl-acceptor binding pocket; other site 199310009985 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 199310009986 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 199310009987 CAP-like domain; other site 199310009988 active site 199310009989 primary dimer interface [polypeptide binding]; other site 199310009990 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 199310009991 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 199310009992 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 199310009993 peptide binding site [polypeptide binding]; other site 199310009994 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 199310009995 TIGR00156 family protein; Region: TIGR00156 199310009996 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 199310009997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310009998 active site 199310009999 phosphorylation site [posttranslational modification] 199310010000 intermolecular recognition site; other site 199310010001 dimerization interface [polypeptide binding]; other site 199310010002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310010003 DNA binding site [nucleotide binding] 199310010004 sensor protein QseC; Provisional; Region: PRK10337 199310010005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310010006 dimer interface [polypeptide binding]; other site 199310010007 phosphorylation site [posttranslational modification] 199310010008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310010009 ATP binding site [chemical binding]; other site 199310010010 Mg2+ binding site [ion binding]; other site 199310010011 G-X-G motif; other site 199310010012 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 199310010013 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 199310010014 Uncharacterized conserved protein [Function unknown]; Region: COG1359 199310010015 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 199310010016 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 199310010017 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 199310010018 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 199310010019 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 199310010020 siderophore binding site; other site 199310010021 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 199310010022 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310010023 ABC-ATPase subunit interface; other site 199310010024 dimer interface [polypeptide binding]; other site 199310010025 putative PBP binding regions; other site 199310010026 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 199310010027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310010028 dimer interface [polypeptide binding]; other site 199310010029 putative PBP binding regions; other site 199310010030 ABC-ATPase subunit interface; other site 199310010031 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 199310010032 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310010033 Walker A/P-loop; other site 199310010034 ATP binding site [chemical binding]; other site 199310010035 Q-loop/lid; other site 199310010036 ABC transporter signature motif; other site 199310010037 Walker B; other site 199310010038 D-loop; other site 199310010039 H-loop/switch region; other site 199310010040 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 199310010041 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310010042 N-terminal plug; other site 199310010043 ligand-binding site [chemical binding]; other site 199310010044 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 199310010045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310010046 ATP binding site [chemical binding]; other site 199310010047 Mg2+ binding site [ion binding]; other site 199310010048 G-X-G motif; other site 199310010049 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 199310010050 anchoring element; other site 199310010051 dimer interface [polypeptide binding]; other site 199310010052 ATP binding site [chemical binding]; other site 199310010053 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 199310010054 active site 199310010055 metal binding site [ion binding]; metal-binding site 199310010056 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 199310010057 esterase YqiA; Provisional; Region: PRK11071 199310010058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 199310010059 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 199310010060 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 199310010061 active site 199310010062 metal binding site [ion binding]; metal-binding site 199310010063 hexamer interface [polypeptide binding]; other site 199310010064 putative dehydrogenase; Provisional; Region: PRK11039 199310010065 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 199310010066 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 199310010067 dimer interface [polypeptide binding]; other site 199310010068 ADP-ribose binding site [chemical binding]; other site 199310010069 active site 199310010070 nudix motif; other site 199310010071 metal binding site [ion binding]; metal-binding site 199310010072 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 199310010073 hypothetical protein; Provisional; Region: PRK11653 199310010074 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 199310010075 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 199310010076 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 199310010077 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 199310010078 catalytic residues [active] 199310010079 hinge region; other site 199310010080 alpha helical domain; other site 199310010081 putative disulfide oxidoreductase; Provisional; Region: PRK04307 199310010082 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 199310010083 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 199310010084 putative active site [active] 199310010085 metal binding site [ion binding]; metal-binding site 199310010086 zinc transporter ZupT; Provisional; Region: PRK04201 199310010087 ZIP Zinc transporter; Region: Zip; pfam02535 199310010088 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 199310010089 putative fimbrial protein; Provisional; Region: PRK09733 199310010090 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 199310010091 PapC N-terminal domain; Region: PapC_N; pfam13954 199310010092 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310010093 PapC C-terminal domain; Region: PapC_C; pfam13953 199310010094 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 199310010095 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310010096 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310010097 Fimbrial protein; Region: Fimbrial; pfam00419 199310010098 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 199310010099 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 199310010100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 199310010101 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 199310010102 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 199310010103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 199310010104 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 199310010105 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 199310010106 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 199310010107 putative ribose interaction site [chemical binding]; other site 199310010108 putative ADP binding site [chemical binding]; other site 199310010109 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 199310010110 active site 199310010111 nucleotide binding site [chemical binding]; other site 199310010112 HIGH motif; other site 199310010113 KMSKS motif; other site 199310010114 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 199310010115 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 199310010116 metal binding triad; other site 199310010117 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 199310010118 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 199310010119 metal binding triad; other site 199310010120 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 199310010121 Uncharacterized conserved protein [Function unknown]; Region: COG3025 199310010122 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 199310010123 putative active site [active] 199310010124 putative metal binding residues [ion binding]; other site 199310010125 signature motif; other site 199310010126 putative triphosphate binding site [ion binding]; other site 199310010127 CHAD domain; Region: CHAD; pfam05235 199310010128 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310010129 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 199310010130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 199310010131 Probable transposase; Region: OrfB_IS605; pfam01385 199310010132 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 199310010133 SH3 domain-containing protein; Provisional; Region: PRK10884 199310010134 Bacterial SH3 domain homologues; Region: SH3b; smart00287 199310010135 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 199310010136 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 199310010137 active site 199310010138 NTP binding site [chemical binding]; other site 199310010139 metal binding triad [ion binding]; metal-binding site 199310010140 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 199310010141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 199310010142 Zn2+ binding site [ion binding]; other site 199310010143 Mg2+ binding site [ion binding]; other site 199310010144 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 199310010145 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 199310010146 homooctamer interface [polypeptide binding]; other site 199310010147 active site 199310010148 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 199310010149 transcriptional activator TtdR; Provisional; Region: PRK09801 199310010150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310010151 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 199310010152 putative effector binding pocket; other site 199310010153 putative dimerization interface [polypeptide binding]; other site 199310010154 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 199310010155 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 199310010156 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 199310010157 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 199310010158 transmembrane helices; other site 199310010159 UGMP family protein; Validated; Region: PRK09604 199310010160 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 199310010161 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 199310010162 DNA primase; Validated; Region: dnaG; PRK05667 199310010163 CHC2 zinc finger; Region: zf-CHC2; pfam01807 199310010164 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 199310010165 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 199310010166 active site 199310010167 metal binding site [ion binding]; metal-binding site 199310010168 interdomain interaction site; other site 199310010169 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 199310010170 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 199310010171 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 199310010172 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 199310010173 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 199310010174 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 199310010175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 199310010176 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 199310010177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 199310010178 DNA binding residues [nucleotide binding] 199310010179 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 199310010180 active site 199310010181 SUMO-1 interface [polypeptide binding]; other site 199310010182 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 199310010183 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 199310010184 FAD binding pocket [chemical binding]; other site 199310010185 FAD binding motif [chemical binding]; other site 199310010186 phosphate binding motif [ion binding]; other site 199310010187 NAD binding pocket [chemical binding]; other site 199310010188 Predicted transcriptional regulators [Transcription]; Region: COG1695 199310010189 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 199310010190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310010191 PAS fold; Region: PAS_3; pfam08447 199310010192 putative active site [active] 199310010193 heme pocket [chemical binding]; other site 199310010194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 199310010195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 199310010196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 199310010197 dimer interface [polypeptide binding]; other site 199310010198 putative CheW interface [polypeptide binding]; other site 199310010199 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 199310010200 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 199310010201 inhibitor-cofactor binding pocket; inhibition site 199310010202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310010203 catalytic residue [active] 199310010204 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 199310010205 dimer interface [polypeptide binding]; other site 199310010206 putative tRNA-binding site [nucleotide binding]; other site 199310010207 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 199310010208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310010209 DNA binding site [nucleotide binding] 199310010210 domain linker motif; other site 199310010211 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 199310010212 putative dimerization interface [polypeptide binding]; other site 199310010213 putative ligand binding site [chemical binding]; other site 199310010214 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 199310010215 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 199310010216 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 199310010217 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 199310010218 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 199310010219 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 199310010220 inner membrane transporter YjeM; Provisional; Region: PRK15238 199310010221 alpha-glucosidase; Provisional; Region: PRK10137 199310010222 Protein of unknown function, DUF608; Region: DUF608; pfam04685 199310010223 Trehalase; Region: Trehalase; cl17346 199310010224 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 199310010225 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 199310010226 active site 199310010227 FMN binding site [chemical binding]; other site 199310010228 2,4-decadienoyl-CoA binding site; other site 199310010229 catalytic residue [active] 199310010230 4Fe-4S cluster binding site [ion binding]; other site 199310010231 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 199310010232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310010233 non-specific DNA binding site [nucleotide binding]; other site 199310010234 salt bridge; other site 199310010235 sequence-specific DNA binding site [nucleotide binding]; other site 199310010236 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 199310010237 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 199310010238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310010239 S-adenosylmethionine binding site [chemical binding]; other site 199310010240 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 199310010241 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 199310010242 putative active site [active] 199310010243 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 199310010244 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 199310010245 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 199310010246 serine/threonine transporter SstT; Provisional; Region: PRK13628 199310010247 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 199310010248 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 199310010249 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 199310010250 galactarate dehydratase; Region: galactar-dH20; TIGR03248 199310010251 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 199310010252 Glucuronate isomerase; Region: UxaC; pfam02614 199310010253 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 199310010254 D-galactonate transporter; Region: 2A0114; TIGR00893 199310010255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310010256 putative substrate translocation pore; other site 199310010257 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 199310010258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310010259 DNA-binding site [nucleotide binding]; DNA binding site 199310010260 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310010261 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 199310010262 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 199310010263 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 199310010264 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 199310010265 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 199310010266 Predicted membrane protein [Function unknown]; Region: COG5393 199310010267 YqjK-like protein; Region: YqjK; pfam13997 199310010268 Predicted membrane protein [Function unknown]; Region: COG2259 199310010269 Predicted membrane protein [Function unknown]; Region: COG3152 199310010270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310010271 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 199310010272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310010273 dimerization interface [polypeptide binding]; other site 199310010274 Pirin-related protein [General function prediction only]; Region: COG1741 199310010275 Pirin; Region: Pirin; pfam02678 199310010276 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 199310010277 L-serine dehydratase TdcG; Provisional; Region: PRK15040 199310010278 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 199310010279 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 199310010280 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 199310010281 homotrimer interaction site [polypeptide binding]; other site 199310010282 putative active site [active] 199310010283 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 199310010284 Pyruvate formate lyase 1; Region: PFL1; cd01678 199310010285 coenzyme A binding site [chemical binding]; other site 199310010286 active site 199310010287 catalytic residues [active] 199310010288 glycine loop; other site 199310010289 Acetokinase family; Region: Acetate_kinase; cl17229 199310010290 threonine/serine transporter TdcC; Provisional; Region: PRK13629 199310010291 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 199310010292 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 199310010293 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 199310010294 tetramer interface [polypeptide binding]; other site 199310010295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310010296 catalytic residue [active] 199310010297 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 199310010298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310010299 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 199310010300 putative substrate binding pocket [chemical binding]; other site 199310010301 putative dimerization interface [polypeptide binding]; other site 199310010302 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 199310010303 glycerate kinase I; Provisional; Region: PRK10342 199310010304 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 199310010305 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 199310010306 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 199310010307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310010308 D-galactonate transporter; Region: 2A0114; TIGR00893 199310010309 putative substrate translocation pore; other site 199310010310 galactarate dehydratase; Region: galactar-dH20; TIGR03248 199310010311 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 199310010312 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 199310010313 putative regulator PrlF; Provisional; Region: PRK09974 199310010314 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 199310010315 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 199310010316 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 199310010317 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 199310010318 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310010319 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 199310010320 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 199310010321 active site 199310010322 phosphorylation site [posttranslational modification] 199310010323 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 199310010324 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 199310010325 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 199310010326 active pocket/dimerization site; other site 199310010327 active site 199310010328 phosphorylation site [posttranslational modification] 199310010329 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 199310010330 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 199310010331 active site 199310010332 dimer interface [polypeptide binding]; other site 199310010333 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 199310010334 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 199310010335 dimer interface [polypeptide binding]; other site 199310010336 active site 199310010337 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 199310010338 putative active site [active] 199310010339 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 199310010340 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 199310010341 active site 199310010342 intersubunit interface [polypeptide binding]; other site 199310010343 zinc binding site [ion binding]; other site 199310010344 Na+ binding site [ion binding]; other site 199310010345 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 199310010346 active site 199310010347 phosphorylation site [posttranslational modification] 199310010348 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 199310010349 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 199310010350 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 199310010351 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 199310010352 active site 199310010353 trimer interface [polypeptide binding]; other site 199310010354 allosteric site; other site 199310010355 active site lid [active] 199310010356 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 199310010357 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 199310010358 putative SAM binding site [chemical binding]; other site 199310010359 putative homodimer interface [polypeptide binding]; other site 199310010360 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 199310010361 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 199310010362 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 199310010363 putative ligand binding site [chemical binding]; other site 199310010364 TIGR00252 family protein; Region: TIGR00252 199310010365 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 199310010366 dimer interface [polypeptide binding]; other site 199310010367 active site 199310010368 outer membrane lipoprotein; Provisional; Region: PRK11023 199310010369 BON domain; Region: BON; pfam04972 199310010370 BON domain; Region: BON; pfam04972 199310010371 Predicted permease; Region: DUF318; pfam03773 199310010372 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 199310010373 NADH(P)-binding; Region: NAD_binding_10; pfam13460 199310010374 NAD binding site [chemical binding]; other site 199310010375 active site 199310010376 hypothetical protein; Provisional; Region: PRK03467 199310010377 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 199310010378 GIY-YIG motif/motif A; other site 199310010379 putative active site [active] 199310010380 putative metal binding site [ion binding]; other site 199310010381 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 199310010382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310010383 Coenzyme A binding pocket [chemical binding]; other site 199310010384 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 199310010385 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 199310010386 Peptidase family U32; Region: Peptidase_U32; pfam01136 199310010387 putative protease; Provisional; Region: PRK15447 199310010388 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 199310010389 hypothetical protein; Provisional; Region: PRK10508 199310010390 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 199310010391 tryptophan permease; Provisional; Region: PRK10483 199310010392 aromatic amino acid transport protein; Region: araaP; TIGR00837 199310010393 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 199310010394 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 199310010395 ATP binding site [chemical binding]; other site 199310010396 Mg++ binding site [ion binding]; other site 199310010397 motif III; other site 199310010398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310010399 nucleotide binding region [chemical binding]; other site 199310010400 ATP-binding site [chemical binding]; other site 199310010401 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 199310010402 putative RNA binding site [nucleotide binding]; other site 199310010403 lipoprotein NlpI; Provisional; Region: PRK11189 199310010404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310010405 binding surface 199310010406 TPR motif; other site 199310010407 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 199310010408 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 199310010409 RNase E interface [polypeptide binding]; other site 199310010410 trimer interface [polypeptide binding]; other site 199310010411 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 199310010412 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 199310010413 RNase E interface [polypeptide binding]; other site 199310010414 trimer interface [polypeptide binding]; other site 199310010415 active site 199310010416 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 199310010417 putative nucleic acid binding region [nucleotide binding]; other site 199310010418 G-X-X-G motif; other site 199310010419 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 199310010420 RNA binding site [nucleotide binding]; other site 199310010421 domain interface; other site 199310010422 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 199310010423 16S/18S rRNA binding site [nucleotide binding]; other site 199310010424 S13e-L30e interaction site [polypeptide binding]; other site 199310010425 25S rRNA binding site [nucleotide binding]; other site 199310010426 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 199310010427 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 199310010428 RNA binding site [nucleotide binding]; other site 199310010429 active site 199310010430 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 199310010431 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 199310010432 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 199310010433 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 199310010434 translation initiation factor IF-2; Region: IF-2; TIGR00487 199310010435 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 199310010436 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 199310010437 G1 box; other site 199310010438 putative GEF interaction site [polypeptide binding]; other site 199310010439 GTP/Mg2+ binding site [chemical binding]; other site 199310010440 Switch I region; other site 199310010441 G2 box; other site 199310010442 G3 box; other site 199310010443 Switch II region; other site 199310010444 G4 box; other site 199310010445 G5 box; other site 199310010446 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 199310010447 Translation-initiation factor 2; Region: IF-2; pfam11987 199310010448 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 199310010449 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 199310010450 NusA N-terminal domain; Region: NusA_N; pfam08529 199310010451 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 199310010452 RNA binding site [nucleotide binding]; other site 199310010453 homodimer interface [polypeptide binding]; other site 199310010454 NusA-like KH domain; Region: KH_5; pfam13184 199310010455 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 199310010456 G-X-X-G motif; other site 199310010457 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 199310010458 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 199310010459 ribosome maturation protein RimP; Reviewed; Region: PRK00092 199310010460 Sm and related proteins; Region: Sm_like; cl00259 199310010461 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 199310010462 putative oligomer interface [polypeptide binding]; other site 199310010463 putative RNA binding site [nucleotide binding]; other site 199310010464 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 199310010465 ANP binding site [chemical binding]; other site 199310010466 Substrate Binding Site II [chemical binding]; other site 199310010467 Substrate Binding Site I [chemical binding]; other site 199310010468 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 199310010469 Sulfatase; Region: Sulfatase; pfam00884 199310010470 Preprotein translocase SecG subunit; Region: SecG; pfam03840 199310010471 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 199310010472 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 199310010473 active site 199310010474 substrate binding site [chemical binding]; other site 199310010475 metal binding site [ion binding]; metal-binding site 199310010476 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 199310010477 dihydropteroate synthase; Region: DHPS; TIGR01496 199310010478 substrate binding pocket [chemical binding]; other site 199310010479 dimer interface [polypeptide binding]; other site 199310010480 inhibitor binding site; inhibition site 199310010481 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 199310010482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310010483 S-adenosylmethionine binding site [chemical binding]; other site 199310010484 RNA-binding protein YhbY; Provisional; Region: PRK10343 199310010485 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 199310010486 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 199310010487 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 199310010488 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 199310010489 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 199310010490 GTPase CgtA; Reviewed; Region: obgE; PRK12298 199310010491 GTP1/OBG; Region: GTP1_OBG; pfam01018 199310010492 Obg GTPase; Region: Obg; cd01898 199310010493 G1 box; other site 199310010494 GTP/Mg2+ binding site [chemical binding]; other site 199310010495 Switch I region; other site 199310010496 G2 box; other site 199310010497 G3 box; other site 199310010498 Switch II region; other site 199310010499 G4 box; other site 199310010500 G5 box; other site 199310010501 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 199310010502 EamA-like transporter family; Region: EamA; pfam00892 199310010503 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 199310010504 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 199310010505 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 199310010506 substrate binding pocket [chemical binding]; other site 199310010507 chain length determination region; other site 199310010508 substrate-Mg2+ binding site; other site 199310010509 catalytic residues [active] 199310010510 aspartate-rich region 1; other site 199310010511 active site lid residues [active] 199310010512 aspartate-rich region 2; other site 199310010513 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 199310010514 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 199310010515 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 199310010516 hinge; other site 199310010517 active site 199310010518 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 199310010519 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 199310010520 anti sigma factor interaction site; other site 199310010521 regulatory phosphorylation site [posttranslational modification]; other site 199310010522 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 199310010523 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 199310010524 mce related protein; Region: MCE; pfam02470 199310010525 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 199310010526 conserved hypothetical integral membrane protein; Region: TIGR00056 199310010527 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 199310010528 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 199310010529 Walker A/P-loop; other site 199310010530 ATP binding site [chemical binding]; other site 199310010531 Q-loop/lid; other site 199310010532 ABC transporter signature motif; other site 199310010533 Walker B; other site 199310010534 D-loop; other site 199310010535 H-loop/switch region; other site 199310010536 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 199310010537 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 199310010538 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 199310010539 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 199310010540 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 199310010541 putative active site [active] 199310010542 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 199310010543 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 199310010544 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 199310010545 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 199310010546 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 199310010547 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 199310010548 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 199310010549 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 199310010550 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 199310010551 Walker A/P-loop; other site 199310010552 ATP binding site [chemical binding]; other site 199310010553 Q-loop/lid; other site 199310010554 ABC transporter signature motif; other site 199310010555 Walker B; other site 199310010556 D-loop; other site 199310010557 H-loop/switch region; other site 199310010558 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 199310010559 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 199310010560 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 199310010561 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 199310010562 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 199310010563 30S subunit binding site; other site 199310010564 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310010565 active site 199310010566 phosphorylation site [posttranslational modification] 199310010567 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 199310010568 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 199310010569 dimerization domain swap beta strand [polypeptide binding]; other site 199310010570 regulatory protein interface [polypeptide binding]; other site 199310010571 active site 199310010572 regulatory phosphorylation site [posttranslational modification]; other site 199310010573 hypothetical protein; Provisional; Region: PRK10345 199310010574 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 199310010575 Transglycosylase; Region: Transgly; cl17702 199310010576 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 199310010577 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 199310010578 conserved cys residue [active] 199310010579 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 199310010580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310010581 putative active site [active] 199310010582 heme pocket [chemical binding]; other site 199310010583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310010584 dimer interface [polypeptide binding]; other site 199310010585 phosphorylation site [posttranslational modification] 199310010586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310010587 ATP binding site [chemical binding]; other site 199310010588 Mg2+ binding site [ion binding]; other site 199310010589 G-X-G motif; other site 199310010590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310010591 active site 199310010592 phosphorylation site [posttranslational modification] 199310010593 intermolecular recognition site; other site 199310010594 dimerization interface [polypeptide binding]; other site 199310010595 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 199310010596 