-- dump date 20140619_090911 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 439855000001 SEQ_END SEQ_END NC_010485.1 8909 8909 DR NC_010485.1; contig end 8909..8909 Escherichia coli SMS-3-5 439855000002 SEQ_END SEQ_END NC_010486.1 4074 4074 DR NC_010486.1; contig end 4074..4074 Escherichia coli SMS-3-5 439855000003 SEQ_END SEQ_END NC_010487.1 3565 3565 DR NC_010487.1; contig end 3565..3565 Escherichia coli SMS-3-5 439855000004 SEQ_END SEQ_END NC_010488.1 130440 130440 DR NC_010488.1; contig end 130440..130440 Escherichia coli SMS-3-5 439855000005 SEQ_END SEQ_END NC_010498.1 5068389 5068389 DR NC_010498.1; contig end 5068389..5068389 Escherichia coli SMS-3-5 YP_001739873.1 CDS EcSMS35_B0001 NC_010485.1 257 496 R identified by Glimmer3; putative; hypothetical protein complement(257..496) Escherichia coli SMS-3-5 6106603 YP_001739874.1 CDS mbeA NC_010485.1 661 2214 R identified by similarity to SP:P13658; match to protein family HMM PF03432; mobilization protein MbeA complement(661..2214) Escherichia coli SMS-3-5 6106604 YP_001739875.1 CDS mbeC NC_010485.1 2204 2551 R identified by similarity to SP:P13657; match to protein family HMM PF05713; mobilization protein MbeC complement(2204..2551) Escherichia coli SMS-3-5 6106613 YP_001739876.1 CDS rop NC_010485.1 2558 2782 D identified by similarity to SP:P03051; match to protein family HMM PF01815; regulatory protein Rop 2558..2782 Escherichia coli SMS-3-5 6106610 YP_001739877.1 CDS EcSMS35_B0005 NC_010485.1 2848 3096 R identified by Glimmer3; putative; hypothetical protein complement(2848..3096) Escherichia coli SMS-3-5 6106609 YP_001739878.1 CDS EcSMS35_B0006 NC_010485.1 3153 3524 D identified by similarity to GB:AAS58761.1; hypothetical protein 3153..3524 Escherichia coli SMS-3-5 6106606 YP_001739879.1 CDS imm NC_010485.1 3992 4333 D identified by similarity to SP:P02985; match to protein family HMM PF03526; colicin-E1 immunity protein 3992..4333 Escherichia coli SMS-3-5 6106612 YP_001739880.1 CDS cea NC_010485.1 4330 5895 R identified by similarity to SP:P21178; match to protein family HMM PF01024; colicin-E1 protein complement(4330..5895) Escherichia coli SMS-3-5 6106605 YP_001739881.1 CDS EcSMS35_B0009 NC_010485.1 6155 6592 D identified by similarity to GB:AAB59142.1; hypothetical protein 6155..6592 Escherichia coli SMS-3-5 6106607 YP_001739882.1 CDS EcSMS35_B0010 NC_010485.1 6676 7095 D putative lipoprotein 6676..7095 Escherichia coli SMS-3-5 6106608 YP_001739883.1 CDS repB NC_010486.1 165 866 D identified by match to protein family HMM PF01051; initiator replication protein RepB 165..866 Escherichia coli SMS-3-5 6106614 YP_001739884.1 CDS EcSMS35_C0002 NC_010486.1 1114 3273 R identified by match to protein family HMM PF03389; MobA/MobL family protein complement(1114..3273) Escherichia coli SMS-3-5 6106617 YP_001739885.1 CDS EcSMS35_C0004 NC_010486.1 3452 3706 D identified by similarity to SP:P07114; putative mobilization protein C 3452..3706 Escherichia coli SMS-3-5 6106616 YP_001739886.1 CDS EcSMS35_C0003 NC_010486.1 3675 4040 R identified by Glimmer3; putative; hypothetical protein complement(3675..4040) Escherichia coli SMS-3-5 6106615 YP_001739887.1 CDS EcSMS35_D0001 NC_010487.1 49 711 D identified by Glimmer3; putative; hypothetical protein 49..711 Escherichia coli SMS-3-5 6106618 YP_001739888.1 CDS EcSMS35_D0003 NC_010487.1 1627 2223 R identified by Glimmer3; putative; hypothetical protein complement(1627..2223) Escherichia coli SMS-3-5 6106619 YP_001739889.1 CDS EcSMS35_D0004 NC_010487.1 2633 2842 R identified by Glimmer3; putative; hypothetical protein complement(2633..2842) Escherichia coli SMS-3-5 6106621 YP_001739890.1 CDS EcSMS35_A0001 NC_010488.1 154 540 R replication initiation protein repA4 complement(154..540) Escherichia coli SMS-3-5 6106623 YP_001739891.1 CDS repA1 NC_010488.1 904 1773 R RepA; replication protein complement(904..1773) Escherichia coli SMS-3-5 6106557 YP_001739892.1 CDS repA2 NC_010488.1 2054 2314 R identified by similarity to SP:P62537; replication protein complement(2054..2314) Escherichia coli SMS-3-5 6106624 YP_001739893.1 CDS EcSMS35_A0005 NC_010488.1 3164 3373 R identified by similarity to SP:P0ACE3; match to protein family HMM PF05321; hypothetical protein complement(3164..3373) Escherichia coli SMS-3-5 6106571 YP_001739894.1 CDS EcSMS35_A0006 NC_010488.1 3419 3880 R identified by match to protein family HMM PF00565; nuclease homolog complement(3419..3880) Escherichia coli SMS-3-5 6106576 YP_001739895.1 CDS EcSMS35_A0007 NC_010488.1 4123 4335 R identified by similarity to RF:NP_958725.1; hypothetical protein complement(4123..4335) Escherichia coli SMS-3-5 6106495 YP_001739896.1 CDS finO NC_010488.1 4473 5084 R identified by similarity to SP:P22707; match to protein family HMM PF05286; conjugal transfer fertility inhibition protein FinO complement(4473..5084) Escherichia coli SMS-3-5 6106539 YP_001739897.1 CDS traX NC_010488.1 5088 5834 R identified by similarity to SP:P22709; match to protein family HMM PF05857; match to protein family HMM TIGR02755; conjugal transfer pilus acetylation protein TraX complement(5088..5834) Escherichia coli SMS-3-5 6106490 YP_001739898.1 CDS traI NC_010488.1 5854 11124 R cleaves origin of transfer and unwinds; oriT relaxase; conjugal transfer nickase/helicase TraI complement(5854..11124) Escherichia coli SMS-3-5 6106491 YP_001739899.1 CDS traD NC_010488.1 11124 13295 R type IV secretion system coupling protein; similar to F plasmid TraD; conjugal transfer protein TraD complement(11124..13295) Escherichia coli SMS-3-5 6106602 YP_001739900.1 CDS traT NC_010488.1 13548 14279 R identified by similarity to SP:P13979; match to protein family HMM PF05818; conjugal transfer surface exclusion protein TraT complement(13548..14279) Escherichia coli SMS-3-5 6106527 YP_001739901.1 CDS EcSMS35_A0013 NC_010488.1 14311 14808 R identified by similarity to GB:ABC42218.1; putative type IV secretion-like conjugative transfer system protein TraS complement(14311..14808) Escherichia coli SMS-3-5 6106516 YP_001739902.1 CDS traG NC_010488.1 14829 17651 R identified by similarity to SP:P33790; match to protein family HMM PF07916; conjugal transfer mating pair stabilization protein TraG complement(14829..17651) Escherichia coli SMS-3-5 6106512 YP_001739903.1 CDS traH NC_010488.1 17648 19024 R identified by similarity to SP:P15069; match to protein family HMM PF06122; conjugal transfer pilus assembly protein TraH complement(17648..19024) Escherichia coli SMS-3-5 6106505 YP_001739904.1 CDS trbJ NC_010488.1 19021 19383 R identified by similarity to SP:P18353; conjugal transfer protein TrbJ complement(19021..19383) Escherichia coli SMS-3-5 6106513 YP_001739905.1 CDS trbB NC_010488.1 19313 19858 R identified by similarity to SP:P18035; match to protein family HMM TIGR02738; conjugal transfer protein TrbB complement(19313..19858) Escherichia coli SMS-3-5 6106508 YP_001739906.1 CDS traQ NC_010488.1 19845 20129 R identified by similarity to SP:P18033; match to protein family HMM TIGR02741; conjugal transfer pilin chaperone TraQ complement(19845..20129) Escherichia coli SMS-3-5 6106589 YP_001739907.1 CDS trbA NC_010488.1 20248 20595 R identified by similarity to SP:P18034; conjugal transfer protein TrbA complement(20248..20595) Escherichia coli SMS-3-5 6106577 YP_001739908.1 CDS traF NC_010488.1 20611 21354 R type IV secretion system pilus assembly protein; similar to F plasmid TraF; conjugal pilus assembly protein TraF complement(20611..21354) Escherichia coli SMS-3-5 6106466 YP_001739909.1 CDS trbE NC_010488.1 21347 21604 R identified by similarity to SP:Q05807; conjugal transfer protein TrbE complement(21347..21604) Escherichia coli SMS-3-5 6106528 YP_001739910.1 CDS traN NC_010488.1 21631 23439 R TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell; conjugal transfer mating pair stabilization protein TraN complement(21631..23439) Escherichia coli SMS-3-5 6106499 YP_001739911.1 CDS trbC NC_010488.1 23436 24074 R identified by similarity to SP:P18473; match to protein family HMM TIGR02742; conjugal transfer pilus assembly protein TrbC complement(23436..24074) Escherichia coli SMS-3-5 6106494 YP_001739912.1 CDS EcSMS35_A0024 NC_010488.1 24102 24554 R identified by Glimmer3; putative; hypothetical protein complement(24102..24554) Escherichia coli SMS-3-5 6106579 YP_001739913.1 CDS EcSMS35_A0025 NC_010488.1 24584 25045 R identified by Glimmer3; putative; hypothetical protein complement(24584..25045) Escherichia coli SMS-3-5 6106551 YP_001739914.1 CDS traU NC_010488.1 25071 26063 R identified by similarity to SP:P18471; match to protein family HMM PF06834; conjugal transfer pilus assembly protein TraU complement(25071..26063) Escherichia coli SMS-3-5 6106486 YP_001739915.1 CDS traW NC_010488.1 26060 26692 R identified by similarity to SP:P18472; match to protein family HMM TIGR02743; conjugal transfer pilus assembly protein TraW complement(26060..26692) Escherichia coli SMS-3-5 6106485 YP_001739916.1 CDS trbI NC_010488.1 26689 27075 R identified by similarity to SP:P18006; match to protein family HMM TIGR02744; conjugal transfer protein TrbI complement(26689..27075) Escherichia coli SMS-3-5 6106479 YP_001739917.1 CDS traC NC_010488.1 27072 29699 R similar to VirB4; conjugal transfer ATP-binding protein TraC complement(27072..29699) Escherichia coli SMS-3-5 6106572 YP_001739918.1 CDS traR NC_010488.1 29859 30080 R identified by similarity to SP:P41065; match to protein family HMM PF01258; match to protein family HMM TIGR02419; conjugal transfer protein TraR complement(29859..30080) Escherichia coli SMS-3-5 6106553 YP_001739919.1 CDS traV NC_010488.1 30215 30730 R identified by similarity to SP:P41069; match to protein family HMM TIGR02747; conjugal transfer protein TraV complement(30215..30730) Escherichia coli SMS-3-5 6106549 YP_001739920.1 CDS EcSMS35_A0032 NC_010488.1 30727 30978 R identified by similarity to SP:P41072; conjugal transfer protein TrbG complement(30727..30978) Escherichia coli SMS-3-5 6106563 YP_001739921.1 CDS EcSMS35_A0033 NC_010488.1 30975 31292 R identified by similarity to SP:P41070; conjugal transfer protein TrbD complement(30975..31292) Escherichia coli SMS-3-5 6106462 YP_001739922.1 CDS traP NC_010488.1 31289 31861 R identified by similarity to SP:P41068; match to protein family HMM PF07296; conjugal transfer protein TraP complement(31289..31861) Escherichia coli SMS-3-5 6106538 YP_001739923.1 CDS traB NC_010488.1 31851 33278 R identified by similarity to SP:P41067; match to protein family HMM PF06447; conjugal transfer pilus assembly protein TraB complement(31851..33278) Escherichia coli SMS-3-5 6106630 YP_001739924.1 CDS traK NC_010488.1 33278 34006 R identified by similarity to SP:P41066; match to protein family HMM PF06586; match to protein family HMM TIGR02756; conjugal transfer protein TraK complement(33278..34006) Escherichia coli SMS-3-5 6106500 YP_001739925.1 CDS traE NC_010488.1 33993 34559 R identified by similarity to SP:P08322; match to protein family HMM PF05309; match to protein family HMM TIGR02761; conjugal transfer pilus assembly protein TraE complement(33993..34559) Escherichia coli SMS-3-5 6106467 YP_001739926.1 CDS traL NC_010488.1 34581 34892 R identified by similarity to SP:P08321; match to protein family HMM PF07178; match to protein family HMM TIGR02762; conjugal transfer pilus assembly protein TraL complement(34581..34892) Escherichia coli SMS-3-5 6106631 YP_001739927.1 CDS traA NC_010488.1 34907 35266 R identified by similarity to SP:P04737; match to protein family HMM PF05513; match to protein family HMM TIGR02758; conjugal transfer pilin subunit TraA complement(34907..35266) Escherichia coli SMS-3-5 6106451 YP_001739928.1 CDS traY NC_010488.1 35300 35527 R identified by similarity to SP:P05836; conjugal transfer protein TraY complement(35300..35527) Escherichia coli SMS-3-5 6106595 YP_001739929.1 CDS traJ NC_010488.1 35621 36307 R identified by similarity to SP:P05837; match to protein family HMM PF00989; type IV secretion-like conjugative transfer system regulator TraJ complement(35621..36307) Escherichia coli SMS-3-5 6106483 YP_001739930.1 CDS traM NC_010488.1 36498 36881 R identified by similarity to SP:P10026; match to protein family HMM PF05261; conjugal transfer protein TraM complement(36498..36881) Escherichia coli SMS-3-5 6106492 YP_001739931.1 CDS EcSMS35_A0043 NC_010488.1 37158 37805 D identified by match to protein family HMM PF01464; lytic transglycosylase 37158..37805 Escherichia coli SMS-3-5 6106509 YP_001739932.1 CDS EcSMS35_A0044 NC_010488.1 37831 37965 R identified by Glimmer3; putative; hypothetical protein complement(37831..37965) Escherichia coli SMS-3-5 6106511 YP_001739933.1 CDS EcSMS35_A0045 NC_010488.1 38102 38923 R identified by similarity to SP:P18005; match to protein family HMM PF06067; hypothetical protein complement(38102..38923) Escherichia coli SMS-3-5 6106480 YP_001739934.1 CDS EcSMS35_A0046 NC_010488.1 39046 39333 R identified by similarity to SP:Q02885; hypothetical protein complement(39046..39333) Escherichia coli SMS-3-5 6106590 YP_001739935.1 CDS EcSMS35_A0047 NC_010488.1 39358 39519 R identified by Glimmer3; putative; hypothetical protein complement(39358..39519) Escherichia coli SMS-3-5 6106622 YP_001739936.1 CDS EcSMS35_A0048 NC_010488.1 39600 39812 R identified by Glimmer3; putative; hypothetical protein complement(39600..39812) Escherichia coli SMS-3-5 6106520 YP_001739937.1 CDS EcSMS35_A0049 NC_010488.1 39805 39957 R identified by Glimmer3; putative; hypothetical protein complement(39805..39957) Escherichia coli SMS-3-5 6106473 YP_001739938.1 CDS hok NC_010488.1 40255 40413 R identified by similarity to SP:P11895; match to protein family HMM PF01848; small toxic polypeptide complement(40255..40413) Escherichia coli SMS-3-5 6106478 YP_001739939.1 CDS EcSMS35_A0051 NC_010488.1 40556 40693 R identified by Glimmer3; putative; hypothetical protein complement(40556..40693) Escherichia coli SMS-3-5 6106450 YP_001739940.1 CDS psiA NC_010488.1 40693 41412 R PsiA; plasmid SOS inhibition protein A complement(40693..41412) Escherichia coli SMS-3-5 6106522 YP_001739941.1 CDS psiB NC_010488.1 41409 41843 R identified by similarity to SP:P10032; match to protein family HMM PF06290; plasmid SOS inhibition protein B complement(41409..41843) Escherichia coli SMS-3-5 6106599 YP_001739942.1 CDS EcSMS35_A0054 NC_010488.1 41898 43862 R identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; ParB-like partition protein complement(41898..43862) Escherichia coli SMS-3-5 6106574 YP_001739943.1 CDS EcSMS35_A0055 NC_010488.1 43915 44148 R identified by similarity to SP:Q5QJF4; match to protein family HMM PF06006; hypothetical protein complement(43915..44148) Escherichia coli SMS-3-5 6106518 YP_001739944.1 CDS ssb1 NC_010488.1 44204 44731 R identified by similarity to SP:P28044; match to protein family HMM PF00436; match to protein family HMM TIGR00621; single-stranded DNA-binding protein complement(44204..44731) Escherichia coli SMS-3-5 6106536 YP_001739945.1 CDS EcSMS35_A0057 NC_010488.1 45374 45622 R identified by Glimmer3; putative; hypothetical protein complement(45374..45622) Escherichia coli SMS-3-5 6106496 YP_001739946.1 CDS EcSMS35_A0058 NC_010488.1 45622 46185 R identified by similarity to GB:AAR05681.1; hypothetical protein complement(45622..46185) Escherichia coli SMS-3-5 6106578 YP_001739947.1 CDS EcSMS35_A0059 NC_010488.1 46231 47592 R identified by similarity to GB:AAR05680.1; hypothetical protein complement(46231..47592) Escherichia coli SMS-3-5 6106587 YP_001739948.1 CDS EcSMS35_A0060 NC_010488.1 47644 47874 R identified by similarity to GB:AAR05679.1; hypothetical protein complement(47644..47874) Escherichia coli SMS-3-5 6106596 YP_001739949.1 CDS EcSMS35_A0061 NC_010488.1 48137 48394 D identified by Glimmer3; putative; hypothetical protein 48137..48394 Escherichia coli SMS-3-5 6106476 YP_001739950.1 CDS EcSMS35_A0062 NC_010488.1 48448 48738 R identified by Glimmer3; putative; hypothetical protein complement(48448..48738) Escherichia coli SMS-3-5 6106540 YP_001739951.1 CDS EcSMS35_A0063 NC_010488.1 48868 49050 R identified by similarity to GB:AAS76404.1; hypothetical protein complement(48868..49050) Escherichia coli SMS-3-5 6106477 YP_001739952.1 CDS EcSMS35_A0064 NC_010488.1 49050 49421 R identified by similarity to GB:AAS76405.1; hypothetical protein complement(49050..49421) Escherichia coli SMS-3-5 6106586 YP_001739953.1 CDS EcSMS35_A0065 NC_010488.1 49511 49936 R identified by match to protein family HMM PF03230; putative antirestriction protein complement(49511..49936) Escherichia coli SMS-3-5 6106489 YP_001739954.1 CDS EcSMS35_A0066 NC_010488.1 50016 50186 D identified by Glimmer3; putative; hypothetical protein 50016..50186 Escherichia coli SMS-3-5 6106559 YP_001739955.1 CDS EcSMS35_A0067 NC_010488.1 50338 51309 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS110 family transposase 50338..51309 Escherichia coli SMS-3-5 6106569 YP_001739956.1 CDS EcSMS35_A0068 NC_010488.1 51362 51865 R identified by similarity to SP:P03830; match to protein family HMM PF03400; IS1 transposase orfB complement(51362..51865) Escherichia coli SMS-3-5 6106546 YP_001739957.1 CDS EcSMS35_A0069 NC_010488.1 51876 52088 R identified by similarity to GB:ABB64642.1; IS1 transposase orfA complement(51876..52088) Escherichia coli SMS-3-5 6106503 YP_001739958.1 CDS EcSMS35_A0070 NC_010488.1 52514 52657 R identified by Glimmer3; putative; hypothetical protein complement(52514..52657) Escherichia coli SMS-3-5 6106583 YP_001739959.1 CDS EcSMS35_A0071 NC_010488.1 52623 53036 R identified by Glimmer3; putative; hypothetical protein complement(52623..53036) Escherichia coli SMS-3-5 6106458 YP_001739960.1 CDS sopB NC_010488.1 53664 54635 R SopB; plasmid-partitioning protein complement(53664..54635) Escherichia coli SMS-3-5 6106535 YP_001739961.1 CDS sopA NC_010488.1 54635 55810 R identified by similarity to SP:P62556; match to protein family HMM PF00376; match to protein family HMM PF01656; plasmid-partitioning protein SopA complement(54635..55810) Escherichia coli SMS-3-5 6106519 YP_001739962.1 CDS EcSMS35_A0074 NC_010488.1 56101 56604 R identified by match to protein family HMM PF03400; IS1 transposase orfB complement(56101..56604) Escherichia coli SMS-3-5 6106530 YP_001739963.1 CDS EcSMS35_A0075 NC_010488.1 56615 56827 R identified by similarity to GB:ABB64642.1; IS1 transposase orfA complement(56615..56827) Escherichia coli SMS-3-5 6106633 YP_001739964.1 CDS EcSMS35_A0076 NC_010488.1 56954 58456 R identified by similarity to GB:CAL13433.1; hypothetical protein complement(56954..58456) Escherichia coli SMS-3-5 6106573 YP_001739965.1 CDS EcSMS35_A0077 NC_010488.1 59056 59481 R identified by Glimmer3; putative; hypothetical protein complement(59056..59481) Escherichia coli SMS-3-5 6106552 YP_001739966.1 CDS EcSMS35_A0078 NC_010488.1 59638 60102 D identified by Glimmer3; putative; hypothetical protein 59638..60102 Escherichia coli SMS-3-5 6106488 YP_001739967.1 CDS EcSMS35_A0079 NC_010488.1 60178 60372 R identified by Glimmer3; putative; hypothetical protein complement(60178..60372) Escherichia coli SMS-3-5 6106484 YP_001739968.1 CDS EcSMS35_A0080 NC_010488.1 60602 60793 D identified by Glimmer3; putative; hypothetical protein 60602..60793 Escherichia coli SMS-3-5 6106632 YP_001739969.1 CDS sitD_1 NC_010488.1 61386 62243 R identified by similarity to GB:AAT11267.1; similarity to GB:ABA54734.1; match to protein family HMM PF00950; iron/manganese transport system membrane protein SitD complement(61386..62243) Escherichia coli SMS-3-5 6106550 YP_001739970.1 CDS sitC_1 NC_010488.1 62240 63097 R identified by similarity to GB:AAT11266.1; match to protein family HMM PF00950; match to protein family HMM PF01032; iron/manganese transport system membrane protein SitC complement(62240..63097) Escherichia coli SMS-3-5 6106461 YP_001739971.1 CDS sitB_1 NC_010488.1 63094 63921 R identified by similarity to GB:AAT11265.1; match to protein family HMM PF00005; iron/manganese transport system membrane protein SitB complement(63094..63921) Escherichia coli SMS-3-5 6106581 YP_001739972.1 CDS sitA_1 NC_010488.1 63921 64835 R identified by similarity to GB:AAT11264.1; match to protein family HMM PF01297; iron/manganese transport system periplasmic binding protein SitA complement(63921..64835) Escherichia coli SMS-3-5 6106487 YP_001739973.1 CDS EcSMS35_A0085 NC_010488.1 65162 65374 D identified by similarity to GB:ABB64642.1; IS1 transposase orfA 65162..65374 Escherichia coli SMS-3-5 6106468 YP_001739974.1 CDS EcSMS35_A0086 NC_010488.1 65385 65888 D identified by match to protein family HMM PF03400; IS1 transposase orfB 65385..65888 Escherichia coli SMS-3-5 6106501 YP_001739975.1 CDS EcSMS35_A0089 NC_010488.1 67112 67288 D identified by Glimmer3; putative; hypothetical protein 67112..67288 Escherichia coli SMS-3-5 6106544 YP_001739976.1 CDS EcSMS35_A0090 NC_010488.1 67356 67667 D identified by similarity to GB:AAF94632.1; match to protein family HMM PF01527; hypothetical protein 67356..67667 Escherichia coli SMS-3-5 6106481 YP_001739977.1 CDS EcSMS35_A0091 NC_010488.1 67680 67862 D identified by Glimmer3; putative; hypothetical protein 67680..67862 Escherichia coli SMS-3-5 6106498 YP_001739978.1 CDS EcSMS35_A0092 NC_010488.1 67787 68533 D identified by match to protein family HMM PF00665; integrase core subunit 67787..68533 Escherichia coli SMS-3-5 6106554 YP_001739979.1 CDS EcSMS35_A0093 NC_010488.1 68554 68778 R identified by Glimmer3; putative; hypothetical protein complement(68554..68778) Escherichia coli SMS-3-5 6106514 YP_001739980.1 CDS EcSMS35_A0094 NC_010488.1 68915 69085 D identified by Glimmer3; putative; hypothetical protein 68915..69085 Escherichia coli SMS-3-5 6106533 YP_001739981.1 CDS repA NC_010488.1 69078 70055 D identified by similarity to SP:Q57154; match to protein family HMM PF01051; repFIB replication protein A 69078..70055 Escherichia coli SMS-3-5 6106469 YP_001739982.1 CDS EcSMS35_A0096 NC_010488.1 70340 71080 R identified by match to protein family HMM PF00589; site-specific recombinase complement(70340..71080) Escherichia coli SMS-3-5 6106529 YP_001739983.1 CDS EcSMS35_A0097 NC_010488.1 71763 72671 R identified by match to protein family HMM PF07395; Mig-14 family protein complement(71763..72671) Escherichia coli SMS-3-5 6106565 YP_001739984.1 CDS hlyF NC_010488.1 72734 73843 R identified by similarity to GB:AAG43374.1; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; hemolysin F complement(72734..73843) Escherichia coli SMS-3-5 6106558 YP_001739985.1 CDS ompT NC_010488.1 74276 75229 R outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease complement(74276..75229) Escherichia coli SMS-3-5 6106504 YP_001739986.1 CDS EcSMS35_A0100 NC_010488.1 75333 75722 D identified by Glimmer3; putative; hypothetical protein 75333..75722 Escherichia coli SMS-3-5 6106626 YP_001739987.1 CDS EcSMS35_A0101 NC_010488.1 76844 77170 D identified by match to protein family HMM PF01527; IS629 transposase orfA 76844..77170 Escherichia coli SMS-3-5 6106515 YP_001739988.1 CDS EcSMS35_A0102 NC_010488.1 77170 78057 D identified by match to protein family HMM PF00665; IS629 transposase orfB 77170..78057 Escherichia coli SMS-3-5 6106472 YP_001739989.1 CDS EcSMS35_A0103 NC_010488.1 78501 78713 D identified by similarity to GB:ABB64642.1; IS1 transposase orfA 78501..78713 Escherichia coli SMS-3-5 6106463 YP_001739990.1 CDS EcSMS35_A0104 NC_010488.1 78724 79227 D identified by match to protein family HMM PF03400; IS1 transposase orfB 78724..79227 Escherichia coli SMS-3-5 6106464 YP_001739991.1 CDS EcSMS35_A0105 NC_010488.1 80119 80400 R identified by Glimmer3; putative; hypothetical protein complement(80119..80400) Escherichia coli SMS-3-5 6106555 YP_001739992.1 CDS EcSMS35_A0108 NC_010488.1 80919 81329 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 80919..81329 Escherichia coli SMS-3-5 6106523 YP_001739993.1 CDS EcSMS35_A0110 NC_010488.1 81287 82192 D identified by match to protein family HMM PF00665; IS2 transposase orfB 81287..82192 Escherichia coli SMS-3-5 6106475 YP_001739994.1 CDS cma NC_010488.1 82865 83680 D identified by similarity to SP:P05820; colicin-M 82865..83680 Escherichia coli SMS-3-5 6106457 YP_001739995.1 CDS cmi NC_010488.1 83730 84155 R identified by similarity to SP:P18002; colicin-M immunity protein Cmi complement(83730..84155) Escherichia coli SMS-3-5 6106600 YP_001739996.1 CDS resD NC_010488.1 84261 85037 R identified by similarity to SP:P18021; match to protein family HMM PF00589; resolvase complement(84261..85037) Escherichia coli SMS-3-5 6106534 YP_001739997.1 CDS EcSMS35_A0114 NC_010488.1 85049 85348 R identified by Glimmer3; putative; hypothetical protein complement(85049..85348) Escherichia coli SMS-3-5 6106531 YP_001739998.1 CDS EcSMS35_A0115 NC_010488.1 85355 86077 D identified by match to protein family HMM PF00665; IS26 transposase 85355..86077 Escherichia coli SMS-3-5 6106628 YP_001739999.1 CDS EcSMS35_A0116 NC_010488.1 86840 87562 D identified by match to protein family HMM PF00665; IS26 transposase 86840..87562 Escherichia coli SMS-3-5 6106588 YP_001740000.1 CDS cmlA NC_010488.1 87706 88347 R identified by match to protein family HMM PF00302; chloramphenicol acetyltransferase 2 complement(87706..88347) Escherichia coli SMS-3-5 6106497 YP_001740001.1 CDS EcSMS35_A0118 NC_010488.1 88497 88997 R identified by similarity to GB:ABG56838.1; hypothetical protein complement(88497..88997) Escherichia coli SMS-3-5 6106525 YP_001740002.1 CDS EcSMS35_A0119 NC_010488.1 89059 89781 D identified by match to protein family HMM PF00665; IS26 transposase 89059..89781 Escherichia coli SMS-3-5 6106474 YP_001740003.1 CDS EcSMS35_A0120 NC_010488.1 90229 91242 R identified by match to protein family HMM PF00589; match to protein family HMM PF02899; match to protein family HMM TIGR02249; integrase/recombinase complement(90229..91242) Escherichia coli SMS-3-5 6106580 YP_001740004.1 CDS dhfrV NC_010488.1 91389 91871 D identified by similarity to SP:P11731; match to protein family HMM PF00186; dihydrofolate reductase type 5 91389..91871 Escherichia coli SMS-3-5 6106542 YP_001740005.1 CDS EcSMS35_A0122 NC_010488.1 91923 92645 D identified by match to protein family HMM PF00665; IS26 transposase 91923..92645 Escherichia coli SMS-3-5 6106561 YP_001740006.1 CDS EcSMS35_A0124 NC_010488.1 93016 95982 D identified by match to protein family HMM PF01526; Tn3 family transposase 93016..95982 Escherichia coli SMS-3-5 6106562 YP_001740007.1 CDS EcSMS35_A0125 NC_010488.1 96061 97065 D identified by match to protein family HMM PF02371; IS5075 transposase 96061..97065 Escherichia coli SMS-3-5 6106566 YP_001740008.1 CDS EcSMS35_A0126 NC_010488.1 97562 97744 D identified by similarity to GB:BAF38229.1; hypothetical protein 97562..97744 Escherichia coli SMS-3-5 6106454 YP_001740009.1 CDS sul2 NC_010488.1 97753 98568 D identified by similarity to SP:P0AC11; match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase type-2 97753..98568 Escherichia coli SMS-3-5 6106465 YP_001740010.1 CDS strA NC_010488.1 98629 99432 D identified by match to protein family HMM PF01636; aminoglycoside resistance protein A 98629..99432 Escherichia coli SMS-3-5 6106570 YP_001740011.1 CDS strB NC_010488.1 99438 100268 D identified by match to protein family HMM PF04655; aminoglycoside resistance protein B 99438..100268 Escherichia coli SMS-3-5 6106543 YP_001740012.1 CDS blaT NC_010488.1 100499 101359 R identified by similarity to SP:P62593; match to protein family HMM PF00144; beta-lactamase TEM complement(100499..101359) Escherichia coli SMS-3-5 6106593 YP_001740013.1 CDS EcSMS35_A0132 NC_010488.1 101868 102590 D identified by match to protein family HMM PF00665; IS26 transposase 101868..102590 Escherichia coli SMS-3-5 6106507 YP_001740014.1 CDS sat NC_010488.1 102959 104038 D identified by match to protein family HMM PF00561; streptothricin acetyltransferase Sat-1 102959..104038 Escherichia coli SMS-3-5 6106506 YP_001740015.1 CDS EcSMS35_A0134 NC_010488.1 104134 104742 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490; HAD family hydrolase 104134..104742 Escherichia coli SMS-3-5 6106556 YP_001740016.1 CDS aadA NC_010488.1 104788 105591 D streptomycin 3'-adenyltransferase; aminoglycoside resistance protein 104788..105591 Escherichia coli SMS-3-5 6106452 YP_001740017.1 CDS EcSMS35_A0136 NC_010488.1 105733 106455 R identified by match to protein family HMM PF00665; IS26 transposase complement(105733..106455) Escherichia coli SMS-3-5 6106545 YP_001740018.1 CDS EcSMS35_A0138 NC_010488.1 107266 108165 R identified by similarity to GB:AAR07693.1; hypothetical protein complement(107266..108165) Escherichia coli SMS-3-5 6106568 YP_001740019.1 CDS EcSMS35_A0139 NC_010488.1 108155 108445 R identified by similarity to GB:AAR07694.1; hypothetical protein complement(108155..108445) Escherichia coli SMS-3-5 6106493 YP_001740020.1 CDS vagC NC_010488.1 108741 108971 D identified by similarity to SP:Q05459; match to protein family HMM PF04014; plasmid maintenance protein VagC 108741..108971 Escherichia coli SMS-3-5 6106521 YP_001740021.1 CDS vagD NC_010488.1 108968 109384 D identified by match to protein family HMM PF01850; plasmid maintenance protein VagD 108968..109384 Escherichia coli SMS-3-5 6106455 YP_001740022.1 CDS EcSMS35_A0142 NC_010488.1 109546 111684 R identified by similarity to GB:BAB91601; hypothetical protein complement(109546..111684) Escherichia coli SMS-3-5 6106471 YP_001740023.1 CDS EcSMS35_A0143 NC_010488.1 112038 112295 D identified by similarity to GB:BAB91600; hypothetical protein 112038..112295 Escherichia coli SMS-3-5 6106575 YP_001740024.1 CDS EcSMS35_A0144 NC_010488.1 112295 112885 D identified by similarity to GB:BAB91599; hypothetical protein 112295..112885 Escherichia coli SMS-3-5 6106510 YP_001740025.1 CDS EcSMS35_A0145 NC_010488.1 113148 114704 D identified by similarity to GB:BAB91598; hypothetical protein 113148..114704 Escherichia coli SMS-3-5 6106459 YP_001740026.1 CDS EcSMS35_A0146 NC_010488.1 114896 115513 D identified by similarity to GB:BAB91597; hypothetical protein 114896..115513 Escherichia coli SMS-3-5 6106585 YP_001740027.1 CDS EcSMS35_A0147 NC_010488.1 115806 116885 R identified by match to protein family HMM PF03773; putative permease complement(115806..116885) Escherichia coli SMS-3-5 6106625 YP_001740028.1 CDS EcSMS35_A0148 NC_010488.1 116990 117313 D identified by match to protein family HMM PF01022; ArsR family transcriptional regulator 116990..117313 Escherichia coli SMS-3-5 6106449 YP_001740029.1 CDS EcSMS35_A0149 NC_010488.1 117847 118569 R identified by match to protein family HMM PF00665; IS26 transposase complement(117847..118569) Escherichia coli SMS-3-5 6106597 YP_001740030.1 CDS EcSMS35_A0150 NC_010488.1 118542 119474 D identified by match to protein family HMM PF01526; Tn1721 transposase 118542..119474 Escherichia coli SMS-3-5 6106524 YP_001740031.1 CDS EcSMS35_A0151 NC_010488.1 119532 119774 D identified by similarity to GB:AAS76290; hypothetical protein 119532..119774 Escherichia coli SMS-3-5 6106582 YP_001740032.1 CDS tetR NC_010488.1 119806 120483 R identified by similarity to SP:P03038; match to protein family HMM PF00440; match to protein family HMM PF02909; tetracycline repressor protein, class A complement(119806..120483) Escherichia coli SMS-3-5 6106470 YP_001740033.1 CDS tetA NC_010488.1 120487 121761 D identified by similarity to SP:P02982; match to protein family HMM PF07690; match to protein family HMM TIGR00880; tetracycline resistance protein, class A 120487..121761 Escherichia coli SMS-3-5 6106627 YP_001740034.1 CDS EcSMS35_A0154 NC_010488.1 121793 122677 R identified by match to protein family HMM PF00892; drug/metabolite transporter complement(121793..122677) Escherichia coli SMS-3-5 6106532 YP_001740035.1 CDS EcSMS35_A0155 NC_010488.1 122815 123222 R identified by similarity to GB:AAS76286.1; hypothetical protein complement(122815..123222) Escherichia coli SMS-3-5 6106567 YP_001740036.1 CDS EcSMS35_A0156 NC_010488.1 124842 125564 R identified by match to protein family HMM PF00665; IS26 transposase complement(124842..125564) Escherichia coli SMS-3-5 6106601 YP_001740037.1 CDS EcSMS35_A0159 NC_010488.1 126086 126901 R identified by similarity to SP:P00551; match to protein family HMM PF01636; aminoglycoside 3'-phosphotransferase complement(126086..126901) Escherichia coli SMS-3-5 6106584 YP_001740038.1 CDS EcSMS35_A0160 NC_010488.1 127034 127756 D identified by match to protein family HMM PF00665; IS26 transposase 127034..127756 Escherichia coli SMS-3-5 6106547 YP_001740039.1 CDS EcSMS35_A0163 NC_010488.1 128635 128847 R identified by similarity to GB:ABB64642.1; IS1 transposase orfA complement(128635..128847) Escherichia coli SMS-3-5 6106460 YP_001740040.1 CDS pemK NC_010488.1 129067 129432 R identified by similarity to SP:P13976; match to protein family HMM PF02452; stable plasmid inheritance protein PemK complement(129067..129432) Escherichia coli SMS-3-5 6106502 YP_001740041.1 CDS pemI NC_010488.1 129401 129658 R identified by similarity to SP:P13975; match to protein family HMM PF04014; stable plasmid inheritance protein PemI complement(129401..129658) Escherichia coli SMS-3-5 6106517 YP_001740042.1 CDS EcSMS35_A0166 NC_010488.1 129751 130404 R identified by match to protein family HMM PF02517; CAAX amino protease complement(129751..130404) Escherichia coli SMS-3-5 6106537 YP_001742118.1 CDS thrA NC_010498.1 336 2798 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 336..2798 Escherichia coli SMS-3-5 6142593 YP_001742119.1 CDS thrB NC_010498.1 2800 3732 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2800..3732 Escherichia coli SMS-3-5 6143317 YP_001742120.1 CDS thrC NC_010498.1 3733 5019 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3733..5019 Escherichia coli SMS-3-5 6146078 YP_001742121.1 CDS EcSMS35_0004 NC_010498.1 5309 5557 R identified by Glimmer3; putative; hypothetical protein complement(5309..5557) Escherichia coli SMS-3-5 6146467 YP_001742122.1 CDS EcSMS35_0005 NC_010498.1 5569 6345 R identified by match to protein family HMM PF03883; hypothetical protein complement(5569..6345) Escherichia coli SMS-3-5 6144732 YP_001742123.1 CDS agcS NC_010498.1 6415 7845 R identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; amino acid carrier protein complement(6415..7845) Escherichia coli SMS-3-5 6146281 YP_001742124.1 CDS tal2 NC_010498.1 8061 9077 D identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874; transaldolase B 8061..9077 Escherichia coli SMS-3-5 6144239 YP_001742125.1 CDS mogA NC_010498.1 9192 9779 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9192..9779 Escherichia coli SMS-3-5 6145817 YP_001742126.1 CDS EcSMS35_0009 NC_010498.1 9814 10380 R identified by match to protein family HMM PF01184; hypothetical protein complement(9814..10380) Escherichia coli SMS-3-5 6147415 YP_001742127.1 CDS EcSMS35_0010 NC_010498.1 10529 11242 R identified by match to protein family HMM PF03667; hypothetical protein complement(10529..11242) Escherichia coli SMS-3-5 6144778 YP_001742128.1 CDS EcSMS35_0011 NC_010498.1 11267 11671 R hypothetical protein complement(11267..11671) Escherichia coli SMS-3-5 6142683 YP_001742129.1 CDS dnaK NC_010498.1 12047 13963 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12047..13963 Escherichia coli SMS-3-5 6144644 YP_001742130.1 CDS dnaJ NC_010498.1 14052 15182 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 14052..15182 Escherichia coli SMS-3-5 6146232 YP_001742131.1 CDS EcSMS35_0014 NC_010498.1 16050 16811 D identified by match to protein family HMM PF07135; hypothetical protein 16050..16811 Escherichia coli SMS-3-5 6143168 YP_001742132.1 CDS EcSMS35_0015 NC_010498.1 16831 18324 D identified by match to protein family HMM PF00884; sulfatase 16831..18324 Escherichia coli SMS-3-5 6146080 YP_001742133.1 CDS EcSMS35_0016 NC_010498.1 18454 19698 D identified by similarity to GB:AAX63939.1; hypothetical protein 18454..19698 Escherichia coli SMS-3-5 6142614 YP_001742134.1 CDS nhaA NC_010498.1 19950 21116 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 19950..21116 Escherichia coli SMS-3-5 6146923 YP_001742135.1 CDS nhaR NC_010498.1 21176 22081 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 21176..22081 Escherichia coli SMS-3-5 6143420 YP_001742136.1 CDS EcSMS35_0019 NC_010498.1 22139 24178 R identified by match to protein family HMM PF01055; glycosyl hydrolase family protein complement(22139..24178) Escherichia coli SMS-3-5 6145809 YP_001742137.1 CDS xlyP NC_010498.1 24218 25591 R identified by similarity to SP:P96792; match to protein family HMM PF07690; match to protein family HMM TIGR00792; xylose-proton symporter complement(24218..25591) Escherichia coli SMS-3-5 6145471 YP_001742138.1 CDS EcSMS35_0021 NC_010498.1 25804 25926 D identified by Glimmer3; putative; hypothetical protein 25804..25926 Escherichia coli SMS-3-5 6144787 YP_001742139.1 CDS rpsT NC_010498.1 25999 26262 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(25999..26262) Escherichia coli SMS-3-5 6144261 YP_001742140.1 CDS ribF NC_010498.1 26591 27532 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 26591..27532 Escherichia coli SMS-3-5 6142631 YP_001742141.1 CDS ileS NC_010498.1 27575 30391 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 27575..30391 Escherichia coli SMS-3-5 6144335 YP_001742142.1 CDS lspA NC_010498.1 30391 30885 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 30391..30885 Escherichia coli SMS-3-5 6143321 YP_001742143.1 CDS fkpB NC_010498.1 30973 31422 D identified by match to protein family HMM PF00254; FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase 30973..31422 Escherichia coli SMS-3-5 6143886 YP_001742144.1 CDS ispH NC_010498.1 31424 32374 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 31424..32374 Escherichia coli SMS-3-5 6146607 YP_001742145.1 CDS rihC NC_010498.1 32440 33354 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 32440..33354 Escherichia coli SMS-3-5 6143577 YP_001742146.1 CDS dapB NC_010498.1 33521 34342 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 33521..34342 Escherichia coli SMS-3-5 6145167 YP_001742147.1 CDS EcSMS35_0030 NC_010498.1 34354 34536 R identified by Glimmer3; putative; hypothetical protein complement(34354..34536) Escherichia coli SMS-3-5 6147084 YP_001742148.1 CDS EcSMS35_0031 NC_010498.1 34621 34758 D identified by Glimmer3; putative; hypothetical protein 34621..34758 Escherichia coli SMS-3-5 6143866 YP_001742149.1 CDS carA NC_010498.1 34771 35946 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 34771..35946 Escherichia coli SMS-3-5 6144305 YP_001742150.1 CDS carB NC_010498.1 35964 39185 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 35964..39185 Escherichia coli SMS-3-5 6142597 YP_001742151.1 CDS EcSMS35_0034 NC_010498.1 39193 39411 R identified by Glimmer3; putative; hypothetical protein complement(39193..39411) Escherichia coli SMS-3-5 6144467 YP_001742152.1 CDS caiF NC_010498.1 39446 39841 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 39446..39841 Escherichia coli SMS-3-5 6147004 YP_001742153.1 CDS caiE NC_010498.1 39960 40550 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(39960..40550) Escherichia coli SMS-3-5 6144286 YP_001742154.1 CDS caiD NC_010498.1 40556 41341 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(40556..41341) Escherichia coli SMS-3-5 6147393 YP_001742155.1 CDS caiC NC_010498.1 41450 43003 R identified by match to protein family HMM PF00501; putative crotonobetaine/carnitine-CoA ligase complement(41450..43003) Escherichia coli SMS-3-5 6143120 YP_001742156.1 CDS caiB NC_010498.1 43077 44294 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(43077..44294) Escherichia coli SMS-3-5 6145771 YP_001742157.1 CDS caiA NC_010498.1 44423 45565 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(44423..45565) Escherichia coli SMS-3-5 6146162 YP_001742158.1 CDS caiT NC_010498.1 45596 47110 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(45596..47110) Escherichia coli SMS-3-5 6144631 YP_001742159.1 CDS EcSMS35_0042 NC_010498.1 47226 47375 D identified by Glimmer3; putative; hypothetical protein 47226..47375 Escherichia coli SMS-3-5 6145132 YP_001742160.1 CDS fixA NC_010498.1 47583 48353 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 47583..48353 Escherichia coli SMS-3-5 6142730 YP_001742161.1 CDS fixB NC_010498.1 48368 49309 D involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 48368..49309 Escherichia coli SMS-3-5 6143569 YP_001742162.1 CDS fixC NC_010498.1 49360 50646 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase FixC 49360..50646 Escherichia coli SMS-3-5 6146602 YP_001742163.1 CDS fixX NC_010498.1 50643 50930 D ferredoxin FixX-like protein 50643..50930 Escherichia coli SMS-3-5 6147147 YP_001742164.1 CDS EcSMS35_0047 NC_010498.1 50989 52320 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 50989..52320 Escherichia coli SMS-3-5 6145129 YP_001742165.1 CDS kefF NC_010498.1 52428 52958 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 52428..52958 Escherichia coli SMS-3-5 6145772 YP_001742166.1 CDS kefC NC_010498.1 52951 54813 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 52951..54813 Escherichia coli SMS-3-5 6143839 YP_001742167.1 CDS folA NC_010498.1 54894 55484 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 54894..55484 Escherichia coli SMS-3-5 6144196 YP_001742168.1 CDS EcSMS35_0051 NC_010498.1 55801 56250 R identified by Glimmer3; putative; hypothetical protein complement(55801..56250) Escherichia coli SMS-3-5 6144916 YP_001742169.1 CDS EcSMS35_0052 NC_010498.1 56286 56885 R hypothetical protein complement(56286..56885) Escherichia coli SMS-3-5 6142698 YP_001742170.1 CDS apaH NC_010498.1 56910 57758 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(56910..57758) Escherichia coli SMS-3-5 6143405 YP_001742171.1 CDS apaG NC_010498.1 57765 58142 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(57765..58142) Escherichia coli SMS-3-5 6145317 YP_001742172.1 CDS ksgA NC_010498.1 58145 58966 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(58145..58966) Escherichia coli SMS-3-5 6146066 YP_001742173.1 CDS pdxA NC_010498.1 58963 59952 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(58963..59952) Escherichia coli SMS-3-5 6147478 YP_001742174.1 CDS surA NC_010498.1 59952 61238 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(59952..61238) Escherichia coli SMS-3-5 6143017 YP_001742175.1 CDS imp NC_010498.1 61291 63648 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(61291..63648) Escherichia coli SMS-3-5 6146361 YP_001742176.1 CDS djlA NC_010498.1 63903 64718 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 63903..64718 Escherichia coli SMS-3-5 6145468 YP_001742177.1 CDS EcSMS35_0060 NC_010498.1 64836 65495 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(64836..65495) Escherichia coli SMS-3-5 6145979 YP_001742178.1 CDS rapA NC_010498.1 65507 68413 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(65507..68413) Escherichia coli SMS-3-5 6144155 YP_001742179.1 CDS polB NC_010498.1 68577 70928 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(68577..70928) Escherichia coli SMS-3-5 6144677 YP_001742180.1 CDS araD NC_010498.1 71003 71698 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(71003..71698) Escherichia coli SMS-3-5 6143158 YP_001742181.1 CDS araA NC_010498.1 71898 73400 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(71898..73400) Escherichia coli SMS-3-5 6147409 YP_001742182.1 CDS araB NC_010498.1 73411 75111 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(73411..75111) Escherichia coli SMS-3-5 6147000 YP_001742183.1 CDS araC NC_010498.1 75450 76295 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 75450..76295 Escherichia coli SMS-3-5 6143191 YP_001742184.1 CDS EcSMS35_0067 NC_010498.1 76809 77657 D identified by similarity to GB:CAG77221.1; hypothetical protein 76809..77657 Escherichia coli SMS-3-5 6142995 YP_001742185.1 CDS EcSMS35_0068 NC_010498.1 77664 78086 D identified by similarity to GB:AAG02753.1; hypothetical protein 77664..78086 Escherichia coli SMS-3-5 6143810 YP_001742186.1 CDS EcSMS35_0069 NC_010498.1 78241 79005 D identified by match to protein family HMM PF09335; hypothetical protein 78241..79005 Escherichia coli SMS-3-5 6145829 YP_001742187.1 CDS thiQ NC_010498.1 79075 79773 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(79075..79773) Escherichia coli SMS-3-5 6145331 YP_001742188.1 CDS thiP NC_010498.1 79757 81367 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(79757..81367) Escherichia coli SMS-3-5 6145002 YP_001742189.1 CDS tbpA NC_010498.1 81343 82326 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(81343..82326) Escherichia coli SMS-3-5 6146880 YP_001742190.1 CDS EcSMS35_0073 NC_010498.1 82784 83266 D identified by similarity to GB:ABB60319.1; hypothetical protein 82784..83266 Escherichia coli SMS-3-5 6146656 YP_001742191.1 CDS sgrR NC_010498.1 83496 85154 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(83496..85154) Escherichia coli SMS-3-5 6145976 YP_001742192.1 CDS EcSMS35_0075 NC_010498.1 85243 85374 D identified by similarity to GB:AAX64010.1; hypothetical protein 85243..85374 Escherichia coli SMS-3-5 6145773 YP_001742193.1 CDS leuD NC_010498.1 85482 86087 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(85482..86087) Escherichia coli SMS-3-5 6144971 YP_001742194.1 CDS leuC NC_010498.1 86098 87498 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(86098..87498) Escherichia coli SMS-3-5 6147182 YP_001742195.1 CDS leuB NC_010498.1 87501 88592 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(87501..88592) Escherichia coli SMS-3-5 6146489 YP_001742196.1 CDS leuA NC_010498.1 88592 90163 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(88592..90163) Escherichia coli SMS-3-5 6143537 YP_001742197.1 CDS EcSMS35_0080 NC_010498.1 90380 90511 R identified by Glimmer3; putative; hypothetical protein complement(90380..90511) Escherichia coli SMS-3-5 6142863 YP_001742198.1 CDS leuO NC_010498.1 91001 91945 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 91001..91945 Escherichia coli SMS-3-5 6144420 YP_001742199.1 CDS EcSMS35_0082 NC_010498.1 91981 92103 R identified by Glimmer3; putative; hypothetical protein complement(91981..92103) Escherichia coli SMS-3-5 6144003 YP_001742200.1 CDS ilvI NC_010498.1 92173 93987 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 92173..93987 Escherichia coli SMS-3-5 6145702 YP_001742201.1 CDS ilvH NC_010498.1 93960 94481 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 93960..94481 Escherichia coli SMS-3-5 6147258 YP_001742202.1 CDS fruR NC_010498.1 94661 95665 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 94661..95665 Escherichia coli SMS-3-5 6147209 YP_001742203.1 CDS mraZ NC_010498.1 96267 96725 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 96267..96725 Escherichia coli SMS-3-5 6142788 YP_001742204.1 CDS mraW NC_010498.1 96727 97668 D identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 96727..97668 Escherichia coli SMS-3-5 6143316 YP_001742205.1 CDS ftsL NC_010498.1 97665 98030 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 97665..98030 Escherichia coli SMS-3-5 6143869 YP_001742206.1 CDS ftsI NC_010498.1 98046 99812 D identified by match to protein family HMM PF00905; match to protein family HMM PF03717; peptidoglycan synthetase FtsI 98046..99812 Escherichia coli SMS-3-5 6144983 YP_001742207.1 CDS murE NC_010498.1 99799 101286 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 99799..101286 Escherichia coli SMS-3-5 6145782 YP_001742208.1 CDS murF NC_010498.1 101283 102641 D identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 101283..102641 Escherichia coli SMS-3-5 6146512 YP_001742209.1 CDS mraY NC_010498.1 102635 103717 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 102635..103717 Escherichia coli SMS-3-5 6147045 YP_001742210.1 CDS murD NC_010498.1 103720 105036 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 103720..105036 Escherichia coli SMS-3-5 6143343 YP_001742211.1 CDS ftsW NC_010498.1 105036 106280 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 105036..106280 Escherichia coli SMS-3-5 6145892 YP_001742212.1 CDS murG NC_010498.1 106277 107344 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 106277..107344 Escherichia coli SMS-3-5 6146870 YP_001742213.1 CDS murC NC_010498.1 107398 108873 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 107398..108873 Escherichia coli SMS-3-5 6142605 YP_001742214.1 CDS ddl NC_010498.1 108866 109786 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 108866..109786 Escherichia coli SMS-3-5 6142986 YP_001742215.1 CDS ftsQ NC_010498.1 109788 110618 D involved in septum formation; cell division protein FtsQ 109788..110618 Escherichia coli SMS-3-5 6143131 YP_001742216.1 CDS ftsA NC_010498.1 110615 111877 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 110615..111877 Escherichia coli SMS-3-5 6144236 YP_001742217.1 CDS ftsZ NC_010498.1 111939 113090 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 111939..113090 Escherichia coli SMS-3-5 6144656 YP_001742218.1 CDS lpxC NC_010498.1 113191 114108 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 113191..114108 Escherichia coli SMS-3-5 6145349 YP_001742219.1 CDS secM NC_010498.1 114264 114851 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 114264..114851 Escherichia coli SMS-3-5 6145359 YP_001742220.1 CDS secA NC_010498.1 114913 117618 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 114913..117618 Escherichia coli SMS-3-5 6146317 YP_001742221.1 CDS mutT NC_010498.1 117678 118076 D identified by match to protein family HMM PF00293; match to protein family HMM TIGR00586; nucleoside triphosphate pyrophosphohydrolase 117678..118076 Escherichia coli SMS-3-5 6144967 YP_001742222.1 CDS EcSMS35_0105 NC_010498.1 118165 118362 R identified by match to protein family HMM PF03884; zinc-binding protein complement(118165..118362) Escherichia coli SMS-3-5 6147020 YP_001742223.1 CDS EcSMS35_0106 NC_010498.1 118372 119115 R identified by match to protein family HMM PF07072; hypothetical protein complement(118372..119115) Escherichia coli SMS-3-5 6147232 YP_001742224.1 CDS coaE NC_010498.1 119115 119735 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(119115..119735) Escherichia coli SMS-3-5 6143130 YP_001742225.1 CDS guaC NC_010498.1 119960 121003 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 119960..121003 Escherichia coli SMS-3-5 6143417 YP_001742226.1 CDS pilC NC_010498.1 121038 122240 R identified by match to protein family HMM PF00482; type IV pilin biogenesis protein complement(121038..122240) Escherichia coli SMS-3-5 6142966 YP_001742227.1 CDS hofB NC_010498.1 122230 123615 R identified by match to protein family HMM PF00437; hypothetical protein complement(122230..123615) Escherichia coli SMS-3-5 6145896 YP_001742228.1 CDS pilA NC_010498.1 123625 124065 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; putative major pilin subunit complement(123625..124065) Escherichia coli SMS-3-5 6145287 YP_001742229.1 CDS nadC NC_010498.1 124268 125161 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(124268..125161) Escherichia coli SMS-3-5 6147011 YP_001742230.1 CDS ampD NC_010498.1 125249 125800 D identified by match to protein family HMM PF01510; N-acetyl-anhydromuranmyl-L-alanine amidase 125249..125800 Escherichia coli SMS-3-5 6146193 YP_001742231.1 CDS ampE NC_010498.1 125797 126651 D involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 125797..126651 Escherichia coli SMS-3-5 6143145 YP_001742232.1 CDS aroP NC_010498.1 126694 128064 R identified by similarity to SP:P15993; match to protein family HMM PF00324; aromatic amino acid transporter complement(126694..128064) Escherichia coli SMS-3-5 6144209 YP_001742233.1 CDS EcSMS35_0116 NC_010498.1 128593 130374 D identified by match to protein family HMM PF01844; match to protein family HMM PF05638; match to protein family HMM PF06958; match to protein family HMM TIGR03344; putative S-type colicin 128593..130374 Escherichia coli SMS-3-5 6144545 YP_001742234.1 CDS EcSMS35_0117 NC_010498.1 130377 130661 D putative colicin immunity protein 130377..130661 Escherichia coli SMS-3-5 6144940 YP_001742235.1 CDS EcSMS35_0118 NC_010498.1 130829 131068 D putative colicin 130829..131068 Escherichia coli SMS-3-5 6145931 YP_001742236.1 CDS EcSMS35_0119 NC_010498.1 131069 131359 D identified by match to protein family HMM PF01320; putative colicin immunity protein 131069..131359 Escherichia coli SMS-3-5 6147187 YP_001742237.1 CDS EcSMS35_0120 NC_010498.1 131526 131714 D putative colicin 131526..131714 Escherichia coli SMS-3-5 6145749 YP_001742238.1 CDS EcSMS35_0121 NC_010498.1 131762 132058 D identified by match to protein family HMM PF01320; putative colicin immunity protein 131762..132058 Escherichia coli SMS-3-5 6146480 YP_001742239.1 CDS pdhR NC_010498.1 132514 133278 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 132514..133278 Escherichia coli SMS-3-5 6147321 YP_001742240.1 CDS EcSMS35_0122 NC_010498.1 133275 133457 R identified by Glimmer3; putative; hypothetical protein complement(133275..133457) Escherichia coli SMS-3-5 6143832 YP_001742241.1 CDS aceE NC_010498.1 133439 136102 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 133439..136102 Escherichia coli SMS-3-5 6142768 YP_001742242.1 CDS aceF NC_010498.1 136117 138009 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 136117..138009 Escherichia coli SMS-3-5 6144791 YP_001742243.1 CDS lpdA NC_010498.1 138154 139641 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 138154..139641 Escherichia coli SMS-3-5 6144414 YP_001742244.1 CDS EcSMS35_0127 NC_010498.1 139712 141469 R identified by similarity to GB:AAZ86919.1; hypothetical protein complement(139712..141469) Escherichia coli SMS-3-5 6143926 YP_001742245.1 CDS acnB NC_010498.1 141902 144421 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 141902..144421 Escherichia coli SMS-3-5 6143392 YP_001742246.1 CDS EcSMS35_0129 NC_010498.1 144596 144958 D identified by match to protein family HMM PF06062; hypothetical protein 144596..144958 Escherichia coli SMS-3-5 6142738 YP_001742247.1 CDS speD NC_010498.1 144996 145790 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(144996..145790) Escherichia coli SMS-3-5 6147261 YP_001742248.1 CDS speE NC_010498.1 145806 146672 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(145806..146672) Escherichia coli SMS-3-5 6146827 YP_001742249.1 CDS EcSMS35_0132 NC_010498.1 146778 147125 R hypothetical protein complement(146778..147125) Escherichia coli SMS-3-5 6147459 YP_001742250.1 CDS cueO NC_010498.1 147291 148841 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 147291..148841 Escherichia coli SMS-3-5 6144781 YP_001742251.1 CDS gcd NC_010498.1 148888 151278 R identified by match to protein family HMM PF01011; match to protein family HMM TIGR03074; quinoprotein glucose dehydrogenase complement(148888..151278) Escherichia coli SMS-3-5 6146718 YP_001742252.1 CDS hpt NC_010498.1 151484 152020 D identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 151484..152020 Escherichia coli SMS-3-5 6142813 YP_001742253.1 CDS can NC_010498.1 152061 152723 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(152061..152723) Escherichia coli SMS-3-5 6144173 YP_001742254.1 CDS EcSMS35_0137 NC_010498.1 152832 153758 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 152832..153758 Escherichia coli SMS-3-5 6144852 YP_001742255.1 CDS EcSMS35_0138 NC_010498.1 153755 154525 D identified by match to protein family HMM PF01061; ABC transporter permease 153755..154525 Escherichia coli SMS-3-5 6145433 YP_001742256.1 CDS EcSMS35_0139 NC_010498.1 154630 155070 D identified by match to protein family HMM PF03610; PTS system IIA component domain-containing protein 154630..155070 Escherichia coli SMS-3-5 6143854 YP_001742257.1 CDS EcSMS35_0140 NC_010498.1 155134 156363 D identified by match to protein family HMM PF01522; polysaccharide deacetylase domain-containing protein 155134..156363 Escherichia coli SMS-3-5 6146996 YP_001742258.1 CDS panD NC_010498.1 156367 156747 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(156367..156747) Escherichia coli SMS-3-5 6144977 YP_001742259.1 CDS EcSMS35_0142 NC_010498.1 157021 157941 D yadD; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; ISNCY family transposase 157021..157941 Escherichia coli SMS-3-5 6143098 YP_001742260.1 CDS EcSMS35_0143 NC_010498.1 158010 158225 D identified by Glimmer3; putative; hypothetical protein 158010..158225 Escherichia coli SMS-3-5 6146608 YP_001742261.1 CDS panC NC_010498.1 158307 159158 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(158307..159158) Escherichia coli SMS-3-5 6145965 YP_001742262.1 CDS panB NC_010498.1 159170 159964 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(159170..159964) Escherichia coli SMS-3-5 6143937 YP_001742263.1 CDS EcSMS35_0146 NC_010498.1 160076 161347 R identified by match to protein family HMM PF00419; putative fimbrial-like adhesin protein complement(160076..161347) Escherichia coli SMS-3-5 6146655 YP_001742264.1 CDS EcSMS35_0147 NC_010498.1 161401 161997 R identified by similarity to SP:P12267; putative fimbrial protein complement(161401..161997) Escherichia coli SMS-3-5 6147047 YP_001742265.1 CDS EcSMS35_0148 NC_010498.1 162024 162629 R identified by similarity to GB:AAZ86940.1; hypothetical protein complement(162024..162629) Escherichia coli SMS-3-5 6144507 YP_001742266.1 CDS EcSMS35_0149 NC_010498.1 162644 163210 R yadM; identified by match to protein family HMM PF00419; fimbrial protein complement(162644..163210) Escherichia coli SMS-3-5 6145365 YP_001742267.1 CDS htrE NC_010498.1 163230 165830 R similar to the fimbrial usher protein PapC; putative outer membrane usher protein complement(163230..165830) Escherichia coli SMS-3-5 6143082 YP_001742268.1 CDS EcSMS35_0151 NC_010498.1 165865 166605 R identified by match to protein family HMM PF00345; match to protein family HMM PF02753; putative chaperone protein EcpD complement(165865..166605) Escherichia coli SMS-3-5 6143769 YP_001742269.1 CDS EcSMS35_0152 NC_010498.1 166703 167287 R identified by match to protein family HMM PF00419; fimbrial protein complement(166703..167287) Escherichia coli SMS-3-5 6145151 YP_001742270.1 CDS folK NC_010498.1 167658 168137 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase complement(167658..168137) Escherichia coli SMS-3-5 6145566 YP_001742271.1 CDS pcnB NC_010498.1 168134 169498 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I complement(168134..169498) Escherichia coli SMS-3-5 6144731 YP_001742272.1 CDS gluQ NC_010498.1 169591 170517 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(169591..170517) Escherichia coli SMS-3-5 6144492 YP_001742273.1 CDS dksA NC_010498.1 170554 171009 R identified by match to protein family HMM PF01258; match to protein family HMM TIGR02420; RNA polymerase-binding transcription factor complement(170554..171009) Escherichia coli SMS-3-5 6142836 YP_001742274.1 CDS sfsA NC_010498.1 171187 171891 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(171187..171891) Escherichia coli SMS-3-5 6143960 YP_001742275.1 CDS ligT NC_010498.1 171906 172436 R identified by match to protein family HMM PF02834; match to protein family HMM TIGR02258; 2'-5' RNA ligase complement(171906..172436) Escherichia coli SMS-3-5 6146445 YP_001742276.1 CDS hrpB NC_010498.1 172465 174939 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 172465..174939 Escherichia coli SMS-3-5 6143552 YP_001742277.1 CDS mrcB NC_010498.1 175033 177567 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 175033..177567 Escherichia coli SMS-3-5 6145383 YP_001742278.1 CDS EcSMS35_0161 NC_010498.1 177632 177766 R identified by Glimmer3; putative; hypothetical protein complement(177632..177766) Escherichia coli SMS-3-5 6147265 YP_001742279.1 CDS fhuA NC_010498.1 177787 180045 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 177787..180045 Escherichia coli SMS-3-5 6143743 YP_001742280.1 CDS fhuC NC_010498.1 180096 180893 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 180096..180893 Escherichia coli SMS-3-5 6145577 YP_001742281.1 CDS fhuD NC_010498.1 180893 181783 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 180893..181783 Escherichia coli SMS-3-5 6146555 YP_001742282.1 CDS fhuB NC_010498.1 181780 183762 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 181780..183762 Escherichia coli SMS-3-5 6143524 YP_001742283.1 CDS hemL NC_010498.1 183797 185077 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(183797..185077) Escherichia coli SMS-3-5 6147468 YP_001742284.1 CDS clcA NC_010498.1 185302 186723 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 185302..186723 Escherichia coli SMS-3-5 6144534 YP_001742285.1 CDS yadR NC_010498.1 186805 187149 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 186805..187149 Escherichia coli SMS-3-5 6146864 YP_001742286.1 CDS EcSMS35_0169 NC_010498.1 187196 187819 R identified by match to protein family HMM PF03458; hypothetical protein complement(187196..187819) Escherichia coli SMS-3-5 6146379 YP_001742287.1 CDS btuF NC_010498.1 187857 188657 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(187857..188657) Escherichia coli SMS-3-5 6145835 YP_001742288.1 CDS mtnN NC_010498.1 188650 189348 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(188650..189348) Escherichia coli SMS-3-5 6145219 YP_001742289.1 CDS dgt NC_010498.1 189432 190949 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 189432..190949 Escherichia coli SMS-3-5 6145559 YP_001742290.1 CDS degP NC_010498.1 191079 192503 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 191079..192503 Escherichia coli SMS-3-5 6146103 YP_001742291.1 CDS cdaR NC_010498.1 192658 193815 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 192658..193815 Escherichia coli SMS-3-5 6144567 YP_001742292.1 CDS EcSMS35_0175 NC_010498.1 193869 194255 R hypothetical protein complement(193869..194255) Escherichia coli SMS-3-5 6143879 YP_001742293.1 CDS dapD NC_010498.1 194570 195394 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(194570..195394) Escherichia coli SMS-3-5 6143235 YP_001742294.1 CDS glnD NC_010498.1 195425 198097 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(195425..198097) Escherichia coli SMS-3-5 6147085 YP_001742295.1 CDS map NC_010498.1 198159 198953 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(198159..198953) Escherichia coli SMS-3-5 6142915 YP_001742296.1 CDS rpsB NC_010498.1 199321 200046 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 199321..200046 Escherichia coli SMS-3-5 6143613 YP_001742297.1 CDS EcSMS35_0179 NC_010498.1 199998 200162 R identified by Glimmer3; putative; hypothetical protein complement(199998..200162) Escherichia coli SMS-3-5 6143809 YP_001742298.1 CDS tsf NC_010498.1 200181 201032 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 200181..201032 Escherichia coli SMS-3-5 6146113 YP_001742299.1 CDS pyrH NC_010498.1 201179 201904 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 201179..201904 Escherichia coli SMS-3-5 6145368 YP_001742300.1 CDS frr NC_010498.1 202054 202611 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 202054..202611 Escherichia coli SMS-3-5 6145866 YP_001742301.1 CDS dxr NC_010498.1 202703 203899 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 202703..203899 Escherichia coli SMS-3-5 6142607 YP_001742302.1 CDS uppS NC_010498.1 204085 204846 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 204085..204846 Escherichia coli SMS-3-5 6143147 YP_001742303.1 CDS cdsA NC_010498.1 204859 205716 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 204859..205716 Escherichia coli SMS-3-5 6145438 YP_001742304.1 CDS rseP NC_010498.1 205728 207080 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 205728..207080 Escherichia coli SMS-3-5 6146793 YP_001742305.1 CDS yaeT NC_010498.1 207110 209542 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 207110..209542 Escherichia coli SMS-3-5 6147297 YP_001742306.1 CDS skp NC_010498.1 209664 210149 D identified by match to protein family HMM PF03938; periplasmic chaperone 209664..210149 Escherichia coli SMS-3-5 6143252 YP_001742307.1 CDS lpxD NC_010498.1 210153 211178 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 210153..211178 Escherichia coli SMS-3-5 6147512 YP_001742308.1 CDS fabZ NC_010498.1 211283 211738 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 211283..211738 Escherichia coli SMS-3-5 6143259 YP_001742309.1 CDS lpxA NC_010498.1 211742 212530 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 211742..212530 Escherichia coli SMS-3-5 6144570 YP_001742310.1 CDS lpxB NC_010498.1 212530 213678 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 212530..213678 Escherichia coli SMS-3-5 6144108 YP_001742311.1 CDS rnhB NC_010498.1 213675 214271 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 213675..214271 Escherichia coli SMS-3-5 6145969 YP_001742312.1 CDS dnaE NC_010498.1 214308 217790 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 214308..217790 Escherichia coli SMS-3-5 6145063 YP_001742313.1 CDS accA NC_010498.1 217803 218762 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 217803..218762 Escherichia coli SMS-3-5 6146524 YP_001742314.1 CDS ldcC1 NC_010498.1 218861 221002 D identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; lysine decarboxylase, constitutive 218861..221002 Escherichia coli SMS-3-5 6147071 YP_001742315.1 CDS EcSMS35_0198 NC_010498.1 221059 221448 D identified by match to protein family HMM PF00903; hypothetical protein 221059..221448 Escherichia coli SMS-3-5 6142951 YP_001742316.1 CDS tilS NC_010498.1 221513 222811 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 221513..222811 Escherichia coli SMS-3-5 6143492 YP_001742317.1 CDS rof NC_010498.1 222860 223114 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(222860..223114) Escherichia coli SMS-3-5 6146924 YP_001742318.1 CDS EcSMS35_0201 NC_010498.1 223107 223307 R identified by match to protein family HMM PF06786; hypothetical protein complement(223107..223307) Escherichia coli SMS-3-5 6147179 YP_001742319.1 CDS EcSMS35_0202 NC_010498.1 223473 224018 D identified by match to protein family HMM PF07152; hypothetical protein 223473..224018 Escherichia coli SMS-3-5 6145716 YP_001742320.1 CDS EcSMS35_0203 NC_010498.1 224015 224437 D identified by match to protein family HMM PF00472; peptidyl-tRNA hydrolase domain protein 224015..224437 Escherichia coli SMS-3-5 6146273 YP_001742321.1 CDS cutF NC_010498.1 224451 225161 D identified by match to protein family HMM PF04170; lipoprotein involved with copper homeostasis and adhesion 224451..225161 Escherichia coli SMS-3-5 6144806 YP_001742322.1 CDS EcSMS35_0205 NC_010498.1 225317 226141 R hypothetical protein complement(225317..226141) Escherichia coli SMS-3-5 6145056 YP_001742323.1 CDS proS NC_010498.1 226194 227912 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(226194..227912) Escherichia coli SMS-3-5 6142892 YP_001742324.1 CDS EcSMS35_0207 NC_010498.1 228023 228730 R yaeB; identified by similarity to SP:P28634; match to protein family HMM PF01980; match to protein family HMM TIGR00104; hypothetical protein complement(228023..228730) Escherichia coli SMS-3-5 6144747 YP_001742325.1 CDS rcsF NC_010498.1 228727 229080 R outer membrane lipoprotein complement(228727..229080) Escherichia coli SMS-3-5 6143243 YP_001742326.1 CDS metQ NC_010498.1 229249 230064 R identified by match to protein family HMM PF03180; match to protein family HMM TIGR00363; DL-methionine transporter substrate-binding subunit complement(229249..230064) Escherichia coli SMS-3-5 6146443 YP_001742327.1 CDS metI NC_010498.1 230104 230757 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit complement(230104..230757) Escherichia coli SMS-3-5 6145108 YP_001742328.1 CDS metN NC_010498.1 230750 231781 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(230750..231781) Escherichia coli SMS-3-5 6142860 YP_001742329.1 CDS EcSMS35_0212 NC_010498.1 231969 232541 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 231969..232541 Escherichia coli SMS-3-5 6146069 YP_001742330.1 CDS dkgB NC_010498.1 238293 239096 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 238293..239096 Escherichia coli SMS-3-5 6143645 YP_001742331.1 CDS EcSMS35_0221 NC_010498.1 239093 240007 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(239093..240007) Escherichia coli SMS-3-5 6146092 YP_001742332.1 CDS EcSMS35_0223 NC_010498.1 240248 241048 D identified by match to protein family HMM PF03372; hypothetical protein 240248..241048 Escherichia coli SMS-3-5 6145432 YP_001742333.1 CDS EcSMS35_0224 NC_010498.1 241122 241892 D identified by match to protein family HMM PF01209; match to protein family HMM PF08241; match to protein family HMM PF08242; UbiE/COQ5 family methlytransferase 241122..241892 Escherichia coli SMS-3-5 6144092 YP_001742334.1 CDS mltD NC_010498.1 241941 243161 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(241941..243161) Escherichia coli SMS-3-5 6144705 YP_001742335.1 CDS gloB NC_010498.1 243371 244126 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(243371..244126) Escherichia coli SMS-3-5 6145442 YP_001742336.1 CDS EcSMS35_0228 NC_010498.1 244160 244882 D identified by match to protein family HMM PF08241; putative methyltransferase 244160..244882 Escherichia coli SMS-3-5 6146052 YP_001742337.1 CDS rnhA NC_010498.1 244879 245346 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(244879..245346) Escherichia coli SMS-3-5 6145015 YP_001742338.1 CDS dnaQ NC_010498.1 245402 246142 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 245402..246142 Escherichia coli SMS-3-5 6146735 YP_001742339.1 CDS EcSMS35_0231 NC_010498.1 246450 247220 R identified by match to protein family HMM PF00795; hypothetical protein complement(246450..247220) Escherichia coli SMS-3-5 6143660 YP_001742340.1 CDS EcSMS35_0232 NC_010498.1 247398 247847 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 247398..247847 Escherichia coli SMS-3-5 6146447 YP_001742341.1 CDS fadE NC_010498.1 247890 250334 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(247890..250334) Escherichia coli SMS-3-5 6146582 YP_001742342.1 CDS gmhA NC_010498.1 250574 251152 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 250574..251152 Escherichia coli SMS-3-5 6145599 YP_001742343.1 CDS EcSMS35_0236 NC_010498.1 251268 252035 D identified by match to protein family HMM PF00310; glutamine amidotransferase, class II 251268..252035 Escherichia coli SMS-3-5 6145374 YP_001742344.1 CDS EcSMS35_0235 NC_010498.1 252006 252746 R yaFK; identified by match to protein family HMM PF06104; hypothetical protein complement(252006..252746) Escherichia coli SMS-3-5 6143284 YP_001742345.1 CDS dinJ NC_010498.1 253182 253442 R identified by similarity to SP:Q47150; match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin component DinJ complement(253182..253442) Escherichia coli SMS-3-5 6145626 YP_001742346.1 CDS EcSMS35_0239 NC_010498.1 253652 254401 D identified by match to protein family HMM PF00877; NlpC/P60 family protein 253652..254401 Escherichia coli SMS-3-5 6143372 YP_001742347.1 CDS EcSMS35_0240 NC_010498.1 254577 255074 D identified by similarity to GB:AAP15822.1; match to protein family HMM PF07605; hypothetical protein 254577..255074 Escherichia coli SMS-3-5 6147482 YP_001742348.1 CDS lfhA NC_010498.1 255186 257279 R identified by similarity to GB:CAH19113.1; match to protein family HMM PF00771; lateral flagellar export/assembly protein LfhA complement(255186..257279) Escherichia coli SMS-3-5 6147287 YP_001742349.1 CDS flhB NC_010498.1 257263 258402 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(257263..258402) Escherichia coli SMS-3-5 6146118 YP_001742350.1 CDS lfiR NC_010498.1 258392 259174 R identified by similarity to GB:CAH19115.1; match to protein family HMM PF01311; match to protein family HMM TIGR01400; lateral flagellar export/assembly protein LfiR complement(258392..259174) Escherichia coli SMS-3-5 6147296 YP_001742351.1 CDS lfiQ NC_010498.1 259176 259448 R identified by similarity to GB:CAH19116.1; match to protein family HMM PF01313; lateral flagellar export/assembly protein LfiQ complement(259176..259448) Escherichia coli SMS-3-5 6143056 YP_001742352.1 CDS fliP NC_010498.1 259451 260203 R FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP complement(259451..260203) Escherichia coli SMS-3-5 6142805 YP_001742353.1 CDS lfiN NC_010498.1 260200 260571 R identified by similarity to GB:CAH19118.1; match to protein family HMM PF01052; lateral flagellar export/assembly protein LfiN complement(260200..260571) Escherichia coli SMS-3-5 6143483 YP_001742354.1 CDS lfiM NC_010498.1 260564 261415 R identified by similarity to GB:CAH19119.1; match to protein family HMM PF01052; lateral flagellar export/assembly protein LfiM complement(260564..261415) Escherichia coli SMS-3-5 6143953 YP_001742355.1 CDS lafK NC_010498.1 261788 262774 D identified by similarity to GB:CAH19120.1; match to protein family HMM PF00158; match to protein family HMM PF02954; lateral flagellar RpoN-interacting regulatory protein LafK 261788..262774 Escherichia coli SMS-3-5 6144641 YP_001742356.1 CDS lfiE NC_010498.1 262789 263130 D identified by similarity to GB:CAH19121.1; match to protein family HMM PF02049; lateral flagellar basal body component protein LfiE 262789..263130 Escherichia coli SMS-3-5 6145632 YP_001742357.1 CDS fliF NC_010498.1 263135 264781 D the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; the Vibrio parahaemolyticus protein is associated with the lateral flagella; flagellar MS-ring protein 263135..264781 Escherichia coli SMS-3-5 6146331 YP_001742358.1 CDS fliG NC_010498.1 264759 265769 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 264759..265769 Escherichia coli SMS-3-5 6146671 YP_001742359.1 CDS fliH NC_010498.1 265772 266482 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 265772..266482 Escherichia coli SMS-3-5 6147348 YP_001742360.1 CDS lfiI NC_010498.1 266475 267812 D identified by similarity to GB:CAH19125.1; match to protein family HMM PF00006; match to protein family HMM TIGR01026; match to protein family HMM TIGR03496; lateral flagellar export/assembly protein LfiI 266475..267812 Escherichia coli SMS-3-5 6146948 YP_001742361.1 CDS lfiJ NC_010498.1 267815 268249 D identified by similarity to GB:CAH19126.1; match to protein family HMM TIGR02473; lateral flagellar export/assembly protein LfiJ 267815..268249 Escherichia coli SMS-3-5 6146297 YP_001742362.1 CDS EcSMS35_0255 NC_010498.1 268252 268647 D identified by similarity to GB:CAH19127.1; match to protein family HMM PF01467; match to protein family HMM PF06574; match to protein family HMM TIGR00125; cytidyltransferase-like protein 268252..268647 Escherichia coli SMS-3-5 6143977 YP_001742363.1 CDS EcSMS35_0256 NC_010498.1 268659 268964 R identified by Glimmer3; putative; hypothetical protein complement(268659..268964) Escherichia coli SMS-3-5 6145804 YP_001742364.1 CDS EcSMS35_0257 NC_010498.1 269191 270012 R identified by Glimmer3; putative; hypothetical protein complement(269191..270012) Escherichia coli SMS-3-5 6142795 YP_001742365.1 CDS EcSMS35_0258 NC_010498.1 270338 272782 R identified by similarity to GB:CAH19128.1; match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(270338..272782) Escherichia coli SMS-3-5 6144801 YP_001742366.1 CDS lafV NC_010498.1 272961 273890 R identified by similarity to GB:CAH19129.1; lateral flagellar associated protein LafV complement(272961..273890) Escherichia coli SMS-3-5 6144439 YP_001742367.1 CDS lfgN NC_010498.1 274018 274446 R identified by similarity to GB:CAH19130.1; lateral flagellar chaperone protein LfgN complement(274018..274446) Escherichia coli SMS-3-5 6142632 YP_001742368.1 CDS lfgM NC_010498.1 274459 274737 R identified by similarity to GB:CAH19131.1; match to protein family HMM PF04316; lateral flagellar anti-sigma factor 28 protein LfgM complement(274459..274737) Escherichia coli SMS-3-5 6143159 YP_001742369.1 CDS lfgA NC_010498.1 274817 275554 R identified by similarity to GB:CAH19132.1; match to protein family HMM PF08666; match to protein family HMM TIGR03170; lateral flagellar P-ring addition protein LfgA complement(274817..275554) Escherichia coli SMS-3-5 6147077 YP_001742370.1 CDS lfgB NC_010498.1 275636 275971 D identified by similarity to GB:CAH19133.1; match to protein family HMM TIGR01396; lateral flagellar rod protein LfgB 275636..275971 Escherichia coli SMS-3-5 6146673 YP_001742371.1 CDS flgC NC_010498.1 275974 276405 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the lateral flagella; flagellar basal body rod protein FlgC 275974..276405 Escherichia coli SMS-3-5 6145476 YP_001742372.1 CDS lfgD NC_010498.1 276405 277118 D identified by similarity to GB:CAH19135.1; match to protein family HMM PF03963; lateral flagellar rod protein LfgD 276405..277118 Escherichia coli SMS-3-5 6147224 YP_001742373.1 CDS lfgE NC_010498.1 277141 278343 D identified by similarity to GB:CAH19136.1; match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM PF07559; lateral flagellar hook protein LfgE 277141..278343 Escherichia coli SMS-3-5 6144018 YP_001742374.1 CDS flgF NC_010498.1 278343 279080 D FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 278343..279080 Escherichia coli SMS-3-5 6145573 YP_001742375.1 CDS flgG NC_010498.1 279159 279944 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 279159..279944 Escherichia coli SMS-3-5 6144385 YP_001742376.1 CDS flgH NC_010498.1 280027 280692 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; the Yersinia have 2 copies of flgH; flagellar basal body L-ring protein 280027..280692 Escherichia coli SMS-3-5 6144752 YP_001742377.1 CDS flgI NC_010498.1 280692 281807 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 280692..281807 Escherichia coli SMS-3-5 6146668 YP_001742378.1 CDS lfgJ NC_010498.1 281807 282106 D identified by similarity to GB:CAH19141.1; lateral flagellar peptidoglycan hydrolase LfgJ 281807..282106 Escherichia coli SMS-3-5 6143296 YP_001742379.1 CDS lfgK NC_010498.1 282527 283903 D identified by similarity to GB:CAH19142.1; match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR02492; lateral flagellar hook associated protein 1 282527..283903 Escherichia coli SMS-3-5 6143853 YP_001742380.1 CDS lfgL NC_010498.1 283918 284847 D identified by similarity