putative binding surface; other site 199310010597 active site 199310010598 radical SAM protein, TIGR01212 family; Region: TIGR01212 199310010599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310010600 FeS/SAM binding site; other site 199310010601 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 199310010602 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 199310010603 active site 199310010604 dimer interface [polypeptide binding]; other site 199310010605 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 199310010606 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 199310010607 active site 199310010608 FMN binding site [chemical binding]; other site 199310010609 substrate binding site [chemical binding]; other site 199310010610 3Fe-4S cluster binding site [ion binding]; other site 199310010611 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 199310010612 domain interface; other site 199310010613 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 199310010614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310010615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310010616 Domain of unknown function (DUF386); Region: DUF386; cl01047 199310010617 N-acetylmannosamine kinase; Provisional; Region: PRK05082 199310010618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310010619 nucleotide binding site [chemical binding]; other site 199310010620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 199310010621 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 199310010622 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 199310010623 putative active site cavity [active] 199310010624 putative sialic acid transporter; Provisional; Region: PRK03893 199310010625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310010626 putative substrate translocation pore; other site 199310010627 N-acetylneuraminate lyase; Region: nanA; TIGR00683 199310010628 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 199310010629 inhibitor site; inhibition site 199310010630 active site 199310010631 dimer interface [polypeptide binding]; other site 199310010632 catalytic residue [active] 199310010633 transcriptional regulator NanR; Provisional; Region: PRK03837 199310010634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310010635 DNA-binding site [nucleotide binding]; DNA binding site 199310010636 FCD domain; Region: FCD; pfam07729 199310010637 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 199310010638 stringent starvation protein A; Provisional; Region: sspA; PRK09481 199310010639 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 199310010640 C-terminal domain interface [polypeptide binding]; other site 199310010641 putative GSH binding site (G-site) [chemical binding]; other site 199310010642 dimer interface [polypeptide binding]; other site 199310010643 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 199310010644 dimer interface [polypeptide binding]; other site 199310010645 N-terminal domain interface [polypeptide binding]; other site 199310010646 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 199310010647 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 199310010648 23S rRNA interface [nucleotide binding]; other site 199310010649 L3 interface [polypeptide binding]; other site 199310010650 Predicted ATPase [General function prediction only]; Region: COG1485 199310010651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 199310010652 hypothetical protein; Provisional; Region: PRK11677 199310010653 serine endoprotease; Provisional; Region: PRK10139 199310010654 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 199310010655 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 199310010656 protein binding site [polypeptide binding]; other site 199310010657 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 199310010658 serine endoprotease; Provisional; Region: PRK10898 199310010659 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 199310010660 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 199310010661 malate dehydrogenase; Provisional; Region: PRK05086 199310010662 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 199310010663 NAD binding site [chemical binding]; other site 199310010664 dimerization interface [polypeptide binding]; other site 199310010665 Substrate binding site [chemical binding]; other site 199310010666 arginine repressor; Provisional; Region: PRK05066 199310010667 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 199310010668 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 199310010669 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310010670 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 199310010671 RNAase interaction site [polypeptide binding]; other site 199310010672 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 199310010673 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 199310010674 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 199310010675 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310010676 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310010677 efflux system membrane protein; Provisional; Region: PRK11594 199310010678 transcriptional regulator; Provisional; Region: PRK10632 199310010679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310010680 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 199310010681 putative effector binding pocket; other site 199310010682 dimerization interface [polypeptide binding]; other site 199310010683 protease TldD; Provisional; Region: tldD; PRK10735 199310010684 hypothetical protein; Provisional; Region: PRK10899 199310010685 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 199310010686 ribonuclease G; Provisional; Region: PRK11712 199310010687 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 199310010688 homodimer interface [polypeptide binding]; other site 199310010689 oligonucleotide binding site [chemical binding]; other site 199310010690 Maf-like protein; Region: Maf; pfam02545 199310010691 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 199310010692 active site 199310010693 dimer interface [polypeptide binding]; other site 199310010694 rod shape-determining protein MreD; Provisional; Region: PRK11060 199310010695 rod shape-determining protein MreC; Region: mreC; TIGR00219 199310010696 rod shape-determining protein MreC; Region: MreC; pfam04085 199310010697 rod shape-determining protein MreB; Provisional; Region: PRK13927 199310010698 MreB and similar proteins; Region: MreB_like; cd10225 199310010699 nucleotide binding site [chemical binding]; other site 199310010700 Mg binding site [ion binding]; other site 199310010701 putative protofilament interaction site [polypeptide binding]; other site 199310010702 RodZ interaction site [polypeptide binding]; other site 199310010703 regulatory protein CsrD; Provisional; Region: PRK11059 199310010704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310010705 metal binding site [ion binding]; metal-binding site 199310010706 active site 199310010707 I-site; other site 199310010708 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310010709 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 199310010710 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 199310010711 NADP binding site [chemical binding]; other site 199310010712 dimer interface [polypeptide binding]; other site 199310010713 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 199310010714 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 199310010715 carboxyltransferase (CT) interaction site; other site 199310010716 biotinylation site [posttranslational modification]; other site 199310010717 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 199310010718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 199310010719 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 199310010720 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 199310010721 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 199310010722 active site 199310010723 catalytic residues [active] 199310010724 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310010725 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 199310010726 substrate binding site [chemical binding]; other site 199310010727 ATP binding site [chemical binding]; other site 199310010728 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310010729 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310010730 TM-ABC transporter signature motif; other site 199310010731 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 199310010732 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 199310010733 Walker A/P-loop; other site 199310010734 ATP binding site [chemical binding]; other site 199310010735 Q-loop/lid; other site 199310010736 ABC transporter signature motif; other site 199310010737 Walker B; other site 199310010738 D-loop; other site 199310010739 H-loop/switch region; other site 199310010740 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310010741 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 199310010742 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 199310010743 putative ligand binding site [chemical binding]; other site 199310010744 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 199310010745 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 199310010746 intersubunit interface [polypeptide binding]; other site 199310010747 active site 199310010748 zinc binding site [ion binding]; other site 199310010749 Na+ binding site [ion binding]; other site 199310010750 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310010751 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 199310010752 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310010753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310010754 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 199310010755 substrate binding site [chemical binding]; other site 199310010756 ATP binding site [chemical binding]; other site 199310010757 hypothetical protein; Provisional; Region: PRK10633 199310010758 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 199310010759 Na binding site [ion binding]; other site 199310010760 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 199310010761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 199310010762 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 199310010763 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 199310010764 FMN binding site [chemical binding]; other site 199310010765 active site 199310010766 catalytic residues [active] 199310010767 substrate binding site [chemical binding]; other site 199310010768 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 199310010769 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 199310010770 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 199310010771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310010772 DNA methylase; Region: N6_N4_Mtase; pfam01555 199310010773 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 199310010774 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 199310010775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310010776 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 199310010777 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 199310010778 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310010779 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310010780 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 199310010781 Protein export membrane protein; Region: SecD_SecF; cl14618 199310010782 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 199310010783 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 199310010784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310010785 substrate binding pocket [chemical binding]; other site 199310010786 membrane-bound complex binding site; other site 199310010787 hinge residues; other site 199310010788 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 199310010789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310010790 conserved gate region; other site 199310010791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310010792 dimer interface [polypeptide binding]; other site 199310010793 conserved gate region; other site 199310010794 putative PBP binding loops; other site 199310010795 ABC-ATPase subunit interface; other site 199310010796 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 199310010797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310010798 dimer interface [polypeptide binding]; other site 199310010799 conserved gate region; other site 199310010800 putative PBP binding loops; other site 199310010801 ABC-ATPase subunit interface; other site 199310010802 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 199310010803 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 199310010804 Walker A/P-loop; other site 199310010805 ATP binding site [chemical binding]; other site 199310010806 Q-loop/lid; other site 199310010807 ABC transporter signature motif; other site 199310010808 Walker B; other site 199310010809 D-loop; other site 199310010810 H-loop/switch region; other site 199310010811 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 199310010812 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 199310010813 trimer interface [polypeptide binding]; other site 199310010814 putative metal binding site [ion binding]; other site 199310010815 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 199310010816 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 199310010817 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 199310010818 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 199310010819 shikimate binding site; other site 199310010820 NAD(P) binding site [chemical binding]; other site 199310010821 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 199310010822 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 199310010823 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 199310010824 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 199310010825 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 199310010826 hypothetical protein; Validated; Region: PRK03430 199310010827 hypothetical protein; Provisional; Region: PRK10736 199310010828 DNA protecting protein DprA; Region: dprA; TIGR00732 199310010829 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 199310010830 active site 199310010831 catalytic residues [active] 199310010832 metal binding site [ion binding]; metal-binding site 199310010833 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 199310010834 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 199310010835 putative active site [active] 199310010836 substrate binding site [chemical binding]; other site 199310010837 putative cosubstrate binding site; other site 199310010838 catalytic site [active] 199310010839 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 199310010840 substrate binding site [chemical binding]; other site 199310010841 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 199310010842 putative RNA binding site [nucleotide binding]; other site 199310010843 16S rRNA methyltransferase B; Provisional; Region: PRK10901 199310010844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310010845 S-adenosylmethionine binding site [chemical binding]; other site 199310010846 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 199310010847 TrkA-N domain; Region: TrkA_N; pfam02254 199310010848 TrkA-C domain; Region: TrkA_C; pfam02080 199310010849 TrkA-N domain; Region: TrkA_N; pfam02254 199310010850 TrkA-C domain; Region: TrkA_C; pfam02080 199310010851 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 199310010852 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 199310010853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 199310010854 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 199310010855 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 199310010856 DNA binding residues [nucleotide binding] 199310010857 dimer interface [polypeptide binding]; other site 199310010858 metal binding site [ion binding]; metal-binding site 199310010859 hypothetical protein; Provisional; Region: PRK10203 199310010860 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 199310010861 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 199310010862 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 199310010863 alphaNTD homodimer interface [polypeptide binding]; other site 199310010864 alphaNTD - beta interaction site [polypeptide binding]; other site 199310010865 alphaNTD - beta' interaction site [polypeptide binding]; other site 199310010866 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 199310010867 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 199310010868 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 199310010869 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310010870 RNA binding surface [nucleotide binding]; other site 199310010871 30S ribosomal protein S11; Validated; Region: PRK05309 199310010872 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 199310010873 30S ribosomal protein S13; Region: bact_S13; TIGR03631 199310010874 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 199310010875 SecY translocase; Region: SecY; pfam00344 199310010876 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 199310010877 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 199310010878 23S rRNA binding site [nucleotide binding]; other site 199310010879 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 199310010880 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 199310010881 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 199310010882 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 199310010883 23S rRNA interface [nucleotide binding]; other site 199310010884 5S rRNA interface [nucleotide binding]; other site 199310010885 L27 interface [polypeptide binding]; other site 199310010886 L5 interface [polypeptide binding]; other site 199310010887 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 199310010888 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 199310010889 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 199310010890 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 199310010891 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 199310010892 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 199310010893 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 199310010894 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 199310010895 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 199310010896 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 199310010897 RNA binding site [nucleotide binding]; other site 199310010898 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 199310010899 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 199310010900 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 199310010901 23S rRNA interface [nucleotide binding]; other site 199310010902 putative translocon interaction site; other site 199310010903 signal recognition particle (SRP54) interaction site; other site 199310010904 L23 interface [polypeptide binding]; other site 199310010905 trigger factor interaction site; other site 199310010906 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 199310010907 23S rRNA interface [nucleotide binding]; other site 199310010908 5S rRNA interface [nucleotide binding]; other site 199310010909 putative antibiotic binding site [chemical binding]; other site 199310010910 L25 interface [polypeptide binding]; other site 199310010911 L27 interface [polypeptide binding]; other site 199310010912 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 199310010913 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 199310010914 G-X-X-G motif; other site 199310010915 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 199310010916 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 199310010917 protein-rRNA interface [nucleotide binding]; other site 199310010918 putative translocon binding site; other site 199310010919 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 199310010920 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 199310010921 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 199310010922 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 199310010923 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 199310010924 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 199310010925 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 199310010926 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 199310010927 protein secretion protein GspB; Provisional; Region: PRK09697 199310010928 AAA domain; Region: AAA_22; pfam13401 199310010929 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 199310010930 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 199310010931 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 199310010932 type II secretion system protein D; Region: type_II_gspD; TIGR02517 199310010933 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 199310010934 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 199310010935 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 199310010936 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 199310010937 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 199310010938 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 199310010939 Walker A motif; other site 199310010940 ATP binding site [chemical binding]; other site 199310010941 Walker B motif; other site 199310010942 type II secretion system protein F; Region: GspF; TIGR02120 199310010943 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 199310010944 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 199310010945 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 199310010946 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 199310010947 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 199310010948 Type II transport protein GspH; Region: GspH; pfam12019 199310010949 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 199310010950 type II secretion system protein I; Region: gspI; TIGR01707 199310010951 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 199310010952 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 199310010953 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 199310010954 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 199310010955 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 199310010956 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 199310010957 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 199310010958 GspL periplasmic domain; Region: GspL_C; pfam12693 199310010959 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 199310010960 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 199310010961 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 199310010962 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 199310010963 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 199310010964 heme binding site [chemical binding]; other site 199310010965 ferroxidase pore; other site 199310010966 ferroxidase diiron center [ion binding]; other site 199310010967 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 199310010968 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 199310010969 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 199310010970 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 199310010971 aromatic chitin/cellulose binding site residues [chemical binding]; other site 199310010972 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 199310010973 active site 199310010974 elongation factor Tu; Reviewed; Region: PRK00049 199310010975 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 199310010976 G1 box; other site 199310010977 GEF interaction site [polypeptide binding]; other site 199310010978 GTP/Mg2+ binding site [chemical binding]; other site 199310010979 Switch I region; other site 199310010980 G2 box; other site 199310010981 G3 box; other site 199310010982 Switch II region; other site 199310010983 G4 box; other site 199310010984 G5 box; other site 199310010985 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 199310010986 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 199310010987 Antibiotic Binding Site [chemical binding]; other site 199310010988 elongation factor G; Reviewed; Region: PRK00007 199310010989 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 199310010990 G1 box; other site 199310010991 putative GEF interaction site [polypeptide binding]; other site 199310010992 GTP/Mg2+ binding site [chemical binding]; other site 199310010993 Switch I region; other site 199310010994 G2 box; other site 199310010995 G3 box; other site 199310010996 Switch II region; other site 199310010997 G4 box; other site 199310010998 G5 box; other site 199310010999 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 199310011000 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 199310011001 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 199310011002 30S ribosomal protein S7; Validated; Region: PRK05302 199310011003 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 199310011004 S17 interaction site [polypeptide binding]; other site 199310011005 S8 interaction site; other site 199310011006 16S rRNA interaction site [nucleotide binding]; other site 199310011007 streptomycin interaction site [chemical binding]; other site 199310011008 23S rRNA interaction site [nucleotide binding]; other site 199310011009 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 199310011010 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 199310011011 sulfur relay protein TusC; Validated; Region: PRK00211 199310011012 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 199310011013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 199310011014 YheO-like PAS domain; Region: PAS_6; pfam08348 199310011015 HTH domain; Region: HTH_22; pfam13309 199310011016 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 199310011017 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 199310011018 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 199310011019 phi X174 lysis protein; Provisional; Region: PRK02793 199310011020 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 199310011021 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 199310011022 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 199310011023 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 199310011024 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 199310011025 TrkA-N domain; Region: TrkA_N; pfam02254 199310011026 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 199310011027 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 199310011028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310011029 Walker A/P-loop; other site 199310011030 ATP binding site [chemical binding]; other site 199310011031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 199310011032 ABC transporter signature motif; other site 199310011033 Walker B; other site 199310011034 D-loop; other site 199310011035 ABC transporter; Region: ABC_tran_2; pfam12848 199310011036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 199310011037 putative hydrolase; Provisional; Region: PRK10985 199310011038 hypothetical protein; Provisional; Region: PRK04966 199310011039 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 199310011040 active site 199310011041 hypothetical protein; Provisional; Region: PRK10738 199310011042 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 199310011043 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 199310011044 ligand binding site [chemical binding]; other site 199310011045 flexible hinge region; other site 199310011046 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 199310011047 putative switch regulator; other site 199310011048 non-specific DNA interactions [nucleotide binding]; other site 199310011049 DNA binding site [nucleotide binding] 199310011050 sequence specific DNA binding site [nucleotide binding]; other site 199310011051 putative cAMP binding site [chemical binding]; other site 199310011052 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 199310011053 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 199310011054 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 199310011055 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 199310011056 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 199310011057 inhibitor-cofactor binding pocket; inhibition site 199310011058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310011059 catalytic residue [active] 199310011060 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 199310011061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 199310011062 glutamine binding [chemical binding]; other site 199310011063 catalytic triad [active] 199310011064 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 199310011065 cell filamentation protein Fic; Provisional; Region: PRK10347 199310011066 hypothetical protein; Provisional; Region: PRK10204 199310011067 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 199310011068 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 199310011069 substrate binding site [chemical binding]; other site 199310011070 putative transporter; Provisional; Region: PRK03699 199310011071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310011072 putative substrate translocation pore; other site 199310011073 nitrite reductase subunit NirD; Provisional; Region: PRK14989 199310011074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310011075 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 199310011076 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 199310011077 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 199310011078 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 199310011079 nitrite transporter NirC; Provisional; Region: PRK11562 199310011080 siroheme synthase; Provisional; Region: cysG; PRK10637 199310011081 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 199310011082 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 199310011083 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 199310011084 active site 199310011085 SAM binding site [chemical binding]; other site 199310011086 homodimer interface [polypeptide binding]; other site 199310011087 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 199310011088 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 199310011089 Protein of unknown function; Region: YhfT; pfam10797 199310011090 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 199310011091 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 199310011092 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 199310011093 active site 199310011094 substrate binding pocket [chemical binding]; other site 199310011095 homodimer interaction site [polypeptide binding]; other site 199310011096 putative mutase; Provisional; Region: PRK12383 199310011097 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 199310011098 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 199310011099 dimer interface [polypeptide binding]; other site 199310011100 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 199310011101 active site 199310011102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 199310011103 substrate binding site [chemical binding]; other site 199310011104 catalytic residue [active] 199310011105 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 199310011106 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 199310011107 active site 199310011108 HIGH motif; other site 199310011109 dimer interface [polypeptide binding]; other site 199310011110 KMSKS motif; other site 199310011111 phosphoglycolate phosphatase; Provisional; Region: PRK13222 199310011112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310011113 motif II; other site 199310011114 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 199310011115 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 199310011116 substrate binding site [chemical binding]; other site 199310011117 hexamer interface [polypeptide binding]; other site 199310011118 metal binding site [ion binding]; metal-binding site 199310011119 DNA adenine methylase; Provisional; Region: PRK10904 199310011120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 199310011121 cell division protein DamX; Validated; Region: PRK10905 199310011122 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 199310011123 active site 199310011124 dimer interface [polypeptide binding]; other site 199310011125 metal binding site [ion binding]; metal-binding site 199310011126 shikimate kinase; Reviewed; Region: aroK; PRK00131 199310011127 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 199310011128 ADP binding site [chemical binding]; other site 199310011129 magnesium binding site [ion binding]; other site 199310011130 putative shikimate binding site; other site 199310011131 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 199310011132 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 199310011133 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 199310011134 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 199310011135 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 199310011136 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 199310011137 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 199310011138 Transglycosylase; Region: Transgly; pfam00912 199310011139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 199310011140 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 199310011141 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 199310011142 ADP-ribose binding site [chemical binding]; other site 199310011143 dimer interface [polypeptide binding]; other site 199310011144 active site 199310011145 nudix motif; other site 199310011146 metal binding site [ion binding]; metal-binding site 199310011147 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 199310011148 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 199310011149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310011150 motif II; other site 199310011151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310011152 RNA binding surface [nucleotide binding]; other site 199310011153 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 199310011154 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 199310011155 dimerization interface [polypeptide binding]; other site 199310011156 domain crossover interface; other site 199310011157 redox-dependent activation switch; other site 199310011158 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 199310011159 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 199310011160 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 199310011161 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 199310011162 active site 199310011163 substrate-binding site [chemical binding]; other site 199310011164 metal-binding site [ion binding] 199310011165 ATP binding site [chemical binding]; other site 199310011166 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 199310011167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310011168 non-specific DNA binding site [nucleotide binding]; other site 199310011169 salt bridge; other site 199310011170 sequence-specific DNA binding site [nucleotide binding]; other site 199310011171 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 199310011172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310011173 dimerization interface [polypeptide binding]; other site 199310011174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310011175 dimer interface [polypeptide binding]; other site 199310011176 phosphorylation site [posttranslational modification] 199310011177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310011178 ATP binding site [chemical binding]; other site 199310011179 G-X-G motif; other site 199310011180 osmolarity response regulator; Provisional; Region: ompR; PRK09468 199310011181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310011182 active site 199310011183 phosphorylation site [posttranslational modification] 199310011184 intermolecular recognition site; other site 199310011185 dimerization interface [polypeptide binding]; other site 199310011186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310011187 DNA binding site [nucleotide binding] 199310011188 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 199310011189 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 199310011190 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 199310011191 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 199310011192 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 199310011193 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 199310011194 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 199310011195 RNA binding site [nucleotide binding]; other site 199310011196 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 199310011197 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 199310011198 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 199310011199 G1 box; other site 199310011200 GTP/Mg2+ binding site [chemical binding]; other site 199310011201 Switch I region; other site 199310011202 G2 box; other site 199310011203 G3 box; other site 199310011204 Switch II region; other site 199310011205 G4 box; other site 199310011206 G5 box; other site 199310011207 Nucleoside recognition; Region: Gate; pfam07670 199310011208 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 199310011209 Nucleoside recognition; Region: Gate; pfam07670 199310011210 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 199310011211 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 199310011212 carboxylesterase BioH; Provisional; Region: PRK10349 199310011213 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 199310011214 DNA utilization protein GntX; Provisional; Region: PRK11595 199310011215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310011216 active site 199310011217 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 199310011218 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 199310011219 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 199310011220 high-affinity gluconate transporter; Provisional; Region: PRK14984 199310011221 gluconate transporter; Region: gntP; TIGR00791 199310011222 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 199310011223 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 199310011224 maltodextrin phosphorylase; Provisional; Region: PRK14985 199310011225 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 199310011226 homodimer interface [polypeptide binding]; other site 199310011227 active site pocket [active] 199310011228 transcriptional regulator MalT; Provisional; Region: PRK04841 199310011229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310011230 DNA binding residues [nucleotide binding] 199310011231 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 199310011232 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 199310011233 putative active site [active] 199310011234 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 199310011235 hypothetical protein; Reviewed; Region: PRK09588 199310011236 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 199310011237 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 199310011238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310011239 Walker A motif; other site 199310011240 ATP binding site [chemical binding]; other site 199310011241 Walker B motif; other site 199310011242 arginine finger; other site 199310011243 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 199310011244 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 199310011245 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310011246 intramembrane serine protease GlpG; Provisional; Region: PRK10907 199310011247 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 199310011248 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 199310011249 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 199310011250 active site residue [active] 199310011251 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 199310011252 hypothetical protein; Provisional; Region: PRK09781; cl08057 199310011253 Fimbrial protein; Region: Fimbrial; cl01416 199310011254 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 199310011255 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310011256 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310011257 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310011258 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310011259 outer membrane usher protein; Provisional; Region: PRK15193 199310011260 PapC N-terminal domain; Region: PapC_N; pfam13954 199310011261 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310011262 PapC C-terminal domain; Region: PapC_C; pfam13953 199310011263 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 199310011264 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310011265 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310011266 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310011267 glycogen phosphorylase; Provisional; Region: PRK14986 199310011268 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 199310011269 homodimer interface [polypeptide binding]; other site 199310011270 active site pocket [active] 199310011271 glycogen synthase; Provisional; Region: glgA; PRK00654 199310011272 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 199310011273 ADP-binding pocket [chemical binding]; other site 199310011274 homodimer interface [polypeptide binding]; other site 199310011275 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 199310011276 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 199310011277 ligand binding site; other site 199310011278 oligomer interface; other site 199310011279 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 199310011280 sulfate 1 binding site; other site 199310011281 glycogen debranching enzyme; Provisional; Region: PRK03705 199310011282 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 199310011283 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 199310011284 active site 199310011285 catalytic site [active] 199310011286 glycogen branching enzyme; Provisional; Region: PRK05402 199310011287 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 199310011288 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 199310011289 active site 199310011290 catalytic site [active] 199310011291 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 199310011292 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 199310011293 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 199310011294 putative antibiotic transporter; Provisional; Region: PRK10739 199310011295 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 199310011296 DNA protecting protein DprA; Region: dprA; TIGR00732 199310011297 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 199310011298 non-specific DNA interactions [nucleotide binding]; other site 199310011299 DNA binding site [nucleotide binding] 199310011300 sequence specific DNA binding site [nucleotide binding]; other site 199310011301 putative cAMP binding site [chemical binding]; other site 199310011302 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 199310011303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310011304 ATP binding site [chemical binding]; other site 199310011305 putative Mg++ binding site [ion binding]; other site 199310011306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310011307 nucleotide binding region [chemical binding]; other site 199310011308 ATP-binding site [chemical binding]; other site 199310011309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310011310 active site 199310011311 low affinity gluconate transporter; Provisional; Region: PRK10472 199310011312 gluconate transporter; Region: gntP; TIGR00791 199310011313 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 199310011314 ATP-binding site [chemical binding]; other site 199310011315 Gluconate-6-phosphate binding site [chemical binding]; other site 199310011316 Shikimate kinase; Region: SKI; pfam01202 199310011317 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 199310011318 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310011319 DNA binding site [nucleotide binding] 199310011320 domain linker motif; other site 199310011321 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 199310011322 putative ligand binding site [chemical binding]; other site 199310011323 putative dimerization interface [polypeptide binding]; other site 199310011324 Pirin-related protein [General function prediction only]; Region: COG1741 199310011325 Pirin; Region: Pirin; pfam02678 199310011326 putative oxidoreductase; Provisional; Region: PRK10206 199310011327 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 199310011328 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 199310011329 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 199310011330 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 199310011331 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 199310011332 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 199310011333 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 199310011334 hypothetical protein; Provisional; Region: PRK10350 199310011335 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 199310011336 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 199310011337 putative active site [active] 199310011338 catalytic site [active] 199310011339 putative metal binding site [ion binding]; other site 199310011340 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 199310011341 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 199310011342 Walker A/P-loop; other site 199310011343 ATP binding site [chemical binding]; other site 199310011344 Q-loop/lid; other site 199310011345 ABC transporter signature motif; other site 199310011346 Walker B; other site 199310011347 D-loop; other site 199310011348 H-loop/switch region; other site 199310011349 TOBE domain; Region: TOBE_2; pfam08402 199310011350 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 199310011351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310011352 dimer interface [polypeptide binding]; other site 199310011353 conserved gate region; other site 199310011354 putative PBP binding loops; other site 199310011355 ABC-ATPase subunit interface; other site 199310011356 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 199310011357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310011358 dimer interface [polypeptide binding]; other site 199310011359 conserved gate region; other site 199310011360 putative PBP binding loops; other site 199310011361 ABC-ATPase subunit interface; other site 199310011362 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 199310011363 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 199310011364 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 199310011365 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 199310011366 Walker A/P-loop; other site 199310011367 ATP binding site [chemical binding]; other site 199310011368 Q-loop/lid; other site 199310011369 ABC transporter signature motif; other site 199310011370 Walker B; other site 199310011371 D-loop; other site 199310011372 H-loop/switch region; other site 199310011373 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 199310011374 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 199310011375 Walker A/P-loop; other site 199310011376 ATP binding site [chemical binding]; other site 199310011377 Q-loop/lid; other site 199310011378 ABC transporter signature motif; other site 199310011379 Walker B; other site 199310011380 D-loop; other site 199310011381 H-loop/switch region; other site 199310011382 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 199310011383 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 199310011384 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 199310011385 TM-ABC transporter signature motif; other site 199310011386 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310011387 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 199310011388 TM-ABC transporter signature motif; other site 199310011389 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 199310011390 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 199310011391 dimerization interface [polypeptide binding]; other site 199310011392 ligand binding site [chemical binding]; other site 199310011393 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 199310011394 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 199310011395 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 199310011396 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 199310011397 dimerization interface [polypeptide binding]; other site 199310011398 ligand binding site [chemical binding]; other site 199310011399 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 199310011400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 199310011401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 199310011402 DNA binding residues [nucleotide binding] 199310011403 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 199310011404 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 199310011405 cell division protein FtsE; Provisional; Region: PRK10908 199310011406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310011407 Walker A/P-loop; other site 199310011408 ATP binding site [chemical binding]; other site 199310011409 Q-loop/lid; other site 199310011410 ABC transporter signature motif; other site 199310011411 Walker B; other site 199310011412 D-loop; other site 199310011413 H-loop/switch region; other site 199310011414 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 199310011415 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 199310011416 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 199310011417 P loop; other site 199310011418 GTP binding site [chemical binding]; other site 199310011419 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 199310011420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310011421 S-adenosylmethionine binding site [chemical binding]; other site 199310011422 hypothetical protein; Provisional; Region: PRK10910 199310011423 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 199310011424 Predicted membrane protein [Function unknown]; Region: COG3714 199310011425 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 199310011426 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 199310011427 metal-binding site [ion binding] 199310011428 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 199310011429 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 199310011430 CPxP motif; other site 199310011431 hypothetical protein; Provisional; Region: PRK11212 199310011432 hypothetical protein; Provisional; Region: PRK11615 199310011433 major facilitator superfamily transporter; Provisional; Region: PRK05122 199310011434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310011435 putative substrate translocation pore; other site 199310011436 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 199310011437 Domain of unknown function DUF20; Region: UPF0118; pfam01594 199310011438 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 199310011439 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 199310011440 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 199310011441 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 199310011442 substrate binding site [chemical binding]; other site 199310011443 nickel transporter permease NikB; Provisional; Region: PRK10352 199310011444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310011445 dimer interface [polypeptide binding]; other site 199310011446 conserved gate region; other site 199310011447 putative PBP binding loops; other site 199310011448 ABC-ATPase subunit interface; other site 199310011449 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 199310011450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310011451 dimer interface [polypeptide binding]; other site 199310011452 conserved gate region; other site 199310011453 putative PBP binding loops; other site 199310011454 ABC-ATPase subunit interface; other site 199310011455 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 199310011456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310011457 Walker A/P-loop; other site 199310011458 ATP binding site [chemical binding]; other site 199310011459 Q-loop/lid; other site 199310011460 ABC transporter signature motif; other site 199310011461 Walker B; other site 199310011462 D-loop; other site 199310011463 H-loop/switch region; other site 199310011464 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 199310011465 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 199310011466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310011467 Walker A/P-loop; other site 199310011468 ATP binding site [chemical binding]; other site 199310011469 Q-loop/lid; other site 199310011470 ABC transporter signature motif; other site 199310011471 Walker B; other site 199310011472 D-loop; other site 199310011473 H-loop/switch region; other site 199310011474 nickel responsive regulator; Provisional; Region: PRK02967 199310011475 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 199310011476 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 199310011477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310011478 DNA-binding site [nucleotide binding]; DNA binding site 199310011479 UTRA domain; Region: UTRA; pfam07702 199310011480 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310011481 active site 199310011482 phosphorylation site [posttranslational modification] 199310011483 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 199310011484 active site 199310011485 P-loop; other site 199310011486 phosphorylation site [posttranslational modification] 199310011487 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 199310011488 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 199310011489 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 199310011490 putative N- and C-terminal domain interface [polypeptide binding]; other site 199310011491 D-xylulose kinase; Region: XylB; TIGR01312 199310011492 putative active site [active] 199310011493 putative MgATP binding site [chemical binding]; other site 199310011494 catalytic site [active] 199310011495 metal binding site [ion binding]; metal-binding site 199310011496 putative carbohydrate binding site [chemical binding]; other site 199310011497 seadornavirus RNA-directed RNA polymerase; Region: seadorna_RNAP; TIGR04234 199310011498 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 199310011499 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 199310011500 dimerization domain swap beta strand [polypeptide binding]; other site 199310011501 regulatory protein interface [polypeptide binding]; other site 199310011502 active site 199310011503 regulatory phosphorylation site [posttranslational modification]; other site 199310011504 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 199310011505 intersubunit interface [polypeptide binding]; other site 199310011506 active site 199310011507 zinc binding site [ion binding]; other site 199310011508 Na+ binding site [ion binding]; other site 199310011509 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 199310011510 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 199310011511 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 199310011512 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 199310011513 Walker A/P-loop; other site 199310011514 ATP binding site [chemical binding]; other site 199310011515 Q-loop/lid; other site 199310011516 ABC transporter signature motif; other site 199310011517 Walker B; other site 199310011518 D-loop; other site 199310011519 H-loop/switch region; other site 199310011520 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 199310011521 Walker A/P-loop; other site 199310011522 ATP binding site [chemical binding]; other site 199310011523 Q-loop/lid; other site 199310011524 ABC transporter signature motif; other site 199310011525 Walker B; other site 199310011526 D-loop; other site 199310011527 H-loop/switch region; other site 199310011528 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 199310011529 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 199310011530 HlyD family secretion protein; Region: HlyD; pfam00529 199310011531 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310011532 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310011533 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 199310011534 Predicted flavoproteins [General function prediction only]; Region: COG2081 199310011535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310011536 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 199310011537 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 199310011538 universal stress protein UspB; Provisional; Region: PRK04960 199310011539 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 199310011540 Ligand Binding Site [chemical binding]; other site 199310011541 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 199310011542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310011543 POT family; Region: PTR2; pfam00854 199310011544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310011545 S-adenosylmethionine binding site [chemical binding]; other site 199310011546 oligopeptidase A; Provisional; Region: PRK10911 199310011547 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 199310011548 active site 199310011549 Zn binding site [ion binding]; other site 199310011550 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 199310011551 glutathione reductase; Validated; Region: PRK06116 199310011552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 199310011553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310011554 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 199310011555 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 199310011556 ArsC family; Region: ArsC; pfam03960 199310011557 catalytic residues [active] 199310011558 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 199310011559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 199310011560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310011561 DNA binding residues [nucleotide binding] 199310011562 dimerization interface [polypeptide binding]; other site 199310011563 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 199310011564 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 199310011565 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 199310011566 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 199310011567 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310011568 N-terminal plug; other site 199310011569 ligand-binding site [chemical binding]; other site 199310011570 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 199310011571 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 199310011572 putative hemin binding site; other site 199310011573 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 199310011574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310011575 FeS/SAM binding site; other site 199310011576 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 199310011577 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 199310011578 NADH(P)-binding; Region: NAD_binding_10; pfam13460 199310011579 NAD(P) binding site [chemical binding]; other site 199310011580 putative active site [active] 199310011581 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 199310011582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 199310011583 ABC-ATPase subunit interface; other site 199310011584 dimer interface [polypeptide binding]; other site 199310011585 putative PBP binding regions; other site 199310011586 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 199310011587 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 199310011588 Walker A/P-loop; other site 199310011589 ATP binding site [chemical binding]; other site 199310011590 Q-loop/lid; other site 199310011591 ABC transporter signature motif; other site 199310011592 Walker B; other site 199310011593 D-loop; other site 199310011594 H-loop/switch region; other site 199310011595 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 199310011596 MgtC family; Region: MgtC; pfam02308 199310011597 acid-resistance protein; Provisional; Region: hdeB; PRK11566 199310011598 acid-resistance protein; Provisional; Region: PRK10208 199310011599 acid-resistance membrane protein; Provisional; Region: PRK10209 199310011600 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 199310011601 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 199310011602 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 199310011603 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310011604 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310011605 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 199310011606 Protein export membrane protein; Region: SecD_SecF; cl14618 199310011607 transcriptional regulator YdeO; Provisional; Region: PRK09940 199310011608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310011609 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 199310011610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310011611 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 199310011612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310011613 catalytic residue [active] 199310011614 Haem-binding domain; Region: Haem_bd; pfam14376 199310011615 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 199310011616 trehalase; Provisional; Region: treF; PRK13270 199310011617 Trehalase; Region: Trehalase; pfam01204 199310011618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 199310011619 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310011620 DNA binding residues [nucleotide binding] 199310011621 dimerization interface [polypeptide binding]; other site 199310011622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310011623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310011624 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 199310011625 putative effector binding pocket; other site 199310011626 putative dimerization interface [polypeptide binding]; other site 199310011627 inner membrane protein YhjD; Region: TIGR00766 199310011628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310011629 metabolite-proton symporter; Region: 2A0106; TIGR00883 199310011630 putative substrate translocation pore; other site 199310011631 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 199310011632 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 199310011633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310011634 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310011635 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 199310011636 substrate binding site [chemical binding]; other site 199310011637 ATP binding site [chemical binding]; other site 199310011638 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 199310011639 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 199310011640 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 199310011641 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 199310011642 putative diguanylate cyclase; Provisional; Region: PRK13561 199310011643 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 199310011644 metal binding site [ion binding]; metal-binding site 199310011645 active site 199310011646 I-site; other site 199310011647 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310011648 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 199310011649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310011650 binding surface 199310011651 TPR motif; other site 199310011652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310011653 binding surface 199310011654 TPR motif; other site 199310011655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 199310011656 TPR motif; other site 199310011657 binding surface 199310011658 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 199310011659 endo-1,4-D-glucanase; Provisional; Region: PRK11097 199310011660 cellulose synthase regulator protein; Provisional; Region: PRK11114 199310011661 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 199310011662 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 199310011663 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 199310011664 DXD motif; other site 199310011665 PilZ domain; Region: PilZ; pfam07238 199310011666 cell division protein; Provisional; Region: PRK10037 199310011667 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 199310011668 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 199310011669 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 199310011670 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 199310011671 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 199310011672 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 199310011673 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 199310011674 serine transporter; Region: stp; TIGR00814 199310011675 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 199310011676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310011677 Walker A/P-loop; other site 199310011678 ATP binding site [chemical binding]; other site 199310011679 Q-loop/lid; other site 199310011680 ABC transporter signature motif; other site 199310011681 Walker B; other site 199310011682 D-loop; other site 199310011683 H-loop/switch region; other site 199310011684 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 199310011685 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 199310011686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310011687 Walker A/P-loop; other site 199310011688 ATP binding site [chemical binding]; other site 199310011689 Q-loop/lid; other site 199310011690 ABC transporter signature motif; other site 199310011691 Walker B; other site 199310011692 D-loop; other site 199310011693 H-loop/switch region; other site 199310011694 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 199310011695 dipeptide transporter; Provisional; Region: PRK10913 199310011696 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 199310011697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310011698 dimer interface [polypeptide binding]; other site 199310011699 conserved gate region; other site 199310011700 putative PBP binding loops; other site 199310011701 ABC-ATPase subunit interface; other site 199310011702 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 199310011703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310011704 dimer interface [polypeptide binding]; other site 199310011705 conserved gate region; other site 199310011706 putative PBP binding loops; other site 199310011707 ABC-ATPase subunit interface; other site 199310011708 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 199310011709 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 199310011710 peptide binding site [polypeptide binding]; other site 199310011711 phosphoethanolamine transferase; Provisional; Region: PRK11560 199310011712 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 199310011713 Sulfatase; Region: Sulfatase; pfam00884 199310011714 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 199310011715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310011716 putative substrate translocation pore; other site 199310011717 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 199310011718 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 199310011719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 199310011720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310011721 Coenzyme A binding pocket [chemical binding]; other site 199310011722 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 199310011723 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 199310011724 molybdopterin cofactor binding site [chemical binding]; other site 199310011725 substrate binding site [chemical binding]; other site 199310011726 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 199310011727 molybdopterin cofactor binding site; other site 199310011728 putative outer membrane lipoprotein; Provisional; Region: PRK10510 199310011729 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 199310011730 ligand binding site [chemical binding]; other site 199310011731 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 199310011732 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 199310011733 dimerization interface [polypeptide binding]; other site 199310011734 ligand binding site [chemical binding]; other site 199310011735 NADP binding site [chemical binding]; other site 199310011736 catalytic site [active] 199310011737 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 199310011738 Predicted transcriptional regulator [Transcription]; Region: COG2944 199310011739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310011740 non-specific DNA binding site [nucleotide binding]; other site 199310011741 salt bridge; other site 199310011742 sequence-specific DNA binding site [nucleotide binding]; other site 199310011743 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 199310011744 DNA-binding site [nucleotide binding]; DNA binding site 199310011745 RNA-binding motif; other site 199310011746 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 199310011747 DALR anticodon binding domain; Region: DALR_1; pfam05746 199310011748 anticodon binding site; other site 199310011749 tRNA binding surface [nucleotide binding]; other site 199310011750 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 199310011751 dimer interface [polypeptide binding]; other site 199310011752 motif 1; other site 199310011753 active site 199310011754 motif 2; other site 199310011755 motif 3; other site 199310011756 YsaB-like lipoprotein; Region: YsaB; pfam13983 199310011757 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 199310011758 Acyltransferase family; Region: Acyl_transf_3; pfam01757 199310011759 hypothetical protein; Provisional; Region: PRK11383 199310011760 yiaA/B two helix domain; Region: YiaAB; pfam05360 199310011761 yiaA/B two helix domain; Region: YiaAB; pfam05360 199310011762 hypothetical protein; Provisional; Region: PRK11403 199310011763 yiaA/B two helix domain; Region: YiaAB; pfam05360 199310011764 xylulokinase; Provisional; Region: PRK15027 199310011765 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 199310011766 N- and C-terminal domain interface [polypeptide binding]; other site 199310011767 active site 199310011768 MgATP binding site [chemical binding]; other site 199310011769 catalytic site [active] 199310011770 metal binding site [ion binding]; metal-binding site 199310011771 xylulose binding site [chemical binding]; other site 199310011772 homodimer interface [polypeptide binding]; other site 199310011773 xylose isomerase; Provisional; Region: PRK05474 199310011774 xylose isomerase; Region: xylose_isom_A; TIGR02630 199310011775 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 199310011776 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 199310011777 putative ligand binding site [chemical binding]; other site 199310011778 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 199310011779 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 199310011780 Walker A/P-loop; other site 199310011781 ATP binding site [chemical binding]; other site 199310011782 Q-loop/lid; other site 199310011783 ABC transporter signature motif; other site 199310011784 Walker B; other site 199310011785 D-loop; other site 199310011786 H-loop/switch region; other site 199310011787 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310011788 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310011789 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310011790 TM-ABC transporter signature motif; other site 199310011791 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 199310011792 putative dimerization interface [polypeptide binding]; other site 199310011793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 199310011794 putative ligand binding site [chemical binding]; other site 199310011795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310011796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310011797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310011798 hypothetical protein; Provisional; Region: PRK10356 199310011799 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 199310011800 alpha-amylase; Reviewed; Region: malS; PRK09505 199310011801 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 199310011802 active site 199310011803 catalytic site [active] 199310011804 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 199310011805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310011806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310011807 homodimer interface [polypeptide binding]; other site 199310011808 catalytic residue [active] 199310011809 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 199310011810 Transcriptional regulator [Transcription]; Region: IclR; COG1414 199310011811 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 199310011812 Bacterial transcriptional regulator; Region: IclR; pfam01614 199310011813 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 199310011814 Domain of unknown function (DUF386); Region: DUF386; pfam04074 199310011815 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 199310011816 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 199310011817 DctM-like transporters; Region: DctM; pfam06808 199310011818 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 