to GB:CAH19143.1; match to protein family HMM PF00669; match to protein family HMM TIGR02550; lateral flagellar hook associated protein 3 283918..284847 Escherichia coli SMS-3-5 6144429 YP_001742381.1 CDS lafW NC_010498.1 284864 285841 D identified by similarity to GB:CAH19144.1; lateral flagellar hook associated protein LafW 284864..285841 Escherichia coli SMS-3-5 6145738 YP_001742382.1 CDS lafZ NC_010498.1 285900 286793 R identified by similarity to GB:CAH19147.1; match to protein family HMM PF00486; lateral flagellar transmembrane regulator LafZ complement(285900..286793) Escherichia coli SMS-3-5 6146164 YP_001742383.1 CDS lafA NC_010498.1 287229 288143 D identified by similarity to GB:CAH19148.1; match to protein family HMM PF00669; match to protein family HMM PF00700; lateral flagellar flagellin LafA 287229..288143 Escherichia coli SMS-3-5 6147050 YP_001742384.1 CDS lafB NC_010498.1 288349 289665 D identified by similarity to GB:CAH19149.1; match to protein family HMM PF02465; match to protein family HMM PF07195; lateral flagellar hook associated protein 2 288349..289665 Escherichia coli SMS-3-5 6142780 YP_001742385.1 CDS lafC NC_010498.1 289688 290080 D identified by similarity to GB:CAH19150.1; match to protein family HMM PF02561; match to protein family HMM TIGR00208; lateral flagellar chaperone protein LafC 289688..290080 Escherichia coli SMS-3-5 6144820 YP_001742386.1 CDS lafD NC_010498.1 290085 290396 D identified by similarity to GB:CAH19151.1; lateral flagellar chaperone protein LafD 290085..290396 Escherichia coli SMS-3-5 6145018 YP_001742387.1 CDS lafE NC_010498.1 290393 291454 D identified by similarity to GB:CAH19152.1; match to protein family HMM PF02120; lateral flagellar hook length control protein LafE 290393..291454 Escherichia coli SMS-3-5 6145868 YP_001742388.1 CDS lafF NC_010498.1 291462 291929 D identified by similarity to GB:CAH19153.1; match to protein family HMM PF03748; lateral flagellar basal body-associated protein LafF 291462..291929 Escherichia coli SMS-3-5 6146709 YP_001742389.1 CDS lafS NC_010498.1 291949 292668 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 291949..292668 Escherichia coli SMS-3-5 6147138 YP_001742390.1 CDS lafT NC_010498.1 292681 293544 D With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 292681..293544 Escherichia coli SMS-3-5 6147126 YP_001742391.1 CDS lafU NC_010498.1 293547 294470 D identified by similarity to GB:CAH19156.1; match to protein family HMM PF00691; hypothetical protein 293547..294470 Escherichia coli SMS-3-5 6145229 YP_001742392.1 CDS dinB NC_010498.1 294541 295596 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 294541..295596 Escherichia coli SMS-3-5 6146033 YP_001742393.1 CDS EcSMS35_0286 NC_010498.1 295648 295941 D identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; putative antitoxin of the YafO-YafN toxin-antitoxin system 295648..295941 Escherichia coli SMS-3-5 6143851 YP_001742394.1 CDS EcSMS35_0288 NC_010498.1 296353 296805 D yafP; identified by match to protein family HMM PF00583; hypothetical protein 296353..296805 Escherichia coli SMS-3-5 6143085 YP_001742395.1 CDS EcSMS35_0289 NC_010498.1 296996 298135 D mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 296996..298135 Escherichia coli SMS-3-5 6146989 YP_001742396.1 CDS prfH NC_010498.1 298132 298746 D similar to release factor 1 and 2; peptide chain release factor-like protein 298132..298746 Escherichia coli SMS-3-5 6146573 YP_001742397.1 CDS pepD NC_010498.1 298803 300260 R identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01893; aminoacyl-histidine dipeptidase complement(298803..300260) Escherichia coli SMS-3-5 6143396 YP_001742398.1 CDS gpt NC_010498.1 300521 300979 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 300521..300979 Escherichia coli SMS-3-5 6147445 YP_001742399.1 CDS frsA NC_010498.1 301071 302315 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 301071..302315 Escherichia coli SMS-3-5 6144512 YP_001742400.1 CDS crl NC_010498.1 302373 302774 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 302373..302774 Escherichia coli SMS-3-5 6145519 YP_001742401.1 CDS phoE NC_010498.1 302813 303868 R identified by match to protein family HMM PF00267; outer membrane phosphoporin protein E complement(302813..303868) Escherichia coli SMS-3-5 6144995 YP_001742402.1 CDS proB NC_010498.1 304156 305259 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 304156..305259 Escherichia coli SMS-3-5 6145427 YP_001742403.1 CDS proA NC_010498.1 305271 306524 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 305271..306524 Escherichia coli SMS-3-5 6146166 YP_001742404.1 CDS EcSMS35_0299 NC_010498.1 306879 308063 D identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 306879..308063 Escherichia coli SMS-3-5 6143653 YP_001742405.1 CDS EcSMS35_0300 NC_010498.1 308165 309130 D identified by similarity to GB:BAA16614.1; hypothetical protein 308165..309130 Escherichia coli SMS-3-5 6146191 YP_001742406.1 CDS EcSMS35_0301 NC_010498.1 309610 310773 R identified by similarity to GB:CAD73582.1; hypothetical protein complement(309610..310773) Escherichia coli SMS-3-5 6143262 YP_001742407.1 CDS EcSMS35_0302 NC_010498.1 310770 311219 R identified by match to protein family HMM PF00072; response regulator complement(310770..311219) Escherichia coli SMS-3-5 6145600 YP_001742408.1 CDS EcSMS35_0303 NC_010498.1 311216 314491 R identified by Glimmer3; putative; hypothetical protein complement(311216..314491) Escherichia coli SMS-3-5 6145078 YP_001742409.1 CDS EcSMS35_0304 NC_010498.1 314956 315267 D identified by match to protein family HMM PF01527; IS911 transposase orfA 314956..315267 Escherichia coli SMS-3-5 6146802 YP_001742410.1 CDS EcSMS35_0305 NC_010498.1 315387 316133 D identified by match to protein family HMM PF00665; IS911 transposase orfB 315387..316133 Escherichia coli SMS-3-5 6146180 YP_001742411.1 CDS EcSMS35_0307 NC_010498.1 316666 317124 D identified by match to protein family HMM PF03230; antirestriction protein 316666..317124 Escherichia coli SMS-3-5 6142595 YP_001742412.1 CDS EcSMS35_0308 NC_010498.1 317136 317615 D identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 317136..317615 Escherichia coli SMS-3-5 6144221 YP_001742413.1 CDS EcSMS35_0309 NC_010498.1 317624 317845 D identified by similarity to GB:ABB61177.1; match to protein family HMM PF06174; hypothetical protein 317624..317845 Escherichia coli SMS-3-5 6143434 YP_001742414.1 CDS EcSMS35_0310 NC_010498.1 317865 318182 D identified by similarity to SP:P52141; match to protein family HMM PF06154; putative antitoxin module of toxin-antitoxin system 317865..318182 Escherichia coli SMS-3-5 6144924 YP_001742415.1 CDS EcSMS35_0311 NC_010498.1 318634 318771 D identified by Glimmer3; putative; hypothetical protein 318634..318771 Escherichia coli SMS-3-5 6144909 YP_001742416.1 CDS EcSMS35_0312 NC_010498.1 318976 319149 D identified by Glimmer3; putative; hypothetical protein 318976..319149 Escherichia coli SMS-3-5 6145208 YP_001742417.1 CDS EcSMS35_0313 NC_010498.1 319364 319978 D identified by match to protein family HMM PF07274; hypothetical protein 319364..319978 Escherichia coli SMS-3-5 6145660 YP_001742418.1 CDS EcSMS35_0314 NC_010498.1 320437 320577 D identified by Glimmer3; putative; hypothetical protein 320437..320577 Escherichia coli SMS-3-5 6143796 YP_001742419.1 CDS EcSMS35_0315 NC_010498.1 320869 321579 R hypothetical protein complement(320869..321579) Escherichia coli SMS-3-5 6142970 YP_001742420.1 CDS EcSMS35_0316 NC_010498.1 321548 323191 R hypothetical protein complement(321548..323191) Escherichia coli SMS-3-5 6143481 YP_001742421.1 CDS EcSMS35_0317 NC_010498.1 323181 325706 R hypothetical protein complement(323181..325706) Escherichia coli SMS-3-5 6146558 YP_001742422.1 CDS EcSMS35_0318 NC_010498.1 325732 326400 R hypothetical protein complement(325732..326400) Escherichia coli SMS-3-5 6147073 YP_001742423.1 CDS matB NC_010498.1 326458 327045 R fimbrillin MatB complement(326458..327045) Escherichia coli SMS-3-5 6145168 YP_001742424.1 CDS matA NC_010498.1 327120 327662 R identified by match to protein family HMM PF00196; fimbrillin MatA complement(327120..327662) Escherichia coli SMS-3-5 6144370 YP_001742425.1 CDS EcSMS35_0321 NC_010498.1 328115 328339 R identified by Glimmer3; putative; hypothetical protein complement(328115..328339) Escherichia coli SMS-3-5 6142662 YP_001742426.1 CDS EcSMS35_0322 NC_010498.1 328398 328517 D identified by Glimmer3; putative; hypothetical protein 328398..328517 Escherichia coli SMS-3-5 6143394 YP_001742427.1 CDS rpmJ NC_010498.1 328746 328886 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 complement(328746..328886) Escherichia coli SMS-3-5 6142757 YP_001742428.1 CDS rpmE2 NC_010498.1 328886 329149 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B complement(328886..329149) Escherichia coli SMS-3-5 6145961 YP_001742429.1 CDS EcSMS35_0325 NC_010498.1 330089 331231 R identified by match to protein family HMM PF00724; oxidoreductase, FAD/FMN-binding complement(330089..331231) Escherichia coli SMS-3-5 6145276 YP_001742430.1 CDS EcSMS35_0326 NC_010498.1 331476 332396 R identified by similarity to GB:AAZ61189.1; hypothetical protein complement(331476..332396) Escherichia coli SMS-3-5 6144914 YP_001742431.1 CDS EcSMS35_0327 NC_010498.1 332553 333479 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 332553..333479 Escherichia coli SMS-3-5 6144224 YP_001742432.1 CDS EcSMS35_0328 NC_010498.1 333679 334572 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 333679..334572 Escherichia coli SMS-3-5 6143070 YP_001742433.1 CDS EcSMS35_0329 NC_010498.1 334603 335592 R identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase complement(334603..335592) Escherichia coli SMS-3-5 6147354 YP_001742434.1 CDS EcSMS35_0330 NC_010498.1 335619 336470 R identified by similarity to GB:ABB80491.1; match to protein family HMM PF00248; organophosphate reductase complement(335619..336470) Escherichia coli SMS-3-5 6146983 YP_001742435.1 CDS EcSMS35_0331 NC_010498.1 337036 341289 D identified by match to protein family HMM PF02369; putative invasin 337036..341289 Escherichia coli SMS-3-5 6146291 YP_001742436.1 CDS EcSMS35_0332 NC_010498.1 341410 342267 R identified by match to protein family HMM PF00165; match to protein family HMM PF06445; AraC family transcriptional regulator complement(341410..342267) Escherichia coli SMS-3-5 6144282 YP_001742437.1 CDS EcSMS35_0333 NC_010498.1 342515 343384 D identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 342515..343384 Escherichia coli SMS-3-5 6144831 YP_001742438.1 CDS EcSMS35_0334 NC_010498.1 343546 344139 R identified by match to protein family HMM PF04224; hypothetical protein complement(343546..344139) Escherichia coli SMS-3-5 6143185 YP_001742439.1 CDS EcSMS35_0335 NC_010498.1 344151 344387 R identified by match to protein family HMM PF07338; hypothetical protein complement(344151..344387) Escherichia coli SMS-3-5 6146127 YP_001742440.1 CDS EcSMS35_0336 NC_010498.1 344496 345821 R Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase complement(344496..345821) Escherichia coli SMS-3-5 6147070 YP_001742441.1 CDS EcSMS35_0337 NC_010498.1 346048 346902 D identified by match to protein family HMM PF00165; AraC family transcriptional regulator 346048..346902 Escherichia coli SMS-3-5 6145113 YP_001742442.1 CDS EcSMS35_0338 NC_010498.1 347428 348147 D identified by match to protein family HMM PF02754; hypothetical protein 347428..348147 Escherichia coli SMS-3-5 6145989 YP_001742443.1 CDS EcSMS35_0339 NC_010498.1 348158 349585 D identified by match to protein family HMM PF02589; match to protein family HMM TIGR00273; iron-sulfur cluster binding protein 348158..349585 Escherichia coli SMS-3-5 6144079 YP_001742444.1 CDS EcSMS35_0340 NC_010498.1 349578 350273 D identified by match to protein family HMM PF02589; hypothetical protein 349578..350273 Escherichia coli SMS-3-5 6146031 YP_001742445.1 CDS EcSMS35_0341 NC_010498.1 350347 350544 R identified by Glimmer3; putative; hypothetical protein complement(350347..350544) Escherichia coli SMS-3-5 6144152 YP_001742446.1 CDS betA NC_010498.1 350805 352493 R catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase complement(350805..352493) Escherichia coli SMS-3-5 6146020 YP_001742447.1 CDS betB NC_010498.1 352507 353979 R catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase complement(352507..353979) Escherichia coli SMS-3-5 6145411 YP_001742448.1 CDS betI NC_010498.1 353993 354580 R HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI complement(353993..354580) Escherichia coli SMS-3-5 6145757 YP_001742449.1 CDS betT NC_010498.1 354709 356742 D proton-motive-force-driven choline transporter; choline transport protein BetT 354709..356742 Escherichia coli SMS-3-5 6144703 YP_001742450.1 CDS EcSMS35_0346 NC_010498.1 357618 358706 D identified by match to protein family HMM PF00196; match to protein family HMM PF00563; LuxR-family transcriptional regulator 357618..358706 Escherichia coli SMS-3-5 6144396 YP_001742451.1 CDS EcSMS35_0347 NC_010498.1 358748 359680 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(358748..359680) Escherichia coli SMS-3-5 6143816 YP_001742452.1 CDS EcSMS35_0348 NC_010498.1 359772 360269 R identified by match to protein family HMM PF06496; hypothetical protein complement(359772..360269) Escherichia coli SMS-3-5 6142857 YP_001742453.1 CDS EcSMS35_0349 NC_010498.1 360527 361132 D identified by match to protein family HMM PF00023; ankyrin repeat-containing protein 360527..361132 Escherichia coli SMS-3-5 6146799 YP_001742454.1 CDS EcSMS35_0350 NC_010498.1 361172 362035 D hypothetical protein 361172..362035 Escherichia coli SMS-3-5 6146546 YP_001742455.1 CDS EcSMS35_0351 NC_010498.1 362025 363572 D identified by match to protein family HMM PF06263; acyl-CoA synthetase 362025..363572 Escherichia coli SMS-3-5 6145842 YP_001742456.1 CDS EcSMS35_0352 NC_010498.1 363572 364990 D identified by match to protein family HMM PF06545; hypothetical protein 363572..364990 Escherichia coli SMS-3-5 6143289 YP_001742457.1 CDS EcSMS35_0353 NC_010498.1 365085 366035 D identified by match to protein family HMM PF00696; putative carbamate kinase 365085..366035 Escherichia coli SMS-3-5 6146364 YP_001742458.1 CDS EcSMS35_0354 NC_010498.1 366045 367427 D metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 366045..367427 Escherichia coli SMS-3-5 6147060 YP_001742459.1 CDS EcSMS35_0355 NC_010498.1 367651 367788 D identified by Glimmer3; putative; hypothetical protein 367651..367788 Escherichia coli SMS-3-5 6145444 YP_001742460.1 CDS EcSMS35_0356 NC_010498.1 367804 368853 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 367804..368853 Escherichia coli SMS-3-5 6144238 YP_001742461.1 CDS EcSMS35_0357 NC_010498.1 369096 369911 D hypothetical protein 369096..369911 Escherichia coli SMS-3-5 6144913 YP_001742462.1 CDS EcSMS35_0359 NC_010498.1 370587 371219 R identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; putative homoserine/threonine efflux protein complement(370587..371219) Escherichia coli SMS-3-5 6143686 YP_001742463.1 CDS EcSMS35_0360 NC_010498.1 371405 371680 D identified by match to protein family HMM PF07338; hypothetical protein 371405..371680 Escherichia coli SMS-3-5 6147351 YP_001742464.1 CDS EcSMS35_0362 NC_010498.1 371707 371829 D identified by Glimmer3; putative; hypothetical protein 371707..371829 Escherichia coli SMS-3-5 6142762 YP_001742465.1 CDS prpR NC_010498.1 371781 373367 R identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF06506; match to protein family HMM TIGR02329; propionate catabolism operon regulatory protein PrpR complement(371781..373367) Escherichia coli SMS-3-5 6143945 YP_001742466.1 CDS prpB NC_010498.1 373606 374496 D catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 373606..374496 Escherichia coli SMS-3-5 6143411 YP_001742467.1 CDS prpC NC_010498.1 374541 375710 D catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 374541..375710 Escherichia coli SMS-3-5 6144059 YP_001742468.1 CDS prpD NC_010498.1 375744 377195 D functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 375744..377195 Escherichia coli SMS-3-5 6145052 YP_001742469.1 CDS prpE NC_010498.1 377235 379121 D catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 377235..379121 Escherichia coli SMS-3-5 6145571 YP_001742470.1 CDS codB NC_010498.1 379358 380617 D identified by match to protein family HMM PF02133; match to protein family HMM TIGR00800; cytosine permease 379358..380617 Escherichia coli SMS-3-5 6144024 YP_001742471.1 CDS codA NC_010498.1 380607 381890 D Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 380607..381890 Escherichia coli SMS-3-5 6144515 YP_001742472.1 CDS cynR NC_010498.1 382023 382922 R controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR complement(382023..382922) Escherichia coli SMS-3-5 6147491 YP_001742473.1 CDS cynT NC_010498.1 383032 383691 D identified by match to protein family HMM PF00484; carbonic anhydrase 383032..383691 Escherichia coli SMS-3-5 6143240 YP_001742474.1 CDS cynS NC_010498.1 383722 384192 D catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 383722..384192 Escherichia coli SMS-3-5 6146225 YP_001742475.1 CDS cynX NC_010498.1 384225 385379 D MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; putative cyanate transporter 384225..385379 Escherichia coli SMS-3-5 6147240 YP_001742476.1 CDS lacA NC_010498.1 385467 386087 R transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase complement(385467..386087) Escherichia coli SMS-3-5 6143596 YP_001742477.1 CDS lacY NC_010498.1 386144 387397 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(386144..387397) Escherichia coli SMS-3-5 6146499 YP_001742478.1 CDS lacZ NC_010498.1 387449 390523 R forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase complement(387449..390523) Escherichia coli SMS-3-5 6144942 YP_001742479.1 CDS lacI NC_010498.1 390646 391728 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(390646..391728) Escherichia coli SMS-3-5 6145584 YP_001742480.1 CDS mhpR NC_010498.1 391805 392650 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR complement(391805..392650) Escherichia coli SMS-3-5 6143939 YP_001742481.1 CDS mhpA NC_010498.1 392829 394493 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 392829..394493 Escherichia coli SMS-3-5 6144565 YP_001742482.1 CDS mhpB NC_010498.1 394495 395439 D catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 394495..395439 Escherichia coli SMS-3-5 6142767 YP_001742483.1 CDS mhpC NC_010498.1 395457 396323 D identified by match to protein family HMM PF00561; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 395457..396323 Escherichia coli SMS-3-5 6143309 YP_001742484.1 CDS mhpD NC_010498.1 396333 397142 D catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 396333..397142 Escherichia coli SMS-3-5 6142755 YP_001742485.1 CDS mhpF NC_010498.1 397139 398089 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 397139..398089 Escherichia coli SMS-3-5 6143312 YP_001742486.1 CDS mhpE NC_010498.1 398086 399099 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 398086..399099 Escherichia coli SMS-3-5 6146682 YP_001742487.1 CDS EcSMS35_0384 NC_010498.1 399275 400486 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00895; putative 3-hydroxyphenylpropionic transporter MhpT 399275..400486 Escherichia coli SMS-3-5 6147081 YP_001742488.1 CDS EcSMS35_0385 NC_010498.1 400588 401127 D hypothetical protein 400588..401127 Escherichia coli SMS-3-5 6144843 YP_001742489.1 CDS fghA2 NC_010498.1 401252 402085 R identified by match to protein family HMM PF00756; match to protein family HMM TIGR02821; S-formylglutathione hydrolase complement(401252..402085) Escherichia coli SMS-3-5 6142701 YP_001742490.1 CDS adhC NC_010498.1 402177 403286 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02818; S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase complement(402177..403286) Escherichia coli SMS-3-5 6143543 YP_001742491.1 CDS EcSMS35_0388 NC_010498.1 403321 403596 R formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR complement(403321..403596) Escherichia coli SMS-3-5 6146576 YP_001742492.1 CDS EcSMS35_0389 NC_010498.1 403781 404554 R identified by Glimmer3; putative; hypothetical protein complement(403781..404554) Escherichia coli SMS-3-5 6144959 YP_001742493.1 CDS EcSMS35_0390 NC_010498.1 404556 404996 R identified by match to protein family HMM PF00132; putative acyltransferase complement(404556..404996) Escherichia coli SMS-3-5 6145596 YP_001742494.1 CDS EcSMS35_0391 NC_010498.1 405115 406311 R identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(405115..406311) Escherichia coli SMS-3-5 6143894 YP_001742495.1 CDS EcSMS35_0392 NC_010498.1 406321 406992 R identified by match to protein family HMM PF02585; putative GlcNAc-PI de-N-acetylase complement(406321..406992) Escherichia coli SMS-3-5 6144387 YP_001742496.1 CDS EcSMS35_0393 NC_010498.1 407430 407609 R hypothetical protein complement(407430..407609) Escherichia coli SMS-3-5 6144455 YP_001742497.1 CDS tauA NC_010498.1 407608 408570 D with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 407608..408570 Escherichia coli SMS-3-5 6145011 YP_001742498.1 CDS tauB NC_010498.1 408584 409351 D Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 408584..409351 Escherichia coli SMS-3-5 6143357 YP_001742499.1 CDS tauC NC_010498.1 409348 410175 D identified by match to protein family HMM PF00528; taurine transporter subunit 409348..410175 Escherichia coli SMS-3-5 6144014 YP_001742500.1 CDS tauD NC_010498.1 410172 411023 D catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 410172..411023 Escherichia coli SMS-3-5 6147272 YP_001742501.1 CDS hemB NC_010498.1 411063 412037 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(411063..412037) Escherichia coli SMS-3-5 6142825 YP_001742502.1 CDS EcSMS35_0400 NC_010498.1 412563 413420 D yaiT; hypothetical protein 412563..413420 Escherichia coli SMS-3-5 6144974 YP_001742503.1 CDS EcSMS35_0399 NC_010498.1 413260 414165 R identified by match to protein family HMM PF00665; IS2 transposase orfB complement(413260..414165) Escherichia coli SMS-3-5 6146712 YP_001742504.1 CDS EcSMS35_0401 NC_010498.1 414123 414533 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(414123..414533) Escherichia coli SMS-3-5 6146719 YP_001742505.1 CDS EcSMS35_0402 NC_010498.1 414664 416808 D identified by match to protein family HMM PF03797; match to protein family HMM TIGR01414; outer membrane autotransporter 414664..416808 Escherichia coli SMS-3-5 6146526 YP_001742506.1 CDS EcSMS35_0403 NC_010498.1 416894 417517 D identified by Glimmer3; putative; putative DNA-binding transcriptional regulator 416894..417517 Escherichia coli SMS-3-5 6147271 YP_001742507.1 CDS ampH NC_010498.1 417518 418675 R this protein has no known enzymatic function; beta-lactam binding protein AmpH complement(417518..418675) Escherichia coli SMS-3-5 6143787 YP_001742508.1 CDS EcSMS35_0405 NC_010498.1 418813 419007 D identified by Glimmer3; putative; hypothetical protein 418813..419007 Escherichia coli SMS-3-5 6144780 YP_001742509.1 CDS smbA NC_010498.1 419027 420247 D in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 419027..420247 Escherichia coli SMS-3-5 6145306 YP_001742510.1 CDS EcSMS35_0407 NC_010498.1 420260 421354 D identified by match to protein family HMM PF07759; putative lipoprotein 420260..421354 Escherichia coli SMS-3-5 6145805 YP_001742511.1 CDS EcSMS35_0408 NC_010498.1 421412 421720 R hypothetical protein complement(421412..421720) Escherichia coli SMS-3-5 6146451 YP_001742512.1 CDS EcSMS35_0409 NC_010498.1 421980 422192 D hypothetical protein 421980..422192 Escherichia coli SMS-3-5 6147177 YP_001742513.1 CDS ddl NC_010498.1 422216 423310 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(422216..423310) Escherichia coli SMS-3-5 6142905 YP_001742514.1 CDS EcSMS35_0411 NC_010498.1 423388 423591 D identified by Glimmer3; putative; hypothetical protein 423388..423591 Escherichia coli SMS-3-5 6143617 YP_001742515.1 CDS EcSMS35_0412 NC_010498.1 423773 424033 D hypothetical protein 423773..424033 Escherichia coli SMS-3-5 6143817 YP_001742516.1 CDS phoA NC_010498.1 424133 425548 D identified by match to protein family HMM PF00245; alkaline phosphatase 424133..425548 Escherichia coli SMS-3-5 6144438 YP_001742517.1 CDS psiF NC_010498.1 425667 425987 D identified by match to protein family HMM PF07769; hypothetical protein 425667..425987 Escherichia coli SMS-3-5 6144693 YP_001742518.1 CDS adrA NC_010498.1 426089 427204 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 426089..427204 Escherichia coli SMS-3-5 6144162 YP_001742519.1 CDS proC NC_010498.1 427221 428030 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(427221..428030) Escherichia coli SMS-3-5 6143200 YP_001742520.1 CDS EcSMS35_0417 NC_010498.1 428150 428608 D identified by match to protein family HMM PF02639; hypothetical protein 428150..428608 Escherichia coli SMS-3-5 6147511 YP_001742521.1 CDS aroL NC_010498.1 428791 429315 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 428791..429315 Escherichia coli SMS-3-5 6146269 YP_001742522.1 CDS EcSMS35_0419 NC_010498.1 429365 429556 D hypothetical protein 429365..429556 Escherichia coli SMS-3-5 6143092 YP_001742523.1 CDS aroM NC_010498.1 429814 430491 D identified by match to protein family HMM PF07302; hypothetical protein 429814..430491 Escherichia coli SMS-3-5 6146102 YP_001742524.1 CDS EcSMS35_0421 NC_010498.1 430563 430847 D identified by match to protein family HMM PF06865; hypothetical protein 430563..430847 Escherichia coli SMS-3-5 6145424 YP_001742525.1 CDS EcSMS35_0422 NC_010498.1 431055 431333 D identified by Glimmer3; putative; hypothetical protein 431055..431333 Escherichia coli SMS-3-5 6143253 YP_001742526.1 CDS rdgC NC_010498.1 431491 432402 R Required for efficient pilin antigenic variation; recombination associated protein complement(431491..432402) Escherichia coli SMS-3-5 6144927 YP_001742527.1 CDS mak NC_010498.1 432527 433435 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 432527..433435 Escherichia coli SMS-3-5 6145580 YP_001742528.1 CDS araJ NC_010498.1 433575 434843 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(433575..434843) Escherichia coli SMS-3-5 6146639 YP_001742529.1 CDS sbcC NC_010498.1 434885 438028 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC complement(434885..438028) Escherichia coli SMS-3-5 6147325 YP_001742530.1 CDS sbcD NC_010498.1 438025 439227 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD complement(438025..439227) Escherichia coli SMS-3-5 6146676 YP_001742531.1 CDS EcSMS35_0428 NC_010498.1 439213 439344 D identified by Glimmer3; putative; hypothetical protein 439213..439344 Escherichia coli SMS-3-5 6147222 YP_001742532.1 CDS phoB NC_010498.1 439417 440106 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 439417..440106 Escherichia coli SMS-3-5 6142940 YP_001742533.1 CDS phoR NC_010498.1 440164 441459 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 440164..441459 Escherichia coli SMS-3-5 6143504 YP_001742534.1 CDS EcSMS35_0431 NC_010498.1 441672 441821 R hypothetical protein complement(441672..441821) Escherichia coli SMS-3-5 6145525 YP_001742535.1 CDS brnQ NC_010498.1 441866 443185 D identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 441866..443185 Escherichia coli SMS-3-5 6144246 YP_001742536.1 CDS proY NC_010498.1 443258 444634 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 443258..444634 Escherichia coli SMS-3-5 6144255 YP_001742537.1 CDS malZ NC_010498.1 444790 446607 D identified by match to protein family HMM PF00128; maltodextrin glucosidase 444790..446607 Escherichia coli SMS-3-5 6144822 YP_001742538.1 CDS EcSMS35_0435 NC_010498.1 446794 448239 D identified by Glimmer3; putative; hypothetical protein 446794..448239 Escherichia coli SMS-3-5 6145378 YP_001742539.1 CDS acpH NC_010498.1 448260 448841 R Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase complement(448260..448841) Escherichia coli SMS-3-5 6145840 YP_001742540.1 CDS queA NC_010498.1 448934 450004 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 448934..450004 Escherichia coli SMS-3-5 6143380 YP_001742541.1 CDS tgt NC_010498.1 450059 451186 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 450059..451186 Escherichia coli SMS-3-5 6146420 YP_001742542.1 CDS yajC NC_010498.1 451209 451541 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 451209..451541 Escherichia coli SMS-3-5 6144445 YP_001742543.1 CDS secD NC_010498.1 451569 453416 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 451569..453416 Escherichia coli SMS-3-5 6147515 YP_001742544.1 CDS secF NC_010498.1 453427 454398 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 453427..454398 Escherichia coli SMS-3-5 6144917 YP_001742545.1 CDS EcSMS35_0442 NC_010498.1 454549 454791 D identified by match to protein family HMM PF03693; match to protein family HMM TIGR02606; CC2985 family addiction module antidote protein 454549..454791 Escherichia coli SMS-3-5 6143551 YP_001742546.1 CDS EcSMS35_0443 NC_010498.1 454784 455065 D identified by match to protein family HMM PF05016; RelE/ParE family plasmid stabilization system protein 454784..455065 Escherichia coli SMS-3-5 6144034 YP_001742547.1 CDS EcSMS35_0444 NC_010498.1 455153 455500 D identified by match to protein family HMM PF01844; hypothetical protein 455153..455500 Escherichia coli SMS-3-5 6147168 YP_001742548.1 CDS tsx1 NC_010498.1 455538 456422 R identified by match to protein family HMM PF03502; nucleoside-specific channel-forming protein Tsx complement(455538..456422) Escherichia coli SMS-3-5 6147520 YP_001742549.1 CDS EcSMS35_0448 NC_010498.1 457626 458834 D identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766; IS605 family transposase orfB 457626..458834 Escherichia coli SMS-3-5 6142930 YP_001742550.1 CDS nrdR NC_010498.1 459158 459607 D identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR 459158..459607 Escherichia coli SMS-3-5 6143940 YP_001742551.1 CDS ribD NC_010498.1 459611 460714 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 459611..460714 Escherichia coli SMS-3-5 6145022 YP_001742552.1 CDS ribH NC_010498.1 460803 461273 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 460803..461273 Escherichia coli SMS-3-5 6144310 YP_001742553.1 CDS nusB NC_010498.1 461293 461712 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 461293..461712 Escherichia coli SMS-3-5 6144760 YP_001742554.1 CDS thiL NC_010498.1 461790 462767 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 461790..462767 Escherichia coli SMS-3-5 6145338 YP_001742555.1 CDS pgpA NC_010498.1 462754 463263 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 462754..463263 Escherichia coli SMS-3-5 6145813 YP_001742556.1 CDS EcSMS35_0455 NC_010498.1 463317 464291 R identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase complement(463317..464291) Escherichia coli SMS-3-5 6146363 YP_001742557.1 CDS dxs NC_010498.1 464346 466208 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(464346..466208) Escherichia coli SMS-3-5 6146939 YP_001742558.1 CDS ispA NC_010498.1 466233 467132 R identified by match to protein family HMM PF00348; geranyltranstransferase complement(466233..467132) Escherichia coli SMS-3-5 6144819 YP_001742559.1 CDS xseB NC_010498.1 467132 467374 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(467132..467374) Escherichia coli SMS-3-5 6142873 YP_001742560.1 CDS thiI NC_010498.1 467580 469028 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 467580..469028 Escherichia coli SMS-3-5 6146108 YP_001742561.1 CDS thiJ NC_010498.1 469082 469672 R identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; DJ-1 family protein complement(469082..469672) Escherichia coli SMS-3-5 6144122 YP_001742562.1 CDS panE NC_010498.1 469635 470546 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(469635..470546) Escherichia coli SMS-3-5 6145856 YP_001742563.1 CDS EcSMS35_0462 NC_010498.1 470714 471205 D putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 470714..471205 Escherichia coli SMS-3-5 6145356 YP_001742564.1 CDS EcSMS35_0463 NC_010498.1 471333 472697 R identified by match to protein family HMM PF07690; major facilitator transporter complement(471333..472697) Escherichia coli SMS-3-5 6144885 YP_001742565.1 CDS EcSMS35_0464 NC_010498.1 472840 472995 D identified by Glimmer3; putative; hypothetical protein 472840..472995 Escherichia coli SMS-3-5 6143775 YP_001742566.1 CDS EcSMS35_0465 NC_010498.1 473104 474039 D identified by match to protein family HMM PF08238; hypothetical protein 473104..474039 Escherichia coli SMS-3-5 6145889 YP_001742567.1 CDS EcSMS35_0466 NC_010498.1 474095 474637 R identified by match to protein family HMM PF00583; acetyltransferase complement(474095..474637) Escherichia coli SMS-3-5 6145221 YP_001742568.1 CDS EcSMS35_0467 NC_010498.1 474621 474932 R identified by match to protein family HMM PF08681; hypothetical protein complement(474621..474932) Escherichia coli SMS-3-5 6144768 YP_001742569.1 CDS cyoE NC_010498.1 475117 476007 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(475117..476007) Escherichia coli SMS-3-5 6144229 YP_001742570.1 CDS cyoD NC_010498.1 476019 476348 R identified by match to protein family HMM PF03626; match to protein family HMM TIGR02847; cytochrome o ubiquinol oxidase subunit IV complement(476019..476348) Escherichia coli SMS-3-5 6146653 YP_001742571.1 CDS cyoC NC_010498.1 476348 476962 R identified by match to protein family HMM PF00510; match to protein family HMM TIGR02842; cytochrome o ubiquinol oxidase subunit III complement(476348..476962) Escherichia coli SMS-3-5 6142989 YP_001742572.1 CDS cyoB NC_010498.1 476952 478943 R identified by match to protein family HMM PF00115; match to protein family HMM TIGR02843; cytochrome o ubiquinol oxidase, subunit I complement(476952..478943) Escherichia coli SMS-3-5 6144798 YP_001742573.1 CDS cyoA NC_010498.1 478965 479912 R identified by match to protein family HMM PF00116; match to protein family HMM PF06481; match to protein family HMM TIGR01433; cytochrome o ubiquinol oxidase subunit II complement(478965..479912) Escherichia coli SMS-3-5 6142834 YP_001742574.1 CDS EcSMS35_0473 NC_010498.1 480214 480357 D identified by Glimmer3; putative; hypothetical protein 480214..480357 Escherichia coli SMS-3-5 6143093 YP_001742575.1 CDS ampG NC_010498.1 480372 481847 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(480372..481847) Escherichia coli SMS-3-5 6146134 YP_001742576.1 CDS EcSMS35_0475 NC_010498.1 481891 482469 R identified by match to protein family HMM PF03923; hypothetical protein complement(481891..482469) Escherichia coli SMS-3-5 6147019 YP_001742577.1 CDS EcSMS35_0476 NC_010498.1 482519 482650 R identified by Glimmer3; putative; hypothetical protein complement(482519..482650) Escherichia coli SMS-3-5 6145371 YP_001742578.1 CDS EcSMS35_0477 NC_010498.1 482774 483091 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 482774..483091 Escherichia coli SMS-3-5 6145105 YP_001742579.1 CDS EcSMS35_0478 NC_010498.1 483142 483288 D identified by Glimmer3; putative; hypothetical protein 483142..483288 Escherichia coli SMS-3-5 6145765 YP_001742580.1 CDS tig NC_010498.1 483435 484733 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 483435..484733 Escherichia coli SMS-3-5 6146485 YP_001742581.1 CDS clpP NC_010498.1 484979 485602 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 484979..485602 Escherichia coli SMS-3-5 6146328 YP_001742582.1 CDS clpX NC_010498.1 485728 487002 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 485728..487002 Escherichia coli SMS-3-5 6147502 YP_001742583.1 CDS lon NC_010498.1 487190 489544 D identified by match to protein family HMM PF00004; match to protein family HMM PF02190; match to protein family HMM PF05362; match to protein family HMM PF07728; match to protein family HMM TIGR00763; DNA-binding ATP-dependent protease La 487190..489544 Escherichia coli SMS-3-5 6146991 YP_001742584.1 CDS hupB NC_010498.1 489753 490025 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 489753..490025 Escherichia coli SMS-3-5 6146438 YP_001742585.1 CDS ppiD NC_010498.1 490217 492088 D identified by match to protein family HMM PF00639; match to protein family HMM PF09312; peptidyl-prolyl cis-trans isomerase (rotamase D) 490217..492088 Escherichia coli SMS-3-5 6145900 YP_001742586.1 CDS EcSMS35_0485 NC_010498.1 492239 492610 D identified by match to protein family HMM TIGR00426; competence protein ComEA 492239..492610 Escherichia coli SMS-3-5 6145885 YP_001742587.1 CDS EcSMS35_0486 NC_010498.1 492716 493114 D identified by match to protein family HMM PF03061; match to protein family HMM TIGR00051; thioesterase family protein 492716..493114 Escherichia coli SMS-3-5 6145234 YP_001742588.1 CDS queC NC_010498.1 493166 493861 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(493166..493861) Escherichia coli SMS-3-5 6143822 YP_001742589.1 CDS EcSMS35_0488 NC_010498.1 493926 495626 R identified by match to protein family HMM PF00496; solute-binding family 5 protein complement(493926..495626) Escherichia coli SMS-3-5 6144306 YP_001742590.1 CDS cof NC_010498.1 495726 496544 D identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hydrolase Cof 495726..496544 Escherichia coli SMS-3-5 6143041 YP_001742591.1 CDS EcSMS35_0490 NC_010498.1 496697 497155 D identified by match to protein family HMM PF01037; AsnC family transcriptional regulator 496697..497155 Escherichia coli SMS-3-5 6147431 YP_001742592.1 CDS mdlA NC_010498.1 497185 498957 D identified by match to protein family HMM PF00005; match to protein family HMM PF00664; putative multidrug transporter membrane\ATP-binding components 497185..498957 Escherichia coli SMS-3-5 6147470 YP_001742593.1 CDS mdlB NC_010498.1 498950 500731 D identified by match to protein family HMM PF00005; match to protein family HMM PF00664; putative multidrug transporter membrane\ATP-binding components 498950..500731 Escherichia coli SMS-3-5 6146932 YP_001742594.1 CDS EcSMS35_0493 NC_010498.1 500745 500885 R identified by Glimmer3; putative; hypothetical protein complement(500745..500885) Escherichia coli SMS-3-5 6144069 YP_001742595.1 CDS glnK NC_010498.1 500912 501250 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 500912..501250 Escherichia coli SMS-3-5 6143375 YP_001742596.1 CDS amt NC_010498.1 501280 502566 D identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836; ammonium transporter 501280..502566 Escherichia coli SMS-3-5 6145333 YP_001742597.1 CDS tesB NC_010498.1 502615 503475 R identified by match to protein family HMM PF02551; match to protein family HMM TIGR00189; acyl-CoA thioesterase II complement(502615..503475) Escherichia coli SMS-3-5 6144876 YP_001742598.1 CDS EcSMS35_0497 NC_010498.1 503693 504265 D putative lipoprotein 503693..504265 Escherichia coli SMS-3-5 6146789 YP_001742599.1 CDS EcSMS35_0498 NC_010498.1 504296 504607 R identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; methylated-DNA-[protein]-cysteine S-methyltransferase complement(504296..504607) Escherichia coli SMS-3-5 6146154 YP_001742600.1 CDS EcSMS35_0499 NC_010498.1 504986 505339 D identified by match to protein family HMM PF07237; hypothetical protein 504986..505339 Escherichia coli SMS-3-5 6146783 YP_001742601.1 CDS EcSMS35_0500 NC_010498.1 505380 506930 R identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein complement(505380..506930) Escherichia coli SMS-3-5 6146235 YP_001742602.1 CDS EcSMS35_0501 NC_010498.1 507094 507564 R hypothetical protein complement(507094..507564) Escherichia coli SMS-3-5 6146525 YP_001742603.1 CDS maa NC_010498.1 507680 508231 R identified by match to protein family HMM PF00132; maltose O-acetyltransferase complement(507680..508231) Escherichia coli SMS-3-5 6143422 YP_001742604.1 CDS EcSMS35_0503 NC_010498.1 508403 508621 R with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein complement(508403..508621) Escherichia coli SMS-3-5 6142749 YP_001742605.1 CDS EcSMS35_0504 NC_010498.1 508647 509021 R hypothetical protein complement(508647..509021) Escherichia coli SMS-3-5 6142599 YP_001742606.1 CDS EcSMS35_0505 NC_010498.1 509567 512716 R identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915; acriflavine resistance protein B complement(509567..512716) Escherichia coli SMS-3-5 6144466 YP_001742607.1 CDS acrA NC_010498.1 512739 513968 R identified by similarity to SP:P0AE06; match to protein family HMM PF00529; match to protein family HMM TIGR01730; acriflavine resistance protein A complement(512739..513968) Escherichia coli SMS-3-5 6144292 YP_001742608.1 CDS acrR NC_010498.1 514074 514721 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 514074..514721 Escherichia coli SMS-3-5 6146028 YP_001742609.1 CDS kefA NC_010498.1 514849 518211 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 514849..518211 Escherichia coli SMS-3-5 6145364 YP_001742610.1 CDS EcSMS35_0509 NC_010498.1 518423 518584 R hypothetical protein complement(518423..518584) Escherichia coli SMS-3-5 6147062 YP_001742611.1 CDS priC NC_010498.1 518598 519125 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(518598..519125) Escherichia coli SMS-3-5 6147027 YP_001742612.1 CDS EcSMS35_0511 NC_010498.1 519195 519572 D identified by match to protein family HMM PF04304; hypothetical protein 519195..519572 Escherichia coli SMS-3-5 6144517 YP_001742613.1 CDS apt NC_010498.1 519725 520276 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 519725..520276 Escherichia coli SMS-3-5 6143588 YP_001742614.1 CDS dnaX NC_010498.1 520405 522336 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 520405..522336 Escherichia coli SMS-3-5 6143044 YP_001742615.1 CDS EcSMS35_0514 NC_010498.1 522389 522718 D ybaB; identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein 522389..522718 Escherichia coli SMS-3-5 6145787 YP_001742616.1 CDS recR NC_010498.1 522718 523323 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 522718..523323 Escherichia coli SMS-3-5 6146337 YP_001742617.1 CDS htpG NC_010498.1 523433 525307 D molecular chaperone; heat shock protein 90 523433..525307 Escherichia coli SMS-3-5 6147205 YP_001742618.1 CDS EcSMS35_0517 NC_010498.1 525373 525498 R identified by Glimmer3; putative; hypothetical protein complement(525373..525498) Escherichia coli SMS-3-5 6142777 YP_001742619.1 CDS adk NC_010498.1 525488 526132 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 525488..526132 Escherichia coli SMS-3-5 6144356 YP_001742620.1 CDS hemH NC_010498.1 526264 527226 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 526264..527226 Escherichia coli SMS-3-5 6143840 YP_001742621.1 CDS aes NC_010498.1 527223 528182 R identified by match to protein family HMM PF07859; acetyl esterase complement(527223..528182) Escherichia coli SMS-3-5 6144494 YP_001742622.1 CDS gsk NC_010498.1 528334 529638 D identified by match to protein family HMM PF00294; inosine kinase 528334..529638 Escherichia coli SMS-3-5 6144471 YP_001742623.1 CDS EcSMS35_0522 NC_010498.1 529768 531444 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; putative cation:proton antiport protein complement(529768..531444) Escherichia coli SMS-3-5 6144864 YP_001742624.1 CDS fsr NC_010498.1 531682 532902 R identified by match to protein family HMM PF07690; fosmidomycin resistance protein complement(531682..532902) Escherichia coli SMS-3-5 6145526 YP_001742625.1 CDS ushA NC_010498.1 533120 534772 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 533120..534772 Escherichia coli SMS-3-5 6146962 YP_001742626.1 CDS EcSMS35_0525 NC_010498.1 534809 535288 R identified by match to protein family HMM PF04073; match to protein family HMM TIGR00011; hypothetical protein complement(534809..535288) Escherichia coli SMS-3-5 6147066 YP_001742627.1 CDS EcSMS35_0526 NC_010498.1 535492 536286 R identified by match to protein family HMM PF07446; GumN family protein complement(535492..536286) Escherichia coli SMS-3-5 6143050 YP_001742628.1 CDS copA NC_010498.1 536590 539094 R identified by match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper exporting ATPase complement(536590..539094) Escherichia coli SMS-3-5 6147486 YP_001742629.1 CDS glsA1 NC_010498.1 539357 540289 D catalyzes the formation of glutamate from glutamine; glutaminase 539357..540289 Escherichia coli SMS-3-5 6144400 YP_001742630.1 CDS EcSMS35_0529 NC_010498.1 540292 541584 D identified by match to protein family HMM PF00324; match to protein family HMM PF01490; match to protein family HMM PF03845; amino acid permease family protein 540292..541584 Escherichia coli SMS-3-5 6143733 YP_001742631.1 CDS cueR NC_010498.1 541709 542116 D activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 541709..542116 Escherichia coli SMS-3-5 6145861 YP_001742632.1 CDS EcSMS35_0531 NC_010498.1 542120 542287 R identified by Glimmer3; putative; hypothetical protein complement(542120..542287) Escherichia coli SMS-3-5 6145139 YP_001742633.1 CDS EcSMS35_0532 NC_010498.1 542320 542742 R identified by similarity to GB:CAL11950.1; putative lipoprotein complement(542320..542742) Escherichia coli SMS-3-5 6144462 YP_001742634.1 CDS EcSMS35_0533 NC_010498.1 542796 543812 R identified by match to protein family HMM PF03895; hypothetical protein complement(542796..543812) Escherichia coli SMS-3-5 6144759 YP_001742635.1 CDS EcSMS35_0534 NC_010498.1 543910 544032 R identified by Glimmer3; putative; hypothetical protein complement(543910..544032) Escherichia coli SMS-3-5 6143528 YP_001742636.1 CDS EcSMS35_0535 NC_010498.1 544057 544185 D identified by Glimmer3; putative; hypothetical protein 544057..544185 Escherichia coli SMS-3-5 6146699 YP_001742637.1 CDS EcSMS35_0536 NC_010498.1 544178 544540 D identified by similarity to GB:ABB60623.1; hypothetical protein 544178..544540 Escherichia coli SMS-3-5 6147097 YP_001742638.1 CDS EcSMS35_0537 NC_010498.1 544643 545101 R identified by match to protein family HMM PF01957; nodulation efficiency family protein complement(544643..545101) Escherichia coli SMS-3-5 6145123 YP_001742639.1 CDS EcSMS35_0538 NC_010498.1 545098 546015 R identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein complement(545098..546015) Escherichia coli SMS-3-5 6145068 YP_001742640.1 CDS EcSMS35_0539 NC_010498.1 546161 546838 D identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein YbbL 546161..546838 Escherichia coli SMS-3-5 6145784 YP_001742641.1 CDS EcSMS35_0540 NC_010498.1 546825 547604 D identified by match to protein family HMM PF03649; match to protein family HMM TIGR00245; hypothetical protein 546825..547604 Escherichia coli SMS-3-5 6143818 YP_001742642.1 CDS ybbN NC_010498.1 547784 548638 R identified by match to protein family HMM PF00085; protein YbbN complement(547784..548638) Escherichia coli SMS-3-5 6146987 YP_001742643.1 CDS EcSMS35_0542 NC_010498.1 548699 549469 R identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase complement(548699..549469) Escherichia coli SMS-3-5 6145808 YP_001742644.1 CDS tesA NC_010498.1 549498 550121 R identified by match to protein family HMM PF00657; multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 complement(549498..550121) Escherichia coli SMS-3-5 6145725 YP_001742645.1 CDS EcSMS35_0544 NC_010498.1 550092 550778 D identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein YbbA 550092..550778 Escherichia coli SMS-3-5 6143759 YP_001742646.1 CDS EcSMS35_0545 NC_010498.1 550775 553189 D identified by match to protein family HMM PF02687; efflux ABC transporter permease 550775..553189 Escherichia coli SMS-3-5 6143083 YP_001742647.1 CDS selU NC_010498.1 553320 554414 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(553320..554414) Escherichia coli SMS-3-5 6142826 YP_001742648.1 CDS EcSMS35_0547 NC_010498.1 554483 555409 R activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS complement(554483..555409) Escherichia coli SMS-3-5 6147241 YP_001742649.1 CDS allA NC_010498.1 555639 556121 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 555639..556121 Escherichia coli SMS-3-5 6147124 YP_001742650.1 CDS allR NC_010498.1 556244 557014 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 556244..557014 Escherichia coli SMS-3-5 6146504 YP_001742651.1 CDS gcl NC_010498.1 557104 558885 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 557104..558885 Escherichia coli SMS-3-5 6145023 YP_001742652.1 CDS hyi NC_010498.1 558898 559674 D identified by match to protein family HMM PF01261; match to protein family HMM TIGR03234; hydroxypyruvate isomerase 558898..559674 Escherichia coli SMS-3-5 6147002 YP_001742653.1 CDS EcSMS35_0552 NC_010498.1 559774 560652 D identified by match to protein family HMM PF03446; match to protein family HMM TIGR01505; 2-hydroxy-3-oxopropionate reductase 559774..560652 Escherichia coli SMS-3-5 6147328 YP_001742654.1 CDS EcSMS35_0553 NC_010498.1 560822 562276 D identified by match to protein family HMM PF02133; match to protein family HMM TIGR00800; allantoin permease 560822..562276 Escherichia coli SMS-3-5 6146612 YP_001742655.1 CDS allB NC_010498.1 562337 563698 D Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 562337..563698 Escherichia coli SMS-3-5 6144951 YP_001742656.1 CDS EcSMS35_0556 NC_010498.1 564855 565067 D identified by similarity to GB:ABD51571.1; IS1 transposase orfA 564855..565067 Escherichia coli SMS-3-5 6145984 YP_001742657.1 CDS EcSMS35_0557 NC_010498.1 565078 565581 D identified by match to protein family HMM PF03400; IS1 transposase orfB 565078..565581 Escherichia coli SMS-3-5 6142694 YP_001742658.1 CDS EcSMS35_0559 NC_010498.1 565854 566999 D identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase II 565854..566999 Escherichia coli SMS-3-5 6142744 YP_001742659.1 CDS EcSMS35_0560 NC_010498.1 567129 567914 R identified by match to protein family HMM PF05899; match to protein family HMM PF07883; match to protein family HMM TIGR03214; hypothetical protein complement(567129..567914) Escherichia coli SMS-3-5 6144793 YP_001742660.1 CDS allC NC_010498.1 567925 569160 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(567925..569160) Escherichia coli SMS-3-5 6146302 YP_001742661.1 CDS allD NC_010498.1 569182 570231 R identified by match to protein family HMM PF02615; match to protein family HMM TIGR03175; ureidoglycolate dehydrogenase complement(569182..570231) Escherichia coli SMS-3-5 6145275 YP_001742662.1 CDS EcSMS35_0563 NC_010498.1 570548 572215 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 570548..572215 Escherichia coli SMS-3-5 6147526 YP_001742663.1 CDS EcSMS35_0564 NC_010498.1 572225 573484 D identified by match to protein family HMM PF06545; hypothetical protein 572225..573484 Escherichia coli SMS-3-5 6146994 YP_001742664.1 CDS EcSMS35_0565 NC_010498.1 573495 574310 D hypothetical protein 573495..574310 Escherichia coli SMS-3-5 6144832 YP_001742665.1 CDS arcC NC_010498.1 574307 575200 D identified by match to protein family HMM PF00696; match to protein family HMM TIGR00746; carbamate kinase 574307..575200 Escherichia coli SMS-3-5 6144237 YP_001742666.1 CDS purK NC_010498.1 575433 576500 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(575433..576500) Escherichia coli SMS-3-5 6145833 YP_001742667.1 CDS purE NC_010498.1 576497 577006 R identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase, catalytic subunit complement(576497..577006) Escherichia coli SMS-3-5 6145322 YP_001742668.1 CDS lpxH NC_010498.1 577123 577845 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(577123..577845) Escherichia coli SMS-3-5 6146506 YP_001742669.1 CDS ppiB NC_010498.1 577848 578342 R identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase B (rotamase B) complement(577848..578342) Escherichia coli SMS-3-5 6146288 YP_001742670.1 CDS cysS NC_010498.1 578516 579901 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 578516..579901 Escherichia coli SMS-3-5 6143051 YP_001742671.1 CDS EcSMS35_0572 NC_010498.1 579937 580458 R identified by match to protein family HMM PF04307; hypothetical protein complement(579937..580458) Escherichia coli SMS-3-5 6142604 YP_001742672.1 CDS EcSMS35_0573 NC_010498.1 580566 580778 R hypothetical protein complement(580566..580778) Escherichia coli SMS-3-5 6144021 YP_001742673.1 CDS folD NC_010498.1 580780 581646 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(580780..581646) Escherichia coli SMS-3-5 6144537 YP_001742674.1 CDS EcSMS35_0575 NC_010498.1 582118 582660 D identified by match to protein family HMM PF00419; type-1 fimbrial protein 582118..582660 Escherichia coli SMS-3-5 6146408 YP_001742675.1 CDS EcSMS35_0576 NC_010498.1 582879 583571 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; chaperone protein FimC-like protein 582879..583571 Escherichia coli SMS-3-5 6146930 YP_001742676.1 CDS sfmD NC_010498.1 583602 586211 D identified by similarity to SP:P77468; match to protein family HMM PF00577; outer membrane usher protein SfmD 583602..586211 Escherichia coli SMS-3-5 6147467 YP_001742677.1 CDS EcSMS35_0578 NC_010498.1 586224 587231 D mannose binding protein FimH-like protein 586224..587231 Escherichia coli SMS-3-5 6147199 YP_001742678.1 CDS EcSMS35_0579 NC_010498.1 587560 587757 D fimbrial protein 587560..587757 Escherichia coli SMS-3-5 6142918 YP_001742679.1 CDS fimZ NC_010498.1 587760 588392 R activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ complement(587760..588392) Escherichia coli SMS-3-5 6143584 YP_001742680.1 CDS EcSMS35_0581 NC_010498.1 588446 588601 D identified by Glimmer3; putative; hypothetical protein 588446..588601 Escherichia coli SMS-3-5 6145540 YP_001742681.1 CDS EcSMS35_0583 NC_010498.1 588756 589517 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(588756..589517) Escherichia coli SMS-3-5 6143669 YP_001742682.1 CDS EcSMS35_0584 NC_010498.1 589700 590590 R hypothetical protein complement(589700..590590) Escherichia coli SMS-3-5 6143789 YP_001742683.1 CDS EcSMS35_0585 NC_010498.1 590591 593563 R identified by match to protein family HMM PF00515; match to protein family HMM PF07719; bacteriophage N4 receptor, outer membrane subunit complement(590591..593563) Escherichia coli SMS-3-5 6144465 YP_001742684.1 CDS nfrB NC_010498.1 593550 595787 R identified by similarity to SP:P0AFA5; match to protein family HMM PF05157; bacteriophage N4 adsorption protein B complement(593550..595787) Escherichia coli SMS-3-5 6143790 YP_001742685.1 CDS cusS NC_010498.1 595937 597379 R identified by similarity to SP:Q8FK37; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM TIGR01386; sensor kinase CusS complement(595937..597379) Escherichia coli SMS-3-5 6144506 YP_001742686.1 CDS cusR NC_010498.1 597369 598052 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(597369..598052) Escherichia coli SMS-3-5 6145212 YP_001742687.1 CDS EcSMS35_0589 NC_010498.1 598099 598254 D identified by Glimmer3; putative; hypothetical protein 598099..598254 Escherichia coli SMS-3-5 6145646 YP_001742688.1 CDS cusC NC_010498.1 598209 599591 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 598209..599591 Escherichia coli SMS-3-5 6143447 YP_001742689.1 CDS cusF NC_010498.1 599615 599947 D periplasmic copper-binding protein 599615..599947 Escherichia coli SMS-3-5 6146483 YP_001742690.1 CDS cusB NC_010498.1 599963 601186 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 599963..601186 Escherichia coli SMS-3-5 6144322 YP_001742691.1 CDS cusA NC_010498.1 601198 604341 D identified by match to protein family HMM PF00873; match to protein family HMM TIGR00914; cation efflux system protein cusA 601198..604341 Escherichia coli SMS-3-5 6143351 YP_001742692.1 CDS pheP NC_010498.1 604443 605819 D identified by match to protein family HMM PF00324; phenylalanine transporter 604443..605819 Escherichia coli SMS-3-5 6146649 YP_001742693.1 CDS EcSMS35_0595 NC_010498.1 605887 607134 R identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel (MscS) family protein complement(605887..607134) Escherichia coli SMS-3-5 6147220 YP_001742694.1 CDS nfnB NC_010498.1 607242 607895 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(607242..607895) Escherichia coli SMS-3-5 6145902 YP_001742695.1 CDS EcSMS35_0597 NC_010498.1 607974 608357 R identified by match to protein family HMM PF04237; hypothetical protein complement(607974..608357) Escherichia coli SMS-3-5 6145077 YP_001742696.1 CDS EcSMS35_0598 NC_010498.1 608422 608670 R identified by match to protein family HMM PF06643; putative lipoprotein complement(608422..608670) Escherichia coli SMS-3-5 6144811 YP_001742697.1 CDS EcSMS35_0599 NC_010498.1 608736 609854 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(608736..609854) Escherichia coli SMS-3-5 6144056 YP_001742698.1 CDS EcSMS35_0600 NC_010498.1 610296 610448 D identified by match to protein family HMM PF01848; Hok/Gef family protein 610296..610448 Escherichia coli SMS-3-5 6143144 YP_001742699.1 CDS entD NC_010498.1 610570 611190 R identified by match to protein family HMM PF01648; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(610570..611190) Escherichia coli SMS-3-5 6147524 YP_001742700.1 CDS fepA NC_010498.1 611365 613605 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(611365..613605) Escherichia coli SMS-3-5 6146581 YP_001742701.1 CDS EcSMS35_0603 NC_010498.1 613598 613729 D identified by Glimmer3; putative; hypothetical protein 613598..613729 Escherichia coli SMS-3-5 6144289 YP_001742702.1 CDS fes NC_010498.1 613848 615050 D identified by match to protein family HMM PF00756; enterobactin/ferric enterobactin esterase 613848..615050 Escherichia coli SMS-3-5 6143378 YP_001742703.1 CDS EcSMS35_0605 NC_010498.1 615053 615271 D identified by match to protein family HMM PF03621; mbtH-like protein 615053..615271 Escherichia coli SMS-3-5 6145583 YP_001742704.1 CDS entF NC_010498.1 615268 619149 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 615268..619149 Escherichia coli SMS-3-5 6145499 YP_001742705.1 CDS fepE NC_010498.1 619364 620497 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 619364..620497 Escherichia coli SMS-3-5 6146797 YP_001742706.1 CDS fepC NC_010498.1 620494 621309 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(620494..621309) Escherichia coli SMS-3-5 6147181 YP_001742707.1 CDS fepG NC_010498.1 621306 622298 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(621306..622298) Escherichia coli SMS-3-5 6146115 YP_001742708.1 CDS fepD NC_010498.1 622295 623299 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(622295..623299) Escherichia coli SMS-3-5 6146974 YP_001742709.1 CDS EcSMS35_0611 NC_010498.1 623410 624660 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 623410..624660 Escherichia coli SMS-3-5 6143615 YP_001742710.1 CDS fepB NC_010498.1 624664 625620 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(624664..625620) Escherichia coli SMS-3-5 6142913 YP_001742711.1 CDS entC NC_010498.1 625809 626984 D identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543; isochorismate synthase, entC 625809..626984 Escherichia coli SMS-3-5 6146295 YP_001742712.1 CDS entE NC_010498.1 626994 628604 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 626994..628604 Escherichia coli SMS-3-5 6143426 YP_001742713.1 CDS entB NC_010498.1 628618 629475 D identified by similarity to SP:P0ADI4; match to protein family HMM PF00550; match to protein family HMM PF00857; isochorismatase 628618..629475 Escherichia coli SMS-3-5 6145796 YP_001742714.1 CDS entA NC_010498.1 629475 630221 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 629475..630221 Escherichia coli SMS-3-5 6145453 YP_001742715.1 CDS EcSMS35_0617 NC_010498.1 630224 630637 D identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein 630224..630637 Escherichia coli SMS-3-5 6144755 YP_001742716.1 CDS cstA NC_010498.1 630818 632923 D identified by match to protein family HMM PF02554; carbon starvation protein A 630818..632923 Escherichia coli SMS-3-5 6144235 YP_001742717.1 CDS EcSMS35_0619 NC_010498.1 633036 633233 D identified by match to protein family HMM PF04328; hypothetical protein 633036..633233 Escherichia coli SMS-3-5 6144519 YP_001742718.1 CDS EcSMS35_0620 NC_010498.1 633243 634331 R member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein complement(633243..634331) Escherichia coli SMS-3-5 6144000 YP_001742719.1 CDS EcSMS35_0621 NC_010498.1 634440 635600 D catalyzes the transfer of an amino moiety; putative aminotransferase 634440..635600 Escherichia coli SMS-3-5 6143367 YP_001742720.1 CDS EcSMS35_0622 NC_010498.1 635601 636218 R identified by similarity to GB:AAM53134.1; match to protein family HMM PF02195; immunoglobulin-binding regulator family protein complement(635601..636218) Escherichia coli SMS-3-5 6142835 YP_001742721.1 CDS EcSMS35_0623 NC_010498.1 636203 637423 R identified by match to protein family HMM PF01507; phosphoadenosine phosphosulfate reductase family protein complement(636203..637423) Escherichia coli SMS-3-5 6143010 YP_001742722.1 CDS EcSMS35_0624 NC_010498.1 637570 638472 R identified by match to protein family HMM PF00126; LysR family transcriptional regulator complement(637570..638472) Escherichia coli SMS-3-5 6144180 YP_001742723.1 CDS dsbG NC_010498.1 638677 639483 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(638677..639483) Escherichia coli SMS-3-5 6142980 YP_001742724.1 CDS ahpC NC_010498.1 639795 640358 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 639795..640358 Escherichia coli SMS-3-5 6143388 YP_001742725.1 CDS ahpF NC_010498.1 640457 642052 D identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR03140; alkyl hydroperoxide reductase subunit F 640457..642052 Escherichia coli SMS-3-5 6146440 YP_001742726.1 CDS uspG NC_010498.1 642173 642601 R identified by match to protein family HMM PF00582; universal stress protein G complement(642173..642601) Escherichia coli SMS-3-5 6146391 YP_001742727.1 CDS rnk NC_010498.1 642957 643367 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(642957..643367) Escherichia coli SMS-3-5 6145207 YP_001742728.1 CDS rna NC_010498.1 643597 644403 R identified by match to protein family HMM PF00445; ribonuclease I complement(643597..644403) Escherichia coli SMS-3-5 6145714 YP_001742729.1 CDS EcSMS35_0631 NC_010498.1 644517 645947 R identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; sodium:sulfate symporter family protein complement(644517..645947) Escherichia coli SMS-3-5 6143864 YP_001742730.1 CDS citG NC_010498.1 646030 646908 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(646030..646908) Escherichia coli SMS-3-5 6144853 YP_001742731.1 CDS citX NC_010498.1 646883 647434 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase complement(646883..647434) Escherichia coli SMS-3-5 6147225 YP_001742732.1 CDS citF NC_010498.1 647438 648970 R identified by match to protein family HMM PF04223; match to protein family HMM TIGR01584; citrate lyase, alpha subunit complement(647438..648970) Escherichia coli SMS-3-5 6147479 YP_001742733.1 CDS citE NC_010498.1 648981 649889 R identified by match to protein family HMM PF03328; match to protein family HMM TIGR01588; citrate (pro-3S)-lyase, beta subunit complement(648981..649889) Escherichia coli SMS-3-5 6143274 YP_001742734.1 CDS citD NC_010498.1 649886 650182 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(649886..650182) Escherichia coli SMS-3-5 6146119 YP_001742735.1 CDS citC NC_010498.1 650197 651255 R identified by match to protein family HMM PF00583; match to protein family HMM PF08218; match to protein family HMM TIGR00124; match to protein family HMM TIGR00125; [citrate (pro-3S)-lyase] ligase complement(650197..651255) Escherichia coli SMS-3-5 6146848 YP_001742736.1 CDS dpiB NC_010498.1 651634 653292 D identified by match to protein family HMM PF02518; sensor histidine kinase DpiB 651634..653292 Escherichia coli SMS-3-5 6145500 YP_001742737.1 CDS dpiA NC_010498.1 653261 653941 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 653261..653941 Escherichia coli SMS-3-5 6146190 YP_001742738.1 CDS dcuC NC_010498.1 653982 655367 R responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC complement(653982..655367) Escherichia coli SMS-3-5 6144126 YP_001742739.1 CDS EcSMS35_0642 NC_010498.1 656167 657159 R identified by match to protein family HMM PF01609; IS5 transposase complement(656167..657159) Escherichia coli SMS-3-5 6143361 YP_001742740.1 CDS cspE NC_010498.1 657890 658099 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 657890..658099 Escherichia coli SMS-3-5 6147009 YP_001742741.1 CDS crcB NC_010498.1 658153 658536 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(658153..658536) Escherichia coli SMS-3-5 6146296 YP_001742742.1 CDS EcSMS35_0646 NC_010498.1 658632 659420 D identified by match to protein family HMM PF00795; carbon-nitrogen family hydrolase 658632..659420 Escherichia coli SMS-3-5 6143433 YP_001742743.1 CDS tatE NC_010498.1 659549 659752 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 659549..659752 Escherichia coli SMS-3-5 6147525 YP_001742744.1 CDS lipA NC_010498.1 659853 660818 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(659853..660818) Escherichia coli SMS-3-5 6146008 YP_001742745.1 CDS EcSMS35_0649 NC_010498.1 661027 661980 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator complement(661027..661980) Escherichia coli SMS-3-5 6145484 YP_001742746.1 CDS lipB NC_010498.1 662240 662881 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(662240..662881) Escherichia coli SMS-3-5 6144143 YP_001742747.1 CDS EcSMS35_0651 NC_010498.1 662982 663245 R identified by match to protein family HMM PF04359; hypothetical protein complement(662982..663245) Escherichia coli SMS-3-5 6143169 YP_001742748.1 CDS dacA NC_010498.1 663355 664566 R penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A complement(663355..664566) Escherichia coli SMS-3-5 6146184 YP_001742749.1 CDS rlpA NC_010498.1 664706 665794 R identified by match to protein family HMM PF03330; match to protein family HMM PF05036; match to protein family HMM TIGR00413; rare lipoprotein A complement(664706..665794) Escherichia coli SMS-3-5 6143012 YP_001742750.1 CDS mrdB NC_010498.1 665805 666917 R identified by match to protein family HMM PF01098; match to protein family HMM TIGR02210; cell wall shape-determining protein complement(665805..666917) Escherichia coli SMS-3-5 6147449 YP_001742751.1 CDS mrdA NC_010498.1 666920 668821 R identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM TIGR03423; penicillin-binding protein 2 complement(666920..668821) Escherichia coli SMS-3-5 6144824 YP_001742752.1 CDS EcSMS35_0656 NC_010498.1 668852 669319 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(668852..669319) Escherichia coli SMS-3-5 6143882 YP_001742753.1 CDS EcSMS35_0657 NC_010498.1 669323 669640 R identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; hypothetical protein complement(669323..669640) Escherichia coli SMS-3-5 6145983 YP_001742754.1 CDS cobC NC_010498.1 669900 670511 R identified by similarity to SP:P52086; match to protein family HMM PF00300; match to protein family HMM TIGR03162; alpha-ribazole phosphatase complement(669900..670511) Escherichia coli SMS-3-5 6145466 YP_001742755.1 CDS nadD NC_010498.1 670535 671176 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(670535..671176) Escherichia coli SMS-3-5 6147386 YP_001742756.1 CDS holA NC_010498.1 671178 672209 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(671178..672209) Escherichia coli SMS-3-5 6146832 YP_001742757.1 CDS EcSMS35_0661 NC_010498.1 672209 672790 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(672209..672790) Escherichia coli SMS-3-5 6143952 YP_001742758.1 CDS leuS NC_010498.1 672805 675387 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(672805..675387) Escherichia coli SMS-3-5 6144473 YP_001742759.1 CDS EcSMS35_0663 NC_010498.1 675622 676104 D identified by match to protein family HMM PF07295; hypothetical protein 675622..676104 Escherichia coli SMS-3-5 6143063 YP_001742760.1 CDS EcSMS35_0665 NC_010498.1 676070 676183 D identified by Glimmer3; putative; hypothetical protein 676070..676183 Escherichia coli SMS-3-5 6147461 YP_001742761.1 CDS EcSMS35_0664 NC_010498.1 676175 677152 R identified by Glimmer3; putative; hypothetical protein complement(676175..677152) Escherichia coli SMS-3-5 6146372 YP_001742762.1 CDS EcSMS35_0666 NC_010498.1 677316 678023 D identified by match to protein family HMM PF06889; hypothetical protein 677316..678023 Escherichia coli SMS-3-5 6146921 YP_001742763.1 CDS EcSMS35_0667 NC_010498.1 678020 679447 D identified by match to protein family HMM PF00226; DnaJ domain-containing protein 678020..679447 Escherichia coli SMS-3-5 6144160 YP_001742764.1 CDS EcSMS35_0668 NC_010498.1 679457 680011 R identified by match to protein family HMM PF08238; hypothetical protein complement(679457..680011) Escherichia coli SMS-3-5 6145875 YP_001742765.1 CDS EcSMS35_0669 NC_010498.1 680113 680820 D identified by match to protein family HMM PF06889; hypothetical protein 680113..680820 Escherichia coli SMS-3-5 6142850 YP_001742766.1 CDS EcSMS35_0670 NC_010498.1 680817 682268 D identified by match to protein family HMM PF00226; DnaJ domain-containing protein 680817..682268 Escherichia coli SMS-3-5 6144418 YP_001742767.1 CDS hscC NC_010498.1 682379 684049 R identified by match to protein family HMM PF00012; DnaK family protein HscC complement(682379..684049) Escherichia coli SMS-3-5 6146172 YP_001742768.1 CDS rihA NC_010498.1 684133 685068 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(684133..685068) Escherichia coli SMS-3-5 6143229 YP_001742769.1 CDS gltL NC_010498.1 685186 685911 R identified by match to protein family HMM PF00005; glutamate/aspartate ABC transporter ATP-binding protein complement(685186..685911) Escherichia coli SMS-3-5 6143311 YP_001742770.1 CDS gltK NC_010498.1 685911 686585 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamate/aspartate ABC transporter permease GltK complement(685911..686585) Escherichia coli SMS-3-5 6144523 YP_001742771.1 CDS gltJ NC_010498.1 686585 687325 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamate/aspartate ABC transporter permease GltJ complement(686585..687325) Escherichia coli SMS-3-5 6147451 YP_001742772.1 CDS gltI NC_010498.1 687495 688403 R identified by match to protein family HMM PF00497; glutamate and aspartate transporter subunit complement(687495..688403) Escherichia coli SMS-3-5 6145549 YP_001742773.1 CDS EcSMS35_0677 NC_010498.1 688546 688665 R identified by Glimmer3; putative; hypothetical protein complement(688546..688665) Escherichia coli SMS-3-5 6144266 YP_001742774.1 CDS EcSMS35_0679 NC_010498.1 688693 688815 D identified by Glimmer3; putative; hypothetical protein 688693..688815 Escherichia coli SMS-3-5 6147227 YP_001742775.1 CDS lnt NC_010498.1 688800 690338 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(688800..690338) Escherichia coli SMS-3-5 6146388 YP_001742776.1 CDS corC NC_010498.1 690363 691241 R identified by match to protein family HMM PF00571; match to protein family HMM PF03471; magnesium and cobalt efflux protein CorC complement(690363..691241) Escherichia coli SMS-3-5 6145263 YP_001742777.1 CDS EcSMS35_0681 NC_010498.1 691331 691798 R identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; putative metalloprotease complement(691331..691798) Escherichia coli SMS-3-5 6146937 YP_001742778.1 CDS EcSMS35_0682 NC_010498.1 691795 692835 R identified by match to protein family HMM PF02562; PhoH family protein complement(691795..692835) Escherichia coli SMS-3-5 6145280 YP_001742779.1 CDS EcSMS35_0683 NC_010498.1 692894 693013 R identified by Glimmer3; putative; hypothetical protein complement(692894..693013) Escherichia coli SMS-3-5 6145938 YP_001742780.1 CDS miaB NC_010498.1 692988 694412 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(692988..694412) Escherichia coli SMS-3-5 6146105 YP_001742781.1 CDS ubiF NC_010498.1 694558 695733 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 694558..695733 Escherichia coli SMS-3-5 6144074 YP_001742782.1 CDS asnB NC_010498.1 697033 698697 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(697033..698697) Escherichia coli SMS-3-5 6143656 YP_001742783.1 CDS EcSMS35_0694 NC_010498.1 698666 698830 D putative lipoprotein 698666..698830 Escherichia coli SMS-3-5 6142887 YP_001742784.1 CDS nagD NC_010498.1 698954 699706 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01460; UMP phosphatase complement(698954..699706) Escherichia coli SMS-3-5 6147371 YP_001742785.1 CDS nagC NC_010498.1 699754 700974 R identified by match to protein family HMM PF00480; N-acetylglucosamine repressor complement(699754..700974) Escherichia coli SMS-3-5 6146508 YP_001742786.1 CDS nagA NC_010498.1 700983 702131 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(700983..702131) Escherichia coli SMS-3-5 6146163 YP_001742787.1 CDS nagB NC_010498.1 702191 702991 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(702191..702991) Escherichia coli SMS-3-5 6146998 YP_001742788.1 CDS EcSMS35_0699 NC_010498.1 703040 703174 R identified by Glimmer3; putative; hypothetical protein complement(703040..703174) Escherichia coli SMS-3-5 6146385 YP_001742789.1 CDS nagE NC_010498.1 703324 705270 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 703324..705270 Escherichia coli SMS-3-5 6146947 YP_001742790.1 CDS EcSMS35_0700 NC_010498.1 705240 705395 R identified by Glimmer3; putative; hypothetical protein complement(705240..705395) Escherichia coli SMS-3-5 6145343 YP_001742791.1 CDS glnS NC_010498.1 705473 707137 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 705473..707137 Escherichia coli SMS-3-5 6146950 YP_001742792.1 CDS EcSMS35_0703 NC_010498.1 707579 708985 D identified by match to protein family HMM PF03573; OprD family outer membrane porin 707579..708985 Escherichia coli SMS-3-5 6145855 YP_001742793.1 CDS EcSMS35_0704 NC_010498.1 709035 709361 D putative lipoprotein 709035..709361 Escherichia coli SMS-3-5 6144260 YP_001742794.1 CDS fur NC_010498.1 709445 709891 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(709445..709891) Escherichia coli SMS-3-5 6144253 YP_001742795.1 CDS fldA NC_010498.1 710180 710710 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(710180..710710) Escherichia coli SMS-3-5 6144776 YP_001742796.1 CDS EcSMS35_0707 NC_010498.1 710850 711143 R identified by match to protein family HMM PF01402; LexA regulated protein complement(710850..711143) Escherichia coli SMS-3-5 6143227 YP_001742797.1 CDS ybfF NC_010498.1 711283 712047 R identified by match to protein family HMM PF00561; match to protein family HMM PF07819; hypothetical protein complement(711283..712047) Escherichia coli SMS-3-5 6146140 YP_001742798.1 CDS seqA NC_010498.1 712232 712777 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 712232..712777 Escherichia coli SMS-3-5 6143164 YP_001742799.1 CDS pgm NC_010498.1 712803 714443 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 712803..714443 Escherichia coli SMS-3-5 6143436 YP_001742800.1 CDS EcSMS35_0711 NC_010498.1 714648 715142 D YbfP; putative lipoprotein 714648..715142 Escherichia coli SMS-3-5 6146729 YP_001742801.1 CDS EcSMS35_0712 NC_010498.1 715183 715833 R identified by similarity to GB:ABB11945.1; hypothetical protein complement(715183..715833) Escherichia coli SMS-3-5 6146400 YP_001742802.1 CDS EcSMS35_0713 NC_010498.1 715911 716060 R identified by Glimmer3; putative; hypothetical protein complement(715911..716060) Escherichia coli SMS-3-5 6144219 YP_001742803.1 CDS potE NC_010498.1 716182 717501 R catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter complement(716182..717501) Escherichia coli SMS-3-5 6145530 YP_001742804.1 CDS speF NC_010498.1 717498 719696 R identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; ornithine decarboxylase complement(717498..719696) Escherichia coli SMS-3-5 6142751 YP_001742805.1 CDS kdpE NC_010498.1 720292 720969 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(720292..720969) Escherichia coli SMS-3-5 6144837 YP_001742806.1 CDS kdpD NC_010498.1 720966 723650 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(720966..723650) Escherichia coli SMS-3-5 6147135 YP_001742807.1 CDS kdpC NC_010498.1 723643 724215 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(723643..724215) Escherichia coli SMS-3-5 6146466 YP_001742808.1 CDS kdpB NC_010498.1 724224 726272 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(724224..726272) Escherichia coli SMS-3-5 6147426 YP_001742809.1 CDS kdpA NC_010498.1 726295 727968 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(726295..727968) Escherichia coli SMS-3-5 6142899 YP_001742810.1 CDS EcSMS35_0721 NC_010498.1 728370 728576 D hypothetical protein 728370..728576 Escherichia coli SMS-3-5 6145991 YP_001742811.1 CDS EcSMS35_0722 NC_010498.1 728677 729186 D identified by match to protein family HMM PF08349; hypothetical protein 728677..729186 Escherichia coli SMS-3-5 6144522 YP_001742812.1 CDS phrB NC_010498.1 729183 730601 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 729183..730601 Escherichia coli SMS-3-5 6145206 YP_001742813.1 CDS EcSMS35_0724 NC_010498.1 730643 732124 R identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924; amino acid/peptide transporter complement(730643..732124) Escherichia coli SMS-3-5 6145701 YP_001742814.1 CDS EcSMS35_0725 NC_010498.1 732395 733138 D identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; putative hydrolase-oxidase 732395..733138 Escherichia coli SMS-3-5 6146616 YP_001742815.1 CDS EcSMS35_0726 NC_010498.1 733161 733817 D identified by match to protein family HMM PF02682; match to protein family HMM TIGR00370; allophanate hydrolase, subunit 1 733161..733817 Escherichia coli SMS-3-5 6147176 YP_001742816.1 CDS EcSMS35_0727 NC_010498.1 733811 734743 D identified by match to protein family HMM PF02626; match to protein family HMM TIGR00724; allophanate hydrolase, subunit 2 733811..734743 Escherichia coli SMS-3-5 6142735 YP_001742817.1 CDS EcSMS35_0728 NC_010498.1 734733 735467 D identified by match to protein family HMM PF03746; LamB/YcsF family protein 734733..735467 Escherichia coli SMS-3-5 6146353 YP_001742818.1 CDS nei NC_010498.1 735503 736294 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 735503..736294 Escherichia coli SMS-3-5 6146476 YP_001742819.1 CDS abrB NC_010498.1 736291 737337 R identified by match to protein family HMM PF05145; match to protein family HMM TIGR03082; protein AbrB complement(736291..737337) Escherichia coli SMS-3-5 