199310011819 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 199310011820 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 199310011821 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 199310011822 putative N- and C-terminal domain interface [polypeptide binding]; other site 199310011823 putative active site [active] 199310011824 MgATP binding site [chemical binding]; other site 199310011825 catalytic site [active] 199310011826 metal binding site [ion binding]; metal-binding site 199310011827 putative xylulose binding site [chemical binding]; other site 199310011828 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 199310011829 active site 199310011830 dimer interface [polypeptide binding]; other site 199310011831 magnesium binding site [ion binding]; other site 199310011832 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 199310011833 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 199310011834 AP (apurinic/apyrimidinic) site pocket; other site 199310011835 DNA interaction; other site 199310011836 Metal-binding active site; metal-binding site 199310011837 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 199310011838 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 199310011839 intersubunit interface [polypeptide binding]; other site 199310011840 active site 199310011841 Zn2+ binding site [ion binding]; other site 199310011842 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 199310011843 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 199310011844 NAD(P) binding site [chemical binding]; other site 199310011845 catalytic residues [active] 199310011846 Fic family protein [Function unknown]; Region: COG3177 199310011847 Fic/DOC family; Region: Fic; pfam02661 199310011848 putative alcohol dehydrogenase; Provisional; Region: PRK09860 199310011849 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 199310011850 dimer interface [polypeptide binding]; other site 199310011851 active site 199310011852 metal binding site [ion binding]; metal-binding site 199310011853 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 199310011854 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 199310011855 G1 box; other site 199310011856 putative GEF interaction site [polypeptide binding]; other site 199310011857 GTP/Mg2+ binding site [chemical binding]; other site 199310011858 Switch I region; other site 199310011859 G2 box; other site 199310011860 G3 box; other site 199310011861 Switch II region; other site 199310011862 G4 box; other site 199310011863 G5 box; other site 199310011864 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 199310011865 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 199310011866 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 199310011867 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 199310011868 selenocysteine synthase; Provisional; Region: PRK04311 199310011869 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 199310011870 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 199310011871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 199310011872 catalytic residue [active] 199310011873 putative glutathione S-transferase; Provisional; Region: PRK10357 199310011874 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 199310011875 putative C-terminal domain interface [polypeptide binding]; other site 199310011876 putative GSH binding site (G-site) [chemical binding]; other site 199310011877 putative dimer interface [polypeptide binding]; other site 199310011878 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 199310011879 dimer interface [polypeptide binding]; other site 199310011880 N-terminal domain interface [polypeptide binding]; other site 199310011881 putative substrate binding pocket (H-site) [chemical binding]; other site 199310011882 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 199310011883 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310011884 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310011885 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 199310011886 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 199310011887 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 199310011888 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 199310011889 active site 199310011890 P-loop; other site 199310011891 phosphorylation site [posttranslational modification] 199310011892 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310011893 active site 199310011894 phosphorylation site [posttranslational modification] 199310011895 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 199310011896 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 199310011897 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 199310011898 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 199310011899 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 199310011900 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 199310011901 hypothetical protein; Provisional; Region: PRK11020 199310011902 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 199310011903 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 199310011904 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 199310011905 trimer interface [polypeptide binding]; other site 199310011906 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 199310011907 trimer interface [polypeptide binding]; other site 199310011908 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 199310011909 Haemagglutinin; Region: HIM; pfam05662 199310011910 Haemagglutinin; Region: HIM; pfam05662 199310011911 YadA-like C-terminal region; Region: YadA; pfam03895 199310011912 L-lactate permease; Provisional; Region: PRK10420 199310011913 glycolate transporter; Provisional; Region: PRK09695 199310011914 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 199310011915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310011916 DNA-binding site [nucleotide binding]; DNA binding site 199310011917 FCD domain; Region: FCD; pfam07729 199310011918 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 199310011919 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 199310011920 phosphate binding site [ion binding]; other site 199310011921 putative rRNA methylase; Provisional; Region: PRK10358 199310011922 serine acetyltransferase; Provisional; Region: cysE; PRK11132 199310011923 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 199310011924 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 199310011925 trimer interface [polypeptide binding]; other site 199310011926 active site 199310011927 substrate binding site [chemical binding]; other site 199310011928 CoA binding site [chemical binding]; other site 199310011929 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 199310011930 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 199310011931 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 199310011932 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 199310011933 SecA binding site; other site 199310011934 Preprotein binding site; other site 199310011935 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 199310011936 GSH binding site [chemical binding]; other site 199310011937 catalytic residues [active] 199310011938 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 199310011939 active site residue [active] 199310011940 phosphoglyceromutase; Provisional; Region: PRK05434 199310011941 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 199310011942 AmiB activator; Provisional; Region: PRK11637 199310011943 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 199310011944 Peptidase family M23; Region: Peptidase_M23; pfam01551 199310011945 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 199310011946 NodB motif; other site 199310011947 putative active site [active] 199310011948 putative catalytic site [active] 199310011949 Zn binding site [ion binding]; other site 199310011950 putative glycosyl transferase; Provisional; Region: PRK10073 199310011951 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 199310011952 active site 199310011953 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 199310011954 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 199310011955 NAD(P) binding site [chemical binding]; other site 199310011956 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 199310011957 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 199310011958 substrate-cofactor binding pocket; other site 199310011959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310011960 catalytic residue [active] 199310011961 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 199310011962 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 199310011963 NADP binding site [chemical binding]; other site 199310011964 homopentamer interface [polypeptide binding]; other site 199310011965 substrate binding site [chemical binding]; other site 199310011966 active site 199310011967 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 199310011968 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 199310011969 putative active site [active] 199310011970 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 199310011971 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 199310011972 putative active site [active] 199310011973 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 199310011974 O-Antigen ligase; Region: Wzy_C; pfam04932 199310011975 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 199310011976 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 199310011977 active site 199310011978 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 199310011979 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 199310011980 Ligand binding site; other site 199310011981 metal-binding site 199310011982 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 199310011983 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 199310011984 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 199310011985 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 199310011986 Ligand binding site; other site 199310011987 metal-binding site 199310011988 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 199310011989 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 199310011990 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 199310011991 Ligand binding site; other site 199310011992 metal-binding site 199310011993 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 199310011994 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 199310011995 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 199310011996 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 199310011997 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 199310011998 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 199310011999 putative active site [active] 199310012000 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 199310012001 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 199310012002 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 199310012003 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 199310012004 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 199310012005 active site 199310012006 (T/H)XGH motif; other site 199310012007 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 199310012008 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 199310012009 DNA binding site [nucleotide binding] 199310012010 catalytic residue [active] 199310012011 H2TH interface [polypeptide binding]; other site 199310012012 putative catalytic residues [active] 199310012013 turnover-facilitating residue; other site 199310012014 intercalation triad [nucleotide binding]; other site 199310012015 8OG recognition residue [nucleotide binding]; other site 199310012016 putative reading head residues; other site 199310012017 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 199310012018 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 199310012019 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 199310012020 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 199310012021 hypothetical protein; Reviewed; Region: PRK00024 199310012022 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 199310012023 MPN+ (JAMM) motif; other site 199310012024 Zinc-binding site [ion binding]; other site 199310012025 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 199310012026 Flavoprotein; Region: Flavoprotein; pfam02441 199310012027 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 199310012028 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 199310012029 trimer interface [polypeptide binding]; other site 199310012030 active site 199310012031 division inhibitor protein; Provisional; Region: slmA; PRK09480 199310012032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310012033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 199310012034 active site 199310012035 ribonuclease PH; Reviewed; Region: rph; PRK00173 199310012036 Ribonuclease PH; Region: RNase_PH_bact; cd11362 199310012037 hexamer interface [polypeptide binding]; other site 199310012038 active site 199310012039 hypothetical protein; Provisional; Region: PRK11820 199310012040 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 199310012041 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 199310012042 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 199310012043 BRO family, N-terminal domain; Region: Bro-N; pfam02498 199310012044 Predicted membrane protein [Function unknown]; Region: COG2860 199310012045 UPF0126 domain; Region: UPF0126; pfam03458 199310012046 UPF0126 domain; Region: UPF0126; pfam03458 199310012047 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 199310012048 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 199310012049 nucleotide binding pocket [chemical binding]; other site 199310012050 K-X-D-G motif; other site 199310012051 catalytic site [active] 199310012052 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 199310012053 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 199310012054 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 199310012055 catalytic site [active] 199310012056 G-X2-G-X-G-K; other site 199310012057 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 199310012058 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 199310012059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 199310012060 Zn2+ binding site [ion binding]; other site 199310012061 Mg2+ binding site [ion binding]; other site 199310012062 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 199310012063 synthetase active site [active] 199310012064 NTP binding site [chemical binding]; other site 199310012065 metal binding site [ion binding]; metal-binding site 199310012066 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 199310012067 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 199310012068 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 199310012069 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 199310012070 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 199310012071 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 199310012072 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 199310012073 generic binding surface II; other site 199310012074 ssDNA binding site; other site 199310012075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310012076 ATP binding site [chemical binding]; other site 199310012077 putative Mg++ binding site [ion binding]; other site 199310012078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310012079 nucleotide binding region [chemical binding]; other site 199310012080 ATP-binding site [chemical binding]; other site 199310012081 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 199310012082 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 199310012083 AsmA family; Region: AsmA; pfam05170 199310012084 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 199310012085 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 199310012086 fructokinase; Reviewed; Region: PRK09557 199310012087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310012088 nucleotide binding site [chemical binding]; other site 199310012089 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 199310012090 intersubunit interface [polypeptide binding]; other site 199310012091 active site 199310012092 zinc binding site [ion binding]; other site 199310012093 Na+ binding site [ion binding]; other site 199310012094 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 199310012095 intersubunit interface [polypeptide binding]; other site 199310012096 active site 199310012097 zinc binding site [ion binding]; other site 199310012098 Na+ binding site [ion binding]; other site 199310012099 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 199310012100 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 199310012101 active site 199310012102 P-loop; other site 199310012103 phosphorylation site [posttranslational modification] 199310012104 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310012105 active site 199310012106 phosphorylation site [posttranslational modification] 199310012107 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 199310012108 HTH domain; Region: HTH_11; pfam08279 199310012109 Mga helix-turn-helix domain; Region: Mga; pfam05043 199310012110 PRD domain; Region: PRD; pfam00874 199310012111 PRD domain; Region: PRD; pfam00874 199310012112 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 199310012113 active site 199310012114 P-loop; other site 199310012115 phosphorylation site [posttranslational modification] 199310012116 putative alpha-glucosidase; Provisional; Region: PRK10658 199310012117 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 199310012118 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 199310012119 active site 199310012120 homotrimer interface [polypeptide binding]; other site 199310012121 catalytic site [active] 199310012122 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 199310012123 putative transporter; Provisional; Region: PRK11462 199310012124 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 199310012125 integrase; Provisional; Region: PRK09692 199310012126 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310012127 active site 199310012128 Int/Topo IB signature motif; other site 199310012129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 199310012130 TPR motif; other site 199310012131 binding surface 199310012132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 199310012133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310012134 DNA binding site [nucleotide binding] 199310012135 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 199310012136 ligand binding site [chemical binding]; other site 199310012137 dimerization interface [polypeptide binding]; other site 199310012138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012139 D-galactonate transporter; Region: 2A0114; TIGR00893 199310012140 putative substrate translocation pore; other site 199310012141 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 199310012142 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 199310012143 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 199310012144 putative active site [active] 199310012145 putative catalytic site [active] 199310012146 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 199310012147 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 199310012148 arginine decarboxylase; Provisional; Region: PRK15029 199310012149 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 199310012150 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 199310012151 homodimer interface [polypeptide binding]; other site 199310012152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310012153 catalytic residue [active] 199310012154 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 199310012155 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 199310012156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 199310012157 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 199310012158 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 199310012159 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 199310012160 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 199310012161 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 199310012162 Helix-turn-helix domain; Region: HTH_38; pfam13936 199310012163 Integrase core domain; Region: rve; pfam00665 199310012164 putative transposase OrfB; Reviewed; Region: PHA02517 199310012165 HTH-like domain; Region: HTH_21; pfam13276 199310012166 Integrase core domain; Region: rve; pfam00665 199310012167 Integrase core domain; Region: rve_2; pfam13333 199310012168 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 199310012169 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 199310012170 active site 199310012171 NTP binding site [chemical binding]; other site 199310012172 metal binding triad [ion binding]; metal-binding site 199310012173 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 199310012174 active site 199310012175 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 199310012176 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 199310012177 ImpA domain protein; Region: DUF3702; pfam12486 199310012178 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 199310012179 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 199310012180 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 199310012181 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 199310012182 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 199310012183 putative active site [active] 199310012184 metal binding site [ion binding]; metal-binding site 199310012185 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 199310012186 Propanediol utilisation protein PduL; Region: PduL; pfam06130 199310012187 Propanediol utilisation protein PduL; Region: PduL; pfam06130 199310012188 ethanolamine utilization protein EutJ family protein; Region: EutJ; TIGR02529 199310012189 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310012190 nucleotide binding site [chemical binding]; other site 199310012191 Flavoprotein; Region: Flavoprotein; cl08021 199310012192 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 199310012193 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 199310012194 Hexamer/Pentamer interface [polypeptide binding]; other site 199310012195 central pore; other site 199310012196 Domain of unknown function (DUF336); Region: DUF336; pfam03928 199310012197 propionate/acetate kinase; Provisional; Region: PRK12379 199310012198 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 199310012199 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 199310012200 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 199310012201 Hexamer interface [polypeptide binding]; other site 199310012202 Hexagonal pore residue; other site 199310012203 propanediol utilization protein PduB; Provisional; Region: PRK15415 199310012204 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 199310012205 putative hexamer interface [polypeptide binding]; other site 199310012206 putative hexagonal pore; other site 199310012207 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 199310012208 putative hexamer interface [polypeptide binding]; other site 199310012209 putative hexagonal pore; other site 199310012210 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 199310012211 putative catalytic cysteine [active] 199310012212 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 199310012213 putative hexamer interface [polypeptide binding]; other site 199310012214 putative hexagonal pore; other site 199310012215 intracellular protease, PfpI family; Region: PfpI; TIGR01382 199310012216 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 199310012217 conserved cys residue [active] 199310012218 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 199310012219 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 199310012220 dimer interface [polypeptide binding]; other site 199310012221 active site 199310012222 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 199310012223 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 199310012224 4Fe-4S binding domain; Region: Fer4; cl02805 199310012225 4Fe-4S binding domain; Region: Fer4_6; pfam12837 199310012226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310012227 FeS/SAM binding site; other site 199310012228 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 199310012229 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 199310012230 putative NTP binding site [chemical binding]; other site 199310012231 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 199310012232 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 199310012233 active site 199310012234 nucleic acid binding site [nucleotide binding]; other site 199310012235 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 199310012236 Sensory domain found in PocR; Region: PocR; pfam10114 199310012237 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 199310012238 Histidine kinase; Region: His_kinase; pfam06580 199310012239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310012240 ATP binding site [chemical binding]; other site 199310012241 Mg2+ binding site [ion binding]; other site 199310012242 G-X-G motif; other site 199310012243 Response regulator receiver domain; Region: Response_reg; pfam00072 199310012244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310012245 active site 199310012246 phosphorylation site [posttranslational modification] 199310012247 intermolecular recognition site; other site 199310012248 dimerization interface [polypeptide binding]; other site 199310012249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310012250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310012251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310012252 S-adenosylmethionine synthetase; Validated; Region: PRK05250 199310012253 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 199310012254 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 199310012255 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 199310012256 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 199310012257 Hexamer interface [polypeptide binding]; other site 199310012258 Hexagonal pore residue; other site 199310012259 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 199310012260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310012261 Protein export membrane protein; Region: SecD_SecF; cl14618 199310012262 Transposase; Region: HTH_Tnp_1; cl17663 199310012263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310012264 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 199310012265 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310012266 Predicted GTPase [General function prediction only]; Region: COG3596 199310012267 YfjP GTPase; Region: YfjP; cd11383 199310012268 G1 box; other site 199310012269 GTP/Mg2+ binding site [chemical binding]; other site 199310012270 Switch I region; other site 199310012271 G2 box; other site 199310012272 Switch II region; other site 199310012273 G3 box; other site 199310012274 G4 box; other site 199310012275 G5 box; other site 199310012276 HTH domain; Region: HTH_11; cl17392 199310012277 WYL domain; Region: WYL; pfam13280 199310012278 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 199310012279 Domain of unknown function (DUF932); Region: DUF932; pfam06067 199310012280 Antirestriction protein; Region: Antirestrict; pfam03230 199310012281 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 199310012282 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 199310012283 MPN+ (JAMM) motif; other site 199310012284 Zinc-binding site [ion binding]; other site 199310012285 Protein of unknown function (DUF987); Region: DUF987; pfam06174 199310012286 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 199310012287 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 199310012288 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 199310012289 Methyltransferase domain; Region: Methyltransf_27; pfam13708 199310012290 Virulence protein [General function prediction only]; Region: COG3943 199310012291 EamA-like transporter family; Region: EamA; pfam00892 199310012292 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 199310012293 EamA-like transporter family; Region: EamA; pfam00892 199310012294 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 199310012295 lipoprotein, YaeC family; Region: TIGR00363 199310012296 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 199310012297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012298 putative substrate translocation pore; other site 199310012299 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 199310012300 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 199310012301 cryptic adenine deaminase; Provisional; Region: PRK10027 199310012302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 199310012303 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 199310012304 active site 199310012305 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 199310012306 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 199310012307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012308 putative substrate translocation pore; other site 199310012309 regulatory protein UhpC; Provisional; Region: PRK11663 199310012310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012311 putative substrate translocation pore; other site 199310012312 sensory histidine kinase UhpB; Provisional; Region: PRK11644 199310012313 MASE1; Region: MASE1; pfam05231 199310012314 Histidine kinase; Region: HisKA_3; pfam07730 199310012315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310012316 ATP binding site [chemical binding]; other site 199310012317 Mg2+ binding site [ion binding]; other site 199310012318 G-X-G motif; other site 199310012319 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 199310012320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310012321 active site 199310012322 phosphorylation site [posttranslational modification] 199310012323 intermolecular recognition site; other site 199310012324 dimerization interface [polypeptide binding]; other site 199310012325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310012326 DNA binding residues [nucleotide binding] 199310012327 dimerization interface [polypeptide binding]; other site 199310012328 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 199310012329 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 199310012330 putative valine binding site [chemical binding]; other site 199310012331 dimer interface [polypeptide binding]; other site 199310012332 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 199310012333 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 199310012334 PYR/PP interface [polypeptide binding]; other site 199310012335 dimer interface [polypeptide binding]; other site 199310012336 TPP binding site [chemical binding]; other site 199310012337 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 199310012338 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 199310012339 TPP-binding site [chemical binding]; other site 199310012340 dimer interface [polypeptide binding]; other site 199310012341 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 199310012342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012343 putative substrate translocation pore; other site 199310012344 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 199310012345 Domain of unknown function (DUF202); Region: DUF202; pfam02656 199310012346 Predicted membrane protein [Function unknown]; Region: COG2149 199310012347 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 199310012348 Sulfatase; Region: Sulfatase; pfam00884 199310012349 putative transporter; Provisional; Region: PRK10484 199310012350 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 199310012351 Na binding site [ion binding]; other site 199310012352 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 199310012353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310012354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310012355 putative transporter; Validated; Region: PRK03818 199310012356 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 199310012357 TrkA-C domain; Region: TrkA_C; pfam02080 199310012358 TrkA-C domain; Region: TrkA_C; pfam02080 199310012359 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 199310012360 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 199310012361 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 199310012362 putative dimer interface [polypeptide binding]; other site 199310012363 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 199310012364 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 199310012365 putative dimer interface [polypeptide binding]; other site 199310012366 hypothetical protein; Provisional; Region: PRK11616 199310012367 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 199310012368 putative oxidoreductase; Provisional; Region: PRK11445 199310012369 hypothetical protein; Provisional; Region: PRK07236 199310012370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012371 D-galactonate transporter; Region: 2A0114; TIGR00893 199310012372 putative substrate translocation pore; other site 199310012373 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 199310012374 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 199310012375 Transcriptional regulators [Transcription]; Region: FadR; COG2186 199310012376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310012377 DNA-binding site [nucleotide binding]; DNA binding site 199310012378 FCD domain; Region: FCD; pfam07729 199310012379 hypothetical protein; Provisional; Region: PRK10215 199310012380 hypothetical protein; Provisional; Region: PRK10215 199310012381 sugar phosphate phosphatase; Provisional; Region: PRK10513 199310012382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310012383 active site 199310012384 motif I; other site 199310012385 motif II; other site 199310012386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310012387 hypothetical protein; Provisional; Region: PRK11426 199310012388 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 199310012389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310012390 Mg2+ binding site [ion binding]; other site 199310012391 G-X-G motif; other site 199310012392 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 199310012393 anchoring element; other site 199310012394 dimer interface [polypeptide binding]; other site 199310012395 ATP binding site [chemical binding]; other site 199310012396 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 199310012397 active site 199310012398 putative metal-binding site [ion binding]; other site 199310012399 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 199310012400 recF protein; Region: recf; TIGR00611 199310012401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310012402 Walker A/P-loop; other site 199310012403 ATP binding site [chemical binding]; other site 199310012404 Q-loop/lid; other site 199310012405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310012406 ABC transporter signature motif; other site 199310012407 Walker B; other site 199310012408 D-loop; other site 199310012409 H-loop/switch region; other site 199310012410 DNA polymerase III subunit beta; Validated; Region: PRK05643 199310012411 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 199310012412 putative DNA binding surface [nucleotide binding]; other site 199310012413 dimer interface [polypeptide binding]; other site 199310012414 beta-clamp/clamp loader binding surface; other site 199310012415 beta-clamp/translesion DNA polymerase binding surface; other site 199310012416 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 199310012417 ribonuclease P; Reviewed; Region: rnpA; PRK01732 199310012418 membrane protein insertase; Provisional; Region: PRK01318 199310012419 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 199310012420 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 199310012421 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 199310012422 trmE is a tRNA modification GTPase; Region: trmE; cd04164 199310012423 G1 box; other site 199310012424 GTP/Mg2+ binding site [chemical binding]; other site 199310012425 Switch I region; other site 199310012426 G2 box; other site 199310012427 Switch II region; other site 199310012428 G3 box; other site 199310012429 G4 box; other site 199310012430 G5 box; other site 199310012431 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 199310012432 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 199310012433 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 199310012434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 199310012435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 199310012436 catalytic residue [active] 199310012437 tryptophan permease TnaB; Provisional; Region: PRK09664 199310012438 aromatic amino acid transport protein; Region: araaP; TIGR00837 199310012439 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 199310012440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012441 putative substrate translocation pore; other site 199310012442 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 199310012443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310012444 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 199310012445 substrate binding pocket [chemical binding]; other site 199310012446 dimerization interface [polypeptide binding]; other site 199310012447 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 199310012448 Predicted flavoprotein [General function prediction only]; Region: COG0431 199310012449 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 199310012450 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 199310012451 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 199310012452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310012453 active site 199310012454 motif I; other site 199310012455 motif II; other site 199310012456 putative inner membrane protein; Provisional; Region: PRK09823 199310012457 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 199310012458 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 199310012459 active site 199310012460 trimer interface [polypeptide binding]; other site 199310012461 allosteric site; other site 199310012462 active site lid [active] 199310012463 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 199310012464 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 199310012465 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 199310012466 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 199310012467 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 199310012468 trimer interface; other site 199310012469 sugar binding site [chemical binding]; other site 199310012470 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 199310012471 beta-galactosidase; Region: BGL; TIGR03356 199310012472 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 199310012473 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310012474 active site turn [active] 199310012475 phosphorylation site [posttranslational modification] 199310012476 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 199310012477 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 199310012478 HPr interaction site; other site 199310012479 glycerol kinase (GK) interaction site [polypeptide binding]; other site 199310012480 active site 199310012481 phosphorylation site [posttranslational modification] 199310012482 transcriptional antiterminator BglG; Provisional; Region: PRK09772 199310012483 CAT RNA binding domain; Region: CAT_RBD; pfam03123 199310012484 PRD domain; Region: PRD; pfam00874 199310012485 PRD domain; Region: PRD; pfam00874 199310012486 transcriptional regulator PhoU; Provisional; Region: PRK11115 199310012487 PhoU domain; Region: PhoU; pfam01895 199310012488 PhoU domain; Region: PhoU; pfam01895 199310012489 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 199310012490 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 199310012491 Walker A/P-loop; other site 199310012492 ATP binding site [chemical binding]; other site 199310012493 Q-loop/lid; other site 199310012494 ABC transporter signature motif; other site 199310012495 Walker B; other site 199310012496 D-loop; other site 199310012497 H-loop/switch region; other site 199310012498 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 199310012499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310012500 dimer interface [polypeptide binding]; other site 199310012501 conserved gate region; other site 199310012502 putative PBP binding loops; other site 199310012503 ABC-ATPase subunit interface; other site 199310012504 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 199310012505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310012506 dimer interface [polypeptide binding]; other site 199310012507 conserved gate region; other site 199310012508 putative PBP binding loops; other site 199310012509 ABC-ATPase subunit interface; other site 199310012510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310012511 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 199310012512 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 199310012513 glutaminase active site [active] 199310012514 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 199310012515 dimer interface [polypeptide binding]; other site 199310012516 active site 199310012517 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 199310012518 dimer interface [polypeptide binding]; other site 199310012519 active site 199310012520 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 199310012521 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 199310012522 Substrate binding site; other site 199310012523 Mg++ binding site; other site 199310012524 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 199310012525 active site 199310012526 substrate binding site [chemical binding]; other site 199310012527 CoA binding site [chemical binding]; other site 199310012528 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 199310012529 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 199310012530 gamma subunit interface [polypeptide binding]; other site 199310012531 epsilon subunit interface [polypeptide binding]; other site 199310012532 LBP interface [polypeptide binding]; other site 199310012533 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 199310012534 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 199310012535 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 199310012536 alpha subunit interaction interface [polypeptide binding]; other site 199310012537 Walker A motif; other site 199310012538 ATP binding site [chemical binding]; other site 199310012539 Walker B motif; other site 199310012540 inhibitor binding site; inhibition site 199310012541 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 199310012542 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 199310012543 core domain interface [polypeptide binding]; other site 199310012544 delta subunit interface [polypeptide binding]; other site 199310012545 epsilon subunit interface [polypeptide binding]; other site 199310012546 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 199310012547 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 199310012548 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 199310012549 beta subunit interaction interface [polypeptide binding]; other site 199310012550 Walker A motif; other site 199310012551 ATP binding site [chemical binding]; other site 199310012552 Walker B motif; other site 199310012553 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 199310012554 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 199310012555 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 199310012556 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 199310012557 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 199310012558 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 199310012559 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 199310012560 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 199310012561 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 199310012562 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 199310012563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310012564 S-adenosylmethionine binding site [chemical binding]; other site 199310012565 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 199310012566 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 199310012567 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 199310012568 FMN-binding protein MioC; Provisional; Region: PRK09004 199310012569 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 199310012570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 199310012571 putative DNA binding site [nucleotide binding]; other site 199310012572 putative Zn2+ binding site [ion binding]; other site 199310012573 AsnC family; Region: AsnC_trans_reg; pfam01037 199310012574 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 199310012575 dimer interface [polypeptide binding]; other site 199310012576 active site 199310012577 hypothetical protein; Provisional; Region: yieM; PRK10997 199310012578 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 199310012579 metal ion-dependent adhesion site (MIDAS); other site 199310012580 regulatory ATPase RavA; Provisional; Region: PRK13531 199310012581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310012582 Walker A motif; other site 199310012583 ATP binding site [chemical binding]; other site 199310012584 Walker B motif; other site 199310012585 arginine finger; other site 199310012586 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 199310012587 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 199310012588 potassium uptake protein; Region: kup; TIGR00794 199310012589 D-ribose pyranase; Provisional; Region: PRK11797 199310012590 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 199310012591 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 199310012592 Walker A/P-loop; other site 199310012593 ATP binding site [chemical binding]; other site 199310012594 Q-loop/lid; other site 199310012595 ABC transporter signature motif; other site 199310012596 Walker B; other site 199310012597 D-loop; other site 199310012598 H-loop/switch region; other site 199310012599 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310012600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310012601 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310012602 TM-ABC transporter signature motif; other site 199310012603 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 199310012604 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 199310012605 ligand binding site [chemical binding]; other site 199310012606 dimerization interface [polypeptide binding]; other site 199310012607 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 199310012608 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310012609 substrate binding site [chemical binding]; other site 199310012610 dimer interface [polypeptide binding]; other site 199310012611 ATP binding site [chemical binding]; other site 199310012612 transcriptional repressor RbsR; Provisional; Region: PRK10423 199310012613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310012614 DNA binding site [nucleotide binding] 199310012615 domain linker motif; other site 199310012616 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 199310012617 dimerization interface [polypeptide binding]; other site 199310012618 ligand binding site [chemical binding]; other site 199310012619 putative transporter; Provisional; Region: PRK10504 199310012620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012621 putative substrate translocation pore; other site 199310012622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310012623 Transcriptional regulators [Transcription]; Region: FadR; COG2186 199310012624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310012625 DNA-binding site [nucleotide binding]; DNA binding site 199310012626 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310012627 transcriptional regulator HdfR; Provisional; Region: PRK03601 199310012628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310012629 LysR substrate binding domain; Region: LysR_substrate; pfam03466 199310012630 dimerization interface [polypeptide binding]; other site 199310012631 hypothetical protein; Provisional; Region: PRK11027 199310012632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310012633 Walker A motif; other site 199310012634 ATP binding site [chemical binding]; other site 199310012635 Walker B motif; other site 199310012636 arginine finger; other site 199310012637 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 199310012638 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 199310012639 ilvG operon leader peptide; Provisional; Region: PRK10424 199310012640 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 199310012641 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 199310012642 PYR/PP interface [polypeptide binding]; other site 199310012643 dimer interface [polypeptide binding]; other site 199310012644 TPP binding site [chemical binding]; other site 199310012645 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 199310012646 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 199310012647 TPP-binding site [chemical binding]; other site 199310012648 dimer interface [polypeptide binding]; other site 199310012649 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 199310012650 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 199310012651 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 199310012652 homodimer interface [polypeptide binding]; other site 199310012653 substrate-cofactor binding pocket; other site 199310012654 catalytic residue [active] 199310012655 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 199310012656 threonine dehydratase; Reviewed; Region: PRK09224 199310012657 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 199310012658 tetramer interface [polypeptide binding]; other site 199310012659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310012660 catalytic residue [active] 199310012661 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 199310012662 putative Ile/Val binding site [chemical binding]; other site 199310012663 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 199310012664 putative Ile/Val binding site [chemical binding]; other site 199310012665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310012666 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 199310012667 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 199310012668 putative dimerization interface [polypeptide binding]; other site 199310012669 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 199310012670 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 199310012671 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 199310012672 Part of AAA domain; Region: AAA_19; pfam13245 199310012673 Family description; Region: UvrD_C_2; pfam13538 199310012674 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 199310012675 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 199310012676 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 199310012677 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 199310012678 ATP binding site [chemical binding]; other site 199310012679 Mg++ binding site [ion binding]; other site 199310012680 motif III; other site 199310012681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310012682 nucleotide binding region [chemical binding]; other site 199310012683 ATP-binding site [chemical binding]; other site 199310012684 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 199310012685 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 199310012686 catalytic residues [active] 199310012687 putative rho operon leader peptide; Provisional; Region: PRK09979 199310012688 transcription termination factor Rho; Provisional; Region: rho; PRK09376 199310012689 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 199310012690 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 199310012691 RNA binding site [nucleotide binding]; other site 199310012692 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 199310012693 multimer interface [polypeptide binding]; other site 199310012694 Walker A motif; other site 199310012695 ATP binding site [chemical binding]; other site 199310012696 Walker B motif; other site 199310012697 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 199310012698 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 199310012699 Mg++ binding site [ion binding]; other site 199310012700 putative catalytic motif [active] 199310012701 substrate binding site [chemical binding]; other site 199310012702 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 199310012703 Chain length determinant protein; Region: Wzz; pfam02706 199310012704 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 199310012705 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 199310012706 active site 199310012707 homodimer interface [polypeptide binding]; other site 199310012708 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 199310012709 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 199310012710 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 199310012711 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 199310012712 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 199310012713 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 199310012714 NAD binding site [chemical binding]; other site 199310012715 substrate binding site [chemical binding]; other site 199310012716 homodimer interface [polypeptide binding]; other site 199310012717 active site 199310012718 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 199310012719 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 199310012720 substrate binding site; other site 199310012721 tetramer interface; other site 199310012722 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 199310012723 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 199310012724 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 199310012725 inhibitor-cofactor binding pocket; inhibition site 199310012726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310012727 catalytic residue [active] 199310012728 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 199310012729 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 199310012730 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 199310012731 putative common antigen polymerase; Provisional; Region: PRK02975 199310012732 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 199310012733 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 199310012734 putative transport protein YifK; Provisional; Region: PRK10746 199310012735 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 199310012736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310012737 FeS/SAM binding site; other site 199310012738 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 199310012739 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 199310012740 Sulfatase; Region: Sulfatase; pfam00884 199310012741 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 199310012742 HemY protein N-terminus; Region: HemY_N; pfam07219 199310012743 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 199310012744 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 199310012745 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 199310012746 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 199310012747 active site 199310012748 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 199310012749 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 199310012750 domain interfaces; other site 199310012751 active site 199310012752 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 199310012753 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 199310012754 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 199310012755 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 199310012756 putative iron binding site [ion binding]; other site 199310012757 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 199310012758 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 199310012759 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 199310012760 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 199310012761 hypothetical protein; Provisional; Region: PRK10963 199310012762 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 199310012763 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 199310012764 active site 199310012765 DNA binding site [nucleotide binding] 199310012766 Int/Topo IB signature motif; other site 199310012767 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 199310012768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310012769 motif II; other site 199310012770 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 199310012771 Part of AAA domain; Region: AAA_19; pfam13245 199310012772 Family description; Region: UvrD_C_2; pfam13538 199310012773 Uncharacterized conserved protein [Function unknown]; Region: COG1912 199310012774 Predicted periplasmic protein [Function unknown]; Region: COG3698 199310012775 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 199310012776 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 199310012777 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 199310012778 Cl binding site [ion binding]; other site 199310012779 oligomer interface [polypeptide binding]; other site 199310012780 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 199310012781 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 199310012782 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 199310012783 EamA-like transporter family; Region: EamA; cl17759 199310012784 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 199310012785 CoenzymeA binding site [chemical binding]; other site 199310012786 subunit interaction site [polypeptide binding]; other site 199310012787 PHB binding site; other site 199310012788 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 199310012789 dimerization interface [polypeptide binding]; other site 199310012790 substrate binding site [chemical binding]; other site 199310012791 active site 199310012792 calcium binding site [ion binding]; other site 199310012793 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 199310012794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310012795 ATP binding site [chemical binding]; other site 199310012796 putative Mg++ binding site [ion binding]; other site 199310012797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310012798 nucleotide binding region [chemical binding]; other site 199310012799 ATP-binding site [chemical binding]; other site 199310012800 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 199310012801 Helicase and RNase D C-terminal; Region: HRDC; smart00341 199310012802 threonine efflux system; Provisional; Region: PRK10229 199310012803 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 199310012804 lysophospholipase L2; Provisional; Region: PRK10749 199310012805 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 199310012806 putative hydrolase; Provisional; Region: PRK10976 199310012807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310012808 active site 199310012809 motif I; other site 199310012810 motif II; other site 199310012811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310012812 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 199310012813 EamA-like transporter family; Region: EamA; pfam00892 199310012814 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 199310012815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310012816 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 199310012817 putative dimerization interface [polypeptide binding]; other site 199310012818 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 199310012819 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 199310012820 THF binding site; other site 199310012821 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 199310012822 substrate binding site [chemical binding]; other site 199310012823 THF binding site; other site 199310012824 zinc-binding site [ion binding]; other site 199310012825 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 199310012826 tetramer interface [polypeptide binding]; other site 199310012827 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 199310012828 active site 199310012829 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 199310012830 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 199310012831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310012832 active site turn [active] 199310012833 phosphorylation site [posttranslational modification] 199310012834 transketolase; Reviewed; Region: PRK12753 199310012835 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 199310012836 TPP-binding site [chemical binding]; other site 199310012837 dimer interface [polypeptide binding]; other site 199310012838 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 199310012839 PYR/PP interface [polypeptide binding]; other site 199310012840 dimer interface [polypeptide binding]; other site 199310012841 TPP binding site [chemical binding]; other site 199310012842 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 199310012843 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 199310012844 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 199310012845 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 199310012846 putative active site [active] 199310012847 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 199310012848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310012849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 199310012850 dimerization interface [polypeptide binding]; other site 199310012851 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 199310012852 Na binding site [ion binding]; other site 199310012853 allophanate hydrolase; Provisional; Region: PRK08186 199310012854 carbamate kinase; Reviewed; Region: PRK12686 199310012855 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 199310012856 putative substrate binding site [chemical binding]; other site 199310012857 nucleotide binding site [chemical binding]; other site 199310012858 nucleotide binding site [chemical binding]; other site 199310012859 homodimer interface [polypeptide binding]; other site 199310012860 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 199310012861 CoA binding domain; Region: CoA_binding; pfam02629 199310012862 CoA-ligase; Region: Ligase_CoA; pfam00549 199310012863 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 199310012864 Isochorismatase family; Region: Isochorismatase; pfam00857 199310012865 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 199310012866 catalytic triad [active] 199310012867 conserved cis-peptide bond; other site 199310012868 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 199310012869 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 199310012870 uridine phosphorylase; Provisional; Region: PRK11178 199310012871 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 199310012872 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 199310012873 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 199310012874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 199310012875 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 199310012876 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 199310012877 active site 199310012878 intersubunit interface [polypeptide binding]; other site 199310012879 catalytic residue [active] 199310012880 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 199310012881 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 199310012882 Transcriptional regulator [Transcription]; Region: IclR; COG1414 199310012883 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 199310012884 Bacterial transcriptional regulator; Region: IclR; pfam01614 199310012885 DNA recombination protein RmuC; Provisional; Region: PRK10361 199310012886 RmuC family; Region: RmuC; pfam02646 199310012887 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 199310012888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310012889 S-adenosylmethionine binding site [chemical binding]; other site 199310012890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 199310012891 SCP-2 sterol transfer family; Region: SCP2; pfam02036 199310012892 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 199310012893 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 199310012894 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 199310012895 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 199310012896 sec-independent translocase; Provisional; Region: PRK01770 199310012897 sec-independent translocase; Provisional; Region: tatB; PRK00404 199310012898 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 199310012899 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 199310012900 active site 199310012901 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 199310012902 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 199310012903 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 199310012904 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 199310012905 FMN reductase; Validated; Region: fre; PRK08051 199310012906 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 199310012907 FAD binding pocket [chemical binding]; other site 199310012908 FAD binding motif [chemical binding]; other site 199310012909 phosphate binding motif [ion binding]; other site 199310012910 beta-alpha-beta structure motif; other site 199310012911 NAD binding pocket [chemical binding]; other site 199310012912 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 199310012913 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 199310012914 dimer interface [polypeptide binding]; other site 199310012915 active site 199310012916 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 199310012917 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 199310012918 substrate binding site [chemical binding]; other site 199310012919 oxyanion hole (OAH) forming residues; other site 199310012920 trimer interface [polypeptide binding]; other site 199310012921 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 199310012922 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 199310012923 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 199310012924 proline dipeptidase; Provisional; Region: PRK13607 199310012925 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 199310012926 active site 199310012927 hypothetical protein; Provisional; Region: PRK11568 199310012928 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 199310012929 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 199310012930 potassium transporter; Provisional; Region: PRK10750 199310012931 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 199310012932 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 199310012933 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 199310012934 Walker A motif; other site 199310012935 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 199310012936 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 199310012937 GTP binding site; other site 199310012938 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 199310012939 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 199310012940 serine/threonine protein kinase; Provisional; Region: PRK11768 199310012941 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 199310012942 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 199310012943 catalytic residues [active] 199310012944 hinge region; other site 199310012945 alpha helical domain; other site 199310012946 hypothetical protein; Provisional; Region: PRK11367 199310012947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 199310012948 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 199310012949 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 199310012950 putative acyl-acceptor binding pocket; other site 199310012951 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 199310012952 G1 box; other site 199310012953 GTP/Mg2+ binding site [chemical binding]; other site 199310012954 Switch I region; other site 199310012955 G2 box; other site 199310012956 G3 box; other site 199310012957 Switch II region; other site 199310012958 G4 box; other site 199310012959 G5 box; other site 199310012960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 199310012961 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 199310012962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310012963 FeS/SAM binding site; other site 199310012964 HemN C-terminal domain; Region: HemN_C; pfam06969 199310012965 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 199310012966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310012967 active site 199310012968 phosphorylation site [posttranslational modification] 199310012969 intermolecular recognition site; other site 199310012970 dimerization interface [polypeptide binding]; other site 199310012971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310012972 Walker A motif; other site 199310012973 ATP binding site [chemical binding]; other site 199310012974 Walker B motif; other site 199310012975 arginine finger; other site 199310012976 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310012977 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 199310012978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 199310012979 putative active site [active] 199310012980 heme pocket [chemical binding]; other site 199310012981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310012982 dimer interface [polypeptide binding]; other site 199310012983 phosphorylation site [posttranslational modification] 199310012984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310012985 ATP binding site [chemical binding]; other site 199310012986 Mg2+ binding site [ion binding]; other site 199310012987 G-X-G motif; other site 199310012988 glutamine synthetase; Provisional; Region: glnA; PRK09469 199310012989 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 199310012990 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 199310012991 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 199310012992 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 199310012993 G1 box; other site 199310012994 putative GEF interaction site [polypeptide binding]; other site 199310012995 GTP/Mg2+ binding site [chemical binding]; other site 199310012996 Switch I region; other site 199310012997 G2 box; other site 199310012998 G3 box; other site 199310012999 Switch II region; other site 199310013000 G4 box; other site 199310013001 G5 box; other site 199310013002 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 199310013003 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 199310013004 transcriptional regulator protein; Region: phnR; TIGR03337 199310013005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310013006 DNA-binding site [nucleotide binding]; DNA binding site 199310013007 UTRA domain; Region: UTRA; pfam07702 199310013008 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 199310013009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013010 putative substrate translocation pore; other site 199310013011 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 199310013012 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 199310013013 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 199310013014 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310013015 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 199310013016 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 199310013017 substrate binding site [chemical binding]; other site 199310013018 ATP binding site [chemical binding]; other site 199310013019 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 199310013020 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 199310013021 Class I aldolases; Region: Aldolase_Class_I; cl17187 199310013022 catalytic residue [active] 199310013023 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 199310013024 putative oxidoreductase; Provisional; Region: PRK10083 199310013025 NAD(P) binding site [chemical binding]; other site 199310013026 benzoate transport; Region: 2A0115; TIGR00895 199310013027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013029 shikimate transporter; Provisional; Region: PRK09952 199310013030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013031 putative substrate translocation pore; other site 199310013032 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 199310013033 active site 199310013034 catalytic residues [active] 199310013035 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 199310013036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310013037 motif II; other site 199310013038 hypothetical protein; Reviewed; Region: PRK01637 199310013039 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 199310013040 putative active site [active] 199310013041 dimerization interface [polypeptide binding]; other site 199310013042 putative tRNAtyr binding site [nucleotide binding]; other site 199310013043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310013044 Coenzyme A binding pocket [chemical binding]; other site 199310013045 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 199310013046 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 199310013047 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 199310013048 substrate binding pocket [chemical binding]; other site 