6147413 YP_001742820.1 CDS EcSMS35_0731 NC_010498.1 737489 737863 R identified by similarity to GB:AAZ87425.1; hypothetical protein complement(737489..737863) Escherichia coli SMS-3-5 6146088 YP_001742821.1 CDS gltA NC_010498.1 738010 739293 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(738010..739293) Escherichia coli SMS-3-5 6146855 YP_001742822.1 CDS sdhC NC_010498.1 739987 740391 D identified by match to protein family HMM PF01127; match to protein family HMM TIGR02970; succinate dehydrogenase cytochrome b556 large membrane subunit 739987..740391 Escherichia coli SMS-3-5 6147465 YP_001742823.1 CDS sdhD NC_010498.1 740385 740732 D identified by match to protein family HMM TIGR02968; succinate dehydrogenase cytochrome b556 small membrane subunit 740385..740732 Escherichia coli SMS-3-5 6144038 YP_001742824.1 CDS sdhA NC_010498.1 740732 742498 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 740732..742498 Escherichia coli SMS-3-5 6143566 YP_001742825.1 CDS sdhB NC_010498.1 742514 743230 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 742514..743230 Escherichia coli SMS-3-5 6145696 YP_001742826.1 CDS sucA NC_010498.1 743431 746232 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 743431..746232 Escherichia coli SMS-3-5 6145269 YP_001742827.1 CDS sucB NC_010498.1 746247 747464 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 746247..747464 Escherichia coli SMS-3-5 6145713 YP_001742828.1 CDS sucC NC_010498.1 747558 748724 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 747558..748724 Escherichia coli SMS-3-5 6145198 YP_001742829.1 CDS sucD NC_010498.1 748724 749593 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 748724..749593 Escherichia coli SMS-3-5 6142804 YP_001742830.1 CDS EcSMS35_0742 NC_010498.1 749842 749988 D identified by similarity to GB:ABM24414.1; hypothetical protein 749842..749988 Escherichia coli SMS-3-5 6146820 YP_001742831.1 CDS EcSMS35_0743 NC_010498.1 750259 751164 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 750259..751164 Escherichia coli SMS-3-5 6143917 YP_001742832.1 CDS cobO NC_010498.1 751198 751800 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(751198..751800) Escherichia coli SMS-3-5 6143402 YP_001742833.1 CDS EcSMS35_0745 NC_010498.1 751810 753462 R identified by match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; tartrate/fumarate family Fe-S type hydro-lyase complement(751810..753462) Escherichia coli SMS-3-5 6143162 YP_001742834.1 CDS EcSMS35_0746 NC_010498.1 753570 754850 R identified by similarity to SP:P24943; match to protein family HMM PF00375; dicarboxylate/amino acid:cation family protein complement(753570..754850) Escherichia coli SMS-3-5 6144114 YP_001742835.1 CDS EcSMS35_0747 NC_010498.1 755011 755328 R identified by similarity to GB:CAL14063.1; hypothetical protein complement(755011..755328) Escherichia coli SMS-3-5 6144386 YP_001742836.1 CDS EcSMS35_0748 NC_010498.1 755325 756695 R hypothetical protein complement(755325..756695) Escherichia coli SMS-3-5 6145143 YP_001742837.1 CDS EcSMS35_0749 NC_010498.1 756699 757940 R identified by match to protein family HMM PF05034; match to protein family HMM PF07476; match to protein family HMM TIGR01502; methylaspartate ammonia-lyase complement(756699..757940) Escherichia coli SMS-3-5 6144174 YP_001742838.1 CDS mutE NC_010498.1 757940 759385 R identified by match to protein family HMM PF06368; match to protein family HMM TIGR01503; methylaspartate mutase, E subunit complement(757940..759385) Escherichia coli SMS-3-5 6143862 YP_001742839.1 CDS EcSMS35_0751 NC_010498.1 759404 760792 R identified by similarity to GB:BAB34186.1; match to protein family HMM TIGR01319; putative glutamate mutase mutL complement(759404..760792) Escherichia coli SMS-3-5 6142704 YP_001742840.1 CDS mamA NC_010498.1 760792 761241 R converts methylaspartate to L-glutamate; methylaspartate mutase subunit S complement(760792..761241) Escherichia coli SMS-3-5 6147111 YP_001742841.1 CDS EcSMS35_0753 NC_010498.1 761788 762210 R identified by Glimmer3; putative; hypothetical protein complement(761788..762210) Escherichia coli SMS-3-5 6142715 YP_001742842.1 CDS EcSMS35_0754 NC_010498.1 762291 763235 R identified by Glimmer3; putative; hypothetical protein complement(762291..763235) Escherichia coli SMS-3-5 6147306 YP_001742843.1 CDS cydA NC_010498.1 764041 765609 D identified by match to protein family HMM PF01654; cytochrome d ubiquinol oxidase, subunit I 764041..765609 Escherichia coli SMS-3-5 6146606 YP_001742844.1 CDS cydB1 NC_010498.1 765625 766764 D identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203; cytochrome d ubiquinol oxidase, subunit II 765625..766764 Escherichia coli SMS-3-5 6145610 YP_001742845.1 CDS EcSMS35_0757 NC_010498.1 766779 766892 D identified by match to protein family HMM PF08173; match to protein family HMM TIGR02106; cyd operon protein YbgT 766779..766892 Escherichia coli SMS-3-5 6144952 YP_001742846.1 CDS EcSMS35_0758 NC_010498.1 766892 767185 D identified by match to protein family HMM TIGR02112; hypothetical protein 766892..767185 Escherichia coli SMS-3-5 6144550 YP_001742847.1 CDS ybgC NC_010498.1 767335 767739 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 767335..767739 Escherichia coli SMS-3-5 6146249 YP_001742848.1 CDS tolQ NC_010498.1 767736 768428 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 767736..768428 Escherichia coli SMS-3-5 6145547 YP_001742849.1 CDS tolR NC_010498.1 768432 768860 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 768432..768860 Escherichia coli SMS-3-5 6145209 YP_001742850.1 CDS tolA NC_010498.1 768925 770205 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 768925..770205 Escherichia coli SMS-3-5 6144526 YP_001742851.1 CDS tolB NC_010498.1 770335 771630 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 770335..771630 Escherichia coli SMS-3-5 6143437 YP_001742852.1 CDS pal NC_010498.1 771665 772186 D identified by match to protein family HMM PF00691; match to protein family HMM TIGR02802; peptidoglycan-associated outer membrane lipoprotein 771665..772186 Escherichia coli SMS-3-5 6142727 YP_001742853.1 CDS ygbF NC_010498.1 772196 772987 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 772196..772987 Escherichia coli SMS-3-5 6147282 YP_001742854.1 CDS nadA NC_010498.1 774104 775147 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 774104..775147 Escherichia coli SMS-3-5 6143637 YP_001742855.1 CDS pnuC NC_010498.1 775185 775904 D identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter PnuC 775185..775904 Escherichia coli SMS-3-5 6146199 YP_001742856.1 CDS EcSMS35_0776 NC_010498.1 776956 777336 R hypothetical protein complement(776956..777336) Escherichia coli SMS-3-5 6147423 YP_001742857.1 CDS aroG NC_010498.1 777652 778704 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 777652..778704 Escherichia coli SMS-3-5 6142849 YP_001742858.1 CDS gpmA NC_010498.1 778852 779604 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(778852..779604) Escherichia coli SMS-3-5 6143536 YP_001742859.1 CDS galM NC_010498.1 779807 780847 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(779807..780847) Escherichia coli SMS-3-5 6145327 YP_001742860.1 CDS galK NC_010498.1 780841 781989 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(780841..781989) Escherichia coli SMS-3-5 6145907 YP_001742861.1 CDS galT NC_010498.1 781993 783039 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(781993..783039) Escherichia coli SMS-3-5 6143889 YP_001742862.1 CDS galE NC_010498.1 783049 784065 R identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF05368; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-galactose-4-epimerase complement(783049..784065) Escherichia coli SMS-3-5 6144838 YP_001742863.1 CDS modF NC_010498.1 784327 785799 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF complement(784327..785799) Escherichia coli SMS-3-5 6142661 YP_001742864.1 CDS modE NC_010498.1 785867 786655 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(785867..786655) Escherichia coli SMS-3-5 6143026 YP_001742865.1 CDS EcSMS35_0785 NC_010498.1 786784 786933 D hypothetical protein 786784..786933 Escherichia coli SMS-3-5 6144655 YP_001742866.1 CDS modA NC_010498.1 787100 787873 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 787100..787873 Escherichia coli SMS-3-5 6142953 YP_001742867.1 CDS modB NC_010498.1 787873 788562 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 787873..788562 Escherichia coli SMS-3-5 6142598 YP_001742868.1 CDS modC NC_010498.1 788565 789623 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 788565..789623 Escherichia coli SMS-3-5 6146559 YP_001742869.1 CDS ybhA NC_010498.1 789624 790442 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(789624..790442) Escherichia coli SMS-3-5 6146220 YP_001742870.1 CDS pgl NC_010498.1 790597 791592 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 790597..791592 Escherichia coli SMS-3-5 6146723 YP_001742871.1 CDS EcSMS35_0791 NC_010498.1 791633 792586 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(791633..792586) Escherichia coli SMS-3-5 6143946 YP_001742872.1 CDS EcSMS35_0792 NC_010498.1 792770 793822 D identified by match to protein family HMM PF04303; hypothetical protein 792770..793822 Escherichia coli SMS-3-5 6144585 YP_001742873.1 CDS EcSMS35_0793 NC_010498.1 793898 795331 D identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; anion transporter 793898..795331 Escherichia coli SMS-3-5 6142643 YP_001742874.1 CDS EcSMS35_0794 NC_010498.1 795514 797775 D identified by match to protein family HMM PF00330; match to protein family HMM PF00694; hypothetical protein 795514..797775 Escherichia coli SMS-3-5 6143163 YP_001742875.1 CDS EcSMS35_0795 NC_010498.1 797846 799129 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase complement(797846..799129) Escherichia coli SMS-3-5 6143264 YP_001742876.1 CDS EcSMS35_0796 NC_010498.1 799281 799757 R YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein complement(799281..799757) Escherichia coli SMS-3-5 6142734 YP_001742877.1 CDS bioA NC_010498.1 799816 801168 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase complement(799816..801168) Escherichia coli SMS-3-5 6144408 YP_001742878.1 CDS bioB NC_010498.1 801192 802232 D identified by match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR00433; biotin synthase 801192..802232 Escherichia coli SMS-3-5 6144002 YP_001742879.1 CDS bioF NC_010498.1 802229 803383 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 802229..803383 Escherichia coli SMS-3-5 6144826 YP_001742880.1 CDS bioC NC_010498.1 803370 804125 D putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 803370..804125 Escherichia coli SMS-3-5 6144303 YP_001742881.1 CDS bioD NC_010498.1 804118 804795 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 804118..804795 Escherichia coli SMS-3-5 6145807 YP_001742882.1 CDS uvrB NC_010498.1 805374 807395 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 805374..807395 Escherichia coli SMS-3-5 6145228 YP_001742883.1 CDS EcSMS35_0803 NC_010498.1 807433 808341 R identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; hypothetical protein complement(807433..808341) Escherichia coli SMS-3-5 6146495 YP_001742884.1 CDS moaA NC_010498.1 808738 809727 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 808738..809727 Escherichia coli SMS-3-5 6143236 YP_001742885.1 CDS moaB NC_010498.1 809749 810261 D identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR02667; molybdenum cofactor biosynthesis protein B 809749..810261 Escherichia coli SMS-3-5 6146540 YP_001742886.1 CDS moaC NC_010498.1 810264 810749 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 810264..810749 Escherichia coli SMS-3-5 6142881 YP_001742887.1 CDS moaD NC_010498.1 810742 810987 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 810742..810987 Escherichia coli SMS-3-5 6147360 YP_001742888.1 CDS moaE NC_010498.1 810989 811441 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 810989..811441 Escherichia coli SMS-3-5 6143096 YP_001742889.1 CDS EcSMS35_0809 NC_010498.1 811578 812282 D identified by match to protein family HMM PF01027; hypothetical protein 811578..812282 Escherichia coli SMS-3-5 6143897 YP_001742890.1 CDS EcSMS35_0810 NC_010498.1 812489 813202 D identified by match to protein family HMM PF01027; hypothetical protein 812489..813202 Escherichia coli SMS-3-5 6145111 YP_001742891.1 CDS EcSMS35_0811 NC_010498.1 813238 814194 R hypothetical protein complement(813238..814194) Escherichia coli SMS-3-5 6145769 YP_001742892.1 CDS EcSMS35_0812 NC_010498.1 814194 815435 R identified by match to protein family HMM PF00614; cardiolipin synthase 2 complement(814194..815435) Escherichia coli SMS-3-5 6146487 YP_001742893.1 CDS EcSMS35_0813 NC_010498.1 815432 816193 R identified by match to protein family HMM PF03372; endonuclease/exonuclease/phosphatase family protein complement(815432..816193) Escherichia coli SMS-3-5 6147143 YP_001742894.1 CDS EcSMS35_0815 NC_010498.1 816326 816736 D hypothetical protein 816326..816736 Escherichia coli SMS-3-5 6143395 YP_001742895.1 CDS EcSMS35_0814 NC_010498.1 816698 817804 R identified by match to protein family HMM PF01061; ABC-2 type transporter, permease complement(816698..817804) Escherichia coli SMS-3-5 6146348 YP_001742896.1 CDS EcSMS35_0816 NC_010498.1 817815 818948 R identified by match to protein family HMM PF01061; ABC-2 type transporter, permease complement(817815..818948) Escherichia coli SMS-3-5 6143129 YP_001742897.1 CDS EcSMS35_0817 NC_010498.1 818941 820677 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(818941..820677) Escherichia coli SMS-3-5 6144028 YP_001742898.1 CDS EcSMS35_0818 NC_010498.1 820670 821665 R identified by match to protein family HMM PF00529; hypothetical protein complement(820670..821665) Escherichia coli SMS-3-5 6144704 YP_001742899.1 CDS EcSMS35_0819 NC_010498.1 821668 822339 R identified by match to protein family HMM PF00440; match to protein family HMM PF09209; putative DNA-binding transcriptional regulator complement(821668..822339) Escherichia coli SMS-3-5 6147264 YP_001742900.1 CDS EcSMS35_0820 NC_010498.1 822568 823932 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 822568..823932 Escherichia coli SMS-3-5 6145501 YP_001742901.1 CDS EcSMS35_0821 NC_010498.1 824089 824529 D RelB/DinJ family addiction module antitoxin 824089..824529 Escherichia coli SMS-3-5 6143002 YP_001742902.1 CDS EcSMS35_0822 NC_010498.1 824529 824810 D identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; RelE/ParE family addiction module toxin 824529..824810 Escherichia coli SMS-3-5 6146306 YP_001742903.1 CDS dinG NC_010498.1 824981 827131 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 824981..827131 Escherichia coli SMS-3-5 6147507 YP_001742904.1 CDS EcSMS35_0824 NC_010498.1 827159 828121 D identified by match to protein family HMM PF02885; glycosyl transferase family protein 827159..828121 Escherichia coli SMS-3-5 6143282 YP_001742905.1 CDS EcSMS35_0825 NC_010498.1 828262 829347 D identified by match to protein family HMM PF02615; hypothetical protein 828262..829347 Escherichia coli SMS-3-5 6146484 YP_001742906.1 CDS EcSMS35_0826 NC_010498.1 829487 829747 R identified by match to protein family HMM PF07338; hypothetical protein complement(829487..829747) Escherichia coli SMS-3-5 6147172 YP_001742907.1 CDS EcSMS35_0827 NC_010498.1 830012 830278 R identified by match to protein family HMM PF01258; match to protein family HMM TIGR02419; hypothetical protein complement(830012..830278) Escherichia coli SMS-3-5 6142861 YP_001742908.1 CDS EcSMS35_0828 NC_010498.1 830352 831029 R identified by match to protein family HMM PF03171; putative hydroxylase complement(830352..831029) Escherichia coli SMS-3-5 6143565 YP_001742909.1 CDS fiu NC_010498.1 831071 833353 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(831071..833353) Escherichia coli SMS-3-5 6145497 YP_001742910.1 CDS EcSMS35_0830 NC_010498.1 833618 833878 R identified by match to protein family HMM PF07338; hypothetical protein complement(833618..833878) Escherichia coli SMS-3-5 6145854 YP_001742911.1 CDS EcSMS35_0832 NC_010498.1 834154 835080 D identified by match to protein family HMM PF05971; putative SAM-dependent methyltransferase 834154..835080 Escherichia coli SMS-3-5 6144227 YP_001742912.1 CDS EcSMS35_0831 NC_010498.1 835077 837302 R identified by match to protein family HMM PF00924; hypothetical protein complement(835077..837302) Escherichia coli SMS-3-5 6143031 YP_001742913.1 CDS glnQ NC_010498.1 837419 838141 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(837419..838141) Escherichia coli SMS-3-5 6144903 YP_001742914.1 CDS glnP NC_010498.1 838138 838797 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(838138..838797) Escherichia coli SMS-3-5 6146242 YP_001742915.1 CDS glnH NC_010498.1 838936 839682 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(838936..839682) Escherichia coli SMS-3-5 6142928 YP_001742916.1 CDS dps NC_010498.1 840086 840589 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(840086..840589) Escherichia coli SMS-3-5 6144665 YP_001742917.1 CDS rhtA NC_010498.1 840889 841776 R identified by match to protein family HMM PF00892; threonine and homoserine efflux system complement(840889..841776) Escherichia coli SMS-3-5 6146204 YP_001742918.1 CDS ompX NC_010498.1 842129 842644 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 842129..842644 Escherichia coli SMS-3-5 6143572 YP_001742919.1 CDS EcSMS35_0839 NC_010498.1 842693 844276 R identified by match to protein family HMM PF00884; sulfatase family protein complement(842693..844276) Escherichia coli SMS-3-5 6145737 YP_001742920.1 CDS EcSMS35_0840 NC_010498.1 844548 844676 R hypothetical protein complement(844548..844676) Escherichia coli SMS-3-5 6145075 YP_001742921.1 CDS mntR NC_010498.1 844862 845329 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 844862..845329 Escherichia coli SMS-3-5 6144450 YP_001742922.1 CDS EcSMS35_0842 NC_010498.1 845326 846444 D identified by match to protein family HMM PF03600; citrate transporter family protein 845326..846444 Escherichia coli SMS-3-5 6143800 YP_001742923.1 CDS ybiS NC_010498.1 846503 847423 R identified by match to protein family HMM PF03734; hypothetical protein complement(846503..847423) Escherichia coli SMS-3-5 6142612 YP_001742924.1 CDS EcSMS35_0844 NC_010498.1 847642 849234 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 847642..849234 Escherichia coli SMS-3-5 6142991 YP_001742925.1 CDS EcSMS35_0845 NC_010498.1 849307 849426 D identified by Glimmer3; putative; hypothetical protein 849307..849426 Escherichia coli SMS-3-5 6146124 YP_001742926.1 CDS EcSMS35_0846 NC_010498.1 849475 850740 R identified by match to protein family HMM PF07350; hypothetical protein complement(849475..850740) Escherichia coli SMS-3-5 6146036 YP_001742927.1 CDS supH NC_010498.1 850892 851707 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; sugar phosphatase SupH complement(850892..851707) Escherichia coli SMS-3-5 6142842 YP_001742928.1 CDS EcSMS35_0848 NC_010498.1 851853 854285 R identified by similarity to SP:P75793; match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; formate C-acetyltransferase 3 complement(851853..854285) Escherichia coli SMS-3-5 6147098 YP_001742929.1 CDS EcSMS35_0849 NC_010498.1 854291 855190 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; glycyl-radical activating family protein complement(854291..855190) Escherichia coli SMS-3-5 6144575 YP_001742930.1 CDS fsaA NC_010498.1 855321 855983 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 855321..855983 Escherichia coli SMS-3-5 6143297 YP_001742931.1 CDS moeB NC_010498.1 856059 856808 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(856059..856808) Escherichia coli SMS-3-5 6145592 YP_001742932.1 CDS moeA NC_010498.1 856808 858043 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(856808..858043) Escherichia coli SMS-3-5 6145071 YP_001742933.1 CDS EcSMS35_0853 NC_010498.1 858247 859212 D identified by match to protein family HMM PF01112; L-asparaginase 858247..859212 Escherichia coli SMS-3-5 6146091 YP_001742934.1 CDS gsiA NC_010498.1 859199 861070 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 859199..861070 Escherichia coli SMS-3-5 6145406 YP_001742935.1 CDS gsiB NC_010498.1 861090 862628 D identified by match to protein family HMM PF00496; glutathione ABC transporter periplasmic glutathione-binding protein GsiB 861090..862628 Escherichia coli SMS-3-5 6144614 YP_001742936.1 CDS gsiC NC_010498.1 862646 863566 D identified by match to protein family HMM PF00528; glutathione ABC transporter permease GsiC 862646..863566 Escherichia coli SMS-3-5 6144431 YP_001742937.1 CDS gsiD NC_010498.1 863569 864480 D identified by match to protein family HMM PF00528; glutathione ABC transporter permease GsiD 863569..864480 Escherichia coli SMS-3-5 6146137 YP_001742938.1 CDS EcSMS35_0858 NC_010498.1 864657 867005 D identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 864657..867005 Escherichia coli SMS-3-5 6146660 YP_001742939.1 CDS EcSMS35_0859 NC_010498.1 867115 868341 D identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 867115..868341 Escherichia coli SMS-3-5 6146136 YP_001742940.1 CDS EcSMS35_0860 NC_010498.1 868411 868740 R identified by match to protein family HMM PF01381; DNA-binding protein complement(868411..868740) Escherichia coli SMS-3-5 6146831 YP_001742941.1 CDS EcSMS35_0861 NC_010498.1 868730 869116 R identified by match to protein family HMM PF06296; hypothetical protein complement(868730..869116) Escherichia coli SMS-3-5 6147518 YP_001742942.1 CDS rimO NC_010498.1 869342 870667 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase complement(869342..870667) Escherichia coli SMS-3-5 6143268 YP_001742943.1 CDS bssR NC_010498.1 870880 871263 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 870880..871263 Escherichia coli SMS-3-5 6144099 YP_001742944.1 CDS EcSMS35_0865 NC_010498.1 871374 872489 D identified by match to protein family HMM PF07995; glucose / sorbosone dehydrogenase protein 871374..872489 Escherichia coli SMS-3-5 6143865 YP_001742945.1 CDS EcSMS35_0864 NC_010498.1 872486 873112 R identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathione S-transferase family protein complement(872486..873112) Escherichia coli SMS-3-5 6144149 YP_001742946.1 CDS dacC NC_010498.1 873350 874561 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 873350..874561 Escherichia coli SMS-3-5 6144628 YP_001742947.1 CDS deoR NC_010498.1 874608 875366 R identified by match to protein family HMM PF00455; match to protein family HMM PF08220; DNA-binding transcriptional repressor DeoR complement(874608..875366) Escherichia coli SMS-3-5 6145988 YP_001742948.1 CDS EcSMS35_0868 NC_010498.1 875424 876020 R ybjG; identified by similarity to SP:P75806; match to protein family HMM PF01569; undecaprenyl pyrophosphate phosphatase complement(875424..876020) Escherichia coli SMS-3-5 6145007 YP_001742949.1 CDS mdfA NC_010498.1 876305 877537 D identified by match to protein family HMM PF07690; multidrug translocase MdfA 876305..877537 Escherichia coli SMS-3-5 6146383 YP_001742950.1 CDS EcSMS35_0870 NC_010498.1 877578 877856 R hypothetical protein complement(877578..877856) Escherichia coli SMS-3-5 6145689 YP_001742951.1 CDS ybjI NC_010498.1 877948 878763 R identified by match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YbjI complement(877948..878763) Escherichia coli SMS-3-5 6147160 YP_001742952.1 CDS EcSMS35_0872 NC_010498.1 878763 879971 R identified by match to protein family HMM PF07690; major facilitator transporter complement(878763..879971) Escherichia coli SMS-3-5 6146471 YP_001742953.1 CDS EcSMS35_0873 NC_010498.1 880055 880591 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 880055..880591 Escherichia coli SMS-3-5 6144101 YP_001742954.1 CDS EcSMS35_0874 NC_010498.1 880766 882451 R identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625; hypothetical protein complement(880766..882451) Escherichia coli SMS-3-5 6143591 YP_001742955.1 CDS EcSMS35_0875 NC_010498.1 882721 883098 D hypothetical protein 882721..883098 Escherichia coli SMS-3-5 6147350 YP_001742956.1 CDS grxA NC_010498.1 883128 883385 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 complement(883128..883385) Escherichia coli SMS-3-5 6146966 YP_001742957.1 CDS EcSMS35_0877 NC_010498.1 883545 883832 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 883545..883832 Escherichia coli SMS-3-5 6144899 YP_001742958.1 CDS nfsA NC_010498.1 883816 884538 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 883816..884538 Escherichia coli SMS-3-5 6144207 YP_001742959.1 CDS rimK NC_010498.1 884599 885501 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 884599..885501 Escherichia coli SMS-3-5 6145951 YP_001742960.1 CDS EcSMS35_0880 NC_010498.1 885589 886065 D TPR repeat-containing protein 885589..886065 Escherichia coli SMS-3-5 6145225 YP_001742961.1 CDS EcSMS35_0881 NC_010498.1 886022 886144 D identified by Glimmer3; putative; hypothetical protein 886022..886144 Escherichia coli SMS-3-5 6146986 YP_001742962.1 CDS potF NC_010498.1 886416 887528 D identified by match to protein family HMM PF01547; putrescine transporter subunit: periplasmic-binding component of ABC superfamily 886416..887528 Escherichia coli SMS-3-5 6146448 YP_001742963.1 CDS potG NC_010498.1 887623 888756 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 887623..888756 Escherichia coli SMS-3-5 6146764 YP_001742964.1 CDS potH NC_010498.1 888766 889719 D identified by match to protein family HMM PF00528; putrescine transporter subunit: membrane component of ABC superfamily 888766..889719 Escherichia coli SMS-3-5 6146223 YP_001742965.1 CDS potI NC_010498.1 889716 890561 D identified by match to protein family HMM PF00528; putrescine transporter subunit: membrane component of ABC superfamily 889716..890561 Escherichia coli SMS-3-5 6143439 YP_001742966.1 CDS EcSMS35_0886 NC_010498.1 890621 891109 D hypothetical protein 890621..891109 Escherichia coli SMS-3-5 6146478 YP_001742967.1 CDS rumB NC_010498.1 891150 892277 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 891150..892277 Escherichia coli SMS-3-5 6145152 YP_001742968.1 CDS artJ NC_010498.1 892306 893037 R identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; arginine ABC transporter periplasmic arginine-binding protein ArtJ complement(892306..893037) Escherichia coli SMS-3-5 6145655 YP_001742969.1 CDS artM NC_010498.1 893263 893931 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(893263..893931) Escherichia coli SMS-3-5 6145676 YP_001742970.1 CDS artQ NC_010498.1 893931 894647 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(893931..894647) Escherichia coli SMS-3-5 6143849 YP_001742971.1 CDS artI NC_010498.1 894654 895385 R identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; arginine ABC transporter periplasmic arginine-binding protein ArtI complement(894654..895385) Escherichia coli SMS-3-5 6144850 YP_001742972.1 CDS artP NC_010498.1 895403 896131 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(895403..896131) Escherichia coli SMS-3-5 6142910 YP_001742973.1 CDS EcSMS35_0893 NC_010498.1 896349 896864 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; putative lipoprotein complement(896349..896864) Escherichia coli SMS-3-5 6146459 YP_001742974.1 CDS EcSMS35_0894 NC_010498.1 897479 899281 D hypothetical protein 897479..899281 Escherichia coli SMS-3-5 6147155 YP_001742975.1 CDS EcSMS35_0895 NC_010498.1 899492 899815 D identified by match to protein family HMM PF01906; hypothetical protein 899492..899815 Escherichia coli SMS-3-5 6143139 YP_001742976.1 CDS amiD NC_010498.1 899812 900642 D identified by similarity to SP:P75820; match to protein family HMM PF01510; N-acetylmuramoyl-L-alanine amidase AmiD 899812..900642 Escherichia coli SMS-3-5 6147397 YP_001742977.1 CDS EcSMS35_0896 NC_010498.1 900639 901688 R identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; NAD-dependent epimerase/dehydratase family protein complement(900639..901688) Escherichia coli SMS-3-5 6146277 YP_001742978.1 CDS EcSMS35_0898 NC_010498.1 901751 903181 R identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368; NAD dependent epimerase/dehydratase family protein complement(901751..903181) Escherichia coli SMS-3-5 6147021 YP_001742979.1 CDS ltaE NC_010498.1 903192 904193 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(903192..904193) Escherichia coli SMS-3-5 6145197 YP_001742980.1 CDS poxB NC_010498.1 904230 905948 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(904230..905948) Escherichia coli SMS-3-5 6145667 YP_001742981.1 CDS hcr NC_010498.1 906081 907049 R identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; HCP oxidoreductase, NADH-dependent complement(906081..907049) Escherichia coli SMS-3-5 6143830 YP_001742982.1 CDS hcp NC_010498.1 907061 908713 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(907061..908713) Escherichia coli SMS-3-5 6142977 YP_001742983.1 CDS EcSMS35_0903 NC_010498.1 908857 909756 R identified by match to protein family HMM PF03956; hypothetical protein complement(908857..909756) Escherichia coli SMS-3-5 6142963 YP_001742984.1 CDS EcSMS35_0904 NC_010498.1 910096 911121 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS110 family transposase 910096..911121 Escherichia coli SMS-3-5 6143518 YP_001742985.1 CDS EcSMS35_0905 NC_010498.1 911930 913366 D may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 911930..913366 Escherichia coli SMS-3-5 6145937 YP_001742986.1 CDS EcSMS35_0906 NC_010498.1 913419 914180 D identified by match to protein family HMM PF00106; acetoin dehydrogenase 913419..914180 Escherichia coli SMS-3-5 6145256 YP_001742987.1 CDS EcSMS35_0908 NC_010498.1 914190 914309 D identified by Glimmer3; putative; hypothetical protein 914190..914309 Escherichia coli SMS-3-5 6144946 YP_001742988.1 CDS EcSMS35_0907 NC_010498.1 914300 914878 R identified by match to protein family HMM PF09335; hypothetical protein complement(914300..914878) Escherichia coli SMS-3-5 6142671 YP_001742989.1 CDS EcSMS35_0909 NC_010498.1 915048 915635 D identified by match to protein family HMM PF06930; hypothetical protein 915048..915635 Escherichia coli SMS-3-5 6146976 YP_001742990.1 CDS pbpG NC_010498.1 915800 916741 D specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 915800..916741 Escherichia coli SMS-3-5 6144390 YP_001742991.1 CDS dld NC_010498.1 916780 918495 R component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase complement(916780..918495) Escherichia coli SMS-3-5 6144145 YP_001742992.1 CDS bglX NC_010498.1 918691 920988 D identified by match to protein family HMM PF00933; match to protein family HMM PF01915; beta-glucosidase, periplasmic 918691..920988 Escherichia coli SMS-3-5 6145851 YP_001742993.1 CDS EcSMS35_0913 NC_010498.1 921240 922157 D identified by match to protein family HMM PF04069; quaternary amine ABC transporter periplasmic substrate-binding protein 921240..922157 Escherichia coli SMS-3-5 6145239 YP_001742994.1 CDS EcSMS35_0914 NC_010498.1 922164 923321 D identified by match to protein family HMM PF00528; quaternary amine ABC transporter permease 922164..923321 Escherichia coli SMS-3-5 6147226 YP_001742995.1 CDS EcSMS35_0915 NC_010498.1 923314 924240 D identified by match to protein family HMM PF00005; quaternary amine ABC transporter ATP-binding protein 923314..924240 Escherichia coli SMS-3-5 6147103 YP_001742996.1 CDS EcSMS35_0916 NC_010498.1 924245 924976 D identified by match to protein family HMM PF00528; quaternary amine ABC transporter permease 924245..924976 Escherichia coli SMS-3-5 6143503 YP_001742997.1 CDS EcSMS35_0917 NC_010498.1 925124 925855 R identified by similarity to SP:P33358; match to protein family HMM PF00376; transcriptional regulator MlrA complement(925124..925855) Escherichia coli SMS-3-5 6144355 YP_001742998.1 CDS EcSMS35_0918 NC_010498.1 926077 927762 D identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF06580; match to protein family HMM PF07694; sensor histidine kinase 926077..927762 Escherichia coli SMS-3-5 6145172 YP_001742999.1 CDS EcSMS35_0919 NC_010498.1 927759 928478 D unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT 927759..928478 Escherichia coli SMS-3-5 6145710 YP_001743000.1 CDS EcSMS35_0920 NC_010498.1 928525 928995 D identified by match to protein family HMM PF07308; hypothetical protein 928525..928995 Escherichia coli SMS-3-5 6145686 YP_001743001.1 CDS EcSMS35_0921 NC_010498.1 929036 929497 R identified by match to protein family HMM PF06998; putative lipoprotein complement(929036..929497) Escherichia coli SMS-3-5 6146549 YP_001743002.1 CDS EcSMS35_0922 NC_010498.1 929622 931622 R identified by match to protein family HMM PF04434; hypothetical protein complement(929622..931622) Escherichia coli SMS-3-5 6147104 YP_001743003.1 CDS EcSMS35_0923 NC_010498.1 931619 932755 R identified by match to protein family HMM PF00092; match to protein family HMM PF05762; von Willebrand factor type A domain-containing protein complement(931619..932755) Escherichia coli SMS-3-5 6142854 YP_001743004.1 CDS EcSMS35_0924 NC_010498.1 932748 935027 R hypothetical protein complement(932748..935027) Escherichia coli SMS-3-5 6142862 YP_001743005.1 CDS EcSMS35_0925 NC_010498.1 935038 936126 R identified by match to protein family HMM PF07728; AAA family ATPase complement(935038..936126) Escherichia coli SMS-3-5 6143562 YP_001743006.1 CDS EcSMS35_0926 NC_010498.1 936702 937022 R identified by Glimmer3; putative; hypothetical protein complement(936702..937022) Escherichia coli SMS-3-5 6143257 YP_001743007.1 CDS EcSMS35_0927 NC_010498.1 937083 940745 R molybdate metabolism regulator MolR-like protein complement(937083..940745) Escherichia coli SMS-3-5 6143772 YP_001743008.1 CDS molR NC_010498.1 940755 944543 R identified by similarity to SP:P33345; match to protein family HMM PF05406; molybdate metabolism regulator MolR complement(940755..944543) Escherichia coli SMS-3-5 6144730 YP_001743009.1 CDS metG NC_010498.1 944684 946717 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(944684..946717) Escherichia coli SMS-3-5 6145127 YP_001743010.1 CDS EcSMS35_0930 NC_010498.1 946849 947958 D putative ATPase 946849..947958 Escherichia coli SMS-3-5 6146053 YP_001743011.1 CDS EcSMS35_0931 NC_010498.1 948221 948502 D identified by similarity to GB:AAP17529.1; hypothetical protein 948221..948502 Escherichia coli SMS-3-5 6146431 YP_001743012.1 CDS EcSMS35_0932 NC_010498.1 948798 949340 D identified by match to protein family HMM PF00419; fimbrial protein 948798..949340 Escherichia coli SMS-3-5 6146150 YP_001743013.1 CDS EcSMS35_0934 NC_010498.1 950111 952591 D yehB; identified by match to protein family HMM PF00577; fimbrial usher protein 950111..952591 Escherichia coli SMS-3-5 6142802 YP_001743014.1 CDS EcSMS35_0935 NC_010498.1 952607 953641 D hypothetical protein 952607..953641 Escherichia coli SMS-3-5 6143582 YP_001743015.1 CDS EcSMS35_0936 NC_010498.1 953723 954061 R hypothetical protein complement(953723..954061) Escherichia coli SMS-3-5 6144150 YP_001743016.1 CDS rcnA NC_010498.1 954280 955104 R membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA complement(954280..955104) Escherichia coli SMS-3-5 6143812 YP_001743017.1 CDS rcnR NC_010498.1 955225 955497 D identified by match to protein family HMM PF02583; transcriptional repressor RcnR 955225..955497 Escherichia coli SMS-3-5 6145459 YP_001743018.1 CDS EcSMS35_0939 NC_010498.1 955827 957047 D identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 955827..957047 Escherichia coli SMS-3-5 6145601 YP_001743019.1 CDS EcSMS35_0940 NC_010498.1 957044 957898 D identified by similarity to GB:CAG74537.1; hypothetical protein 957044..957898 Escherichia coli SMS-3-5 6146262 YP_001743020.1 CDS EcSMS35_0941 NC_010498.1 958002 958226 D identified by match to protein family HMM PF05930; AlpA family transcriptional regulator 958002..958226 Escherichia coli SMS-3-5 6147102 YP_001743021.1 CDS EcSMS35_0942 NC_010498.1 958237 959055 D identified by similarity to GB:AAZ87612.1; hypothetical protein 958237..959055 Escherichia coli SMS-3-5 6142667 YP_001743022.1 CDS EcSMS35_0943 NC_010498.1 959075 959278 D identified by Glimmer3; putative; hypothetical protein 959075..959278 Escherichia coli SMS-3-5 6144148 YP_001743023.1 CDS EcSMS35_0944 NC_010498.1 959271 959591 D identified by Glimmer3; putative; hypothetical protein 959271..959591 Escherichia coli SMS-3-5 6144900 YP_001743024.1 CDS EcSMS35_0945 NC_010498.1 959598 959897 D identified by similarity to GB:AAZ87613.1; hypothetical protein 959598..959897 Escherichia coli SMS-3-5 6145376 YP_001743025.1 CDS EcSMS35_0946 NC_010498.1 959894 961711 D identified by match to protein family HMM PF03288; match to protein family HMM PF08706; D5 family nucleoside triphosphatase 959894..961711 Escherichia coli SMS-3-5 6146051 YP_001743026.1 CDS EcSMS35_0947 NC_010498.1 961999 962244 D identified by similarity to GB:AAZ87617.1; hypothetical protein 961999..962244 Escherichia coli SMS-3-5 6144313 YP_001743027.1 CDS EcSMS35_0948 NC_010498.1 962241 962666 D identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621; single-strand binding protein family 962241..962666 Escherichia coli SMS-3-5 6147408 YP_001743028.1 CDS EcSMS35_0949 NC_010498.1 962689 962931 D identified by similarity to GB:ABF03362.1; hypothetical protein 962689..962931 Escherichia coli SMS-3-5 6143015 YP_001743029.1 CDS EcSMS35_0950 NC_010498.1 962967 963473 R hypothetical protein complement(962967..963473) Escherichia coli SMS-3-5 6146370 YP_001743030.1 CDS EcSMS35_0951 NC_010498.1 963760 964929 D identified by match to protein family HMM PF05065; match to protein family HMM TIGR01554; HK97 family phage major capsid protein 963760..964929 Escherichia coli SMS-3-5 6146879 YP_001743031.1 CDS EcSMS35_0952 NC_010498.1 964984 965544 D identified by match to protein family HMM PF04586; match to protein family HMM TIGR01543; HK97 family phage prohead protease 964984..965544 Escherichia coli SMS-3-5 6145323 YP_001743032.1 CDS EcSMS35_0953 NC_010498.1 965546 966760 D identified by match to protein family HMM PF04860; match to protein family HMM TIGR01537; HK97 family phage portal protein 965546..966760 Escherichia coli SMS-3-5 6145949 YP_001743033.1 CDS EcSMS35_0954 NC_010498.1 966753 967055 D identified by match to protein family HMM PF05135; match to protein family HMM TIGR01560; DNA packaging, phage QLRG family protein 966753..967055 Escherichia coli SMS-3-5 6143427 YP_001743034.1 CDS EcSMS35_0955 NC_010498.1 967055 967495 D identified by match to protein family HMM PF01844; HNH endonuclease family protein 967055..967495 Escherichia coli SMS-3-5 6144129 YP_001743035.1 CDS EcSMS35_0956 NC_010498.1 967757 968140 D identified by match to protein family HMM PF05119; match to protein family HMM TIGR01558; P27 family phage terminase small subunit 967757..968140 Escherichia coli SMS-3-5 6144709 YP_001743036.1 CDS EcSMS35_0957 NC_010498.1 968124 969785 D identified by match to protein family HMM PF03354; putative phage terminase, large subunit 968124..969785 Escherichia coli SMS-3-5 6144497 YP_001743037.1 CDS EcSMS35_0958 NC_010498.1 969791 970072 D identified by similarity to RF:NP_836846.1; hypothetical protein 969791..970072 Escherichia coli SMS-3-5 6142648 YP_001743038.1 CDS EcSMS35_0959 NC_010498.1 970562 970723 R identified by Glimmer3; putative; hypothetical protein complement(970562..970723) Escherichia coli SMS-3-5 6143020 YP_001743039.1 CDS thiM NC_010498.1 970862 971650 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 970862..971650 Escherichia coli SMS-3-5 6146207 YP_001743040.1 CDS thiD NC_010498.1 971647 972447 D catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 971647..972447 Escherichia coli SMS-3-5 6147211 YP_001743041.1 CDS EcSMS35_0962 NC_010498.1 972512 973330 D identified by match to protein family HMM PF01183; glycosyl hydrolase family protein 972512..973330 Escherichia coli SMS-3-5 6145243 YP_001743042.1 CDS EcSMS35_0964 NC_010498.1 973382 974128 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM PF08279; GntR family transcriptional regulator 973382..974128 Escherichia coli SMS-3-5 6145845 YP_001743043.1 CDS EcSMS35_0963 NC_010498.1 974102 975067 R identified by match to protein family HMM PF00294; PfkB family kinase complement(974102..975067) Escherichia coli SMS-3-5 6145827 YP_001743044.1 CDS EcSMS35_0965 NC_010498.1 975064 976068 R identified by match to protein family HMM PF03747; ADP-ribosylglycohydrolase family protein complement(975064..976068) Escherichia coli SMS-3-5 6143048 YP_001743045.1 CDS yegT NC_010498.1 976065 977342 R identified by match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; nucleoside transporter complement(976065..977342) Escherichia coli SMS-3-5 6145336 YP_001743046.1 CDS fbaB NC_010498.1 977599 978651 D catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 977599..978651 Escherichia coli SMS-3-5 6144788 YP_001743047.1 CDS gatY NC_010498.1 978880 979734 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 978880..979734 Escherichia coli SMS-3-5 6144270 YP_001743048.1 CDS EcSMS35_0969 NC_010498.1 979763 981025 D identified by match to protein family HMM PF08013; match to protein family HMM TIGR02810; putative tagatose-6-phosphate kinase 979763..981025 Escherichia coli SMS-3-5 6145820 YP_001743049.1 CDS gatA NC_010498.1 981035 981487 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 981035..981487 Escherichia coli SMS-3-5 6145319 YP_001743050.1 CDS gatB NC_010498.1 981518 981802 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 981518..981802 Escherichia coli SMS-3-5 6144812 YP_001743051.1 CDS gatC NC_010498.1 981806 983161 D identified by match to protein family HMM PF03611; match to protein family HMM TIGR00827; PTS system, galactitol-specific IIC component 981806..983161 Escherichia coli SMS-3-5 6144264 YP_001743052.1 CDS gatD NC_010498.1 983209 984249 D Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 983209..984249 Escherichia coli SMS-3-5 6142996 YP_001743053.1 CDS gatR NC_010498.1 984349 985128 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; galactitol utilization operon repressor 984349..985128 Escherichia coli SMS-3-5 6144532 YP_001743054.1 CDS EcSMS35_0975 NC_010498.1 985210 986109 R cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase complement(985210..986109) Escherichia coli SMS-3-5 6146203 YP_001743055.1 CDS EcSMS35_0976 NC_010498.1 986564 986839 D hypothetical protein 986564..986839 Escherichia coli SMS-3-5 6143025 YP_001743056.1 CDS EcSMS35_0977 NC_010498.1 987169 988530 R identified by match to protein family HMM PF01136; U32 family peptidase complement(987169..988530) Escherichia coli SMS-3-5 6146059 YP_001743057.1 CDS EcSMS35_0978 NC_010498.1 988633 988929 R identified by match to protein family HMM PF05016; RelE/ParE family plasmid stabilization system protein complement(988633..988929) Escherichia coli SMS-3-5 6145398 YP_001743058.1 CDS EcSMS35_0979 NC_010498.1 988931 989182 R identified by match to protein family HMM PF01402; match to protein family HMM PF03693; match to protein family HMM TIGR02606; CC2985 family addiction module antidote protein complement(988931..989182) Escherichia coli SMS-3-5 6147149 YP_001743059.1 CDS EcSMS35_0980 NC_010498.1 989436 989768 R identified by match to protein family HMM PF07411; hypothetical protein complement(989436..989768) Escherichia coli SMS-3-5 6146477 YP_001743060.1 CDS baeR NC_010498.1 989948 990670 R response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR complement(989948..990670) Escherichia coli SMS-3-5 6145148 YP_001743061.1 CDS baeS NC_010498.1 990667 992070 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; signal transduction histidine-protein kinase BaeS complement(990667..992070) Escherichia coli SMS-3-5 6144504 YP_001743062.1 CDS mdtD NC_010498.1 992067 993482 R identified by match to protein family HMM PF07690; multidrug efflux system protein MdtE complement(992067..993482) Escherichia coli SMS-3-5 6144223 YP_001743063.1 CDS mdtC NC_010498.1 993483 996560 R Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC complement(993483..996560) Escherichia coli SMS-3-5 6147028 YP_001743064.1 CDS mdtB NC_010498.1 996561 999683 R Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB complement(996561..999683) Escherichia coli SMS-3-5 6144167 YP_001743065.1 CDS mdtA NC_010498.1 999683 1000930 R Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA complement(999683..1000930) Escherichia coli SMS-3-5 6144829 YP_001743066.1 CDS EcSMS35_0987 NC_010498.1 1001819 1002478 D identified by match to protein family HMM PF00092; von Willebrand factor type A domain-containing protein 1001819..1002478 Escherichia coli SMS-3-5 6143256 YP_001743067.1 CDS EcSMS35_0988 NC_010498.1 1002556 1003236 D hypothetical protein 1002556..1003236 Escherichia coli SMS-3-5 6143873 YP_001743068.1 CDS EcSMS35_0989 NC_010498.1 1003301 1003822 R identified by Glimmer3; putative; hypothetical protein complement(1003301..1003822) Escherichia coli SMS-3-5 6146228 YP_001743069.1 CDS EcSMS35_0990 NC_010498.1 1003964 1005910 D hypothetical protein 1003964..1005910 Escherichia coli SMS-3-5 6146757 YP_001743070.1 CDS EcSMS35_0991 NC_010498.1 1005923 1007275 R putative chaperone complement(1005923..1007275) Escherichia coli SMS-3-5 6145469 YP_001743071.1 CDS alkA NC_010498.1 1007409 1008257 D inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II 1007409..1008257 Escherichia coli SMS-3-5 6145992 YP_001743072.1 CDS EcSMS35_0993 NC_010498.1 1008367 1011684 R contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein complement(1008367..1011684) Escherichia coli SMS-3-5 6146501 YP_001743073.1 CDS udk NC_010498.1 1012002 1012643 D functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1012002..1012643 Escherichia coli SMS-3-5 6146575 YP_001743074.1 CDS dcd NC_010498.1 1012735 1013316 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1012735..1013316 Escherichia coli SMS-3-5 6144220 YP_001743075.1 CDS asmA NC_010498.1 1013338 1015191 D YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein 1013338..1015191 Escherichia coli SMS-3-5 6143404 YP_001743076.1 CDS EcSMS35_0997 NC_010498.1 1015243 1015533 R identified by match to protein family HMM PF01381; putative DNA-binding protein complement(1015243..1015533) Escherichia coli SMS-3-5 6145224 YP_001743077.1 CDS EcSMS35_0998 NC_010498.1 1015523 1015744 R identified by match to protein family HMM PF05973; hypothetical protein complement(1015523..1015744) Escherichia coli SMS-3-5 6144699 YP_001743078.1 CDS EcSMS35_0999 NC_010498.1 1016082 1017665 R identified by match to protein family HMM PF00571; match to protein family HMM PF03471; match to protein family HMM PF03741; TerC family/CBS/transporter associated domain-containing protein complement(1016082..1017665) Escherichia coli SMS-3-5 6146943 YP_001743079.1 CDS EcSMS35_1000 NC_010498.1 1018324 1019463 D identified by match to protein family HMM PF02563; polysaccharide biosynthesis/export protein 1018324..1019463 Escherichia coli SMS-3-5 6146395 YP_001743080.1 CDS wzb NC_010498.1 1019469 1019912 D Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 1019469..1019912 Escherichia coli SMS-3-5 6143062 YP_001743081.1 CDS wzc NC_010498.1 1019915 1022077 D Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 1019915..1022077 Escherichia coli SMS-3-5 6147421 YP_001743082.1 CDS wcaA NC_010498.1 1022169 1023008 D identified by match to protein family HMM PF00535; putative glycosyl transferase 1022169..1023008 Escherichia coli SMS-3-5 6145290 YP_001743083.1 CDS EcSMS35_1004 NC_010498.1 1023011 1023499 D acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB 1023011..1023499 Escherichia coli SMS-3-5 6145815 YP_001743084.1 CDS wcaC NC_010498.1 1023496 1024713 D putative glycosyl transferase 1023496..1024713 Escherichia coli SMS-3-5 6146381 YP_001743085.1 CDS wcaD NC_010498.1 1024688 1025905 D essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein 1024688..1025905 Escherichia coli SMS-3-5 6146928 YP_001743086.1 CDS wcaE NC_010498.1 1025916 1026662 D identified by match to protein family HMM PF00535; putative glycosyl transferase 1025916..1026662 Escherichia coli SMS-3-5 6147439 YP_001743087.1 CDS EcSMS35_1008 NC_010498.1 1026678 1027226 D acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF 1026678..1027226 Escherichia coli SMS-3-5 6143043 YP_001743088.1 CDS gmd NC_010498.1 1027253 1028374 D identified by match to protein family HMM PF01370; match to protein family HMM TIGR01472; GDP-mannose 4,6-dehydratase 1027253..1028374 Escherichia coli SMS-3-5 6145928 YP_001743089.1 CDS fcl NC_010498.1 1028377 1029342 D identified by match to protein family HMM PF01370; match to protein family HMM PF04321; GDP-L-fucose synthetase 1028377..1029342 Escherichia coli SMS-3-5 6144256 YP_001743090.1 CDS nudD NC_010498.1 1029345 1029824 D identified by match to protein family HMM PF00293; GDP-mannose mannosyl hydrolase 1029345..1029824 Escherichia coli SMS-3-5 6146413 YP_001743091.1 CDS wcaI NC_010498.1 1029821 1031044 D identified by match to protein family HMM PF00534; putative glycosyl transferase 1029821..1031044 Escherichia coli SMS-3-5 6146917 YP_001743092.1 CDS cpsB NC_010498.1 1031047 1032483 D identified by similarity to SP:P24174; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; mannose-1-phosphate guanylyltransferase 1031047..1032483 Escherichia coli SMS-3-5 6143034 YP_001743093.1 CDS cpsG NC_010498.1 1032585 1033955 D identified by similarity to SP:P24175; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphomannomutase 1032585..1033955 Escherichia coli SMS-3-5 6146790 YP_001743094.1 CDS EcSMS35_1015 NC_010498.1 1034010 1035404 D WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase 1034010..1035404 Escherichia coli SMS-3-5 6147317 YP_001743095.1 CDS wzxC NC_010498.1 1035406 1036884 D identified by match to protein family HMM PF01943; colanic acid exporter 1035406..1036884 Escherichia coli SMS-3-5 6146636 YP_001743096.1 CDS wcaK NC_010498.1 1036956 1038236 D identified by match to protein family HMM PF04230; putative pyruvyl transferase 1036956..1038236 Escherichia coli SMS-3-5 6145929 YP_001743097.1 CDS wcaL NC_010498.1 1038233 1039453 D identified by match to protein family HMM PF00534; colanic acid biosynthesis glycosyl transferase WcaL 1038233..1039453 Escherichia coli SMS-3-5 6142712 YP_001743098.1 CDS wcaM NC_010498.1 1039464 1040858 D WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein 1039464..1040858 Escherichia coli SMS-3-5 6146961 YP_001743099.1 CDS gne NC_010498.1 1041016 1042011 D identified by similarity to SP:Q8X7P7; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; UDP-N-acetylglucosamine 4-epimerase 1041016..1042011 Escherichia coli SMS-3-5 6143898 YP_001743100.1 CDS galF NC_010498.1 1042254 1043147 D together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 1042254..1043147 Escherichia coli SMS-3-5 6143064 YP_001743101.1 CDS EcSMS35_1022 NC_010498.1 1043457 1044278 D identified by match to protein family HMM PF00535; glycosyl transferase, group 2 1043457..1044278 Escherichia coli SMS-3-5 6144887 YP_001743102.1 CDS EcSMS35_1023 NC_010498.1 1044280 1046046 D identified by Glimmer3; putative; hypothetical protein 1044280..1046046 Escherichia coli SMS-3-5 6144192 YP_001743103.1 CDS EcSMS35_1024 NC_010498.1 1046050 1046922 D identified by match to protein family HMM PF00535; glycosyl transferase, group 2 1046050..1046922 Escherichia coli SMS-3-5 6143837 YP_001743104.1 CDS EcSMS35_1025 NC_010498.1 1046922 1048100 D hypothetical protein 1046922..1048100 Escherichia coli SMS-3-5 6145534 YP_001743105.1 CDS EcSMS35_1026 NC_010498.1 1048051 1049076 D identified by match to protein family HMM PF00534; glycosyl transferase, group 1 1048051..1049076 Escherichia coli SMS-3-5 6147290 YP_001743106.1 CDS EcSMS35_1027 NC_010498.1 1049057 1050235 D identified by match to protein family HMM PF01943; putative polysaccharide biosynthesis protein 1049057..1050235 Escherichia coli SMS-3-5 6146594 YP_001743107.1 CDS EcSMS35_1028 NC_010498.1 1050258 1050698 D hypothetical protein 1050258..1050698 Escherichia coli SMS-3-5 6146644 YP_001743108.1 CDS EcSMS35_1029 NC_010498.1 1050720 1050932 D IS1 transposase orfA 1050720..1050932 Escherichia coli SMS-3-5 6147239 YP_001743109.1 CDS EcSMS35_1030 NC_010498.1 1050943 1051446 D identified by match to protein family HMM PF03400; IS1 transposase orfB 1050943..1051446 Escherichia coli SMS-3-5 6143430 YP_001743110.1 CDS gnd NC_010498.1 1051833 1053239 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1051833..1053239 Escherichia coli SMS-3-5 6143451 YP_001743111.1 CDS ugd NC_010498.1 1053487 1054653 D identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 1053487..1054653 Escherichia coli SMS-3-5 6142746 YP_001743112.1 CDS EcSMS35_1033 NC_010498.1 1054799 1055779 D identified by match to protein family HMM PF02706; chain length determinant protein 1054799..1055779 Escherichia coli SMS-3-5 6144602 YP_001743113.1 CDS hisIE NC_010498.1 1055875 1056486 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein complement(1055875..1056486) Escherichia coli SMS-3-5 6144618 YP_001743114.1 CDS hisF NC_010498.1 1056480 1057256 R catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF complement(1056480..1057256) Escherichia coli SMS-3-5 6143904 YP_001743115.1 CDS hisA NC_010498.1 1057238 1057975 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase complement(1057238..1057975) Escherichia coli SMS-3-5 6143881 YP_001743116.1 CDS hisH NC_010498.1 1057975 1058565 R with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH complement(1057975..1058565) Escherichia coli SMS-3-5 6144384 YP_001743117.1 CDS hisB NC_010498.1 1058565 1059632 R catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase complement(1058565..1059632) Escherichia coli SMS-3-5 6144807 YP_001743118.1 CDS hisC NC_010498.1 1059632 1060702 R catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase complement(1059632..1060702) Escherichia coli SMS-3-5 6142706 YP_001743119.1 CDS hisD NC_010498.1 1060699 1062003 R catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase complement(1060699..1062003) Escherichia coli SMS-3-5 6142608 YP_001743120.1 CDS hisG NC_010498.1 1062009 1062908 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(1062009..1062908) Escherichia coli SMS-3-5 6143183 YP_001743121.1 CDS EcSMS35_1042 NC_010498.1 1063273 1063401 D identified by Glimmer3; putative; hypothetical protein 1063273..1063401 Escherichia coli SMS-3-5 6146881 YP_001743122.1 CDS EcSMS35_1043 NC_010498.1 1063531 1064355 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; NAD dependent epimerase/dehydratase family protein 1063531..1064355 Escherichia coli SMS-3-5 6145031 YP_001743123.1 CDS EcSMS35_1044 NC_010498.1 1064401 1065330 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1064401..1065330 Escherichia coli SMS-3-5 6145564 YP_001743124.1 CDS yeeF NC_010498.1 1065597 1066955 D identified by match to protein family HMM PF00324; amino acid permease 1065597..1066955 Escherichia coli SMS-3-5 6144169 YP_001743125.1 CDS EcSMS35_1046 NC_010498.1 1066986 1067099 D identified by Glimmer3; putative; hypothetical protein 1066986..1067099 Escherichia coli SMS-3-5 6143087 YP_001743126.1 CDS EcSMS35_1047 NC_010498.1 1067134 1068192 D identified by match to protein family HMM PF04143; YeeE/YedE family membrane protein 1067134..1068192 Escherichia coli SMS-3-5 6145361 YP_001743127.1 CDS EcSMS35_1048 NC_010498.1 1068206 1068433 D identified by match to protein family HMM PF01206; hypothetical protein 1068206..1068433 Escherichia coli SMS-3-5 6144668 YP_001743128.1 CDS sbcB NC_010498.1 1068476 1069903 R Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I complement(1068476..1069903) Escherichia coli SMS-3-5 6147212 YP_001743129.1 CDS EcSMS35_1050 NC_010498.1 1070027 1070185 R identified by Glimmer3; putative; hypothetical protein complement(1070027..1070185) Escherichia coli SMS-3-5 6146537 YP_001743130.1 CDS dacD NC_010498.1 1070106 1071278 D removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1070106..1071278 Escherichia coli SMS-3-5 6147385 YP_001743131.1 CDS gyrI NC_010498.1 1071397 1071870 D identified by match to protein family HMM PF06445; DNA gyrase inhibitor 1071397..1071870 Escherichia coli SMS-3-5 6142950 YP_001743132.1 CDS EcSMS35_1054 NC_010498.1 1072068 1073126 D hypothetical protein 1072068..1073126 Escherichia coli SMS-3-5 6144474 YP_001743133.1 CDS EcSMS35_1053 NC_010498.1 1073091 1073207 R identified by Glimmer3; putative; hypothetical protein complement(1073091..1073207) Escherichia coli SMS-3-5 6145792 YP_001743134.1 CDS EcSMS35_1055 NC_010498.1 1073298 1073627 D identified by match to protein family HMM PF04363; hypothetical protein 1073298..1073627 Escherichia coli SMS-3-5 6143735 YP_001743135.1 CDS EcSMS35_1056 NC_010498.1 1073728 1074084 R identified by similarity to SP:Q8X8U4; hypothetical protein complement(1073728..1074084) Escherichia coli SMS-3-5 6147390 YP_001743136.1 CDS EcSMS35_1057 NC_010498.1 1074399 1074512 R hypothetical protein complement(1074399..1074512) Escherichia coli SMS-3-5 6145874 YP_001743137.1 CDS EcSMS35_1058 NC_010498.1 1074525 1074716 R hypothetical protein complement(1074525..1074716) Escherichia coli SMS-3-5 6144300 YP_001743138.1 CDS EcSMS35_1059 NC_010498.1 1074826 1075089 R identified by match to protein family HMM PF06755; hypothetical protein complement(1074826..1075089) Escherichia coli SMS-3-5 6146284 YP_001743139.1 CDS EcSMS35_1060 NC_010498.1 1075178 1075444 R identified by match to protein family HMM PF06154; hypothetical protein complement(1075178..1075444) Escherichia coli SMS-3-5 6145296 YP_001743140.1 CDS EcSMS35_1061 NC_010498.1 1075620 1075841 R identified by match to protein family HMM PF06174; hypothetical protein complement(1075620..1075841) Escherichia coli SMS-3-5 6147427 YP_001743141.1 CDS EcSMS35_1062 NC_010498.1 1075904 1076380 R identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein complement(1075904..1076380) Escherichia coli SMS-3-5 6143006 YP_001743142.1 CDS EcSMS35_1063 NC_010498.1 1076396 1076875 R identified by match to protein family HMM PF03230; antirestriction protein complement(1076396..1076875) Escherichia coli SMS-3-5 6144245 YP_001743143.1 CDS EcSMS35_1064 NC_010498.1 1076957 1077778 R identified by match to protein family HMM PF06067; hypothetical protein complement(1076957..1077778) Escherichia coli SMS-3-5 6144742 YP_001743144.1 CDS EcSMS35_1066 NC_010498.1 1077868 1078002 D identified by Glimmer3; putative; hypothetical protein 1077868..1078002 Escherichia coli SMS-3-5 6145295 YP_001743145.1 CDS EcSMS35_1065 NC_010498.1 1077999 1078409 R identified by Glimmer3; putative; hypothetical protein complement(1077999..1078409) Escherichia coli SMS-3-5 6144777 YP_001743146.1 CDS EcSMS35_1067 NC_010498.1 1078425 1079108 R identified by Glimmer3; putative; hypothetical protein complement(1078425..1079108) Escherichia coli SMS-3-5 6146770 YP_001743147.1 CDS EcSMS35_1068 NC_010498.1 1079244 1080314 R identified by match to protein family HMM PF01734; patatin family phospholipase complement(1079244..1080314) Escherichia coli SMS-3-5 6145294 YP_001743148.1 CDS EcSMS35_1069 NC_010498.1 1080311 1081216 R identified by similarity to GB:AAP18661.1; hypothetical protein complement(1080311..1081216) Escherichia coli SMS-3-5 6143369 YP_001743149.1 CDS EcSMS35_1070 NC_010498.1 1081213 1083609 R identified by similarity to GB:AAZ90778.1; hypothetical protein complement(1081213..1083609) Escherichia coli SMS-3-5 6143973 YP_001743150.1 CDS EcSMS35_1071 NC_010498.1 1083827 1084699 R identified by match to protein family HMM PF01926; putative GTPase complement(1083827..1084699) Escherichia coli SMS-3-5 6146878 YP_001743151.1 CDS EcSMS35_1072 NC_010498.1 1084783 1085934 R identified by Glimmer3; putative; hypothetical protein complement(1084783..1085934) Escherichia coli SMS-3-5 6147395 YP_001743152.1 CDS EcSMS35_1073 NC_010498.1 1087862 1088383 D IS150 transposase orfA 1087862..1088383 Escherichia coli SMS-3-5 6145510 YP_001743153.1 CDS EcSMS35_1074 NC_010498.1 1088380 1089231 D identified by match to protein family HMM PF00665; IS150 transposase orfB 1088380..1089231 Escherichia coli SMS-3-5 6146034 YP_001743154.1 CDS EcSMS35_1075 NC_010498.1 1089774 1090376 R hypothetical protein complement(1089774..1090376) Escherichia coli SMS-3-5 6144109 YP_001743155.1 CDS EcSMS35_1076 NC_010498.1 1090470 1090676 R identified by match to protein family HMM PF05930; prophage CP4-57 regulatory protein AlpA complement(1090470..1090676) Escherichia coli SMS-3-5 6143326 YP_001743156.1 CDS EcSMS35_1077 NC_010498.1 1092208 1092777 D hypothetical protein 1092208..1092777 Escherichia coli SMS-3-5 6147029 YP_001743157.1 CDS EcSMS35_1078 NC_010498.1 1093426 1093833 D hypothetical protein 1093426..1093833 Escherichia coli SMS-3-5 6143944 YP_001743158.1 CDS EcSMS35_1079 NC_010498.1 1094513 1095496 D identified by match to protein family HMM PF01610; ISL3 family transposase 1094513..1095496 Escherichia coli SMS-3-5 6143142 YP_001743159.1 CDS EcSMS35_1081 NC_010498.1 1096148 1097182 R identified by match to protein family HMM PF02126; phosphotriesterase family protein complement(1096148..1097182) Escherichia coli SMS-3-5 6144773 YP_001743160.1 CDS EcSMS35_1082 NC_010498.1 1097185 1098150 R identified by match to protein family HMM PF04657; hypothetical protein complement(1097185..1098150) Escherichia coli SMS-3-5 6145864 YP_001743161.1 CDS EcSMS35_1083 NC_010498.1 1098207 1098965 R identified by similarity to GB:CAD08081.1; match to protein family HMM PF07090; hypothetical protein complement(1098207..1098965) Escherichia coli SMS-3-5 6147007 YP_001743162.1 CDS EcSMS35_1084 NC_010498.1 1098979 1100193 R identified by match to protein family HMM PF00294; match to protein family HMM PF08220; match to protein family HMM PF08279; match to protein family HMM PF08543; PfkB family DNA-binding protein/kinase complement(1098979..1100193) Escherichia coli SMS-3-5 6146323 YP_001743163.1 CDS EcSMS35_1086 NC_010498.1 1101945 1102355 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1101945..1102355 Escherichia coli SMS-3-5 6146768 YP_001743164.1 CDS EcSMS35_1088 NC_010498.1 1102313 1103218 D identified by match to protein family HMM PF00665; IS2 transposase orfB 1102313..1103218 Escherichia coli SMS-3-5 6146240 YP_001743165.1 CDS EcSMS35_1087 NC_010498.1 1103143 1104309 R identified by match to protein family HMM PF00206; lyase complement(1103143..1104309) Escherichia coli SMS-3-5 6145966 YP_001743166.1 CDS EcSMS35_1089 NC_010498.1 1104532 1105830 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(1104532..1105830) Escherichia coli SMS-3-5 6146743 YP_001743167.1 CDS EcSMS35_1090 NC_010498.1 1105889 1106608 R identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035; aspartate racemase complement(1105889..1106608) Escherichia coli SMS-3-5 6142679 YP_001743168.1 CDS EcSMS35_1091 NC_010498.1 1106948 1107847 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1106948..1107847 Escherichia coli SMS-3-5 6143176 YP_001743169.1 CDS EcSMS35_1092 NC_010498.1 1108117 1108251 D identified by Glimmer3; putative; hypothetical protein 1108117..1108251 Escherichia coli SMS-3-5 6145935 YP_001743170.1 CDS EcSMS35_1094 NC_010498.1 1109201 1110493 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00881; match to protein family HMM TIGR00893; d-galactonate transporter complement(1109201..1110493) Escherichia coli SMS-3-5 6146749 YP_001743171.1 CDS EcSMS35_1095 NC_010498.1 1110613 1111761 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; galactonate dehydratase complement(1110613..1111761) Escherichia coli SMS-3-5 6144841 YP_001743172.1 CDS EcSMS35_1096 NC_010498.1 1111758 1112375 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(1111758..1112375) Escherichia coli SMS-3-5 6145175 YP_001743173.1 CDS dgoK_2 NC_010498.1 1112359 1113237 R identified by similarity to SP:P31459; match to protein family HMM PF05035; 2-dehydro-3-deoxygalactonokinase complement(1112359..1113237) Escherichia coli SMS-3-5 6145939 YP_001743174.1 CDS dgoR_2 NC_010498.1 1113234 1113923 R identified by similarity to SP:P31460; match to protein family HMM PF00392; match to protein family HMM PF07729; galactonate operon transcriptional repressor complement(1113234..1113923) Escherichia coli SMS-3-5 6146777 YP_001743175.1 CDS EcSMS35_1099 NC_010498.1 1114722 1114892 D identified by Glimmer3; putative; hypothetical protein 1114722..1114892 Escherichia coli SMS-3-5 6145057 YP_001743176.1 CDS EcSMS35_1100 NC_010498.1 1115155 1115466 D identified by match to protein family HMM PF01527; IS911 transposase orfA 1115155..1115466 Escherichia coli SMS-3-5 6146567 YP_001743177.1 CDS EcSMS35_1101 NC_010498.1 1115586 1116332 D identified by match to protein family HMM PF00665; IS911 transposase orfB 1115586..1116332 Escherichia coli SMS-3-5 6147278 YP_001743178.1 CDS EcSMS35_1102 NC_010498.1 1116552 1116686 D identified by Glimmer3; putative; hypothetical protein 1116552..1116686 Escherichia coli SMS-3-5 6144658 YP_001743179.1 CDS EcSMS35_1103 NC_010498.1 1117938 1119332 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 1117938..1119332 Escherichia coli SMS-3-5 6142867 YP_001743180.1 CDS EcSMS35_1104 NC_010498.1 1119437 1120468 D identified by match to protein family HMM PF00532; periplasmic sugar binding transcriptional regulator 1119437..1120468 Escherichia coli SMS-3-5 6147129 YP_001743181.1 CDS EcSMS35_1105 NC_010498.1 1120428 1121462 D identified by match to protein family HMM PF01156; inosine-uridine preferring nucleoside hydrolase 1120428..1121462 Escherichia coli SMS-3-5 6145080 YP_001743182.1 CDS EcSMS35_1106 NC_010498.1 1121526 1122239 D identified by match to protein family HMM PF02308; mgtC family protein 1121526..1122239 Escherichia coli SMS-3-5 6145766 YP_001743183.1 CDS EcSMS35_1110 NC_010498.1 1125254 1125532 D identified by similarity to GB:AAK03301.1; hypothetical protein 1125254..1125532 Escherichia coli SMS-3-5 6143965 YP_001743184.1 CDS EcSMS35_1111 NC_010498.1 1125870 1126901 R identified by match to protein family HMM PF01112; asparaginase family protein complement(1125870..1126901) Escherichia coli SMS-3-5 6146345 YP_001743185.1 CDS EcSMS35_1113 NC_010498.1 1128279 1128464 D hypothetical protein 1128279..1128464 Escherichia coli SMS-3-5 6146041 YP_001743186.1 CDS EcSMS35_1114 NC_010498.1 1128517 1129878 R identified by similarity to SP:P0ABP3; match to protein family HMM PF03606; match to protein family HMM PF06808; match to protein family HMM TIGR00771; anaerobic C4-dicarboxylate transporter complement(1128517..1129878) Escherichia coli SMS-3-5 6145118 YP_001743187.1 CDS EcSMS35_1115 NC_010498.1 1129875 1131131 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(1129875..1131131) Escherichia coli SMS-3-5 6143756 YP_001743188.1 CDS EcSMS35_1116 NC_010498.1 1131997 1133397 D identified by match to protein family HMM PF00206; putative aspartate ammonia-lyase 1131997..1133397 Escherichia coli SMS-3-5 6143285 YP_001743189.1 CDS EcSMS35_1117 NC_010498.1 1133553 1134887 D identified by similarity to SP:P0ABN5; match to protein family HMM PF03600; match to protein family HMM PF03605; match to protein family HMM TIGR00770; anaerobic C4-dicarboxylate transporter 1133553..1134887 Escherichia coli SMS-3-5 6142907 YP_001743190.1 CDS ansB NC_010498.1 1135375 1136421 D catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 1135375..1136421 Escherichia coli SMS-3-5 6146805 YP_001743191.1 CDS EcSMS35_1119 NC_010498.1 1137015 1137740 R identified by match to protein family HMM PF00072; response regulator complement(1137015..1137740) Escherichia coli SMS-3-5 6145098 YP_001743192.1 CDS EcSMS35_1120 NC_010498.1 1138719 1139375 R identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator complement(1138719..1139375) Escherichia coli SMS-3-5 6145822 YP_001743193.1 CDS EcSMS35_1121 NC_010498.1 1139530 1140846 D identified by match to protein family HMM PF03600; match to protein family HMM PF03605; match to protein family HMM TIGR00770; anaerobic C4-dicarboxylate transporter 1139530..1140846 Escherichia coli SMS-3-5 6143228 YP_001743194.1 CDS EcSMS35_1122 NC_010498.1 1140962 1142278 R identified by match to protein family HMM PF03600; match to protein family HMM PF03605; match to protein family HMM TIGR00770; anaerobic C4-dicarboxylate transporter complement(1140962..1142278) Escherichia coli SMS-3-5 6144736 YP_001743195.1 CDS EcSMS35_1123 NC_010498.1 1142343 1143719 R identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838; argininosuccinate lyase ArgH-like protein complement(1142343..1143719) Escherichia coli SMS-3-5 6146152 YP_001743196.1 CDS EcSMS35_1124 NC_010498.1 1144378 1144767 D identified by Glimmer3; putative; hypothetical protein 1144378..1144767 Escherichia coli SMS-3-5 6143249 YP_001743197.1 CDS EcSMS35_1125 NC_010498.1 1145153 1146385 D identified by similarity to GB:AAM53133.1; match to protein family HMM PF01507; immunoglobulin-binding regulator A-like protein 1145153..1146385 Escherichia coli SMS-3-5 6145428 YP_001743198.1 CDS EcSMS35_1127 NC_010498.1 1147269 1147385 R identified by Glimmer3; putative; hypothetical protein complement(1147269..1147385) Escherichia coli SMS-3-5 6145819 YP_001743199.1 CDS EcSMS35_1129 NC_010498.1 1150574 1150738 D hypothetical protein 1150574..1150738 Escherichia coli SMS-3-5 6142628 YP_001743200.1 CDS EcSMS35_1130 NC_010498.1 1150929 1151051 D hypothetical protein 1150929..1151051 Escherichia coli SMS-3-5 6144372 YP_001743201.1 CDS cobU NC_010498.1 1151203 1151748 D catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 1151203..1151748 Escherichia coli SMS-3-5 6146531 YP_001743202.1 CDS cobS NC_010498.1 1151745 1152488 D catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 1151745..1152488 Escherichia coli SMS-3-5 6143220 YP_001743203.1 CDS cobT NC_010498.1 1152500 1153579 D catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1152500..1153579 Escherichia coli SMS-3-5 6145478 YP_001743204.1 CDS EcSMS35_1134 NC_010498.1 1153644 1154576 D identified by match to protein family HMM PF03734; hypothetical protein 1153644..1154576 Escherichia coli SMS-3-5 6147052 YP_001743205.1 CDS nac NC_010498.1 1155034 1155951 D Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 1155034..1155951 Escherichia coli SMS-3-5 6143624 YP_001743206.1 CDS cbl NC_010498.1 1156053 1157003 D LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 1156053..1157003 Escherichia coli SMS-3-5 6145006 YP_001743207.1 CDS EcSMS35_1139 NC_010498.1 1157310 1158764 D identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; hypothetical protein 1157310..1158764 Escherichia coli SMS-3-5 6143626 YP_001743208.1 CDS EcSMS35_1141 NC_010498.1 1159179 1159301 D identified by Glimmer3; putative; hypothetical protein 1159179..1159301 Escherichia coli SMS-3-5 6143702 YP_001743209.1 CDS EcSMS35_1142 NC_010498.1 1159392 1160108 R yeeN; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein complement(1159392..1160108) Escherichia coli SMS-3-5 6143060 YP_001743210.1 CDS amn NC_010498.1 1160451 1161905 R Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase complement(1160451..1161905) Escherichia coli SMS-3-5 6143875 YP_001743211.1 CDS shiA NC_010498.1 1162007 1163323 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; shikimate transporter complement(1162007..1163323) Escherichia coli SMS-3-5 6144011 YP_001743212.1 CDS EcSMS35_1145 NC_010498.1 1163638 1164690 D hypothetical protein 1163638..1164690 Escherichia coli SMS-3-5 6144672 YP_001743213.1 CDS EcSMS35_1146 NC_010498.1 1164952 1172028 R yeeJ; identified by match to protein family HMM PF00801; match to protein family HMM PF02369; putative invasin complement(1164952..1172028) Escherichia coli SMS-3-5 6145381 YP_001743214.1 CDS EcSMS35_1148 NC_010498.1 1172518 1173315 R identified by match to protein family HMM PF06167; hypothetical protein complement(1172518..1173315) Escherichia coli SMS-3-5 6143691 YP_001743215.1 CDS EcSMS35_1150 NC_010498.1 1173551 1174576 R identified by match to protein family HMM PF00589; phage integrase family site specific recombinase complement(1173551..1174576) Escherichia coli SMS-3-5 6143687 YP_001743216.1 CDS EcSMS35_1151 NC_010498.1 1174576 1174779 R identified by similarity to GB:ABI42016.1; hypothetical protein complement(1174576..1174779) Escherichia coli SMS-3-5 6146637 YP_001743217.1 CDS EcSMS35_1152 NC_010498.1 1174838 1177279 R identified by match to protein family HMM PF00929; match to protein family HMM PF06630; exonuclease family protein complement(1174838..1177279) Escherichia coli SMS-3-5 6143440 YP_001743218.1 CDS EcSMS35_1153 NC_010498.1 1177373 1177564 R identified by match to protein family HMM PF07358; hypothetical protein complement(1177373..1177564) Escherichia coli SMS-3-5 6143376 YP_001743219.1 CDS dicB NC_010498.1 1177561 1177749 R identified by match to protein family HMM PF05358; division inhibition protein DicB complement(1177561..1177749) Escherichia coli SMS-3-5 6143384 YP_001743220.1 CDS EcSMS35_1155 NC_010498.1 1177766 1177888 D identified by Glimmer3; putative; hypothetical protein 1177766..1177888 Escherichia coli SMS-3-5 6144568 YP_001743221.1 CDS EcSMS35_1156 NC_010498.1 1178317 1178535 R identified by Glimmer3; putative; hypothetical protein complement(1178317..1178535) Escherichia coli SMS-3-5 6143916 YP_001743222.1 CDS EcSMS35_1157 NC_010498.1 1178565 1178693 R ydfB; identified by Glimmer3; putative; hypothetical protein complement(1178565..1178693) Escherichia coli SMS-3-5 6146021 YP_001743223.1 CDS EcSMS35_1158 NC_010498.1 1178695 1178850 R identified by match to protein family HMM PF07151; hypothetical protein complement(1178695..1178850) Escherichia coli SMS-3-5 6146025 YP_001743224.1 CDS EcSMS35_1159 NC_010498.1 1179525 1179752 D DNA-binding transcriptional regulator DicC 1179525..1179752 Escherichia coli SMS-3-5 6145472 YP_001743225.1 CDS EcSMS35_1160 NC_010498.1 1179736 1180287 D identified by match to protein family HMM PF06254; hypothetical protein 1179736..1180287 Escherichia coli SMS-3-5 6146739 YP_001743226.1 CDS EcSMS35_1161 NC_010498.1 1180259 1181299 D hypothetical protein 1180259..1181299 Escherichia coli SMS-3-5 6146216 YP_001743227.1 CDS EcSMS35_1162 NC_010498.1 1181331 1181753 D hypothetical protein 1181331..1181753 Escherichia coli SMS-3-5 6145274 YP_001743228.1 CDS EcSMS35_1163 NC_010498.1 1181787 1182557 D identified by match to protein family HMM PF07789; hypothetical protein 1181787..1182557 Escherichia coli SMS-3-5 6145037 YP_001743229.1 CDS EcSMS35_1164 NC_010498.1 1182573 1182965 D identified by similarity to GB:CAD05604.1; match to protein family HMM PF06163; hypothetical protein 1182573..1182965 Escherichia coli SMS-3-5 6143344 YP_001743230.1 CDS EcSMS35_1165 NC_010498.1 1182962 1183258 D identified by similarity to GB:ABE56533.1; hypothetical protein 1182962..1183258 Escherichia coli SMS-3-5 6144277 YP_001743231.1 CDS EcSMS35_1166 NC_010498.1 1183255 1183716 D identified by similarity to GB:AAK28855.1; hypothetical protein 1183255..1183716 Escherichia coli SMS-3-5 6147521 YP_001743232.1 CDS EcSMS35_1167 NC_010498.1 1183694 1184050 D identified by similarity to GB:ABF03554.1; hypothetical protein 1183694..1184050 Escherichia coli SMS-3-5 6142818 YP_001743233.1 CDS EcSMS35_1168 NC_010498.1 1184144 1184326 D identified by Glimmer3; putative; hypothetical protein 1184144..1184326 Escherichia coli SMS-3-5 6146165 YP_001743234.1 CDS EcSMS35_1169 NC_010498.1 1184319 1184495 D identified by similarity to GB:BAB93828.1; hypothetical protein 1184319..1184495 Escherichia coli SMS-3-5 6147016 YP_001743235.1 CDS EcSMS35_1170 NC_010498.1 1184492 1185007 D identified by similarity to GB:ABF04172.1; hypothetical protein 1184492..1185007 Escherichia coli SMS-3-5 6145483 YP_001743236.1 CDS EcSMS35_1171 NC_010498.1 1185211 1185339 D identified by Glimmer3; putative; hypothetical protein 1185211..1185339 Escherichia coli SMS-3-5 6145619 YP_001743237.1 CDS EcSMS35_1172 NC_010498.1 1185927 1186187 D hypothetical protein 1185927..1186187 Escherichia coli SMS-3-5 6144087 YP_001743238.1 CDS EcSMS35_1173 NC_010498.1 1186201 1186332 R identified by Glimmer3; putative; hypothetical protein complement(1186201..1186332) Escherichia coli SMS-3-5 6145222 YP_001743239.1 CDS EcSMS35_1174 NC_010498.1 1186534 1187589 D identified by match to protein family HMM PF06914; hypothetical protein 1186534..1187589 Escherichia coli SMS-3-5 6143132 YP_001743240.1 CDS EcSMS35_1175 NC_010498.1 1187590 1187955 D identified by match to protein family HMM PF05866; crossover junction endodeoxyribonuclease RusA-like protein 1187590..1187955 Escherichia coli SMS-3-5 6144870 YP_001743241.1 CDS EcSMS35_1176 NC_010498.1 1187952 1188641 D identified by similarity to SP:P13870; match to protein family HMM PF06323; antitermination protein Q 1187952..1188641 Escherichia coli SMS-3-5 6147032 YP_001743242.1 CDS EcSMS35_1181 NC_010498.1 1189437 1189652 D identified by match to protein family HMM PF04971; lambda phage S protein family protein 1189437..1189652 Escherichia coli SMS-3-5 6143633 YP_001743243.1 CDS EcSMS35_1182 NC_010498.1 1189657 1190007 D ydfR; identified by match to protein family HMM PF07041; hypothetical protein 1189657..1190007 Escherichia coli SMS-3-5 6146292 YP_001743244.1 CDS EcSMS35_1183 NC_010498.1 1190071 1190604 D identified by match to protein family HMM PF00959; phage lysozyme 1190071..1190604 Escherichia coli SMS-3-5 6146971 YP_001743245.1 CDS EcSMS35_1184 NC_010498.1 1190601 1191068 D identified by match to protein family HMM PF03245; bacteriophage lysis protein 1190601..1191068 Escherichia coli SMS-3-5 6145493 YP_001743246.1 CDS EcSMS35_1185 NC_010498.1 1191610 1192092 D identified by match to protein family HMM PF05119; match to protein family HMM TIGR01558; P27 family phage terminase small subunit 1191610..1192092 Escherichia coli SMS-3-5 6145878 YP_001743247.1 CDS EcSMS35_1186 NC_010498.1 1192092 1193849 D identified by match to protein family HMM PF03354; putative phage terminase, large subunit 1192092..1193849 Escherichia coli SMS-3-5 6146211 YP_001743248.1 CDS EcSMS35_1187 NC_010498.1 1193861 1194043 D identified by similarity to GB:AAZ89395.1; hypothetical protein 1193861..1194043 Escherichia coli SMS-3-5 6143575 YP_001743249.1 CDS EcSMS35_1188 NC_010498.1 1194043 1195284 D identified by match to protein family HMM PF04860; match to protein family HMM TIGR01537; HK97 family phage portal protein 1194043..1195284 Escherichia coli SMS-3-5 6144955 YP_001743250.1 CDS EcSMS35_1189 NC_010498.1 1195262 1195912 D identified by match to protein family HMM PF04586; match to protein family HMM TIGR01543; HK97 family phage prohead protease 1195262..1195912 Escherichia coli SMS-3-5 6146912 YP_001743251.1 CDS EcSMS35_1190 NC_010498.1 1195927 1197132 D identified by match to protein family HMM PF05065; match to protein family HMM TIGR01554; HK97 family phage major capsid protein 1195927..1197132 Escherichia coli SMS-3-5 6143991 YP_001743252.1 CDS EcSMS35_1191 NC_010498.1 1197184 1197372 D identified by similarity to GB:ABF02516.1; hypothetical protein 1197184..1197372 Escherichia coli SMS-3-5 6145330 YP_001743253.1 CDS EcSMS35_1192 NC_010498.1 1197384 1197689 D identified by similarity to GB:AAL89415.1; hypothetical protein 1197384..1197689 Escherichia coli SMS-3-5 6144767 YP_001743254.1 CDS EcSMS35_1193 NC_010498.1 1198036 1198482 D identified by match to protein family HMM PF07772; match to protein family HMM TIGR01725; HK97 family phage protein 1198036..1198482 Escherichia coli SMS-3-5 6144318 YP_001743255.1 CDS EcSMS35_1194 NC_010498.1 1198479 1198823 D identified by similarity to GB:ABP60903.1; hypothetical protein 1198479..1198823 Escherichia coli SMS-3-5 6143004 YP_001743256.1 CDS EcSMS35_1195 NC_010498.1 1198883 1199587 D identified by similarity to GB:AAF31091.1; hypothetical protein 1198883..1199587 Escherichia coli SMS-3-5 6147419 YP_001743257.1 CDS EcSMS35_1196 NC_010498.1 1199602 1199973 D identified by match to protein family HMM PF06222; phage tail assembly chaperone 1199602..1199973 Escherichia coli SMS-3-5 6146945 YP_001743258.1 CDS EcSMS35_1197 NC_010498.1 1199985 1200275 D identified by similarity to GB:AAL40287.1; hypothetical protein 1199985..1200275 Escherichia coli SMS-3-5 6144901 YP_001743259.1 CDS EcSMS35_1198 NC_010498.1 1200321 1203548 D identified by match to protein family HMM TIGR01541; match to protein family HMM TIGR02675; lambda family phage tail tape measure protein 1200321..1203548 Escherichia coli SMS-3-5 6146619 YP_001743260.1 CDS EcSMS35_1199 NC_010498.1 1203541 1203882 D identified by match to protein family HMM PF05939; phage minor tail protein 1203541..1203882 Escherichia coli SMS-3-5 6143387 YP_001743261.1 CDS EcSMS35_1200 NC_010498.1 1203882 1204580 D identified by match to protein family HMM PF05100; match to protein family HMM TIGR01600; phage minor tail protein L 1203882..1204580 Escherichia coli SMS-3-5 6145220 YP_001743262.1 CDS EcSMS35_1201 NC_010498.1 1204585 1205328 D identified by match to protein family HMM PF00877; tail assembly protein 1204585..1205328 Escherichia coli SMS-3-5 6147022 YP_001743263.1 CDS EcSMS35_1202 NC_010498.1 1205226 1205873 D identified by match to protein family HMM PF06805; bacteriophage lambda tail assembly protein I 1205226..1205873 Escherichia coli SMS-3-5 6143925 YP_001743264.1 CDS EcSMS35_1203 NC_010498.1 1205934 1209413 D identified by match to protein family HMM PF00041; match to protein family HMM PF09327; fibronectin type III domain-containing protein 1205934..1209413 Escherichia coli SMS-3-5 6145591 YP_001743265.1 CDS EcSMS35_1204 NC_010498.1 1209481 1210080 D identified by match to protein family HMM PF06316; Ail/Lom family protein 1209481..1210080 Escherichia coli SMS-3-5 6147372 YP_001743266.1 CDS EcSMS35_1206 NC_010498.1 1210145 1212682 D identified by match to protein family HMM PF08400; putative prophage side tail fiber protein 1210145..1212682 Escherichia coli SMS-3-5 6142895 YP_001743267.1 CDS EcSMS35_1205 NC_010498.1 1212522 1213427 R identified by similarity to SP:P51026; IS2 transposase orfB complement(1212522..1213427) Escherichia coli SMS-3-5 6144045 YP_001743268.1 CDS EcSMS35_1207 NC_010498.1 1213385 1213795 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(1213385..1213795) Escherichia coli SMS-3-5 6143594 YP_001743269.1 CDS EcSMS35_1208 NC_010498.1 1213859 1214140 D identified by similarity to GB:BAB97540.1; hypothetical protein 1213859..1214140 Escherichia coli SMS-3-5 6146908 YP_001743270.1 CDS EcSMS35_1209 NC_010498.1 1214150 1215190 D identified by Glimmer3; putative; hypothetical protein 1214150..1215190 Escherichia coli SMS-3-5 6147283 YP_001743271.1 CDS EcSMS35_1210 NC_010498.1 1215227 1215520 D identified by Glimmer3; putative; hypothetical protein 1215227..1215520 Escherichia coli SMS-3-5 6146239 YP_001743272.1 CDS EcSMS35_1211 NC_010498.1 1216501 1217031 R identified by match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit complement(1216501..1217031) Escherichia coli SMS-3-5 6143371 YP_001743273.1 CDS EcSMS35_1212 NC_010498.1 1217374 1218024 R identified by match to protein family HMM PF09223; hypothetical protein complement(1217374..1218024) Escherichia coli SMS-3-5 6142982 YP_001743274.1 CDS EcSMS35_1213 NC_010498.1 1218281 1218916 R in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ complement(1218281..1218916) Escherichia coli SMS-3-5 6144493 YP_001743275.1 CDS EcSMS35_1214 NC_010498.1 1218917 1219921 R in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY complement(1218917..1219921) Escherichia coli SMS-3-5 6145897 YP_001743276.1 CDS EcSMS35_1215 NC_010498.1 1220030 1220443 R identified by match to protein family HMM PF00576; match to protein family HMM TIGR02962; transthyretin family protein complement(1220030..1220443) Escherichia coli SMS-3-5 6145347 YP_001743277.1 CDS EcSMS35_1216 NC_010498.1 1220465 1221247 D induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 1220465..1221247 Escherichia coli SMS-3-5 6144508 YP_001743278.1 CDS EcSMS35_1217 NC_010498.1 1221247 1222605 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM TIGR01386; heavy metal sensor histidine kinase 1221247..1222605 Escherichia coli SMS-3-5 6144957 YP_001743279.1 CDS hchA NC_010498.1 1222712 1223563 R Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA complement(1222712..1223563) Escherichia coli SMS-3-5 6145412 YP_001743280.1 CDS EcSMS35_1219 NC_010498.1 1223584 1223727 R identified by Glimmer3; putative; hypothetical protein complement(1223584..1223727) Escherichia coli SMS-3-5 6143550 YP_001743281.1 CDS EcSMS35_1220 NC_010498.1 1223987 1224154 D identified by Glimmer3; putative; hypothetical protein 1223987..1224154 Escherichia coli SMS-3-5 6146425 YP_001743282.1 CDS EcSMS35_1221 NC_010498.1 1224155 1225318 R identified by similarity to SP:P77747; match to protein family HMM PF00267; porin family protein complement(1224155..1225318) Escherichia coli SMS-3-5 6143519 YP_001743283.1 CDS EcSMS35_1222 NC_010498.1 1225949 1226251 D hypothetical protein 1225949..1226251 Escherichia coli SMS-3-5 6146557 YP_001743284.1 CDS EcSMS35_1223 NC_010498.1 1226291 1226986 D identified by match to protein family HMM PF01966; hypothetical protein 1226291..1226986 Escherichia coli SMS-3-5 6144560 YP_001743285.1 CDS dcm NC_010498.1 1227053 1228471 D identified by similarity to SP:P0AED9; match to protein family HMM PF00145; match to protein family HMM TIGR00675; DNA cytosine methylase 1227053..1228471 Escherichia coli SMS-3-5 6147496 YP_001743286.1 CDS vsr NC_010498.1 1228452 1228922 D identified by match to protein family HMM PF03852; match to protein family HMM TIGR00632; very short patch repair protein 1228452..1228922 Escherichia coli SMS-3-5 6145587 YP_001743287.1 CDS EcSMS35_1225 NC_010498.1 1228911 1229831 R identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; hypothetical protein complement(1228911..1229831) Escherichia coli SMS-3-5 6142845 YP_001743288.1 CDS EcSMS35_1227 NC_010498.1 1230010 1230921 D identified by match to protein family HMM PF05661; hypothetical protein 1230010..1230921 Escherichia coli SMS-3-5 6145894 YP_001743289.1 CDS EcSMS35_1228 NC_010498.1 1231000 1231182 D hypothetical protein 1231000..1231182 Escherichia coli SMS-3-5 6144856 YP_001743290.1 CDS EcSMS35_1230 NC_010498.1 1231371 1233047 D yedQ; identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1231371..1233047 Escherichia coli SMS-3-5 6146690 YP_001743291.1 CDS EcSMS35_1229 NC_010498.1 1233044 1233859 R catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase complement(1233044..1233859) Escherichia coli SMS-3-5 6145054 YP_001743292.1 CDS EcSMS35_1231 NC_010498.1 1234156 1234383 R hypothetical protein complement(1234156..1234383) Escherichia coli SMS-3-5 6143527 YP_001743293.1 CDS EcSMS35_1232 NC_010498.1 1234546 1234734 D hypothetical protein 1234546..1234734 Escherichia coli SMS-3-5 6146788 YP_001743294.1 CDS rcsA NC_010498.1 1234778 1235401 R identified by match to protein family HMM PF00196; colanic acid capsular biosynthesis activation protein A complement(1234778..1235401) Escherichia coli SMS-3-5 6145138 YP_001743295.1 CDS fliR NC_010498.1 1235691 1236476 R FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR complement(1235691..1236476) Escherichia coli SMS-3-5 6146807 YP_001743296.1 CDS fliQ NC_010498.1 1236485 1236754 R with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ complement(1236485..1236754) Escherichia coli SMS-3-5 6143732 YP_001743297.1 CDS fliP NC_010498.1 1236764 1237501 R FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP complement(1236764..1237501) Escherichia coli SMS-3-5 6145718 YP_001743298.1 CDS fliO NC_010498.1 1237501 1237866 R with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO complement(1237501..1237866) Escherichia coli SMS-3-5 6146629 YP_001743299.1 CDS fliN NC_010498.1 1237869 1238282 R One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN complement(1237869..1238282) Escherichia coli SMS-3-5 6147142 YP_001743300.1 CDS fliM NC_010498.1 1238279 1239283 R with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM complement(1238279..1239283) Escherichia coli SMS-3-5 6143030 YP_001743301.1 CDS fliL NC_010498.1 1239288 1239752 R interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL complement(1239288..1239752) Escherichia coli SMS-3-5 6143513 YP_001743302.1 CDS fliK NC_010498.1 1239857 1240984 R identified by match to protein family HMM PF02120; flagellar hook-length control protein complement(1239857..1240984) Escherichia coli SMS-3-5 6146390 YP_001743303.1 CDS fliJ NC_010498.1 1240981 1241424 R rod/hook and filament chaperone; flagellar biosynthesis chaperone complement(1240981..1241424) Escherichia coli SMS-3-5 6146340 YP_001743304.1 CDS fliI NC_010498.1 1241443 1242816 R involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase complement(1241443..1242816) Escherichia coli SMS-3-5 6145033 YP_001743305.1 CDS fliH NC_010498.1 1242816 1243502 R binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H complement(1242816..1243502) Escherichia coli SMS-3-5 6146896 YP_001743306.1 CDS fliG NC_010498.1 1243495 1244490 R One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G complement(1243495..1244490) Escherichia coli SMS-3-5 6143835 YP_001743307.1 CDS fliF NC_010498.1 1244483 1246141 R the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein complement(1244483..1246141) Escherichia coli SMS-3-5 6145664 YP_001743308.1 CDS fliE NC_010498.1 1246356 1246670 D forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 1246356..1246670 Escherichia coli SMS-3-5 6146631 YP_001743309.1 CDS EcSMS35_1248 NC_010498.1 1247021 1248160 D identified by Glimmer3; putative; hypothetical protein 1247021..1248160 Escherichia coli SMS-3-5 6146726 YP_001743310.1 CDS EcSMS35_1249 NC_010498.1 1248298 1248777 R identified by match to protein family HMM PF00583; acetyltransferase complement(1248298..1248777) Escherichia coli SMS-3-5 6143452 YP_001743311.1 CDS EcSMS35_1250 NC_010498.1 1248888 1249556 R yedK; identified by match to protein family HMM PF02586; hypothetical protein complement(1248888..1249556) Escherichia coli SMS-3-5 6146622 YP_001743312.1 CDS EcSMS35_1251 NC_010498.1 1249665 1249898 R identified by match to protein family HMM PF01206; hypothetical protein complement(1249665..1249898) Escherichia coli SMS-3-5 6143961 YP_001743313.1 CDS EcSMS35_1252 NC_010498.1 1249895 1251100 R identified by match to protein family HMM PF04143; putative inner membrane protein complement(1249895..1251100) Escherichia coli SMS-3-5 6144581 YP_001743314.1 CDS EcSMS35_1253 NC_010498.1 1251287 1251700 D hypothetical protein 1251287..1251700 Escherichia coli SMS-3-5 6147506 YP_001743315.1 CDS amyA NC_010498.1 1251734 1253221 R converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase complement(1251734..1253221) Escherichia coli SMS-3-5 6142793 YP_001743316.1 CDS fliT NC_010498.1 1253299 1253664 R binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT complement(1253299..1253664) Escherichia coli SMS-3-5 6143771 YP_001743317.1 CDS fliS NC_010498.1 1253664 1254074 R flagellin specific chaperone; flagellar protein FliS complement(1253664..1254074) Escherichia coli SMS-3-5 6147442 YP_001743318.1 CDS fliD NC_010498.1 1254099 1255505 R involved in flagellin assembly; flagellar capping protein complement(1254099..1255505) Escherichia coli SMS-3-5 6145013 YP_001743319.1 CDS fliC NC_010498.1 1255771 1257408 D structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 1255771..1257408 Escherichia coli SMS-3-5 6144795 YP_001743320.1 CDS EcSMS35_1259 NC_010498.1 1257535 1257654 R identified by Glimmer3; putative; hypothetical protein complement(1257535..1257654) Escherichia coli SMS-3-5 6146688 YP_001743321.1 CDS fliA NC_010498.1 1257728 1258447 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 1257728..1258447 Escherichia coli SMS-3-5 6145837 YP_001743322.1 CDS EcSMS35_1261 NC_010498.1 1258493 1259044 D expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 1258493..1259044 Escherichia coli SMS-3-5 6143303 YP_001743323.1 CDS fliY NC_010498.1 1259132 1259932 D identified by match to protein family HMM PF00497; cystine transporter subunit 1259132..1259932 Escherichia coli SMS-3-5 6146883 YP_001743324.1 CDS dcyD NC_010498.1 1260037 1261023 D catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1260037..1261023 Escherichia coli SMS-3-5 6144001 YP_001743325.1 CDS EcSMS35_1264 NC_010498.1 1261038 1261706 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; L-cystine ABC transporter permease 1261038..1261706 Escherichia coli SMS-3-5 6143032 YP_001743326.1 CDS yecC NC_010498.1 1261703 1262455 D identified by match to protein family HMM PF00005; putative amino-acid ABC transporter ATP-binding protein YecC 1261703..1262455 Escherichia coli SMS-3-5 6145551 YP_001743327.1 CDS sdiA NC_010498.1 1262685 1263407 D regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 1262685..1263407 Escherichia coli SMS-3-5 6145924 YP_001743328.1 CDS EcSMS35_1267 NC_010498.1 1263474 1263698 R hypothetical protein complement(1263474..1263698) Escherichia coli SMS-3-5 6142726 YP_001743329.1 CDS EcSMS35_1268 NC_010498.1 1263790 1263918 D hypothetical protein 1263790..1263918 Escherichia coli SMS-3-5 6147276 YP_001743330.1 CDS uvrY NC_010498.1 1264157 1264813 D in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1264157..1264813 Escherichia coli SMS-3-5 6143532 YP_001743331.1 CDS uvrC NC_010498.1 1264810 1266642 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1264810..1266642 Escherichia coli SMS-3-5 6142852 YP_001743332.1 CDS pgsA NC_010498.1 1266699 1267247 D identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; phosphatidylglycerophosphate synthetase 1266699..1267247 Escherichia coli SMS-3-5 6144973 YP_001743333.1 CDS EcSMS35_1275 NC_010498.1 1267897 1268562 D identified by match to protein family HMM PF02810; match to protein family HMM TIGR02292; hypothetical protein 1267897..1268562 Escherichia coli SMS-3-5 6143661 YP_001743334.1 CDS tyrP NC_010498.1 1268624 1269835 R identified by match to protein family HMM PF01490; match to protein family HMM PF03222; match to protein family HMM TIGR00837; tyrosine-specific transport protein complement(1268624..1269835) Escherichia coli SMS-3-5 6146871 YP_001743335.1 CDS EcSMS35_1277 NC_010498.1 1270026 1270265 D hypothetical protein 1270026..1270265 Escherichia coli SMS-3-5 6146562 YP_001743336.1 CDS ftnA NC_010498.1 1270303 1270800 R cytoplasmic iron storage protein; ferritin complement(1270303..1270800) Escherichia coli SMS-3-5 6143332 YP_001743337.1 CDS EcSMS35_1279 NC_010498.1 1270825 1270962 D identified by Glimmer3; putative; hypothetical protein 1270825..1270962 Escherichia coli SMS-3-5 6147120 YP_001743338.1 CDS EcSMS35_1280 NC_010498.1 1270972 1271226 R putative lipoprotein complement(1270972..1271226) Escherichia coli SMS-3-5 6145072 YP_001743339.1 CDS EcSMS35_1281 NC_010498.1 1271501 1271647 R identified by Glimmer3; putative; hypothetical protein complement(1271501..1271647) Escherichia coli SMS-3-5 6145745 YP_001743340.1 CDS EcSMS35_1282 NC_010498.1 1271759 1272010 D identified by similarity to GB:ABB65745.1; hypothetical protein 1271759..1272010 Escherichia coli SMS-3-5 6144287 YP_001743341.1 CDS EcSMS35_1283 NC_010498.1 1272089 1272592 R identified by match to protein family HMM PF00210; ferritin family protein complement(1272089..1272592) Escherichia coli SMS-3-5 6144358 YP_001743342.1 CDS EcSMS35_1284 NC_010498.1 1272741 1272890 D identified by Glimmer3; putative; hypothetical protein 1272741..1272890 Escherichia coli SMS-3-5 6147068 YP_001743343.1 CDS araF NC_010498.1 1273388 1274377 D identified by match to protein family HMM PF00532; L-arabinose ABC transporter periplasmic L-arabinose-binding protein 1273388..1274377 Escherichia coli SMS-3-5 6142831 YP_001743344.1 CDS araG NC_010498.1 1274447 1275961 D Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 1274447..1275961 Escherichia coli SMS-3-5 6145114 YP_001743345.1 CDS araH NC_010498.1 1275976 1276962 D Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1275976..1276962 Escherichia coli SMS-3-5 6146473 YP_001743346.1 CDS otsB NC_010498.1 1277129 1277929 D biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1277129..1277929 Escherichia coli SMS-3-5 6144436 YP_001743347.1 CDS otsA NC_010498.1 1277904 1279328 D identified by match to protein family HMM PF00982; match to protein family HMM TIGR02400; trehalose-6-phosphate synthase 1277904..1279328 Escherichia coli SMS-3-5 6143857 YP_001743348.1 CDS uspC NC_010498.1 1279335 1279763 R ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC complement(1279335..1279763) Escherichia coli SMS-3-5 6143040 YP_001743349.1 CDS EcSMS35_1291 NC_010498.1 1280427 1280543 D identified by Glimmer3; putative; hypothetical protein 1280427..1280543 Escherichia coli SMS-3-5 6143597 YP_001743350.1 CDS flhD NC_010498.1 1280543 1280893 D with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 1280543..1280893 Escherichia coli SMS-3-5 6146925 YP_001743351.1 CDS flhC NC_010498.1 1280896 1281474 D With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 1280896..1281474 Escherichia coli SMS-3-5 6146226 YP_001743352.1 CDS motA NC_010498.1 1281601 1282488 D With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1281601..1282488 Escherichia coli SMS-3-5 6145901 YP_001743353.1 CDS motB NC_010498.1 1282485 1283411 D with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1282485..1283411 Escherichia coli SMS-3-5 6145233 YP_001743354.1 CDS cheA NC_010498.1 1283422 1285380 D chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1283422..1285380 Escherichia coli SMS-3-5 6143455 YP_001743355.1 CDS cheW NC_010498.1 1285401 1285904 D identified by match to protein family HMM PF01584; purine-binding chemotaxis protein 1285401..1285904 Escherichia coli SMS-3-5 6142766 YP_001743356.1 CDS tar NC_010498.1 1286049 1287710 D identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein II 1286049..1287710 Escherichia coli SMS-3-5 6146189 YP_001743357.1 CDS tap NC_010498.1 1287756 1289357 D mediates taxis toward dipeptides; methyl-accepting protein IV 1287756..1289357 Escherichia coli SMS-3-5 6144587 YP_001743358.1 CDS cheR NC_010498.1 1289376 1290236 D methylates the MCP; chemotaxis methyltransferase CheR 1289376..1290236 Escherichia coli SMS-3-5 6143934 YP_001743359.1 CDS cheB NC_010498.1 1290239 1291288 D regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1290239..1291288 Escherichia coli SMS-3-5 6142801 YP_001743360.1 CDS cheY NC_010498.1 1291303 1291692 D chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1291303..1291692 Escherichia coli SMS-3-5 6147259 YP_001743361.1 CDS cheZ NC_010498.1 1291703 1292347 D cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1291703..1292347 Escherichia coli SMS-3-5 6146716 YP_001743362.1 CDS EcSMS35_1304 NC_010498.1 1292435 1293187 R identified by similarity to GB:ABA77767.1; hypothetical protein complement(1292435..1293187) Escherichia coli SMS-3-5 6144988 YP_001743363.1 CDS EcSMS35_1305 NC_010498.1 1293156 1294664 R putative deoxyguanosinetriphosphate triphosphohydrolase complement(1293156..1294664) Escherichia coli SMS-3-5 6145524 YP_001743364.1 CDS EcSMS35_1306 NC_010498.1 1294746 1294868 R identified by Glimmer3; putative; hypothetical protein complement(1294746..1294868) Escherichia coli SMS-3-5 6143408 YP_001743365.1 CDS flhB NC_010498.1 1294901 1296049 D membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1294901..1296049 Escherichia coli SMS-3-5 6144489 YP_001743366.1 CDS flhA NC_010498.1 1296042 1298120 D membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 1296042..1298120 Escherichia coli SMS-3-5 6147295 YP_001743367.1 CDS flhE NC_010498.1 1298120 1298512 D identified by match to protein family HMM PF06366; flagellar protein FlhE 1298120..1298512 Escherichia coli SMS-3-5 6146435 YP_001743368.1 CDS argS NC_010498.1 1298565 1300298 R catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase complement(1298565..1300298) Escherichia coli SMS-3-5 6147131 YP_001743369.1 CDS EcSMS35_1311 NC_010498.1 1300508 1301080 D identified by match to protein family HMM PF06185; hypothetical protein 1300508..1301080 Escherichia coli SMS-3-5 6147510 YP_001743370.1 CDS cutC NC_010498.1 1301094 1301840 D identified by match to protein family HMM PF03932; copper homeostasis protein CutC 1301094..1301840 Escherichia coli SMS-3-5 6144879 YP_001743371.1 CDS torY NC_010498.1 1302228 1303328 D identified by match to protein family HMM PF03264; trimethylamine N-oxide reductase III, c-type cytochrome subunit TorY 1302228..1303328 Escherichia coli SMS-3-5 6145393 YP_001743372.1 CDS torZ NC_010498.1 1303353 1305782 D identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; match to protein family HMM TIGR01409; trimethylamine N-oxide reductase III, subunit TorZ 1303353..1305782 Escherichia coli SMS-3-5 6146201 YP_001743373.1 CDS EcSMS35_1315 NC_010498.1 1305817 1306788 R identified by match to protein family HMM PF08003; match to protein family HMM PF08241; match to protein family HMM TIGR00452; putative methyltransferase complement(1305817..1306788) Escherichia coli SMS-3-5 6146734 YP_001743374.1 CDS EcSMS35_1316 NC_010498.1 1306785 1307528 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00740; putative methyltransferase complement(1306785..1307528) Escherichia coli SMS-3-5 6147391 YP_001743375.1 CDS EcSMS35_1317 NC_010498.1 1307569 1307964 R putative inner membrane protein complement(1307569..1307964) Escherichia coli SMS-3-5 6143469 YP_001743376.1 CDS EcSMS35_1318 NC_010498.1 1308017 1308835 R identified by match to protein family HMM PF01904; hypothetical protein complement(1308017..1308835) Escherichia coli SMS-3-5 6144243 YP_001743377.1 CDS EcSMS35_1319 NC_010498.1 1308832 1309398 R identified by match to protein family HMM PF00857; hypothetical protein complement(1308832..1309398) Escherichia coli SMS-3-5 6145231 YP_001743378.1 CDS aspS NC_010498.1 1309708 1311480 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1309708..1311480 Escherichia coli SMS-3-5 6145898 YP_001743379.1 CDS ntpA NC_010498.1 1311482 1311925 D converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1311482..1311925 Escherichia coli SMS-3-5 6146410 YP_001743380.1 CDS EcSMS35_1322 NC_010498.1 1311954 1312694 D yebC; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 1311954..1312694 Escherichia coli SMS-3-5 6146759 YP_001743381.1 CDS ruvC NC_010498.1 1312729 1313250 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1312729..1313250 Escherichia coli SMS-3-5 6147456 YP_001743382.1 CDS EcSMS35_1324 NC_010498.1 1313252 1313854 R identified by match to protein family HMM PF06520; hypothetical protein complement(1313252..1313854) Escherichia coli SMS-3-5 6146571 YP_001743383.1 CDS ruvA NC_010498.1 1314129 1314740 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1314129..1314740 Escherichia coli SMS-3-5 6144849 YP_001743384.1 CDS ruvB NC_010498.1 1314749 1315759 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1314749..1315759 Escherichia coli SMS-3-5 6142848 YP_001743385.1 CDS znuB NC_010498.1 1315906 1316691 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component complement(1315906..1316691) Escherichia coli SMS-3-5 6145703 YP_001743386.1 CDS znuC NC_010498.1 1316688 1317443 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase complement(1316688..1317443) Escherichia coli SMS-3-5 6143998 YP_001743387.1 CDS znuA NC_010498.1 1317396 1318454 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 1317396..1318454 Escherichia coli SMS-3-5 6146875 YP_001743388.1 CDS EcSMS35_1330 NC_010498.1 1318470 1319792 D identified by match to protein family HMM PF01476; match to protein family HMM PF01551; match to protein family HMM PF04225; match to protein family HMM PF08525; hypothetical protein 1318470..1319792 Escherichia coli SMS-3-5 6145926 YP_001743389.1 CDS msbB NC_010498.1 1319911 1320882 D Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1319911..1320882 Escherichia coli SMS-3-5 6146686 YP_001743390.1 CDS pykA NC_010498.1 1321014 1322456 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(1321014..1322456) Escherichia coli SMS-3-5 6144758 YP_001743391.1 CDS EcSMS35_1333 NC_010498.1 1322584 1323453 R Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR complement(1322584..1323453) Escherichia coli SMS-3-5 6144999 YP_001743392.1 CDS EcSMS35_1334 NC_010498.1 1323476 1323625 D hypothetical protein 1323476..1323625 Escherichia coli SMS-3-5 6143059 YP_001743393.1 CDS zwf NC_010498.1 1323791 1325266 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1323791..1325266 Escherichia coli SMS-3-5 6143997 YP_001743394.1 CDS edd NC_010498.1 1325501 1327312 D catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1325501..1327312 Escherichia coli SMS-3-5 6142790 YP_001743395.1 CDS eda NC_010498.1 1327349 1327990 D catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1327349..1327990 Escherichia coli SMS-3-5 6143342 YP_001743396.1 CDS purT NC_010498.1 1328046 1329224 R non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 complement(1328046..1329224) Escherichia coli SMS-3-5 6146771 YP_001743397.1 CDS EcSMS35_1339 NC_010498.1 1329358 1329648 D identified by match to protein family HMM PF07130; DNA damage-inducible protein YebG 1329358..1329648 Escherichia coli SMS-3-5 6143310 YP_001743398.1 CDS EcSMS35_1340 NC_010498.1 1329703 1330071 D secreted protein; unknown function; hypothetical protein 1329703..1330071 Escherichia coli SMS-3-5 6144010 YP_001743399.1 CDS EcSMS35_1341 NC_010498.1 1330388 1331047 D identified by match to protein family HMM PF04391; hypothetical protein 1330388..1331047 Escherichia coli SMS-3-5 6144542 YP_001743400.1 CDS prtB NC_010498.1 1331254 1333314 D PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1331254..1333314 Escherichia coli SMS-3-5 6145994 YP_001743401.1 CDS exoX NC_010498.1 1333311 1333973 R 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X complement(1333311..1333973) Escherichia coli SMS-3-5 6147063 YP_001743402.1 CDS EcSMS35_1344 NC_010498.1 1333997 1334653 R identified by match to protein family HMM PF00795; carbon-nitrogen family hydrolase complement(1333997..1334653) Escherichia coli SMS-3-5 6145595 YP_001743403.1 CDS holE NC_010498.1 1334755 1334985 R identified by match to protein family HMM PF06440; DNA polymerase III subunit theta complement(1334755..1334985) Escherichia coli SMS-3-5 6142978 YP_001743404.1 CDS EcSMS35_1346 NC_010498.1 1335124 1335498 D identified by match to protein family HMM PF04234; hypothetical protein 1335124..1335498 Escherichia coli SMS-3-5 6144424 YP_001743405.1 CDS EcSMS35_1347 NC_010498.1 1335502 1336374 D identified by match to protein family HMM PF05425; copper resistance protein D 1335502..1336374 Escherichia coli SMS-3-5 6145043 YP_001743406.1 CDS EcSMS35_1348 NC_010498.1 1336387 1336728 D hypothetical protein 1336387..1336728 Escherichia coli SMS-3-5 6146620 YP_001743407.1 CDS pphA NC_010498.1 1337124 1337780 D Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 1337124..1337780 Escherichia coli SMS-3-5 6143786 YP_001743408.1 CDS EcSMS35_1350 NC_010498.1 1337781 1337972 R identified by match to protein family HMM PF07358; hypothetical protein complement(1337781..1337972) Escherichia coli SMS-3-5 6145727 YP_001743409.1 CDS EcSMS35_1351 NC_010498.1 1338077 1338313 R identified by match to protein family HMM PF07351; hypothetical protein complement(1338077..1338313) Escherichia coli SMS-3-5 6145067 YP_001743410.1 CDS yebU NC_010498.1 1338431 1339876 R in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF complement(1338431..1339876) Escherichia coli SMS-3-5 6147046 YP_001743411.1 CDS EcSMS35_1353 NC_010498.1 1339950 1342589 R identified by match to protein family HMM PF02470; mce-related protein complement(1339950..1342589) Escherichia coli SMS-3-5 6143238 YP_001743412.1 CDS EcSMS35_1354 NC_010498.1 1342552 1343790 R identified by match to protein family HMM PF04403; match to protein family HMM TIGR00155; PqiA family integral membrane protein complement(1342552..1343790) Escherichia coli SMS-3-5 6143516 YP_001743413.1 CDS EcSMS35_1355 NC_010498.1 1343911 1344462 D identified by match to protein family HMM PF01590; GAF domain-containing protein 1343911..1344462 Escherichia coli SMS-3-5 6142847 YP_001743414.1 CDS proQ NC_010498.1 1344559 1345257 D affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 1344559..1345257 Escherichia coli SMS-3-5 6145380 YP_001743415.1 CDS prc NC_010498.1 1345283 1347325 D Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1345283..1347325 Escherichia coli SMS-3-5 6147108 YP_001743416.1 CDS EcSMS35_1358 NC_010498.1 1347517 1348398 D putative metalloprotease; heat shock protein HtpX 1347517..1348398 Escherichia coli SMS-3-5 6146132 YP_001743417.1 CDS EcSMS35_1359 NC_010498.1 1348444 1349817 R identified by match to protein family HMM PF07690; major facilitator transporter complement(1348444..1349817) Escherichia coli SMS-3-5 6146574 YP_001743418.1 CDS kdgR NC_010498.1 1349994 1350785 D identified by match to protein family HMM PF01614; match to protein family HMM PF09339; transcriptional regulator KdgR 1349994..1350785 Escherichia coli SMS-3-5 6145003 YP_001743419.1 CDS EcSMS35_1361 NC_010498.1 1350929 1351168 R hypothetical protein complement(1350929..1351168) Escherichia coli SMS-3-5 6145522 YP_001743420.1 CDS EcSMS35_1362 NC_010498.1 1351327 1351470 D hypothetical protein 1351327..1351470 Escherichia coli SMS-3-5 6142988 YP_001743421.1 CDS EcSMS35_1363 NC_010498.1 1351545 1351832 D hypothetical protein 1351545..1351832 Escherichia coli SMS-3-5 6143992 YP_001743422.1 CDS EcSMS35_1364 NC_010498.1 1352502 1352645 D hypothetical protein 1352502..1352645 Escherichia coli SMS-3-5 6146909 YP_001743423.1 CDS cspC NC_010498.1 1352658 1352867 D identified by match to protein family HMM PF00313; cold shock-like protein CspC 1352658..1352867 Escherichia coli SMS-3-5 6142832 YP_001743424.1 CDS rrmA NC_010498.1 1353033 1353842 D methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1353033..1353842 Escherichia coli SMS-3-5 6147110 YP_001743425.1 CDS EcSMS35_1366 NC_010498.1 1353839 1354405 R membrane protein YebN; hypothetical protein complement(1353839..1354405) Escherichia coli SMS-3-5 6143049 YP_001743426.1 CDS EcSMS35_1368 NC_010498.1 1354834 1355292 R identified by match to protein family HMM PF06173; hypothetical protein complement(1354834..1355292) Escherichia coli SMS-3-5 6147480 YP_001743427.1 CDS manZ NC_010498.1 1355347 1356198 R hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID complement(1355347..1356198) Escherichia coli SMS-3-5 6147053 YP_001743428.1 CDS manY NC_010498.1 1356211 1357011 R identified by match to protein family HMM PF03609; match to protein family HMM TIGR00822; PTS system, mannose-specific IIC component complement(1356211..1357011) Escherichia coli SMS-3-5 6144202 YP_001743429.1 CDS manX NC_010498.1 1357074 1358045 R identified by match to protein family HMM PF03610; match to protein family HMM PF03830; match to protein family HMM TIGR00824; match to protein family HMM TIGR00854; PTS system, mannose-specific IIAB component complement(1357074..1358045) Escherichia coli SMS-3-5 6143134 YP_001743430.1 CDS EcSMS35_1372 NC_010498.1 1358508 1360064 D identified by match to protein family HMM PF00571; match to protein family HMM PF03471; match to protein family HMM PF03741; TerC family/CBS/transporter associated domain-containing protein 1358508..1360064 Escherichia coli SMS-3-5 6144448 YP_001743431.1 CDS EcSMS35_1373 NC_010498.1 1360068 1361666 R identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein complement(1360068..1361666) Escherichia coli SMS-3-5 6143788 YP_001743432.1 CDS sdaA NC_010498.1 1361797 1363161 R identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase 1 complement(1361797..1363161) Escherichia coli SMS-3-5 6145711 YP_001743433.1 CDS EcSMS35_1375 NC_010498.1 1363345 1363923 R identified by match to protein family HMM PF00293; hypothetical protein complement(1363345..1363923) Escherichia coli SMS-3-5 6145948 YP_001743434.1 CDS pabB NC_010498.1 1363927 1365288 R identified by match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553; aminodeoxychorismate synthase complement(1363927..1365288) Escherichia coli SMS-3-5 6144488 YP_001743435.1 CDS EcSMS35_1377 NC_010498.1 1365362 1365541 D identified by match to protein family HMM PF03701; hypothetical protein 1365362..1365541 Escherichia coli SMS-3-5 6143793 YP_001743436.1 CDS EcSMS35_1378 NC_010498.1 1365661 1365960 R identified by match to protein family HMM PF08986; hypothetical protein complement(1365661..1365960) Escherichia coli SMS-3-5 6145558 YP_001743437.1 CDS EcSMS35_1379 NC_010498.1 1366382 1366726 R identified by match to protein family HMM PF01042; endoribonuclease L-PSP family protein complement(1366382..1366726) Escherichia coli SMS-3-5 6145346 YP_001743438.1 CDS EcSMS35_1380 NC_010498.1 1366858 1368768 D hypothetical protein 1366858..1368768 Escherichia coli SMS-3-5 6145140 YP_001743439.1 CDS EcSMS35_1381 NC_010498.1 1368826 1369521 D identified by match to protein family HMM PF00814; glycoprotease family protein 1368826..1369521 Escherichia coli SMS-3-5 6147035 YP_001743440.1 CDS slp NC_010498.1 1369560 1370141 D identified by match to protein family HMM PF03843; match to protein family HMM TIGR00752; outer membrane protein Slp 1369560..1370141 Escherichia coli SMS-3-5 6143113 YP_001743441.1 CDS fadD NC_010498.1 1370346 1372031 D Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1370346..1372031 Escherichia coli SMS-3-5 6147374 YP_001743442.1 CDS rnd NC_010498.1 1372101 1373228 D identified by match to protein family HMM PF00570; match to protein family HMM PF01612; match to protein family HMM TIGR01388; ribonuclease D 1372101..1373228 Escherichia coli SMS-3-5 6144868 YP_001743443.1 CDS EcSMS35_1385 NC_010498.1 1373275 1374240 R identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; oxidoreductase, FAD/NAD-binding/iron-sulfur cluster binding protein complement(1373275..1374240) Escherichia coli SMS-3-5 6144179 YP_001743444.1 CDS EcSMS35_1386 NC_010498.1 1374296 1375420 R identified by match to protein family HMM PF00355; Rieske (2Fe-2S) domain-containing protein complement(1374296..1375420) Escherichia coli SMS-3-5 6144608 YP_001743445.1 CDS EcSMS35_1387 NC_010498.1 1375452 1377062 R member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; putative transporter complement(1375452..1377062) Escherichia coli SMS-3-5 6143964 YP_001743446.1 CDS ttuC NC_010498.1 1377313 1378398 R identified by match to protein family HMM PF00180; match to protein family HMM TIGR02089; tartrate dehydrogenase/decarboxylase complement(1377313..1378398) Escherichia coli SMS-3-5 6145597 YP_001743447.1 CDS EcSMS35_1389 NC_010498.1 1378501 1379424 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1378501..1379424 Escherichia coli SMS-3-5 6143821 YP_001743448.1 CDS EcSMS35_1390 NC_010498.1 1379551 1380189 D identified by match to protein family HMM PF01810; leucine export protein LeuE 1379551..1380189 Escherichia coli SMS-3-5 6145777 YP_001743449.1 CDS EcSMS35_1391 NC_010498.1 1380257 1380391 R identified by Glimmer3; putative; hypothetical protein complement(1380257..1380391) Escherichia coli SMS-3-5 6145155 YP_001743450.1 CDS EcSMS35_1392 NC_010498.1 1380362 1380721 D identified by match to protein family HMM PF09313; hypothetical protein 1380362..1380721 Escherichia coli SMS-3-5 6147074 YP_001743451.1 CDS EcSMS35_1393 NC_010498.1 1380725 1380907 D identified by match to protein family HMM PF08956; hypothetical protein 1380725..1380907 Escherichia coli SMS-3-5 6146527 YP_001743452.1 CDS EcSMS35_1394 NC_010498.1 1380924 1381043 D identified by Glimmer3; putative; hypothetical protein 1380924..1381043 Escherichia coli SMS-3-5 6143494 YP_001743453.1 CDS EcSMS35_1395 NC_010498.1 1381055 1381303 D identified by match to protein family HMM PF04226; hypothetical protein 1381055..1381303 Escherichia coli SMS-3-5 6142932 YP_001743454.1 CDS EcSMS35_1396 NC_010498.1 1381439 1381552 R identified by Glimmer3; putative; hypothetical protein complement(1381439..1381552) Escherichia coli SMS-3-5 6143505 YP_001743455.1 CDS EcSMS35_1397 NC_010498.1 1381570 1382595 R identified by match to protein family HMM PF00990; match to protein family HMM PF01590; match to protein family HMM TIGR00254; GAF domain/diguanylate cyclase domain-containing protein complement(1381570..1382595) Escherichia coli SMS-3-5 6142933 YP_001743456.1 CDS EcSMS35_1398 NC_010498.1 1382778 1383032 D identified by match to protein family HMM PF03891; putative lipoprotein 1382778..1383032 Escherichia coli SMS-3-5 6143811 YP_001743457.1 CDS EcSMS35_1399 NC_010498.1 1383054 1383401 R identified by match to protein family HMM PF04343; hypothetical protein complement(1383054..1383401) Escherichia coli SMS-3-5 6144095 YP_001743458.1 CDS yeaN NC_010498.1 1383456 1384637 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00896; inner membrane transport protein yeaN complement(1383456..1384637) Escherichia coli SMS-3-5 6145662 YP_001743459.1 CDS EcSMS35_1402 NC_010498.1 1384746 1385555 D identified by match to protein family HMM PF00165; AraC family transcriptional regulator 1384746..1385555 Escherichia coli SMS-3-5 6147305 YP_001743460.1 CDS EcSMS35_1401 NC_010498.1 1385512 1385958 R identified by match to protein family HMM PF04284; hypothetical protein complement(1385512..1385958) Escherichia coli SMS-3-5 6143327 YP_001743461.1 CDS EcSMS35_1403 NC_010498.1 1386080 1386232 D hypothetical protein 1386080..1386232 Escherichia coli SMS-3-5 6146779 YP_001743462.1 CDS EcSMS35_1404 NC_010498.1 1386233 1386736 R identified by match to protein family HMM PF04073; YbaK/prolyl-tRNA synthetase-associated domain-containing protein complement(1386233..1386736) Escherichia coli SMS-3-5 6142800 YP_001743463.1 CDS EcSMS35_1405 NC_010498.1 1386779 1388269 R identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase complement(1386779..1388269) Escherichia coli SMS-3-5 6143368 YP_001743464.1 CDS EcSMS35_1406 NC_010498.1 1388450 1389784 R identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase complement(1388450..1389784) Escherichia coli SMS-3-5 6142786 YP_001743465.1 CDS EcSMS35_1407 NC_010498.1 1390072 1391355 R identified by match to protein family HMM PF04285; hypothetical protein complement(1390072..1391355) Escherichia coli SMS-3-5 6144521 YP_001743466.1 CDS EcSMS35_1408 NC_010498.1 1391468 1393402 R identified by match to protein family HMM PF06798; match to protein family HMM PF08298; serine kinase family protein complement(1391468..1393402) Escherichia coli SMS-3-5 6143930 YP_001743467.1 CDS mipA NC_010498.1 1393838 1394584 D identified by match to protein family HMM PF06629; MltA-interacting protein MipA 1393838..1394584 Escherichia coli SMS-3-5 6143612 YP_001743468.1 CDS EcSMS35_1410 NC_010498.1 1394674 1395528 D identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 1394674..1395528 Escherichia coli SMS-3-5 6146509 YP_001743469.1 CDS EcSMS35_1411 NC_010498.1 1395579 1396463 R identified by match to protein family HMM PF01263; aldose 1-epimerase family protein complement(1395579..1396463) Escherichia coli SMS-3-5 6147294 YP_001743470.1 CDS gapA NC_010498.1 1396547 1397542 R identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; giyceraldehyde-3-phosphate dehydrogenase (phosphorylating) complement(1396547..1397542) Escherichia coli SMS-3-5 6145627 YP_001743471.1 CDS msrB NC_010498.1 1397884 1398297 D this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1397884..1398297 Escherichia coli SMS-3-5 6143783 YP_001743472.1 CDS EcSMS35_1414 NC_010498.1 1398339 1398611 D identified by match to protein family HMM PF07023; hypothetical protein 1398339..1398611 Escherichia coli SMS-3-5 6144609 YP_001743473.1 CDS EcSMS35_1415 NC_010498.1 1398981 1400057 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 1398981..1400057 Escherichia coli SMS-3-5 6142784 YP_001743474.1 CDS ydjK NC_010498.1 1400084 1401463 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 1400084..1401463 Escherichia coli SMS-3-5 6143322 YP_001743475.1 CDS gutB NC_010498.1 1401480 1402523 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; sorbitol dehydrogenase 1401480..1402523 Escherichia coli SMS-3-5 6142812 YP_001743476.1 CDS EcSMS35_1418 NC_010498.1 1402544 1403380 D identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; fructose-bisphosphate aldolase 1402544..1403380 Escherichia coli SMS-3-5 6143366 YP_001743477.1 CDS EcSMS35_1419 NC_010498.1 1403385 1404332 D identified by match to protein family HMM PF00294; PfkB family kinase 1403385..1404332 Escherichia coli SMS-3-5 6145545 YP_001743478.1 CDS EcSMS35_1420 NC_010498.1 1404342 1405322 D identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 1404342..1405322 Escherichia coli SMS-3-5 6143972 YP_001743479.1 CDS EcSMS35_1421 NC_010498.1 1405459 1406217 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator 1405459..1406217 Escherichia coli SMS-3-5 6144491 YP_001743480.1 CDS ydjE NC_010498.1 1406334 1407692 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 1406334..1407692 Escherichia coli SMS-3-5 6144689 YP_001743481.1 CDS pncA NC_010498.1 1407785 1408426 R catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase complement(1407785..1408426) Escherichia coli SMS-3-5 6142833 YP_001743482.1 CDS ansA NC_010498.1 1408437 1409453 R converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I complement(1408437..1409453) Escherichia coli SMS-3-5 6143005 YP_001743483.1 CDS sppA NC_010498.1 1409620 1411488 R SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 complement(1409620..1411488) Escherichia coli SMS-3-5 6146703 YP_001743484.1 CDS EcSMS35_1426 NC_010498.1 1411637 1412188 D identified by match to protein family HMM PF00881; hypothetical protein 1411637..1412188 Escherichia coli SMS-3-5 6142756 YP_001743485.1 CDS selD NC_010498.1 1412305 1413348 D catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1412305..1413348 Escherichia coli SMS-3-5 6146419 YP_001743486.1 CDS topB NC_010498.1 1413353 1415308 D decatenates replicating daughter chromosomes; DNA topoisomerase III 1413353..1415308 Escherichia coli SMS-3-5 6146168 YP_001743487.1 CDS gdhA NC_010498.1 1415385 1416728 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(1415385..1416728) Escherichia coli SMS-3-5 6147058 YP_001743488.1 CDS EcSMS35_1431 NC_010498.1 1416964 1417236 D identified by match to protein family HMM PF07383; hypothetical protein 1416964..1417236 Escherichia coli SMS-3-5 6145538 YP_001743489.1 CDS nudG NC_010498.1 1417202 1417609 R identified by match to protein family HMM PF00293; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase complement(1417202..1417609) Escherichia coli SMS-3-5 6142890 YP_001743490.1 CDS EcSMS35_1432 NC_010498.1 1417696 1418316 D identified by match to protein family HMM PF01066; CDP-alcohol phosphatidyltransferase family protein 1417696..1418316 Escherichia coli SMS-3-5 6143823 YP_001743491.1 CDS EcSMS35_1433 NC_010498.1 1418325 1419632 R rhodanese-like domain-containing protein complement(1418325..1419632) Escherichia coli SMS-3-5 6143601 YP_001743492.1 CDS EcSMS35_1434 NC_010498.1 1419699 1420352 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1419699..1420352) Escherichia coli SMS-3-5 6143424 YP_001743493.1 CDS ynjC NC_010498.1 1420352 1421887 R ABC transporter permease complement(1420352..1421887) Escherichia coli SMS-3-5 6146593 YP_001743494.1 CDS EcSMS35_1436 NC_010498.1 1421860 1423026 R putative ABC transporter solute-binding protein complement(1421860..1423026) Escherichia coli SMS-3-5 6147039 YP_001743495.1 CDS EcSMS35_1437 NC_010498.1 1423036 1423584 R identified by match to protein family HMM PF02627; carboxymuconolactone decarboxylase family protein complement(1423036..1423584) Escherichia coli SMS-3-5 6145254 YP_001743496.1 CDS EcSMS35_1438 NC_010498.1 1423584 1424291 R identified by match to protein family HMM PF09335; hypothetical protein complement(1423584..1424291) Escherichia coli SMS-3-5 6146510 YP_001743497.1 CDS EcSMS35_1439 NC_010498.1 1424306 1424983 R hypothetical protein complement(1424306..1424983) Escherichia coli SMS-3-5 6146979 YP_001743498.1 CDS EcSMS35_1440 NC_010498.1 1424988 1425698 R identified by match to protein family HMM PF09335; hypothetical protein complement(1424988..1425698) Escherichia coli SMS-3-5 6146266 YP_001743499.1 CDS xth NC_010498.1 1425865 1426671 R removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III complement(1425865..1426671) Escherichia coli SMS-3-5 6143095 YP_001743500.1 CDS EcSMS35_1442 NC_010498.1 1426684 1426854 R identified by Glimmer3; putative; hypothetical protein complement(1426684..1426854) Escherichia coli SMS-3-5 6147361 YP_001743501.1 CDS astC NC_010498.1 1427117 1428337 D catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1427117..1428337 Escherichia coli SMS-3-5 6144859 YP_001743502.1 CDS astA NC_010498.1 1428334 1429368 D identified by match to protein family HMM PF04958; match to protein family HMM TIGR03243; match to protein family HMM TIGR03244; arginine succinyltransferase 1428334..1429368 Escherichia coli SMS-3-5 6144195 YP_001743503.1 CDS astD NC_010498.1 1429365 1430843 D a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1429365..1430843 Escherichia coli SMS-3-5 6145919 YP_001743504.1 CDS astB NC_010498.1 1430840 1432183 D catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1430840..1432183 Escherichia coli SMS-3-5 6143852 YP_001743505.1 CDS astE NC_010498.1 1432176 1433144 D catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1432176..1433144 Escherichia coli SMS-3-5 6145669 YP_001743506.1 CDS spy NC_010498.1 1433474 1433959 D periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1433474..1433959 Escherichia coli SMS-3-5 6145195 YP_001743507.1 CDS EcSMS35_1450 NC_010498.1 1434162 1434737 D identified by match to protein family HMM PF05962; hypothetical protein 1434162..1434737 Escherichia coli SMS-3-5 6145183 YP_001743508.1 CDS cho NC_010498.1 1434697 1435584 R 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease complement(1434697..1435584) Escherichia coli SMS-3-5 6142688 YP_001743509.1 CDS nadE NC_010498.1 1435814 1436641 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1435814..1436641) Escherichia coli SMS-3-5 6143207 YP_001743510.1 CDS osmE NC_010498.1 1436843 1437181 D osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1436843..1437181 Escherichia coli SMS-3-5 6144647 YP_001743511.1 CDS chbB NC_010498.1 1437441 1437800 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1437441..1437800 Escherichia coli SMS-3-5 6144132 YP_001743512.1 CDS chbC NC_010498.1 1437885 1439243 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1437885..1439243 Escherichia coli SMS-3-5 6145980 YP_001743513.1 CDS chbA NC_010498.1 1439294 1439644 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1439294..1439644 Escherichia coli SMS-3-5 6145454 YP_001743514.1 CDS chbR NC_010498.1 1439655 1440494 D represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1439655..1440494 Escherichia coli SMS-3-5 6145034 YP_001743515.1 CDS chbF NC_010498.1 1440598 1441950 D identified by match to protein family HMM PF02056; 6-phospho-beta-glucosidase 1440598..1441950 Escherichia coli SMS-3-5 6146904 YP_001743516.1 CDS EcSMS35_1458 NC_010498.1 1441963 1442712 D identified by match to protein family HMM PF04794; hypothetical protein 1441963..1442712 Escherichia coli SMS-3-5 6144572 YP_001743517.1 CDS katE NC_010498.1 1442759 1445020 R Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II complement(1442759..1445020) Escherichia coli SMS-3-5 6146689 YP_001743518.1 CDS cedA NC_010498.1 1445224 1445466 D cell division modulator 1445224..1445466 Escherichia coli SMS-3-5 6144691 YP_001743519.1 CDS EcSMS35_1461 NC_010498.1 1445755 1446558 D hypothetical protein 1445755..1446558 Escherichia coli SMS-3-5 6145215 YP_001743520.1 CDS EcSMS35_1462 NC_010498.1 1446562 1447953 R identified by match to protein family HMM PF00375; sodium/dicarboxylate symporter family protein complement(1446562..1447953) Escherichia coli SMS-3-5 6147509 YP_001743521.1 CDS EcSMS35_1463 NC_010498.1 1448086 1448676 R identified by match to protein family HMM PF04307; hypothetical protein complement(1448086..1448676) Escherichia coli SMS-3-5 6143261 YP_001743522.1 CDS EcSMS35_1464 NC_010498.1 1448839 1449507 R YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase complement(1448839..1449507) Escherichia coli SMS-3-5 6146176 YP_001743523.1 CDS EcSMS35_1465 NC_010498.1 1449654 1450190 D hypothetical protein 1449654..1450190 Escherichia coli SMS-3-5 6146833 YP_001743524.1 CDS EcSMS35_1466 NC_010498.1 1450231 1451091 R identified by match to protein family HMM PF01636; match to protein family HMM PF03881; fructosamine kinase complement(1450231..1451091) Escherichia coli SMS-3-5 6146457 YP_001743525.1 CDS EcSMS35_1467 NC_010498.1 1451197 1451487 R hypothetical protein complement(1451197..1451487) Escherichia coli SMS-3-5 6147162 YP_001743526.1 CDS pfkB NC_010498.1 1451588 1452517 R identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 6-phosphofructokinase 2 complement(1451588..1452517) Escherichia coli SMS-3-5 6145096 YP_001743527.1 CDS EcSMS35_1469 NC_010498.1 1452804 1453562 D ydiY; identified by similarity to SP:P76206; match to protein family HMM PF04338; hypothetical protein 1452804..1453562 Escherichia coli SMS-3-5 6145137 YP_001743528.1 CDS EcSMS35_1470 NC_010498.1 1453615 1453833 R yniD; identified by similarity to SP:Q3Z269; hypothetical protein complement(1453615..1453833) Escherichia coli SMS-3-5 6144304 YP_001743529.1 CDS EcSMS35_1471 NC_010498.1 1453897 1455795 R identified by similarity to SP:P76205; match to protein family HMM PF07906; ankyrin repeat-containing protein complement(1453897..1455795) Escherichia coli SMS-3-5 6146032 YP_001743530.1 CDS thrS NC_010498.1 1456318 1458246 D catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1456318..1458246 Escherichia coli SMS-3-5 6147349 YP_001743531.1 CDS infC NC_010498.1 1458358 1458792 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1458358..1458792 Escherichia coli SMS-3-5 6144378 YP_001743532.1 CDS rpmI NC_010498.1 1458889 1459086 D identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 1458889..1459086 Escherichia coli SMS-3-5 6146398 YP_001743533.1 CDS rplT NC_010498.1 1459140 1459496 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1459140..1459496 Escherichia coli SMS-3-5 6143189 YP_001743534.1 CDS pheS NC_010498.1 1459802 1460785 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1459802..1460785 Escherichia coli SMS-3-5 6145905 YP_001743535.1 CDS pheT NC_010498.1 1460800 1463187 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1460800..1463187 Escherichia coli SMS-3-5 6145260 YP_001743536.1 CDS ihfA NC_010498.1 1463192 1463491 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1463192..1463491 Escherichia coli SMS-3-5 6145891 YP_001743537.1 CDS btuC NC_010498.1 1463592 1464572 D with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1463592..1464572 Escherichia coli SMS-3-5 6146064 YP_001743538.1 CDS btuE NC_010498.1 1464635 1465186 D similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase 1464635..1465186 Escherichia coli SMS-3-5 6142880 YP_001743539.1 CDS btuD NC_010498.1 1465186 1465935 D ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1465186..1465935 Escherichia coli SMS-3-5 6147266 YP_001743540.1 CDS EcSMS35_1482 NC_010498.1 1466013 1466477 D identified by match to protein family HMM PF00877; NlpC/P60 family lipoprotein 1466013..1466477 Escherichia coli SMS-3-5 6144554 YP_001743541.1 CDS EcSMS35_1483 NC_010498.1 1466724 1467437 D hypothetical protein 1466724..1467437 Escherichia coli SMS-3-5 6143908 YP_001743542.1 CDS EcSMS35_1484 NC_010498.1 1467500 1468936 D identified by match to protein family HMM PF02696; hypothetical protein 1467500..1468936 Escherichia coli SMS-3-5 6145673 YP_001743543.1 CDS EcSMS35_1485 NC_010498.1 1468940 1469158 R hypothetical protein complement(1468940..1469158) Escherichia coli SMS-3-5 6144968 YP_001743544.1 CDS aroH NC_010498.1 1469263 1470309 R tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1469263..1470309) Escherichia coli SMS-3-5 6145865 YP_001743545.1 CDS EcSMS35_1487 NC_010498.1 1470466 1471299 R identified by match to protein family HMM PF03618; hypothetical protein complement(1470466..1471299) Escherichia coli SMS-3-5 6145505 YP_001743546.1 CDS EcSMS35_1488 NC_010498.1 1471410 1471577 D identified by Glimmer3; putative; hypothetical protein 1471410..1471577 Escherichia coli SMS-3-5 6146982 YP_001743547.1 CDS ppsA NC_010498.1 1471631 1474009 D catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1471631..1474009 Escherichia coli SMS-3-5 6142753 YP_001743548.1 CDS EcSMS35_1490 NC_010498.1 1474498 1475898 D identified by similarity to SP:Q41364; match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; divalent anion:Na+ symporter (DASS) family protein 1474498..1475898 Escherichia coli SMS-3-5 6146530 YP_001743549.1 CDS EcSMS35_1491 NC_010498.1 1475934 1476893 D identified by match to protein family HMM PF00389; match to protein family HMM PF02826; D-isomer specific 2-hydroxyacid dehydrogenase family protein 1475934..1476893 Escherichia coli SMS-3-5 6147218 YP_001743550.1 CDS EcSMS35_1492 NC_010498.1 1476904 1477383 D identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1476904..1477383 Escherichia coli SMS-3-5 6145650 YP_001743551.1 CDS EcSMS35_1493 NC_010498.1 1477396 1478139 D identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase 1477396..1478139 Escherichia coli SMS-3-5 6146351 YP_001743552.1 CDS fadK NC_010498.1 1478190 1479830 R acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase complement(1478190..1479830) Escherichia coli SMS-3-5 6143828 YP_001743553.1 CDS EcSMS35_1495 NC_010498.1 1479887 1480180 R iron-sulfur cluster-binding protein complement(1479887..1480180) Escherichia coli SMS-3-5 6144353 YP_001743554.1 CDS EcSMS35_1496 NC_010498.1 1480177 1481466 R identified by similarity to SP:P68644; match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM PF03486; match to protein family HMM PF07992; hypothetical protein complement(1480177..1481466) Escherichia coli SMS-3-5 6142960 YP_001743555.1 CDS EcSMS35_1497 NC_010498.1 1481521 1482459 R May play a role in a redox process; electron transfer flavoprotein subunit YdiR complement(1481521..1482459) Escherichia coli SMS-3-5 6143512 YP_001743556.1 CDS EcSMS35_1498 NC_010498.1 1482479 1483243 R YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ complement(1482479..1483243) Escherichia coli SMS-3-5 6147100 YP_001743557.1 CDS EcSMS35_1499 NC_010498.1 1483280 1483456 D identified by Glimmer3; putative; hypothetical protein 1483280..1483456 Escherichia coli SMS-3-5 6146745 YP_001743558.1 CDS EcSMS35_1500 NC_010498.1 1483559 1484470 D identified by match to protein family HMM PF00165; match to protein family HMM PF02311; match to protein family HMM PF07883; AraC family transcriptional regulator 1483559..1484470 Escherichia coli SMS-3-5 6147217 YP_001743559.1 CDS EcSMS35_1501 NC_010498.1 1484513 1485667 R may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative acyl-CoA dehydrogenase complement(1484513..1485667) Escherichia coli SMS-3-5 6146670 YP_001743560.1 CDS pct NC_010498.1 1485678 1487273 R ydiF; identified by similarity to GB:CAB77207.1; match to protein family HMM PF01144; propionate CoA-transferase complement(1485678..1487273) Escherichia coli SMS-3-5 6143325 YP_001743561.1 CDS aroD NC_010498.1 1487419 1488177 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1487419..1488177) Escherichia coli SMS-3-5 6144564 YP_001743562.1 CDS EcSMS35_1504 NC_010498.1 1488208 1489074 R YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase complement(1488208..1489074) Escherichia coli SMS-3-5 6144662 YP_001743563.1 CDS EcSMS35_1505 NC_010498.1 1489086 1490351 R identified by match to protein family HMM PF07690; major facilitator transporter complement(1489086..1490351) Escherichia coli SMS-3-5 6144137 YP_001743564.1 CDS ydiM NC_010498.1 1490578 1491792 R identified by match to protein family HMM PF07690; major facilitator family transporter complement(1490578..1491792) Escherichia coli SMS-3-5 6146007 YP_001743565.1 CDS EcSMS35_1507 NC_010498.1 1491892 1492248 R identified by match to protein family HMM PF08965; hypothetical protein complement(1491892..1492248) Escherichia coli SMS-3-5 6145490 YP_001743566.1 CDS ydiK NC_010498.1 1492677 1493789 R YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; putative inner membrane protein complement(1492677..1493789) Escherichia coli SMS-3-5 6144935 YP_001743567.1 CDS EcSMS35_1509 NC_010498.1 1494178 1497234 D identified by match to protein family HMM PF01565; match to protein family HMM PF02913; oxidoreductase, FAD-binding 1494178..1497234 Escherichia coli SMS-3-5 6145016 YP_001743568.1 CDS ydiL NC_010498.1 1497231 1497641 D identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein 1497231..1497641 Escherichia coli SMS-3-5 6145707 YP_001743569.1 CDS EcSMS35_1511 NC_010498.1 1497741 1497929 D hypothetical protein 1497741..1497929 Escherichia coli SMS-3-5 6146347 YP_001743570.1 CDS sufA NC_010498.1 1498478 1498846 D functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1498478..1498846 Escherichia coli SMS-3-5 6146482 YP_001743571.1 CDS sufB NC_010498.1 1498855 1500342 D with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1498855..1500342 Escherichia coli SMS-3-5 6147175 YP_001743572.1 CDS sufC NC_010498.1 1500352 1501098 D part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase component 1500352..1501098 Escherichia coli SMS-3-5 6147471 YP_001743573.1 CDS sufD NC_010498.1 1501073 1502344 D with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1501073..1502344 Escherichia coli SMS-3-5 6143053 YP_001743574.1 CDS sufS NC_010498.1 1502341 1503561 D catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1502341..1503561 Escherichia coli SMS-3-5 6144297 YP_001743575.1 CDS sufE NC_010498.1 1503574 1503990 D Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1503574..1503990 Escherichia coli SMS-3-5 6144821 YP_001743576.1 CDS EcSMS35_1518 NC_010498.1 1504139 1505143 D identified by match to protein family HMM PF01476; match to protein family HMM PF03734; LysM/ErfK/YbiS/YcfS/YnhG family protein 1504139..1505143 Escherichia coli SMS-3-5 6144678 YP_001743577.1 CDS lpp NC_010498.1 1505207 1505443 R identified by match to protein family HMM PF04728; major outer membrane lipoprotein complement(1505207..1505443) Escherichia coli SMS-3-5 6146336 YP_001743578.1 CDS pykF NC_010498.1 1505754 1507166 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(1505754..1507166) Escherichia coli SMS-3-5 6146852 YP_001743579.1 CDS EcSMS35_1521 NC_010498.1 1507762 1507932 D hypothetical protein 1507762..1507932 Escherichia coli SMS-3-5 6142748 YP_001743580.1 CDS EcSMS35_1522 NC_010498.1 1508223 1508360 R identified by Glimmer3; putative; hypothetical protein complement(1508223..1508360) Escherichia coli SMS-3-5 6143187 YP_001743581.1 CDS EcSMS35_1523 NC_010498.1 1508388 1509014 D identified by match to protein family HMM PF00037; hypothetical protein 1508388..1509014 Escherichia coli SMS-3-5 6144106 YP_001743582.1 CDS EcSMS35_1524 NC_010498.1 1509035 1511137 D identified by match to protein family HMM PF01314; match to protein family HMM PF02730; putative oxidoreductase 1509035..1511137 Escherichia coli SMS-3-5 6144653 YP_001743583.1 CDS EcSMS35_1525 NC_010498.1 1511150 1511788 D hypothetical protein 1511150..1511788 Escherichia coli SMS-3-5 6145544 YP_001743584.1 CDS EcSMS35_1526 NC_010498.1 1511801 1512520 D identified by match to protein family HMM PF00037; iron-sulfur cluster-binding protein 1511801..1512520 Escherichia coli SMS-3-5 6146086 YP_001743585.1 CDS EcSMS35_1527 NC_010498.1 1512517 1513302 D identified by match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit 1512517..1513302 Escherichia coli SMS-3-5 6147017 YP_001743586.1 CDS EcSMS35_1528 NC_010498.1 1513306 1514118 D ydhT; identified by similarity to SP:P77147; hypothetical protein 1513306..1514118 Escherichia coli SMS-3-5 6144941 YP_001743587.1 CDS ydhR NC_010498.1 1515853 1516158 R identified by match to protein family HMM PF08803; hypothetical protein complement(1515853..1516158) Escherichia coli SMS-3-5 6145932 YP_001743588.1 CDS EcSMS35_1533 NC_010498.1 1516732 1517988 D hypothetical protein 1516732..1517988 Escherichia coli SMS-3-5 6143700 YP_001743589.1 CDS EcSMS35_1534 NC_010498.1 1518029 1519402 R NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein complement(1518029..1519402) Escherichia coli SMS-3-5 6146318 YP_001743590.1 CDS ribE NC_010498.1 1519617 1520258 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1519617..1520258 Escherichia coli SMS-3-5 6147015 YP_001743591.1 CDS cfa NC_010498.1 1520298 1521446 R catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase complement(1520298..1521446) Escherichia coli SMS-3-5 6143000 YP_001743592.1 CDS EcSMS35_1537 NC_010498.1 1521737 1522948 R uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC complement(1521737..1522948) Escherichia coli SMS-3-5 6146334 YP_001743593.1 CDS EcSMS35_1539 NC_010498.1 1523061 1523993 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 1523061..1523993 Escherichia coli SMS-3-5 6144792 YP_001743594.1 CDS purR NC_010498.1 1523990 1525015 R binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR complement(1523990..1525015) Escherichia coli SMS-3-5 6147195 YP_001743595.1 CDS EcSMS35_1540 NC_010498.1 1525284 1525403 D identified by Glimmer3; putative; membrane protein 1525284..1525403 Escherichia coli SMS-3-5 6147394 YP_001743596.1 CDS EcSMS35_1541 NC_010498.1 1525569 1526738 D identified by match to protein family HMM PF07690; major facilitator transporter 1525569..1526738 Escherichia coli SMS-3-5 6146502 YP_001743597.1 CDS sodB NC_010498.1 1526884 1527465 R SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase complement(1526884..1527465) Escherichia coli SMS-3-5 6143608 YP_001743598.1 CDS EcSMS35_1543 NC_010498.1 1527593 1528420 R identified by match to protein family HMM PF00877; NlpC/P60 family protein complement(1527593..1528420) Escherichia coli SMS-3-5 6142903 YP_001743599.1 CDS EcSMS35_1544 NC_010498.1 1528755 1529102 D identified by match to protein family HMM PF00462; match to protein family HMM TIGR00365; hypothetical protein 1528755..1529102 Escherichia coli SMS-3-5 6147407 YP_001743600.1 CDS lhr NC_010498.1 1529153 1533769 R similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; putative ATP-dependent helicase Lhr complement(1529153..1533769) Escherichia coli SMS-3-5 6144548 YP_001743601.1 CDS rnt NC_010498.1 1533862 1534509 R Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T complement(1533862..1534509) Escherichia coli SMS-3-5 6143918 YP_001743602.1 CDS gloA NC_010498.1 1534612 1535019 R Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I complement(1534612..1535019) Escherichia coli SMS-3-5 6145946 YP_001743603.1 CDS nemA NC_010498.1 1535100 1536197 R FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase complement(1535100..1536197) Escherichia coli SMS-3-5 6144423 YP_001743604.1 CDS EcSMS35_1549 NC_010498.1 1536234 1536833 R identified by match to protein family HMM PF00440; TetR family transcriptional regulator complement(1536234..1536833) Escherichia coli SMS-3-5 6142871 YP_001743605.1 CDS EcSMS35_1550 NC_010498.1 1536798 1537175 D identified by match to protein family HMM PF06945; hypothetical protein 1536798..1537175 Escherichia coli SMS-3-5 6147455 YP_001743606.1 CDS ydhF NC_010498.1 1537224 1538120 D identified by match to protein family HMM PF00248; oxidoreductase YdhF 1537224..1538120 Escherichia coli SMS-3-5 6147345 YP_001743607.1 CDS sodC_1 NC_010498.1 1538201 1538722 D SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1538201..1538722 Escherichia coli SMS-3-5 6143234 YP_001743608.1 CDS EcSMS35_1553 NC_010498.1 1538723 1540735 R identified by match to protein family HMM PF04632; fusaric acid resistance domain-containing protein complement(1538723..1540735) Escherichia coli SMS-3-5 6146271 YP_001743609.1 CDS EcSMS35_1554 NC_010498.1 1540735 1541592 R identified by match to protein family HMM PF00529; MFP family transporter complement(1540735..1541592) Escherichia coli SMS-3-5 6147156 YP_001743610.1 CDS EcSMS35_1555 NC_010498.1 1541595 1541831 R identified by match to protein family HMM PF07869; hypothetical protein complement(1541595..1541831) Escherichia coli SMS-3-5 6145377 YP_001743611.1 CDS EcSMS35_1556 NC_010498.1 1541888 1542007 D identified by Glimmer3; putative; hypothetical protein 1541888..1542007 Escherichia coli SMS-3-5 6145848 YP_001743612.1 CDS EcSMS35_1557 NC_010498.1 1542032 1542466 D Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1542032..1542466 Escherichia coli SMS-3-5 6144280 YP_001743613.1 CDS slyB NC_010498.1 1542513 1542980 R identified by match to protein family HMM PF05433; outer membrane lipoprotein SlyB complement(1542513..1542980) Escherichia coli SMS-3-5 6147433 YP_001743614.1 CDS anmK NC_010498.1 1543254 1544363 D catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1543254..1544363 Escherichia coli SMS-3-5 6145602 YP_001743615.1 CDS EcSMS35_1560 NC_010498.1 1544461 1544790 D MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1544461..1544790 Escherichia coli SMS-3-5 6144944 YP_001743616.1 CDS pdxH NC_010498.1 1544849 1545505 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1544849..1545505 Escherichia coli SMS-3-5 6144638 YP_001743617.1 CDS tyrS NC_010498.1 1545634 1546908 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1545634..1546908 Escherichia coli SMS-3-5 6144125 YP_001743618.1 CDS pdxY NC_010498.1 1546970 1547830 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1546970..1547830 Escherichia coli SMS-3-5 6143214 YP_001743619.1 CDS gst NC_010498.1 1547874 1548479 R identified by similarity to SP:P0A9D2; match to protein family HMM PF00043; match to protein family HMM PF02798; glutathionine S-transferase complement(1547874..1548479) Escherichia coli SMS-3-5 6142686 YP_001743620.1 CDS tppB NC_010498.1 1548584 1550086 R mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease complement(1548584..1550086) Escherichia coli SMS-3-5 6146773 YP_001743621.1 CDS nth NC_010498.1 1550696 1551331 R DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III complement(1550696..1551331) Escherichia coli SMS-3-5 6146309 YP_001743622.1 CDS rnfE NC_010498.1 1551331 1552026 R in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit complement(1551331..1552026) Escherichia coli SMS-3-5 6145565 YP_001743623.1 CDS rnfG NC_010498.1 1552030 1552650 R part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG complement(1552030..1552650) Escherichia coli SMS-3-5 6145035 YP_001743624.1 CDS rnfD NC_010498.1 1552654 1553712 R RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD complement(1552654..1553712) Escherichia coli SMS-3-5 6146430 YP_001743625.1 CDS rnfC NC_010498.1 1553713 1555743 R part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC complement(1553713..1555743) Escherichia coli SMS-3-5 6147157 YP_001743626.1 CDS rnfB NC_010498.1 1555736 1556314 R part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB complement(1555736..1556314) Escherichia coli SMS-3-5 6146552 YP_001743627.1 CDS rnfA NC_010498.1 1556314 1556895 R identified by similarity to SP:P0A766; match to protein family HMM PF02508; match to protein family HMM TIGR01943; Na(+)-translocating NADH-quinone reductase subunit E complement(1556314..1556895) Escherichia coli SMS-3-5 6147091 YP_001743628.1 CDS EcSMS35_1573 NC_010498.1 1556972 1557412 R hypothetical protein complement(1556972..1557412) Escherichia coli SMS-3-5 6145174 YP_001743629.1 CDS EcSMS35_1574 NC_010498.1 1557498 1557713 R YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein complement(1557498..1557713) Escherichia coli SMS-3-5 6145681 YP_001743630.1 CDS EcSMS35_1575 NC_010498.1 1558354 1559394 D identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; putative oxidoreductase 1558354..1559394 Escherichia coli SMS-3-5 6143838 YP_001743631.1 CDS add NC_010498.1 1559430 1560431 R catalyzes the formation of inosine from adenosine; adenosine deaminase complement(1559430..1560431) Escherichia coli SMS-3-5 6144345 YP_001743632.1 CDS malY NC_010498.1 1560535 1561707 R identified by similarity to SP:P23256; match to protein family HMM PF00155; maltose regulon modulator MalY complement(1560535..1561707) Escherichia coli SMS-3-5 6143442 YP_001743633.1 CDS malX NC_010498.1 1561717 1563309 R phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB complement(1561717..1563309) Escherichia coli SMS-3-5 6146635 YP_001743634.1 CDS malI NC_010498.1 1563484 1564512 D regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1563484..1564512 Escherichia coli SMS-3-5 6145867 YP_001743635.1 CDS EcSMS35_1580 NC_010498.1 1564624 1565391 D Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1564624..1565391 Escherichia coli SMS-3-5 6145692 YP_001743636.1 CDS uidR NC_010498.1 1565631 1566209 D identified by match to protein family HMM PF00440; transcriptional regulator UidR 1565631..1566209 Escherichia coli SMS-3-5 6144814 YP_001743637.1 CDS uidA NC_010498.1 1566599 1568410 D identified by match to protein family HMM PF00703; match to protein family HMM PF02836; match to protein family HMM PF02837; beta-D-glucuronidase 1566599..1568410 Escherichia coli SMS-3-5 6144065 YP_001743638.1 CDS uidB NC_010498.1 1568407 1569780 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00792; glucuronide transporter 1568407..1569780 Escherichia coli SMS-3-5 6143046 YP_001743639.1 CDS uidC NC_010498.1 1569837 1571084 D putative outer membrane porin protein 1569837..1571084 Escherichia coli SMS-3-5 6147410 YP_001743640.1 CDS EcSMS35_1585 NC_010498.1 1571129 1572637 R identified by match to protein family HMM PF06097; hypothetical protein complement(1571129..1572637) Escherichia coli SMS-3-5 6146897 YP_001743641.1 CDS manA NC_010498.1 1572738 1573913 R identified by similarity to SP:P00946; match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase, class I complement(1572738..1573913) Escherichia coli SMS-3-5 6146341 YP_001743642.1 CDS fumA NC_010498.1 1574112 1575758 D identified by similarity to SP:P0AC33; match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; fumarate hydratase 1574112..1575758 Escherichia coli SMS-3-5 6146518 YP_001743643.1 CDS fumC NC_010498.1 1575901 1577304 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1575901..1577304 Escherichia coli SMS-3-5 6146349 YP_001743644.1 CDS tus NC_010498.1 1577301 1578242 R binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein complement(1577301..1578242) Escherichia coli SMS-3-5 6145503 YP_001743645.1 CDS rstB NC_010498.1 1578306 1579607 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein RstB complement(1578306..1579607) Escherichia coli SMS-3-5 6144669 YP_001743646.1 CDS rstA NC_010498.1 1579611 1580330 R response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA complement(1579611..1580330) Escherichia coli SMS-3-5 6146951 YP_001743647.1 CDS EcSMS35_1593 NC_010498.1 1580459 1580794 D identified by match to protein family HMM PF06942; hypothetical protein 1580459..1580794 Escherichia coli SMS-3-5 6147457 YP_001743648.1 CDS EcSMS35_1592 NC_010498.1 1580791 1581513 R identified by match to protein family HMM PF00106; short chain dehydrogenase complement(1580791..1581513) Escherichia coli SMS-3-5 6144188 YP_001743649.1 CDS arcD NC_010498.1 1581550 1582932 R identified by match to protein family HMM PF00324; match to protein family HMM TIGR00905; arginine/ornithine antiporter complement(1581550..1582932) Escherichia coli SMS-3-5 6143054 YP_001743650.1 CDS ydgH NC_010498.1 1583118 1584062 R identified by match to protein family HMM PF07338; YdgH protein complement(1583118..1584062) Escherichia coli SMS-3-5 6144726 YP_001743651.1 CDS pntA NC_010498.1 1584587 1586119 D forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1584587..1586119 Escherichia coli SMS-3-5 6145281 YP_001743652.1 CDS pntB NC_010498.1 1586130 1587518 D catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1586130..1587518 Escherichia coli SMS-3-5 6146406 YP_001743653.1 CDS tqsA NC_010498.1 1587543 1588577 R transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; putative transport protein complement(1587543..1588577) Escherichia coli SMS-3-5 6146931 YP_001743654.1 CDS mdtJ NC_010498.1 1588989 1589354 D with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1588989..1589354 Escherichia coli SMS-3-5 6147353 YP_001743655.1 CDS mdtI NC_010498.1 1589341 1589670 D with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1589341..1589670 Escherichia coli SMS-3-5 6142896 YP_001743656.1 CDS EcSMS35_1601 NC_010498.1 1589709 1590530 R identified by match to protein family HMM PF00089; S1A family peptidase complement(1589709..1590530) Escherichia coli SMS-3-5 6147193 YP_001743657.1 CDS EcSMS35_1602 NC_010498.1 1590806 1591078 R required for growth and survival under moderately acid conditions; acid shock protein precursor complement(1590806..1591078) Escherichia coli SMS-3-5 6143341 YP_001743658.1 CDS EcSMS35_1603 NC_010498.1 1591190 1592398 D identified by match to protein family HMM PF01609; IS10 transposase 1591190..1592398 Escherichia coli SMS-3-5 6145825 YP_001743659.1 CDS ynfM NC_010498.1 1592877 1594130 R identified by match to protein family HMM PF07690; major facilitator family transporter complement(1592877..1594130) Escherichia coli SMS-3-5 6145345 YP_001743660.1 CDS EcSMS35_1605 NC_010498.1 1594237 1595130 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1594237..1595130 Escherichia coli SMS-3-5 6144272 YP_001743661.1 CDS mic NC_010498.1 1595265 1596485 D identified by match to protein family HMM PF00480; transcriptional regulator Mic 1595265..1596485 Escherichia coli SMS-3-5 6144397 YP_001743662.1 CDS bioD2 NC_010498.1 1596610 1597305 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase 1596610..1597305 Escherichia coli SMS-3-5 6143919 YP_001743663.1 CDS EcSMS35_1607 NC_010498.1 1597258 1598514 R identified by match to protein family HMM PF00654; putative voltage-gated ClC-type chloride channel ClcB complement(1597258..1598514) Escherichia coli SMS-3-5 6143300 YP_001743664.1 CDS dmsD NC_010498.1 1598709 1599323 R binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD complement(1598709..1599323) Escherichia coli SMS-3-5 6146967 YP_001743665.1 CDS dmsC2 NC_010498.1 1599366 1600220 R identified by match to protein family HMM PF04976; anaerobic dimethyl sulfoxide reductase, C subunit complement(1599366..1600220) Escherichia coli SMS-3-5 6144458 YP_001743666.1 CDS dmsB_1 NC_010498.1 1600222 1600839 R identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951; dimethylsulfoxide reductase, B subunit complement(1600222..1600839) Escherichia coli SMS-3-5 6144828 YP_001743667.1 CDS ynfE NC_010498.1 1603333 1605759 R identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166; anaerobic dimethyl sulfoxide reductase, A subunit YnfE complement(1603333..1605759) Escherichia coli SMS-3-5 6147198 YP_001743668.1 CDS EcSMS35_1614 NC_010498.1 1605958 1606263 R identified by match to protein family HMM PF06649; hypothetical protein complement(1605958..1606263) Escherichia coli SMS-3-5 6146421 YP_001743669.1 CDS EcSMS35_1615 NC_010498.1 1606335 1607081 D identified by match to protein family HMM PF06788; hypothetical protein 1606335..1607081 Escherichia coli SMS-3-5 6145731 YP_001743670.1 CDS speG NC_010498.1 1607084 1607644 R identified by match to protein family HMM PF00583; diamine N-acetyltransferase complement(1607084..1607644) Escherichia coli SMS-3-5 6145069 YP_001743671.1 CDS EcSMS35_1617 NC_010498.1 1607679 1608020 R identified by match to protein family HMM PF06932; hypothetical protein complement(1607679..1608020) Escherichia coli SMS-3-5 6147207 YP_001743672.1 CDS EcSMS35_1618 NC_010498.1 1608155 1608481 D identified by match to protein family HMM PF02694; hypothetical protein 1608155..1608481 Escherichia coli SMS-3-5 6144721 YP_001743673.1 CDS rspA NC_010498.1 1608687 1609901 D identified by match to protein family HMM PF01188; match to protein family HMM PF02746; starvation-sensing protein RspA 1608687..1609901 Escherichia coli SMS-3-5 6142908 YP_001743674.1 CDS rspB NC_010498.1 1609913 1610932 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; putative dehydrogenase 1609913..1610932 Escherichia coli SMS-3-5 6143563 YP_001743675.1 CDS ydfJ NC_010498.1 1610990 1612357 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; inner membrane metabolite transport protein ydfJ 1610990..1612357 Escherichia coli SMS-3-5 6146155 