199310013049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310013050 non-specific DNA binding site [nucleotide binding]; other site 199310013051 salt bridge; other site 199310013052 sequence-specific DNA binding site [nucleotide binding]; other site 199310013053 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 199310013054 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 199310013055 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 199310013056 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 199310013057 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 199310013058 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 199310013059 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 199310013060 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 199310013061 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 199310013062 [4Fe-4S] binding site [ion binding]; other site 199310013063 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 199310013064 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 199310013065 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 199310013066 molybdopterin cofactor binding site; other site 199310013067 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 199310013068 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 199310013069 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 199310013070 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 199310013071 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 199310013072 intersubunit interface [polypeptide binding]; other site 199310013073 active site 199310013074 Zn2+ binding site [ion binding]; other site 199310013075 L-rhamnose isomerase; Provisional; Region: PRK01076 199310013076 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 199310013077 N- and C-terminal domain interface [polypeptide binding]; other site 199310013078 active site 199310013079 putative catalytic site [active] 199310013080 metal binding site [ion binding]; metal-binding site 199310013081 ATP binding site [chemical binding]; other site 199310013082 rhamnulokinase; Provisional; Region: rhaB; PRK10640 199310013083 carbohydrate binding site [chemical binding]; other site 199310013084 transcriptional activator RhaS; Provisional; Region: PRK13503 199310013085 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 199310013086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013088 transcriptional activator RhaR; Provisional; Region: PRK13500 199310013089 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 199310013090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013092 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 199310013093 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 199310013094 superoxide dismutase; Provisional; Region: PRK10925 199310013095 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 199310013096 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 199310013097 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 199310013098 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 199310013099 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 199310013100 MOSC domain; Region: MOSC; pfam03473 199310013101 3-alpha domain; Region: 3-alpha; pfam03475 199310013102 two-component sensor protein; Provisional; Region: cpxA; PRK09470 199310013103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310013104 dimerization interface [polypeptide binding]; other site 199310013105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310013106 dimer interface [polypeptide binding]; other site 199310013107 phosphorylation site [posttranslational modification] 199310013108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310013109 ATP binding site [chemical binding]; other site 199310013110 Mg2+ binding site [ion binding]; other site 199310013111 G-X-G motif; other site 199310013112 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 199310013113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310013114 active site 199310013115 intermolecular recognition site; other site 199310013116 dimerization interface [polypeptide binding]; other site 199310013117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310013118 DNA binding site [nucleotide binding] 199310013119 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 199310013120 dimer interface [polypeptide binding]; other site 199310013121 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 199310013122 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 199310013123 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 199310013124 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 199310013125 active site 199310013126 ADP/pyrophosphate binding site [chemical binding]; other site 199310013127 dimerization interface [polypeptide binding]; other site 199310013128 allosteric effector site; other site 199310013129 fructose-1,6-bisphosphate binding site; other site 199310013130 sulfate transporter subunit; Provisional; Region: PRK10752 199310013131 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 199310013132 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 199310013133 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 199310013134 triosephosphate isomerase; Provisional; Region: PRK14567 199310013135 substrate binding site [chemical binding]; other site 199310013136 dimer interface [polypeptide binding]; other site 199310013137 catalytic triad [active] 199310013138 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 199310013139 Predicted membrane protein [Function unknown]; Region: COG3152 199310013140 hypothetical protein; Provisional; Region: PRK09981 199310013141 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 199310013142 Ligand Binding Site [chemical binding]; other site 199310013143 ferredoxin-NADP reductase; Provisional; Region: PRK10926 199310013144 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 199310013145 FAD binding pocket [chemical binding]; other site 199310013146 FAD binding motif [chemical binding]; other site 199310013147 phosphate binding motif [ion binding]; other site 199310013148 beta-alpha-beta structure motif; other site 199310013149 NAD binding pocket [chemical binding]; other site 199310013150 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 199310013151 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 199310013152 putative active site [active] 199310013153 glycerol kinase; Provisional; Region: glpK; PRK00047 199310013154 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 199310013155 N- and C-terminal domain interface [polypeptide binding]; other site 199310013156 active site 199310013157 MgATP binding site [chemical binding]; other site 199310013158 catalytic site [active] 199310013159 metal binding site [ion binding]; metal-binding site 199310013160 glycerol binding site [chemical binding]; other site 199310013161 homotetramer interface [polypeptide binding]; other site 199310013162 homodimer interface [polypeptide binding]; other site 199310013163 FBP binding site [chemical binding]; other site 199310013164 protein IIAGlc interface [polypeptide binding]; other site 199310013165 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 199310013166 amphipathic channel; other site 199310013167 Asn-Pro-Ala signature motifs; other site 199310013168 septal ring assembly protein ZapB; Provisional; Region: PRK15422 199310013169 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 199310013170 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 199310013171 UbiA prenyltransferase family; Region: UbiA; pfam01040 199310013172 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 199310013173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310013174 Walker A motif; other site 199310013175 ATP binding site [chemical binding]; other site 199310013176 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 199310013177 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 199310013178 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 199310013179 active site 199310013180 HslU subunit interaction site [polypeptide binding]; other site 199310013181 essential cell division protein FtsN; Provisional; Region: PRK10927 199310013182 cell division protein FtsN; Provisional; Region: PRK12757 199310013183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310013184 DNA binding site [nucleotide binding] 199310013185 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 199310013186 domain linker motif; other site 199310013187 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 199310013188 dimerization interface [polypeptide binding]; other site 199310013189 ligand binding site [chemical binding]; other site 199310013190 primosome assembly protein PriA; Validated; Region: PRK05580 199310013191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310013192 ATP binding site [chemical binding]; other site 199310013193 putative Mg++ binding site [ion binding]; other site 199310013194 helicase superfamily c-terminal domain; Region: HELICc; smart00490 199310013195 ATP-binding site [chemical binding]; other site 199310013196 hypothetical protein; Provisional; Region: PRK10030 199310013197 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 199310013198 dimerization interface [polypeptide binding]; other site 199310013199 DNA binding site [nucleotide binding] 199310013200 corepressor binding sites; other site 199310013201 cystathionine gamma-synthase; Provisional; Region: PRK08045 199310013202 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 199310013203 homodimer interface [polypeptide binding]; other site 199310013204 substrate-cofactor binding pocket; other site 199310013205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310013206 catalytic residue [active] 199310013207 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 199310013208 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 199310013209 putative catalytic residues [active] 199310013210 putative nucleotide binding site [chemical binding]; other site 199310013211 putative aspartate binding site [chemical binding]; other site 199310013212 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 199310013213 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 199310013214 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 199310013215 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 199310013216 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 199310013217 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 199310013218 active site 199310013219 metal binding site [ion binding]; metal-binding site 199310013220 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 199310013221 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 199310013222 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 199310013223 active site 199310013224 metal binding site [ion binding]; metal-binding site 199310013225 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 199310013226 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 199310013227 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 199310013228 active site 199310013229 metal binding site [ion binding]; metal-binding site 199310013230 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 199310013231 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 199310013232 FAD binding site [chemical binding]; other site 199310013233 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 199310013234 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 199310013235 heme binding site [chemical binding]; other site 199310013236 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 199310013237 EamA-like transporter family; Region: EamA; pfam00892 199310013238 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 199310013239 EamA-like transporter family; Region: EamA; pfam00892 199310013240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 199310013241 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 199310013242 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 199310013243 dimer interface [polypeptide binding]; other site 199310013244 active site 199310013245 metal binding site [ion binding]; metal-binding site 199310013246 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 199310013247 active site 199310013248 intersubunit interactions; other site 199310013249 catalytic residue [active] 199310013250 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 199310013251 dimerization domain swap beta strand [polypeptide binding]; other site 199310013252 regulatory protein interface [polypeptide binding]; other site 199310013253 active site 199310013254 regulatory phosphorylation site [posttranslational modification]; other site 199310013255 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 199310013256 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 199310013257 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 199310013258 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 199310013259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310013260 active site 199310013261 phosphorylation site [posttranslational modification] 199310013262 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 199310013263 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 199310013264 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 199310013265 active site 199310013266 P-loop; other site 199310013267 phosphorylation site [posttranslational modification] 199310013268 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 199310013269 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 199310013270 dimer interface [polypeptide binding]; other site 199310013271 active site 199310013272 glycine loop; other site 199310013273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 199310013274 FeS/SAM binding site; other site 199310013275 pyruvate formate lyase II activase; Provisional; Region: PRK10076 199310013276 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 199310013277 active site 199310013278 P-loop; other site 199310013279 phosphorylation site [posttranslational modification] 199310013280 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310013281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013282 hypothetical protein; Provisional; Region: PRK10649 199310013283 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 199310013284 Sulfatase; Region: Sulfatase; pfam00884 199310013285 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 199310013286 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 199310013287 acetylornithine deacetylase; Provisional; Region: PRK05111 199310013288 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 199310013289 metal binding site [ion binding]; metal-binding site 199310013290 putative dimer interface [polypeptide binding]; other site 199310013291 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 199310013292 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 199310013293 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 199310013294 nucleotide binding site [chemical binding]; other site 199310013295 N-acetyl-L-glutamate binding site [chemical binding]; other site 199310013296 argininosuccinate lyase; Provisional; Region: PRK04833 199310013297 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 199310013298 active sites [active] 199310013299 tetramer interface [polypeptide binding]; other site 199310013300 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 199310013301 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 199310013302 putative active site pocket [active] 199310013303 putative metal binding site [ion binding]; other site 199310013304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013305 D-galactonate transporter; Region: 2A0114; TIGR00893 199310013306 putative substrate translocation pore; other site 199310013307 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 199310013308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310013309 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 199310013310 dimerization interface [polypeptide binding]; other site 199310013311 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 199310013312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310013313 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 199310013314 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 199310013315 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 199310013316 metal binding site [ion binding]; metal-binding site 199310013317 putative dimer interface [polypeptide binding]; other site 199310013318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013319 metabolite-proton symporter; Region: 2A0106; TIGR00883 199310013320 putative substrate translocation pore; other site 199310013321 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 199310013322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310013323 hypothetical protein; Provisional; Region: PRK11056 199310013324 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 199310013325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310013326 S-adenosylmethionine binding site [chemical binding]; other site 199310013327 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 199310013328 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310013329 N-terminal plug; other site 199310013330 ligand-binding site [chemical binding]; other site 199310013331 glutamate racemase; Provisional; Region: PRK00865 199310013332 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 199310013333 FAD binding domain; Region: FAD_binding_4; pfam01565 199310013334 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 199310013335 Biotin operon repressor [Transcription]; Region: BirA; COG1654 199310013336 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 199310013337 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 199310013338 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 199310013339 pantothenate kinase; Provisional; Region: PRK05439 199310013340 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 199310013341 ATP-binding site [chemical binding]; other site 199310013342 CoA-binding site [chemical binding]; other site 199310013343 Mg2+-binding site [ion binding]; other site 199310013344 elongation factor Tu; Reviewed; Region: PRK00049 199310013345 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 199310013346 G1 box; other site 199310013347 GEF interaction site [polypeptide binding]; other site 199310013348 GTP/Mg2+ binding site [chemical binding]; other site 199310013349 Switch I region; other site 199310013350 G2 box; other site 199310013351 G3 box; other site 199310013352 Switch II region; other site 199310013353 G4 box; other site 199310013354 G5 box; other site 199310013355 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 199310013356 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 199310013357 Antibiotic Binding Site [chemical binding]; other site 199310013358 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 199310013359 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 199310013360 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 199310013361 putative homodimer interface [polypeptide binding]; other site 199310013362 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 199310013363 heterodimer interface [polypeptide binding]; other site 199310013364 homodimer interface [polypeptide binding]; other site 199310013365 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 199310013366 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 199310013367 23S rRNA interface [nucleotide binding]; other site 199310013368 L7/L12 interface [polypeptide binding]; other site 199310013369 putative thiostrepton binding site; other site 199310013370 L25 interface [polypeptide binding]; other site 199310013371 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 199310013372 mRNA/rRNA interface [nucleotide binding]; other site 199310013373 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 199310013374 23S rRNA interface [nucleotide binding]; other site 199310013375 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 199310013376 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 199310013377 core dimer interface [polypeptide binding]; other site 199310013378 peripheral dimer interface [polypeptide binding]; other site 199310013379 L10 interface [polypeptide binding]; other site 199310013380 L11 interface [polypeptide binding]; other site 199310013381 putative EF-Tu interaction site [polypeptide binding]; other site 199310013382 putative EF-G interaction site [polypeptide binding]; other site 199310013383 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 199310013384 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 199310013385 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 199310013386 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 199310013387 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 199310013388 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 199310013389 RPB3 interaction site [polypeptide binding]; other site 199310013390 RPB1 interaction site [polypeptide binding]; other site 199310013391 RPB11 interaction site [polypeptide binding]; other site 199310013392 RPB10 interaction site [polypeptide binding]; other site 199310013393 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 199310013394 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 199310013395 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 199310013396 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 199310013397 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 199310013398 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 199310013399 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 199310013400 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 199310013401 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 199310013402 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 199310013403 DNA binding site [nucleotide binding] 199310013404 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 199310013405 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 199310013406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310013407 FeS/SAM binding site; other site 199310013408 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 199310013409 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 199310013410 ThiS interaction site; other site 199310013411 putative active site [active] 199310013412 tetramer interface [polypeptide binding]; other site 199310013413 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 199310013414 thiS-thiF/thiG interaction site; other site 199310013415 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 199310013416 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 199310013417 ATP binding site [chemical binding]; other site 199310013418 substrate interface [chemical binding]; other site 199310013419 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 199310013420 thiamine phosphate binding site [chemical binding]; other site 199310013421 active site 199310013422 pyrophosphate binding site [ion binding]; other site 199310013423 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 199310013424 ThiC-associated domain; Region: ThiC-associated; pfam13667 199310013425 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 199310013426 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 199310013427 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 199310013428 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 199310013429 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 199310013430 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 199310013431 putative NADH binding site [chemical binding]; other site 199310013432 putative active site [active] 199310013433 nudix motif; other site 199310013434 putative metal binding site [ion binding]; other site 199310013435 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 199310013436 substrate binding site [chemical binding]; other site 199310013437 active site 199310013438 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 199310013439 Active_site [active] 199310013440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 199310013441 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 199310013442 IHF dimer interface [polypeptide binding]; other site 199310013443 IHF - DNA interface [nucleotide binding]; other site 199310013444 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 199310013445 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 199310013446 dimer interface [polypeptide binding]; other site 199310013447 sensor protein ZraS; Provisional; Region: PRK10364 199310013448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310013449 dimer interface [polypeptide binding]; other site 199310013450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310013451 ATP binding site [chemical binding]; other site 199310013452 Mg2+ binding site [ion binding]; other site 199310013453 G-X-G motif; other site 199310013454 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 199310013455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310013456 active site 199310013457 phosphorylation site [posttranslational modification] 199310013458 intermolecular recognition site; other site 199310013459 dimerization interface [polypeptide binding]; other site 199310013460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310013461 Walker A motif; other site 199310013462 ATP binding site [chemical binding]; other site 199310013463 Walker B motif; other site 199310013464 arginine finger; other site 199310013465 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310013466 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 199310013467 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 199310013468 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 199310013469 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 199310013470 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 199310013471 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 199310013472 purine monophosphate binding site [chemical binding]; other site 199310013473 dimer interface [polypeptide binding]; other site 199310013474 putative catalytic residues [active] 199310013475 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 199310013476 hypothetical protein; Provisional; Region: PRK10039 199310013477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 199310013478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310013479 Coenzyme A binding pocket [chemical binding]; other site 199310013480 homoserine O-succinyltransferase; Provisional; Region: PRK05368 199310013481 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 199310013482 proposed active site lysine [active] 199310013483 conserved cys residue [active] 199310013484 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 199310013485 malate synthase A; Region: malate_syn_A; TIGR01344 199310013486 active site 199310013487 isocitrate lyase; Provisional; Region: PRK15063 199310013488 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 199310013489 tetramer interface [polypeptide binding]; other site 199310013490 active site 199310013491 Mg2+/Mn2+ binding site [ion binding]; other site 199310013492 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 199310013493 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 199310013494 transcriptional repressor IclR; Provisional; Region: PRK11569 199310013495 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 199310013496 Bacterial transcriptional regulator; Region: IclR; pfam01614 199310013497 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 199310013498 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 199310013499 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 199310013500 substrate binding pocket [chemical binding]; other site 199310013501 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 199310013502 B12 binding site [chemical binding]; other site 199310013503 cobalt ligand [ion binding]; other site 199310013504 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 199310013505 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 199310013506 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 199310013507 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 199310013508 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 199310013509 active site pocket [active] 199310013510 oxyanion hole [active] 199310013511 catalytic triad [active] 199310013512 active site nucleophile [active] 199310013513 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 199310013514 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310013515 putative NAD(P) binding site [chemical binding]; other site 199310013516 catalytic Zn binding site [ion binding]; other site 199310013517 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 199310013518 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 199310013519 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 199310013520 active site 199310013521 phosphorylation site [posttranslational modification] 199310013522 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 199310013523 active pocket/dimerization site; other site 199310013524 active site 199310013525 phosphorylation site [posttranslational modification] 199310013526 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 199310013527 classical (c) SDRs; Region: SDR_c; cd05233 199310013528 NAD(P) binding site [chemical binding]; other site 199310013529 active site 199310013530 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 199310013531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 199310013532 putative DNA binding site [nucleotide binding]; other site 199310013533 putative Zn2+ binding site [ion binding]; other site 199310013534 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 199310013535 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 199310013536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 199310013537 RNA binding surface [nucleotide binding]; other site 199310013538 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 199310013539 probable active site [active] 199310013540 hypothetical protein; Provisional; Region: PRK10515 199310013541 aspartate kinase III; Validated; Region: PRK09084 199310013542 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 199310013543 nucleotide binding site [chemical binding]; other site 199310013544 substrate binding site [chemical binding]; other site 199310013545 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 199310013546 lysine allosteric regulatory site; other site 199310013547 dimer interface [polypeptide binding]; other site 199310013548 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 199310013549 dimer interface [polypeptide binding]; other site 199310013550 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 199310013551 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 199310013552 active site 199310013553 dimer interface [polypeptide binding]; other site 199310013554 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 199310013555 dimer interface [polypeptide binding]; other site 199310013556 active site 199310013557 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 199310013558 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 199310013559 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 199310013560 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 199310013561 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 199310013562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 199310013563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310013564 dimer interface [polypeptide binding]; other site 199310013565 conserved gate region; other site 199310013566 putative PBP binding loops; other site 199310013567 ABC-ATPase subunit interface; other site 199310013568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310013569 dimer interface [polypeptide binding]; other site 199310013570 conserved gate region; other site 199310013571 putative PBP binding loops; other site 199310013572 ABC-ATPase subunit interface; other site 199310013573 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 199310013574 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 199310013575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 199310013576 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 199310013577 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 199310013578 Walker A/P-loop; other site 199310013579 ATP binding site [chemical binding]; other site 199310013580 Q-loop/lid; other site 199310013581 ABC transporter signature motif; other site 199310013582 Walker B; other site 199310013583 D-loop; other site 199310013584 H-loop/switch region; other site 199310013585 TOBE domain; Region: TOBE_2; pfam08402 199310013586 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 199310013587 trimer interface; other site 199310013588 sugar binding site [chemical binding]; other site 199310013589 maltose regulon periplasmic protein; Provisional; Region: PRK10564 199310013590 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 199310013591 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 199310013592 UbiA prenyltransferase family; Region: UbiA; pfam01040 199310013593 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 199310013594 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 199310013595 putative acyl-acceptor binding pocket; other site 199310013596 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 199310013597 LexA repressor; Validated; Region: PRK00215 199310013598 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 199310013599 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 199310013600 Catalytic site [active] 199310013601 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 199310013602 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 199310013603 hypothetical protein; Provisional; Region: PRK10428 199310013604 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 199310013605 metal binding site 2 [ion binding]; metal-binding site 199310013606 putative DNA binding helix; other site 199310013607 metal binding site 1 [ion binding]; metal-binding site 199310013608 dimer interface [polypeptide binding]; other site 199310013609 structural Zn2+ binding site [ion binding]; other site 199310013610 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 199310013611 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 199310013612 FMN binding site [chemical binding]; other site 199310013613 active site 199310013614 catalytic residues [active] 199310013615 substrate binding site [chemical binding]; other site 199310013616 phage shock protein G; Reviewed; Region: pspG; PRK09459 199310013617 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 199310013618 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 199310013619 NADP binding site [chemical binding]; other site 199310013620 dimer interface [polypeptide binding]; other site 199310013621 L-aspartate oxidase; Provisional; Region: PRK06175 199310013622 FAD binding domain; Region: FAD_binding_2; pfam00890 199310013623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013624 metabolite-proton symporter; Region: 2A0106; TIGR00883 199310013625 putative substrate translocation pore; other site 199310013626 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 199310013627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 199310013628 substrate binding site [chemical binding]; other site 199310013629 oxyanion hole (OAH) forming residues; other site 199310013630 trimer interface [polypeptide binding]; other site 199310013631 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 199310013632 Coenzyme A transferase; Region: CoA_trans; smart00882 199310013633 Coenzyme A transferase; Region: CoA_trans; cl17247 199310013634 Transcriptional regulators [Transcription]; Region: PurR; COG1609 199310013635 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310013636 DNA binding site [nucleotide binding] 199310013637 domain linker motif; other site 199310013638 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 199310013639 putative dimerization interface [polypeptide binding]; other site 199310013640 putative ligand binding site [chemical binding]; other site 199310013641 replicative DNA helicase; Provisional; Region: PRK08006 199310013642 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 199310013643 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 199310013644 Walker A motif; other site 199310013645 ATP binding site [chemical binding]; other site 199310013646 Walker B motif; other site 199310013647 DNA binding loops [nucleotide binding] 199310013648 putative lipoprotein; Provisional; Region: PRK10533 199310013649 alanine racemase; Reviewed; Region: alr; PRK00053 199310013650 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 199310013651 active site 199310013652 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 199310013653 