YP_001743676.1 CDS EcSMS35_1622 NC_010498.1 1612320 1612436 D identified by Glimmer3; putative; hypothetical protein 1612320..1612436 Escherichia coli SMS-3-5 6144939 YP_001743677.1 CDS EcSMS35_1623 NC_010498.1 1612446 1613906 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase family protein 1612446..1613906 Escherichia coli SMS-3-5 6145606 YP_001743678.1 CDS EcSMS35_1624 NC_010498.1 1613942 1614145 R identified by match to protein family HMM TIGR03318; hypothetical protein complement(1613942..1614145) Escherichia coli SMS-3-5 6144020 YP_001743679.1 CDS EcSMS35_1625 NC_010498.1 1614322 1615008 R identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator complement(1614322..1615008) Escherichia coli SMS-3-5 6144100 YP_001743680.1 CDS EcSMS35_1626 NC_010498.1 1615097 1615843 R NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase complement(1615097..1615843) Escherichia coli SMS-3-5 6144097 YP_001743681.1 CDS dcp NC_010498.1 1615980 1618025 D identified by match to protein family HMM PF01432; dipeptidyl carboxypeptidase II 1615980..1618025 Escherichia coli SMS-3-5 6144950 YP_001743682.1 CDS EcSMS35_1628 NC_010498.1 1618388 1618780 D ydeI; identified by match to protein family HMM PF04076; match to protein family HMM TIGR00156; hypothetical protein 1618388..1618780 Escherichia coli SMS-3-5 6145581 YP_001743683.1 CDS EcSMS35_1629 NC_010498.1 1619035 1619925 D identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; hypothetical protein 1619035..1619925 Escherichia coli SMS-3-5 6146024 YP_001743684.1 CDS ydeE NC_010498.1 1620366 1621553 R YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE complement(1620366..1621553) Escherichia coli SMS-3-5 6146188 YP_001743685.1 CDS eamA NC_010498.1 1621748 1622647 D identified by match to protein family HMM PF00892; match to protein family HMM PF03151; O-acetylserine/cysteine export protein 1621748..1622647 Escherichia coli SMS-3-5 6146801 YP_001743686.1 CDS EcSMS35_1632 NC_010498.1 1622692 1623390 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(1622692..1623390) Escherichia coli SMS-3-5 6147112 YP_001743687.1 CDS EcSMS35_1633 NC_010498.1 1623589 1623900 D identified by match to protein family HMM PF02302; PTS system lactose/cellobiose family IIB subunit 1623589..1623900 Escherichia coli SMS-3-5 6145494 YP_001743688.1 CDS EcSMS35_1634 NC_010498.1 1624014 1625336 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system lactose/cellobiose family IIC subunit 1624014..1625336 Escherichia coli SMS-3-5 6143947 YP_001743689.1 CDS EcSMS35_1635 NC_010498.1 1625364 1625675 D identified by match to protein family HMM PF02255; PTS system lactose/cellobiose-specific family IIA subunit 1625364..1625675 Escherichia coli SMS-3-5 6144632 YP_001743690.1 CDS bglH NC_010498.1 1625731 1627404 D identified by similarity to SP:P26218; match to protein family HMM PF02264; glucoside specific outer membrane porin BglH 1625731..1627404 Escherichia coli SMS-3-5 6142642 YP_001743691.1 CDS celA NC_010498.1 1627429 1628868 D converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 1627429..1628868 Escherichia coli SMS-3-5 6144754 YP_001743692.1 CDS marB NC_010498.1 1628925 1629143 R hypothetical protein complement(1628925..1629143) Escherichia coli SMS-3-5 6147304 YP_001743693.1 CDS marA NC_010498.1 1629175 1629558 R transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA complement(1629175..1629558) Escherichia coli SMS-3-5 6146634 YP_001743694.1 CDS marR NC_010498.1 1629579 1630013 R Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR complement(1629579..1630013) Escherichia coli SMS-3-5 6143534 YP_001743695.1 CDS marC NC_010498.1 1630225 1630890 D protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1630225..1630890 Escherichia coli SMS-3-5 6142700 YP_001743696.1 CDS sotB NC_010498.1 1630915 1632105 R identified by match to protein family HMM PF07690; sugar efflux transporter complement(1630915..1632105) Escherichia coli SMS-3-5 6144457 YP_001743697.1 CDS EcSMS35_1643 NC_010498.1 1632023 1632145 D identified by Glimmer3; putative; hypothetical protein 1632023..1632145 Escherichia coli SMS-3-5 6144222 YP_001743698.1 CDS EcSMS35_1645 NC_010498.1 1632182 1632301 D identified by Glimmer3; putative; hypothetical protein 1632182..1632301 Escherichia coli SMS-3-5 6145652 YP_001743699.1 CDS EcSMS35_1644 NC_010498.1 1632255 1633370 R hypothetical protein complement(1632255..1633370) Escherichia coli SMS-3-5 6145657 YP_001743700.1 CDS EcSMS35_1646 NC_010498.1 1633448 1634329 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(1633448..1634329) Escherichia coli SMS-3-5 6145161 YP_001743701.1 CDS EcSMS35_1647 NC_010498.1 1634430 1635818 D in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase 1634430..1635818 Escherichia coli SMS-3-5 6146287 YP_001743702.1 CDS glsA2 NC_010498.1 1635882 1636808 D catalyzes the formation of glutamate from glutamine; glutaminase 1635882..1636808 Escherichia coli SMS-3-5 6143386 YP_001743703.1 CDS EcSMS35_1649 NC_010498.1 1636808 1637167 D hypothetical protein 1636808..1637167 Escherichia coli SMS-3-5 6142711 YP_001743704.1 CDS EcSMS35_1650 NC_010498.1 1637306 1638724 D identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1637306..1638724 Escherichia coli SMS-3-5 6143487 YP_001743705.1 CDS uxaB NC_010498.1 1638952 1640403 D catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1638952..1640403 Escherichia coli SMS-3-5 6142958 YP_001743706.1 CDS EcSMS35_1652 NC_010498.1 1640600 1641514 D identified by match to protein family HMM PF05249; hypothetical protein 1640600..1641514 Escherichia coli SMS-3-5 6143742 YP_001743707.1 CDS tam NC_010498.1 1641518 1642276 R catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase complement(1641518..1642276) Escherichia coli SMS-3-5 6145569 YP_001743708.1 CDS lsrG NC_010498.1 1642333 1642623 R identified by match to protein family HMM PF03992; autoinducer-2 (AI-2) modifying protein LsrG complement(1642333..1642623) Escherichia coli SMS-3-5 6145360 YP_001743709.1 CDS lsrF NC_010498.1 1642647 1643522 R identified by match to protein family HMM PF01791; aldolase complement(1642647..1643522) Escherichia coli SMS-3-5 6146914 YP_001743710.1 CDS lsrB NC_010498.1 1643549 1644571 R autoinducer-2 ABC transporter periplasmic autoinducer-2-binding protein LsrB complement(1643549..1644571) Escherichia coli SMS-3-5 6146664 YP_001743711.1 CDS lsrD NC_010498.1 1644583 1645575 R identified by match to protein family HMM PF02653; autoinducer-2 ABC transporter permease LsrD complement(1644583..1645575) Escherichia coli SMS-3-5 6143198 YP_001743712.1 CDS lsrC NC_010498.1 1645575 1646603 R identified by match to protein family HMM PF02653; autoinducer-2 ABC transporter permease LsrC complement(1645575..1646603) Escherichia coli SMS-3-5 6145153 YP_001743713.1 CDS lsrA NC_010498.1 1646597 1648132 R identified by match to protein family HMM PF00005; autoinducer-2 ABC transporter ATP-binding protein LsrA complement(1646597..1648132) Escherichia coli SMS-3-5 6145712 YP_001743714.1 CDS lsrR NC_010498.1 1648381 1649334 D identified by match to protein family HMM PF04198; transcriptional repressor LsrR 1648381..1649334 Escherichia coli SMS-3-5 6143880 YP_001743715.1 CDS lsrK NC_010498.1 1649413 1651005 D identified by match to protein family HMM PF00370; match to protein family HMM PF02782; autoinducer-2 (AI-2) kinase 1649413..1651005 Escherichia coli SMS-3-5 6144365 YP_001743716.1 CDS EcSMS35_1662 NC_010498.1 1651535 1656415 D ydeK; identified by match to protein family HMM PF03212; match to protein family HMM TIGR02601; pertactin family protein 1651535..1656415 Escherichia coli SMS-3-5 6142868 YP_001743717.1 CDS EcSMS35_1663 NC_010498.1 1656724 1656846 D identified by Glimmer3; putative; hypothetical protein 1656724..1656846 Escherichia coli SMS-3-5 6143385 YP_001743718.1 CDS EcSMS35_1664 NC_010498.1 1657614 1658177 D identified by match to protein family HMM PF00419; fimbrial protein 1657614..1658177 Escherichia coli SMS-3-5 6146422 YP_001743719.1 CDS EcSMS35_1665 NC_010498.1 1658540 1659250 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; periplasmic pilus chaperone family protein 1658540..1659250 Escherichia coli SMS-3-5 6146415 YP_001743720.1 CDS EcSMS35_1666 NC_010498.1 1659328 1661943 D identified by match to protein family HMM PF00577; fimbrial usher family protein 1659328..1661943 Escherichia coli SMS-3-5 6142997 YP_001743721.1 CDS EcSMS35_1667 NC_010498.1 1661957 1662487 D identified by match to protein family HMM PF00419; protein FimF-like protein 1661957..1662487 Escherichia coli SMS-3-5 6143948 YP_001743722.1 CDS EcSMS35_1669 NC_010498.1 1662500 1663147 D ydeR; identified by similarity to SP:P08190; match to protein family HMM PF00419; protein FimG-like protein 1662500..1663147 Escherichia coli SMS-3-5 6143438 YP_001743723.1 CDS EcSMS35_1668 NC_010498.1 1662987 1663892 R identified by match to protein family HMM PF00665; IS2 transposase orfB complement(1662987..1663892) Escherichia coli SMS-3-5 6146862 YP_001743724.1 CDS EcSMS35_1670 NC_010498.1 1663850 1664260 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(1663850..1664260) Escherichia coli SMS-3-5 6143399 YP_001743725.1 CDS EcSMS35_1671 NC_010498.1 1664399 1665313 D identified by match to protein family HMM PF00419; match to protein family HMM PF09160; protein FimH-like protein 1664399..1665313 Escherichia coli SMS-3-5 6142702 YP_001743726.1 CDS EcSMS35_1672 NC_010498.1 1665652 1667931 D in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase 1665652..1667931 Escherichia coli SMS-3-5 6147252 YP_001743727.1 CDS EcSMS35_1673 NC_010498.1 1668179 1668376 D identified by similarity to SP:Q7UCH6; hypothetical protein 1668179..1668376 Escherichia coli SMS-3-5 6146578 YP_001743728.1 CDS EcSMS35_1674 NC_010498.1 1668451 1669212 D regulates the cellular response to acid resistance; transcriptional regulator YdeO 1668451..1669212 Escherichia coli SMS-3-5 6144978 YP_001743729.1 CDS EcSMS35_1675 NC_010498.1 1669676 1671295 D identified by match to protein family HMM PF00884; sulfatase 1669676..1671295 Escherichia coli SMS-3-5 6144597 YP_001743730.1 CDS EcSMS35_1676 NC_010498.1 1671347 1672504 D identified by match to protein family HMM PF04055; radical SAM domain-containing protein 1671347..1672504 Escherichia coli SMS-3-5 6143933 YP_001743731.1 CDS EcSMS35_1677 NC_010498.1 1672795 1674480 D identified by match to protein family HMM PF00005; match to protein family HMM PF05992; match to protein family HMM PF06472; inner membrane ABC transporter ATP-binding protein 1672795..1674480 Escherichia coli SMS-3-5 6146441 YP_001743732.1 CDS EcSMS35_1678 NC_010498.1 1674518 1676890 D identified by match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 1674518..1676890 Escherichia coli SMS-3-5 6146423 YP_001743733.1 CDS pqqL NC_010498.1 1676947 1679730 D identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16B family peptidase 1676947..1679730 Escherichia coli SMS-3-5 6145570 YP_001743734.1 CDS gadA NC_010498.1 1680092 1681492 D identified by match to protein family HMM PF00282; match to protein family HMM TIGR01788; glutamate decarboxylase GadA 1680092..1681492 Escherichia coli SMS-3-5 6145213 YP_001743735.1 CDS gadC NC_010498.1 1681648 1683183 D identified by match to protein family HMM PF00324; match to protein family HMM TIGR00910; glutamate:gamma aminobutyrate antiporter 1681648..1683183 Escherichia coli SMS-3-5 6144205 YP_001743736.1 CDS EcSMS35_1682 NC_010498.1 1683419 1684633 D identified by match to protein family HMM PF02638; putative lipoprotein 1683419..1684633 Escherichia coli SMS-3-5 6143883 YP_001743737.1 CDS EcSMS35_1683 NC_010498.1 1685009 1686391 D identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1685009..1686391 Escherichia coli SMS-3-5 6142740 YP_001743738.1 CDS dos NC_010498.1 1686392 1688815 D heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1686392..1688815 Escherichia coli SMS-3-5 6147322 YP_001743739.1 CDS ddpX NC_010498.1 1689073 1689654 D catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 1689073..1689654 Escherichia coli SMS-3-5 6142732 YP_001743740.1 CDS EcSMS35_1686 NC_010498.1 1689668 1691218 D identified by match to protein family HMM PF00496; putative ABC transporter periplasmic-binding protein yddS precursor 1689668..1691218 Escherichia coli SMS-3-5 6145053 YP_001743741.1 CDS yddR NC_010498.1 1691220 1692242 D identified by match to protein family HMM PF00528; inner membrane ABC transporter permease yddR 1691220..1692242 Escherichia coli SMS-3-5 6145251 YP_001743742.1 CDS yddQ NC_010498.1 1692239 1693135 D identified by match to protein family HMM PF00528; ATP-dependent peptide transporter membrane subunit 1692239..1693135 Escherichia coli SMS-3-5 6146099 YP_001743743.1 CDS EcSMS35_1689 NC_010498.1 1693132 1694118 D identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; ABC transporter ATP-binding protein 1693132..1694118 Escherichia coli SMS-3-5 6145414 YP_001743744.1 CDS EcSMS35_1690 NC_010498.1 1694111 1695037 D identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; putative ABC transport system ATP-binding protein 1694111..1695037 Escherichia coli SMS-3-5 6145906 YP_001743745.1 CDS osmC NC_010498.1 1695093 1695443 R identified by match to protein family HMM PF02566; peroxiredoxin OsmC complement(1695093..1695443) Escherichia coli SMS-3-5 6144377 YP_001743746.1 CDS EcSMS35_1692 NC_010498.1 1695561 1695701 R identified by Glimmer3; putative; hypothetical protein complement(1695561..1695701) Escherichia coli SMS-3-5 6144889 YP_001743747.1 CDS EcSMS35_1693 NC_010498.1 1695868 1696083 D biofilm-dependent modulation protein 1695868..1696083 Escherichia coli SMS-3-5 6147495 YP_001743748.1 CDS rpsV NC_010498.1 1696185 1696322 D protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 1696185..1696322 Escherichia coli SMS-3-5 6143088 YP_001743749.1 CDS sfcA NC_010498.1 1696479 1698176 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1696479..1698176 Escherichia coli SMS-3-5 6146449 YP_001743750.1 CDS EcSMS35_1696 NC_010498.1 1698310 1699320 D similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1698310..1699320 Escherichia coli SMS-3-5 6146311 YP_001743751.1 CDS EcSMS35_1697 NC_010498.1 1699466 1699750 D identified by match to protein family HMM PF01381; match to protein family HMM TIGR02607; addiction module antidote protein 1699466..1699750 Escherichia coli SMS-3-5 6145778 YP_001743752.1 CDS fdnI NC_010498.1 1699801 1700454 R nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma complement(1699801..1700454) Escherichia coli SMS-3-5 6145125 YP_001743753.1 CDS fdnH NC_010498.1 1700447 1701331 R identified by match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582; formate dehydrogenase, nitrate-inducible, iron-sulfur subunit complement(1700447..1701331) Escherichia coli SMS-3-5 6146454 YP_001743754.1 CDS fdnG NC_010498.1 1701344 1704391 R Selenoprotein. identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; formate dehydrogenase, nitrate inducible, alpha subunit, selenocysteine-containing complement(1701344..1704391) Escherichia coli SMS-3-5 6146074 YP_001743755.1 CDS EcSMS35_1701 NC_010498.1 1704623 1705504 D identified by match to protein family HMM PF00892; hypothetical protein 1704623..1705504 Escherichia coli SMS-3-5 6143545 YP_001743756.1 CDS EcSMS35_1702 NC_010498.1 1705762 1706862 D identified by similarity to SP:P77747; match to protein family HMM PF00267; porin family protein 1705762..1706862 Escherichia coli SMS-3-5 6144352 YP_001743757.1 CDS EcSMS35_1703 NC_010498.1 1707032 1708291 D identified by similarity to GB:ABB61785.1; hypothetical protein 1707032..1708291 Escherichia coli SMS-3-5 6143842 YP_001743758.1 CDS EcSMS35_1704 NC_010498.1 1708354 1709610 D identified by similarity to RF:NP_837403.1; hypothetical protein 1708354..1709610 Escherichia coli SMS-3-5 6145086 YP_001743759.1 CDS narU NC_010498.1 1709920 1711308 D identified by similarity to SP:P37758; match to protein family HMM PF07690; match to protein family HMM TIGR00886; nitrite extrusion protein 2 1709920..1711308 Escherichia coli SMS-3-5 6143194 YP_001743760.1 CDS narZ NC_010498.1 1711403 1715143 D identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; nitrate reductase 2, alpha subunit 1711403..1715143 Escherichia coli SMS-3-5 6146263 YP_001743761.1 CDS narY NC_010498.1 1715140 1716684 D identified by similarity to SP:P19318; match to protein family HMM TIGR01660; nitrate reductase 2, beta subunit 1715140..1716684 Escherichia coli SMS-3-5 6146791 YP_001743762.1 CDS narW NC_010498.1 1716684 1717379 D identified by similarity to SP:P19317; match to protein family HMM PF02613; match to protein family HMM TIGR00684; nitrate reductase molybdenum cofactor assembly chaperone 2 1716684..1717379 Escherichia coli SMS-3-5 6142781 YP_001743763.1 CDS narV NC_010498.1 1717376 1718056 D identified by similarity to SP:P0AF32; match to protein family HMM PF02665; match to protein family HMM TIGR00351; respiratory nitrate reductase 2, gamma subunit 1717376..1718056 Escherichia coli SMS-3-5 6143272 YP_001743764.1 CDS EcSMS35_1710 NC_010498.1 1718136 1719029 D identified by match to protein family HMM PF02567; match to protein family HMM TIGR00654; hypothetical protein 1718136..1719029 Escherichia coli SMS-3-5 6146169 YP_001743765.1 CDS EcSMS35_1711 NC_010498.1 1719125 1719970 R identified by match to protein family HMM PF00797; N-hydroxyarylamine O-acetyltransferase complement(1719125..1719970) Escherichia coli SMS-3-5 6146812 YP_001743766.1 CDS EcSMS35_1712 NC_010498.1 1720145 1720714 D identified by match to protein family HMM PF01613; flavin reductase domain-containing protein 1720145..1720714 Escherichia coli SMS-3-5 6145607 YP_001743767.1 CDS EcSMS35_1713 NC_010498.1 1720718 1720945 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(1720718..1720945) Escherichia coli SMS-3-5 6146104 YP_001743768.1 CDS EcSMS35_1714 NC_010498.1 1721250 1723226 D identified by match to protein family HMM PF00753; metallo-beta-lactamase family protein 1721250..1723226 Escherichia coli SMS-3-5 6144119 YP_001743769.1 CDS EcSMS35_1715 NC_010498.1 1723202 1723339 D identified by Glimmer3; putative; hypothetical protein 1723202..1723339 Escherichia coli SMS-3-5 6147229 YP_001743770.1 CDS EcSMS35_1716 NC_010498.1 1723321 1724370 D identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1723321..1724370 Escherichia coli SMS-3-5 6143472 YP_001743771.1 CDS EcSMS35_1717 NC_010498.1 1724371 1724988 R identified by similarity to GB:ABB62052.1; hypothetical protein complement(1724371..1724988) Escherichia coli SMS-3-5 6144154 YP_001743772.1 CDS ansP NC_010498.1 1725255 1726754 D identified by match to protein family HMM PF00324; L-asparagine permease 1725255..1726754 Escherichia coli SMS-3-5 6143914 YP_001743773.1 CDS EcSMS35_1719 NC_010498.1 1726867 1727928 R hypothetical protein complement(1726867..1727928) Escherichia coli SMS-3-5 6145277 YP_001743774.1 CDS EcSMS35_1720 NC_010498.1 1728170 1730272 D identified by match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 1728170..1730272 Escherichia coli SMS-3-5 6144855 YP_001743775.1 CDS EcSMS35_1721 NC_010498.1 1730308 1730973 R identified by match to protein family HMM PF00392; match to protein family HMM PF07729; putative DNA-binding transcriptional regulator complement(1730308..1730973) Escherichia coli SMS-3-5 6144925 YP_001743776.1 CDS EcSMS35_1722 NC_010498.1 1730972 1731103 D identified by Glimmer3; putative; hypothetical protein 1730972..1731103 Escherichia coli SMS-3-5 6145953 YP_001743777.1 CDS EcSMS35_1724 NC_010498.1 1731072 1731197 D identified by Glimmer3; putative; hypothetical protein 1731072..1731197 Escherichia coli SMS-3-5 6146610 YP_001743778.1 CDS EcSMS35_1723 NC_010498.1 1731172 1732209 R identified by match to protein family HMM PF00107; zinc-binding dehydrogenase family oxidoreductase complement(1731172..1732209) Escherichia coli SMS-3-5 6143118 YP_001743779.1 CDS EcSMS35_1725 NC_010498.1 1732390 1732908 D identified by match to protein family HMM PF00583; acetyltransferase 1732390..1732908 Escherichia coli SMS-3-5 6146972 YP_001743780.1 CDS EcSMS35_1726 NC_010498.1 1732905 1733354 D identified by match to protein family HMM PF04657; hypothetical protein 1732905..1733354 Escherichia coli SMS-3-5 6144475 YP_001743781.1 CDS EcSMS35_1727 NC_010498.1 1733355 1733588 R hypothetical protein complement(1733355..1733588) Escherichia coli SMS-3-5 6143808 YP_001743782.1 CDS EcSMS35_1728 NC_010498.1 1733674 1733922 R hypothetical protein complement(1733674..1733922) Escherichia coli SMS-3-5 6145770 YP_001743783.1 CDS EcSMS35_1730 NC_010498.1 1734121 1734237 D identified by Glimmer3; putative; hypothetical protein 1734121..1734237 Escherichia coli SMS-3-5 6145942 YP_001743784.1 CDS ydcW NC_010498.1 1734234 1735658 R catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase complement(1734234..1735658) Escherichia coli SMS-3-5 6146236 YP_001743785.1 CDS ydcV NC_010498.1 1735680 1736474 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1735680..1736474) Escherichia coli SMS-3-5 6145700 YP_001743786.1 CDS ydcU NC_010498.1 1736464 1737405 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1736464..1737405) Escherichia coli SMS-3-5 6146787 YP_001743787.1 CDS ydcT NC_010498.1 1737406 1738419 R identified by match to protein family HMM PF00005; match to protein family HMM PF08402; ABC transporter ATP-binding protein complement(1737406..1738419) Escherichia coli SMS-3-5 6142952 YP_001743788.1 CDS ydcS NC_010498.1 1738437 1739582 R identified by match to protein family HMM PF01547; ABC transporter periplasmic substrate-binding protein complement(1738437..1739582) Escherichia coli SMS-3-5 6144278 YP_001743789.1 CDS EcSMS35_1735 NC_010498.1 1739827 1741233 R identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator complement(1739827..1741233) Escherichia coli SMS-3-5 6145643 YP_001743790.1 CDS EcSMS35_1736 NC_010498.1 1741312 1741749 R identified by match to protein family HMM PF01381; match to protein family HMM PF03681; hypothetical protein complement(1741312..1741749) Escherichia coli SMS-3-5 6146665 YP_001743791.1 CDS EcSMS35_1737 NC_010498.1 1741993 1742115 D identified by Glimmer3; putative; hypothetical protein 1741993..1742115 Escherichia coli SMS-3-5 6147064 YP_001743792.1 CDS EcSMS35_1738 NC_010498.1 1742232 1742402 D hypothetical protein 1742232..1742402 Escherichia coli SMS-3-5 6145299 YP_001743793.1 CDS EcSMS35_1739 NC_010498.1 1742494 1744455 R identified by match to protein family HMM PF01136; U32 family peptidase complement(1742494..1744455) Escherichia coli SMS-3-5 6145647 YP_001743794.1 CDS EcSMS35_1740 NC_010498.1 1744528 1745064 R identified by match to protein family HMM PF01381; match to protein family HMM PF07883; DNA-binding protein complement(1744528..1745064) Escherichia coli SMS-3-5 6144561 YP_001743795.1 CDS EcSMS35_1742 NC_010498.1 1745063 1746055 D identified by match to protein family HMM PF03594; match to protein family HMM TIGR00843; benzoate transporter 1745063..1746055 Escherichia coli SMS-3-5 6144930 YP_001743796.1 CDS EcSMS35_1741 NC_010498.1 1746052 1747380 R identified by match to protein family HMM PF01609; IS4 transposase complement(1746052..1747380) Escherichia coli SMS-3-5 6143489 YP_001743797.1 CDS EcSMS35_1743 NC_010498.1 1747487 1747765 D identified by match to protein family HMM PF03594; benzoate membrane transport protein 1747487..1747765 Escherichia coli SMS-3-5 6143101 YP_001743798.1 CDS EcSMS35_1744 NC_010498.1 1747800 1748468 R putative lipoprotein complement(1747800..1748468) Escherichia coli SMS-3-5 6147326 YP_001743799.1 CDS tehB NC_010498.1 1748771 1749364 R with TehA confers resistance to tellurite; tellurite resistance protein TehB complement(1748771..1749364) Escherichia coli SMS-3-5 6144524 YP_001743800.1 CDS tehA NC_010498.1 1749361 1750353 R identified by match to protein family HMM PF03595; match to protein family HMM TIGR00816; potassium-tellurite ethidium and proflavin transporter complement(1749361..1750353) Escherichia coli SMS-3-5 6145173 YP_001743801.1 CDS EcSMS35_1748 NC_010498.1 1750477 1751457 D hypothetical protein 1750477..1751457 Escherichia coli SMS-3-5 6146604 YP_001743802.1 CDS rimL NC_010498.1 1751449 1751988 R identified by match to protein family HMM PF00583; ribosomal-protein-L7/L12-serine acetyltransferase complement(1751449..1751988) Escherichia coli SMS-3-5 6144332 YP_001743803.1 CDS EcSMS35_1749 NC_010498.1 1752051 1752275 R identified by match to protein family HMM PF04325; hypothetical protein complement(1752051..1752275) Escherichia coli SMS-3-5 6143951 YP_001743804.1 CDS mdoD NC_010498.1 1752415 1754034 R involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D complement(1752415..1754034) Escherichia coli SMS-3-5 6143428 YP_001743805.1 CDS EcSMS35_1751 NC_010498.1 1754295 1755638 R identified by match to protein family HMM PF07063; hypothetical protein complement(1754295..1755638) Escherichia coli SMS-3-5 6143902 YP_001743806.1 CDS EcSMS35_1752 NC_010498.1 1755855 1756778 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1755855..1756778 Escherichia coli SMS-3-5 6147289 YP_001743807.1 CDS trg NC_010498.1 1756817 1758457 R identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein III complement(1756817..1758457) Escherichia coli SMS-3-5 6142692 YP_001743808.1 CDS EcSMS35_1754 NC_010498.1 1759077 1759250 R hypothetical protein complement(1759077..1759250) Escherichia coli SMS-3-5 6146609 YP_001743809.1 CDS EcSMS35_1755 NC_010498.1 1759495 1760061 R B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 complement(1759495..1760061) Escherichia coli SMS-3-5 6143232 YP_001743810.1 CDS gapC NC_010498.1 1760214 1761215 D identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1760214..1761215 Escherichia coli SMS-3-5 6143907 YP_001743811.1 CDS aldA NC_010498.1 1761256 1762695 R NAD-linked; aldehyde dehydrogenase A complement(1761256..1762695) Escherichia coli SMS-3-5 6144472 YP_001743812.1 CDS EcSMS35_1758 NC_010498.1 1762892 1763692 R identified by match to protein family HMM PF02698; hypothetical protein complement(1762892..1763692) Escherichia coli SMS-3-5 6144937 YP_001743813.1 CDS hrpA NC_010498.1 1763965 1767867 R involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA complement(1763965..1767867) Escherichia coli SMS-3-5 6145514 YP_001743814.1 CDS azoR NC_010498.1 1768068 1768673 D FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1768068..1768673 Escherichia coli SMS-3-5 6143474 YP_001743815.1 CDS EcSMS35_1761 NC_010498.1 1768727 1770019 R identified by match to protein family HMM PF00782; match to protein family HMM PF01569; PAP2 family protein complement(1768727..1770019) Escherichia coli SMS-3-5 6146547 YP_001743816.1 CDS EcSMS35_1762 NC_010498.1 1770033 1771790 R hypothetical protein complement(1770033..1771790) Escherichia coli SMS-3-5 6144629 YP_001743817.1 CDS cdsA2 NC_010498.1 1771806 1772702 R identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase complement(1771806..1772702) Escherichia coli SMS-3-5 6142622 YP_001743818.1 CDS EcSMS35_1764 NC_010498.1 1772702 1773307 R identified by match to protein family HMM PF01066; CDP-alcohol phosphatidyltransferase family protein complement(1772702..1773307) Escherichia coli SMS-3-5 6145663 YP_001743819.1 CDS EcSMS35_1765 NC_010498.1 1773477 1775783 R hypothetical protein complement(1773477..1775783) Escherichia coli SMS-3-5 6144687 YP_001743820.1 CDS EcSMS35_1766 NC_010498.1 1775847 1776707 R identified by match to protein family HMM PF00248; putative oxidoreductase complement(1775847..1776707) Escherichia coli SMS-3-5 6146590 YP_001743821.1 CDS EcSMS35_1767 NC_010498.1 1776915 1782869 R identified by match to protein family HMM PF03797; putative autotransporter complement(1776915..1782869) Escherichia coli SMS-3-5 6143039 YP_001743822.1 CDS EcSMS35_1768 NC_010498.1 1783327 1783650 R identified by similarity to GB:CAD01687.1; match to protein family HMM PF07027; hypothetical protein complement(1783327..1783650) Escherichia coli SMS-3-5 6145048 YP_001743823.1 CDS EcSMS35_1769 NC_010498.1 1783658 1783843 R putative lipoprotein complement(1783658..1783843) Escherichia coli SMS-3-5 6146816 YP_001743824.1 CDS EcSMS35_1770 NC_010498.1 1783840 1786479 R hypothetical protein complement(1783840..1786479) Escherichia coli SMS-3-5 6143987 YP_001743825.1 CDS idhA NC_010498.1 1786687 1787676 D identified by match to protein family HMM PF00389; match to protein family HMM PF02826; D-lactate dehydrogenase 1786687..1787676 Escherichia coli SMS-3-5 6145272 YP_001743826.1 CDS hslJ NC_010498.1 1787787 1788209 D identified by match to protein family HMM PF03724; heat-inducible protein 1787787..1788209 Escherichia coli SMS-3-5 6144735 YP_001743827.1 CDS EcSMS35_1772 NC_010498.1 1788206 1788331 R putative lipoprotein complement(1788206..1788331) Escherichia coli SMS-3-5 6142993 YP_001743828.1 CDS EcSMS35_1774 NC_010498.1 1788559 1788675 D identified by Glimmer3; putative; hypothetical protein 1788559..1788675 Escherichia coli SMS-3-5 6144250 YP_001743829.1 CDS ydbK NC_010498.1 1788746 1792270 D identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176; pyruvate-flavodoxin oxidoreductase 1788746..1792270 Escherichia coli SMS-3-5 6144308 YP_001743830.1 CDS ompN NC_010498.1 1792636 1793754 D identified by similarity to SP:P77747; match to protein family HMM PF00267; outer membrane protein N 1792636..1793754 Escherichia coli SMS-3-5 6147494 YP_001743831.1 CDS uspF NC_010498.1 1793895 1794329 D identified by match to protein family HMM PF00582; universal stress protein F 1793895..1794329 Escherichia coli SMS-3-5 6144442 YP_001743832.1 CDS EcSMS35_1778 NC_010498.1 1794505 1795440 D TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1794505..1795440 Escherichia coli SMS-3-5 6146500 YP_001743833.1 CDS dbpA NC_010498.1 1795569 1796942 R exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA complement(1795569..1796942) Escherichia coli SMS-3-5 6143287 YP_001743834.1 CDS zntB NC_010498.1 1797420 1798403 R identified by match to protein family HMM PF01544; zinc transporter complement(1797420..1798403) Escherichia coli SMS-3-5 6145512 YP_001743835.1 CDS EcSMS35_1781 NC_010498.1 1798598 1799890 D identified by match to protein family HMM PF00990; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254; sensory box-containing diguanylate cyclase 1798598..1799890 Escherichia coli SMS-3-5 6147213 YP_001743836.1 CDS EcSMS35_1782 NC_010498.1 1799911 1800474 R identified by match to protein family HMM PF01713; Smr domain-containing protein complement(1799911..1800474) Escherichia coli SMS-3-5 6145628 YP_001743837.1 CDS abgR NC_010498.1 1800805 1801713 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator complement(1800805..1801713) Escherichia coli SMS-3-5 6144965 YP_001743838.1 CDS abgA NC_010498.1 1801898 1803199 D identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; aminobenzoyl-glutamate utilization protein A 1801898..1803199 Escherichia coli SMS-3-5 6147178 YP_001743839.1 CDS abgB NC_010498.1 1803199 1804644 D identified by match to protein family HMM PF01546; match to protein family HMM TIGR01891; aminobenzoyl-glutamate utilization protein B 1803199..1804644 Escherichia coli SMS-3-5 6144073 YP_001743840.1 CDS abgT NC_010498.1 1804675 1806207 D identified by match to protein family HMM PF03806; match to protein family HMM TIGR00819; putative aminobenzoyl-glutamate transporter 1804675..1806207 Escherichia coli SMS-3-5 6146842 YP_001743841.1 CDS ogt NC_010498.1 1806218 1806733 D identified by match to protein family HMM PF01035; match to protein family HMM PF02870; match to protein family HMM TIGR00589; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1806218..1806733 Escherichia coli SMS-3-5 6142602 YP_001743842.1 CDS fnr NC_010498.1 1806928 1807680 D Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1806928..1807680 Escherichia coli SMS-3-5 6146055 YP_001743843.1 CDS uspE NC_010498.1 1807832 1808782 D with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1807832..1808782 Escherichia coli SMS-3-5 6146129 YP_001743844.1 CDS EcSMS35_1790 NC_010498.1 1808832 1809089 R hypothetical protein complement(1808832..1809089) Escherichia coli SMS-3-5 6145403 YP_001743845.1 CDS EcSMS35_1791 NC_010498.1 1809333 1810364 D identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel family protein 1809333..1810364 Escherichia coli SMS-3-5 6146083 YP_001743846.1 CDS mppA NC_010498.1 1810415 1812028 R identified by match to protein family HMM PF00496; periplasmic murein peptide-binding protein complement(1810415..1812028) Escherichia coli SMS-3-5 6144050 YP_001743847.1 CDS EcSMS35_1793 NC_010498.1 1812365 1813264 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(1812365..1813264) Escherichia coli SMS-3-5 6144734 YP_001743848.1 CDS EcSMS35_1794 NC_010498.1 1813402 1814322 D identified by match to protein family HMM PF02129; hypothetical protein 1813402..1814322 Escherichia coli SMS-3-5 6145385 YP_001743849.1 CDS EcSMS35_1795 NC_010498.1 1814393 1815031 D identified by match to protein family HMM PF05368; NmrA family protein 1814393..1815031 Escherichia coli SMS-3-5 6145434 YP_001743850.1 CDS EcSMS35_1797 NC_010498.1 1815322 1816050 D identified by match to protein family HMM PF00246; murein peptide amidase A 1815322..1816050 Escherichia coli SMS-3-5 6145447 YP_001743851.1 CDS EcSMS35_1796 NC_010498.1 1816025 1816990 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein complement(1816025..1816990) Escherichia coli SMS-3-5 6146138 YP_001743852.1 CDS tpx NC_010498.1 1817109 1817615 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1817109..1817615 Escherichia coli SMS-3-5 6146107 YP_001743853.1 CDS tyrR NC_010498.1 1817659 1819200 R regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR complement(1817659..1819200) Escherichia coli SMS-3-5 6146845 YP_001743854.1 CDS EcSMS35_1800 NC_010498.1 1819348 1820409 R ycjF; identified by match to protein family HMM PF05128; match to protein family HMM TIGR01620; hypothetical protein complement(1819348..1820409) Escherichia coli SMS-3-5 6145955 YP_001743855.1 CDS EcSMS35_1801 NC_010498.1 1820406 1821803 R identified by match to protein family HMM PF04317; hypothetical protein complement(1820406..1821803) Escherichia coli SMS-3-5 6145443 YP_001743856.1 CDS EcSMS35_1802 NC_010498.1 1821947 1822945 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcription regulator 1821947..1822945 Escherichia coli SMS-3-5 6146752 YP_001743857.1 CDS ompG NC_010498.1 1822996 1823901 R identified by similarity to SP:P76045; monomeric porin OmpG complement(1822996..1823901) Escherichia coli SMS-3-5 6146205 YP_001743858.1 CDS EcSMS35_1804 NC_010498.1 1823946 1825028 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; sugar ABC transporter ATP-binding protein complement(1823946..1825028) Escherichia coli SMS-3-5 6147420 YP_001743859.1 CDS pgmB NC_010498.1 1825042 1825701 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR01990; match to protein family HMM TIGR02009; beta-phosphoglucomutase complement(1825042..1825701) Escherichia coli SMS-3-5 6144993 YP_001743860.1 CDS EcSMS35_1806 NC_010498.1 1825698 1827965 R identified by match to protein family HMM PF03632; match to protein family HMM PF03633; match to protein family HMM PF03636; glycosyl hydrolase family protein complement(1825698..1827965) Escherichia coli SMS-3-5 6146197 YP_001743861.1 CDS EcSMS35_1807 NC_010498.1 1827962 1829005 R identified by match to protein family HMM PF01408; match to protein family HMM PF02894; gfo/idh/mocA family protein complement(1827962..1829005) Escherichia coli SMS-3-5 6146707 YP_001743862.1 CDS EcSMS35_1808 NC_010498.1 1829027 1829815 R identified by match to protein family HMM PF01261; AP endonuclease complement(1829027..1829815) Escherichia coli SMS-3-5 6143506 YP_001743863.1 CDS EcSMS35_1809 NC_010498.1 1829833 1830885 R identified by match to protein family HMM PF00107; zinc-binding dehydrogenase family oxidoreductase complement(1829833..1830885) Escherichia coli SMS-3-5 6142743 YP_001743864.1 CDS EcSMS35_1810 NC_010498.1 1830916 1831758 R identified by match to protein family HMM PF00528; putative sugar ABC transporter permease complement(1830916..1831758) Escherichia coli SMS-3-5 6145630 YP_001743865.1 CDS EcSMS35_1811 NC_010498.1 1831745 1832626 R identified by match to protein family HMM PF00528; putative sugar ABC transporter permease complement(1831745..1832626) Escherichia coli SMS-3-5 6146289 YP_001743866.1 CDS EcSMS35_1812 NC_010498.1 1832647 1833939 R identified by match to protein family HMM PF01547; putative sugar ABC transporter periplasmic sugar-binding protein complement(1832647..1833939) Escherichia coli SMS-3-5 6146963 YP_001743867.1 CDS EcSMS35_1813 NC_010498.1 1833953 1835632 R identified by match to protein family HMM PF00128; alpha amylase family protein complement(1833953..1835632) Escherichia coli SMS-3-5 6142721 YP_001743868.1 CDS pspE NC_010498.1 1835846 1836160 R rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase complement(1835846..1836160) Escherichia coli SMS-3-5 6144033 YP_001743869.1 CDS pspD NC_010498.1 1836235 1836456 R identified by match to protein family HMM TIGR02979; peripheral inner membrane phage-shock protein complement(1836235..1836456) Escherichia coli SMS-3-5 6146259 YP_001743870.1 CDS pspC NC_010498.1 1836465 1836824 R with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC complement(1836465..1836824) Escherichia coli SMS-3-5 6142807 YP_001743871.1 CDS pspB NC_010498.1 1836824 1837048 R acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B complement(1836824..1837048) Escherichia coli SMS-3-5 6143587 YP_001743872.1 CDS pspA NC_010498.1 1837102 1837770 R involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA complement(1837102..1837770) Escherichia coli SMS-3-5 6147051 YP_001743873.1 CDS pspF NC_010498.1 1837937 1838914 D transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1837937..1838914 Escherichia coli SMS-3-5 6145159 YP_001743874.1 CDS gabT1 NC_010498.1 1839045 1840310 R putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase complement(1839045..1840310) Escherichia coli SMS-3-5 6143459 YP_001743875.1 CDS puuB NC_010498.1 1840348 1841628 R identified by match to protein family HMM PF01266; gamma-glutamylputrescine oxidoreductase complement(1840348..1841628) Escherichia coli SMS-3-5 6146507 YP_001743876.1 CDS puuC NC_010498.1 1841630 1843117 R catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase complement(1841630..1843117) Escherichia coli SMS-3-5 6143841 YP_001743877.1 CDS puuR NC_010498.1 1843267 1843824 R regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR complement(1843267..1843824) Escherichia coli SMS-3-5 6144339 YP_001743878.1 CDS puuD NC_010498.1 1843851 1844603 R catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase complement(1843851..1844603) Escherichia coli SMS-3-5 6145147 YP_001743879.1 CDS puuA NC_010498.1 1844827 1846245 D identified by match to protein family HMM PF00120; glutamate--putrescine ligase 1844827..1846245 Escherichia coli SMS-3-5 6143766 YP_001743880.1 CDS EcSMS35_1826 NC_010498.1 1846548 1847933 D identified by match to protein family HMM PF00324; amino acid permease 1846548..1847933 Escherichia coli SMS-3-5 6146424 YP_001743881.1 CDS EcSMS35_1827 NC_010498.1 1848067 1848312 D hypothetical protein 1848067..1848312 Escherichia coli SMS-3-5 6147189 YP_001743882.1 CDS sapA NC_010498.1 1848649 1850268 D identified by match to protein family HMM PF00496; peptide ABC transporter periplasmic peptide-binding protein 1848649..1850268 Escherichia coli SMS-3-5 6142891 YP_001743883.1 CDS sapB NC_010498.1 1850265 1851230 D identified by match to protein family HMM PF00528; peptide ABC transporter permease SapB 1850265..1851230 Escherichia coli SMS-3-5 6143603 YP_001743884.1 CDS sapC NC_010498.1 1851217 1852107 D identified by match to protein family HMM PF00528; peptide ABC transporter permease SapC 1851217..1852107 Escherichia coli SMS-3-5 6147464 YP_001743885.1 CDS sapD NC_010498.1 1852107 1853099 D identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; peptide ABC transporter ATP-binding protein SapD 1852107..1853099 Escherichia coli SMS-3-5 6143579 YP_001743886.1 CDS sapF NC_010498.1 1853101 1853907 D identified by similarity to SP:P36638; match to protein family HMM PF00005; peptide transport system, ATP-binding protein SapF 1853101..1853907 Escherichia coli SMS-3-5 6143774 YP_001743887.1 CDS eefD NC_010498.1 1853956 1855119 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710; multidrug efflux transport protein EefD complement(1853956..1855119) Escherichia coli SMS-3-5 6144437 YP_001743888.1 CDS eefC NC_010498.1 1855128 1856501 R identified by similarity to GB:CAD48863.1; match to protein family HMM PF02321; match to protein family HMM TIGR01845; multidrug efflux outer membrane protein EefC complement(1855128..1856501) Escherichia coli SMS-3-5 6145102 YP_001743889.1 CDS eefB NC_010498.1 1856505 1859612 R identified by similarity to GB:CAD48862.1; match to protein family HMM PF00873; match to protein family HMM TIGR00915; multidrug efflux transport protein EefB complement(1856505..1859612) Escherichia coli SMS-3-5 6146082 YP_001743890.1 CDS eefA NC_010498.1 1859612 1860733 R identified by similarity to GB:CAD48861.1; match to protein family HMM PF00529; match to protein family HMM TIGR01730; multidrug efflux transport protein EefA complement(1859612..1860733) Escherichia coli SMS-3-5 6143081 YP_001743891.1 CDS eefR NC_010498.1 1860882 1861448 R identified by match to protein family HMM PF00440; transcriptional regulator EefR complement(1860882..1861448) Escherichia coli SMS-3-5 6147334 YP_001743892.1 CDS EcSMS35_1838 NC_010498.1 1861624 1861764 R identified by Glimmer3; putative; hypothetical protein complement(1861624..1861764) Escherichia coli SMS-3-5 6146177 YP_001743893.1 CDS fabI NC_010498.1 1861926 1862714 D Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1861926..1862714 Escherichia coli SMS-3-5 6143250 YP_001743894.1 CDS EcSMS35_1840 NC_010498.1 1862859 1863986 D hypothetical protein 1862859..1863986 Escherichia coli SMS-3-5 6145131 YP_001743895.1 CDS rnb NC_010498.1 1864054 1865988 D Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1864054..1865988 Escherichia coli SMS-3-5 6147184 YP_001743896.1 CDS EcSMS35_1842 NC_010498.1 1866223 1868208 D c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1866223..1868208 Escherichia coli SMS-3-5 6145922 YP_001743897.1 CDS EcSMS35_1843 NC_010498.1 1868356 1868529 D hypothetical protein 1868356..1868529 Escherichia coli SMS-3-5 6145259 YP_001743898.1 CDS EcSMS35_1844 NC_010498.1 1868619 1869368 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator 1868619..1869368 Escherichia coli SMS-3-5 6144883 YP_001743899.1 CDS EcSMS35_1845 NC_010498.1 1869637 1869855 D lipoprotein 1869637..1869855 Escherichia coli SMS-3-5 6143171 YP_001743900.1 CDS EcSMS35_1846 NC_010498.1 1869981 1870310 R involved in start site selection during the initiation of translation; translation initiation factor Sui1 complement(1869981..1870310) Escherichia coli SMS-3-5 6145698 YP_001743901.1 CDS pyrF NC_010498.1 1870307 1871044 R type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase complement(1870307..1871044) Escherichia coli SMS-3-5 6145163 YP_001743902.1 CDS EcSMS35_1848 NC_010498.1 1871060 1871212 D identified by Glimmer3; putative; hypothetical protein 1871060..1871212 Escherichia coli SMS-3-5 6144328 YP_001743903.1 CDS EcSMS35_1849 NC_010498.1 1871236 1872405 R identified by match to protein family HMM PF07719; tetratricopeptide repeat protein complement(1871236..1872405) Escherichia coli SMS-3-5 6143885 YP_001743904.1 CDS EcSMS35_1850 NC_010498.1 1872412 1872720 R identified by match to protein family HMM PF06305; hypothetical protein complement(1872412..1872720) Escherichia coli SMS-3-5 6142968 YP_001743905.1 CDS pgpB NC_010498.1 1872869 1873633 R identified by match to protein family HMM PF01569; phosphatidylglycerophosphatase B complement(1872869..1873633) Escherichia coli SMS-3-5 6144682 YP_001743906.1 CDS ribA NC_010498.1 1873803 1874393 D catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1873803..1874393 Escherichia coli SMS-3-5 6146556 YP_001743907.1 CDS acnA NC_010498.1 1874457 1877132 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(1874457..1877132) Escherichia coli SMS-3-5 6142676 YP_001743908.1 CDS EcSMS35_1854 NC_010498.1 1877452 1877619 R hypothetical protein complement(1877452..1877619) Escherichia coli SMS-3-5 6145184 YP_001743909.1 CDS EcSMS35_1855 NC_010498.1 1877622 1877750 R hypothetical protein complement(1877622..1877750) Escherichia coli SMS-3-5 6145307 YP_001743910.1 CDS cysB NC_010498.1 1878081 1879055 R LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB complement(1878081..1879055) Escherichia coli SMS-3-5 6144449 YP_001743911.1 CDS topA NC_010498.1 1879264 1881861 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1879264..1881861) Escherichia coli SMS-3-5 6143780 YP_001743912.1 CDS EcSMS35_1858 NC_010498.1 1882241 1882492 D hypothetical protein 1882241..1882492 Escherichia coli SMS-3-5 6146795 YP_001743913.1 CDS sohB NC_010498.1 1882528 1883577 R SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease complement(1882528..1883577) Escherichia coli SMS-3-5 6146121 YP_001743914.1 CDS EcSMS35_1860 NC_010498.1 1883797 1884555 D identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase 1883797..1884555 Escherichia coli SMS-3-5 6146680 YP_001743915.1 CDS btuR NC_010498.1 1884552 1885142 D catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1884552..1885142 Escherichia coli SMS-3-5 6145999 YP_001743916.1 CDS EcSMS35_1862 NC_010498.1 1885195 1885503 R identified by Glimmer3; putative; hypothetical protein complement(1885195..1885503) Escherichia coli SMS-3-5 6145141 YP_001743917.1 CDS EcSMS35_1863 NC_010498.1 1885514 1886515 R putative lipoprotein complement(1885514..1886515) Escherichia coli SMS-3-5 6144729 YP_001743918.1 CDS rluB NC_010498.1 1886685 1887560 R catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B complement(1886685..1887560) Escherichia coli SMS-3-5 6143814 YP_001743919.1 CDS EcSMS35_1865 NC_010498.1 1887771 1889666 R hypothetical protein complement(1887771..1889666) Escherichia coli SMS-3-5 6146650 YP_001743920.1 CDS EcSMS35_1866 NC_010498.1 1889694 1890350 R identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; hypothetical protein complement(1889694..1890350) Escherichia coli SMS-3-5 6146178 YP_001743921.1 CDS EcSMS35_1867 NC_010498.1 1890311 1891192 R identified by match to protein family HMM PF02811; putative phosphoesterase complement(1890311..1891192) Escherichia coli SMS-3-5 6146003 YP_001743922.1 CDS trpE NC_010498.1 1891466 1893028 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1891466..1893028 Escherichia coli SMS-3-5 6145204 YP_001743923.1 CDS trpD NC_010498.1 1893028 1894623 D bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1893028..1894623 Escherichia coli SMS-3-5 6144331 YP_001743924.1 CDS trpC NC_010498.1 1894624 1895985 D monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1894624..1895985 Escherichia coli SMS-3-5 6143856 YP_001743925.1 CDS trpB NC_010498.1 1895997 1897190 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1895997..1897190 Escherichia coli SMS-3-5 6143055 YP_001743926.1 CDS trpA NC_010498.1 1897190 1897996 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1897190..1897996 Escherichia coli SMS-3-5 6142697 YP_001743927.1 CDS EcSMS35_1873 NC_010498.1 1898377 1898556 D hypothetical protein 1898377..1898556 Escherichia coli SMS-3-5 6146992 YP_001743928.1 CDS yciF NC_010498.1 1898621 1899142 D identified by match to protein family HMM PF05974; YciF protein 1898621..1899142 Escherichia coli SMS-3-5 6145968 YP_001743929.1 CDS EcSMS35_1875 NC_010498.1 1899415 1899693 D identified by match to protein family HMM PF05974; hypothetical protein 1899415..1899693 Escherichia coli SMS-3-5 6145164 YP_001743930.1 CDS ompW NC_010498.1 1899753 1900391 R receptor for colicin S4; outer membrane protein W complement(1899753..1900391) Escherichia coli SMS-3-5 6145746 YP_001743931.1 CDS EcSMS35_1877 NC_010498.1 1900746 1901489 D identified by match to protein family HMM PF06790; hypothetical protein 1900746..1901489 Escherichia coli SMS-3-5 6146548 YP_001743932.1 CDS ispZ NC_010498.1 1901519 1902058 D Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1901519..1902058 Escherichia coli SMS-3-5 6143618 YP_001743933.1 CDS yciA NC_010498.1 1902163 1902561 D YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1902163..1902561 Escherichia coli SMS-3-5 6144373 YP_001743934.1 CDS tonB NC_010498.1 1902601 1903332 R membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB complement(1902601..1903332) Escherichia coli SMS-3-5 6145010 YP_001743935.1 CDS EcSMS35_1881 NC_010498.1 1903541 1903837 D unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1903541..1903837 Escherichia coli SMS-3-5 6145790 YP_001743936.1 CDS EcSMS35_1882 NC_010498.1 1903990 1904247 D hypothetical protein 1903990..1904247 Escherichia coli SMS-3-5 6146346 YP_001743937.1 CDS EcSMS35_1884 NC_010498.1 1904356 1906149 D identified by match to protein family HMM PF00884; sulfatase family protein 1904356..1906149 Escherichia coli SMS-3-5 6147190 YP_001743938.1 CDS EcSMS35_1883 NC_010498.1 1906146 1906745 R ylcE; identified by Glimmer3; putative; hypothetical protein complement(1906146..1906745) Escherichia coli SMS-3-5 6143116 YP_001743939.1 CDS EcSMS35_1885 NC_010498.1 1906891 1907157 R identified by Glimmer3; putative; hypothetical protein complement(1906891..1907157) Escherichia coli SMS-3-5 6146652 YP_001743940.1 CDS EcSMS35_1886 NC_010498.1 1907391 1907738 D identified by similarity to GB:ABG71805.1; IS3 family transposase 1907391..1907738 Escherichia coli SMS-3-5 6144232 YP_001743941.1 CDS EcSMS35_1887 NC_010498.1 1907782 1908192 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1907782..1908192 Escherichia coli SMS-3-5 6144912 YP_001743942.1 CDS EcSMS35_1888 NC_010498.1 1908150 1909055 D identified by match to protein family HMM PF00665; IS2 transposase orfB 1908150..1909055 Escherichia coli SMS-3-5 6145253 YP_001743943.1 CDS EcSMS35_1889 NC_010498.1 1909030 1909569 D identified by match to protein family HMM PF00665; IS911 transposase orfB 1909030..1909569 Escherichia coli SMS-3-5 6145119 YP_001743944.1 CDS kch NC_010498.1 1910255 1911463 D identified by match to protein family HMM PF02254; match to protein family HMM PF07885; voltage-gated potassium channel 1910255..1911463 Escherichia coli SMS-3-5 6146258 YP_001743945.1 CDS cls NC_010498.1 1911834 1913294 D catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1911834..1913294 Escherichia coli SMS-3-5 6146798 YP_001743946.1 CDS EcSMS35_1892 NC_010498.1 1913329 1913658 D highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1913329..1913658 Escherichia coli SMS-3-5 6142664 YP_001743947.1 CDS oppF NC_010498.1 1913711 1914715 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide ABC transporter ATP-binding protein OppF complement(1913711..1914715) Escherichia coli SMS-3-5 6143224 YP_001743948.1 CDS oppD NC_010498.1 1914712 1915725 R identified by similarity to SP:P76027; match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transporter ATP-binding component complement(1914712..1915725) Escherichia coli SMS-3-5 6144189 YP_001743949.1 CDS oppC NC_010498.1 1915737 1916642 R identified by similarity to SP:P08006; match to protein family HMM PF00528; oligopeptide ABC transporter permease OppC complement(1915737..1916642) Escherichia coli SMS-3-5 6143595 YP_001743950.1 CDS oppB NC_010498.1 1916660 1917580 R identified by match to protein family HMM PF00528; oligopeptide transporter permease complement(1916660..1917580) Escherichia coli SMS-3-5 6142758 YP_001743951.1 CDS oppA NC_010498.1 1917666 1919342 R identified by match to protein family HMM PF00496; oligopeptide ABC transporter periplasmic oligopeptide-binding protein complement(1917666..1919342) Escherichia coli SMS-3-5 6145903 YP_001743952.1 CDS EcSMS35_1899 NC_010498.1 1919581 1919877 D identified by Glimmer3; putative; hypothetical protein 1919581..1919877 Escherichia coli SMS-3-5 6145488 YP_001743953.1 CDS EcSMS35_1898 NC_010498.1 1919853 1920008 R identified by Glimmer3; putative; hypothetical protein complement(1919853..1920008) Escherichia coli SMS-3-5 6146542 YP_001743954.1 CDS EcSMS35_1900 NC_010498.1 1920035 1920682 R identified by match to protein family HMM PF01914; match to protein family HMM TIGR00427; hypothetical protein complement(1920035..1920682) Escherichia coli SMS-3-5 6146980 YP_001743955.1 CDS adhE NC_010498.1 1921159 1923834 D identified by match to protein family HMM PF00171; match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1921159..1923834 Escherichia coli SMS-3-5 6146148 YP_001743956.1 CDS tdk NC_010498.1 1924137 1924754 R catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase complement(1924137..1924754) Escherichia coli SMS-3-5 6143242 YP_001743957.1 CDS EcSMS35_1903 NC_010498.1 1925138 1925266 D identified by Glimmer3; putative; hypothetical protein 1925138..1925266 Escherichia coli SMS-3-5 6144805 YP_001743958.1 CDS EcSMS35_1904 NC_010498.1 1925358 1925771 D identified by match to protein family HMM PF00816; global DNA-binding transcriptional dual regulator H-NS 1925358..1925771 Escherichia coli SMS-3-5 6144477 YP_001743959.1 CDS galU NC_010498.1 1925916 1926824 R together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU complement(1925916..1926824) Escherichia coli SMS-3-5 6145308 YP_001743960.1 CDS EcSMS35_1906 NC_010498.1 1927026 1928039 R identified by match to protein family HMM PF00072; response regulator of RpoS complement(1927026..1928039) Escherichia coli SMS-3-5 6145668 YP_001743961.1 CDS EcSMS35_1907 NC_010498.1 1928131 1929075 R identified by match to protein family HMM PF01734; hypothetical protein complement(1928131..1929075) Escherichia coli SMS-3-5 6146046 YP_001743962.1 CDS EcSMS35_1908 NC_010498.1 1929128 1929607 D identified by match to protein family HMM PF02810; hypothetical protein 1929128..1929607 Escherichia coli SMS-3-5 6144085 YP_001743963.1 CDS purU NC_010498.1 1929657 1930499 D produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1929657..1930499 Escherichia coli SMS-3-5 6147441 YP_001743964.1 CDS narI NC_010498.1 1931224 1931901 R identified by similarity to SP:P11350; match to protein family HMM PF02665; match to protein family HMM TIGR00351; respiratory nitrate reductase 1, gamma subunit complement(1931224..1931901) Escherichia coli SMS-3-5 6143652 YP_001743965.1 CDS narJ NC_010498.1 1931901 1932611 R identified by similarity to SP:P0AF26; match to protein family HMM PF02613; match to protein family HMM TIGR00684; nitrate reductase molybdenum cofactor assembly chaperone 1 complement(1931901..1932611) Escherichia coli SMS-3-5 6143178 YP_001743966.1 CDS narH NC_010498.1 1932608 1934146 R identified by similarity to SP:P11349; match to protein family HMM PF00037; match to protein family HMM TIGR01660; nitrate reductase 1, beta subunit complement(1932608..1934146) Escherichia coli SMS-3-5 6146534 YP_001743967.1 CDS narG NC_010498.1 1934143 1937886 R identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; nitrate reductase 1, alpha subunit complement(1934143..1937886) Escherichia coli SMS-3-5 6146784 YP_001743968.1 CDS narK NC_010498.1 1938280 1939671 R identified by similarity to SP:P10903; match to protein family HMM PF07690; match to protein family HMM TIGR00886; nitrite extrusion protein 1 complement(1938280..1939671) Escherichia coli SMS-3-5 6145199 YP_001743969.1 CDS EcSMS35_1917 NC_010498.1 1939766 1939984 R identified by Glimmer3; putative; hypothetical protein complement(1939766..1939984) Escherichia coli SMS-3-5 6146877 YP_001743970.1 CDS narX NC_010498.1 1940010 1941806 D identified by similarity to SP:P0AFA2; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730; nitrate/nitrite sensor protein NarX 1940010..1941806 Escherichia coli SMS-3-5 6145880 YP_001743971.1 CDS narL NC_010498.1 1941799 1942449 D two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1941799..1942449 Escherichia coli SMS-3-5 6146386 YP_001743972.1 CDS EcSMS35_1920 NC_010498.1 1942450 1943844 R ychO; hypothetical protein complement(1942450..1943844) Escherichia coli SMS-3-5 6146894 YP_001743973.1 CDS EcSMS35_1921 NC_010498.1 1944029 1944382 D identified by match to protein family HMM PF02635; dsrE family protein 1944029..1944382 Escherichia coli SMS-3-5 6147424 YP_001743974.1 CDS EcSMS35_1922 NC_010498.1 1944426 1945121 R identified by match to protein family HMM PF04752; chaC protein complement(1944426..1945121) Escherichia coli SMS-3-5 6143479 YP_001743975.1 CDS chaB NC_010498.1 1945279 1945509 R in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator complement(1945279..1945509) Escherichia coli SMS-3-5 6146310 YP_001743976.1 CDS EcSMS35_1924 NC_010498.1 1945779 1946879 D identified by match to protein family HMM PF01699; match to protein family HMM TIGR00846; calcium/sodium:proton antiporter 1945779..1946879 Escherichia coli SMS-3-5 6146978 YP_001743977.1 CDS EcSMS35_1925 NC_010498.1 1947258 1947392 D hypothetical protein 1947258..1947392 Escherichia coli SMS-3-5 6147359 YP_001743978.1 CDS EcSMS35_1926 NC_010498.1 1947793 1947927 D hypothetical protein 1947793..1947927 Escherichia coli SMS-3-5 6143097 YP_001743979.1 CDS kdsA NC_010498.1 1948076 1948930 R catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase complement(1948076..1948930) Escherichia coli SMS-3-5 6144212 YP_001743980.1 CDS sirB1 NC_010498.1 1948966 1949775 R putative transcriptional regulator complement(1948966..1949775) Escherichia coli SMS-3-5 6143600 YP_001743981.1 CDS EcSMS35_1929 NC_010498.1 1949779 1950171 R identified by match to protein family HMM PF04247; putative transcriptional regulator complement(1949779..1950171) Escherichia coli SMS-3-5 6144348 YP_001743982.1 CDS hemK NC_010498.1 1950168 1951001 R HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(1950168..1951001) Escherichia coli SMS-3-5 6144851 YP_001743983.1 CDS prfA NC_010498.1 1951001 1952083 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(1951001..1952083) Escherichia coli SMS-3-5 6147402 YP_001743984.1 CDS hemA NC_010498.1 1952125 1953381 R catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase complement(1952125..1953381) Escherichia coli SMS-3-5 6146836 YP_001743985.1 CDS lolB NC_010498.1 1953595 1954218 D Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1953595..1954218 Escherichia coli SMS-3-5 6144766 YP_001743986.1 CDS ipk NC_010498.1 1954218 1955069 D An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1954218..1955069 Escherichia coli SMS-3-5 6144276 YP_001743987.1 CDS prs NC_010498.1 1955154 1956167 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1955154..1956167 Escherichia coli SMS-3-5 6145235 YP_001743988.1 CDS ychM NC_010498.1 1956292 1957971 D putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM 1956292..1957971 Escherichia coli SMS-3-5 6144803 YP_001743989.1 CDS EcSMS35_1937 NC_010498.1 1958026 1958304 R YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein complement(1958026..1958304) Escherichia coli SMS-3-5 6143806 YP_001743990.1 CDS pth NC_010498.1 1958582 1959166 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1958582..1959166 Escherichia coli SMS-3-5 6143166 YP_001743991.1 CDS engD NC_010498.1 1959283 1960374 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1959283..1960374 Escherichia coli SMS-3-5 6145658 YP_001743992.1 CDS dhaR NC_010498.1 1960779 1962698 R Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR complement(1960779..1962698) Escherichia coli SMS-3-5 6145166 YP_001743993.1 CDS dhaK NC_010498.1 1962926 1963996 D with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1962926..1963996 Escherichia coli SMS-3-5 6146488 YP_001743994.1 CDS dhaL NC_010498.1 1964007 1964639 D with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1964007..1964639 Escherichia coli SMS-3-5 6145954 YP_001743995.1 CDS dhaM NC_010498.1 1964650 1966068 D phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M 1964650..1966068 Escherichia coli SMS-3-5 6146765 YP_001743996.1 CDS EcSMS35_1944 NC_010498.1 1966095 1966208 D identified by Glimmer3; putative; hypothetical protein 1966095..1966208 Escherichia coli SMS-3-5 6146245 YP_001743997.1 CDS EcSMS35_1945 NC_010498.1 1966227 1966400 R hypothetical protein complement(1966227..1966400) Escherichia coli SMS-3-5 6143223 YP_001743998.1 CDS treA NC_010498.1 1966387 1968084 D periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1966387..1968084 Escherichia coli SMS-3-5 6142681 YP_001743999.1 CDS EcSMS35_1947 NC_010498.1 1968414 1969436 D identified by match to protein family HMM PF01497; iron(III) ABC transporter periplasmic iron(III)-binding protein 1968414..1969436 Escherichia coli SMS-3-5 6146065 YP_001744000.1 CDS EcSMS35_1948 NC_010498.1 1969436 1970416 D identified by match to protein family HMM PF00950; match to protein family HMM PF01032; iron(III) ABC transporter permease 1969436..1970416 Escherichia coli SMS-3-5 6146161 YP_001744001.1 CDS EcSMS35_1949 NC_010498.1 1970413 1971171 D identified by match to protein family HMM PF00005; iron(III) ABC transporter ATP-binding protein 1970413..1971171 Escherichia coli SMS-3-5 6144514 YP_001744002.1 CDS EcSMS35_1950 NC_010498.1 1971181 1971993 D identified by match to protein family HMM PF08242; putative methyltransferase 1971181..1971993 Escherichia coli SMS-3-5 6145181 YP_001744003.1 CDS modD NC_010498.1 1971990 1972844 D involved in molybdenum transport; molybdenum transport protein ModD 1971990..1972844 Escherichia coli SMS-3-5 6143976 YP_001744004.1 CDS EcSMS35_1952 NC_010498.1 1972870 1974840 D identified by match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 1972870..1974840 Escherichia coli SMS-3-5 6144049 YP_001744005.1 CDS EcSMS35_1953 NC_010498.1 1974890 1975144 R identified by match to protein family HMM PF04226; transglycosylase-associated protein complement(1974890..1975144) Escherichia coli SMS-3-5 6147130 YP_001744006.1 CDS EcSMS35_1954 NC_010498.1 1975345 1976079 D identified by match to protein family HMM PF07238; match to protein family HMM PF07317; putative type IV pilus assembly protein PilZ 1975345..1976079 Escherichia coli SMS-3-5 6142884 YP_001744007.1 CDS mltE NC_010498.1 1976081 1976692 R identified by match to protein family HMM PF01464; membrane-bound lytic murein transglycosylase E complement(1976081..1976692) Escherichia coli SMS-3-5 6146599 YP_001744008.1 CDS ldcA NC_010498.1 1976792 1977706 D catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1976792..1977706 Escherichia coli SMS-3-5 6147279 YP_001744009.1 CDS cvrA NC_010498.1 1977801 1979537 D the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1977801..1979537 Escherichia coli SMS-3-5 6143202 YP_001744010.1 CDS EcSMS35_1958 NC_010498.1 1980286 1981593 D identified by similarity to GB:ABB61379.1; hypothetical protein 1980286..1981593 Escherichia coli SMS-3-5 6142645 YP_001744011.1 CDS dadX NC_010498.1 1981763 1982833 R catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase complement(1981763..1982833) Escherichia coli SMS-3-5 6146230 YP_001744012.1 CDS dadA NC_010498.1 1982843 1984147 R catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit complement(1982843..1984147) Escherichia coli SMS-3-5 6145986 YP_001744013.1 CDS EcSMS35_1961 NC_010498.1 1984471 1986003 D identified by match to protein family HMM PF04293; SpoVR family protein 1984471..1986003 Escherichia coli SMS-3-5 6145482 YP_001744014.1 CDS fadR NC_010498.1 1986055 1986774 R Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator complement(1986055..1986774) Escherichia coli SMS-3-5 6146017 YP_001744015.1 CDS nhaB NC_010498.1 1986997 1988538 D involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1986997..1988538 Escherichia coli SMS-3-5 6145508 YP_001744016.1 CDS dsbB NC_010498.1 1988684 1989214 D disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1988684..1989214 Escherichia coli SMS-3-5 6144639 YP_001744017.1 CDS umuC NC_010498.1 1989260 1990528 R binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC complement(1989260..1990528) Escherichia coli SMS-3-5 6144123 YP_001744018.1 CDS umuD NC_010498.1 1990528 1990947 R binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD complement(1990528..1990947) Escherichia coli SMS-3-5 6147341 YP_001744019.1 CDS hlyE NC_010498.1 1991319 1992230 D Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E 1991319..1992230 Escherichia coli SMS-3-5 6143071 YP_001744020.1 CDS EcSMS35_1968 NC_010498.1 1992437 1992898 R identified by match to protein family HMM PF03692; hypothetical protein complement(1992437..1992898) Escherichia coli SMS-3-5 6146308 YP_001744021.1 CDS EcSMS35_1969 NC_010498.1 1992975 1993634 R identified by match to protein family HMM PF01557; hypothetical protein complement(1992975..1993634) Escherichia coli SMS-3-5 6147024 YP_001744022.1 CDS EcSMS35_1970 NC_010498.1 1993706 1993999 R identified by match to protein family HMM PF05166; hypothetical protein complement(1993706..1993999) Escherichia coli SMS-3-5 6147275 YP_001744023.1 CDS EcSMS35_1971 NC_010498.1 1994242 1994643 D identified by match to protein family HMM PF04151; pre-peptidase C-terminal domain-containing protein 1994242..1994643 Escherichia coli SMS-3-5 6145238 YP_001744024.1 CDS EcSMS35_1972 NC_010498.1 1994746 1995114 R identified by match to protein family HMM PF05666; putative fels-1 prophage protein complement(1994746..1995114) Escherichia coli SMS-3-5 6144985 YP_001744025.1 CDS minC NC_010498.1 1995634 1996329 D blocks the formation of polar Z-ring septums; septum formation inhibitor 1995634..1996329 Escherichia coli SMS-3-5 6145637 YP_001744026.1 CDS minD NC_010498.1 1996353 1997165 D ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1996353..1997165 Escherichia coli SMS-3-5 6144557 YP_001744027.1 CDS minE NC_010498.1 1997169 1997435 D works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1997169..1997435 Escherichia coli SMS-3-5 6147388 YP_001744028.1 CDS EcSMS35_1976 NC_010498.1 1997802 1998128 R identified by Glimmer3; putative; hypothetical protein complement(1997802..1998128) Escherichia coli SMS-3-5 6147123 YP_001744029.1 CDS EcSMS35_1977 NC_010498.1 1998546 1998719 D identified by Glimmer3; putative; hypothetical protein 1998546..1998719 Escherichia coli SMS-3-5 6145355 YP_001744030.1 CDS EcSMS35_1978 NC_010498.1 1998721 1999065 D hypothetical protein 1998721..1999065 Escherichia coli SMS-3-5 6146063 YP_001744031.1 CDS EcSMS35_1979 NC_010498.1 1999075 1999404 D identified by Glimmer3; putative; hypothetical protein 1999075..1999404 Escherichia coli SMS-3-5 6143736 YP_001744032.1 CDS EcSMS35_1980 NC_010498.1 1999462 2001783 R identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; autotransporter (AT) family porin complement(1999462..2001783) Escherichia coli SMS-3-5 6144394 YP_001744033.1 CDS EcSMS35_1981 NC_010498.1 2002274 2002393 R identified by Glimmer3; putative; hypothetical protein complement(2002274..2002393) Escherichia coli SMS-3-5 6147534 YP_001744034.1 CDS EcSMS35_1982 NC_010498.1 2002510 2002728 R hypothetical protein complement(2002510..2002728) Escherichia coli SMS-3-5 6146588 YP_001744035.1 CDS EcSMS35_1983 NC_010498.1 2002860 2004320 R identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein complement(2002860..2004320) Escherichia coli SMS-3-5 6143381 YP_001744036.1 CDS EcSMS35_1984 NC_010498.1 2004715 2004891 R hypothetical protein complement(2004715..2004891) Escherichia coli SMS-3-5 6142670 YP_001744037.1 CDS EcSMS35_1985 NC_010498.1 2005076 2005342 R hypothetical protein complement(2005076..2005342) Escherichia coli SMS-3-5 6144513 YP_001744038.1 CDS EcSMS35_1986 NC_010498.1 2006236 2007447 D identified by match to protein family HMM PF00563; match to protein family HMM PF04940; BLUF/cyclic diguanylate phosphodiesterase domain-containing protein 2006236..2007447 Escherichia coli SMS-3-5 6143267 YP_001744039.1 CDS mlrA NC_010498.1 2007652 2008383 D identified by match to protein family HMM PF00376; transcriptional regulator mlrA 2007652..2008383 Escherichia coli SMS-3-5 6144680 YP_001744040.1 CDS EcSMS35_1988 NC_010498.1 2008604 2009008 D identified by match to protein family HMM PF07166; hypothetical protein 2008604..2009008 Escherichia coli SMS-3-5 6144139 YP_001744041.1 CDS icd NC_010498.1 2010137 2011387 R Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase complement(2010137..2011387) Escherichia coli SMS-3-5 6146030 YP_001744042.1 CDS rluE NC_010498.1 2011589 2012212 D catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 2011589..2012212 Escherichia coli SMS-3-5 6144116 YP_001744043.1 CDS EcSMS35_1991 NC_010498.1 2012222 2012683 D identified by match to protein family HMM PF00293; NUDIX family hydrolase 2012222..2012683 Escherichia coli SMS-3-5 6145971 YP_001744044.1 CDS mnmA NC_010498.1 2012737 2013843 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2012737..2013843 Escherichia coli SMS-3-5 6145513 YP_001744045.1 CDS EcSMS35_1993 NC_010498.1 2013879 2014520 D HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 2013879..2014520 Escherichia coli SMS-3-5 6146727 YP_001744046.1 CDS purB NC_010498.1 2014524 2015894 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2014524..2015894 Escherichia coli SMS-3-5 6146250 YP_001744047.1 CDS phoP NC_010498.1 2016063 2016734 D response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 2016063..2016734 Escherichia coli SMS-3-5 6146678 YP_001744048.1 CDS phoQ NC_010498.1 2016734 2018194 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF08918; sensor protein PhoQ 2016734..2018194 Escherichia coli SMS-3-5 6145416 YP_001744049.1 CDS EcSMS35_1997 NC_010498.1 2018270 2019391 D identified by match to protein family HMM PF08007; cupin family protein 2018270..2019391 Escherichia coli SMS-3-5 6146077 YP_001744050.1 CDS pepT NC_010498.1 2019440 2020708 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(2019440..2020708) Escherichia coli SMS-3-5 6144694 YP_001744051.1 CDS EcSMS35_1999 NC_010498.1 2020686 2020937 D identified by Glimmer3; putative; hypothetical protein 2020686..2020937 Escherichia coli SMS-3-5 6142851 YP_001744052.1 CDS potA NC_010498.1 2020916 2022052 D functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 2020916..2022052 Escherichia coli SMS-3-5 6142611 YP_001744053.1 CDS potB NC_010498.1 2022036 2022893 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 2022036..2022893 Escherichia coli SMS-3-5 6146436 YP_001744054.1 CDS potC NC_010498.1 2022890 2023684 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 2022890..2023684 Escherichia coli SMS-3-5 6145651 YP_001744055.1 CDS potD NC_010498.1 2023681 2024727 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 2023681..2024727 Escherichia coli SMS-3-5 6144835 YP_001744056.1 CDS EcSMS35_2004 NC_010498.1 2024785 2025246 D hypothetical protein 2024785..2025246 Escherichia coli SMS-3-5 6144616 YP_001744057.1 CDS EcSMS35_2005 NC_010498.1 2025243 2026031 D hypothetical protein 2025243..2026031 Escherichia coli SMS-3-5 6147425 YP_001744058.1 CDS npdA NC_010498.1 2026169 2026990 R Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase complement(2026169..2026990) Escherichia coli SMS-3-5 6143561 YP_001744059.1 CDS nagK NC_010498.1 2027006 2027917 R catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase complement(2027006..2027917) Escherichia coli SMS-3-5 6142817 YP_001744060.1 CDS lolE NC_010498.1 2027946 2029190 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE complement(2027946..2029190) Escherichia coli SMS-3-5 6146219 YP_001744061.1 CDS lolD NC_010498.1 2029190 2029891 R outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit complement(2029190..2029891) Escherichia coli SMS-3-5 6146579 YP_001744062.1 CDS lolC NC_010498.1 2029884 2031083 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC complement(2029884..2031083) Escherichia coli SMS-3-5 6144115 YP_001744063.1 CDS EcSMS35_2011 NC_010498.1 2031344 2032417 D identified by match to protein family HMM PF01757; putative acyltransferase 2031344..2032417 Escherichia coli SMS-3-5 6143108 YP_001744064.1 CDS mfd NC_010498.1 2032545 2035991 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 2032545..2035991 Escherichia coli SMS-3-5 6142779 YP_001744065.1 CDS EcSMS35_2013 NC_010498.1 2036139 2037098 D identified by match to protein family HMM PF01476; match to protein family HMM PF03734; LysM/ErfK/YbiS/YcfS/YnhG family protein 2036139..2037098 Escherichia coli SMS-3-5 6147057 YP_001744066.1 CDS EcSMS35_2014 NC_010498.1 2037180 2037437 R identified by match to protein family HMM PF07338; hypothetical protein complement(2037180..2037437) Escherichia coli SMS-3-5 6145762 YP_001744067.1 CDS EcSMS35_2015 NC_010498.1 2037678 2038310 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 2037678..2038310 Escherichia coli SMS-3-5 6145106 YP_001744068.1 CDS EcSMS35_2016 NC_010498.1 2038372 2038911 R identified by match to protein family HMM PF05433; hypothetical protein complement(2038372..2038911) Escherichia coli SMS-3-5 6145170 YP_001744069.1 CDS ndh NC_010498.1 2039138 2040442 R identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF07992; NADH dehydrogenase complement(2039138..2040442) Escherichia coli SMS-3-5 6143761 YP_001744070.1 CDS EcSMS35_2018 NC_010498.1 2040842 2041384 R identified by match to protein family HMM PF05728; hypothetical protein complement(2040842..2041384) Escherichia coli SMS-3-5 6142939 YP_001744071.1 CDS nagZ NC_010498.1 2041407 2042432 R hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase complement(2041407..2042432) Escherichia coli SMS-3-5 6143482 YP_001744072.1 CDS thiK NC_010498.1 2042443 2043267 R catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase complement(2042443..2043267) Escherichia coli SMS-3-5 6142954 YP_001744073.1 CDS EcSMS35_2021 NC_010498.1 2043248 2043889 R identified by match to protein family HMM TIGR02722; putative lipoprotein complement(2043248..2043889) Escherichia coli SMS-3-5 6143488 YP_001744074.1 CDS EcSMS35_2022 NC_010498.1 2043903 2044256 R identified by match to protein family HMM PF07233; putative lipoprotein complement(2043903..2044256) Escherichia coli SMS-3-5 6146520 YP_001744075.1 CDS hinT NC_010498.1 2044283 2044642 R identified by match to protein family HMM PF01230; purine nucleoside phosphoramidase complement(2044283..2044642) Escherichia coli SMS-3-5 6147076 YP_001744076.1 CDS EcSMS35_2024 NC_010498.1 2044773 2044943 D hypothetical protein 2044773..2044943 Escherichia coli SMS-3-5 6145186 YP_001744077.1 CDS fhuE NC_010498.1 2044976 2047165 D identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; ferric-rhodotorulic acid outer membrane transporter 2044976..2047165 Escherichia coli SMS-3-5 6145621 YP_001744078.1 CDS ptsG NC_010498.1 2047225 2048658 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC complement(2047225..2048658) Escherichia coli SMS-3-5 6147185 YP_001744079.1 CDS EcSMS35_2027 NC_010498.1 2048953 2049750 R identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; putative metallodependent hydrolase complement(2048953..2049750) Escherichia coli SMS-3-5 6145435 YP_001744080.1 CDS holB NC_010498.1 2049761 2050765 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(2049761..2050765) Escherichia coli SMS-3-5 6145190 YP_001744081.1 CDS tmk NC_010498.1 2050762 2051403 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(2050762..2051403) Escherichia coli SMS-3-5 6145683 YP_001744082.1 CDS EcSMS35_2030 NC_010498.1 2051393 2052415 R identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; hypothetical protein complement(2051393..2052415) Escherichia coli SMS-3-5 6143892 YP_001744083.1 CDS pabC NC_010498.1 2052418 2053227 R catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase complement(2052418..2053227) Escherichia coli SMS-3-5 6144366 YP_001744084.1 CDS fabF NC_010498.1 2053347 2054588 R FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II complement(2053347..2054588) Escherichia coli SMS-3-5 6142924 YP_001744085.1 CDS acpP NC_010498.1 2054676 2054912 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(2054676..2054912) Escherichia coli SMS-3-5 6143480 YP_001744086.1 CDS fabG NC_010498.1 2055123 2055857 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase complement(2055123..2055857) Escherichia coli SMS-3-5 6145465 YP_001744087.1 CDS fabD NC_010498.1 2055870 2056799 R identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase complement(2055870..2056799) Escherichia coli SMS-3-5 6145963 YP_001744088.1 CDS fabH NC_010498.1 2056815 2057768 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III complement(2056815..2057768) Escherichia coli SMS-3-5 6142630 YP_001744089.1 CDS plsX NC_010498.1 2057836 2058906 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX complement(2057836..2058906) Escherichia coli SMS-3-5 6144324 YP_001744090.1 CDS rpmF NC_010498.1 2058987 2059160 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(2058987..2059160) Escherichia coli SMS-3-5 6144151 YP_001744091.1 CDS EcSMS35_2039 NC_010498.1 2059212 2059733 R identified by match to protein family HMM PF02620; hypothetical protein complement(2059212..2059733) Escherichia coli SMS-3-5 6145552 YP_001744092.1 CDS maf2 NC_010498.1 2059893 2060516 D Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 2059893..2060516 Escherichia coli SMS-3-5 6147263 YP_001744093.1 CDS rluC NC_010498.1 2060627 2061586 R catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C complement(2060627..2061586) Escherichia coli SMS-3-5 6146596 YP_001744094.1 CDS rne NC_010498.1 2062159 2065332 D bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 2062159..2065332 Escherichia coli SMS-3-5 6143391 YP_001744095.1 CDS EcSMS35_2043 NC_010498.1 2065466 2065759 D identified by match to protein family HMM PF08681; hypothetical protein 2065466..2065759 Escherichia coli SMS-3-5 6142714 YP_001744096.1 CDS EcSMS35_2044 NC_010498.1 2065756 2066250 D identified by match to protein family HMM PF00583; acetyltransferase 2065756..2066250 Escherichia coli SMS-3-5 6143212 YP_001744097.1 CDS flgL NC_010498.1 2066345 2067298 R with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL complement(2066345..2067298) Escherichia coli SMS-3-5 6142693 YP_001744098.1 CDS flgK NC_010498.1 2067310 2068953 R with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK complement(2067310..2068953) Escherichia coli SMS-3-5 6144648 YP_001744099.1 CDS flgJ NC_010498.1 2069019 2069960 R Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ complement(2069019..2069960) Escherichia coli SMS-3-5 6142949 YP_001744100.1 CDS flgI NC_010498.1 2069960 2071057 R part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein complement(2069960..2071057) Escherichia coli SMS-3-5 6143125 YP_001744101.1 CDS flgH NC_010498.1 2071069 2071767 R part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein complement(2071069..2071767) Escherichia coli SMS-3-5 6146171 YP_001744102.1 CDS flgG NC_010498.1 2071820 2072602 R makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG complement(2071820..2072602) Escherichia coli SMS-3-5 6145914 YP_001744103.1 CDS flgF NC_010498.1 2072739 2073494 R FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF complement(2072739..2073494) Escherichia coli SMS-3-5 6144052 YP_001744104.1 CDS flgE NC_010498.1 2073514 2074719 R the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE complement(2073514..2074719) Escherichia coli SMS-3-5 6144330 YP_001744105.1 CDS flgD NC_010498.1 2074744 2075439 R acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein complement(2074744..2075439) Escherichia coli SMS-3-5 6142626 YP_001744106.1 CDS flgC NC_010498.1 2075451 2075855 R with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC complement(2075451..2075855) Escherichia coli SMS-3-5 6146234 YP_001744107.1 CDS flgB NC_010498.1 2075859 2076275 R with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB complement(2075859..2076275) Escherichia coli SMS-3-5 6146766 YP_001744108.1 CDS EcSMS35_2056 NC_010498.1 2076292 2076462 R identified by Glimmer3; putative; hypothetical protein complement(2076292..2076462) Escherichia coli SMS-3-5 6147490 YP_001744109.1 CDS flgA NC_010498.1 2076431 2077090 D required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 2076431..2077090 Escherichia coli SMS-3-5 6143271 YP_001744110.1 CDS flgM NC_010498.1 2077166 2077459 D regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 2077166..2077459 Escherichia coli SMS-3-5 6146159 YP_001744111.1 CDS flgN NC_010498.1 2077464 2077880 D identified by match to protein family HMM PF05130; flagella synthesis protein FlgN 2077464..2077880 Escherichia coli SMS-3-5 6146830 YP_001744112.1 CDS mviN NC_010498.1 2077920 2079455 R identified by match to protein family HMM PF03023; match to protein family HMM TIGR01695; integral membrane protein MviN complement(2077920..2079455) Escherichia coli SMS-3-5 6142791 YP_001744113.1 CDS EcSMS35_2061 NC_010498.1 2079565 2080488 R identified by match to protein family HMM PF01408; match to protein family HMM PF02894; oxidoreductase family protein complement(2079565..2080488) Escherichia coli SMS-3-5 6143354 YP_001744114.1 CDS EcSMS35_2062 NC_010498.1 2080490 2081137 R identified by match to protein family HMM PF04337; hypothetical protein complement(2080490..2081137) Escherichia coli SMS-3-5 6146595 YP_001744115.1 CDS rimJ NC_010498.1 2081148 2081732 R identified by match to protein family HMM PF00583; ribosomal-protein-S5-alanine N-acetyltransferase complement(2081148..2081732) Escherichia coli SMS-3-5 6146206 YP_001744116.1 CDS mdtH NC_010498.1 2081968 2083176 D Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 2081968..2083176 Escherichia coli SMS-3-5 6145060 YP_001744117.1 CDS grxB NC_010498.1 2083240 2083887 D cofactor involved in the reduction of disulfides; glutaredoxin 2 2083240..2083887 Escherichia coli SMS-3-5 6145532 YP_001744118.1 CDS EcSMS35_2066 NC_010498.1 2084021 2084581 D identified by match to protein family HMM PF07273; hypothetical protein 2084021..2084581 Escherichia coli SMS-3-5 6146543 YP_001744119.1 CDS pyrC NC_010498.1 2084687 2085733 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 2084687..2085733 Escherichia coli SMS-3-5 6147117 YP_001744120.1 CDS dinI NC_010498.1 2085807 2086052 D identified by match to protein family HMM PF06183; DNA damage-inducible protein I 2085807..2086052 Escherichia coli SMS-3-5 6144319 YP_001744121.1 CDS bssS NC_010498.1 2086342 2086596 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 2086342..2086596 Escherichia coli SMS-3-5 6145169 YP_001744122.1 CDS solA NC_010498.1 2086711 2087829 D catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 2086711..2087829 Escherichia coli SMS-3-5 6143871 YP_001744123.1 CDS EcSMS35_2071 NC_010498.1 2087877 2087990 D hypothetical protein 2087877..2087990 Escherichia coli SMS-3-5 6144351 YP_001744124.1 CDS EcSMS35_2072 NC_010498.1 2088115 2088261 R hypothetical protein complement(2088115..2088261) Escherichia coli SMS-3-5 6142937 YP_001744125.1 CDS EcSMS35_2073 NC_010498.1 2088176 2088817 D identified by match to protein family HMM PF01292; nickel-dependent hydrogenase b-type cytochrome subunit 2088176..2088817 Escherichia coli SMS-3-5 6143306 YP_001744126.1 CDS yceI NC_010498.1 2088821 2089396 D identified by match to protein family HMM PF04264; hypothetical protein 2088821..2089396 Escherichia coli SMS-3-5 6144107 YP_001744127.1 CDS EcSMS35_2075 NC_010498.1 2089438 2090490 R identified by match to protein family HMM PF00581; hypothetical protein complement(2089438..2090490) Escherichia coli SMS-3-5 6144621 YP_001744128.1 CDS lpxL NC_010498.1 2090715 2091635 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2090715..2091635 Escherichia coli SMS-3-5 6144969 YP_001744129.1 CDS mdtG NC_010498.1 2091807 2093033 D Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 2091807..2093033 Escherichia coli SMS-3-5 6145402 YP_001744130.1 CDS msyB NC_010498.1 2093116 2093490 D hypothetical protein 2093116..2093490 Escherichia coli SMS-3-5 6143962 YP_001744131.1 CDS EcSMS35_2079 NC_010498.1 2093491 2093718 R identified by match to protein family HMM PF07119; hypothetical protein complement(2093491..2093718) Escherichia coli SMS-3-5 6144347 YP_001744132.1 CDS mdoH NC_010498.1 2093891 2096404 R necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH complement(2093891..2096404) Escherichia coli SMS-3-5 6142742 YP_001744133.1 CDS mdoG NC_010498.1 2096427 2097980 R involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G complement(2096427..2097980) Escherichia coli SMS-3-5 6143444 YP_001744134.1 CDS EcSMS35_2082 NC_010498.1 2098033 2098164 D identified by Glimmer3; putative; hypothetical protein 2098033..2098164 Escherichia coli SMS-3-5 6146572 YP_001744135.1 CDS EcSMS35_2083 NC_010498.1 2098168 2098311 D identified by Glimmer3; putative; hypothetical protein 2098168..2098311 Escherichia coli SMS-3-5 6147140 YP_001744136.1 CDS mdoC NC_010498.1 2098356 2099513 D required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 2098356..2099513 Escherichia coli SMS-3-5 6142973 YP_001744137.1 CDS EcSMS35_2085 NC_010498.1 2099521 2100942 R identified by match to protein family HMM PF00614; phopholipase D complement(2099521..2100942) Escherichia coli SMS-3-5 6143510 YP_001744138.1 CDS EcSMS35_2086 NC_010498.1 2100944 2101477 R identified by match to protein family HMM PF01661; hypothetical protein complement(2100944..2101477) Escherichia coli SMS-3-5 6146984 YP_001744139.1 CDS EcSMS35_2087 NC_010498.1 2101572 2101727 R hypothetical protein complement(2101572..2101727) Escherichia coli SMS-3-5 6146167 YP_001744140.1 CDS csgC NC_010498.1 2102004 2102336 R involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein complement(2102004..2102336) Escherichia coli SMS-3-5 6143170 YP_001744141.1 CDS csgA NC_010498.1 2102394 2102849 R identified by match to protein family HMM PF07012; cryptic curlin major subunit complement(2102394..2102849) Escherichia coli SMS-3-5 6147255 YP_001744142.1 CDS csgB NC_010498.1 2102890 2103372 R CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit complement(2102890..2103372) Escherichia coli SMS-3-5 6144044 YP_001744143.1 CDS EcSMS35_2091 NC_010498.1 2103448 2103633 D identified by Glimmer3; putative; hypothetical protein 2103448..2103633 Escherichia coli SMS-3-5 6143570 YP_001744144.1 CDS EcSMS35_2092 NC_010498.1 2103986 2104117 R identified by Glimmer3; putative; hypothetical protein complement(2103986..2104117) Escherichia coli SMS-3-5 6145409 YP_001744145.1 CDS csgD NC_010498.1 2104178 2104750 D activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 2104178..2104750 Escherichia coli SMS-3-5 6144376 YP_001744146.1 CDS csgE NC_010498.1 2104755 2105144 D chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 2104755..2105144 Escherichia coli SMS-3-5 6146356 YP_001744147.1 CDS csgF NC_010498.1 2105169 2105585 D nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 2105169..2105585 Escherichia coli SMS-3-5 6145518 YP_001744148.1 CDS csgG NC_010498.1 2105612 2106445 D identified by match to protein family HMM PF03783; curli production assembly/transport subunit CsgG 2105612..2106445 Escherichia coli SMS-3-5 6144213 YP_001744149.1 CDS EcSMS35_2097 NC_010498.1 2106509 2107030 R identified by match to protein family HMM PF06496; hypothetical protein complement(2106509..2107030) Escherichia coli SMS-3-5 6143467 YP_001744150.1 CDS EcSMS35_2098 NC_010498.1 2107102 2107656 R identified by match to protein family HMM PF06192; chaperone TorD complement(2107102..2107656) Escherichia coli SMS-3-5 6145154 YP_001744151.1 CDS EcSMS35_2099 NC_010498.1 2107680 2108417 R identified by match to protein family HMM PF02811; putative hydrolase complement(2107680..2108417) Escherichia coli SMS-3-5 6144595 YP_001744152.1 CDS EcSMS35_2100 NC_010498.1 2108472 2109410 R identified by match to protein family HMM PF02826; D-isomer specific 2-hydroxyacid dehydrogenase family protein complement(2108472..2109410) Escherichia coli SMS-3-5 6146252 YP_001744153.1 CDS EcSMS35_2102 NC_010498.1 2109823 2110509 R identified by similarity to GB:AAZ87768.1; hypothetical protein complement(2109823..2110509) Escherichia coli SMS-3-5 6143679 YP_001744154.1 CDS phoH NC_010498.1 2111072 2112136 R identified by match to protein family HMM PF02562; hypothetical protein complement(2111072..2112136) Escherichia coli SMS-3-5 6143540 YP_001744155.1 CDS EcSMS35_2104 NC_010498.1 2112481 2113752 R identified by match to protein family HMM PF04261; match to protein family HMM TIGR01409; match to protein family HMM TIGR01412; match to protein family HMM TIGR01413; Tat-translocated enzyme complement(2112481..2113752) Escherichia coli SMS-3-5 6142769 YP_001744156.1 CDS EcSMS35_2105 NC_010498.1 2113758 2114885 R identified by match to protein family HMM PF04302; hypothetical protein complement(2113758..2114885) Escherichia coli SMS-3-5 6144740 YP_001744157.1 CDS EcSMS35_2106 NC_010498.1 2114943 2115773 R identified by match to protein family HMM PF03239; match to protein family HMM TIGR00145; iron permease FTR1 family protein complement(2114943..2115773) Escherichia coli SMS-3-5 6146212 YP_001744158.1 CDS EcSMS35_2107 NC_010498.1 2115809 2115937 D identified by Glimmer3; putative; hypothetical protein 2115809..2115937 Escherichia coli SMS-3-5 6143291 YP_001744159.1 CDS putP NC_010498.1 2115993 2117501 R identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; match to protein family HMM TIGR02121; sodium/proline symporter complement(2115993..2117501) Escherichia coli SMS-3-5 6147531 YP_001744160.1 CDS EcSMS35_2109 NC_010498.1 2117491 2117628 R identified by Glimmer3; putative; hypothetical protein complement(2117491..2117628) Escherichia coli SMS-3-5 6146844 YP_001744161.1 CDS EcSMS35_2110 NC_010498.1 2117660 2117869 R hypothetical protein complement(2117660..2117869) Escherichia coli SMS-3-5 6146173 YP_001744162.1 CDS putA NC_010498.1 2117924 2121886 D proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 2117924..2121886 Escherichia coli SMS-3-5 6146110 YP_001744163.1 CDS rutR NC_010498.1 2121926 2122564 R identified by match to protein family HMM PF00440; match to protein family HMM PF08362; transcriptional regulator RutR complement(2121926..2122564) Escherichia coli SMS-3-5 6145284 YP_001744164.1 CDS EcSMS35_2113 NC_010498.1 2122852 2123943 D identified by match to protein family HMM PF00296; putative monooxygenase rutA 2122852..2123943 Escherichia coli SMS-3-5 6144746 YP_001744165.1 CDS EcSMS35_2114 NC_010498.1 2123940 2124635 D identified by match to protein family HMM PF00857; putative isochorismatase family protein, rutB 2123940..2124635 Escherichia coli SMS-3-5 6144242 YP_001744166.1 CDS EcSMS35_2115 NC_010498.1 2124647 2125033 D identified by match to protein family HMM PF01042; rutC protein 2124647..2125033 Escherichia coli SMS-3-5 6147337 YP_001744167.1 CDS EcSMS35_2116 NC_010498.1 2125041 2125853 D identified by match to protein family HMM PF00561; putative rutD protein 2125041..2125853 Escherichia coli SMS-3-5 6144556 YP_001744168.1 CDS EcSMS35_2117 NC_010498.1 2125850 2126440 D identified by match to protein family HMM PF00881; hypothetical protein 2125850..2126440 Escherichia coli SMS-3-5 6145613 YP_001744169.1 CDS EcSMS35_2118 NC_010498.1 2126451 2126945 D identified by match to protein family HMM PF01613; putative flavin reductase rutF 2126451..2126945 Escherichia coli SMS-3-5 6146174 YP_001744170.1 CDS EcSMS35_2119 NC_010498.1 2126966 2128294 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; putative purine permease ycdG 2126966..2128294 Escherichia coli SMS-3-5 6144652 YP_001744171.1 CDS wrbA NC_010498.1 2128923 2129519 D stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 2128923..2129519 Escherichia coli SMS-3-5 6145176 YP_001744172.1 CDS EcSMS35_2121 NC_010498.1 2129540 2129767 D hypothetical protein 2129540..2129767 Escherichia coli SMS-3-5 6143485 YP_001744173.1 CDS agp NC_010498.1 2129805 2131046 R identified by match to protein family HMM PF00328; glucose-1-phosphatase/inositol phosphatase complement(2129805..2131046) Escherichia coli SMS-3-5 6144128 YP_001744174.1 CDS EcSMS35_2123 NC_010498.1 2131339 2132175 R hypothetical protein complement(2131339..2132175) Escherichia coli SMS-3-5 6147454 YP_001744175.1 CDS cbpA NC_010498.1 2132855 2133775 D functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 2132855..2133775 Escherichia coli SMS-3-5 6142934 YP_001744176.1 CDS cbpM NC_010498.1 2133775 2134080 D with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 2133775..2134080 Escherichia coli SMS-3-5 6146404 YP_001744177.1 CDS torD NC_010498.1 2134232 2134831 R TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD complement(2134232..2134831) Escherichia coli SMS-3-5 6146952 YP_001744178.1 CDS torA NC_010498.1 2134828 2137374 R identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; match to protein family HMM TIGR01409; match to protein family HMM TIGR02164; trimethylamine-N-oxide reductase complement(2134828..2137374) Escherichia coli SMS-3-5 6144206 YP_001744179.1 CDS torC NC_010498.1 2137374 2138546 R identified by match to protein family HMM PF03264; match to protein family HMM TIGR02162; cytochrome c-type protein torC complement(2137374..2138546) Escherichia coli SMS-3-5 6143592 YP_001744180.1 CDS torR NC_010498.1 2138676 2139368 D response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 2138676..2139368 Escherichia coli SMS-3-5 6144708 YP_001744181.1 CDS torT NC_010498.1 2139341 2140369 R periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT complement(2139341..2140369) Escherichia coli SMS-3-5 6146354 YP_001744182.1 CDS torS NC_010498.1 2140482 2143184 D Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 2140482..2143184 Escherichia coli SMS-3-5 6144177 YP_001744183.1 CDS EcSMS35_2132 NC_010498.1 2143267 2144340 D identified by match to protein family HMM PF00037; 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein 2143267..2144340 Escherichia coli SMS-3-5 6145244 YP_001744184.1 CDS EcSMS35_2133 NC_010498.1 2144389 2144562 R identified by match to protein family HMM PF08178; GnsA/GnsB family transcriptional regulator complement(2144389..2144562) Escherichia coli SMS-3-5 6146941 YP_001744185.1 CDS EcSMS35_2134 NC_010498.1 2144757 2144876 R identified by Glimmer3; putative; hypothetical protein complement(2144757..2144876) Escherichia coli SMS-3-5 6146343 YP_001744186.1 CDS EcSMS35_2135 NC_010498.1 2144956 2145168 R identified by match to protein family HMM PF00313; cold shock protein CspG complement(2144956..2145168) Escherichia coli SMS-3-5 6143047 YP_001744187.1 CDS cspH NC_010498.1 2145454 2145666 D identified by match to protein family HMM PF00313; cold-shock DNA-binding domain-containing protein CspH 2145454..2145666 Escherichia coli SMS-3-5 6147411 YP_001744188.1 CDS appA NC_010498.1 2145654 2146964 R identified by similarity to SP:P07102; match to protein family HMM PF00328; phosphoanhydride phosphorylase complement(2145654..2146964) Escherichia coli SMS-3-5 6143340 YP_001744189.1 CDS appB NC_010498.1 2147149 2148285 R identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203; cytochrome bd-II oxidase, subunit II complement(2147149..2148285) Escherichia coli SMS-3-5 6146375 YP_001744190.1 CDS appC NC_010498.1 2148297 2149841 R identified by match to protein family HMM PF01654; cytochrome bd-II oxidase, subunit I complement(2148297..2149841) Escherichia coli SMS-3-5 6142814 YP_001744191.1 CDS hyaF NC_010498.1 2149975 2150832 R identified by match to protein family HMM PF04809; hydrogenase-1 operon protein HyaF complement(2149975..2150832) Escherichia coli SMS-3-5 6144796 YP_001744192.1 CDS hyaE NC_010498.1 2150829 2151227 R involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE complement(2150829..2151227) Escherichia coli SMS-3-5 6146109 YP_001744193.1 CDS hyaD NC_010498.1 2151224 2151811 R HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease complement(2151224..2151811) Escherichia coli SMS-3-5 6145585 YP_001744194.1 CDS hyaC NC_010498.1 2151808 2152515 R identified by match to protein family HMM PF01292; match to protein family HMM TIGR02125; hydrogenase 1 b-type cytochrome subunit complement(2151808..2152515) Escherichia coli SMS-3-5 6144926 YP_001744195.1 CDS hyaB NC_010498.1 2152534 2154327 R involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit complement(2152534..2154327) Escherichia coli SMS-3-5 6146942 YP_001744196.1 CDS hyaA NC_010498.1 2154324 2155442 R identified by match to protein family HMM PF01058; match to protein family HMM PF08425; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; nickel-dependent hydrogenase 1, small subunit complement(2154324..2155442) Escherichia coli SMS-3-5 6143203 YP_001744197.1 CDS EcSMS35_2146 NC_010498.1 2155643 2155855 D identified by Glimmer3; putative; hypothetical protein 2155643..2155855 Escherichia coli SMS-3-5 6142657 YP_001744198.1 CDS EcSMS35_2148 NC_010498.1 2156163 2156822 D identified by match to protein family HMM PF01027; hypothetical protein 2156163..2156822 Escherichia coli SMS-3-5 6143703 YP_001744199.1 CDS tusE NC_010498.1 2156914 2157243 D transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 2156914..2157243 Escherichia coli SMS-3-5 6144960 YP_001744200.1 CDS EcSMS35_2149 NC_010498.1 2157240 2157518 R catalyzes the hydrolysis of acylphosphate; acylphosphatase complement(2157240..2157518) Escherichia coli SMS-3-5 6146264 YP_001744201.1 CDS EcSMS35_2151 NC_010498.1 2157613 2158803 D identified by match to protein family HMM PF03602; hypothetical protein 2157613..2158803 Escherichia coli SMS-3-5 6143058 YP_001744202.1 CDS EcSMS35_2152 NC_010498.1 2158861 2159178 D identified by match to protein family HMM PF08755; match to protein family HMM TIGR02097; heat shock protein HspQ 2158861..2159178 Escherichia coli SMS-3-5 6144607 YP_001744203.1 CDS EcSMS35_2153 NC_010498.1 2159223 2159636 R identified by match to protein family HMM PF02629; putative CoA-binding protein complement(2159223..2159636) Escherichia coli SMS-3-5 6143949 YP_001744204.1 CDS EcSMS35_2154 NC_010498.1 2159599 2159769 D identified by Glimmer3; putative; hypothetical protein 2159599..2159769 Escherichia coli SMS-3-5 6145594 YP_001744205.1 CDS EcSMS35_2155 NC_010498.1 2159809 2160471 D hypothetical protein 2159809..2160471 Escherichia coli SMS-3-5 6144929 YP_001744206.1 CDS mgsA NC_010498.1 2160568 2161026 D catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 2160568..2161026 Escherichia coli SMS-3-5 6147301 YP_001744207.1 CDS helD NC_010498.1 2161058 2163112 R catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV complement(2161058..2163112) Escherichia coli SMS-3-5 6146618 YP_001744208.1 CDS EcSMS35_2158 NC_010498.1 2163235 2163681 D identified by match to protein family HMM PF03733; hypothetical protein 2163235..2163681 Escherichia coli SMS-3-5 6146026 YP_001744209.1 CDS EcSMS35_2160 NC_010498.1 2163691 2165853 D identified by match to protein family HMM PF05976; match to protein family HMM TIGR01666; match to protein family HMM TIGR01667; hypothetical protein 2163691..2165853 Escherichia coli SMS-3-5 6145516 YP_001744210.1 CDS EcSMS35_2159 NC_010498.1 2165816 2166445 R identified by match to protein family HMM PF04993; match to protein family HMM PF04994; TfoX family protein complement(2165816..2166445) Escherichia coli SMS-3-5 6144060 YP_001744211.1 CDS sulA NC_010498.1 2166664 2167173 D identified by match to protein family HMM PF03846; match to protein family HMM TIGR00623; SOS cell division inhibitor 2166664..2167173 Escherichia coli SMS-3-5 6144659 YP_001744212.1 CDS EcSMS35_2161 NC_010498.1 2167157 2167327 R identified by Glimmer3; putative; hypothetical protein complement(2167157..2167327) Escherichia coli SMS-3-5 6143027 YP_001744213.1 CDS ompA NC_010498.1 2167505 2168581 D OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 2167505..2168581 Escherichia coli SMS-3-5 6146246 YP_001744214.1 CDS EcSMS35_2164 NC_010498.1 2168657 2169109 R identified by match to protein family HMM PF06303; hypothetical protein complement(2168657..2169109) Escherichia coli SMS-3-5 6146054 YP_001744215.1 CDS EcSMS35_2165 NC_010498.1 2169295 2171055 D S16 family peptidase 2169295..2171055 Escherichia coli SMS-3-5 6145397 YP_001744216.1 CDS fabA NC_010498.1 2171124 2171642 D catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 2171124..2171642 Escherichia coli SMS-3-5 6144032 YP_001744217.1 CDS EcSMS35_2167 NC_010498.1 2172135 2172698 R identified by match to protein family HMM PF03886; putative lipoprotein complement(2172135..2172698) Escherichia coli SMS-3-5 6145752 YP_001744218.1 CDS pqiB NC_010498.1 2172695 2174335 R identified by match to protein family HMM PF02470; paraquat-inducible protein B complement(2172695..2174335) Escherichia coli SMS-3-5 6146633 YP_001744219.1 CDS pqiA NC_010498.1 2174340 2175593 R identified by match to protein family HMM PF04403; match to protein family HMM TIGR00155; paraquat-inducible protein A complement(2174340..2175593) Escherichia coli SMS-3-5 6147320 YP_001744220.1 CDS uup NC_010498.1 2175723 2177630 R Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC ABC transporter ATPase complement(2175723..2177630) Escherichia coli SMS-3-5 6144963 YP_001744221.1 CDS rlmL NC_010498.1 2177642 2179750 R catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase complement(2177642..2179750) Escherichia coli SMS-3-5 6145620 YP_001744222.1 CDS EcSMS35_2173 NC_010498.1 2179848 2180957 D identified by match to protein family HMM PF00111; match to protein family HMM PF03473; match to protein family HMM PF03476; MOSC domain-containing protein 2179848..2180957 Escherichia coli SMS-3-5 6142636 YP_001744223.1 CDS EcSMS35_2172 NC_010498.1 2180954 2181496 R identified by match to protein family HMM PF07126; hypothetical protein complement(2180954..2181496) Escherichia coli SMS-3-5 6146215 YP_001744224.1 CDS pyrD NC_010498.1 2181670 2182680 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(2181670..2182680) Escherichia coli SMS-3-5 6143184 YP_001744225.1 CDS EcSMS35_2175 NC_010498.1 2182791 2183480 R identified by match to protein family HMM PF00345; match to protein family HMM PF02753; putativi pili assembly chaperone complement(2182791..2183480) Escherichia coli SMS-3-5 6146742 YP_001744226.1 CDS EcSMS35_2176 NC_010498.1 2183494 2184006 R identified by match to protein family HMM PF00419; fimbrial protein complement(2183494..2184006) Escherichia coli SMS-3-5 6146076 YP_001744227.1 CDS EcSMS35_2177 NC_010498.1 2184017 2184469 R identified by match to protein family HMM PF00419; fimbrial protein complement(2184017..2184469) Escherichia coli SMS-3-5 6146479 YP_001744228.1 CDS EcSMS35_2178 NC_010498.1 2184571 2185641 R identified by match to protein family HMM PF00419; putative fimbrial protein complement(2184571..2185641) Escherichia coli SMS-3-5 6147382 YP_001744229.1 CDS EcSMS35_2179 NC_010498.1 2185632 2188232 R identified by match to protein family HMM PF00577; outer membrane usher protein fimD-like protein complement(2185632..2188232) Escherichia coli SMS-3-5 6143011 YP_001744230.1 CDS EcSMS35_2180 NC_010498.1 2188257 2188931 R identified by match to protein family HMM PF00345; match to protein family HMM PF02753; periplasmic pilus chaperone family protein complement(2188257..2188931) Escherichia coli SMS-3-5 6146314 YP_001744231.1 CDS EcSMS35_2181 NC_010498.1 2189039 2189578 R identified by match to protein family HMM PF00419; putative fimbrial protein complement(2189039..2189578) Escherichia coli SMS-3-5 6147005 YP_001744232.1 CDS EcSMS35_2182 NC_010498.1 2189933 2190508 D identified by match to protein family HMM PF02525; match to protein family HMM PF03358; NAD(P)H-dependent FMN reductase 2189933..2190508 Escherichia coli SMS-3-5 6143983 YP_001744233.1 CDS EcSMS35_2183 NC_010498.1 2190501 2191460 D part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 2190501..2191460 Escherichia coli SMS-3-5 6144480 YP_001744234.1 CDS ssuD NC_010498.1 2191457 2192602 D catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 2191457..2192602 Escherichia coli SMS-3-5 6142745 YP_001744235.1 CDS ssuC NC_010498.1 2192611 2193405 D part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit 2192611..2193405 Escherichia coli SMS-3-5 6144430 YP_001744236.1 CDS ssuB NC_010498.1 2193402 2194169 D part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 2193402..2194169 Escherichia coli SMS-3-5 6147302 YP_001744237.1 CDS pepN NC_010498.1 2194212 2196824 R identified by match to protein family HMM PF01433; match to protein family HMM TIGR02414; aminopeptidase N complement(2194212..2196824) Escherichia coli SMS-3-5 6142897 YP_001744238.1 CDS EcSMS35_2188 NC_010498.1 2196860 2196982 R hypothetical protein complement(2196860..2196982) Escherichia coli SMS-3-5 6142943 YP_001744239.1 CDS pncB NC_010498.1 2197090 2198292 D catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 2197090..2198292 Escherichia coli SMS-3-5 6143475 YP_001744240.1 CDS asnC NC_010498.1 2198460 2199860 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 2198460..2199860 Escherichia coli SMS-3-5 6146514 YP_001744241.1 CDS ompF NC_010498.1 2200462 2201535 D outer membrane porin F; 1a; Ia; b; outer membrane protein F 2200462..2201535 Escherichia coli SMS-3-5 6147079 YP_001744242.1 CDS aspC NC_010498.1 2201720 2202910 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 2201720..2202910 Escherichia coli SMS-3-5 6146560 YP_001744243.1 CDS EcSMS35_2193 NC_010498.1 2202960 2203607 R identified by match to protein family HMM PF00753; metallo-beta-lactamase family protein complement(2202960..2203607) Escherichia coli SMS-3-5 6146344 YP_001744244.1 CDS EcSMS35_2194 NC_010498.1 2203634 2204182 R identified by match to protein family HMM PF05951; match to protein family HMM PF08291; match to protein family HMM TIGR01409; Tat pathway signal sequence domain-containing protein complement(2203634..2204182) Escherichia coli SMS-3-5 6144518 YP_001744245.1 CDS EcSMS35_2195 NC_010498.1 2204363 2206210 R identified by match to protein family HMM PF01471; hypothetical protein complement(2204363..2206210) Escherichia coli SMS-3-5 6145177 YP_001744246.1 CDS mukB NC_010498.1 2206471 2210931 R SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB complement(2206471..2210931) Escherichia coli SMS-3-5 6143029 YP_001744247.1 CDS mukE NC_010498.1 2210931 2211635 R acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E complement(2210931..2211635) Escherichia coli SMS-3-5 6143870 YP_001744248.1 CDS mukF NC_010498.1 2211616 2212938 R acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F complement(2211616..2212938) Escherichia coli SMS-3-5 6142992 YP_001744249.1 CDS smtA NC_010498.1 2212935 2213720 R involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA complement(2212935..2213720) Escherichia coli SMS-3-5 6143825 YP_001744250.1 CDS EcSMS35_2201 NC_010498.1 2213856 2214635 D identified by match to protein family HMM PF02698; hypothetical protein 2213856..2214635 Escherichia coli SMS-3-5 6142894 YP_001744251.1 CDS EcSMS35_2200 NC_010498.1 2214612 2215505 R hypothetical protein complement(2214612..2215505) Escherichia coli SMS-3-5 6145286 YP_001744252.1 CDS kdsB NC_010498.1 2215659 2216405 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(2215659..2216405) Escherichia coli SMS-3-5 6143604 YP_001744253.1 CDS EcSMS35_2203 NC_010498.1 2216402 2216584 R identified by match to protein family HMM PF03966; hypothetical protein complement(2216402..2216584) Escherichia coli SMS-3-5 6145918 YP_001744254.1 CDS EcSMS35_2204 NC_010498.1 2216636 2217868 R identified by match to protein family HMM PF06224; hypothetical protein complement(2216636..2217868) Escherichia coli SMS-3-5 6144226 YP_001744255.1 CDS lpxK NC_010498.1 2217905 2218891 R transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase complement(2217905..2218891) Escherichia coli SMS-3-5 6144902 YP_001744256.1 CDS msbA NC_010498.1 2218888 2220636 R involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease complement(2218888..2220636) Escherichia coli SMS-3-5 6147458 YP_001744257.1 CDS EcSMS35_2207 NC_010498.1 2220673 2222937 R ycaI; identified by match to protein family HMM PF00753; match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; hypothetical protein complement(2220673..2222937) Escherichia coli SMS-3-5 6144268 YP_001744258.1 CDS ihfB NC_010498.1 2223143 2223427 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta complement(2223143..2223427) Escherichia coli SMS-3-5 6143068 YP_001744259.1 CDS rpsA NC_010498.1 2223587 2225260 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(2223587..2225260) Escherichia coli SMS-3-5 6147453 YP_001744260.1 CDS cmk NC_010498.1 2225371 2226054 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(2225371..2226054) Escherichia coli SMS-3-5 6146899 YP_001744261.1 CDS EcSMS35_2211 NC_010498.1 2226227 2226991 R identified by match to protein family HMM PF01435; M48B family peptidase complement(2226227..2226991) Escherichia coli SMS-3-5 6146392 YP_001744262.1 CDS EcSMS35_2212 NC_010498.1 2227127 2228455 R identified by match to protein family HMM PF01609; IS4 transposase complement(2227127..2228455) Escherichia coli SMS-3-5 6144635 YP_001744263.1 CDS aroA NC_010498.1 2228599 2229882 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(2228599..2229882) Escherichia coli SMS-3-5 6144147 YP_001744264.1 CDS serC NC_010498.1 2229953 2231041 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(2229953..2231041) Escherichia coli SMS-3-5 6143213 YP_001744265.1 CDS EcSMS35_2215 NC_010498.1 2231240 2231932 R identified by match to protein family HMM PF04239; hypothetical protein complement(2231240..2231932) Escherichia coli SMS-3-5 6142672 YP_001744266.1 CDS EcSMS35_2216 NC_010498.1 2232062 2233822 D identified by match to protein family HMM PF02624; match to protein family HMM TIGR00702; hypothetical protein 2232062..2233822 Escherichia coli SMS-3-5 6146396 YP_001744267.1 CDS EcSMS35_2217 NC_010498.1 2234228 2235085 D identified by match to protein family HMM PF01226; match to protein family HMM TIGR00790; formate transporter 2234228..2235085 Escherichia coli SMS-3-5 6143248 YP_001744268.1 CDS pflB2 NC_010498.1 2235140 2237422 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 2235140..2237422 Escherichia coli SMS-3-5 6144248 YP_001744269.1 CDS pflA NC_010498.1 2237614 2238354 D activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 2237614..2238354 Escherichia coli SMS-3-5 6145972 YP_001744270.1 CDS EcSMS35_2220 NC_010498.1 2238564 2239994 R identified by match to protein family HMM PF00324; amino acid permease family protein complement(2238564..2239994) Escherichia coli SMS-3-5 6145436 YP_001744271.1 CDS EcSMS35_2221 NC_010498.1 2240204 2241352 R identified by match to protein family HMM PF07690; putative MFS family transporter protein complement(2240204..2241352) Escherichia coli SMS-3-5 6145050 YP_001744272.1 CDS EcSMS35_2222 NC_010498.1 2241383 2241511 D identified by Glimmer3; putative; hypothetical protein 2241383..2241511 Escherichia coli SMS-3-5 6146918 YP_001744273.1 CDS EcSMS35_2223 NC_010498.1 2241667 2242293 D ycaC; identified by match to protein family HMM PF00857; isochorismatase family protein 2241667..2242293 Escherichia coli SMS-3-5 6146401 YP_001744274.1 CDS dmsC1 NC_010498.1 2242329 2243192 R identified by match to protein family HMM PF04976; anaerobic dimethyl sulfoxide reductase, C subunit complement(2242329..2243192) Escherichia coli SMS-3-5 6143457 YP_001744275.1 CDS dmsB_2 NC_010498.1 2243194 2243811 R identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951; dimethylsulfoxide reductase, B subunit complement(2243194..2243811) Escherichia coli SMS-3-5 6142942 YP_001744276.1 CDS dmsA NC_010498.1 2243822 2246266 R identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166; anaerobic dimethyl sulfoxide reductase, A subunit complement(2243822..2246266) Escherichia coli SMS-3-5 6144877 YP_001744277.1 CDS serS NC_010498.1 2246505 2247797 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(2246505..2247797) Escherichia coli SMS-3-5 6144327 YP_001744278.1 CDS EcSMS35_2228 NC_010498.1 2247888 2249231 R identified by match to protein family HMM PF00004; recombination factor protein RarA complement(2247888..2249231) Escherichia coli SMS-3-5 6147231 YP_001744279.1 CDS lolA NC_010498.1 2249242 2249853 R participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein complement(2249242..2249853) Escherichia coli SMS-3-5 6146700 YP_001744280.1 CDS ftsK NC_010498.1 2250012 2254121 R DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK complement(2250012..2254121) Escherichia coli SMS-3-5 6143319 YP_001744281.1 CDS lrp NC_010498.1 2254256 2254750 R mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator complement(2254256..2254750) Escherichia coli SMS-3-5 6142765 YP_001744282.1 CDS EcSMS35_2232 NC_010498.1 2255113 2255226 R identified by Glimmer3; putative; hypothetical protein complement(2255113..2255226) Escherichia coli SMS-3-5 6144022 YP_001744283.1 CDS trxB NC_010498.1 2255295 2256260 D catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 2255295..2256260 Escherichia coli SMS-3-5 6145688 YP_001744284.1 CDS cydD NC_010498.1 2256383 2258149 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 2256383..2258149 Escherichia coli SMS-3-5 6145064 YP_001744285.1 CDS cudC NC_010498.1 2258150 2259871 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 2258150..2259871 Escherichia coli SMS-3-5 6146794 YP_001744286.1 CDS aat NC_010498.1 2259913 2260617 D leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 2259913..2260617 Escherichia coli SMS-3-5 6146577 YP_001744287.1 CDS infA NC_010498.1 2260902 2261120 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2260902..2261120 Escherichia coli SMS-3-5 6143517 YP_001744288.1 CDS EcSMS35_2239 NC_010498.1 2261611 2262453 R hypothetical protein complement(2261611..2262453) Escherichia coli SMS-3-5 6143643 YP_001744289.1 CDS EcSMS35_2240 NC_010498.1 2262538 2262735 R identified by match to protein family HMM PF06117; hypothetical protein complement(2262538..2262735) Escherichia coli SMS-3-5 6145959 YP_001744290.1 CDS EcSMS35_2241 NC_010498.1 2262752 2263240 R hypothetical protein complement(2262752..2263240) Escherichia coli SMS-3-5 6144086 YP_001744291.1 CDS EcSMS35_2242 NC_010498.1 2263237 2263620 R identified by match to protein family HMM PF06755; hypothetical protein complement(2263237..2263620) Escherichia coli SMS-3-5 6144500 YP_001744292.1 CDS EcSMS35_2243 NC_010498.1 2263697 2264185 R identified by match to protein family HMM PF06154; YagB/YeeU/YfjZ family protein complement(2263697..2264185) Escherichia coli SMS-3-5 6144630 YP_001744293.1 CDS EcSMS35_2244 NC_010498.1 2264088 2264771 R hypothetical protein complement(2264088..2264771) Escherichia coli SMS-3-5 6143057 YP_001744294.1 CDS EcSMS35_2245 NC_010498.1 2264790 2265011 R identified by match to protein family HMM PF06174; hypothetical protein complement(2264790..2265011) Escherichia coli SMS-3-5 6146270 YP_001744295.1 CDS EcSMS35_2246 NC_010498.1 2265074 2265550 R identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein complement(2265074..2265550) Escherichia coli SMS-3-5 6146227 YP_001744296.1 CDS EcSMS35_2247 NC_010498.1 2265566 2266051 R identified by match to protein family HMM PF03230; antirestriction protein complement(2265566..2266051) Escherichia coli SMS-3-5 6146744 YP_001744297.1 CDS EcSMS35_2248 NC_010498.1 2266143 2266961 R identified by match to protein family HMM PF06067; hypothetical protein complement(2266143..2266961) Escherichia coli SMS-3-5 6145456 YP_001744298.1 CDS flu1 NC_010498.1 2267288 2270134 R identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; antigen 43 complement(2267288..2270134) Escherichia coli SMS-3-5 6143968 YP_001744299.1 CDS EcSMS35_2250 NC_010498.1 2270145 2270258 R identified by Glimmer3; putative; hypothetical protein complement(2270145..2270258) Escherichia coli SMS-3-5 6144882 YP_001744300.1 CDS EcSMS35_2251 NC_010498.1 2270506 2271378 R identified by match to protein family HMM PF01926; putative GTPase complement(2270506..2271378) Escherichia coli SMS-3-5 6142816 YP_001744301.1 CDS hsdM NC_010498.1 2271642 2273213 D identified by match to protein family HMM PF02384; match to protein family HMM TIGR00497; type I restriction-modification system, M subunit 2271642..2273213 Escherichia coli SMS-3-5 6147463 YP_001744302.1 CDS EcSMS35_2252 NC_010498.1 2273207 2273710 R identified by match to protein family HMM PF03400; IS1 transposase orfB complement(2273207..2273710) Escherichia coli SMS-3-5 6146279 YP_001744303.1 CDS EcSMS35_2254 NC_010498.1 2273721 2273933 R IS1 transposase orfA complement(2273721..2273933) Escherichia coli SMS-3-5 6146641 YP_001744304.1 CDS EcSMS35_2255 NC_010498.1 2274063 2276285 R identified by match to protein family HMM PF00534; match to protein family HMM PF00535; glycosyl transferase, group 1/glycosyl transferase, group 2 complement(2274063..2276285) Escherichia coli SMS-3-5 6144538 YP_001744305.1 CDS EcSMS35_2256 NC_010498.1 2276383 2277192 D identified by similarity to GB:ABM38486.1; hypothetical protein 2276383..2277192 Escherichia coli SMS-3-5 6146981 YP_001744306.1 CDS EcSMS35_2257 NC_010498.1 2278306 2279298 D identified by match to protein family HMM PF01609; IS5 transposase 2278306..2279298 Escherichia coli SMS-3-5 6145242 YP_001744307.1 CDS EcSMS35_2258 NC_010498.1 2279746 2280636 R identified by match to protein family HMM PF00665; IS629 transposase orfB complement(2279746..2280636) Escherichia coli SMS-3-5 6144875 YP_001744308.1 CDS EcSMS35_2259 NC_010498.1 2280633 2280959 R IS629 transposase orfA complement(2280633..2280959) Escherichia coli SMS-3-5 6143364 YP_001744309.1 CDS EcSMS35_2261 NC_010498.1 2282078 2283001 R identified by match to protein family HMM PF01609; IS903 transposase complement(2282078..2283001) Escherichia coli SMS-3-5 6145092 YP_001744310.1 CDS EcSMS35_2262 NC_010498.1 2283048 2284208 R identified by match to protein family HMM PF00535; glycosyl transferase, group 2 complement(2283048..2284208) Escherichia coli SMS-3-5 6145675 YP_001744311.1 CDS EcSMS35_2263 NC_010498.1 2284330 2285463 R identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein complement(2284330..2285463) Escherichia coli SMS-3-5 6145742 YP_001744312.1 CDS EcSMS35_2264 NC_010498.1 2285476 2286366 R identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(2285476..2286366) Escherichia coli SMS-3-5 6143748 YP_001744313.1 CDS glf NC_010498.1 2286363 2287517 R identified by match to protein family HMM PF03275; match to protein family HMM TIGR00031; UDP-galactopyranose mutase complement(2286363..2287517) Escherichia coli SMS-3-5 6144907 YP_001744314.1 CDS EcSMS35_2266 NC_010498.1 2287536 2289428 R identified by match to protein family HMM PF01501; glycosyl transferase family protein complement(2287536..2289428) Escherichia coli SMS-3-5 6144263 YP_001744315.1 CDS rfbB NC_010498.1 2289443 2290183 R identified by similarity to SP:Q48479; match to protein family HMM PF00005; O-antigen export system ATP-binding protein RfbB complement(2289443..2290183) Escherichia coli SMS-3-5 6143755 YP_001744316.1 CDS EcSMS35_2268 NC_010498.1 2290183 2290962 R identified by similarity to SP:Q48475; match to protein family HMM PF01061; O-antigen export system permease RfbA complement(2290183..2290962) Escherichia coli SMS-3-5 6145045 YP_001744317.1 CDS EcSMS35_2269 NC_010498.1 2291713 2291850 D identified by Glimmer3; putative; hypothetical protein 2291713..2291850 Escherichia coli SMS-3-5 6146778 YP_001744318.1 CDS EcSMS35_2270 NC_010498.1 2292197 2292328 D identified by Glimmer3; putative; hypothetical protein 2292197..2292328 Escherichia coli SMS-3-5 6146278 YP_001744319.1 CDS EcSMS35_2271 NC_010498.1 2292408 2292560 D identified by Glimmer3; putative; hypothetical protein 2292408..2292560 Escherichia coli SMS-3-5 6143356 YP_001744320.1 CDS EcSMS35_2272 NC_010498.1 2292586 2294205 D identified by match to protein family HMM PF01610; ISL3 family transposase 2292586..2294205 Escherichia coli SMS-3-5 6144701 YP_001744321.1 CDS EcSMS35_2274 NC_010498.1 2295950 2296513 R identified by similarity to GB:AAL08430.1; hypothetical protein complement(2295950..2296513) Escherichia coli SMS-3-5 6143980 YP_001744322.1 CDS EcSMS35_2275 NC_010498.1 2297723 2299546 R identified by similarity to GB:AAL08429.1; hypothetical protein complement(2297723..2299546) Escherichia coli SMS-3-5 6146763 YP_001744323.1 CDS EcSMS35_2276 NC_010498.1 2299911 2301476 D identified by similarity to GB:AAL08427.1; hypothetical protein 2299911..2301476 Escherichia coli SMS-3-5 6147043 YP_001744324.1 CDS EcSMS35_2277 NC_010498.1 2301700 2302908 R identified by match to protein family HMM PF00589; phage integrase family site specific recombinase complement(2301700..2302908) Escherichia coli SMS-3-5 6146630 YP_001744325.1 CDS clpA NC_010498.1 2303366 2305642 R ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit complement(2303366..2305642) Escherichia coli SMS-3-5 6144626 YP_001744326.1 CDS clpS NC_010498.1 2305673 2305993 R involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS complement(2305673..2305993) Escherichia coli SMS-3-5 6144117 YP_001744327.1 CDS cspD NC_010498.1 2306316 2306540 D inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 2306316..2306540 Escherichia coli SMS-3-5 6143199 YP_001744328.1 CDS macB NC_010498.1 2306613 2308559 R with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease complement(2306613..2308559) Escherichia coli SMS-3-5 6142654 YP_001744329.1 CDS macA NC_010498.1 2308556 2309671 R confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA complement(2308556..2309671) Escherichia coli SMS-3-5 6142945 YP_001744330.1 CDS EcSMS35_2284 NC_010498.1 2309786 2310778 D identified by match to protein family HMM PF04393; hypothetical protein 2309786..2310778 Escherichia coli SMS-3-5 6147268 YP_001744331.1 CDS EcSMS35_2283 NC_010498.1 2310775 2312433 R hypothetical protein complement(2310775..2312433) Escherichia coli SMS-3-5 6144478 YP_001744332.1 CDS aqpZ NC_010498.1 2312859 2313554 D porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 2312859..2313554 Escherichia coli SMS-3-5 6146647 YP_001744333.1 CDS EcSMS35_2286 NC_010498.1 2314068 2315093 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS110 family transposase complement(2314068..2315093) Escherichia coli SMS-3-5 6143500 YP_001744334.1 CDS dusC NC_010498.1 2315324 2316271 R identified by match to protein family HMM PF01207; tRNA-dihydrouridine synthase C complement(2315324..2316271) Escherichia coli SMS-3-5 6146561 YP_001744335.1 CDS EcSMS35_2288 NC_010498.1 2316510 2316908 D identified by match to protein family HMM PF03788; hypothetical protein 2316510..2316908 Escherichia coli SMS-3-5 6145061 YP_001744336.1 CDS EcSMS35_2289 NC_010498.1 2316905 2317600 D identified by match to protein family HMM PF04172; match to protein family HMM TIGR00659; hypothetical protein 2316905..2317600 Escherichia coli SMS-3-5 6145546 YP_001744337.1 CDS cdd NC_010498.1 2317730 2318614 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2317730..2318614 Escherichia coli SMS-3-5 6143970 YP_001744338.1 CDS sanA NC_010498.1 2318764 2319483 D identified by match to protein family HMM PF02698; hypothetical protein 2318764..2319483 Escherichia coli SMS-3-5 6144520 YP_001744339.1 CDS EcSMS35_2292 NC_010498.1 2319486 2319725 D hypothetical protein 2319486..2319725 Escherichia coli SMS-3-5 6142782 YP_001744340.1 CDS EcSMS35_2293 NC_010498.1 2319919 2321157 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2319919..2321157 Escherichia coli SMS-3-5 6143477 YP_001744341.1 CDS EcSMS35_2294 NC_010498.1 2321151 2322386 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2321151..2322386 Escherichia coli SMS-3-5 6143286 YP_001744342.1 CDS mglC NC_010498.1 2322457 2323467 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component complement(2322457..2323467) Escherichia coli SMS-3-5 6147082 YP_001744343.1 CDS mglA NC_010498.1 2323483 2325003 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2323483..2325003) Escherichia coli SMS-3-5 6144584 YP_001744344.1 CDS mglB NC_010498.1 2325064 2326062 R identified by match to protein family HMM PF00532; galactose ABC transporter periplasmic galactose-binding protein complement(2325064..2326062) Escherichia coli SMS-3-5 6143931 YP_001744345.1 CDS galS NC_010498.1 2326342 2327382 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2326342..2327382) Escherichia coli SMS-3-5 6144481 YP_001744346.1 CDS EcSMS35_2299 NC_010498.1 2327524 2328681 R identified by match to protein family HMM PF04171; match to protein family HMM PF04235; hypothetical protein complement(2327524..2328681) Escherichia coli SMS-3-5 6143981 YP_001744347.1 CDS folE NC_010498.1 2328698 2329366 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2328698..2329366) Escherichia coli SMS-3-5 6145521 YP_001744348.1 CDS fghA1 NC_010498.1 2329623 2330459 D identified by match to protein family HMM PF00756; match to protein family HMM TIGR02821; S-formylglutathione hydrolase 2329623..2330459 Escherichia coli SMS-3-5 6144948 YP_001744349.1 CDS cirA NC_010498.1 2330491 2332416 R Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor complement(2330491..2332416) Escherichia coli SMS-3-5 6147114 YP_001744350.1 CDS lysP NC_010498.1 2332774 2334243 R identified by match to protein family HMM PF00324; lysine transporter complement(2332774..2334243) Escherichia coli SMS-3-5 6146570 YP_001744351.1 CDS EcSMS35_2304 NC_010498.1 2334448 2335329 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator complement(2334448..2335329) Escherichia coli SMS-3-5 6143959 YP_001744352.1 CDS EcSMS35_2305 NC_010498.1 2335428 2336477 D identified by match to protein family HMM PF03601; match to protein family HMM TIGR00698; hypothetical protein 2335428..2336477 Escherichia coli SMS-3-5 6146885 YP_001744353.1 CDS nfo NC_010498.1 2336551 2337408 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2336551..2337408 Escherichia coli SMS-3-5 6145278 YP_001744354.1 CDS EcSMS35_2307 NC_010498.1 2337411 2338499 D identified by match to protein family HMM PF00294; match to protein family HMM PF08279; hypothetical protein 2337411..2338499 Escherichia coli SMS-3-5 6145923 YP_001744355.1 CDS EcSMS35_2308 NC_010498.1 2338555 2339805 R identified by match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; NupC family nucleoside transporter complement(2338555..2339805) Escherichia coli SMS-3-5 6142796 YP_001744356.1 CDS rihB NC_010498.1 2339905 2340846 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2339905..2340846) Escherichia coli SMS-3-5 6143353 YP_001744357.1 CDS nsr NC_010498.1 2340976 2341674 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2340976..2341674 Escherichia coli SMS-3-5 6142656 YP_001744358.1 CDS EcSMS35_2311 NC_010498.1 2341742 2342992 R yeiM; identified by match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; NupC family nucleoside transporter complement(2341742..2342992) Escherichia coli SMS-3-5 6143241 YP_001744359.1 CDS EcSMS35_2312 NC_010498.1 2343086 2344024 R identified by match to protein family HMM PF04227; indigoidine synthase A like protein complement(2343086..2344024) Escherichia coli SMS-3-5 6146114 YP_001744360.1 CDS EcSMS35_2313 NC_010498.1 2344012 2344953 R identified by match to protein family HMM PF00294; hypothetical protein complement(2344012..2344953) Escherichia coli SMS-3-5 6146806 YP_001744361.1 CDS fruA NC_010498.1 2345377 2347068 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC complement(2345377..2347068) Escherichia coli SMS-3-5 6144771 YP_001744362.1 CDS fruK NC_010498.1 2347085 2348023 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2347085..2348023) Escherichia coli SMS-3-5 6145452 YP_001744363.1 CDS fruB NC_010498.1 2348023 2349153 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(2348023..2349153) Escherichia coli SMS-3-5 6145993 YP_001744364.1 CDS EcSMS35_2317 NC_010498.1 2349319 2349450 D hypothetical protein 2349319..2349450 Escherichia coli SMS-3-5 6142674 YP_001744365.1 CDS setB NC_010498.1 2349521 2350702 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00899; sugar efflux transporter B 2349521..2350702 Escherichia coli SMS-3-5 6143288 YP_001744366.1 CDS EcSMS35_2318 NC_010498.1 2350699 2350953 R identified by similarity to GB:CAH20558.1; hypothetical protein complement(2350699..2350953) Escherichia coli SMS-3-5 6144707 YP_001744367.1 CDS EcSMS35_2320 NC_010498.1 2351108 2351680 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2351108..2351680 Escherichia coli SMS-3-5 6144088 YP_001744368.1 CDS EcSMS35_2321 NC_010498.1 2351903 2353369 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase family protein 2351903..2353369 Escherichia coli SMS-3-5 6145890 YP_001744369.1 CDS EcSMS35_2322 NC_010498.1 2353487 2354473 D identified by match to protein family HMM PF02492; match to protein family HMM PF07683; CobW/P47K family protein 2353487..2354473 Escherichia coli SMS-3-5 6144317 YP_001744370.1 CDS EcSMS35_2323 NC_010498.1 2354512 2355225 D identified by match to protein family HMM PF01569; PAP2 family protein 2354512..2355225 Escherichia coli SMS-3-5 6146186 YP_001744371.1 CDS spr NC_010498.1 2355637 2356203 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2355637..2356203 Escherichia coli SMS-3-5 6146829 YP_001744372.1 CDS EcSMS35_2325 NC_010498.1 2356384 2357940 D identified by match to protein family HMM PF00563; hypothetical protein 2356384..2357940 Escherichia coli SMS-3-5 6145387 YP_001744373.1 CDS EcSMS35_2326 NC_010498.1 2358022 2359836 D identified by match to protein family HMM PF00496; ABC transporter periplasmic solute-binding protein 2358022..2359836 Escherichia coli SMS-3-5 6146038 YP_001744374.1 CDS EcSMS35_2327 NC_010498.1 2359837 2360931 D identified by match to protein family HMM PF00528; ABC transporter permease 2359837..2360931 Escherichia coli SMS-3-5 6145337 YP_001744375.1 CDS EcSMS35_2328 NC_010498.1 2360931 2361956 D identified by match to protein family HMM PF00528; ABC transporter permease 2360931..2361956 Escherichia coli SMS-3-5 6145877 YP_001744376.1 CDS EcSMS35_2329 NC_010498.1 2361958 2363547 D identified by match to protein family HMM PF00005; match to protein family HMM PF08352; ABC transporter ATP-binding protein 2361958..2363547 Escherichia coli SMS-3-5 6144241 YP_001744377.1 CDS EcSMS35_2330 NC_010498.1 2363551 2363895 R hypothetical protein complement(2363551..2363895) Escherichia coli SMS-3-5 6144774 YP_001744378.1 CDS bcr NC_010498.1 2364229 2365419 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system complement(2364229..2365419) Escherichia coli SMS-3-5 6146856 YP_001744379.1 CDS rsuA NC_010498.1 2365447 2366142 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(2365447..2366142) Escherichia coli SMS-3-5 6142925 YP_001744380.1 CDS EcSMS35_2333 NC_010498.1 2366292 2368052 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851; putative helicase 2366292..2368052 Escherichia coli SMS-3-5 6145767 YP_001744381.1 CDS rplY NC_010498.1 2368177 2368461 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2368177..2368461 Escherichia coli SMS-3-5 6146303 YP_001744382.1 CDS ndpA NC_010498.1 2368600 2369607 R identified by match to protein family HMM PF04245; nucleoid-associated protein NdpA complement(2368600..2369607) Escherichia coli SMS-3-5 6144298 YP_001744383.1 CDS EcSMS35_2336 NC_010498.1 2369652 2369768 R identified by Glimmer3; putative; hypothetical protein complement(2369652..2369768) Escherichia coli SMS-3-5 6144894 YP_001744384.1 CDS EcSMS35_2337 NC_010498.1 2369789 2370016 D identified by match to protein family HMM PF07208; hypothetical protein 2369789..2370016 Escherichia coli SMS-3-5 6146859 YP_001744385.1 CDS EcSMS35_2338 NC_010498.1 2370036 2371796 D identified by match to protein family HMM PF00884; sulfatase family protein 2370036..2371796 Escherichia coli SMS-3-5 6142763 YP_001744386.1 CDS narP NC_010498.1 2374961 2375608 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2374961..2375608 Escherichia coli SMS-3-5 6146200 YP_001744387.1 CDS EcSMS35_2342 NC_010498.1 2375643 2376695 R identified by match to protein family HMM PF03918; cytochrome c-type biogenesis family protein complement(2375643..2376695) Escherichia coli SMS-3-5 6143936 YP_001744388.1 CDS dsbE NC_010498.1 2376692 2377249 R identified by match to protein family HMM PF00578; match to protein family HMM PF08534; match to protein family HMM TIGR00385; thiol:disulfide interchange protein DsbE complement(2376692..2377249) Escherichia coli SMS-3-5 6144617 YP_001744389.1 CDS ccmF NC_010498.1 2377246 2379189 R identified by match to protein family HMM PF01578; match to protein family HMM TIGR00353; cytochrome c-type biogenesis protein CcmF complement(2377246..2379189) Escherichia coli SMS-3-5 6143358 YP_001744390.1 CDS ccmE NC_010498.1 2379186 2379665 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(2379186..2379665) Escherichia coli SMS-3-5 6144082 YP_001744391.1 CDS ccmD NC_010498.1 2379662 2379871 R identified by match to protein family HMM PF04995; match to protein family HMM TIGR03141; heme exporter protein D complement(2379662..2379871) Escherichia coli SMS-3-5 6144187 YP_001744392.1 CDS ccmC NC_010498.1 2379868 2380605 R identified by match to protein family HMM PF01578; match to protein family HMM TIGR01191; heme exporter protein C complement(2379868..2380605) Escherichia coli SMS-3-5 6145940 YP_001744393.1 CDS ccmB NC_010498.1 2380647 2381309 R identified by match to protein family HMM PF03379; match to protein family HMM TIGR01190; heme exporter protein CcmB complement(2380647..2381309) Escherichia coli SMS-3-5 6147331 YP_001744394.1 CDS ccmA NC_010498.1 2381306 2381923 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(2381306..2381923) Escherichia coli SMS-3-5 6144836 YP_001744395.1 CDS napC NC_010498.1 2381942 2382544 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(2381942..2382544) Escherichia coli SMS-3-5 6146402 YP_001744396.1 CDS napB NC_010498.1 2382554 2383003 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(2382554..2383003) Escherichia coli SMS-3-5 6143208 YP_001744397.1 CDS napH NC_010498.1 2383000 2383863 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(2383000..2383863) Escherichia coli SMS-3-5 6145844 YP_001744398.1 CDS napG NC_010498.1 2383850 2384545 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(2383850..2384545) Escherichia coli SMS-3-5 6145340 YP_001744399.1 CDS napA NC_010498.1 2384552 2387038 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(2384552..2387038) Escherichia coli SMS-3-5 6144910 YP_001744400.1 CDS napD NC_010498.1 2387035 2387298 R identified by match to protein family HMM PF03927; assembly protein for periplasmic nitrate reductase complement(2387035..2387298) Escherichia coli SMS-3-5 6144105 YP_001744401.1 CDS napF NC_010498.1 2387288 2387782 R Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein complement(2387288..2387782) Escherichia coli SMS-3-5 6147267 YP_001744402.1 CDS EcSMS35_2357 NC_010498.1 2387891 2388055 D identified by Glimmer3; putative; hypothetical protein 2387891..2388055 Escherichia coli SMS-3-5 6146850 YP_001744403.1 CDS eco NC_010498.1 2388190 2388678 D serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2388190..2388678 Escherichia coli SMS-3-5 6144336 YP_001744404.1 CDS mqo NC_010498.1 2388828 2390474 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2388828..2390474) Escherichia coli SMS-3-5 6143924 YP_001744405.1 CDS EcSMS35_2360 NC_010498.1 2390692 2392335 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component complement(2390692..2392335) Escherichia coli SMS-3-5 6143511 YP_001744406.1 CDS alkB NC_010498.1 2392411 2393061 R identified by match to protein family HMM PF03171; match to protein family HMM TIGR00568; alkylated DNA repair protein AlkB complement(2392411..2393061) Escherichia coli SMS-3-5 6142981 YP_001744407.1 CDS ada NC_010498.1 2393061 2394125 R identified by match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589; regulatory protein Ada complement(2393061..2394125) Escherichia coli SMS-3-5 6146437 YP_001744408.1 CDS apbE NC_010498.1 2394199 2395254 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(2394199..2395254) Escherichia coli SMS-3-5 6143331 YP_001744409.1 CDS ompC NC_010498.1 2395366 2396460 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(2395366..2396460) Escherichia coli SMS-3-5 6145314 YP_001744410.1 CDS yojN NC_010498.1 2397199 2399871 D identified by match to protein family HMM PF01627; match to protein family HMM PF02518; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2397199..2399871 Escherichia coli SMS-3-5 6145116 YP_001744411.1 CDS rcsB NC_010498.1 2399888 2400538 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2399888..2400538 Escherichia coli SMS-3-5 6143263 YP_001744412.1 CDS rcsC NC_010498.1 2400624 2403473 R identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518; hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(2400624..2403473) Escherichia coli SMS-3-5 6146456 YP_001744413.1 CDS atoS NC_010498.1 2403640 2405466 D with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2403640..2405466 Escherichia coli SMS-3-5 6144061 YP_001744414.1 CDS atoC NC_010498.1 2405463 2406848 D with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2405463..2406848 Escherichia coli SMS-3-5 6144692 YP_001744415.1 CDS pcaI NC_010498.1 2407044 2407706 D identified by match to protein family HMM PF01144; match to protein family HMM TIGR02429; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2407044..2407706 Escherichia coli SMS-3-5 6145386 YP_001744416.1 CDS EcSMS35_2371 NC_010498.1 2407706 2408356 D identified by match to protein family HMM PF01144; match to protein family HMM TIGR02428; 3-oxoacid CoA-transferase, B subunit 2407706..2408356 Escherichia coli SMS-3-5 6146048 YP_001744417.1 CDS EcSMS35_2372 NC_010498.1 2408353 2409675 D identified by match to protein family HMM PF02667; match to protein family HMM TIGR00366; putative short chain fatty acid transporter 2408353..2409675 Escherichia coli SMS-3-5 6146244 YP_001744418.1 CDS atoB NC_010498.1 2409706 2410890 D identified by match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; acetyl-CoA acetyltransferase 2409706..2410890 Escherichia coli SMS-3-5 6146927 YP_001744419.1 CDS EcSMS35_2374 NC_010498.1 2410964 2411740 R hypothetical protein complement(2410964..2411740) Escherichia coli SMS-3-5 6142649 YP_001744420.1 CDS EcSMS35_2375 NC_010498.1 2411745 2413394 R hypothetical protein complement(2411745..2413394) Escherichia coli SMS-3-5 6143347 YP_001744421.1 CDS EcSMS35_2376 NC_010498.1 2413395 2417909 R identified by match to protein family HMM PF01835; match to protein family HMM PF07703; alpha-2-macroglobulin family protein complement(2413395..2417909) Escherichia coli SMS-3-5 6144217 YP_001744422.1 CDS EcSMS35_2377 NC_010498.1 2417933 2418556 R identified by match to protein family HMM PF06672; hypothetical protein complement(2417933..2418556) Escherichia coli SMS-3-5 6145027 YP_001744423.1 CDS EcSMS35_2378 NC_010498.1 2418553 2420241 R hypothetical protein complement(2418553..2420241) Escherichia coli SMS-3-5 6145293 YP_001744424.1 CDS gyrA NC_010498.1 2420390 2423017 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2420390..2423017) Escherichia coli SMS-3-5 6147048 YP_001744425.1 CDS EcSMS35_2380 NC_010498.1 2423517 2424719 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein complement(2423517..2424719) Escherichia coli SMS-3-5 6146157 YP_001744426.1 CDS EcSMS35_2381 NC_010498.1 2424732 2426060 R identified by match to protein family HMM PF07690; major facilitator transporter complement(2424732..2426060) Escherichia coli SMS-3-5 6143507 YP_001744427.1 CDS EcSMS35_2382 NC_010498.1 2426298 2426996 D identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 2426298..2426996 Escherichia coli SMS-3-5 6142639 YP_001744428.1 CDS ubiG NC_010498.1 2427074 2427796 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2427074..2427796 Escherichia coli SMS-3-5 6144354 YP_001744429.1 CDS EcSMS35_2384 NC_010498.1 2427935 2431699 R identified by match to protein family HMM PF02415; match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01376; match to protein family HMM TIGR01414; match to protein family HMM TIGR02601; adhesin complement(2427935..2431699) Escherichia coli SMS-3-5 6144679 YP_001744430.1 CDS nrdA NC_010498.1 2432395 2434680 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2432395..2434680 Escherichia coli SMS-3-5 6144153 YP_001744431.1 CDS nrdB NC_010498.1 2434775 2435956 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2434775..2435956 Escherichia coli SMS-3-5 6146461 YP_001744432.1 CDS EcSMS35_2387 NC_010498.1 2435956 2436210 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2435956..2436210 Escherichia coli SMS-3-5 6146389 YP_001744433.1 CDS EcSMS35_2388 NC_010498.1 2436264 2436914 R identified by match to protein family HMM PF06293; hypothetical protein complement(2436264..2436914) Escherichia coli SMS-3-5 6147132 YP_001744434.1 CDS EcSMS35_2389 NC_010498.1 2436995 2438185 R identified by match to protein family HMM PF07690; major facilitator transporter complement(2436995..2438185) Escherichia coli SMS-3-5 6142736 YP_001744435.1 CDS EcSMS35_2390 NC_010498.1 2438337 2439236 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 2438337..2439236 Escherichia coli SMS-3-5 6142987 YP_001744436.1 CDS glpQ NC_010498.1 2439256 2440332 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2439256..2440332) Escherichia coli SMS-3-5 6144249 YP_001744437.1 CDS glpT NC_010498.1 2440337 2441695 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2440337..2441695) Escherichia coli SMS-3-5 6143971 YP_001744438.1 CDS glpA NC_010498.1 2441967 2443595 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2441967..2443595 Escherichia coli SMS-3-5 6144461 YP_001744439.1 CDS glpB NC_010498.1 2443585 2444844 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2443585..2444844 Escherichia coli SMS-3-5 6145888 YP_001744440.1 CDS glpC NC_010498.1 2444841 2446031 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2444841..2446031 Escherichia coli SMS-3-5 6145649 YP_001744441.1 CDS EcSMS35_2396 NC_010498.1 2446056 2446181 D identified by Glimmer3; putative; hypothetical protein 2446056..2446181 Escherichia coli SMS-3-5 6143175 YP_001744442.1 CDS EcSMS35_2397 NC_010498.1 2446224 2447183 D yfaD; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 2446224..2447183 Escherichia coli SMS-3-5 6144112 YP_001744443.1 CDS EcSMS35_2398 NC_010498.1 2447196 2447381 D hypothetical protein 2447196..2447381 Escherichia coli SMS-3-5 6144906 YP_001744444.1 CDS EcSMS35_2399 NC_010498.1 2447422 2448225 R identified by match to protein family HMM PF03328; putative aldolase complement(2447422..2448225) Escherichia coli SMS-3-5 6145227 YP_001744445.1 CDS EcSMS35_2400 NC_010498.1 2448243 2449532 R identified by match to protein family HMM PF07690; major facilitator transporter complement(2448243..2449532) Escherichia coli SMS-3-5 6145913 YP_001744446.1 CDS EcSMS35_2401 NC_010498.1 2449589 2450794 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein complement(2449589..2450794) Escherichia coli SMS-3-5 6146910 YP_001744447.1 CDS EcSMS35_2402 NC_010498.1 2450809 2451591 R identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator complement(2450809..2451591) Escherichia coli SMS-3-5 6142680 YP_001744448.1 CDS EcSMS35_2403 NC_010498.1 2451811 2453013 R identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR00200; competence damage-inducible protein A complement(2451811..2453013) Escherichia coli SMS-3-5 6143052 YP_001744449.1 CDS EcSMS35_2404 NC_010498.1 2453113 2453655 R identified by match to protein family HMM PF07437; outer membrane protein, YfaZ complement(2453113..2453655) Escherichia coli SMS-3-5 6144182 YP_001744450.1 CDS EcSMS35_2405 NC_010498.1 2453996 2454358 D identified by match to protein family HMM PF00293; NUDIX family hydrolase 2453996..2454358 Escherichia coli SMS-3-5 6144873 YP_001744451.1 CDS EcSMS35_2406 NC_010498.1 2454397 2454999 R identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein complement(2454397..2454999) Escherichia coli SMS-3-5 6143798 YP_001744452.1 CDS arnB NC_010498.1 2455289 2456446 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2455289..2456446 Escherichia coli SMS-3-5 6143266 YP_001744453.1 CDS arnC NC_010498.1 2456450 2457418 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2456450..2457418 Escherichia coli SMS-3-5 6147504 YP_001744454.1 CDS arnA NC_010498.1 2457418 2459400 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2457418..2459400 Escherichia coli SMS-3-5 6142809 YP_001744455.1 CDS EcSMS35_2410 NC_010498.1 2459397 2460287 D identified by match to protein family HMM PF01522; polysaccharide deacetylase domain-containing protein 2459397..2460287 Escherichia coli SMS-3-5 6147061 YP_001744456.1 CDS arnT NC_010498.1 2460287 2461939 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2460287..2461939 Escherichia coli SMS-3-5 6146714 YP_001744457.1 CDS EcSMS35_2412 NC_010498.1 2461936 2462271 D identified by match to protein family HMM PF00893; SMR family multidrug efflux pump 2461936..2462271 Escherichia coli SMS-3-5 6146006 YP_001744458.1 CDS EcSMS35_2414 NC_010498.1 2462271 2462657 D hypothetical protein 2462271..2462657 Escherichia coli SMS-3-5 6145047 YP_001744459.1 CDS pmrD NC_010498.1 2462651 2462917 R polymyxin B resistance protein pmrD complement(2462651..2462917) Escherichia coli SMS-3-5 6143928 YP_001744460.1 CDS menE NC_010498.1 2463027 2464382 R identified by match to protein family HMM PF00501; match to protein family HMM TIGR01923; O-succinylbenzoic acid--CoA ligase complement(2463027..2464382) Escherichia coli SMS-3-5 6144551 YP_001744461.1 CDS menC NC_010498.1 2464379 2465341 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(2464379..2465341) Escherichia coli SMS-3-5 6146060 YP_001744462.1 CDS menB NC_010498.1 2465341 2466198 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2465341..2466198) Escherichia coli SMS-3-5 6146754 YP_001744463.1 CDS EcSMS35_2418 NC_010498.1 2466213 2466971 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB complement(2466213..2466971) Escherichia coli SMS-3-5 6144667 YP_001744464.1 CDS menD NC_010498.1 2466968 2468638 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2466968..2468638) Escherichia coli SMS-3-5 6144159 YP_001744465.1 CDS menF NC_010498.1 2468727 2470022 R identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543; isochorismate synthase, menaquinone-specific complement(2468727..2470022) Escherichia coli SMS-3-5 6142620 YP_001744466.1 CDS EcSMS35_2421 NC_010498.1 2470101 2470406 R identified by match to protein family HMM PF05957; hypothetical protein complement(2470101..2470406) Escherichia coli SMS-3-5 6144624 YP_001744467.1 CDS EcSMS35_2422 NC_010498.1 2470461 2470922 R identified by match to protein family HMM PF00583; hypothetical protein complement(2470461..2470922) Escherichia coli SMS-3-5 6146181 YP_001744468.1 CDS rnz NC_010498.1 2470969 2471904 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2470969..2471904 Escherichia coli SMS-3-5 6143119 YP_001744469.1 CDS EcSMS35_2423 NC_010498.1 2471894 2472067 R identified by Glimmer3; putative; hypothetical protein complement(2471894..2472067) Escherichia coli SMS-3-5 6144919 YP_001744470.1 CDS EcSMS35_2426 NC_010498.1 2473374 2475140 R identified by match to protein family HMM PF00092; von Willebrand factor type A domain-containing protein complement(2473374..2475140) Escherichia coli SMS-3-5 6147313 YP_001744471.1 CDS EcSMS35_2427 NC_010498.1 2475130 2475264 R identified by Glimmer3; putative; hypothetical protein complement(2475130..2475264) Escherichia coli SMS-3-5 6145271 YP_001744472.1 CDS EcSMS35_2428 NC_010498.1 2475432 2476253 D yfbL; identified by match to protein family HMM PF04389; M28 family peptidase 2475432..2476253 Escherichia coli SMS-3-5 6145883 YP_001744473.1 CDS EcSMS35_2429 NC_010498.1 2476353 2476856 D identified by match to protein family HMM PF08974; hypothetical protein 2476353..2476856 Escherichia coli SMS-3-5 6145648 YP_001744474.1 CDS nuoN NC_010498.1 2476924 2478381 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2476924..2478381) Escherichia coli SMS-3-5 6144505 YP_001744475.1 CDS nuoM NC_010498.1 2478388 2479917 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2478388..2479917) Escherichia coli SMS-3-5 6142650 YP_001744476.1 CDS nuoL NC_010498.1 2480081 2481916 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2480081..2481916) Escherichia coli SMS-3-5 6143146 YP_001744477.1 CDS nuoK NC_010498.1 2481919 2482221 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2481919..2482221) Escherichia coli SMS-3-5 6146625 YP_001744478.1 CDS nuoJ NC_010498.1 2482218 2482772 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2482218..2482772) Escherichia coli SMS-3-5 6145384 YP_001744479.1 CDS nuoI NC_010498.1 2482784 2483326 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2482784..2483326) Escherichia coli SMS-3-5 6146061 YP_001744480.1 CDS nuoH NC_010498.1 2483341 2484318 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2483341..2484318) Escherichia coli SMS-3-5 6145258 YP_001744481.1 CDS nuoG NC_010498.1 2484315 2487041 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2484315..2487041) Escherichia coli SMS-3-5 6145987 YP_001744482.1 CDS nuoF NC_010498.1 2487094 2488431 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(2487094..2488431) Escherichia coli SMS-3-5 6144296 YP_001744483.1 CDS nuoE NC_010498.1 2488428 2488928 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2488428..2488928) Escherichia coli SMS-3-5 6144362 YP_001744484.1 CDS nuoC NC_010498.1 2488931 2490733 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2488931..2490733) Escherichia coli SMS-3-5 6143204 YP_001744485.1 CDS nuoB NC_010498.1 2490827 2491489 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2490827..2491489) Escherichia coli SMS-3-5 6146380 YP_001744486.1 CDS nuoA NC_010498.1 2491505 2491948 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2491505..2491948) Escherichia coli SMS-3-5 6145247 YP_001744487.1 CDS EcSMS35_2443 NC_010498.1 2491920 2492051 D identified by Glimmer3; putative; hypothetical protein 2491920..2492051 Escherichia coli SMS-3-5 6145944 YP_001744488.1 CDS lrhA NC_010498.1 2492578 2493516 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator LrhA complement(2492578..2493516) Escherichia coli SMS-3-5 6145962 YP_001744489.1 CDS EcSMS35_2445 NC_010498.1 2494436 2495653 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2494436..2495653 Escherichia coli SMS-3-5 6144190 YP_001744490.1 CDS yfbR NC_010498.1 2495737 2496336 D identified by match to protein family HMM PF01966; hypothetical protein 2495737..2496336 Escherichia coli SMS-3-5 6145724 YP_001744491.1 CDS EcSMS35_2447 NC_010498.1 2496395 2498227 R identified by match to protein family HMM PF02080; match to protein family HMM PF03600; match to protein family HMM PF06808; putative transporter complement(2496395..2498227) Escherichia coli SMS-3-5 6146432 YP_001744492.1 CDS yfbT NC_010498.1 2498314 2498964 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; putative phosphatase complement(2498314..2498964) Escherichia coli SMS-3-5 6144433 YP_001744493.1 CDS EcSMS35_2449 NC_010498.1 2498975 2499469 R identified by match to protein family HMM PF03887; hypothetical protein complement(2498975..2499469) Escherichia coli SMS-3-5 6145084 YP_001744494.1 CDS EcSMS35_2450 NC_010498.1 2499552 2500007 R identified by match to protein family HMM PF04217; hypothetical protein complement(2499552..2500007) Escherichia coli SMS-3-5 6143784 YP_001744495.1 CDS EcSMS35_2451 NC_010498.1 2500076 2500207 R hypothetical protein complement(2500076..2500207) Escherichia coli SMS-3-5 6144453 YP_001744496.1 CDS ackA NC_010498.1 2500345 2501547 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2500345..2501547 Escherichia coli SMS-3-5 6147152 YP_001744497.1 CDS pta NC_010498.1 2501622 2503766 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2501622..2503766 Escherichia coli SMS-3-5 6142964 YP_001744498.1 CDS EcSMS35_2454 NC_010498.1 2503935 2505476 D identified by match to protein family HMM PF03606; hypothetical protein 2503935..2505476 Escherichia coli SMS-3-5 6145162 YP_001744499.1 CDS EcSMS35_2455 NC_010498.1 2505509 2506051 R identified by match to protein family HMM PF00293; NUDIX family hydrolase complement(2505509..2506051) Escherichia coli SMS-3-5 6145800 YP_001744500.1 CDS EcSMS35_2456 NC_010498.1 2506109 2506660 R identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase complement(2506109..2506660) Escherichia coli SMS-3-5 6144706 YP_001744501.1 CDS EcSMS35_2457 NC_010498.1 2506716 2507360 R identified by match to protein family HMM PF02798; glutathione S-transferase domain-containing protein complement(2506716..2507360) Escherichia coli SMS-3-5 6144945 YP_001744502.1 CDS EcSMS35_2458 NC_010498.1 2507497 2508144 D yfcG; identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathione S-transferase 2507497..2508144 Escherichia coli SMS-3-5 6143450 YP_001744503.1 CDS folX NC_010498.1 2508201 2508563 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2508201..2508563 Escherichia coli SMS-3-5 6144170 YP_001744504.1 CDS EcSMS35_2460 NC_010498.1 2508584 2509477 D identified by match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM PF08338; match to protein family HMM TIGR01777; NAD-binding domain-containing protein 2508584..2509477 Escherichia coli SMS-3-5 6142625 YP_001744505.1 CDS EcSMS35_2461 NC_010498.1 2509525 2510427 R yfcI; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein complement(2509525..2510427) Escherichia coli SMS-3-5 6142737 YP_001744506.1 CDS hisP NC_010498.1 2510624 2511397 R identified by match to protein family HMM PF00005; histidine/lysine/arginine/ornithine transporter subunit complement(2510624..2511397) Escherichia coli SMS-3-5 6146125 YP_001744507.1 CDS hisM NC_010498.1 2511405 2512121 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; histidine ABC transporter permease HisM complement(2511405..2512121) Escherichia coli SMS-3-5 6146813 YP_001744508.1 CDS hisQ NC_010498.1 2512118 2512804 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; histidine ABC transporter permease HisQ complement(2512118..2512804) Escherichia coli SMS-3-5 6143785 YP_001744509.1 CDS hisJ NC_010498.1 2512894 2513676 R identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; histidine ABC transporter periplasmic histidine-binding protein complement(2512894..2513676) Escherichia coli SMS-3-5 6144459 YP_001744510.1 CDS argT NC_010498.1 2513897 2514679 R identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; lysine-arginine-ornithine-binding periplasmic protein complement(2513897..2514679) Escherichia coli SMS-3-5 6144601 YP_001744511.1 CDS ubiX NC_010498.1 2514945 2515514 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2514945..2515514) Escherichia coli SMS-3-5 6142618 YP_001744512.1 CDS purF NC_010498.1 2515609 2517126 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2515609..2517126) Escherichia coli SMS-3-5 6142717 YP_001744513.1 CDS cvpA NC_010498.1 2517163 2517651 R membrane protein required for colicin V production; colicin V production protein complement(2517163..2517651) Escherichia coli SMS-3-5 6143403 YP_001744514.1 CDS EcSMS35_2470 NC_010498.1 2517887 2518549 R identified by match to protein family HMM PF05036; hypothetical protein complement(2517887..2518549) Escherichia coli SMS-3-5 6145797 YP_001744515.1 CDS folC NC_010498.1 2518539 2519807 R identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2518539..2519807) Escherichia coli SMS-3-5 6145733 YP_001744516.1 CDS accD NC_010498.1 2519877 2520791 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2519877..2520791) Escherichia coli SMS-3-5 6147191 YP_001744517.1 CDS EcSMS35_2473 NC_010498.1 2520947 2521606 R identified by match to protein family HMM PF09335; hypothetical protein complement(2520947..2521606) Escherichia coli SMS-3-5 6142761 YP_001744518.1 CDS truA NC_010498.1 2521689 2522501 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2521689..2522501) Escherichia coli SMS-3-5 6143589 YP_001744519.1 CDS EcSMS35_2475 NC_010498.1 2522501 2523514 R identified by match to protein family HMM PF01118; match to protein family HMM PF02774; putative semialdehyde dehydrogenase complement(2522501..2523514) Escherichia coli SMS-3-5 6144252 YP_001744520.1 CDS EcSMS35_2477 NC_010498.1 2523495 2523608 D identified by Glimmer3; putative; hypothetical protein 2523495..2523608 Escherichia coli SMS-3-5 6145156 YP_001744521.1 CDS pdxB NC_010498.1 2523580 2524716 R identified by match to protein family HMM PF00389; match to protein family HMM PF02826; erythronate-4-phosphate dehydrogenase complement(2523580..2524716) Escherichia coli SMS-3-5 6143872 YP_001744522.1 CDS flk NC_010498.1 2524815 2525810 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2524815..2525810 Escherichia coli SMS-3-5 6145659 YP_001744523.1 CDS EcSMS35_2478 NC_010498.1 2525807 2526985 R identified by match to protein family HMM PF07690; hypothetical protein complement(2525807..2526985) Escherichia coli SMS-3-5 6147466 YP_001744524.1 CDS fabB NC_010498.1 2527217 2528437 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I complement(2527217..2528437) Escherichia coli SMS-3-5 6146990 YP_001744525.1 CDS mnmC NC_010498.1 2528596 2530602 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2528596..2530602 Escherichia coli SMS-3-5 6143237 YP_001744526.1 CDS EcSMS35_2482 NC_010498.1 2530658 2530936 R identified by match to protein family HMM PF08891; hypothetical protein complement(2530658..2530936) Escherichia coli SMS-3-5 6146399 YP_001744527.1 CDS EcSMS35_2483 NC_010498.1 2530970 2531518 R identified by match to protein family HMM PF04315; hypothetical protein complement(2530970..2531518) Escherichia coli SMS-3-5 6146959 YP_001744528.1 CDS EcSMS35_2484 NC_010498.1 2531518 2532327 R identified by match to protein family HMM PF01925; hypothetical protein complement(2531518..2532327) Escherichia coli SMS-3-5 6145217 YP_001744529.1 CDS mepA NC_010498.1 2532327 2533151 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2532327..2533151) Escherichia coli SMS-3-5 6146071 YP_001744530.1 CDS aroC NC_010498.1 2533155 2534240 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2533155..2534240) Escherichia coli SMS-3-5 6144165 YP_001744531.1 CDS prmB NC_010498.1 2534275 2535207 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2534275..2535207) Escherichia coli SMS-3-5 6145124 YP_001744532.1 CDS EcSMS35_2488 NC_010498.1 2535373 2535924 D identified by match to protein family HMM PF01713; hypothetical protein 2535373..2535924 Escherichia coli SMS-3-5 6145515 YP_001744533.1 CDS EcSMS35_2489 NC_010498.1 2536010 2537368 D SMC domain-containing protein 2536010..2537368 Escherichia coli SMS-3-5 6147095 YP_001744534.1 CDS EcSMS35_2490 NC_010498.1 2537352 2538011 D hypothetical protein 2537352..2538011 Escherichia coli SMS-3-5 6143549 YP_001744535.1 CDS EcSMS35_2491 NC_010498.1 2538053 2538892 R yfcO; identified by similarity to GB:AAN81328.1; hypothetical protein complement(2538053..2538892) Escherichia coli SMS-3-5 6142870 YP_001744536.1 CDS EcSMS35_2492 NC_010498.1 2538894 2539418 R yfcP; identified by match to protein family HMM PF00419; putative minor fimbrial subunit complement(2538894..2539418) Escherichia coli SMS-3-5 6144413 YP_001744537.1 CDS EcSMS35_2493 NC_010498.1 2539415 2539864 R yfcQ; putative minor fimbrial protein complement(2539415..2539864) Escherichia coli SMS-3-5 6143747 YP_001744538.1 CDS EcSMS35_2494 NC_010498.1 2539882 2540373 R yfcR; identified by similarity to GB:AAV76235.1; fimbrial protein complement(2539882..2540373) Escherichia coli SMS-3-5 6143136 YP_001744539.1 CDS EcSMS35_2495 NC_010498.1 2540390 2541142 R yfcS; identified by match to protein family HMM PF00345; fimbrial chaperone protein complement(2540390..2541142) Escherichia coli SMS-3-5 6147403 YP_001744540.1 CDS EcSMS35_2496 NC_010498.1 2541162 2543810 R yfcU; identified by match to protein family HMM PF00577; fimbrial usher protein complement(2541162..2543810) Escherichia coli SMS-3-5 6144254 YP_001744541.1 CDS EcSMS35_2497 NC_010498.1 2543891 2544457 R yfcV; identified by similarity to GB:AAC64152.1; match to protein family HMM PF00419; fimbrial protein complement(2543891..2544457) Escherichia coli SMS-3-5 6143805 YP_001744542.1 CDS sixA NC_010498.1 2545025 2545510 R identified by similarity to SP:P76502; match to protein family HMM PF00300; match to protein family HMM TIGR00249; phosphohistidine phosphatase complement(2545025..2545510) Escherichia coli SMS-3-5 6145332 YP_001744543.1 CDS EcSMS35_2499 NC_010498.1 2545487 2545639 D identified by Glimmer3; putative; hypothetical protein 2545487..2545639 Escherichia coli SMS-3-5 6146005 YP_001744544.1 CDS fadJ NC_010498.1 2545713 2547857 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2545713..2547857) Escherichia coli SMS-3-5 6146373 YP_001744545.1 CDS fadI NC_010498.1 2547857 2549167 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2547857..2549167) Escherichia coli SMS-3-5 6146720 YP_001744546.1 CDS EcSMS35_2502 NC_010498.1 2549348 2549632 R identified by match to protein family HMM PF04175; match to protein family HMM TIGR00743; hypothetical protein complement(2549348..2549632) Escherichia coli SMS-3-5 6142655 YP_001744547.1 CDS EcSMS35_2503 NC_010498.1 2550004 2551344 D identified by match to protein family HMM PF03349; long-chain fatty acid outer membrane transporter 2550004..2551344 Escherichia coli SMS-3-5 6143177 YP_001744548.1 CDS EcSMS35_2504 NC_010498.1 2551711 2552958 D identified by similarity to GB:AAP17747.1; hypothetical protein 2551711..2552958 Escherichia coli SMS-3-5 6147284 YP_001744549.1 CDS EcSMS35_2505 NC_010498.1 2553137 2553892 R identified by match to protein family HMM PF04333; VacJ family lipoprotein complement(2553137..2553892) Escherichia coli SMS-3-5 6146711 YP_001744550.1 CDS EcSMS35_2506 NC_010498.1 2553918 2554031 R hypothetical protein complement(2553918..2554031) Escherichia coli SMS-3-5 6145429 YP_001744551.1 CDS EcSMS35_2507 NC_010498.1 2554186 2555118 D hypothetical protein 2554186..2555118 Escherichia coli SMS-3-5 6144463 YP_001744552.1 CDS EcSMS35_2509 NC_010498.1 2555706 2556236 R identified by match to protein family HMM PF03938; putative outer membrane protein complement(2555706..2556236) Escherichia coli SMS-3-5 6143635 YP_001744553.1 CDS EcSMS35_2510 NC_010498.1 2556284 2564197 R identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; match to protein family HMM TIGR02601; outer membrane autotransporter complement(2556284..2564197) Escherichia coli SMS-3-5 6145756 YP_001744554.1 CDS EcSMS35_2511 NC_010498.1 2564222 2564842 R identified by match to protein family HMM PF00196; match to protein family HMM PF08281; LuxR family transcriptional regulator complement(2564222..2564842) Escherichia coli SMS-3-5 6143230 YP_001744555.1 CDS EcSMS35_2512 NC_010498.1 2565160 2565789 R identified by similarity to SP:P0ADH5; match to protein family HMM PF00589; type 1 fimbriae regulatory protein complement(2565160..2565789) Escherichia coli SMS-3-5 6144269 YP_001744556.1 CDS EcSMS35_2513 NC_010498.1 2566538 2567107 D identified by similarity to SP:P0ADH5; match to protein family HMM PF00589; type 1 fimbriae regulatory protein 2566538..2567107 Escherichia coli SMS-3-5 6143355 YP_001744557.1 CDS dsdC NC_010498.1 2567502 2568449 R regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC complement(2567502..2568449) Escherichia coli SMS-3-5 6143590 YP_001744558.1 CDS EcSMS35_2515 NC_010498.1 2568667 2570004 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2568667..2570004 Escherichia coli SMS-3-5 6145943 YP_001744559.1 CDS dsdA NC_010498.1 2570037 2571353 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 2570037..2571353 Escherichia coli SMS-3-5 6145252 YP_001744560.1 CDS emrY NC_010498.1 2571458 2572996 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; multidrug resistance protein Y complement(2571458..2572996) Escherichia coli SMS-3-5 6146019 YP_001744561.1 CDS emrK NC_010498.1 2572996 2574159 R identified by match to protein family HMM PF00529; match to protein family HMM TIGR00998; drug resistance MFS transporter, membrane fusion protein (MFP) subunit EmrK complement(2572996..2574159) Escherichia coli SMS-3-5 6147025 YP_001744562.1 CDS evgA NC_010498.1 2574575 2575189 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2574575..2575189 Escherichia coli SMS-3-5 6147099 YP_001744563.1 CDS evgS NC_010498.1 2575404 2578787 D identified by match to protein family HMM PF00072; match to protein family HMM PF00497; match to protein family HMM PF00512; match to protein family HMM PF01627; match to protein family HMM PF02518; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2575404..2578787 Escherichia coli SMS-3-5 6143045 YP_001744564.1 CDS EcSMS35_2521 NC_010498.1 2578843 2579988 R identified by match to protein family HMM PF02515; hypothetical protein complement(2578843..2579988) Escherichia coli SMS-3-5 6147487 YP_001744565.1 CDS EcSMS35_2522 NC_010498.1 2580062 2581006 R member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV complement(2580062..2581006) Escherichia coli SMS-3-5 6144808 YP_001744566.1 CDS EcSMS35_2523 NC_010498.1 2581075 2582769 R catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase complement(2581075..2582769) Escherichia coli SMS-3-5 6144288 YP_001744567.1 CDS frc NC_010498.1 2582823 2584073 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2582823..2584073) Escherichia coli SMS-3-5 6146854 YP_001744568.1 CDS EcSMS35_2525 NC_010498.1 2584585 2585208 R hypothetical protein complement(2584585..2585208) Escherichia coli SMS-3-5 6146198 YP_001744569.1 CDS EcSMS35_2526 NC_010498.1 2585437 2585562 R identified by Glimmer3; putative; hypothetical protein complement(2585437..2585562) Escherichia coli SMS-3-5 6143279 YP_001744570.1 CDS EcSMS35_2527 NC_010498.1 2585504 2585779 D putative lipoprotein 2585504..2585779 Escherichia coli SMS-3-5 6143942 YP_001744571.1 CDS EcSMS35_2528 NC_010498.1 2585856 2586098 R hypothetical protein complement(2585856..2586098) Escherichia coli SMS-3-5 6146106 YP_001744572.1 CDS EcSMS35_2529 NC_010498.1 2586451 2587371 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2586451..2587371 Escherichia coli SMS-3-5 6142691 YP_001744573.1 CDS EcSMS35_2530 NC_010498.1 2587682 2587798 D identified by Glimmer3; putative; hypothetical protein 2587682..2587798 Escherichia coli SMS-3-5 6144719 YP_001744574.1 CDS EcSMS35_2531 NC_010498.1 2587863 2589101 R identified by match to protein family HMM PF00155; aminotransferase complement(2587863..2589101) Escherichia coli SMS-3-5 6143181 YP_001744575.1 CDS EcSMS35_2532 NC_010498.1 2589496 2591175 D identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF06580; match to protein family HMM PF07694; sensor histidine kinase 2589496..2591175 Escherichia coli SMS-3-5 6142623 YP_001744576.1 CDS EcSMS35_2533 NC_010498.1 2591190 2591924 D identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 2591190..2591924 Escherichia coli SMS-3-5 6145684 YP_001744577.1 CDS EcSMS35_2534 NC_010498.1 2591937 2592794 D identified by match to protein family HMM PF00165; AraC family transcriptional regulator 2591937..2592794 Escherichia coli SMS-3-5 6145210 YP_001744578.1 CDS fryA NC_010498.1 2592797 2595292 R identified by match to protein family HMM PF00359; match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR00848; match to protein family HMM TIGR01417; multiphosphoryl transfer protein 1 complement(2592797..2595292) Escherichia coli SMS-3-5 6144861 YP_001744579.1 CDS EcSMS35_2536 NC_010498.1 2595317 2596354 R metalloprotein; exoaminopeptidase complement(2595317..2596354) Escherichia coli SMS-3-5 6143891 YP_001744580.1 CDS ypdF NC_010498.1 2596354 2597439 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(2596354..2597439) Escherichia coli SMS-3-5 6144040 YP_001744581.1 CDS fryC NC_010498.1 2597454 2598701 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR01427; PTS system, fructose-like, IIC component complement(2597454..2598701) Escherichia coli SMS-3-5 6142621 YP_001744582.1 CDS EcSMS35_2539 NC_010498.1 2598723 2599049 R identified by match to protein family HMM PF02379; match to protein family HMM TIGR00829; PTS system, fructose specific IIB subunit complement(2598723..2599049) Escherichia coli SMS-3-5 6145410 YP_001744583.1 CDS glk NC_010498.1 2599268 2600233 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2599268..2600233) Escherichia coli SMS-3-5 6146062 YP_001744584.1 CDS EcSMS35_2541 NC_010498.1 2600437 2601693 D identified by match to protein family HMM PF00654; hypothetical protein 2600437..2601693 Escherichia coli SMS-3-5 6146142 YP_001744585.1 CDS EcSMS35_2542 NC_010498.1 2601808 2602134 D hypothetical protein 2601808..2602134 Escherichia coli SMS-3-5 6146838 YP_001744586.1 CDS mntH NC_010498.1 2602202 2603440 R identified by match to protein family HMM PF01566; match to protein family HMM TIGR01197; manganese transport protein MntH complement(2602202..2603440) Escherichia coli SMS-3-5 6147533 YP_001744587.1 CDS nupC NC_010498.1 2603776 2604978 D identified by similarity to SP:P0AFF2; match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; nucleoside transporter NupC 2603776..2604978 Escherichia coli SMS-3-5 6143290 YP_001744588.1 CDS EcSMS35_2545 NC_010498.1 2605027 2607216 R identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM PF05231; diguanylate cyclase complement(2605027..2607216) Escherichia coli SMS-3-5 6142810 YP_001744589.1 CDS EcSMS35_2548 NC_010498.1 2607850 2608194 D hypothetical protein 2607850..2608194 Escherichia coli SMS-3-5 6143698 YP_001744590.1 CDS EcSMS35_2549 NC_010498.1 2608196 2608588 D identified by match to protein family HMM PF07037; hypothetical protein 2608196..2608588 Escherichia coli SMS-3-5 6146818 YP_001744591.1 CDS EcSMS35_2551 NC_010498.1 2609909 2610064 D identified by Glimmer3; putative; hypothetical protein 2609909..2610064 Escherichia coli SMS-3-5 6144761 YP_001744592.1 CDS gltX NC_010498.1 2610388 2611803 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2610388..2611803) Escherichia coli SMS-3-5 6144265 YP_001744593.1 CDS EcSMS35_2553 NC_010498.1 2611807 2611938 D identified by Glimmer3; putative; hypothetical protein 2611807..2611938 Escherichia coli SMS-3-5 6143757 YP_001744594.1 CDS xapR NC_010498.1 2612570 2613454 R identified by similarity to SP:P23841; match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional activator XapR complement(2612570..2613454) Escherichia coli SMS-3-5 6143678 YP_001744595.1 CDS EcSMS35_2559 NC_010498.1 2613496 2613654 R identified by similarity to GB:AAX66324.1; match to protein family HMM TIGR03510; hypothetical protein complement(2613496..2613654) Escherichia coli SMS-3-5 6147532 YP_001744596.1 CDS xapB NC_010498.1 2613707 2614963 R identified by similarity to SP:P45562; match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; xanthosine permease XapB complement(2613707..2614963) Escherichia coli SMS-3-5 6147042 YP_001744597.1 CDS xapA NC_010498.1 2615024 2615857 R catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase complement(2615024..2615857) Escherichia coli SMS-3-5 6146696 YP_001744598.1 CDS EcSMS35_2562 NC_010498.1 2616106 2616870 D yfeN; identified by match to protein family HMM PF07135; hypothetical protein 2616106..2616870 Escherichia coli SMS-3-5 6147219 YP_001744599.1 CDS EcSMS35_2563 NC_010498.1 2616908 2617834 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(2616908..2617834) Escherichia coli SMS-3-5 6142774 YP_001744600.1 CDS EcSMS35_2565 NC_010498.1 2617924 2618922 D bile acid/Na+ symporter family protein 2617924..2618922 Escherichia coli SMS-3-5 6143329 YP_001744601.1 CDS EcSMS35_2564 NC_010498.1 2618919 2619137 R hypothetical protein complement(2618919..2619137) Escherichia coli SMS-3-5 6144958 YP_001744602.1 CDS ligA NC_010498.1 2619139 2621154 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2619139..2621154) Escherichia coli SMS-3-5 6145611 YP_001744603.1 CDS zipA NC_010498.1 2621225 2622223 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2621225..2622223) Escherichia coli SMS-3-5 6144615 YP_001744604.1 CDS cysZ NC_010498.1 2622453 2623214 D putative role in sulfur assimilation; putative sulfate transport protein CysZ 2622453..2623214 Escherichia coli SMS-3-5 6143896 YP_001744605.1 CDS cysK NC_010498.1 2623399 2624370 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2623399..2624370 Escherichia coli SMS-3-5 6143429 YP_001744606.1 CDS ptsH NC_010498.1 2624754 2625011 D identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2624754..2625011 Escherichia coli SMS-3-5 6142728 YP_001744607.1 CDS ptsI NC_010498.1 2625056 2626783 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2625056..2626783 Escherichia coli SMS-3-5 6144360 YP_001744608.1 CDS crr NC_010498.1 2626824 2627333 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2626824..2627333 Escherichia coli SMS-3-5 6145194 YP_001744609.1 CDS EcSMS35_2573 NC_010498.1 2627452 2628780 D identified by match to protein family HMM PF01609; IS4 transposase 2627452..2628780 Escherichia coli SMS-3-5 6146049 YP_001744610.1 CDS pdxK NC_010498.1 2628814 2629665 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2628814..2629665) Escherichia coli SMS-3-5 6146587 YP_001744611.1 CDS EcSMS35_2575 NC_010498.1 2629770 2630138 D hypothetical protein 2629770..2630138 Escherichia coli SMS-3-5 6147139 YP_001744612.1 CDS cysM NC_010498.1 2630141 2631052 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2630141..2631052) Escherichia coli SMS-3-5 6143180 YP_001744613.1 CDS cysA NC_010498.1 2631186 2632283 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR00968; sulfate/thiosulfate transporter subunit complement(2631186..2632283) Escherichia coli SMS-3-5 6143535 YP_001744614.1 CDS cysW NC_010498.1 2632273 2633148 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit complement(2632273..2633148) Escherichia coli SMS-3-5 6144062 YP_001744615.1 CDS cysT NC_010498.1 2633148 2633981 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02139; sulfate/thiosulfate transporter subunit complement(2633148..2633981) Escherichia coli SMS-3-5 6145473 YP_001744616.1 CDS cysP NC_010498.1 2633981 2634997 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971; thiosulfate transporter subunit complement(2633981..2634997) Escherichia coli SMS-3-5 6146029 YP_001744617.1 CDS ucpA NC_010498.1 2635155 2635946 R identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659; short chain dehydrogenase complement(2635155..2635946) Escherichia coli SMS-3-5 6143999 YP_001744618.1 CDS EcSMS35_2582 NC_010498.1 2636075 2636932 R identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator complement(2636075..2636932) Escherichia coli SMS-3-5 6143089 YP_001744619.1 CDS murQ NC_010498.1 2637096 2637992 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2637096..2637992 Escherichia coli SMS-3-5 6142827 YP_001744620.1 CDS murP NC_010498.1 2637996 2639420 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2637996..2639420 Escherichia coli SMS-3-5 6146997 YP_001744621.1 CDS EcSMS35_2585 NC_010498.1 2639425 2640726 D identified by match to protein family HMM PF00144; hypothetical protein 2639425..2640726 Escherichia coli SMS-3-5 6145811 YP_001744622.1 CDS EcSMS35_2586 NC_010498.1 2640784 2641683 R identified by match to protein family HMM PF04261; match to protein family HMM TIGR01413; dyp-type peroxidase family protein complement(2640784..2641683) Escherichia coli SMS-3-5 6145326 YP_001744623.1 CDS EcSMS35_2587 NC_010498.1 2641779 2642354 R identified by match to protein family HMM PF06572; hypothetical protein complement(2641779..2642354) Escherichia coli SMS-3-5 6144770 YP_001744624.1 CDS EcSMS35_2588 NC_010498.1 2642415 2642762 R putative inner membrane protein YfeZ complement(2642415..2642762) Escherichia coli SMS-3-5 6144407 YP_001744625.1 CDS EcSMS35_2589 NC_010498.1 2642851 2643276 R identified by match to protein family HMM PF00583; putative acetyltransferase complement(2642851..2643276) Escherichia coli SMS-3-5 6143109 YP_001744626.1 CDS amiA NC_010498.1 2643490 2644359 D identified by similarity to SP:P36548; match to protein family HMM PF01520; match to protein family HMM TIGR01409; N-acetylmuramoyl-l-alanine amidase I 2643490..2644359 Escherichia coli SMS-3-5 6147362 YP_001744627.1 CDS hemF NC_010498.1 2644363 2645262 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2644363..2645262 Escherichia coli SMS-3-5 6142944 YP_001744628.1 CDS EcSMS35_2592 NC_010498.1 2645268 2646320 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(2645268..2646320) Escherichia coli SMS-3-5 6143807 YP_001744629.1 CDS EcSMS35_2593 NC_010498.1 2646366 2646866 R identified by match to protein family HMM PF00936; putative ethanolamine utilization protein EutK complement(2646366..2646866) Escherichia coli SMS-3-5 6144464 YP_001744630.1 CDS EcSMS35_2594 NC_010498.1 2646879 2647538 R identified by match to protein family HMM PF00936; putative ethanolamine utilization protein EutL complement(2646879..2647538) Escherichia coli SMS-3-5 6145150 YP_001744631.1 CDS eutC NC_010498.1 2647548 2648435 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(2647548..2648435) Escherichia coli SMS-3-5 6145237 YP_001744632.1 CDS eutB NC_010498.1 2648456 2649817 R identified by match to protein family HMM PF06751; ethanolamine ammonia-lyase, large subunit complement(2648456..2649817) Escherichia coli SMS-3-5 6147405 YP_001744633.1 CDS eutA NC_010498.1 2649829 2651232 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(2649829..2651232) Escherichia coli SMS-3-5 6142998 YP_001744634.1 CDS eutH NC_010498.1 2651229 2652455 R identified by match to protein family HMM PF04346; ethanolamine utilization protein EutH complement(2651229..2652455) Escherichia coli SMS-3-5 6144711 YP_001744635.1 CDS eutG NC_010498.1 2652625 2653812 R identified by match to protein family HMM PF00465; ethanolamine utilization protein EutG complement(2652625..2653812) Escherichia coli SMS-3-5 6142888 YP_001744636.1 CDS eutJ NC_010498.1 2653802 2654638 R identified by match to protein family HMM TIGR02529; ethanolamine utilization protein EutJ complement(2653802..2654638) Escherichia coli SMS-3-5 6145437 YP_001744637.1 CDS eutE NC_010498.1 2654649 2656052 R identified by match to protein family HMM PF00171; ethanolamine utilization protein EutE complement(2654649..2656052) Escherichia coli SMS-3-5 6146809 YP_001744638.1 CDS eutN NC_010498.1 2656064 2656351 R identified by match to protein family HMM PF03319; ethanolamine utilization protein complement(2656064..2656351) Escherichia coli SMS-3-5 6145426 YP_001744639.1 CDS eutM NC_010498.1 2656458 2656751 R identified by match to protein family HMM PF00936; ethanolamine utilization protein EutM complement(2656458..2656751) Escherichia coli SMS-3-5 6147167 YP_001744640.1 CDS eutD NC_010498.1 2656790 2657806 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(2656790..2657806) Escherichia coli SMS-3-5 6144063 YP_001744641.1 CDS eutT NC_010498.1 2657803 2658606 R identified by match to protein family HMM PF01923; ethanolamine utilization cobalamin adenosyltransferase complement(2657803..2658606) Escherichia coli SMS-3-5 6145755 YP_001744642.1 CDS EcSMS35_2606 NC_010498.1 2658603 2659304 R identified by match to protein family HMM PF05899; match to protein family HMM PF06249; ethanolamine utilization protein EutQ complement(2658603..2659304) Escherichia coli SMS-3-5 6146503 YP_001744643.1 CDS eutP NC_010498.1 2659279 2659758 R identified by match to protein family HMM TIGR02528; ethanolamine utilization protein, EutP complement(2659279..2659758) Escherichia coli SMS-3-5 6147188 YP_001744644.1 CDS EcSMS35_2608 NC_010498.1 2659771 2660106 R identified by match to protein family HMM PF00936; ethanolamine utilization protein EutS complement(2659771..2660106) Escherichia coli SMS-3-5 6142889 YP_001744645.1 CDS maeB NC_010498.1 2660399 2662678 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2660399..2662678) Escherichia coli SMS-3-5 6143585 YP_001744646.1 CDS tal1 NC_010498.1 2662967 2663917 D identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874; transaldolase A 2662967..2663917 Escherichia coli SMS-3-5 6143909 YP_001744647.1 CDS tktB NC_010498.1 2663937 2665940 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2663937..2665940 Escherichia coli SMS-3-5 6142658 YP_001744648.1 CDS EcSMS35_2612 NC_010498.1 2666043 2667086 R identified by match to protein family HMM PF06674; hypothetical protein complement(2666043..2667086) Escherichia coli SMS-3-5 6143833 YP_001744649.1 CDS EcSMS35_2613 NC_010498.1 2667212 2667787 R identified by match to protein family HMM PF00293; match to protein family HMM TIGR00052; NUDIX family hydrolase complement(2667212..2667787) Escherichia coli SMS-3-5 6144911 YP_001744650.1 CDS aegA1 NC_010498.1 2667855 2669834 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit complement(2667855..2669834) Escherichia coli SMS-3-5 6145157 YP_001744651.1 CDS narQ NC_010498.1 2670040 2671740 D identified by similarity to SP:P27896; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730; nitrate/nitrite sensor protein NarQ 2670040..2671740 Escherichia coli SMS-3-5 6145645 YP_001744652.1 CDS acrD NC_010498.1 2671904 2675017 D identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915; aminoglycoside/multidrug efflux system 2671904..2675017 Escherichia coli SMS-3-5 6146452 YP_001744653.1 CDS EcSMS35_2617 NC_010498.1 2675556 2675912 D identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; hypothetical protein 2675556..2675912 Escherichia coli SMS-3-5 6142764 YP_001744654.1 CDS dapE NC_010498.1 2675916 2677043 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2675916..2677043 Escherichia coli SMS-3-5 6147444 YP_001744655.1 CDS EcSMS35_2619 NC_010498.1 2677071 2677271 D hypothetical protein 2677071..2677271 Escherichia coli SMS-3-5 6143197 YP_001744656.1 CDS EcSMS35_2620 NC_010498.1 2677352 2678050 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH complement(2677352..2678050) Escherichia coli SMS-3-5 6144441 YP_001744657.1 CDS EcSMS35_2621 NC_010498.1 2678124 2680139 R identified by match to protein family HMM PF05127; hypothetical protein complement(2678124..2680139) Escherichia coli SMS-3-5 6143209 YP_001744658.1 CDS EcSMS35_2622 NC_010498.1 2680154 2681017 R identified by match to protein family HMM PF04228; hypothetical protein complement(2680154..2681017) Escherichia coli SMS-3-5 6142666 YP_001744659.1 CDS purC NC_010498.1 2681185 2681898 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2681185..2681898) Escherichia coli SMS-3-5 6143217 YP_001744660.1 CDS EcSMS35_2624 NC_010498.1 2682111 2683145 R identified by match to protein family HMM PF06804; lipoprotein complement(2682111..2683145) Escherichia coli SMS-3-5 6142685 YP_001744661.1 CDS dapA NC_010498.1 2683162 2684040 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2683162..2684040) Escherichia coli SMS-3-5 6146774 YP_001744662.1 CDS gcvR NC_010498.1 2684186 2684758 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2684186..2684758 Escherichia coli SMS-3-5 6146255 YP_001744663.1 CDS bcp NC_010498.1 2684758 2685228 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2684758..2685228 Escherichia coli SMS-3-5 6144181 YP_001744664.1 CDS hyfA NC_010498.1 2685481 2686098 D identified by match to protein family HMM PF00037; hydrogenase-4 component A 2685481..2686098 Escherichia coli SMS-3-5 6145803 YP_001744665.1 CDS hyfB NC_010498.1 2686098 2688116 D identified by similarity to SP:P23482; match to protein family HMM PF00361; hydrogenase 4 subunit B 2686098..2688116 Escherichia coli SMS-3-5 6142811 YP_001744666.1 CDS hyfC NC_010498.1 2688127 2689074 D identified by match to protein family HMM PF00146; hydrogenase-4 component C 2688127..2689074 Escherichia coli SMS-3-5 6144484 YP_001744667.1 CDS hyfD NC_010498.1 2689091 2690530 D identified by similarity to SP:P77416; match to protein family HMM PF00361; hydrogenase 4 subunit D 2689091..2690530 Escherichia coli SMS-3-5 6147422 YP_001744668.1 CDS hyfE NC_010498.1 2690542 2691192 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2690542..2691192 Escherichia coli SMS-3-5 6146868 YP_001744669.1 CDS EcSMS35_2633 NC_010498.1 2691197 2692777 D identified by match to protein family HMM PF00361; hydrogenase 4 subunit F 2691197..2692777 Escherichia coli SMS-3-5 6143090 YP_001744670.1 CDS EcSMS35_2634 NC_010498.1 2692767 2694482 D identified by match to protein family HMM PF00329; match to protein family HMM PF00346; hydrogenase-4, G subunit 2692767..2694482 Escherichia coli SMS-3-5 6147381 YP_001744671.1 CDS EcSMS35_2635 NC_010498.1 2694492 2695037 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2694492..2695037 Escherichia coli SMS-3-5 6144886 YP_001744672.1 CDS EcSMS35_2636 NC_010498.1 2695034 2695792 D identified by match to protein family HMM PF01058; hydrogenase-4, I subunit 2695034..2695792 Escherichia coli SMS-3-5 6144210 YP_001744673.1 CDS EcSMS35_2637 NC_010498.1 2695785 2696198 D identified by match to protein family HMM PF07450; formate hydrogenlyase maturation protein HycH 2695785..2696198 Escherichia coli SMS-3-5 6146898 YP_001744674.1 CDS hyfR NC_010498.1 2696228 2698240 D identified by similarity to SP:P71229; match to protein family HMM PF00158; match to protein family HMM PF01590; match to protein family HMM PF02954; hydrogenase-4 transcriptional regulator 2696228..2698240 Escherichia coli SMS-3-5 6145879 YP_001744675.1 CDS focB NC_010498.1 2698262 2699110 D inner membrane protein presumed to act as a formate transporter; member of the hyf operon; putative formate transporter 2698262..2699110 Escherichia coli SMS-3-5 6143074 YP_001744676.1 CDS EcSMS35_2640 NC_010498.1 2699147 2700208 R identified by match to protein family HMM PF01594; PerM family permease complement(2699147..2700208) Escherichia coli SMS-3-5 6147344 YP_001744677.1 CDS EcSMS35_2641 NC_010498.1 2700421 2701884 D identified by match to protein family HMM PF01435; M48 family peptidase 2700421..2701884 Escherichia coli SMS-3-5 6143586 YP_001744678.1 CDS arsC1 NC_010498.1 2701905 2702264 D identified by match to protein family HMM PF03960; match to protein family HMM TIGR00014; arsenate reductase 2701905..2702264 Escherichia coli SMS-3-5 6144544 YP_001744679.1 CDS hda NC_010498.1 2702370 2703116 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(2702370..2703116) Escherichia coli SMS-3-5 6142724 YP_001744680.1 CDS uraA NC_010498.1 2703166 2704455 R identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil transporter complement(2703166..2704455) Escherichia coli SMS-3-5 6143393 YP_001744681.1 CDS upp NC_010498.1 2704541 2705167 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2704541..2705167) Escherichia coli SMS-3-5 6146611 YP_001744682.1 CDS EcSMS35_2646 NC_010498.1 2705144 2705278 D identified by Glimmer3; putative; hypothetical protein 2705144..2705278 Escherichia coli SMS-3-5 6147323 YP_001744683.1 CDS purM NC_010498.1 2705492 2706529 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2705492..2706529 Escherichia coli SMS-3-5 6144428 YP_001744684.1 CDS purN NC_010498.1 2706529 2707167 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2706529..2707167 Escherichia coli SMS-3-5 6144896 YP_001744685.1 CDS ppk NC_010498.1 2707339 2709405 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2707339..2709405 Escherichia coli SMS-3-5 6143260 YP_001744686.1 CDS ppx NC_010498.1 2709410 2710951 D identified by match to protein family HMM PF02541; exopolyphosphatase 2709410..2710951 Escherichia coli SMS-3-5 6143834 YP_001744687.1 CDS EcSMS35_2651 NC_010498.1 2710990 2713233 R yfgF; identified by match to protein family HMM PF00563; match to protein family HMM PF05231; putative cytochrome C-type biogenesis protein complement(2710990..2713233) Escherichia coli SMS-3-5 6146975 YP_001744688.1 CDS EcSMS35_2652 NC_010498.1 2713415 2713567 R hypothetical protein complement(2713415..2713567) Escherichia coli SMS-3-5 6146272 YP_001744689.1 CDS EcSMS35_2653 NC_010498.1 2713585 2713776 D hypothetical protein 2713585..2713776 Escherichia coli SMS-3-5 6145039 YP_001744690.1 CDS EcSMS35_2654 NC_010498.1 2714090 2714605 D identified by match to protein family HMM PF05433; surface antigen family protein 2714090..2714605 Escherichia coli SMS-3-5 6145541 YP_001744691.1 CDS EcSMS35_2655 NC_010498.1 2714621 2715160 D hypothetical protein 2714621..2715160 Escherichia coli SMS-3-5 6143315 YP_001744692.1 CDS guaA NC_010498.1 2715255 2716832 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2715255..2716832) Escherichia coli SMS-3-5 6146677 YP_001744693.1 CDS guaB NC_010498.1 2716901 2718436 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2716901..2718436) Escherichia coli SMS-3-5 6142770 YP_001744694.1 CDS xseA NC_010498.1 2718529 2719896 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2718529..2719896 Escherichia coli SMS-3-5 6143308 YP_001744695.1 CDS EcSMS35_2659 NC_010498.1 2719950 2728025 R identified by match to protein family HMM PF05688; match to protein family HMM PF05689; RatA-like protein complement(2719950..2728025) Escherichia coli SMS-3-5 6144015 YP_001744696.1 CDS EcSMS35_2660 NC_010498.1 2728135 2729127 R putative adhesin complement(2728135..2729127) Escherichia coli SMS-3-5 6144501 YP_001744697.1 CDS EcSMS35_2661 NC_010498.1 2729183 2731357 R putative adhesin complement(2729183..2731357) Escherichia coli SMS-3-5 6145103 YP_001744698.1 CDS EcSMS35_2662 NC_010498.1 2731567 2731782 R identified by similarity to GB:AAP83330.1; match to protein family HMM PF07191; hypothetical protein complement(2731567..2731782) Escherichia coli SMS-3-5 6145720 YP_001744699.1 CDS engA NC_010498.1 2731845 2733317 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2731845..2733317) Escherichia coli SMS-3-5 6144825 YP_001744700.1 CDS EcSMS35_2664 NC_010498.1 2733435 2734613 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(2733435..2734613) Escherichia coli SMS-3-5 6145451 YP_001744701.1 CDS EcSMS35_2665 NC_010498.1 2734624 2735244 R hypothetical protein complement(2734624..2735244) Escherichia coli SMS-3-5 6145799 YP_001744702.1 CDS hisS NC_010498.1 2735262 2736536 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2735262..2736536) Escherichia coli SMS-3-5 6146367 YP_001744703.1 CDS ispG NC_010498.1 2736647 2737765 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2736647..2737765) Escherichia coli SMS-3-5 6146301 YP_001744704.1 CDS EcSMS35_2668 NC_010498.1 2737792 2738802 R identified by match to protein family HMM PF01381; cytoskeletal protein RodZ complement(2737792..2738802) Escherichia coli SMS-3-5 6147030 YP_001744705.1 CDS EcSMS35_2669 NC_010498.1 2739087 2740241 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(2739087..2740241) Escherichia coli SMS-3-5 6147379 YP_001744706.1 CDS ndk NC_010498.1 2740391 2740822 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2740391..2740822) Escherichia coli SMS-3-5 6143100 YP_001744707.1 CDS pbpC NC_010498.1 2740971 2743283 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(2740971..2743283) Escherichia coli SMS-3-5 6144527 YP_001744708.1 CDS EcSMS35_2672 NC_010498.1 2743284 2748242 R identified by match to protein family HMM PF01835; match to protein family HMM PF07703; alpha-2-macroglobulin domain-containing protein complement(2743284..2748242) Escherichia coli SMS-3-5 6147448 YP_001744709.1 CDS sseA NC_010498.1 2748449 2749294 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2748449..2749294 Escherichia coli SMS-3-5 6146374 YP_001744710.1 CDS sseB NC_010498.1 2749791 2750567 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2749791..2750567) Escherichia coli SMS-3-5 6146934 YP_001744711.1 CDS pepB NC_010498.1 2750709 2751992 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B complement(2750709..2751992) Escherichia coli SMS-3-5 6147186 YP_001744712.1 CDS iscX NC_010498.1 2752051 2752251 R identified by match to protein family HMM PF04384; match to protein family HMM TIGR03412; hypothetical protein complement(2752051..2752251) Escherichia coli SMS-3-5 6145449 YP_001744713.1 CDS fdx NC_010498.1 2752263 2752598 R identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007; ferredoxin, 2Fe-2S type, ISC system complement(2752263..2752598) Escherichia coli SMS-3-5 6147194 YP_001744714.1 CDS hscA NC_010498.1 2752600 2754450 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2752600..2754450) Escherichia coli SMS-3-5 6145255 YP_001744715.1 CDS hscB NC_010498.1 2754467 2754982 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2754467..2754982) Escherichia coli SMS-3-5 6145142 YP_001744716.1 CDS EcSMS35_2680 NC_010498.1 2754990 2755106 R identified by Glimmer3; putative; hypothetical protein complement(2754990..2755106) Escherichia coli SMS-3-5 6145656 YP_001744717.1 CDS iscA NC_010498.1 2755078 2755401 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2755078..2755401) Escherichia coli SMS-3-5 6143746 YP_001744718.1 CDS iscU NC_010498.1 2755418 2755804 R identified by match to protein family HMM PF01592; match to protein family HMM TIGR01999; scaffold protein complement(2755418..2755804) Escherichia coli SMS-3-5 6145674 YP_001744719.1 CDS iscS NC_010498.1 2755832 2757046 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2755832..2757046) Escherichia coli SMS-3-5 6147223 YP_001744720.1 CDS iscR NC_010498.1 2757158 2757646 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2757158..2757646) Escherichia coli SMS-3-5 6146663 YP_001744721.1 CDS EcSMS35_2685 NC_010498.1 2757917 2758657 R identified by match to protein family HMM PF00588; match to protein family HMM TIGR00050; RNA methyltransferase complement(2757917..2758657) Escherichia coli SMS-3-5 6143345 YP_001744722.1 CDS suhB NC_010498.1 2758776 2759579 D identified by match to protein family HMM PF00459; inositol monophosphatase 2758776..2759579 Escherichia coli SMS-3-5 6142975 YP_001744723.1 CDS EcSMS35_2687 NC_010498.1 2759724 2760578 D hypothetical protein 2759724..2760578 Escherichia coli SMS-3-5 6147087 YP_001744724.1 CDS csiE NC_010498.1 2760769 2762049 D identified by match to protein family HMM PF00874; stationary phase inducible protein CsiE 2760769..2762049 Escherichia coli SMS-3-5 6146517 YP_001744725.1 CDS hcaT NC_010498.1 2762041 2763180 R putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter complement(2762041..2763180) Escherichia coli SMS-3-5 6142858 YP_001744726.1 CDS hcaR NC_010498.1 2763340 2764233 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(2763340..2764233) Escherichia coli SMS-3-5 6143497 YP_001744727.1 CDS hcaE NC_010498.1 2764366 2765727 D identified by match to protein family HMM PF00355; match to protein family HMM PF00848; 3-phenylpropionate dioxygenase alpha subunit 2764366..2765727 Escherichia coli SMS-3-5 6145470 YP_001744728.1 CDS hcaF NC_010498.1 2765724 2766242 D identified by match to protein family HMM PF00866; 3-phenylpropionate dioxygenase subunit beta 2765724..2766242 Escherichia coli SMS-3-5 6144346 YP_001744729.1 CDS hcaC NC_010498.1 2766242 2766562 D identified by match to protein family HMM PF00355; 3-phenylpropionate dioxygenase ferredoxin subunit 2766242..2766562 Escherichia coli SMS-3-5 6143859 YP_001744730.1 CDS hcaB NC_010498.1 2766559 2767371 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2766559..2767371 Escherichia coli SMS-3-5 6143216 YP_001744731.1 CDS hcaD NC_010498.1 2767381 2768583 D identified by match to protein family HMM PF00070; match to protein family HMM PF07992; phenylpropionate dioxygenase ferredoxin reductase subunit 2767381..2768583 Escherichia coli SMS-3-5 6142684 YP_001744732.1 CDS EcSMS35_2696 NC_010498.1 2768680 2769102 D identified by match to protein family HMM PF07681; putative inner membrane protein YphA 2768680..2769102 Escherichia coli SMS-3-5 6142789 YP_001744733.1 CDS EcSMS35_2697 NC_010498.1 2769150 2770022 R identified by match to protein family HMM PF01263; aldose 1-epimerase family protein complement(2769150..2770022) Escherichia coli SMS-3-5 6147249 YP_001744734.1 CDS EcSMS35_2698 NC_010498.1 2770034 2771128 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase complement(2770034..2771128) Escherichia coli SMS-3-5 6146545 YP_001744735.1 CDS EcSMS35_2699 NC_010498.1 2771161 2772159 R identified by match to protein family HMM PF02653; putative sugar ABC transporter permease complement(2771161..2772159) Escherichia coli SMS-3-5 6145582 YP_001744736.1 CDS EcSMS35_2700 NC_010498.1 2772184 2773695 R identified by match to protein family HMM PF00005; putative sugar ABC transporter ATP-binding protein complement(2772184..2773695) Escherichia coli SMS-3-5 6144918 YP_001744737.1 CDS EcSMS35_2701 NC_010498.1 2773718 2774701 R identified by match to protein family HMM PF00532; putative sugar ABC transporter periplasmic sugar-binding protein complement(2773718..2774701) Escherichia coli SMS-3-5 6142879 YP_001744738.1 CDS EcSMS35_2702 NC_010498.1 2774798 2778079 R identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR repeat-containing protein complement(2774798..2778079) Escherichia coli SMS-3-5 6147137 YP_001744739.1 CDS EcSMS35_2703 NC_010498.1 2778197 2779390 D identified by match to protein family HMM PF00480; ROK family protein 2778197..2779390 Escherichia coli SMS-3-5 6146442 YP_001744740.1 CDS glyA NC_010498.1 2779454 2780707 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2779454..2780707) Escherichia coli SMS-3-5 6145789 YP_001744741.1 CDS hmp NC_010498.1 2781035 2782225 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2781035..2782225 Escherichia coli SMS-3-5 6145110 YP_001744742.1 CDS glnB NC_010498.1 2782270 2782608 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(2782270..2782608) Escherichia coli SMS-3-5 6144435 YP_001744743.1 CDS EcSMS35_2707 NC_010498.1 2782669 2784003 R identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728; sigma-54 dependent response regulator complement(2782669..2784003) Escherichia coli SMS-3-5 6143768 YP_001744744.1 CDS EcSMS35_2708 NC_010498.1 2783993 2784706 R hypothetical protein complement(2783993..2784706) Escherichia coli SMS-3-5 6145257 YP_001744745.1 CDS EcSMS35_2709 NC_010498.1 2784871 2786298 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase complement(2784871..2786298) Escherichia coli SMS-3-5 6144786 YP_001744746.1 CDS purL NC_010498.1 2786875 2790762 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2786875..2790762) Escherichia coli SMS-3-5 6144273 YP_001744747.1 CDS EcSMS35_2712 NC_010498.1 2791022 2792578 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2791022..2792578 Escherichia coli SMS-3-5 6146433 YP_001744748.1 CDS tadA NC_010498.1 2792575 2793078 R identified by match to protein family HMM PF00383; tRNA-specific adenosine deaminase complement(2792575..2793078) Escherichia coli SMS-3-5 6145612 YP_001744749.1 CDS yhfB NC_010498.1 2793136 2793771 R identified by match to protein family HMM TIGR01545; hypothetical protein complement(2793136..2793771) Escherichia coli SMS-3-5 6147127 YP_001744750.1 CDS EcSMS35_2714 NC_010498.1 2793980 2794828 D identified by match to protein family HMM PF01380; match to protein family HMM PF01418; putative DNA-binding transcriptional regulator 2793980..2794828 Escherichia coli SMS-3-5 6143923 YP_001744751.1 CDS EcSMS35_2715 NC_010498.1 2794860 2795144 D 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein 2794860..2795144 Escherichia coli SMS-3-5 6144361 YP_001744752.1 CDS acpS NC_010498.1 2795839 2796219 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2795839..2796219) Escherichia coli SMS-3-5 6147434 YP_001744753.1 CDS pdxJ NC_010498.1 2796219 2796950 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2796219..2796950) Escherichia coli SMS-3-5 6143419 YP_001744754.1 CDS recO NC_010498.1 2796962 2797690 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2796962..2797690) Escherichia coli SMS-3-5 6146614 YP_001744755.1 CDS era NC_010498.1 2797702 2798607 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2797702..2798607) Escherichia coli SMS-3-5 6145200 YP_001744756.1 CDS rnc NC_010498.1 2798604 2799284 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2798604..2799284) Escherichia coli SMS-3-5 6145691 YP_001744757.1 CDS lepB NC_010498.1 2799557 2800531 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2799557..2800531) Escherichia coli SMS-3-5 6145076 YP_001744758.1 CDS lepA NC_010498.1 2800547 2802346 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2800547..2802346) Escherichia coli SMS-3-5 6144231 YP_001744759.1 CDS rseC NC_010498.1 2802543 2803022 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2802543..2803022) Escherichia coli SMS-3-5 6143803 YP_001744760.1 CDS rseB NC_010498.1 2803019 2803975 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2803019..2803975) Escherichia coli SMS-3-5 6143538 YP_001744761.1 CDS rseA NC_010498.1 2803975 2804625 R identified by match to protein family HMM PF03872; match to protein family HMM PF03873; anti-RNA polymerase sigma factor SigE complement(2803975..2804625) Escherichia coli SMS-3-5 6142841 YP_001744762.1 CDS rpoE NC_010498.1 2804658 2805233 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2804658..2805233) Escherichia coli SMS-3-5 6147106 YP_001744763.1 CDS nadB NC_010498.1 2805641 2807263 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2805641..2807263 Escherichia coli SMS-3-5 6146416 YP_001744764.1 CDS EcSMS35_2727 NC_010498.1 2807248 2807985 R identified by match to protein family HMM PF05175; putative methyltransferase complement(2807248..2807985) Escherichia coli SMS-3-5 6145556 YP_001744765.1 CDS srmB NC_010498.1 2808117 2809451 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2808117..2809451 Escherichia coli SMS-3-5 6143858 YP_001744766.1 CDS EcSMS35_2730 NC_010498.1 2809484 2810365 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(2809484..2810365) Escherichia coli SMS-3-5 6143560 YP_001744767.1 CDS EcSMS35_2731 NC_010498.1 2810468 2811055 D identified by match to protein family HMM PF01810; neutral amino-acid efflux protein 2810468..2811055 Escherichia coli SMS-3-5 6143193 YP_001744768.1 CDS grcA NC_010498.1 2811110 2811493 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2811110..2811493) Escherichia coli SMS-3-5 6144185 YP_001744769.1 CDS ung NC_010498.1 2811798 2812487 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2811798..2812487 Escherichia coli SMS-3-5 6144842 YP_001744770.1 CDS EcSMS35_2734 NC_010498.1 2812535 2813572 R identified by match to protein family HMM PF00588; match to protein family HMM PF08032; putative methyltransferase complement(2812535..2813572) Escherichia coli SMS-3-5 6143255 YP_001744771.1 CDS EcSMS35_2735 NC_010498.1 2813779 2814198 D identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 2 2813779..2814198 Escherichia coli SMS-3-5 6142824 YP_001744772.1 CDS EcSMS35_2736 NC_010498.1 2814267 2814965 D identified by match to protein family HMM PF03942; DTW domain-containing protein 2814267..2814965 Escherichia coli SMS-3-5 6144402 YP_001744773.1 CDS EcSMS35_2737 NC_010498.1 2814997 2817657 D identified by match to protein family HMM PF00583; match to protein family HMM PF02629; CoA-binding domain/acetyltransferase domain-containing protein 2814997..2817657 Escherichia coli SMS-3-5 6143910 YP_001744774.1 CDS pssA NC_010498.1 2817771 2819126 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2817771..2819126 Escherichia coli SMS-3-5 6145485 YP_001744775.1 CDS EcSMS35_2740 NC_010498.1 2819223 2819495 D hypothetical protein 2819223..2819495 Escherichia coli SMS-3-5 6144956 YP_001744776.1 CDS kgtP NC_010498.1 2819492 2820790 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; alpha-ketoglutarate transporter complement(2819492..2820790) Escherichia coli SMS-3-5 6146863 YP_001744777.1 CDS clpB NC_010498.1 2826569 2829142 R identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR03346; protein disaggregation chaperone complement(2826569..2829142) Escherichia coli SMS-3-5 6143716 YP_001744778.1 CDS EcSMS35_2747 NC_010498.1 2829272 2830003 R yfiH; identified by match to protein family HMM PF02578; match to protein family HMM TIGR00726; hypothetical protein complement(2829272..2830003) Escherichia coli SMS-3-5 6143277 YP_001744779.1 CDS rluD NC_010498.1 2830000 2830980 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(2830000..2830980) Escherichia coli SMS-3-5 6143501 YP_001744780.1 CDS EcSMS35_2749 NC_010498.1 2831115 2831852 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2831115..2831852 Escherichia coli SMS-3-5 6143003 YP_001744781.1 CDS EcSMS35_2750 NC_010498.1 2832123 2832464 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2832123..2832464 Escherichia coli SMS-3-5 6147118 YP_001744782.1 CDS pheA NC_010498.1 2832714 2833874 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2832714..2833874 Escherichia coli SMS-3-5 6146584 YP_001744783.1 CDS tyrA NC_010498.1 2833917 2835038 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(2833917..2835038) Escherichia coli SMS-3-5 6145812 YP_001744784.1 CDS aroF NC_010498.1 2835049 2836119 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(2835049..2836119) Escherichia coli SMS-3-5 6143986 YP_001744785.1 CDS EcSMS35_2754 NC_010498.1 2836329 2836694 D hypothetical protein 2836329..2836694 Escherichia coli SMS-3-5 6147251 YP_001744786.1 CDS EcSMS35_2755 NC_010498.1 2836844 2837362 D hypothetical protein 2836844..2837362 Escherichia coli SMS-3-5 6144915 YP_001744787.1 CDS EcSMS35_2756 NC_010498.1 2837355 2838578 D identified by match to protein family HMM PF00672; match to protein family HMM PF00990; match to protein family HMM TIGR00254; hypothetical protein 2837355..2838578 Escherichia coli SMS-3-5 6146815 YP_001744788.1 CDS EcSMS35_2757 NC_010498.1 2838594 2839076 D identified by match to protein family HMM PF00691; putative outer membrane lipoprotein 2838594..2839076 Escherichia coli SMS-3-5 6147492 YP_001744789.1 CDS rplS NC_010498.1 2839153 2839500 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(2839153..2839500) Escherichia coli SMS-3-5 6145734 YP_001744790.1 CDS trmD NC_010498.1 2839542 2840309 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(2839542..2840309) Escherichia coli SMS-3-5 6146498 YP_001744791.1 CDS rimM NC_010498.1 2840340 2840891 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(2840340..2840891) Escherichia coli SMS-3-5 6144660 YP_001744792.1 CDS rpsP NC_010498.1 2840907 2841155 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(2840907..2841155) Escherichia coli SMS-3-5 6145407 YP_001744793.1 CDS ffh NC_010498.1 2841292 2842653 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(2841292..2842653) Escherichia coli SMS-3-5 6146674 YP_001744794.1 CDS EcSMS35_2763 NC_010498.1 2842745 2843611 D identified by match to protein family HMM PF01578; putative cytochrome C assembly protein 2842745..2843611 Escherichia coli SMS-3-5 6143338 YP_001744795.1 CDS EcSMS35_2764 NC_010498.1 2843656 2844918 D identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hypothetical protein 2843656..2844918 Escherichia coli SMS-3-5 6145375 YP_001744796.1 CDS EcSMS35_2765 NC_010498.1 2845042 2845647 D hypothetical protein 2845042..2845647 Escherichia coli SMS-3-5 6146179 YP_001744797.1 CDS grpE NC_010498.1 2845682 2846272 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2845682..2846272) Escherichia coli SMS-3-5 6146040 YP_001744798.1 CDS ppnK NC_010498.1 2846395 2847273 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2846395..2847273 Escherichia coli SMS-3-5 6145396 YP_001744799.1 CDS recN NC_010498.1 2847359 2849020 D identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; recombination and repair protein 2847359..2849020 Escherichia coli SMS-3-5 6144042 YP_001744800.1 CDS EcSMS35_2769 NC_010498.1 2849169 2849510 D identified by match to protein family HMM PF04355; hypothetical protein 2849169..2849510 Escherichia coli SMS-3-5 6142634 YP_001744801.1 CDS EcSMS35_2770 NC_010498.1 2849572 2849862 R identified by match to protein family HMM PF03658; hypothetical protein complement(2849572..2849862) Escherichia coli SMS-3-5 6144422 YP_001744802.1 CDS EcSMS35_2771 NC_010498.1 2849852 2850328 R identified by match to protein family HMM PF03364; hypothetical protein complement(2849852..2850328) Escherichia coli SMS-3-5 6145421 YP_001744803.1 CDS smpB NC_010498.1 2850460 2850942 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2850460..2850942 Escherichia coli SMS-3-5 6147300 YP_001744804.1 CDS EcSMS35_2773 NC_010498.1 2851680 2856377 R identified by Glimmer3; putative; hypothetical protein complement(2851680..2856377) Escherichia coli SMS-3-5 6143753 YP_001744805.1 CDS EcSMS35_2774 NC_010498.1 2856313 2856432 R identified by Glimmer3; putative; hypothetical protein complement(2856313..2856432) Escherichia coli SMS-3-5 6144013 YP_001744806.1 CDS EcSMS35_2775 NC_010498.1 2857184 2857933 R identified by Glimmer3; putative; hypothetical protein complement(2857184..2857933) Escherichia coli SMS-3-5 6145523 YP_001744807.1 CDS EcSMS35_2778 NC_010498.1 2860012 2862264 D identified by match to protein family HMM PF00128; match to protein family HMM PF02806; alpha amylase family protein 2860012..2862264 Escherichia coli SMS-3-5 6143706 YP_001744808.1 CDS EcSMS35_2779 NC_010498.1 2862601 2863578 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2862601..2863578 Escherichia coli SMS-3-5 6145404 YP_001744809.1 CDS EcSMS35_2780 NC_010498.1 2863598 2864866 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2863598..2864866 Escherichia coli SMS-3-5 6146911 YP_001744810.1 CDS gabD NC_010498.1 2864889 2866337 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2864889..2866337 Escherichia coli SMS-3-5 6146446 YP_001744811.1 CDS gabT2 NC_010498.1 2866351 2867631 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2866351..2867631 Escherichia coli SMS-3-5 6143779 YP_001744812.1 CDS gabP NC_010498.1 2867868 2869268 D identified by match to protein family HMM PF00324; match to protein family HMM TIGR01773; gamma-aminobutyrate transporter 2867868..2869268 Escherichia coli SMS-3-5 6143172 YP_001744813.1 CDS csiR NC_010498.1 2869289 2869951 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2869289..2869951 Escherichia coli SMS-3-5 6144834 YP_001744814.1 CDS EcSMS35_2785 NC_010498.1 2869952 2870401 R identified by match to protein family HMM PF01476; match to protein family HMM PF04972; LysM domain/BON superfamily protein complement(2869952..2870401) Escherichia coli SMS-3-5 6147483 YP_001744815.1 CDS EcSMS35_2786 NC_010498.1 2870485 2870643 R identified by match to protein family HMM PF01679; hypothetical protein complement(2870485..2870643) Escherichia coli SMS-3-5 6145334 YP_001744816.1 CDS EcSMS35_2787 NC_010498.1 2870826 2871125 D identified by match to protein family HMM PF01022; ArsR family transcriptional regulator 2870826..2871125 Escherichia coli SMS-3-5 6145830 YP_001744817.1 CDS EcSMS35_2788 NC_010498.1 2871135 2871659 D putative inner membrane protein 2871135..2871659 Escherichia coli SMS-3-5 6145329 YP_001744818.1 CDS stpA NC_010498.1 2871706 2872110 R identified by match to protein family HMM PF00816; DNA binding protein, nucleoid-associated complement(2871706..2872110) Escherichia coli SMS-3-5 6145858 YP_001744819.1 CDS EcSMS35_2790 NC_010498.1 2872778 2873227 D identified by match to protein family HMM PF06610; hypothetical protein 2872778..2873227 Escherichia coli SMS-3-5 6143752 YP_001744820.1 CDS EcSMS35_2791 NC_010498.1 2873264 2873608 R hypothetical protein complement(2873264..2873608) Escherichia coli SMS-3-5 6144860 YP_001744821.1 CDS EcSMS35_2792 NC_010498.1 2873760 2874089 D identified by match to protein family HMM PF05957; hypothetical protein 2873760..2874089 Escherichia coli SMS-3-5 6142600 YP_001744822.1 CDS EcSMS35_2793 NC_010498.1 2874146 2875480 R identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator complement(2874146..2875480) Escherichia coli SMS-3-5 6143066 YP_001744823.1 CDS EcSMS35_2794 NC_010498.1 2875568 2875999 D identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; carboxymuconolactone decarboxylase family protein 2875568..2875999 Escherichia coli SMS-3-5 6145824 YP_001744824.1 CDS nrdH NC_010498.1 2876208 2876453 D identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin-like protein 2876208..2876453 Escherichia coli SMS-3-5 6145850 YP_001744825.1 CDS nrdI NC_010498.1 2876450 2876860 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2876450..2876860 Escherichia coli SMS-3-5 6146523 YP_001744826.1 CDS nrdE NC_010498.1 2876833 2878977 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2876833..2878977 Escherichia coli SMS-3-5 6147500 YP_001744827.1 CDS nrdF NC_010498.1 2878987 2879946 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2878987..2879946 Escherichia coli SMS-3-5 6142946 YP_001744828.1 CDS proV NC_010498.1 2880302 2881504 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2880302..2881504 Escherichia coli SMS-3-5 6143336 YP_001744829.1 CDS proW NC_010498.1 2881497 2882561 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2881497..2882561 Escherichia coli SMS-3-5 6143762 YP_001744830.1 CDS proX NC_010498.1 2882619 2883611 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2882619..2883611 Escherichia coli SMS-3-5 6144425 YP_001744831.1 CDS EcSMS35_2802 NC_010498.1 2883664 2883810 D identified by Glimmer3; putative; hypothetical protein 2883664..2883810 Escherichia coli SMS-3-5 6146141 YP_001744832.1 CDS EcSMS35_2803 NC_010498.1 2883803 2884987 D identified by match to protein family HMM PF07690; major facilitator family transporter 2883803..2884987 Escherichia coli SMS-3-5 6146823 YP_001744833.1 CDS EcSMS35_2804 NC_010498.1 2885156 2885848 D identified by match to protein family HMM PF03591; branched chain amino acid ABC transporter 2885156..2885848 Escherichia coli SMS-3-5 6147146 YP_001744834.1 CDS EcSMS35_2805 NC_010498.1 2885838 2886173 D hypothetical protein 2885838..2886173 Escherichia coli SMS-3-5 6144427 YP_001744835.1 CDS mprA NC_010498.1 2886264 2886794 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2886264..2886794 Escherichia coli SMS-3-5 6146553 YP_001744836.1 CDS emrA NC_010498.1 2886921 2888093 D identified by match to protein family HMM PF00529; match to protein family HMM TIGR00998; multidrug resistance protein A 2886921..2888093 Escherichia coli SMS-3-5 6145823 YP_001744837.1 CDS emrB NC_010498.1 2888110 2889648 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; multidrug resistance protein B 2888110..2889648 Escherichia coli SMS-3-5 6146915 YP_001744838.1 CDS luxS NC_010498.1 2889712 2890227 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(2889712..2890227) Escherichia coli SMS-3-5 6146283 YP_001744839.1 CDS gshA NC_010498.1 2890377 2891933 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(2890377..2891933) Escherichia coli SMS-3-5 6143033 YP_001744840.1 CDS EcSMS35_2811 NC_010498.1 2892006 2892434 R hypothetical protein complement(2892006..2892434) Escherichia coli SMS-3-5 6147443 YP_001744841.1 CDS EcSMS35_2812 NC_010498.1 2892431 2892997 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(2892431..2892997) Escherichia coli SMS-3-5 6145529 YP_001744842.1 CDS csrA NC_010498.1 2894185 2894370 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(2894185..2894370) Escherichia coli SMS-3-5 6143707 YP_001744843.1 CDS EcSMS35_2819 NC_010498.1 2894480 2894596 D identified by Glimmer3; putative; hypothetical protein 2894480..2894596 Escherichia coli SMS-3-5 6147206 YP_001744844.1 CDS alaS NC_010498.1 2894605 2897235 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(2894605..2897235) Escherichia coli SMS-3-5 6145390 YP_001744845.1 CDS recX NC_010498.1 2897364 2897864 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2897364..2897864) Escherichia coli SMS-3-5 6146808 YP_001744846.1 CDS recA NC_010498.1 2897933 2898994 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(2897933..2898994) Escherichia coli SMS-3-5 6146393 YP_001744847.1 CDS EcSMS35_2823 NC_010498.1 2899074 2899571 R identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199; competence damage-inducible protein A complement(2899074..2899571) Escherichia coli SMS-3-5 6147440 YP_001744848.1 CDS mltB NC_010498.1 2899716 2900801 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(2899716..2900801) Escherichia coli SMS-3-5 6144782 YP_001744849.1 CDS srlA NC_010498.1 2901058 2901621 D identified by match to protein family HMM PF03608; match to protein family HMM TIGR00821; PTS system, glucitol/sorbitol-specific, IIC component 2901058..2901621 Escherichia coli SMS-3-5 6144312 YP_001744850.1 CDS srlE NC_010498.1 2901618 2902577 D identified by match to protein family HMM PF03612; match to protein family HMM PF07663; match to protein family HMM TIGR00825; PTS system, glucitol/sorbitol-specific, IIB component 2901618..2902577 Escherichia coli SMS-3-5 6145871 YP_001744851.1 CDS srlB NC_010498.1 2902588 2902959 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2902588..2902959 Escherichia coli SMS-3-5 6145838 YP_001744852.1 CDS srlD NC_010498.1 2902963 2903742 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2902963..2903742 Escherichia coli SMS-3-5 6145325 YP_001744853.1 CDS gutM NC_010498.1 2903848 2904207 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2903848..2904207 Escherichia coli SMS-3-5 6146403 YP_001744854.1 CDS srlR NC_010498.1 2904274 2905047 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2904274..2905047 Escherichia coli SMS-3-5 6147447 YP_001744855.1 CDS gutQ NC_010498.1 2905040 2906005 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2905040..2906005 Escherichia coli SMS-3-5 6144460 YP_001744856.1 CDS norR NC_010498.1 2906002 2907516 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator complement(2906002..2907516) Escherichia coli SMS-3-5 6144446 YP_001744857.1 CDS norV NC_010498.1 2907703 2909142 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2907703..2909142 Escherichia coli SMS-3-5 6143778 YP_001744858.1 CDS norW NC_010498.1 2909139 2910272 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2909139..2910272 Escherichia coli SMS-3-5 6143799 YP_001744859.1 CDS hypF NC_010498.1 2910351 2912639 R identified by similarity to SP:P30131; match to protein family HMM PF00708; match to protein family HMM PF01300; match to protein family HMM PF07503; match to protein family HMM TIGR00143; [NiFe] hydrogenase maturation protein HypF complement(2910351..2912639) Escherichia coli SMS-3-5 6145832 YP_001744860.1 CDS EcSMS35_2836 NC_010498.1 2912744 2913271 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(2912744..2913271) Escherichia coli SMS-3-5 6145126 YP_001744861.1 CDS EcSMS35_2837 NC_010498.1 2913249 2913416 R identified by Glimmer3; putative; hypothetical protein complement(2913249..2913416) Escherichia coli SMS-3-5 6147208 YP_001744862.1 CDS ascG NC_010498.1 2913420 2914472 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator AscG complement(2913420..2914472) Escherichia coli SMS-3-5 6146475 YP_001744863.1 CDS ascF NC_010498.1 2914690 2916147 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 2914690..2916147 Escherichia coli SMS-3-5 6147332 YP_001744864.1 CDS ascB NC_010498.1 2916156 2917580 D identified by match to protein family HMM PF00232; cryptic 6-phospho-beta-glucosidase 2916156..2917580 Escherichia coli SMS-3-5 6146316 YP_001744865.1 CDS EcSMS35_2841 NC_010498.1 2917667 2918422 R identified by similarity to GB:AAN81725.1; hypothetical protein complement(2917667..2918422) Escherichia coli SMS-3-5 6144591 YP_001744866.1 CDS hycI NC_010498.1 2918465 2918935 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(2918465..2918935) Escherichia coli SMS-3-5 6143941 YP_001744867.1 CDS EcSMS35_2843 NC_010498.1 2918928 2919338 R identified by match to protein family HMM PF07450; formate hydrogenlyase maturation protein complement(2918928..2919338) Escherichia coli SMS-3-5 6144146 YP_001744868.1 CDS hycG NC_010498.1 2919335 2920102 R identified by match to protein family HMM PF01058; formate hydrogenlyase, subunit G complement(2919335..2920102) Escherichia coli SMS-3-5 6143546 YP_001744869.1 CDS hycF NC_010498.1 2920102 2920644 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(2920102..2920644) Escherichia coli SMS-3-5 6142955 YP_001744870.1 CDS hycE NC_010498.1 2920654 2922384 R identified by match to protein family HMM PF00329; match to protein family HMM PF00346; formate hydrogenlyase, subunit E complement(2920654..2922384) Escherichia coli SMS-3-5 6146810 YP_001744871.1 CDS hycD NC_010498.1 2922381 2923304 R identified by match to protein family HMM PF00146; formate hydrogenlyase, subunit D complement(2922381..2923304) Escherichia coli SMS-3-5 6146153 YP_001744872.1 CDS hycC NC_010498.1 2923307 2925133 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(2923307..2925133) Escherichia coli SMS-3-5 6145730 YP_001744873.1 CDS hycB NC_010498.1 2925130 2925741 R identified by match to protein family HMM PF00037; formate hydrogenlyase, subunit B complement(2925130..2925741) Escherichia coli SMS-3-5 6143868 YP_001744874.1 CDS hycA NC_010498.1 2925866 2926327 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(2925866..2926327) Escherichia coli SMS-3-5 6143464 YP_001744875.1 CDS hypA NC_010498.1 2926527 2926889 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2926527..2926889 Escherichia coli SMS-3-5 6146662 YP_001744876.1 CDS hypB NC_010498.1 2926893 2927765 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2926893..2927765 Escherichia coli SMS-3-5 6147044 YP_001744877.1 CDS hypC2 NC_010498.1 2927756 2928028 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2927756..2928028 Escherichia coli SMS-3-5 6146486 YP_001744878.1 CDS hypD NC_010498.1 2928028 2929149 D identified by match to protein family HMM PF01924; match to protein family HMM TIGR00075; hydrogenase expression/formation protein HypD 2928028..2929149 Escherichia coli SMS-3-5 6147136 YP_001744879.1 CDS hypE NC_010498.1 2929146 2930156 D identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124; hydrogenase expression/formation protein HypE 2929146..2930156 Escherichia coli SMS-3-5 6145066 YP_001744880.1 CDS fhlA NC_010498.1 2930230 2932308 D identified by match to protein family HMM PF00158; match to protein family HMM PF01590; match to protein family HMM PF02954; match to protein family HMM PF07728; formate hydrogenlyase transcriptional activator 2930230..2932308 Escherichia coli SMS-3-5 6145750 YP_001744881.1 CDS EcSMS35_2857 NC_010498.1 2932314 2932781 D identified by match to protein family HMM PF03459; match to protein family HMM TIGR00638; molybdenum-pterin binding protein 2932314..2932781 Escherichia coli SMS-3-5 6143758 YP_001744882.1 CDS EcSMS35_2858 NC_010498.1 2932820 2933164 R ygbA; hypothetical protein complement(2932820..2933164) Escherichia coli SMS-3-5 6142911 YP_001744883.1 CDS EcSMS35_2859 NC_010498.1 2933241 2933375 R identified by Glimmer3; putative; hypothetical protein complement(2933241..2933375) Escherichia coli SMS-3-5 6143542 YP_001744884.1 CDS mutS NC_010498.1 2933451 2936012 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2933451..2936012 Escherichia coli SMS-3-5 6144403 YP_001744885.1 CDS pphB NC_010498.1 2936118 2936774 D identified by similarity to SP:P55799; match to protein family HMM PF00149; serine/threonine-specific protein phosphatase 2 2936118..2936774 Escherichia coli SMS-3-5 6144281 YP_001744886.1 CDS kpdD NC_010498.1 2936816 2937052 R 4-hydroxybenzoate decarboxylase, subunit D complement(2936816..2937052) Escherichia coli SMS-3-5 6144809 YP_001744887.1 CDS kpdC NC_010498.1 2937063 2938490 R identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; 4-hydroxybenzoate decarboxylase, subunit C complement(2937063..2938490) Escherichia coli SMS-3-5 6145321 YP_001744888.1 CDS kpdB NC_010498.1 2938490 2939083 R identified by match to protein family HMM PF02441; match to protein family HMM TIGR00421; 4-hydroxybenzoate decarboxylase, subunit B complement(2938490..2939083) Escherichia coli SMS-3-5 6145831 YP_001744889.1 CDS EcSMS35_2865 NC_010498.1 2939230 2939637 D identified by match to protein family HMM PF01047; MarR family transcriptional regulator 2939230..2939637 Escherichia coli SMS-3-5 6146993 YP_001744890.1 CDS rpoS NC_010498.1 2939757 2940749 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(2939757..2940749) Escherichia coli SMS-3-5 6147499 YP_001744891.1 CDS nlpD NC_010498.1 2940812 2941951 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(2940812..2941951) Escherichia coli SMS-3-5 6143460 YP_001744892.1 CDS pcm NC_010498.1 2942091 2942717 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(2942091..2942717) Escherichia coli SMS-3-5 6143829 YP_001744893.1 CDS surE NC_010498.1 2942711 2943478 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(2942711..2943478) Escherichia coli SMS-3-5 6146359 YP_001744894.1 CDS truD NC_010498.1 2943453 2944502 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(2943453..2944502) Escherichia coli SMS-3-5 6145553 YP_001744895.1 CDS ispF NC_010498.1 2944499 2944978 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(2944499..2944978) Escherichia coli SMS-3-5 6145232 YP_001744896.1 CDS ispD NC_010498.1 2944978 2945688 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(2944978..2945688) Escherichia coli SMS-3-5 6144541 YP_001744897.1 CDS ftsB NC_010498.1 2945707 2946018 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(2945707..2946018) Escherichia coli SMS-3-5 6145441 YP_001744898.1 CDS EcSMS35_2874 NC_010498.1 2946006 2946125 R identified by Glimmer3; putative; hypothetical protein complement(2946006..2946125) Escherichia coli SMS-3-5 6144765 YP_001744899.1 CDS EcSMS35_2875 NC_010498.1 2946212 2946535 R hypothetical protein complement(2946212..2946535) Escherichia coli SMS-3-5 6146369 YP_001744900.1 CDS cysC NC_010498.1 2946585 2947190 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(2946585..2947190) Escherichia coli SMS-3-5 6145640 YP_001744901.1 CDS cysN NC_010498.1 2947190 2948617 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(2947190..2948617) Escherichia coli SMS-3-5 6143154 YP_001744902.1 CDS cysD NC_010498.1 2948619 2949527 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(2948619..2949527) Escherichia coli SMS-3-5 6142609 YP_001744903.1 CDS iap NC_010498.1 2949779 2950816 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 2949779..2950816 Escherichia coli SMS-3-5 6144091 YP_001744905.1 CDS EcSMS35_2881 NC_010498.1 2951918 2952031 D identified by Glimmer3; putative; hypothetical protein 2951918..2952031 Escherichia coli SMS-3-5 6147493 YP_001744906.1 CDS cas2 NC_010498.1 2952306 2952593 R identified by match to protein family HMM TIGR01873; hypothetical protein complement(2952306..2952593) Escherichia coli SMS-3-5 6146254 YP_001744907.1 CDS cas1 NC_010498.1 2952596 2953519 R identified by match to protein family HMM TIGR00287; CRISPR-associated Cas1 family protein complement(2952596..2953519) Escherichia coli SMS-3-5 6143521 YP_001744908.1 CDS cse3 NC_010498.1 2953516 2954166 R identified by match to protein family HMM PF08798; match to protein family HMM TIGR01907; CRISPR-associated Cse3 family protein complement(2953516..2954166) Escherichia coli SMS-3-5 6146023 YP_001744909.1 CDS cas5e NC_010498.1 2954148 2954894 R identified by match to protein family HMM TIGR01868; match to protein family HMM TIGR02593; CRISPR-associated Cas5 family protein complement(2954148..2954894) Escherichia coli SMS-3-5 6145504 YP_001744910.1 CDS cse4 NC_010498.1 2954905 2955960 R identified by match to protein family HMM TIGR01869; CRISPR-associated Cse4 family protein complement(2954905..2955960) Escherichia coli SMS-3-5 6144643 YP_001744911.1 CDS cse2 NC_010498.1 2955975 2956511 R identified by match to protein family HMM TIGR02548; CRISPR-associated Cse2 family protein complement(2955975..2956511) Escherichia coli SMS-3-5 6144133 YP_001744912.1 CDS cse1 NC_010498.1 2956508 2958070 R identified by match to protein family HMM TIGR02547; CRISPR-associated Cse1 family protein complement(2956508..2958070) Escherichia coli SMS-3-5 6144590 YP_001744913.1 CDS cas3 NC_010498.1 2958168 2960867 R identified by match to protein family HMM TIGR01587; CRISPR-associated helicase Cas3 complement(2958168..2960867) Escherichia coli SMS-3-5 6147428 YP_001744914.1 CDS cysH NC_010498.1 2961479 2962213 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(2961479..2962213) Escherichia coli SMS-3-5 6144779 YP_001744915.1 CDS cysI NC_010498.1 2962287 2963999 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(2962287..2963999) Escherichia coli SMS-3-5 6144259 YP_001744916.1 CDS cysJ NC_010498.1 2963999 2965798 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(2963999..2965798) Escherichia coli SMS-3-5 6145502 YP_001744917.1 CDS EcSMS35_2893 NC_010498.1 2966011 2966124 R identified by Glimmer3; putative; hypothetical protein complement(2966011..2966124) Escherichia coli SMS-3-5 6144718 YP_001744918.1 CDS queD NC_010498.1 2966117 2966479 D identified by match to protein family HMM PF01242; match to protein family HMM TIGR00039; match to protein family HMM TIGR03367; queuosine biosynthesis protein QueD 2966117..2966479 Escherichia coli SMS-3-5 6146953 YP_001744919.1 CDS EcSMS35_2895 NC_010498.1 2966557 2967828 D identified by match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM PF03486; match to protein family HMM PF07992; pyridine nucleotide-disulphide oxidoreductase family protein 2966557..2967828 Escherichia coli SMS-3-5 6146384 YP_001744920.1 CDS EcSMS35_2896 NC_010498.1 2967819 2968079 D identified by match to protein family HMM PF00037; putative ferredoxin 2967819..2968079 Escherichia coli SMS-3-5 6142646 YP_001744921.1 CDS EcSMS35_2897 NC_010498.1 2968096 2968671 D identified by match to protein family HMM PF04309; glycerol-3-phosphate responsive antiterminator 2968096..2968671 Escherichia coli SMS-3-5 6146772 YP_001744922.1 CDS EcSMS35_2898 NC_010498.1 2968818 2969678 R identified by match to protein family HMM PF00766; electron transfer flavoprotein complement(2968818..2969678) Escherichia coli SMS-3-5 6143845 YP_001744923.1 CDS EcSMS35_2899 NC_010498.1 2969675 2970454 R identified by match to protein family HMM PF01012; electron transfer flavoprotein complement(2969675..2970454) Escherichia coli SMS-3-5 6147089 YP_001744924.1 CDS EcSMS35_2900 NC_010498.1 2970432 2971769 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter complement(2970432..2971769) Escherichia coli SMS-3-5 6145029 YP_001744925.1 CDS EcSMS35_2901 NC_010498.1 2971863 2973317 R identified by match to protein family HMM PF01565; match to protein family HMM PF02913; FAD binding domain-containing protein complement(2971863..2973317) Escherichia coli SMS-3-5 6146009 YP_001744926.1 CDS EcSMS35_2902 NC_010498.1 2973387 2974172 R identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase complement(2973387..2974172) Escherichia coli SMS-3-5 6143955 YP_001744927.1 CDS EcSMS35_2903 NC_010498.1 2974490 2975767 D identified by match to protein family HMM PF07690; major facilitator family transporter 2974490..2975767 Escherichia coli SMS-3-5 6144589 YP_001744928.1 CDS EcSMS35_2904 NC_010498.1 2975794 2977272 D identified by match to protein family HMM PF00370; match to protein family HMM PF02782; carbohydrate kinase, FGGY family protein 2975794..2977272 Escherichia coli SMS-3-5 6142718 YP_001744929.1 CDS scrK NC_010498.1 2977437 2978357 D phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 2977437..2978357 Escherichia coli SMS-3-5 6143957 YP_001744930.1 CDS scrY NC_010498.1 2978525 2980042 D identified by similarity to SP:P22340; match to protein family HMM PF02264; sucrose porin ScrY 2978525..2980042 Escherichia coli SMS-3-5 6146601 YP_001744931.1 CDS scrA NC_010498.1 2980103 2981473 D identified by similarity to SP:P08470; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00852; match to protein family HMM TIGR01996; PTS system sucrose-specific EIIBC component ScrA 2980103..2981473 Escherichia coli SMS-3-5 6147105 YP_001744932.1 CDS scrB NC_010498.1 2981479 2982882 D identified by similarity to SP:P37075; match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; beta-fructofuranosidase 2981479..2982882 Escherichia coli SMS-3-5 6145589 YP_001744933.1 CDS scrR NC_010498.1 2982908 2983915 D identified by similarity to SP:P37076; match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR02417; sucrose operon repressor 2982908..2983915 Escherichia coli SMS-3-5 6144872 YP_001744934.1 CDS EcSMS35_2910 NC_010498.1 2984001 2984672 R hypothetical protein complement(2984001..2984672) Escherichia coli SMS-3-5 6147014 YP_001744935.1 CDS EcSMS35_2911 NC_010498.1 2984706 2984819 D identified by Glimmer3; putative; hypothetical protein 2984706..2984819 Escherichia coli SMS-3-5 6146299 YP_001744936.1 CDS EcSMS35_2912 NC_010498.1 2984845 2985447 D identified by match to protein family HMM PF04011; LemA family protein 2984845..2985447 Escherichia coli SMS-3-5 6145282 YP_001744937.1 CDS EcSMS35_2913 NC_010498.1 2985461 2986354 D identified by similarity to GB:ABF04769.1; match to protein family HMM PF04536; hypothetical protein 2985461..2986354 Escherichia coli SMS-3-5 6147008 YP_001744938.1 CDS EcSMS35_2914 NC_010498.1 2986369 2987517 D identified by match to protein family HMM PF04536; hypothetical protein 2986369..2987517 Escherichia coli SMS-3-5 6144218 YP_001744939.1 CDS EcSMS35_2915 NC_010498.1 2987511 2988395 D identified by match to protein family HMM PF04536; hypothetical protein 2987511..2988395 Escherichia coli SMS-3-5 6145869 YP_001744940.1 CDS EcSMS35_2916 NC_010498.1 2988512 2989840 D identified by match to protein family HMM PF01609; IS4 transposase 2988512..2989840 Escherichia coli SMS-3-5 6147366 YP_001744941.1 CDS eno NC_010498.1 2989895 2991193 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(2989895..2991193) Escherichia coli SMS-3-5 6144426 YP_001744942.1 CDS pyrG NC_010498.1 2991280 2992917 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(2991280..2992917) Escherichia coli SMS-3-5 6143508 YP_001744943.1 CDS mazG NC_010498.1 2993145 2993936 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(2993145..2993936) Escherichia coli SMS-3-5 6144592 YP_001744944.1 CDS chpA NC_010498.1 2994008 2994343 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(2994008..2994343) Escherichia coli SMS-3-5 6146305 YP_001744945.1 CDS chpR NC_010498.1 2994343 2994591 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(2994343..2994591) Escherichia coli SMS-3-5 6142821 YP_001744946.1 CDS relA NC_010498.1 2994669 2996903 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(2994669..2996903) Escherichia coli SMS-3-5 6147090 YP_001744947.1 CDS rumA NC_010498.1 2996951 2998252 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(2996951..2998252) Escherichia coli SMS-3-5 6146651 YP_001744948.1 CDS barA NC_010498.1 2998309 3001065 D