substrate binding site [chemical binding]; other site 199310013654 catalytic residues [active] 199310013655 dimer interface [polypeptide binding]; other site 199310013656 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 199310013657 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 199310013658 active site 199310013659 (T/H)XGH motif; other site 199310013660 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 199310013661 AAA domain; Region: AAA_28; pfam13521 199310013662 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 199310013663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 199310013664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310013665 homodimer interface [polypeptide binding]; other site 199310013666 catalytic residue [active] 199310013667 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 199310013668 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 199310013669 TPP-binding site [chemical binding]; other site 199310013670 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 199310013671 dimer interface [polypeptide binding]; other site 199310013672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 199310013673 E3 interaction surface; other site 199310013674 lipoyl attachment site [posttranslational modification]; other site 199310013675 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 199310013676 e3 binding domain; Region: E3_binding; pfam02817 199310013677 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 199310013678 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 199310013679 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 199310013680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 199310013681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 199310013682 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 199310013683 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 199310013684 CoA-ligase; Region: Ligase_CoA; pfam00549 199310013685 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 199310013686 CoA binding domain; Region: CoA_binding; smart00881 199310013687 CoA-ligase; Region: Ligase_CoA; pfam00549 199310013688 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 199310013689 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 199310013690 transmembrane helices; other site 199310013691 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 199310013692 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 199310013693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310013694 active site 199310013695 phosphorylation site [posttranslational modification] 199310013696 intermolecular recognition site; other site 199310013697 dimerization interface [polypeptide binding]; other site 199310013698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310013699 Walker A motif; other site 199310013700 ATP binding site [chemical binding]; other site 199310013701 Walker B motif; other site 199310013702 arginine finger; other site 199310013703 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310013704 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 199310013705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310013706 dimer interface [polypeptide binding]; other site 199310013707 phosphorylation site [posttranslational modification] 199310013708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310013709 ATP binding site [chemical binding]; other site 199310013710 Mg2+ binding site [ion binding]; other site 199310013711 G-X-G motif; other site 199310013712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310013713 active site 199310013714 motif I; other site 199310013715 motif II; other site 199310013716 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 199310013717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 199310013718 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 199310013719 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 199310013720 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 199310013721 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 199310013722 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 199310013723 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 199310013724 dimer interface [polypeptide binding]; other site 199310013725 ssDNA binding site [nucleotide binding]; other site 199310013726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 199310013727 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 199310013728 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 199310013729 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 199310013730 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 199310013731 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 199310013732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013733 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 199310013734 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 199310013735 DNA binding residues [nucleotide binding] 199310013736 dimer interface [polypeptide binding]; other site 199310013737 [2Fe-2S] cluster binding site [ion binding]; other site 199310013738 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 199310013739 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 199310013740 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 199310013741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 199310013742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310013743 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 199310013744 putative dimerization interface [polypeptide binding]; other site 199310013745 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 199310013746 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 199310013747 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 199310013748 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 199310013749 Na binding site [ion binding]; other site 199310013750 Predicted membrane protein [Function unknown]; Region: COG3162 199310013751 acetyl-CoA synthetase; Provisional; Region: PRK00174 199310013752 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 199310013753 active site 199310013754 CoA binding site [chemical binding]; other site 199310013755 acyl-activating enzyme (AAE) consensus motif; other site 199310013756 AMP binding site [chemical binding]; other site 199310013757 acetate binding site [chemical binding]; other site 199310013758 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 199310013759 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 199310013760 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 199310013761 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 199310013762 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 199310013763 heme lyase subunit NrfE; Provisional; Region: PRK10369 199310013764 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 199310013765 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 199310013766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 199310013767 binding surface 199310013768 TPR motif; other site 199310013769 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 199310013770 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 199310013771 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 199310013772 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 199310013773 Sel1-like repeats; Region: SEL1; smart00671 199310013774 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 199310013775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310013776 Walker A/P-loop; other site 199310013777 ATP binding site [chemical binding]; other site 199310013778 Q-loop/lid; other site 199310013779 ABC transporter signature motif; other site 199310013780 Walker B; other site 199310013781 D-loop; other site 199310013782 H-loop/switch region; other site 199310013783 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 199310013784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310013785 Walker A/P-loop; other site 199310013786 ATP binding site [chemical binding]; other site 199310013787 Q-loop/lid; other site 199310013788 ABC transporter signature motif; other site 199310013789 Walker B; other site 199310013790 D-loop; other site 199310013791 H-loop/switch region; other site 199310013792 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 199310013793 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 199310013794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310013795 dimer interface [polypeptide binding]; other site 199310013796 conserved gate region; other site 199310013797 ABC-ATPase subunit interface; other site 199310013798 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 199310013799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310013800 dimer interface [polypeptide binding]; other site 199310013801 conserved gate region; other site 199310013802 putative PBP binding loops; other site 199310013803 ABC-ATPase subunit interface; other site 199310013804 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 199310013805 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 199310013806 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 199310013807 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 199310013808 [4Fe-4S] binding site [ion binding]; other site 199310013809 molybdopterin cofactor binding site; other site 199310013810 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 199310013811 molybdopterin cofactor binding site; other site 199310013812 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 199310013813 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 199310013814 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 199310013815 multidrug resistance protein MdtN; Provisional; Region: PRK10476 199310013816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 199310013817 HlyD family secretion protein; Region: HlyD_3; pfam13437 199310013818 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 199310013819 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 199310013820 D-allose kinase; Provisional; Region: PRK09698 199310013821 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 199310013822 nucleotide binding site [chemical binding]; other site 199310013823 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 199310013824 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 199310013825 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 199310013826 substrate binding site [chemical binding]; other site 199310013827 hexamer interface [polypeptide binding]; other site 199310013828 metal binding site [ion binding]; metal-binding site 199310013829 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310013830 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310013831 TM-ABC transporter signature motif; other site 199310013832 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 199310013833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310013834 Walker A/P-loop; other site 199310013835 ATP binding site [chemical binding]; other site 199310013836 Q-loop/lid; other site 199310013837 ABC transporter signature motif; other site 199310013838 Walker B; other site 199310013839 D-loop; other site 199310013840 H-loop/switch region; other site 199310013841 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310013842 D-allose transporter subunit; Provisional; Region: PRK09701 199310013843 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 199310013844 ligand binding site [chemical binding]; other site 199310013845 dimerization interface [polypeptide binding]; other site 199310013846 zinc binding site [ion binding]; other site 199310013847 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 199310013848 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 199310013849 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 199310013850 putative active site [active] 199310013851 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 199310013852 putative hydrolase; Provisional; Region: PRK02113 199310013853 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 199310013854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310013855 Coenzyme A binding pocket [chemical binding]; other site 199310013856 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 199310013857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 199310013858 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 199310013859 active site 199310013860 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 199310013861 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 199310013862 Walker A/P-loop; other site 199310013863 ATP binding site [chemical binding]; other site 199310013864 Q-loop/lid; other site 199310013865 ABC transporter signature motif; other site 199310013866 Walker B; other site 199310013867 D-loop; other site 199310013868 H-loop/switch region; other site 199310013869 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 199310013870 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 199310013871 Walker A/P-loop; other site 199310013872 ATP binding site [chemical binding]; other site 199310013873 Q-loop/lid; other site 199310013874 ABC transporter signature motif; other site 199310013875 Walker B; other site 199310013876 D-loop; other site 199310013877 H-loop/switch region; other site 199310013878 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 199310013879 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 199310013880 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 199310013881 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 199310013882 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 199310013883 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 199310013884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310013885 DNA-binding site [nucleotide binding]; DNA binding site 199310013886 UTRA domain; Region: UTRA; pfam07702 199310013887 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 199310013888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 199310013889 dimer interface [polypeptide binding]; other site 199310013890 conserved gate region; other site 199310013891 putative PBP binding loops; other site 199310013892 ABC-ATPase subunit interface; other site 199310013893 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 199310013894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 199310013895 substrate binding pocket [chemical binding]; other site 199310013896 membrane-bound complex binding site; other site 199310013897 hinge residues; other site 199310013898 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 199310013899 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 199310013900 Walker A/P-loop; other site 199310013901 ATP binding site [chemical binding]; other site 199310013902 Q-loop/lid; other site 199310013903 ABC transporter signature motif; other site 199310013904 Walker B; other site 199310013905 D-loop; other site 199310013906 H-loop/switch region; other site 199310013907 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 199310013908 dimer interface [polypeptide binding]; other site 199310013909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 199310013910 hypothetical protein; Provisional; Region: PRK10220 199310013911 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 199310013912 PhnA protein; Region: PhnA; pfam03831 199310013913 hypothetical protein; Provisional; Region: PRK09866 199310013914 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 199310013915 G1 box; other site 199310013916 GTP/Mg2+ binding site [chemical binding]; other site 199310013917 G2 box; other site 199310013918 Switch I region; other site 199310013919 G3 box; other site 199310013920 Switch II region; other site 199310013921 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 199310013922 G2 box; other site 199310013923 Switch I region; other site 199310013924 G3 box; other site 199310013925 Switch II region; other site 199310013926 G4 box; other site 199310013927 G5 box; other site 199310013928 YjcZ-like protein; Region: YjcZ; pfam13990 199310013929 proline/glycine betaine transporter; Provisional; Region: PRK10642 199310013930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310013931 putative substrate translocation pore; other site 199310013932 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 199310013933 sensor protein BasS/PmrB; Provisional; Region: PRK10755 199310013934 HAMP domain; Region: HAMP; pfam00672 199310013935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310013936 dimer interface [polypeptide binding]; other site 199310013937 phosphorylation site [posttranslational modification] 199310013938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310013939 ATP binding site [chemical binding]; other site 199310013940 Mg2+ binding site [ion binding]; other site 199310013941 G-X-G motif; other site 199310013942 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 199310013943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310013944 active site 199310013945 phosphorylation site [posttranslational modification] 199310013946 intermolecular recognition site; other site 199310013947 dimerization interface [polypeptide binding]; other site 199310013948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310013949 DNA binding site [nucleotide binding] 199310013950 putative metal dependent hydrolase; Provisional; Region: PRK11598 199310013951 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 199310013952 Sulfatase; Region: Sulfatase; pfam00884 199310013953 arginine:agmatin antiporter; Provisional; Region: PRK10644 199310013954 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 199310013955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013956 arginine decarboxylase; Provisional; Region: PRK15029 199310013957 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 199310013958 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 199310013959 homodimer interface [polypeptide binding]; other site 199310013960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310013961 catalytic residue [active] 199310013962 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 199310013963 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 199310013964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310013966 alpha-galactosidase; Provisional; Region: PRK15076 199310013967 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 199310013968 NAD binding site [chemical binding]; other site 199310013969 sugar binding site [chemical binding]; other site 199310013970 divalent metal binding site [ion binding]; other site 199310013971 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 199310013972 dimer interface [polypeptide binding]; other site 199310013973 fumarate hydratase; Provisional; Region: PRK15389 199310013974 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 199310013975 Fumarase C-terminus; Region: Fumerase_C; pfam05683 199310013976 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 199310013977 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 199310013978 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 199310013979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310013980 active site 199310013981 phosphorylation site [posttranslational modification] 199310013982 intermolecular recognition site; other site 199310013983 dimerization interface [polypeptide binding]; other site 199310013984 Transcriptional regulator; Region: CitT; pfam12431 199310013985 sensory histidine kinase DcuS; Provisional; Region: PRK11086 199310013986 PAS domain; Region: PAS; smart00091 199310013987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310013988 ATP binding site [chemical binding]; other site 199310013989 Mg2+ binding site [ion binding]; other site 199310013990 G-X-G motif; other site 199310013991 Uncharacterized conserved protein [Function unknown]; Region: COG3592 199310013992 Predicted acetyltransferase [General function prediction only]; Region: COG2388 199310013993 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 199310013994 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 199310013995 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 199310013996 dimer interface [polypeptide binding]; other site 199310013997 putative anticodon binding site; other site 199310013998 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 199310013999 motif 1; other site 199310014000 active site 199310014001 motif 2; other site 199310014002 motif 3; other site 199310014003 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 199310014004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310014005 putative substrate translocation pore; other site 199310014006 POT family; Region: PTR2; pfam00854 199310014007 lysine decarboxylase CadA; Provisional; Region: PRK15400 199310014008 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 199310014009 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 199310014010 homodimer interface [polypeptide binding]; other site 199310014011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 199310014012 catalytic residue [active] 199310014013 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 199310014014 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 199310014015 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 199310014016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310014017 DNA binding site [nucleotide binding] 199310014018 Methyltransferase domain; Region: Methyltransf_27; pfam13708 199310014019 Integrase core domain; Region: rve; pfam00665 199310014020 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 199310014021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310014022 Walker A motif; other site 199310014023 ATP binding site [chemical binding]; other site 199310014024 Walker B motif; other site 199310014025 Methyltransferase domain; Region: Methyltransf_27; pfam13708 199310014026 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 199310014027 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 199310014028 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 199310014029 Protein of unknown function (DUF987); Region: DUF987; pfam06174 199310014030 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 199310014031 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 199310014032 MPN+ (JAMM) motif; other site 199310014033 Zinc-binding site [ion binding]; other site 199310014034 Antirestriction protein; Region: Antirestrict; pfam03230 199310014035 Domain of unknown function (DUF932); Region: DUF932; pfam06067 199310014036 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 199310014037 HTH domain; Region: HTH_11; cl17392 199310014038 WYL domain; Region: WYL; pfam13280 199310014039 Predicted GTPase [General function prediction only]; Region: COG3596 199310014040 YfjP GTPase; Region: YfjP; cd11383 199310014041 G1 box; other site 199310014042 GTP/Mg2+ binding site [chemical binding]; other site 199310014043 Switch I region; other site 199310014044 G2 box; other site 199310014045 Switch II region; other site 199310014046 G3 box; other site 199310014047 G4 box; other site 199310014048 G5 box; other site 199310014049 Integrase core domain; Region: rve_3; cl15866 199310014050 HTH-like domain; Region: HTH_21; pfam13276 199310014051 Integrase core domain; Region: rve; pfam00665 199310014052 Transposase; Region: HTH_Tnp_1; cl17663 199310014053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310014054 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310014055 putative iron-regulated outer membrane virulence protein; Provisional; Region: PRK13484 199310014056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 199310014057 N-terminal plug; other site 199310014058 ligand-binding site [chemical binding]; other site 199310014059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 199310014060 Transposase, Mutator family; Region: Transposase_mut; pfam00872 199310014061 MULE transposase domain; Region: MULE; pfam10551 199310014062 Transposase; Region: HTH_Tnp_1; cl17663 199310014063 putative transposase OrfB; Reviewed; Region: PHA02517 199310014064 HTH-like domain; Region: HTH_21; pfam13276 199310014065 Integrase core domain; Region: rve; pfam00665 199310014066 Integrase core domain; Region: rve_3; pfam13683 199310014067 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 199310014068 putative membrane interaction site; other site 199310014069 receptor/carbohydrate binding site; other site 199310014070 PapG chaperone-binding domain; Region: PapG_C; pfam03628 199310014071 Fimbrial protein; Region: Fimbrial; pfam00419 199310014072 Fimbrial protein; Region: Fimbrial; pfam00419 199310014073 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310014074 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 199310014075 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310014076 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310014077 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 199310014078 PapC N-terminal domain; Region: PapC_N; pfam13954 199310014079 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310014080 PapC C-terminal domain; Region: PapC_C; pfam13953 199310014081 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310014082 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310014083 FaeA-like protein; Region: FaeA; pfam04703 199310014084 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 199310014085 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310014086 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 199310014087 Transposase; Region: HTH_Tnp_1; cl17663 199310014088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310014089 HTH-like domain; Region: HTH_21; pfam13276 199310014090 Integrase core domain; Region: rve; pfam00665 199310014091 Integrase core domain; Region: rve_3; pfam13683 199310014092 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 199310014093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310014094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310014095 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 199310014096 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 199310014097 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 199310014098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310014099 dimer interface [polypeptide binding]; other site 199310014100 phosphorylation site [posttranslational modification] 199310014101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310014102 ATP binding site [chemical binding]; other site 199310014103 G-X-G motif; other site 199310014104 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 199310014105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310014106 active site 199310014107 phosphorylation site [posttranslational modification] 199310014108 intermolecular recognition site; other site 199310014109 dimerization interface [polypeptide binding]; other site 199310014110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 199310014111 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 199310014112 PerC transcriptional activator; Region: PerC; pfam06069 199310014113 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 199310014114 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 199310014115 ParB-like nuclease domain; Region: ParB; smart00470 199310014116 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 199310014117 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 199310014118 Active Sites [active] 199310014119 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 199310014120 AAA domain; Region: AAA_21; pfam13304 199310014121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310014122 Walker B; other site 199310014123 D-loop; other site 199310014124 H-loop/switch region; other site 199310014125 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 199310014126 putative active site [active] 199310014127 putative metal-binding site [ion binding]; other site 199310014128 putative transposase OrfB; Reviewed; Region: PHA02517 199310014129 HTH-like domain; Region: HTH_21; pfam13276 199310014130 Integrase core domain; Region: rve; pfam00665 199310014131 Integrase core domain; Region: rve_3; pfam13683 199310014132 Transposase; Region: HTH_Tnp_1; cl17663 199310014133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 199310014134 Part of AAA domain; Region: AAA_19; pfam13245 199310014135 integrase; Provisional; Region: PRK09692 199310014136 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310014137 active site 199310014138 Int/Topo IB signature motif; other site 199310014139 putative transcriptional regulator; Provisional; Region: PRK11640 199310014140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310014141 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 199310014142 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 199310014143 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 199310014144 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 199310014145 DsbD alpha interface [polypeptide binding]; other site 199310014146 catalytic residues [active] 199310014147 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 199310014148 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 199310014149 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 199310014150 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 199310014151 Aspartase; Region: Aspartase; cd01357 199310014152 active sites [active] 199310014153 tetramer interface [polypeptide binding]; other site 199310014154 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 199310014155 putative transporter; Provisional; Region: PRK11021 199310014156 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 199310014157 oligomerisation interface [polypeptide binding]; other site 199310014158 mobile loop; other site 199310014159 roof hairpin; other site 199310014160 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 199310014161 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 199310014162 ring oligomerisation interface [polypeptide binding]; other site 199310014163 ATP/Mg binding site [chemical binding]; other site 199310014164 stacking interactions; other site 199310014165 hinge regions; other site 199310014166 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 199310014167 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 199310014168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310014169 FeS/SAM binding site; other site 199310014170 elongation factor P; Validated; Region: PRK00529 199310014171 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 199310014172 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 199310014173 RNA binding site [nucleotide binding]; other site 199310014174 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 199310014175 RNA binding site [nucleotide binding]; other site 199310014176 entericidin A; Provisional; Region: PRK09810 199310014177 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 199310014178 multidrug efflux system protein; Provisional; Region: PRK11431 199310014179 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 199310014180 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 199310014181 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 199310014182 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 199310014183 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 199310014184 Iron-sulfur protein interface; other site 199310014185 proximal quinone binding site [chemical binding]; other site 199310014186 C-subunit interface; other site 199310014187 distal quinone binding site; other site 199310014188 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 199310014189 D-subunit interface [polypeptide binding]; other site 199310014190 Iron-sulfur protein interface; other site 199310014191 proximal quinone binding site [chemical binding]; other site 199310014192 distal quinone binding site [chemical binding]; other site 199310014193 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 199310014194 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 199310014195 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 199310014196 L-aspartate oxidase; Provisional; Region: PRK06175 199310014197 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 199310014198 poxB regulator PoxA; Provisional; Region: PRK09350 199310014199 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 199310014200 motif 1; other site 199310014201 dimer interface [polypeptide binding]; other site 199310014202 active site 199310014203 motif 2; other site 199310014204 motif 3; other site 199310014205 inner membrane transporter YjeM; Provisional; Region: PRK15238 199310014206 putative mechanosensitive channel protein; Provisional; Region: PRK10929 199310014207 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 199310014208 DNA-binding site [nucleotide binding]; DNA binding site 199310014209 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 199310014210 Mechanosensitive ion channel; Region: MS_channel; pfam00924 199310014211 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 199310014212 GTPase RsgA; Reviewed; Region: PRK12288 199310014213 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 199310014214 RNA binding site [nucleotide binding]; other site 199310014215 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 199310014216 GTPase/Zn-binding domain interface [polypeptide binding]; other site 199310014217 GTP/Mg2+ binding site [chemical binding]; other site 199310014218 G4 box; other site 199310014219 G5 box; other site 199310014220 G1 box; other site 199310014221 Switch I region; other site 199310014222 G2 box; other site 199310014223 G3 box; other site 199310014224 Switch II region; other site 199310014225 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 199310014226 catalytic site [active] 199310014227 putative active site [active] 199310014228 putative substrate binding site [chemical binding]; other site 199310014229 dimer interface [polypeptide binding]; other site 199310014230 epoxyqueuosine reductase; Region: TIGR00276 199310014231 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 199310014232 putative carbohydrate kinase; Provisional; Region: PRK10565 199310014233 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 199310014234 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 199310014235 putative substrate binding site [chemical binding]; other site 199310014236 putative ATP binding site [chemical binding]; other site 199310014237 ADP-binding protein; Provisional; Region: PRK10646 199310014238 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 199310014239 AMIN domain; Region: AMIN; pfam11741 199310014240 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 199310014241 active site 199310014242 metal binding site [ion binding]; metal-binding site 199310014243 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 199310014244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310014245 ATP binding site [chemical binding]; other site 199310014246 Mg2+ binding site [ion binding]; other site 199310014247 G-X-G motif; other site 199310014248 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 199310014249 ATP binding site [chemical binding]; other site 199310014250 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 199310014251 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 199310014252 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 199310014253 bacterial Hfq-like; Region: Hfq; cd01716 199310014254 hexamer interface [polypeptide binding]; other site 199310014255 Sm1 motif; other site 199310014256 RNA binding site [nucleotide binding]; other site 199310014257 Sm2 motif; other site 199310014258 GTPase HflX; Provisional; Region: PRK11058 199310014259 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 199310014260 HflX GTPase family; Region: HflX; cd01878 199310014261 G1 box; other site 199310014262 GTP/Mg2+ binding site [chemical binding]; other site 199310014263 Switch I region; other site 199310014264 G2 box; other site 199310014265 G3 box; other site 199310014266 Switch II region; other site 199310014267 G4 box; other site 199310014268 G5 box; other site 199310014269 FtsH protease regulator HflK; Provisional; Region: PRK10930 199310014270 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 199310014271 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 199310014272 FtsH protease regulator HflC; Provisional; Region: PRK11029 199310014273 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 199310014274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 199310014275 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 199310014276 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 199310014277 GDP-binding site [chemical binding]; other site 199310014278 ACT binding site; other site 199310014279 IMP binding site; other site 199310014280 Predicted transcriptional regulator [Transcription]; Region: COG1959 199310014281 transcriptional repressor NsrR; Provisional; Region: PRK11014 199310014282 exoribonuclease R; Provisional; Region: PRK11642 199310014283 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 199310014284 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 199310014285 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 199310014286 RNB domain; Region: RNB; pfam00773 199310014287 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 199310014288 RNA binding site [nucleotide binding]; other site 199310014289 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 199310014290 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 199310014291 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 199310014292 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 199310014293 PspA/IM30 family; Region: PspA_IM30; pfam04012 199310014294 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 199310014295 Predicted membrane protein [Function unknown]; Region: COG3766 199310014296 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 199310014297 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 199310014298 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 199310014299 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 199310014300 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 199310014301 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 199310014302 FAD binding site [chemical binding]; other site 199310014303 substrate binding site [chemical binding]; other site 199310014304 catalytic residues [active] 199310014305 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310014306 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 199310014307 esterase; Provisional; Region: PRK10566 199310014308 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 199310014309 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 199310014310 transcriptional repressor UlaR; Provisional; Region: PRK13509 199310014311 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 199310014312 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 199310014313 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 199310014314 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 199310014315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 199310014316 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 199310014317 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 199310014318 active site 199310014319 P-loop; other site 199310014320 phosphorylation site [posttranslational modification] 199310014321 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 199310014322 active site 199310014323 phosphorylation site [posttranslational modification] 199310014324 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 199310014325 active site 199310014326 dimer interface [polypeptide binding]; other site 199310014327 magnesium binding site [ion binding]; other site 199310014328 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 199310014329 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 199310014330 AP (apurinic/apyrimidinic) site pocket; other site 199310014331 DNA interaction; other site 199310014332 Metal-binding active site; metal-binding site 199310014333 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 199310014334 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 199310014335 intersubunit interface [polypeptide binding]; other site 199310014336 active site 199310014337 Zn2+ binding site [ion binding]; other site 199310014338 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 199310014339 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 199310014340 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 199310014341 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 199310014342 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 199310014343 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 199310014344 Helix-turn-helix domain; Region: HTH_31; pfam13560 199310014345 sequence-specific DNA binding site [nucleotide binding]; other site 199310014346 salt bridge; other site 199310014347 HipA-like N-terminal domain; Region: HipA_N; pfam07805 199310014348 HipA-like C-terminal domain; Region: HipA_C; pfam07804 199310014349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 199310014350 D-galactonate transporter; Region: 2A0114; TIGR00893 199310014351 putative substrate translocation pore; other site 199310014352 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 199310014353 L-aspartate oxidase; Provisional; Region: PRK06175 199310014354 L-aspartate oxidase; Provisional; Region: PRK06175 199310014355 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 199310014356 Coenzyme A transferase; Region: CoA_trans; smart00882 199310014357 Coenzyme A transferase; Region: CoA_trans; cl17247 199310014358 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 199310014359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 199310014360 substrate binding site [chemical binding]; other site 199310014361 oxyanion hole (OAH) forming residues; other site 199310014362 trimer interface [polypeptide binding]; other site 199310014363 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 199310014364 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 199310014365 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 199310014366 putative NAD(P) binding site [chemical binding]; other site 199310014367 active site 199310014368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 199310014369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 199310014370 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 199310014371 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 199310014372 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 199310014373 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 199310014374 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 199310014375 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 199310014376 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 199310014377 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 199310014378 Hemerythrin-like domain; Region: Hr-like; cd12108 199310014379 Fe binding site [ion binding]; other site 199310014380 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 199310014381 EamA-like transporter family; Region: EamA; pfam00892 199310014382 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 199310014383 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 199310014384 NADP binding site [chemical binding]; other site 199310014385 Predicted transcriptional regulators [Transcription]; Region: COG1733 199310014386 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 199310014387 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 199310014388 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 199310014389 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 199310014390 active site 199310014391 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 199310014392 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 199310014393 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 199310014394 Domain of unknown function DUF21; Region: DUF21; pfam01595 199310014395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 199310014396 Transporter associated domain; Region: CorC_HlyC; smart01091 199310014397 methionine sulfoxide reductase A; Provisional; Region: PRK00058 199310014398 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 199310014399 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 199310014400 Surface antigen; Region: Bac_surface_Ag; pfam01103 199310014401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 199310014402 Family of unknown function (DUF490); Region: DUF490; pfam04357 199310014403 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 199310014404 putative active site pocket [active] 199310014405 dimerization interface [polypeptide binding]; other site 199310014406 putative catalytic residue [active] 199310014407 Sel1-like repeats; Region: SEL1; smart00671 199310014408 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 199310014409 Sel1-like repeats; Region: SEL1; smart00671 199310014410 Sel1-like repeats; Region: SEL1; smart00671 199310014411 Sel1-like repeats; Region: SEL1; smart00671 199310014412 Sel1-like repeats; Region: SEL1; smart00671 199310014413 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 199310014414 Sel1-like repeats; Region: SEL1; smart00671 199310014415 Sel1-like repeats; Region: SEL1; smart00671 199310014416 Sel1-like repeats; Region: SEL1; smart00671 199310014417 Sel1-like repeats; Region: SEL1; smart00671 199310014418 Sel1-like repeats; Region: SEL1; smart00671 199310014419 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 199310014420 dimer interface [polypeptide binding]; other site 199310014421 substrate binding site [chemical binding]; other site 199310014422 metal binding sites [ion binding]; metal-binding site 199310014423 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 199310014424 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 199310014425 putative ligand binding site [chemical binding]; other site 199310014426 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 199310014427 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 199310014428 Walker A/P-loop; other site 199310014429 ATP binding site [chemical binding]; other site 199310014430 Q-loop/lid; other site 199310014431 ABC transporter signature motif; other site 199310014432 Walker B; other site 199310014433 D-loop; other site 199310014434 H-loop/switch region; other site 199310014435 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 199310014436 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310014437 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310014438 TM-ABC transporter signature motif; other site 199310014439 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 199310014440 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 199310014441 TM-ABC transporter signature motif; other site 199310014442 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 199310014443 AMP binding site [chemical binding]; other site 199310014444 metal binding site [ion binding]; metal-binding site 199310014445 active site 199310014446 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 199310014447 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 199310014448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 199310014449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 199310014450 hypothetical protein; Provisional; Region: PRK05255 199310014451 peptidase PmbA; Provisional; Region: PRK11040 199310014452 cytochrome b562; Provisional; Region: PRK15058 199310014453 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 199310014454 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310014455 FeS/SAM binding site; other site 199310014456 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 199310014457 ATP cone domain; Region: ATP-cone; pfam03477 199310014458 Class III ribonucleotide reductase; Region: RNR_III; cd01675 199310014459 effector binding site; other site 199310014460 active site 199310014461 Zn binding site [ion binding]; other site 199310014462 glycine loop; other site 199310014463 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 199310014464 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 199310014465 Ca binding site [ion binding]; other site 199310014466 active site 199310014467 catalytic site [active] 199310014468 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 199310014469 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 199310014470 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 199310014471 active site turn [active] 199310014472 phosphorylation site [posttranslational modification] 199310014473 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 199310014474 trehalose repressor; Provisional; Region: treR; PRK09492 199310014475 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310014476 DNA binding site [nucleotide binding] 199310014477 domain linker motif; other site 199310014478 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 199310014479 dimerization interface [polypeptide binding]; other site 199310014480 ligand binding site [chemical binding]; other site 199310014481 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 199310014482 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 199310014483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 199310014484 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 199310014485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310014486 motif II; other site 199310014487 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 199310014488 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 199310014489 homotrimer interaction site [polypeptide binding]; other site 199310014490 putative active site [active] 199310014491 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 199310014492 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 199310014493 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 199310014494 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 199310014495 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 199310014496 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 199310014497 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 199310014498 Arginine repressor [Transcription]; Region: ArgR; COG1438 199310014499 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 199310014500 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 199310014501 Predicted membrane protein [Function unknown]; Region: COG1288 199310014502 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 199310014503 ornithine carbamoyltransferase; Validated; Region: PRK02102 199310014504 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 199310014505 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 199310014506 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 199310014507 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 199310014508 putative substrate binding site [chemical binding]; other site 199310014509 nucleotide binding site [chemical binding]; other site 199310014510 nucleotide binding site [chemical binding]; other site 199310014511 homodimer interface [polypeptide binding]; other site 199310014512 arginine deiminase; Provisional; Region: PRK01388 199310014513 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 199310014514 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 199310014515 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 199310014516 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 199310014517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 199310014518 RNase E inhibitor protein; Provisional; Region: PRK11191 199310014519 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 199310014520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310014521 Coenzyme A binding pocket [chemical binding]; other site 199310014522 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 199310014523 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 199310014524 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 199310014525 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 199310014526 HIGH motif; other site 199310014527 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 199310014528 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 199310014529 active site 199310014530 KMSKS motif; other site 199310014531 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 199310014532 tRNA binding surface [nucleotide binding]; other site 199310014533 anticodon binding site; other site 199310014534 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 199310014535 DNA polymerase III subunit chi; Validated; Region: PRK05728 199310014536 multifunctional aminopeptidase A; Provisional; Region: PRK00913 199310014537 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 199310014538 interface (dimer of trimers) [polypeptide binding]; other site 199310014539 Substrate-binding/catalytic site; other site 199310014540 Zn-binding sites [ion binding]; other site 199310014541 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 199310014542 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 199310014543 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 199310014544 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 199310014545 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 199310014546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 199310014547 Walker A motif; other site 199310014548 ATP binding site [chemical binding]; other site 199310014549 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 199310014550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 199310014551 DNA binding site [nucleotide binding] 199310014552 domain linker motif; other site 199310014553 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 199310014554 putative dimerization interface [polypeptide binding]; other site 199310014555 putative ligand binding site [chemical binding]; other site 199310014556 fructuronate transporter; Provisional; Region: PRK10034; cl15264 199310014557 gluconate transporter; Region: gntP; TIGR00791 199310014558 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 199310014559 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 199310014560 NADP binding site [chemical binding]; other site 199310014561 homodimer interface [polypeptide binding]; other site 199310014562 active site 199310014563 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 199310014564 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 199310014565 putative NAD(P) binding site [chemical binding]; other site 199310014566 catalytic Zn binding site [ion binding]; other site 199310014567 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 199310014568 ATP-binding site [chemical binding]; other site 199310014569 Gluconate-6-phosphate binding site [chemical binding]; other site 199310014570 Shikimate kinase; Region: SKI; pfam01202 199310014571 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 199310014572 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 199310014573 putative NAD(P) binding site [chemical binding]; other site 199310014574 putative substrate binding site [chemical binding]; other site 199310014575 catalytic Zn binding site [ion binding]; other site 199310014576 structural Zn binding site [ion binding]; other site 199310014577 dimer interface [polypeptide binding]; other site 199310014578 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 199310014579 active site 199310014580 Int/Topo IB signature motif; other site 199310014581 Restriction endonuclease [Defense mechanisms]; Region: COG3587 199310014582 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 199310014583 ATP binding site [chemical binding]; other site 199310014584 putative Mg++ binding site [ion binding]; other site 199310014585 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 199310014586 DNA methylase; Region: N6_N4_Mtase; cl17433 199310014587 DNA methylase; Region: N6_N4_Mtase; pfam01555 199310014588 DNA methylase; Region: N6_N4_Mtase; cl17433 199310014589 Family description; Region: UvrD_C_2; pfam13538 199310014590 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 199310014591 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 199310014592 putative active site [active] 199310014593 catalytic site [active] 199310014594 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 199310014595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310014596 ATP binding site [chemical binding]; other site 199310014597 putative Mg++ binding site [ion binding]; other site 199310014598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 199310014599 nucleotide binding region [chemical binding]; other site 199310014600 ATP-binding site [chemical binding]; other site 199310014601 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 199310014602 WYL domain; Region: WYL; pfam13280 199310014603 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 199310014604 Protein of unknown function DUF91; Region: DUF91; cl00709 199310014605 Winged helix-turn helix; Region: HTH_33; pfam13592 199310014606 DDE superfamily endonuclease; Region: DDE_3; pfam13358 199310014607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 199310014608 Homeodomain-like domain; Region: HTH_23; pfam13384 199310014609 Winged helix-turn helix; Region: HTH_29; pfam13551 199310014610 Domain of unknown function (DUF303); Region: DUF303; pfam03629 199310014611 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 199310014612 Kelch motif; Region: Kelch_1; pfam01344 199310014613 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 199310014614 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 199310014615 Int/Topo IB signature motif; other site 199310014616 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 199310014617 Int/Topo IB signature motif; other site 199310014618 Fimbrial protein; Region: Fimbrial; cl01416 199310014619 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310014620 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 199310014621 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 199310014622 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 199310014623 outer membrane usher protein; Provisional; Region: PRK15193 199310014624 PapC N-terminal domain; Region: PapC_N; pfam13954 199310014625 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 199310014626 PapC C-terminal domain; Region: PapC_C; pfam13953 199310014627 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310014628 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 199310014629 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 199310014630 mannosyl binding site [chemical binding]; other site 199310014631 Fimbrial protein; Region: Fimbrial; pfam00419 199310014632 fructuronate transporter; Provisional; Region: PRK10034 199310014633 gluconate transporter; Region: gntP; TIGR00791 199310014634 mannonate dehydratase; Region: uxuA; TIGR00695 199310014635 mannonate dehydratase; Provisional; Region: PRK03906 199310014636 D-mannonate oxidoreductase; Provisional; Region: PRK15037 199310014637 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 199310014638 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 199310014639 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 199310014640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310014641 DNA-binding site [nucleotide binding]; DNA binding site 199310014642 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310014643 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 199310014644 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 199310014645 cell density-dependent motility repressor; Provisional; Region: PRK10082 199310014646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 199310014647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 199310014648 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 199310014649 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 199310014650 dimer interface [polypeptide binding]; other site 199310014651 active site 199310014652 hypothetical protein; Provisional; Region: PRK10519 199310014653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 199310014654 Nucleoside recognition; Region: Gate; pfam07670 199310014655 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 199310014656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 199310014657 SdiA-regulated; Region: SdiA-regulated; cd09971 199310014658 putative active site [active] 199310014659 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 199310014660 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 199310014661 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 199310014662 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 199310014663 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 199310014664 Predicted membrane protein [Function unknown]; Region: COG2733 199310014665 putative transposase; Provisional; Region: PRK09857 199310014666 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 199310014667 Uncharacterized conserved protein [Function unknown]; Region: COG1479 199310014668 Protein of unknown function DUF262; Region: DUF262; pfam03235 199310014669 Protein of unknown function DUF262; Region: DUF262; pfam03235 199310014670 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 199310014671 Uncharacterized conserved protein [Function unknown]; Region: COG3586 199310014672 endoribonuclease SymE; Provisional; Region: PRK13605 199310014673 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 199310014674 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 199310014675 HsdM N-terminal domain; Region: HsdM_N; pfam12161 199310014676 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 199310014677 Methyltransferase domain; Region: Methyltransf_26; pfam13659 199310014678 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 199310014679 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 199310014680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 199310014681 ATP binding site [chemical binding]; other site 199310014682 putative Mg++ binding site [ion binding]; other site 199310014683 Uncharacterized conserved protein [Function unknown]; Region: COG1479 199310014684 Protein of unknown function DUF262; Region: DUF262; pfam03235 199310014685 Protein of unknown function DUF262; Region: DUF262; pfam03235 199310014686 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 199310014687 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 199310014688 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 199310014689 P-loop, Walker A motif; other site 199310014690 Base recognition motif; other site 199310014691 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 199310014692 Uncharacterized small protein [Function unknown]; Region: COG2879 199310014693 carbon starvation protein A; Provisional; Region: PRK15015 199310014694 Carbon starvation protein CstA; Region: CstA; pfam02554 199310014695 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 199310014696 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 199310014697 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 199310014698 dimer interface [polypeptide binding]; other site 199310014699 ligand binding site [chemical binding]; other site 199310014700 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310014701 dimerization interface [polypeptide binding]; other site 199310014702 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 199310014703 dimer interface [polypeptide binding]; other site 199310014704 putative CheW interface [polypeptide binding]; other site 199310014705 DctM-like transporters; Region: DctM; pfam06808 199310014706 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 199310014707 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 199310014708 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 199310014709 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 199310014710 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 199310014711 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 199310014712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 199310014713 DNA-binding site [nucleotide binding]; DNA binding site 199310014714 Transcriptional regulators [Transcription]; Region: GntR; COG1802 199310014715 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 199310014716 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 199310014717 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 199310014718 putative NAD(P) binding site [chemical binding]; other site 199310014719 catalytic Zn binding site [ion binding]; other site 199310014720 structural Zn binding site [ion binding]; other site 199310014721 phosphoglycerol transferase I; Provisional; Region: PRK03776 199310014722 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 199310014723 hypothetical protein; Provisional; Region: PRK11667 199310014724 DNA replication protein DnaC; Validated; Region: PRK07952 199310014725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 199310014726 Walker A motif; other site 199310014727 ATP binding site [chemical binding]; other site 199310014728 Walker B motif; other site 199310014729 primosomal protein DnaI; Provisional; Region: PRK02854 199310014730 hypothetical protein; Provisional; Region: PRK09917 199310014731 Uncharacterized conserved protein [Function unknown]; Region: COG2966 199310014732 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 199310014733 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 199310014734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310014735 DNA binding residues [nucleotide binding] 199310014736 dimerization interface [polypeptide binding]; other site 199310014737 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 199310014738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 199310014739 DNA binding residues [nucleotide binding] 199310014740 dimerization interface [polypeptide binding]; other site 199310014741 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 199310014742 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 199310014743 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 199310014744 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 199310014745 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 199310014746 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 199310014747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 199310014748 S-adenosylmethionine binding site [chemical binding]; other site 199310014749 DNA polymerase III subunit psi; Validated; Region: PRK06856 199310014750 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 199310014751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 199310014752 Coenzyme A binding pocket [chemical binding]; other site 199310014753 dUMP phosphatase; Provisional; Region: PRK09449 199310014754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310014755 motif II; other site 199310014756 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 199310014757 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 199310014758 G1 box; other site 199310014759 putative GEF interaction site [polypeptide binding]; other site 199310014760 GTP/Mg2+ binding site [chemical binding]; other site 199310014761 Switch I region; other site 199310014762 G2 box; other site 199310014763 G3 box; other site 199310014764 Switch II region; other site 199310014765 G4 box; other site 199310014766 G5 box; other site 199310014767 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 199310014768 periplasmic protein; Provisional; Region: PRK10568 199310014769 BON domain; Region: BON; pfam04972 199310014770 BON domain; Region: BON; pfam04972 199310014771 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 199310014772 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 199310014773 active site 199310014774 nucleophile elbow; other site 199310014775 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 199310014776 active site 199310014777 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 199310014778 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 199310014779 FeS/SAM binding site; other site 199310014780 hypothetical protein; Provisional; Region: PRK10977 199310014781 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 199310014782 intersubunit interface [polypeptide binding]; other site 199310014783 active site 199310014784 catalytic residue [active] 199310014785 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 199310014786 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 199310014787 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 199310014788 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 199310014789 phosphopentomutase; Provisional; Region: PRK05362 199310014790 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 199310014791 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 199310014792 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 199310014793 Transposase IS200 like; Region: Y1_Tnp; pfam01797 199310014794 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 199310014795 HipA-like N-terminal domain; Region: HipA_N; pfam07805 199310014796 HipA-like C-terminal domain; Region: HipA_C; pfam07804 199310014797 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 199310014798 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 199310014799 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 199310014800 hypothetical protein; Provisional; Region: PRK11246 199310014801 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 199310014802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 199310014803 motif II; other site 199310014804 DNA repair protein RadA; Region: sms; TIGR00416 199310014805 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 199310014806 Walker A motif/ATP binding site; other site 199310014807 ATP binding site [chemical binding]; other site 199310014808 Walker B motif; other site 199310014809 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 199310014810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310014811 non-specific DNA binding site [nucleotide binding]; other site 199310014812 salt bridge; other site 199310014813 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 199310014814 sequence-specific DNA binding site [nucleotide binding]; other site 199310014815 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 199310014816 active site 199310014817 (T/H)XGH motif; other site 199310014818 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 199310014819 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 199310014820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 199310014821 non-specific DNA binding site [nucleotide binding]; other site 199310014822 salt bridge; other site 199310014823 sequence-specific DNA binding site [nucleotide binding]; other site 199310014824 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 199310014825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 199310014826 Walker A/P-loop; other site 199310014827 ATP binding site [chemical binding]; other site 199310014828 Q-loop/lid; other site 199310014829 ABC transporter signature motif; other site 199310014830 Walker B; other site 199310014831 D-loop; other site 199310014832 H-loop/switch region; other site 199310014833 ABC transporter; Region: ABC_tran_2; pfam12848 199310014834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 199310014835 lytic murein transglycosylase; Provisional; Region: PRK11619 199310014836 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 199310014837 N-acetyl-D-glucosamine binding site [chemical binding]; other site 199310014838 catalytic residue [active] 199310014839 Trp operon repressor; Provisional; Region: PRK01381 199310014840 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 199310014841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 199310014842 catalytic core [active] 199310014843 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 199310014844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 199310014845 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 199310014846 hypothetical protein; Provisional; Region: PRK10756 199310014847 CreA protein; Region: CreA; pfam05981 199310014848 DNA-binding response regulator CreB; Provisional; Region: PRK11083 199310014849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310014850 active site 199310014851 phosphorylation site [posttranslational modification] 199310014852 intermolecular recognition site; other site 199310014853 dimerization interface [polypeptide binding]; other site 199310014854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310014855 DNA binding site [nucleotide binding] 199310014856 sensory histidine kinase CreC; Provisional; Region: PRK11100 199310014857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 199310014858 dimerization interface [polypeptide binding]; other site 199310014859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 199310014860 dimer interface [polypeptide binding]; other site 199310014861 phosphorylation site [posttranslational modification] 199310014862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 199310014863 ATP binding site [chemical binding]; other site 199310014864 Mg2+ binding site [ion binding]; other site 199310014865 G-X-G motif; other site 199310014866 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 199310014867 two-component response regulator; Provisional; Region: PRK11173 199310014868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 199310014869 active site 199310014870 phosphorylation site [posttranslational modification] 199310014871 intermolecular recognition site; other site 199310014872 dimerization interface [polypeptide binding]; other site 199310014873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 199310014874 DNA binding site [nucleotide binding] 199310014875 putative RNA methyltransferase; Provisional; Region: PRK10433 199310014876 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050