part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2998309..3001065 Escherichia coli SMS-3-5 6145736 YP_001744949.1 CDS EcSMS35_2925 NC_010498.1 3001296 3002636 R identified by match to protein family HMM PF01188; match to protein family HMM TIGR03247; glucarate dehydratase complement(3001296..3002636) Escherichia coli SMS-3-5 6145081 YP_001744950.1 CDS EcSMS35_2926 NC_010498.1 3002657 3003997 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; glucarate dehydratase complement(3002657..3003997) Escherichia coli SMS-3-5 6144502 YP_001744951.1 CDS gudP NC_010498.1 3003999 3005351 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00893; glucarate permease complement(3003999..3005351) Escherichia coli SMS-3-5 6143995 YP_001744952.1 CDS EcSMS35_2928 NC_010498.1 3005446 3005571 R identified by Glimmer3; putative; hypothetical protein complement(3005446..3005571) Escherichia coli SMS-3-5 6143514 YP_001744953.1 CDS EcSMS35_2929 NC_010498.1 3005565 3005693 D identified by Glimmer3; putative; hypothetical protein 3005565..3005693 Escherichia coli SMS-3-5 6143073 YP_001744954.1 CDS EcSMS35_2930 NC_010498.1 3005786 3006235 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(3005786..3006235) Escherichia coli SMS-3-5 6146015 YP_001744955.1 CDS truC NC_010498.1 3006253 3007035 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(3006253..3007035) Escherichia coli SMS-3-5 6143855 YP_001744956.1 CDS EcSMS35_2932 NC_010498.1 3007035 3007364 R identified by match to protein family HMM PF04287; hypothetical protein complement(3007035..3007364) Escherichia coli SMS-3-5 6147055 YP_001744957.1 CDS EcSMS35_2933 NC_010498.1 3007986 3008531 R putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(3007986..3008531) Escherichia coli SMS-3-5 6145492 YP_001744958.1 CDS queF NC_010498.1 3008599 3009447 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3008599..3009447 Escherichia coli SMS-3-5 6142799 YP_001744959.1 CDS EcSMS35_2935 NC_010498.1 3009559 3010923 D identified by match to protein family HMM PF03641; hypothetical protein 3009559..3010923 Escherichia coli SMS-3-5 6143346 YP_001744960.1 CDS EcSMS35_2936 NC_010498.1 3011479 3012768 D identified by match to protein family HMM TIGR00814; serine transporter family protein 3011479..3012768 Escherichia coli SMS-3-5 6144549 YP_001744961.1 CDS sdaB NC_010498.1 3012826 3014193 D identified by similarity to SP:P30744; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase 2 3012826..3014193 Escherichia coli SMS-3-5 6147516 YP_001744962.1 CDS xni NC_010498.1 3014304 3015059 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3014304..3015059 Escherichia coli SMS-3-5 6144953 YP_001744963.1 CDS fucO NC_010498.1 3015164 3016315 R identified by match to protein family HMM PF00465; match to protein family HMM TIGR02638; L-1,2-propanediol oxidoreductase complement(3015164..3016315) Escherichia coli SMS-3-5 6145785 YP_001744964.1 CDS fucA NC_010498.1 3016340 3016987 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(3016340..3016987) Escherichia coli SMS-3-5 6147040 YP_001744965.1 CDS EcSMS35_2941 NC_010498.1 3017177 3017314 D identified by Glimmer3; putative; hypothetical protein 3017177..3017314 Escherichia coli SMS-3-5 6146329 YP_001744966.1 CDS fucP NC_010498.1 3017534 3018850 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00885; L-fucose transporter 3017534..3018850 Escherichia coli SMS-3-5 6143128 YP_001744967.1 CDS fucI NC_010498.1 3018883 3020658 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3018883..3020658 Escherichia coli SMS-3-5 6147383 YP_001744968.1 CDS fucK NC_010498.1 3020767 3022185 D identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR02628; L-fuculokinase 3020767..3022185 Escherichia coli SMS-3-5 6147088 YP_001744969.1 CDS fucU NC_010498.1 3022187 3022609 D identified by match to protein family HMM PF05025; fucose operon protein FucU 3022187..3022609 Escherichia coli SMS-3-5 6146362 YP_001744970.1 CDS fucR NC_010498.1 3022667 3023398 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3022667..3023398 Escherichia coli SMS-3-5 6143179 YP_001744971.1 CDS EcSMS35_2947 NC_010498.1 3023442 3024542 R putative RNA 2'-O-ribose methyltransferase complement(3023442..3024542) Escherichia coli SMS-3-5 6147378 YP_001744972.1 CDS EcSMS35_2948 NC_010498.1 3024535 3024930 R identified by match to protein family HMM PF04241; hypothetical protein complement(3024535..3024930) Escherichia coli SMS-3-5 6144984 YP_001744973.1 CDS gcvA NC_010498.1 3024949 3025866 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(3024949..3025866) Escherichia coli SMS-3-5 6143453 YP_001744974.1 CDS EcSMS35_2950 NC_010498.1 3026218 3026445 R identified by match to protein family HMM PF06004; putative lipoprotein complement(3026218..3026445) Escherichia coli SMS-3-5 6145947 YP_001744975.1 CDS csdA NC_010498.1 3026637 3027842 D identified by match to protein family HMM PF00266; match to protein family HMM TIGR03392; cysteine sulfinate desulfinase 3026637..3027842 Escherichia coli SMS-3-5 6146569 YP_001744976.1 CDS csdE NC_010498.1 3027842 3028285 D identified by match to protein family HMM PF02657; match to protein family HMM TIGR03391; cysteine desulfurase, sulfur acceptor subunit CsdE 3027842..3028285 Escherichia coli SMS-3-5 6144847 YP_001744977.1 CDS EcSMS35_2953 NC_010498.1 3028336 3029136 R identified by match to protein family HMM PF00899; ThiF family protein complement(3028336..3029136) Escherichia coli SMS-3-5 6145614 YP_001744978.1 CDS mltA NC_010498.1 3029219 3030286 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(3029219..3030286) Escherichia coli SMS-3-5 6144483 YP_001744979.1 CDS EcSMS35_2958 NC_010498.1 3030901 3031848 R identified by match to protein family HMM PF00389; match to protein family HMM PF02826; D-isomer specific 2-hydroxyacid dehydrogenase family protein complement(3030901..3031848) Escherichia coli SMS-3-5 6143708 YP_001744980.1 CDS EcSMS35_2959 NC_010498.1 3031920 3032516 R identified by match to protein family HMM PF01380; KpsF/GutQ family sugar isomerase complement(3031920..3032516) Escherichia coli SMS-3-5 6143418 YP_001744981.1 CDS EcSMS35_2960 NC_010498.1 3032519 3033694 R identified by match to protein family HMM PF00155; aminotransferase, classes I and II complement(3032519..3033694) Escherichia coli SMS-3-5 6144307 YP_001744982.1 CDS EcSMS35_2961 NC_010498.1 3033694 3035274 R identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; PTS system, maltose and glucose-specific IIBC component family protein complement(3033694..3035274) Escherichia coli SMS-3-5 6146566 YP_001744983.1 CDS EcSMS35_2962 NC_010498.1 3035306 3036130 R identified by match to protein family HMM PF00874; match to protein family HMM PF03123; putative transcriptional antiterminator complement(3035306..3036130) Escherichia coli SMS-3-5 6147508 YP_001744984.1 CDS EcSMS35_2963 NC_010498.1 3036226 3036378 D identified by Glimmer3; putative; hypothetical protein 3036226..3036378 Escherichia coli SMS-3-5 6145121 YP_001744985.1 CDS amiC1 NC_010498.1 3036388 3037641 R identified by similarity to SP:P63883; match to protein family HMM PF01520; match to protein family HMM TIGR01409; N-acetylmuramoyl-L-alanine amidase AmiC complement(3036388..3037641) Escherichia coli SMS-3-5 6145539 YP_001744986.1 CDS argA NC_010498.1 3037873 3039204 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3037873..3039204 Escherichia coli SMS-3-5 6145876 YP_001744987.1 CDS recD NC_010498.1 3039266 3041092 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(3039266..3041092) Escherichia coli SMS-3-5 6144600 YP_001744988.1 CDS recB NC_010498.1 3041092 3044604 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(3041092..3044604) Escherichia coli SMS-3-5 6142819 YP_001744989.1 CDS ptrA NC_010498.1 3044627 3047515 R identified by match to protein family HMM PF00675; match to protein family HMM PF05193; protease III complement(3044627..3047515) Escherichia coli SMS-3-5 6143373 YP_001744990.1 CDS recC NC_010498.1 3047691 3051059 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(3047691..3051059) Escherichia coli SMS-3-5 6146657 YP_001744991.1 CDS ppdC NC_010498.1 3051072 3051419 R identified by match to protein family HMM TIGR02532; hypothetical protein complement(3051072..3051419) Escherichia coli SMS-3-5 6147250 YP_001744992.1 CDS EcSMS35_2971 NC_010498.1 3051380 3051787 R hypothetical protein complement(3051380..3051787) Escherichia coli SMS-3-5 6146913 YP_001744993.1 CDS ppdB NC_010498.1 3051784 3052347 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; hypothetical protein complement(3051784..3052347) Escherichia coli SMS-3-5 6147236 YP_001744994.1 CDS ppdA NC_010498.1 3052338 3052808 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; hypothetical protein complement(3052338..3052808) Escherichia coli SMS-3-5 6144943 YP_001744995.1 CDS thyA NC_010498.1 3052993 3053787 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3052993..3053787) Escherichia coli SMS-3-5 6144583 YP_001744996.1 CDS lgt NC_010498.1 3053794 3054669 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(3053794..3054669) Escherichia coli SMS-3-5 6143564 YP_001744997.1 CDS ptsP NC_010498.1 3054820 3057066 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(3054820..3057066) Escherichia coli SMS-3-5 6143111 YP_001744998.1 CDS nudH NC_010498.1 3057079 3057609 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(3057079..3057609) Escherichia coli SMS-3-5 6147150 YP_001744999.1 CDS EcSMS35_2978 NC_010498.1 3058054 3058215 D identified by Glimmer3; putative; hypothetical protein 3058054..3058215 Escherichia coli SMS-3-5 6146462 YP_001745000.1 CDS mutH NC_010498.1 3058294 3058983 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3058294..3058983 Escherichia coli SMS-3-5 6145783 YP_001745001.1 CDS EcSMS35_2980 NC_010498.1 3059052 3059765 D identified by match to protein family HMM PF03741; TerC family integral membrane protein 3059052..3059765 Escherichia coli SMS-3-5 6145122 YP_001745002.1 CDS EcSMS35_2981 NC_010498.1 3059903 3060121 D identified by match to protein family HMM PF06004; putative lipoprotein 3059903..3060121 Escherichia coli SMS-3-5 6145788 YP_001745003.1 CDS tas NC_010498.1 3060229 3061269 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3060229..3061269 Escherichia coli SMS-3-5 6144810 YP_001745004.1 CDS lplT NC_010498.1 3061301 3062494 R identified by match to protein family HMM PF07690; lysophospholipid transporter LplT complement(3061301..3062494) Escherichia coli SMS-3-5 6145358 YP_001745005.1 CDS aas NC_010498.1 3062487 3064646 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(3062487..3064646) Escherichia coli SMS-3-5 6147416 YP_001745006.1 CDS galR NC_010498.1 3065232 3066263 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3065232..3066263 Escherichia coli SMS-3-5 6143007 YP_001745007.1 CDS lysA NC_010498.1 3066270 3067532 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(3066270..3067532) Escherichia coli SMS-3-5 6146940 YP_001745008.1 CDS lysR NC_010498.1 3067654 3068589 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3067654..3068589 Escherichia coli SMS-3-5 6147432 YP_001745009.1 CDS EcSMS35_2987 NC_010498.1 3068576 3069268 R identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035; putative racemase complement(3068576..3069268) Escherichia coli SMS-3-5 6146229 YP_001745010.1 CDS araE NC_010498.1 3069397 3070815 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879; arabinose-proton symporter complement(3069397..3070815) Escherichia coli SMS-3-5 6145568 YP_001745011.1 CDS kduD NC_010498.1 3071130 3071891 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3071130..3071891) Escherichia coli SMS-3-5 6145401 YP_001745012.1 CDS kduI NC_010498.1 3071921 3072757 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3071921..3072757) Escherichia coli SMS-3-5 6146072 YP_001745013.1 CDS EcSMS35_2992 NC_010498.1 3073044 3074225 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3073044..3074225) Escherichia coli SMS-3-5 6144728 YP_001745014.1 CDS EcSMS35_2993 NC_010498.1 3074481 3075710 D identified by match to protein family HMM PF01490; match to protein family HMM TIGR00814; serine transporter family protein 3074481..3075710 Escherichia coli SMS-3-5 6144579 YP_001745015.1 CDS EcSMS35_2994 NC_010498.1 3076284 3076802 D hypothetical protein 3076284..3076802 Escherichia coli SMS-3-5 6143583 YP_001745016.1 CDS EcSMS35_2995 NC_010498.1 3076987 3077199 D IS1 transposase orfA 3076987..3077199 Escherichia coli SMS-3-5 6144096 YP_001745017.1 CDS EcSMS35_2996 NC_010498.1 3077210 3077713 D identified by match to protein family HMM PF03400; IS1 transposase orfB 3077210..3077713 Escherichia coli SMS-3-5 6146926 YP_001745018.1 CDS EcSMS35_2998 NC_010498.1 3078118 3078870 R identified by match to protein family HMM PF01476; match to protein family HMM PF01551; M23B family peptidase complement(3078118..3078870) Escherichia coli SMS-3-5 6143690 YP_001745019.1 CDS xdhA NC_010498.1 3079286 3081583 D putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3079286..3081583 Escherichia coli SMS-3-5 6147376 YP_001745020.1 CDS xdhB NC_010498.1 3081594 3082472 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3081594..3082472 Escherichia coli SMS-3-5 6145759 YP_001745021.1 CDS xdhC NC_010498.1 3082469 3082948 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3082469..3082948 Escherichia coli SMS-3-5 6146237 YP_001745022.1 CDS EcSMS35_3002 NC_010498.1 3082988 3084766 R identified by match to protein family HMM PF00158; match to protein family HMM PF02954; sigma-54 dependent trancsriptional regulator complement(3082988..3084766) Escherichia coli SMS-3-5 6145301 YP_001745023.1 CDS EcSMS35_3003 NC_010498.1 3085243 3086433 D identified by match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR03316; aspartate/ornithine carbamoyltransferase family protein 3085243..3086433 Escherichia coli SMS-3-5 6145828 YP_001745024.1 CDS EcSMS35_3004 NC_010498.1 3086491 3087687 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3086491..3087687 Escherichia coli SMS-3-5 6146893 YP_001745025.1 CDS EcSMS35_3005 NC_010498.1 3087745 3088956 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3087745..3088956 Escherichia coli SMS-3-5 6145245 YP_001745026.1 CDS hyuA NC_010498.1 3088997 3090394 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3088997..3090394 Escherichia coli SMS-3-5 6143431 YP_001745027.1 CDS EcSMS35_3007 NC_010498.1 3090442 3091374 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3090442..3091374 Escherichia coli SMS-3-5 6146642 YP_001745028.1 CDS EcSMS35_3008 NC_010498.1 3091415 3093040 R identified by match to protein family HMM PF00364; match to protein family HMM PF02625; match to protein family HMM TIGR03309; putative xanthine dehydrogenase accessory factor complement(3091415..3093040) Escherichia coli SMS-3-5 6144895 YP_001745029.1 CDS EcSMS35_3009 NC_010498.1 3093088 3093858 R identified by match to protein family HMM TIGR03172; hypothetical protein complement(3093088..3093858) Escherichia coli SMS-3-5 6144388 YP_001745030.1 CDS EcSMS35_3010 NC_010498.1 3093961 3094539 D identified by match to protein family HMM TIGR03310; hypothetical protein 3093961..3094539 Escherichia coli SMS-3-5 6145046 YP_001745031.1 CDS EcSMS35_3011 NC_010498.1 3094861 3097959 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3094861..3097959 Escherichia coli SMS-3-5 6145666 YP_001745032.1 CDS ssnA NC_010498.1 3097962 3099290 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3097962..3099290 Escherichia coli SMS-3-5 6145572 YP_001745033.1 CDS EcSMS35_3013 NC_010498.1 3099341 3100120 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3099341..3100120 Escherichia coli SMS-3-5 6144904 YP_001745034.1 CDS EcSMS35_3014 NC_010498.1 3100117 3102987 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3100117..3102987 Escherichia coli SMS-3-5 6146409 YP_001745035.1 CDS EcSMS35_3015 NC_010498.1 3103152 3104552 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine/uracil permease family protein 3103152..3104552 Escherichia coli SMS-3-5 6142729 YP_001745036.1 CDS guaD NC_010498.1 3104570 3105886 D Catalyzes the deamination of guanine; guanine deaminase 3104570..3105886 Escherichia coli SMS-3-5 6145996 YP_001745037.1 CDS EcSMS35_3017 NC_010498.1 3105922 3107289 D identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease family inorganic anion transporter 3105922..3107289 Escherichia coli SMS-3-5 6146626 YP_001745038.1 CDS EcSMS35_3018 NC_010498.1 3107325 3107813 R identified by match to protein family HMM PF00037; 4Fe-4S binding protein complement(3107325..3107813) Escherichia coli SMS-3-5 6144898 YP_001745039.1 CDS aegA2 NC_010498.1 3107813 3109747 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit complement(3107813..3109747) Escherichia coli SMS-3-5 6145012 YP_001745040.1 CDS EcSMS35_3020 NC_010498.1 3110039 3111616 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; putative xanthine permease 3110039..3111616 Escherichia coli SMS-3-5 6143151 YP_001745041.1 CDS EcSMS35_3021 NC_010498.1 3111618 3111743 D identified by Glimmer3; putative; hypothetical protein 3111618..3111743 Escherichia coli SMS-3-5 6143846 YP_001745042.1 CDS idi NC_010498.1 3111866 3112414 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3111866..3112414 Escherichia coli SMS-3-5 6142778 YP_001745043.1 CDS lysS NC_010498.1 3112457 3113974 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3112457..3113974) Escherichia coli SMS-3-5 6143305 YP_001745044.1 CDS prfB NC_010498.1 3113984 3115082 R programmed frameshift; recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3113984..3115006,3115008..3115082)) Escherichia coli SMS-3-5 6146906 YP_001745045.1 CDS recJ NC_010498.1 3115173 3116906 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3115173..3116906) Escherichia coli SMS-3-5 6146377 YP_001745046.1 CDS dsbC NC_010498.1 3116912 3117622 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3116912..3117622) Escherichia coli SMS-3-5 6142675 YP_001745047.1 CDS xerD NC_010498.1 3117647 3118543 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3117647..3118543) Escherichia coli SMS-3-5 6146839 YP_001745048.1 CDS fldB NC_010498.1 3118655 3119176 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3118655..3119176 Escherichia coli SMS-3-5 6146187 YP_001745049.1 CDS EcSMS35_3029 NC_010498.1 3119216 3119623 R identified by match to protein family HMM PF07254; hypothetical protein complement(3119216..3119623) Escherichia coli SMS-3-5 6143221 YP_001745050.1 CDS EcSMS35_3030 NC_010498.1 3119604 3119870 R identified by match to protein family HMM PF03937; hypothetical protein complement(3119604..3119870) Escherichia coli SMS-3-5 6142668 YP_001745051.1 CDS ygfZ NC_010498.1 3120113 3121093 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3120113..3121093 Escherichia coli SMS-3-5 6144047 YP_001745052.1 CDS EcSMS35_3032 NC_010498.1 3121170 3121829 R identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin III family channel protein complement(3121170..3121829) Escherichia coli SMS-3-5 6143226 YP_001745053.1 CDS EcSMS35_3033 NC_010498.1 3121993 3122304 R identified by match to protein family HMM PF06164; hypothetical protein complement(3121993..3122304) Escherichia coli SMS-3-5 6146702 YP_001745054.1 CDS bglA NC_010498.1 3122343 3123782 D identified by match to protein family HMM PF00232; 6-phospho-beta-glucosidase BglA 3122343..3123782 Escherichia coli SMS-3-5 6147280 YP_001745055.1 CDS gcvP NC_010498.1 3123946 3126819 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3123946..3126819) Escherichia coli SMS-3-5 6145622 YP_001745056.1 CDS gcvH NC_010498.1 3126938 3127327 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3126938..3127327) Escherichia coli SMS-3-5 6143938 YP_001745057.1 CDS gcvT NC_010498.1 3127351 3128445 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3127351..3128445) Escherichia coli SMS-3-5 6144606 YP_001745058.1 CDS EcSMS35_3038 NC_010498.1 3128621 3128749 R hypothetical protein complement(3128621..3128749) Escherichia coli SMS-3-5 6142710 YP_001745059.1 CDS EcSMS35_3039 NC_010498.1 3128706 3128819 D identified by Glimmer3; putative; hypothetical protein 3128706..3128819 Escherichia coli SMS-3-5 6143298 YP_001745060.1 CDS EcSMS35_3040 NC_010498.1 3128893 3130095 R identified by match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM TIGR01988; hypothetical protein complement(3128893..3130095) Escherichia coli SMS-3-5 6146532 YP_001745061.1 CDS ubiH NC_010498.1 3130118 3131296 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3130118..3131296) Escherichia coli SMS-3-5 6147315 YP_001745062.1 CDS pepP NC_010498.1 3131293 3132618 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3131293..3132618) Escherichia coli SMS-3-5 6145089 YP_001745063.1 CDS EcSMS35_3043 NC_010498.1 3132644 3133228 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3132644..3133228) Escherichia coli SMS-3-5 6145097 YP_001745064.1 CDS EcSMS35_3044 NC_010498.1 3133390 3133719 D identified by match to protein family HMM PF05164; Z-ring-associated protein 3133390..3133719 Escherichia coli SMS-3-5 6145682 YP_001745065.1 CDS EcSMS35_3045 NC_010498.1 3133965 3134567 D ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; putative ligase 3133965..3134567 Escherichia coli SMS-3-5 6146147 YP_001745066.1 CDS serA NC_010498.1 3134956 3136188 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3134956..3136188) Escherichia coli SMS-3-5 6147285 YP_001745067.1 CDS rpiA NC_010498.1 3136444 3137103 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3136444..3137103) Escherichia coli SMS-3-5 6142864 YP_001745068.1 CDS EcSMS35_3048 NC_010498.1 3137159 3138055 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(3137159..3138055) Escherichia coli SMS-3-5 6143523 YP_001745069.1 CDS EcSMS35_3049 NC_010498.1 3138156 3138785 D identified by similarity to SP:Q9L867; match to protein family HMM PF02525; azoreductase type 1 family protein 3138156..3138785 Escherichia coli SMS-3-5 6144166 YP_001745070.1 CDS EcSMS35_3050 NC_010498.1 3138802 3139062 D identified by match to protein family HMM PF07338; hypothetical protein 3138802..3139062 Escherichia coli SMS-3-5 6144666 YP_001745071.1 CDS EcSMS35_3051 NC_010498.1 3139124 3140449 D identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; match to protein family HMM PF08022; ferric reductase/oxidoreductase, FAD/NAD binding 3139124..3140449 Escherichia coli SMS-3-5 6144482 YP_001745072.1 CDS iciA NC_010498.1 3140520 3141413 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3140520..3141413 Escherichia coli SMS-3-5 6144990 YP_001745073.1 CDS msm NC_010498.1 3141616 3143760 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3141616..3143760 Escherichia coli SMS-3-5 6143445 YP_001745074.1 CDS EcSMS35_3054 NC_010498.1 3143753 3144748 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3143753..3144748 Escherichia coli SMS-3-5 6147474 YP_001745075.1 CDS EcSMS35_3055 NC_010498.1 3144759 3145544 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3144759..3145544 Escherichia coli SMS-3-5 6147235 YP_001745076.1 CDS EcSMS35_3057 NC_010498.1 3145568 3147046 D identified by match to protein family HMM PF02550; match to protein family HMM TIGR03458; acetyl-CoA hydrolase/transferase 3145568..3147046 Escherichia coli SMS-3-5 6146268 YP_001745077.1 CDS EcSMS35_3056 NC_010498.1 3147043 3147939 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(3147043..3147939) Escherichia coli SMS-3-5 6145841 YP_001745078.1 CDS EcSMS35_3058 NC_010498.1 3148107 3148847 R identified by match to protein family HMM PF04402; hypothetical protein complement(3148107..3148847) Escherichia coli SMS-3-5 6145721 YP_001745079.1 CDS argO NC_010498.1 3148940 3149575 R Involved in the export of arginine; arginine exporter protein complement(3148940..3149575) Escherichia coli SMS-3-5 6145318 YP_001745080.1 CDS EcSMS35_3060 NC_010498.1 3149691 3150734 D identified by match to protein family HMM PF03480; solute-binding family 7 protein 3149691..3150734 Escherichia coli SMS-3-5 6144830 YP_001745081.1 CDS mscS NC_010498.1 3150776 3151651 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(3150776..3151651) Escherichia coli SMS-3-5 6144121 YP_001745082.1 CDS fbaA NC_010498.1 3152009 3153088 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3152009..3153088) Escherichia coli SMS-3-5 6146888 YP_001745083.1 CDS pgk NC_010498.1 3153302 3154465 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3153302..3154465) Escherichia coli SMS-3-5 6145576 YP_001745084.1 CDS epd NC_010498.1 3154515 3155534 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3154515..3155534) Escherichia coli SMS-3-5 6145352 YP_001745085.1 CDS EcSMS35_3065 NC_010498.1 3155906 3156337 D identified by match to protein family HMM PF03479; hypothetical protein 3155906..3156337 Escherichia coli SMS-3-5 6143969 YP_001745086.1 CDS EcSMS35_3066 NC_010498.1 3156360 3156938 D hypothetical protein 3156360..3156938 Escherichia coli SMS-3-5 6144284 YP_001745087.1 CDS EcSMS35_3067 NC_010498.1 3156939 3157646 D hypothetical protein 3156939..3157646 Escherichia coli SMS-3-5 6143410 YP_001745088.1 CDS EcSMS35_3068 NC_010498.1 3157628 3158311 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 3157628..3158311 Escherichia coli SMS-3-5 6147254 YP_001745089.1 CDS EcSMS35_3070 NC_010498.1 3158305 3158982 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 3158305..3158982 Escherichia coli SMS-3-5 6146692 YP_001745090.1 CDS frcK NC_010498.1 3158954 3159667 R putative fructose transport system kinase complement(3158954..3159667) Escherichia coli SMS-3-5 6144981 YP_001745091.1 CDS EcSMS35_3071 NC_010498.1 3159664 3160173 R identified by match to protein family HMM PF05068; putative DNA-binding transcriptional regulator complement(3159664..3160173) Escherichia coli SMS-3-5 6145791 YP_001745092.1 CDS glpX2 NC_010498.1 3160195 3161160 R identified by match to protein family HMM PF03320; match to protein family HMM TIGR00330; fructose-1,6-bisphosphatase II-like protein complement(3160195..3161160) Escherichia coli SMS-3-5 6143848 YP_001745093.1 CDS sorE NC_010498.1 3161157 3162434 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; L-sorbose 1-phosphate reductase complement(3161157..3162434) Escherichia coli SMS-3-5 6144197 YP_001745094.1 CDS cmtB NC_010498.1 3163865 3164308 R TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA complement(3163865..3164308) Escherichia coli SMS-3-5 6143813 YP_001745095.1 CDS EcSMS35_3076 NC_010498.1 3164685 3165593 D identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein 3164685..3165593 Escherichia coli SMS-3-5 6144470 YP_001745096.1 CDS tktA NC_010498.1 3165813 3167804 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3165813..3167804) Escherichia coli SMS-3-5 6144686 YP_001745097.1 CDS EcSMS35_3078 NC_010498.1 3168082 3168840 D identified by match to protein family HMM PF01435; M48B family peptidase 3168082..3168840 Escherichia coli SMS-3-5 6146047 YP_001745098.1 CDS speB NC_010498.1 3168888 3169808 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3168888..3169808) Escherichia coli SMS-3-5 6146468 YP_001745099.1 CDS EcSMS35_3080 NC_010498.1 3169944 3170675 R putative lipoprotein complement(3169944..3170675) Escherichia coli SMS-3-5 6147174 YP_001745100.1 CDS speA NC_010498.1 3170821 3172719 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3170821..3172719) Escherichia coli SMS-3-5 6142594 YP_001745101.1 CDS EcSMS35_3082 NC_010498.1 3172806 3172937 R hypothetical protein complement(3172806..3172937) Escherichia coli SMS-3-5 6143824 YP_001745102.1 CDS EcSMS35_3083 NC_010498.1 3173285 3173536 R identified by similarity to RF:NP_838428.1; hypothetical protein complement(3173285..3173536) Escherichia coli SMS-3-5 6145310 YP_001745103.1 CDS metK NC_010498.1 3173592 3174746 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3173592..3174746 Escherichia coli SMS-3-5 6144193 YP_001745104.1 CDS galP NC_010498.1 3175182 3176576 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879; galactose-proton symporter 3175182..3176576 Escherichia coli SMS-3-5 6145909 YP_001745105.1 CDS sprT NC_010498.1 3176653 3177150 D identified by match to protein family HMM PF03926; hypothetical protein 3176653..3177150 Escherichia coli SMS-3-5 6145273 YP_001745106.1 CDS endA NC_010498.1 3177245 3177952 D identified by match to protein family HMM PF04231; endonuclease I 3177245..3177952 Escherichia coli SMS-3-5 6147036 YP_001745107.1 CDS rsmE NC_010498.1 3178032 3178763 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3178032..3178763 Escherichia coli SMS-3-5 6146891 YP_001745108.1 CDS gshB NC_010498.1 3178776 3179726 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3178776..3179726 Escherichia coli SMS-3-5 6146371 YP_001745109.1 CDS EcSMS35_3090 NC_010498.1 3179835 3180398 D identified by match to protein family HMM PF02622; hypothetical protein 3179835..3180398 Escherichia coli SMS-3-5 6143143 YP_001745110.1 CDS EcSMS35_3091 NC_010498.1 3180398 3180814 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3180398..3180814 Escherichia coli SMS-3-5 6144840 YP_001745111.1 CDS EcSMS35_3092 NC_010498.1 3180993 3182018 R identified by match to protein family HMM PF00437; match to protein family HMM TIGR01420; twitching motility family protein complement(3180993..3182018) Escherichia coli SMS-3-5 6145936 YP_001745112.1 CDS EcSMS35_3093 NC_010498.1 3181991 3182695 D identified by match to protein family HMM PF01168; match to protein family HMM TIGR00044; alanine racemase 3181991..3182695 Escherichia coli SMS-3-5 6144562 YP_001745113.1 CDS EcSMS35_3094 NC_010498.1 3182713 3183279 D identified by match to protein family HMM PF02325; YGGT family protein 3182713..3183279 Escherichia coli SMS-3-5 6142669 YP_001745114.1 CDS EcSMS35_3095 NC_010498.1 3183276 3183566 D yggU; identified by similarity to SP:Q83JS1; match to protein family HMM PF02594; match to protein family HMM TIGR00251; hypothetical protein 3183276..3183566 Escherichia coli SMS-3-5 6143205 YP_001745115.1 CDS rdgB NC_010498.1 3183574 3184167 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3183574..3184167 Escherichia coli SMS-3-5 6146002 YP_001745116.1 CDS EcSMS35_3097 NC_010498.1 3184160 3185296 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3184160..3185296 Escherichia coli SMS-3-5 6144156 YP_001745117.1 CDS EcSMS35_3098 NC_010498.1 3185365 3186372 R identified by match to protein family HMM PF06717; hypothetical protein complement(3185365..3186372) Escherichia coli SMS-3-5 6145496 YP_001745118.1 CDS ansB NC_010498.1 3186489 3187535 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3186489..3187535) Escherichia coli SMS-3-5 6146057 YP_001745119.1 CDS EcSMS35_3100 NC_010498.1 3187711 3188430 R hypothetical protein complement(3187711..3188430) Escherichia coli SMS-3-5 6146265 YP_001745120.1 CDS EcSMS35_3101 NC_010498.1 3188451 3188591 R hypothetical protein complement(3188451..3188591) Escherichia coli SMS-3-5 6146775 YP_001745121.1 CDS EcSMS35_3102 NC_010498.1 3188614 3188940 R identified by match to protein family HMM PF04320; hypothetical protein complement(3188614..3188940) Escherichia coli SMS-3-5 6144140 YP_001745122.1 CDS trmB NC_010498.1 3188940 3189659 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3188940..3189659) Escherichia coli SMS-3-5 6146837 YP_001745123.1 CDS mutY NC_010498.1 3189820 3190872 D identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; adenine DNA glycosylase 3189820..3190872 Escherichia coli SMS-3-5 6146887 YP_001745124.1 CDS EcSMS35_3105 NC_010498.1 3190900 3191175 D identified by match to protein family HMM PF04362; hypothetical protein 3190900..3191175 Escherichia coli SMS-3-5 6147107 YP_001745125.1 CDS mltC NC_010498.1 3191239 3192318 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3191239..3192318 Escherichia coli SMS-3-5 6143122 YP_001745126.1 CDS EcSMS35_3107 NC_010498.1 3192324 3192458 R identified by Glimmer3; putative; hypothetical protein complement(3192324..3192458) Escherichia coli SMS-3-5 6147527 YP_001745127.1 CDS nupG NC_010498.1 3192520 3193776 D identified by similarity to SP:P0AFF5; match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; nucleoside permease NupG 3192520..3193776 Escherichia coli SMS-3-5 6144908 YP_001745128.1 CDS speC NC_010498.1 3193823 3195958 R identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; ornithine decarboxylase complement(3193823..3195958) Escherichia coli SMS-3-5 6143820 YP_001745129.1 CDS EcSMS35_3112 NC_010498.1 3197411 3198595 D identified by match to protein family HMM PF00589; site-specific recombinase, phage integrase family protein 3197411..3198595 Escherichia coli SMS-3-5 6143632 YP_001745130.1 CDS rafR NC_010498.1 3198745 3199755 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; HTH-type transcriptional regulator RafR 3198745..3199755 Escherichia coli SMS-3-5 6143982 YP_001745131.1 CDS rafA NC_010498.1 3199851 3201977 D identified by match to protein family HMM PF02065; alpha-galactosidase 3199851..3201977 Escherichia coli SMS-3-5 6146988 YP_001745132.1 CDS lacY NC_010498.1 3202040 3203317 D lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 3202040..3203317 Escherichia coli SMS-3-5 6146325 YP_001745133.1 CDS rafD NC_010498.1 3203317 3204747 D identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; raffinose invertase 3203317..3204747 Escherichia coli SMS-3-5 6143148 YP_001745134.1 CDS rafY1 NC_010498.1 3204942 3206336 D identified by similarity to GB:AAB71432.1; glycoporin RafY 3204942..3206336 Escherichia coli SMS-3-5 6147373 YP_001745135.1 CDS EcSMS35_3118 NC_010498.1 3206914 3207357 R identified by similarity to SP:P19777; IS2 transposase orfB complement(3206914..3207357) Escherichia coli SMS-3-5 6144884 YP_001745136.1 CDS EcSMS35_3119 NC_010498.1 3207276 3207551 R identified by match to protein family HMM PF03811; IS1 transposase orfA complement(3207276..3207551) Escherichia coli SMS-3-5 6143024 YP_001745137.1 CDS EcSMS35_3120 NC_010498.1 3207580 3207804 R hypothetical protein complement(3207580..3207804) Escherichia coli SMS-3-5 6142830 YP_001745138.1 CDS EcSMS35_3124 NC_010498.1 3210660 3211337 D identified by match to protein family HMM PF01527; IS66 family transposase orfA 3210660..3211337 Escherichia coli SMS-3-5 6146851 YP_001745139.1 CDS EcSMS35_3125 NC_010498.1 3211418 3211597 R identified by Glimmer3; putative; hypothetical protein complement(3211418..3211597) Escherichia coli SMS-3-5 6146541 YP_001745140.1 CDS EcSMS35_3126 NC_010498.1 3211704 3213278 D identified by match to protein family HMM PF03050; IS66 family transposase orfB 3211704..3213278 Escherichia coli SMS-3-5 6145603 YP_001745141.1 CDS EcSMS35_3127 NC_010498.1 3213444 3213680 R identified by Glimmer3; putative; hypothetical protein complement(3213444..3213680) Escherichia coli SMS-3-5 6142840 YP_001745142.1 CDS EcSMS35_3128 NC_010498.1 3214175 3216262 R IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein complement(3214175..3216262) Escherichia coli SMS-3-5 6144516 YP_001745143.1 CDS EcSMS35_3129 NC_010498.1 3216575 3216859 D identified by Glimmer3; putative; hypothetical protein 3216575..3216859 Escherichia coli SMS-3-5 6143541 YP_001745144.1 CDS EcSMS35_3130 NC_010498.1 3217235 3217588 D identified by Glimmer3; putative; hypothetical protein 3217235..3217588 Escherichia coli SMS-3-5 6147364 YP_001745145.1 CDS EcSMS35_3131 NC_010498.1 3218016 3219047 R identified by similarity to SP:P16943; IS630 transposase complement(3218016..3219047) Escherichia coli SMS-3-5 6142962 YP_001745146.1 CDS EcSMS35_3132 NC_010498.1 3219190 3219366 R identified by Glimmer3; putative; hypothetical protein complement(3219190..3219366) Escherichia coli SMS-3-5 6146045 YP_001745147.1 CDS EcSMS35_3136 NC_010498.1 3223179 3223529 R identified by match to protein family HMM PF05717; IS66 family transposase orfB complement(3223179..3223529) Escherichia coli SMS-3-5 6143245 YP_001745148.1 CDS EcSMS35_3137 NC_010498.1 3223526 3223951 R identified by match to protein family HMM PF01527; IS66 family transposase orfA complement(3223526..3223951) Escherichia coli SMS-3-5 6144452 YP_001745149.1 CDS amiC2 NC_010498.1 3227446 3228705 R identified by similarity to SP:P63883; match to protein family HMM PF01520; N-acetylmuramoyl-L-alanine amidase AmiC complement(3227446..3228705) Escherichia coli SMS-3-5 6144546 YP_001745150.1 CDS EcSMS35_3141 NC_010498.1 3229572 3229997 R identified by Glimmer3; putative; hypothetical protein complement(3229572..3229997) Escherichia coli SMS-3-5 6147513 YP_001745151.1 CDS EcSMS35_3143 NC_010498.1 3230570 3231313 R identified by match to protein family HMM PF01695; IS21 transposase orfB complement(3230570..3231313) Escherichia coli SMS-3-5 6143548 YP_001745152.1 CDS EcSMS35_3144 NC_010498.1 3231313 3232485 R identified by match to protein family HMM PF00665; IS2 transposase orfA complement(3231313..3232485) Escherichia coli SMS-3-5 6146122 YP_001745153.1 CDS ibrB NC_010498.1 3236889 3237533 R identified by similarity to GB:AAM53134.1; match to protein family HMM PF02195; immunoglobulin-binding regulator B complement(3236889..3237533) Escherichia coli SMS-3-5 6146769 YP_001745154.1 CDS ibrA NC_010498.1 3237518 3238744 R identified by similarity to GB:AAM53133.1; match to protein family HMM PF01507; immunoglobulin-binding regulator A complement(3237518..3238744) Escherichia coli SMS-3-5 6142771 YP_001745155.1 CDS EcSMS35_3155 NC_010498.1 3240031 3240180 R identified by Glimmer3; putative; hypothetical protein complement(3240031..3240180) Escherichia coli SMS-3-5 6146694 YP_001745156.1 CDS EcSMS35_3156 NC_010498.1 3240501 3240800 D identified by match to protein family HMM PF01527; ISEc16 transposase orfA 3240501..3240800 Escherichia coli SMS-3-5 6147161 YP_001745157.1 CDS EcSMS35_3161 NC_010498.1 3244161 3244352 D identified by Glimmer3; putative; hypothetical protein 3244161..3244352 Escherichia coli SMS-3-5 6145893 YP_001745158.1 CDS EcSMS35_3162 NC_010498.1 3245598 3245822 D identified by Glimmer3; putative; hypothetical protein 3245598..3245822 Escherichia coli SMS-3-5 6146585 YP_001745159.1 CDS sodC_2 NC_010498.1 3245951 3246475 R identified by similarity to SP:P53636; match to protein family HMM PF00080; superoxide dismutase (Cu-Zn) complement(3245951..3246475) Escherichia coli SMS-3-5 6144599 YP_001745160.1 CDS EcSMS35_3164 NC_010498.1 3246929 3247294 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3246929..3247294 Escherichia coli SMS-3-5 6144815 YP_001745161.1 CDS EcSMS35_3165 NC_010498.1 3247252 3248157 D identified by match to protein family HMM PF00665; IS2 transposase orfB 3247252..3248157 Escherichia coli SMS-3-5 6145246 YP_001745162.1 CDS EcSMS35_3166 NC_010498.1 3248142 3248258 D identified by Glimmer3; putative; hypothetical protein 3248142..3248258 Escherichia coli SMS-3-5 6143077 YP_001745163.1 CDS EcSMS35_3167 NC_010498.1 3248278 3248430 R identified by Glimmer3; putative; hypothetical protein complement(3248278..3248430) Escherichia coli SMS-3-5 6144203 YP_001745164.1 CDS sitA_2 NC_010498.1 3251173 3252087 D identified by similarity to GB:AAT11264.1; match to protein family HMM PF01297; iron/manganese transport system periplasmic binding protein SitA 3251173..3252087 Escherichia coli SMS-3-5 6144399 YP_001745165.1 CDS sitB_2 NC_010498.1 3252087 3252914 D identified by similarity to GB:AAT11265.1; match to protein family HMM PF00005; iron/manganese transport system inner membrane protein SitB 3252087..3252914 Escherichia coli SMS-3-5 6144258 YP_001745166.1 CDS sitC_2 NC_010498.1 3252911 3253768 D identified by similarity to GB:AAT11266.1; match to protein family HMM PF00950; match to protein family HMM PF01032; iron/manganese transport system inner membrane protein SitC 3252911..3253768 Escherichia coli SMS-3-5 6143531 YP_001745167.1 CDS sitD_2 NC_010498.1 3253765 3254643 D identified by similarity to GB:AAT11267.1; match to protein family HMM PF00950; iron/manganese transport system membrane protein SitD 3253765..3254643 Escherichia coli SMS-3-5 6142772 YP_001745168.1 CDS iutA NC_010498.1 3257233 3259434 R identified by similarity to SP:P14542; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; ferric aerobactin receptor IutA complement(3257233..3259434) Escherichia coli SMS-3-5 6143094 YP_001745169.1 CDS iucD NC_010498.1 3259516 3260793 R identified by similarity to SP:P11295; L-lysine 6-monooxygenase IucD complement(3259516..3260793) Escherichia coli SMS-3-5 6145117 YP_001745170.1 CDS iucC NC_010498.1 3260790 3262532 R identified by similarity to SP:Q47318; match to protein family HMM PF04183; aerobactin siderophore biosynthesis protein IucC complement(3260790..3262532) Escherichia coli SMS-3-5 6147083 YP_001745171.1 CDS iucB NC_010498.1 3262532 3263479 R identified by similarity to SP:Q47317; aerobactin siderophore biosynthesis protein IucB complement(3262532..3263479) Escherichia coli SMS-3-5 6144084 YP_001745172.1 CDS iucA NC_010498.1 3263480 3265204 R identified by similarity to SP:Q47316; match to protein family HMM PF04183; aerobactin siderophore biosynthesis protein IucA complement(3263480..3265204) Escherichia coli SMS-3-5 6145998 YP_001745173.1 CDS shiF NC_010498.1 3265340 3266533 D identified by match to protein family HMM PF07690; transport protein ShiF 3265340..3266533 Escherichia coli SMS-3-5 6142947 YP_001745174.1 CDS EcSMS35_3187 NC_010498.1 3270859 3271968 R identified by match to protein family HMM PF03895; match to protein family HMM PF05662; match to protein family HMM TIGR01409; putative immunoglobuling-binding protein complement(3270859..3271968) Escherichia coli SMS-3-5 6146755 YP_001745175.1 CDS EcSMS35_3188 NC_010498.1 3271994 3272143 R identified by Glimmer3; putative; hypothetical protein complement(3271994..3272143) Escherichia coli SMS-3-5 6146090 YP_001745176.1 CDS EcSMS35_3189 NC_010498.1 3272612 3272725 R identified by Glimmer3; putative; hypothetical protein complement(3272612..3272725) Escherichia coli SMS-3-5 6144547 YP_001745177.1 CDS EcSMS35_3190 NC_010498.1 3272848 3272967 D identified by Glimmer3; putative; hypothetical protein 3272848..3272967 Escherichia coli SMS-3-5 6144640 YP_001745178.1 CDS EcSMS35_3195 NC_010498.1 3275023 3275775 R identified by Glimmer3; putative; hypothetical protein complement(3275023..3275775) Escherichia coli SMS-3-5 6145945 YP_001745179.1 CDS EcSMS35_3196 NC_010498.1 3275772 3276008 R identified by match to protein family HMM PF05930; AlpA family transcriptional regulator complement(3275772..3276008) Escherichia coli SMS-3-5 6147145 YP_001745180.1 CDS EcSMS35_3197 NC_010498.1 3276077 3276649 R identified by Glimmer3; putative; hypothetical protein complement(3276077..3276649) Escherichia coli SMS-3-5 6144444 YP_001745181.1 CDS EcSMS35_3198 NC_010498.1 3277010 3277741 R hypothetical protein complement(3277010..3277741) Escherichia coli SMS-3-5 6143556 YP_001745182.1 CDS EcSMS35_3199 NC_010498.1 3278077 3278235 R identified by Glimmer3; putative; hypothetical protein complement(3278077..3278235) Escherichia coli SMS-3-5 6145073 YP_001745183.1 CDS EcSMS35_3200 NC_010498.1 3278337 3278456 R identified by Glimmer3; putative; hypothetical protein complement(3278337..3278456) Escherichia coli SMS-3-5 6144456 YP_001745184.1 CDS EcSMS35_3201 NC_010498.1 3279260 3280390 R identified by Glimmer3; putative; hypothetical protein complement(3279260..3280390) Escherichia coli SMS-3-5 6146418 YP_001745185.1 CDS EcSMS35_3202 NC_010498.1 3280575 3281459 D identified by match to protein family HMM PF01926; putative GTPase 3280575..3281459 Escherichia coli SMS-3-5 6145728 YP_001745186.1 CDS EcSMS35_3203 NC_010498.1 3281478 3281633 D identified by Glimmer3; putative; hypothetical protein 3281478..3281633 Escherichia coli SMS-3-5 6147242 YP_001745187.1 CDS EcSMS35_3204 NC_010498.1 3281662 3282342 D identified by match to protein family HMM PF08279; hypothetical protein 3281662..3282342 Escherichia coli SMS-3-5 6146681 YP_001745188.1 CDS EcSMS35_3205 NC_010498.1 3282385 3283167 D identified by Glimmer3; putative; hypothetical protein 3282385..3283167 Escherichia coli SMS-3-5 6143382 YP_001745189.1 CDS EcSMS35_3206 NC_010498.1 3283173 3283406 D identified by match to protein family HMM PF06006; hypothetical protein 3283173..3283406 Escherichia coli SMS-3-5 6144604 YP_001745190.1 CDS EcSMS35_3207 NC_010498.1 3283496 3284314 D identified by match to protein family HMM PF06067; hypothetical protein 3283496..3284314 Escherichia coli SMS-3-5 6145760 YP_001745191.1 CDS EcSMS35_3208 NC_010498.1 3284396 3284875 D identified by match to protein family HMM PF03230; antirestriction protein 3284396..3284875 Escherichia coli SMS-3-5 6145872 YP_001745192.1 CDS EcSMS35_3209 NC_010498.1 3284891 3285367 D identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 3284891..3285367 Escherichia coli SMS-3-5 6142822 YP_001745193.1 CDS EcSMS35_3210 NC_010498.1 3285430 3285651 D identified by match to protein family HMM PF06174; hypothetical protein 3285430..3285651 Escherichia coli SMS-3-5 6147221 YP_001745194.1 CDS EcSMS35_3211 NC_010498.1 3285851 3286105 D identified by similarity to SP:P76364; match to protein family HMM PF06154; putative antitoxin module of toxin-antitoxin system 3285851..3286105 Escherichia coli SMS-3-5 6143471 YP_001745195.1 CDS EcSMS35_3212 NC_010498.1 3286152 3286529 D identified by match to protein family HMM PF06755; hypothetical protein 3286152..3286529 Escherichia coli SMS-3-5 6147392 YP_001745196.1 CDS EcSMS35_3213 NC_010498.1 3286526 3287014 D hypothetical protein 3286526..3287014 Escherichia coli SMS-3-5 6144468 YP_001745197.1 CDS EcSMS35_3214 NC_010498.1 3287026 3287223 D identified by match to protein family HMM PF06117; hypothetical protein 3287026..3287223 Escherichia coli SMS-3-5 6143782 YP_001745198.1 CDS EcSMS35_3215 NC_010498.1 3287308 3288174 D hypothetical protein 3287308..3288174 Escherichia coli SMS-3-5 6143076 YP_001745199.1 CDS EcSMS35_3216 NC_010498.1 3288246 3288509 D identified by match to protein family HMM PF03693; match to protein family HMM TIGR02606; CC2985 family addiction module antidote protein 3288246..3288509 Escherichia coli SMS-3-5 6146892 YP_001745200.1 CDS EcSMS35_3217 NC_010498.1 3289323 3289478 D identified by Glimmer3; putative; hypothetical protein 3289323..3289478 Escherichia coli SMS-3-5 6142596 YP_001745201.1 CDS EcSMS35_3218 NC_010498.1 3289646 3289768 R identified by Glimmer3; putative; hypothetical protein complement(3289646..3289768) Escherichia coli SMS-3-5 6143123 YP_001745202.1 CDS kpsF NC_010498.1 3290253 3291272 D identified by similarity to SP:Q47334; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393; polysialic acid capsule expression protein KpsF 3290253..3291272 Escherichia coli SMS-3-5 6145537 YP_001745203.1 CDS kpsE NC_010498.1 3291344 3292492 D identified by similarity to SP:P42501; match to protein family HMM TIGR01010; polysialic acid capsule export inner-membrane protein KpsE 3291344..3292492 Escherichia coli SMS-3-5 6144874 YP_001745204.1 CDS kpsD NC_010498.1 3292516 3294192 D identified by similarity to SP:Q03961; match to protein family HMM PF02563; polysialic acid capsule transport protein KpsD 3292516..3294192 Escherichia coli SMS-3-5 6145112 YP_001745205.1 CDS kpsU NC_010498.1 3294202 3294942 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 3294202..3294942 Escherichia coli SMS-3-5 6145744 YP_001745206.1 CDS kpsC NC_010498.1 3294939 3296972 D identified by similarity to SP:P42217; match to protein family HMM PF05159; polysialic acid capsule polysaccharide export protein KpsC 3294939..3296972 Escherichia coli SMS-3-5 6144878 YP_001745207.1 CDS kpsS NC_010498.1 3296995 3298200 D identified by similarity to SP:P42218; match to protein family HMM PF05159; polysialic acid capsule biosynthesis protein KpsS 3296995..3298200 Escherichia coli SMS-3-5 6144338 YP_001745208.1 CDS neuS NC_010498.1 3299836 3301065 R identified by similarity to GB:AAA24213.1; match to protein family HMM PF07388; polysialic acid capsule biosynthesis polysialyltransferase NeuS complement(3299836..3301065) Escherichia coli SMS-3-5 6146089 YP_001745209.1 CDS neuE NC_010498.1 3301055 3302230 R identified by similarity to GB:AAY17379.1; polysialic acid capsule biosynthesis protein NeuE complement(3301055..3302230) Escherichia coli SMS-3-5 6146149 YP_001745210.1 CDS neuC NC_010498.1 3302196 3303371 R identified by similarity to SP:Q47400; match to protein family HMM PF02350; polysialic acid capsule biosynthesis protein NeuC complement(3302196..3303371) Escherichia coli SMS-3-5 6147173 YP_001745211.1 CDS neuA NC_010498.1 3303368 3304624 R identified by similarity to SP:P13266; match to protein family HMM PF02348; polysialic acid capsule biosynthesis N-acylneuraminate cytidylyltransferase NeuA complement(3303368..3304624) Escherichia coli SMS-3-5 6142885 YP_001745212.1 CDS neuB NC_010498.1 3304624 3305664 R identified by similarity to GB:AAC43302.1; match to protein family HMM PF03102; match to protein family HMM PF08666; polysialic acid capsule biosynthesis sialic acid synthase NeuB complement(3304624..3305664) Escherichia coli SMS-3-5 6142759 YP_001745213.1 CDS neuD NC_010498.1 3305661 3306284 R identified by similarity to GB:AAC43301.1; polysialic acid capsule biosynthesis protein NeuD complement(3305661..3306284) Escherichia coli SMS-3-5 6143421 YP_001745214.1 CDS kpsT NC_010498.1 3306334 3306993 R identified by similarity to SP:P23888; match to protein family HMM PF00005; polysialic acid capsule biosynthesis transport protein KpsT complement(3306334..3306993) Escherichia coli SMS-3-5 6143906 YP_001745215.1 CDS kpsM NC_010498.1 3306990 3307766 R identified by similarity to SP:P23889; match to protein family HMM PF01061; polysialic acid capsule biosynthesis transport protein KpsM complement(3306990..3307766) Escherichia coli SMS-3-5 6144510 YP_001745216.1 CDS EcSMS35_3236 NC_010498.1 3308800 3309999 R identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766; IS200 transposase orfB complement(3308800..3309999) Escherichia coli SMS-3-5 6145201 YP_001745217.1 CDS EcSMS35_3237 NC_010498.1 3310058 3310462 D identified by match to protein family HMM PF01797; IS200 transposase orfA 3310058..3310462 Escherichia coli SMS-3-5 6146592 YP_001745218.1 CDS gspM NC_010498.1 3310702 3311238 R identified by similarity to SP:Q46832; match to protein family HMM PF04612; putative general secretion pathway protein YghD complement(3310702..3311238) Escherichia coli SMS-3-5 6147414 YP_001745219.1 CDS gspL NC_010498.1 3311240 3312418 R similar to general secretory pathway protein L; GspL-like protein complement(3311240..3312418) Escherichia coli SMS-3-5 6147096 YP_001745220.1 CDS gspK NC_010498.1 3312415 3313392 R identified by similarity to GB:AAL10700.1; match to protein family HMM PF03934; general secretion pathway protein GspK complement(3312415..3313392) Escherichia coli SMS-3-5 6142677 YP_001745221.1 CDS gspJ NC_010498.1 3313392 3313997 R identified by similarity to GB:AAL60190.1; match to protein family HMM TIGR01711; general secretion pathway protein GspJ complement(3313392..3313997) Escherichia coli SMS-3-5 6143491 YP_001745222.1 CDS gspI NC_010498.1 3313994 3314365 R identified by similarity to GB:AAL60189.1; match to protein family HMM PF02501; match to protein family HMM PF07963; match to protein family HMM TIGR01707; match to protein family HMM TIGR02532; general secretion pathway protein GspI complement(3313994..3314365) Escherichia coli SMS-3-5 6144131 YP_001745223.1 CDS gspH NC_010498.1 3314362 3314925 R identified by similarity to GB:AAL60188.1; match to protein family HMM PF07963; match to protein family HMM TIGR02532; general secretion pathway protein GspH complement(3314362..3314925) Escherichia coli SMS-3-5 6143893 YP_001745224.1 CDS gspG NC_010498.1 3314929 3315384 R identified by similarity to GB:AAL60187.1; match to protein family HMM PF07963; match to protein family HMM PF08334; match to protein family HMM TIGR01710; match to protein family HMM TIGR02532; general secretion pathway protein GspG complement(3314929..3315384) Escherichia coli SMS-3-5 6145458 YP_001745225.1 CDS gspF NC_010498.1 3315401 3316624 R identified by similarity to GB:AAL60186.1; match to protein family HMM PF00482; match to protein family HMM TIGR02120; general secretion pathway protein GspF complement(3315401..3316624) Escherichia coli SMS-3-5 6145182 YP_001745226.1 CDS gspE NC_010498.1 3316624 3318117 R identified by similarity to GB:AAL60185.1; match to protein family HMM PF00437; match to protein family HMM TIGR02533; general secretory pathway protein GspE complement(3316624..3318117) Escherichia coli SMS-3-5 6145654 YP_001745227.1 CDS gspD NC_010498.1 3318117 3320177 R identified by similarity to GB:AAL60184.1; match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM TIGR02517; general secretion pathway protein GspD complement(3318117..3320177) Escherichia coli SMS-3-5 6142627 YP_001745228.1 CDS gspC NC_010498.1 3320207 3321166 R part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC complement(3320207..3321166) Escherichia coli SMS-3-5 6145363 YP_001745229.1 CDS EcSMS35_3249 NC_010498.1 3321184 3321594 R putative lipoprotein complement(3321184..3321594) Escherichia coli SMS-3-5 6145303 YP_001745230.1 CDS pppA NC_010498.1 3321660 3322469 R identified by similarity to GB:AAL60181.1; match to protein family HMM PF01478; match to protein family HMM PF06750; leader peptidase PppA complement(3321660..3322469) Escherichia coli SMS-3-5 6144751 YP_001745231.1 CDS EcSMS35_3251 NC_010498.1 3322667 3327223 R hypothetical protein complement(3322667..3327223) Escherichia coli SMS-3-5 6144240 YP_001745232.1 CDS glcA NC_010498.1 3327708 3329390 R identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795; glycolate transporter complement(3327708..3329390) Escherichia coli SMS-3-5 6147335 YP_001745233.1 CDS glcB NC_010498.1 3329745 3331916 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3329745..3331916) Escherichia coli SMS-3-5 6146304 YP_001745234.1 CDS EcSMS35_3254 NC_010498.1 3331938 3332342 R identified by match to protein family HMM PF03928; hypothetical protein complement(3331938..3332342) Escherichia coli SMS-3-5 6145956 YP_001745235.1 CDS glcF NC_010498.1 3332347 3333570 R identified by match to protein family HMM PF00037; match to protein family HMM PF02754; glycolate oxidase iron-sulfur subunit complement(3332347..3333570) Escherichia coli SMS-3-5 6145300 YP_001745236.1 CDS glcE NC_010498.1 3333581 3334633 R identified by match to protein family HMM PF01565; glycolate oxidase FAD binding subunit complement(3333581..3334633) Escherichia coli SMS-3-5 6145019 YP_001745237.1 CDS glcD NC_010498.1 3334633 3336123 R identified by match to protein family HMM PF01565; match to protein family HMM PF02913; match to protein family HMM TIGR00387; glycolate oxidase subunit GlcD complement(3334633..3336123) Escherichia coli SMS-3-5 6146214 YP_001745238.1 CDS glcC NC_010498.1 3336383 3337153 D identified by similarity to SP:P0ACL5; match to protein family HMM PF00392; match to protein family HMM PF07729; DNA-binding transcriptional regulator GlcC 3336383..3337153 Escherichia coli SMS-3-5 6146760 YP_001745239.1 CDS EcSMS35_3259 NC_010498.1 3337229 3338371 R identified by Glimmer3; putative; hypothetical protein complement(3337229..3338371) Escherichia coli SMS-3-5 6142637 YP_001745240.1 CDS EcSMS35_3260 NC_010498.1 3338775 3340466 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3338775..3340466 Escherichia coli SMS-3-5 6143153 YP_001745241.1 CDS EcSMS35_3261 NC_010498.1 3340463 3341377 D identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368; match to protein family HMM PF07993; NAD dependent epimerase/dehydratase family protein 3340463..3341377 Escherichia coli SMS-3-5 6143318 YP_001745242.1 CDS EcSMS35_3262 NC_010498.1 3341409 3341657 D identified by match to protein family HMM PF00550; putative acyl carrier protein 3341409..3341657 Escherichia coli SMS-3-5 6144275 YP_001745243.1 CDS EcSMS35_3263 NC_010498.1 3341657 3342829 D identified by match to protein family HMM PF00155; match to protein family HMM PF00202; putative serine palmitoyltransferase 3341657..3342829 Escherichia coli SMS-3-5 6144797 YP_001745244.1 CDS EcSMS35_3264 NC_010498.1 3342864 3343943 R identified by match to protein family HMM PF03739; YjgP/YjgQ permease complement(3342864..3343943) Escherichia coli SMS-3-5 6144368 YP_001745245.1 CDS EcSMS35_3265 NC_010498.1 3343940 3345010 R identified by match to protein family HMM PF03739; YjgP/YjgQ permease complement(3343940..3345010) Escherichia coli SMS-3-5 6145542 YP_001745246.1 CDS EcSMS35_3266 NC_010498.1 3345041 3345601 R ytfJ; identified by match to protein family HMM TIGR01626; hypothetical protein complement(3345041..3345601) Escherichia coli SMS-3-5 6143160 YP_001745247.1 CDS EcSMS35_3267 NC_010498.1 3345613 3346437 R identified by similarity to GB:AAP18318.1; hypothetical protein complement(3345613..3346437) Escherichia coli SMS-3-5 6147125 YP_001745248.1 CDS EcSMS35_3268 NC_010498.1 3346437 3347786 R identified by match to protein family HMM PF01943; putative polysaccharide biosynthesis protein complement(3346437..3347786) Escherichia coli SMS-3-5 6146758 YP_001745249.1 CDS EcSMS35_3269 NC_010498.1 3347832 3348590 R hypothetical protein complement(3347832..3348590) Escherichia coli SMS-3-5 6146120 YP_001745250.1 CDS EcSMS35_3270 NC_010498.1 3348622 3349320 R putative lipoprotein complement(3348622..3349320) Escherichia coli SMS-3-5 6146075 YP_001745251.1 CDS EcSMS35_3271 NC_010498.1 3349509 3350201 D hypothetical protein 3349509..3350201 Escherichia coli SMS-3-5 6145419 YP_001745252.1 CDS pitB NC_010498.1 3350250 3351749 R identified by match to protein family HMM PF01384; low-affinity inorganic phosphate transporter 2 complement(3350250..3351749) Escherichia coli SMS-3-5 6144750 YP_001745253.1 CDS EcSMS35_3273 NC_010498.1 3351809 3351949 D identified by Glimmer3; putative; hypothetical protein 3351809..3351949 Escherichia coli SMS-3-5 6144285 YP_001745254.1 CDS gsp NC_010498.1 3352041 3353900 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3352041..3353900) Escherichia coli SMS-3-5 6146094 YP_001745255.1 CDS EcSMS35_3275 NC_010498.1 3354105 3354971 D YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3354105..3354971 Escherichia coli SMS-3-5 6145440 YP_001745256.1 CDS hybG NC_010498.1 3355041 3355289 R identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074; hydrogenase 2 accessory protein HypG complement(3355041..3355289) Escherichia coli SMS-3-5 6142874 YP_001745257.1 CDS hypA1 NC_010498.1 3355302 3355643 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3355302..3355643) Escherichia coli SMS-3-5 6147291 YP_001745258.1 CDS hybE NC_010498.1 3355636 3356124 R hydrogenase 2-specific chaperone complement(3355636..3356124) Escherichia coli SMS-3-5 6146130 YP_001745259.1 CDS hybD NC_010498.1 3356117 3356611 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3356117..3356611) Escherichia coli SMS-3-5 6146713 YP_001745260.1 CDS hybC NC_010498.1 3356611 3358314 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3356611..3358314) Escherichia coli SMS-3-5 6145135 YP_001745261.1 CDS hybB NC_010498.1 3358311 3359489 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit complement(3358311..3359489) Escherichia coli SMS-3-5 6144333 YP_001745262.1 CDS hybA NC_010498.1 3359479 3360465 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3359479..3360465) Escherichia coli SMS-3-5 6144588 YP_001745263.1 CDS hyb0 NC_010498.1 3360468 3361586 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3360468..3361586) Escherichia coli SMS-3-5 6143950 YP_001745264.1 CDS EcSMS35_3284 NC_010498.1 3361570 3361698 D identified by Glimmer3; putative; hypothetical protein 3361570..3361698 Escherichia coli SMS-3-5 6143389 YP_001745265.1 CDS EcSMS35_3285 NC_010498.1 3361775 3362062 R hypothetical protein complement(3361775..3362062) Escherichia coli SMS-3-5 6142716 YP_001745266.1 CDS EcSMS35_3286 NC_010498.1 3362181 3363068 R yghX; identified by match to protein family HMM PF01738; match to protein family HMM PF08840; dienelactone hydrolase family protein complement(3362181..3363068) Escherichia coli SMS-3-5 6142969 YP_001745267.1 CDS EcSMS35_3287 NC_010498.1 3363225 3364265 D identified by match to protein family HMM PF00248; aldo-keto reductase 3363225..3364265 Escherichia coli SMS-3-5 6143573 YP_001745268.1 CDS EcSMS35_3288 NC_010498.1 3364305 3364799 R identified by match to protein family HMM PF03350; match to protein family HMM TIGR00645; hypothetical protein complement(3364305..3364799) Escherichia coli SMS-3-5 6146580 YP_001745269.1 CDS EcSMS35_3289 NC_010498.1 3364990 3365874 D identified by match to protein family HMM PF00106; oxidoreductase 3364990..3365874 Escherichia coli SMS-3-5 6147109 YP_001745270.1 CDS exbD NC_010498.1 3365912 3366337 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3365912..3366337) Escherichia coli SMS-3-5 6142922 YP_001745271.1 CDS exbB NC_010498.1 3366344 3367078 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3366344..3367078) Escherichia coli SMS-3-5 6145950 YP_001745272.1 CDS metC NC_010498.1 3367330 3368517 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3367330..3368517 Escherichia coli SMS-3-5 6144171 YP_001745273.1 CDS EcSMS35_3293 NC_010498.1 3368657 3369316 D identified by match to protein family HMM PF09335; hypothetical protein 3368657..3369316 Escherichia coli SMS-3-5 6144865 YP_001745274.1 CDS EcSMS35_3294 NC_010498.1 3369356 3370255 R identified by match to protein family HMM PF00165; match to protein family HMM PF06719; AraC family transcriptional regulator complement(3369356..3370255) Escherichia coli SMS-3-5 6147369 YP_001745275.1 CDS EcSMS35_3295 NC_010498.1 3370252 3370398 R identified by Glimmer3; putative; hypothetical protein complement(3370252..3370398) Escherichia coli SMS-3-5 6143079 YP_001745276.1 CDS yqhD NC_010498.1 3370449 3371612 D identified by match to protein family HMM PF00465; alcohol dehydrogenase yqhD 3370449..3371612 Escherichia coli SMS-3-5 6143233 YP_001745277.1 CDS dkgA NC_010498.1 3371717 3372544 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3371717..3372544 Escherichia coli SMS-3-5 6146276 YP_001745278.1 CDS EcSMS35_3298 NC_010498.1 3372744 3373670 D identified by Glimmer3; putative; hypothetical protein 3372744..3373670 Escherichia coli SMS-3-5 6146804 YP_001745279.1 CDS EcSMS35_3299 NC_010498.1 3373721 3373978 D putative outer membrane lipoprotein 3373721..3373978 Escherichia coli SMS-3-5 6144947 YP_001745280.1 CDS EcSMS35_3300 NC_010498.1 3374020 3376239 R identified by match to protein family HMM PF04055; match to protein family HMM PF08497; hypothetical protein complement(3374020..3376239) Escherichia coli SMS-3-5 6145481 YP_001745281.1 CDS EcSMS35_3301 NC_010498.1 3376491 3377240 D identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 3376491..3377240 Escherichia coli SMS-3-5 6146013 YP_001745282.1 CDS EcSMS35_3302 NC_010498.1 3377563 3379035 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase 3377563..3379035 Escherichia coli SMS-3-5 6143607 YP_001745283.1 CDS EcSMS35_3303 NC_010498.1 3379032 3380048 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family protein 3379032..3380048 Escherichia coli SMS-3-5 6142919 YP_001745284.1 CDS EcSMS35_3304 NC_010498.1 3380059 3381069 D identified by match to protein family HMM PF02615; malate/L-lactate dehydrogenase family protein 3380059..3381069 Escherichia coli SMS-3-5 6147435 YP_001745285.1 CDS EcSMS35_3305 NC_010498.1 3381142 3382125 D identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein 3381142..3382125 Escherichia coli SMS-3-5 6144329 YP_001745286.1 CDS EcSMS35_3307 NC_010498.1 3382660 3383964 D identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter, DctM subunit 3382660..3383964 Escherichia coli SMS-3-5 6147460 YP_001745287.1 CDS sufI NC_010498.1 3384035 3385447 R identified by match to protein family HMM PF07731; match to protein family HMM PF07732; match to protein family HMM TIGR01409; repressor protein for FtsI complement(3384035..3385447) Escherichia coli SMS-3-5 6146929 YP_001745288.1 CDS plsC NC_010498.1 3385522 3386259 R identified by match to protein family HMM PF01553; match to protein family HMM TIGR00530; 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3385522..3386259) Escherichia coli SMS-3-5 6146355 YP_001745289.1 CDS parC NC_010498.1 3386493 3388751 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3386493..3388751) Escherichia coli SMS-3-5 6145863 YP_001745290.1 CDS EcSMS35_3311 NC_010498.1 3388889 3390496 R YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; putative binding protein complement(3388889..3390496) Escherichia coli SMS-3-5 6145653 YP_001745291.1 CDS EcSMS35_3312 NC_010498.1 3390605 3391087 R identified by match to protein family HMM PF06445; transcription activator effector binding domain/DNA gyrase inhibitor domain-containing protein complement(3390605..3391087) Escherichia coli SMS-3-5 6144799 YP_001745292.1 CDS EcSMS35_3313 NC_010498.1 3391140 3391532 R ygiW; identified by similarity to SP:P0ADU5; match to protein family HMM PF04076; match to protein family HMM TIGR00156; hypothetical protein complement(3391140..3391532) Escherichia coli SMS-3-5 6144144 YP_001745293.1 CDS qseB NC_010498.1 3391684 3392343 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3391684..3392343 Escherichia coli SMS-3-5 6146322 YP_001745294.1 CDS qseC NC_010498.1 3392340 3393689 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein QseC 3392340..3393689 Escherichia coli SMS-3-5 6143276 YP_001745295.1 CDS mdaB NC_010498.1 3393799 3394380 D identified by match to protein family HMM PF02525; modulator of drug activity B 3393799..3394380 Escherichia coli SMS-3-5 6146248 YP_001745296.1 CDS ygiN NC_010498.1 3394411 3394725 D identified by match to protein family HMM PF03992; quinol monooxygenase YgiN 3394411..3394725 Escherichia coli SMS-3-5 6146780 YP_001745297.1 CDS fitR NC_010498.1 3394770 3395657 R identified by similarity to GB:AAN82214.1; match to protein family HMM PF01380; match to protein family HMM PF01418; iron transport system regulatory protein FitR complement(3394770..3395657) Escherichia coli SMS-3-5 6145974 YP_001745298.1 CDS fitE NC_010498.1 3395654 3396601 R identified by match to protein family HMM PF01497; iron ABC transporter periplasmic iron-binding protein FitE complement(3395654..3396601) Escherichia coli SMS-3-5 6145460 YP_001745299.1 CDS fitD NC_010498.1 3396612 3397661 R identified by similarity to GB:ABI52625.1; match to protein family HMM PF01032; iron ABC transporter permease FitD complement(3396612..3397661) Escherichia coli SMS-3-5 6146185 YP_001745300.1 CDS fitC NC_010498.1 3397658 3398641 R identified by match to protein family HMM PF01032; iron ABC transporter permease FitC complement(3397658..3398641) Escherichia coli SMS-3-5 6143127 YP_001745301.1 CDS fitB NC_010498.1 3398638 3399447 R identified by similarity to GB:ABI52623.1; match to protein family HMM PF00005; iron ABC transporter ATP binding protein FitB complement(3398638..3399447) Escherichia coli SMS-3-5 6147505 YP_001745302.1 CDS EcSMS35_3323 NC_010498.1 3399527 3399646 R identified by Glimmer3; putative; hypothetical protein complement(3399527..3399646) Escherichia coli SMS-3-5 6144577 YP_001745303.1 CDS fitA NC_010498.1 3399821 3401962 D identified by similarity to GB:ABI52622.1; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; TonB-dependent outer membrane ferric coprogen receptor FitA 3399821..3401962 Escherichia coli SMS-3-5 6144067 YP_001745304.1 CDS parE NC_010498.1 3402026 3403918 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3402026..3403918) Escherichia coli SMS-3-5 6146043 YP_001745305.1 CDS yqiA NC_010498.1 3403947 3404528 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA complement(3403947..3404528) Escherichia coli SMS-3-5 6143861 YP_001745306.1 CDS icc NC_010498.1 3404528 3405355 R identified by match to protein family HMM PF00149; match to protein family HMM PF08413; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3404528..3405355) Escherichia coli SMS-3-5 6143520 YP_001745307.1 CDS EcSMS35_3328 NC_010498.1 3405380 3405802 R identified by match to protein family HMM PF06853; hypothetical protein complement(3405380..3405802) Escherichia coli SMS-3-5 6142682 YP_001745308.1 CDS nudF NC_010498.1 3405803 3406432 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF complement(3405803..3406432) Escherichia coli SMS-3-5 6146792 YP_001745309.1 CDS tolC NC_010498.1 3406637 3408118 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3406637..3408118 Escherichia coli SMS-3-5 6142633 YP_001745310.1 CDS EcSMS35_3331 NC_010498.1 3408266 3408937 D hypothetical protein 3408266..3408937 Escherichia coli SMS-3-5 6146746 YP_001745311.1 CDS EcSMS35_3332 NC_010498.1 3408943 3410103 D identified by match to protein family HMM PF03738; glutathionylspermidine synthase family protein 3408943..3410103 Escherichia coli SMS-3-5 6145912 YP_001745312.1 CDS EcSMS35_3333 NC_010498.1 3410588 3412384 D identified by match to protein family HMM PF05935; arylsulfate sulfotransferase 3410588..3412384 Escherichia coli SMS-3-5 6145661 YP_001745313.1 CDS EcSMS35_3334 NC_010498.1 3412402 3413070 D identified by similarity to SP:P0AEG4; match to protein family HMM PF01323; DsbA family thioredoxin 3412402..3413070 Escherichia coli SMS-3-5 6144198 YP_001745314.1 CDS EcSMS35_3335 NC_010498.1 3413100 3413756 D putative disulfide oxidoreductase 3413100..3413756 Escherichia coli SMS-3-5 6145881 YP_001745315.1 CDS EcSMS35_3336 NC_010498.1 3413802 3414590 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3413802..3414590) Escherichia coli SMS-3-5 6145463 YP_001745316.1 CDS zupT NC_010498.1 3414733 3415506 D identified by match to protein family HMM PF02535; zinc transporter ZupT 3414733..3415506 Escherichia coli SMS-3-5 6144645 YP_001745317.1 CDS EcSMS35_3338 NC_010498.1 3415564 3415758 R hypothetical protein complement(3415564..3415758) Escherichia coli SMS-3-5 6144076 YP_001745318.1 CDS ribB NC_010498.1 3415996 3416649 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3415996..3416649) Escherichia coli SMS-3-5 6143765 YP_001745319.1 CDS EcSMS35_3340 NC_010498.1 3416963 3417322 D yqiC; identified by match to protein family HMM PF04380; hypothetical protein 3416963..3417322 Escherichia coli SMS-3-5 6143265 YP_001745320.1 CDS glgS NC_010498.1 3417357 3417557 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3417357..3417557) Escherichia coli SMS-3-5 6143593 YP_001745321.1 CDS EcSMS35_3342 NC_010498.1 3417826 3418455 D identified by match to protein family HMM PF07290; putative inner membrane protein 3417826..3418455 Escherichia coli SMS-3-5 6142898 YP_001745322.1 CDS EcSMS35_3343 NC_010498.1 3418482 3420143 D identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein 3418482..3420143 Escherichia coli SMS-3-5 6146458 YP_001745323.1 CDS hldE NC_010498.1 3420937 3422370 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3420937..3422370) Escherichia coli SMS-3-5 6145779 YP_001745324.1 CDS glnE NC_010498.1 3422418 3425258 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3422418..3425258) Escherichia coli SMS-3-5 6143035 YP_001745325.1 CDS EcSMS35_3346 NC_010498.1 3425281 3426582 R identified by match to protein family HMM PF01928; match to protein family HMM PF05235; adenylate cyclase complement(3425281..3426582) Escherichia coli SMS-3-5 6145044 YP_001745326.1 CDS EcSMS35_3347 NC_010498.1 3426599 3426784 R identified by Glimmer3; putative; hypothetical protein complement(3426599..3426784) Escherichia coli SMS-3-5 6146949 YP_001745327.1 CDS EcSMS35_3348 NC_010498.1 3426824 3427444 D putative signal transduction protein 3426824..3427444 Escherichia coli SMS-3-5 6145821 YP_001745328.1 CDS cca NC_010498.1 3427508 3428746 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3427508..3428746 Escherichia coli SMS-3-5 6145298 YP_001745329.1 CDS bacA NC_010498.1 3428827 3429639 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3428827..3429639) Escherichia coli SMS-3-5 6144816 YP_001745330.1 CDS folB NC_010498.1 3429739 3430107 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3429739..3430107) Escherichia coli SMS-3-5 6144279 YP_001745331.1 CDS EcSMS35_3352 NC_010498.1 3430212 3430829 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3430212..3430829 Escherichia coli SMS-3-5 6143099 YP_001745332.1 CDS ttdR NC_010498.1 3430842 3431774 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(3430842..3431774) Escherichia coli SMS-3-5 6142651 YP_001745333.1 CDS ddtA NC_010498.1 3431981 3432892 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3431981..3432892 Escherichia coli SMS-3-5 6146886 YP_001745334.1 CDS ttdB NC_010498.1 3432889 3433494 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3432889..3433494 Escherichia coli SMS-3-5 6147318 YP_001745335.1 CDS EcSMS35_3356 NC_010498.1 3433542 3435005 D identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; anion transporter 3433542..3435005 Escherichia coli SMS-3-5 6142707 YP_001745336.1 CDS gcp NC_010498.1 3435048 3436061 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(3435048..3436061) Escherichia coli SMS-3-5 6145887 YP_001745337.1 CDS rpsU NC_010498.1 3436299 3436514 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3436299..3436514 Escherichia coli SMS-3-5 6146405 YP_001745338.1 CDS dnaG NC_010498.1 3436625 3438370 D synthesizes RNA primers at the replication forks; DNA primase 3436625..3438370 Escherichia coli SMS-3-5 6144369 YP_001745339.1 CDS rpoD NC_010498.1 3438565 3440406 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3438565..3440406 Escherichia coli SMS-3-5 6145062 YP_001745340.1 CDS EcSMS35_3361 NC_010498.1 3440465 3441028 D identified by match to protein family HMM PF08719; match to protein family HMM TIGR02464; hypothetical protein 3440465..3441028 Escherichia coli SMS-3-5 6142869 YP_001745341.1 CDS mug NC_010498.1 3441085 3441591 R identified by similarity to SP:P0A9H1; match to protein family HMM PF03167; G/U mismatch-specific DNA glycosylase complement(3441085..3441591) Escherichia coli SMS-3-5 6143567 YP_001745342.1 CDS EcSMS35_3364 NC_010498.1 3441845 3442609 R identified by match to protein family HMM PF04954; match to protein family HMM PF08021; siderophore-interacting protein complement(3441845..3442609) Escherichia coli SMS-3-5 6143644 YP_001745343.1 CDS EcSMS35_3365 NC_010498.1 3442896 3443519 D identified by match to protein family HMM PF03551; PadR family transcriptional regulator 3442896..3443519 Escherichia coli SMS-3-5 6146889 YP_001745344.1 CDS aer NC_010498.1 3443548 3445068 R identified by similarity to SP:P50466; match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF08447; match to protein family HMM TIGR00229; aerotaxis receptor complement(3443548..3445068) Escherichia coli SMS-3-5 6144311 YP_001745345.1 CDS ygjG NC_010498.1 3445576 3446865 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3445576..3446865 Escherichia coli SMS-3-5 6146995 YP_001745346.1 CDS EcSMS35_3368 NC_010498.1 3446907 3447239 R identified by match to protein family HMM PF01588; hypothetical protein complement(3446907..3447239) Escherichia coli SMS-3-5 6145348 YP_001745347.1 CDS ebgR NC_010498.1 3447457 3448440 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; DNA-binding transcriptional repressor EbgR 3447457..3448440 Escherichia coli SMS-3-5 6146144 YP_001745348.1 CDS ebgA NC_010498.1 3448624 3451716 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3448624..3451716 Escherichia coli SMS-3-5 6146970 YP_001745349.1 CDS ebgC NC_010498.1 3451713 3452162 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3451713..3452162 Escherichia coli SMS-3-5 6144790 YP_001745350.1 CDS EcSMS35_3372 NC_010498.1 3452225 3453658 D identified by match to protein family HMM PF00324; amino acid permease family protein 3452225..3453658 Escherichia coli SMS-3-5 6143075 YP_001745351.1 CDS EcSMS35_3373 NC_010498.1 3453792 3454862 D hypothetical protein 3453792..3454862 Escherichia coli SMS-3-5 6144070 YP_001745352.1 CDS EcSMS35_3374 NC_010498.1 3454879 3457230 D putative glycosyl hydrolase 3454879..3457230 Escherichia coli SMS-3-5 6144723 YP_001745353.1 CDS fadH NC_010498.1 3457401 3459419 D identified by match to protein family HMM PF00724; match to protein family HMM PF01266; match to protein family HMM PF07992; 2,4-dienoyl-CoA reductase 3457401..3459419 Escherichia coli SMS-3-5 6145339 YP_001745354.1 CDS EcSMS35_3376 NC_010498.1 3459537 3460673 R identified by match to protein family HMM PF05175; match to protein family HMM PF08242; methyltransferase family protein complement(3459537..3460673) Escherichia coli SMS-3-5 6143975 YP_001745355.1 CDS EcSMS35_3377 NC_010498.1 3460758 3461261 D identified by match to protein family HMM PF01863; hypothetical protein 3460758..3461261 Escherichia coli SMS-3-5 6143379 YP_001745356.1 CDS EcSMS35_3378 NC_010498.1 3461338 3462021 D identified by match to protein family HMM PF02698; putative SanA protein 3461338..3462021 Escherichia coli SMS-3-5 6142846 YP_001745357.1 CDS EcSMS35_3379 NC_010498.1 3462100 3463086 D identified by match to protein family HMM PF01408; match to protein family HMM PF02894; oxidoreductase, NAD binding 3462100..3463086 Escherichia coli SMS-3-5 6146231 YP_001745358.1 CDS alx NC_010498.1 3463370 3464335 D identified by match to protein family HMM PF03741; protein Alx 3463370..3464335 Escherichia coli SMS-3-5 6146615 YP_001745359.1 CDS sstT NC_010498.1 3464659 3465903 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3464659..3465903 Escherichia coli SMS-3-5 6146073 YP_001745360.1 CDS EcSMS35_3382 NC_010498.1 3465907 3466458 R putative inner membrane protein complement(3465907..3466458) Escherichia coli SMS-3-5 6145400 YP_001745361.1 CDS uxaA NC_010498.1 3466541 3468028 R identified by match to protein family HMM PF04295; match to protein family HMM PF08666; altronate dehydratase complement(3466541..3468028) Escherichia coli SMS-3-5 6144124 YP_001745362.1 CDS uxaC NC_010498.1 3468043 3469455 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3468043..3469455) Escherichia coli SMS-3-5 6146085 YP_001745363.1 CDS exuT NC_010498.1 3469938 3471236 D identified by similarity to SP:P0AA78; match to protein family HMM PF07690; match to protein family HMM TIGR00893; hexuronate transporter 3469938..3471236 Escherichia coli SMS-3-5 6142629 YP_001745364.1 CDS EcSMS35_3386 NC_010498.1 3471312 3472406 R identified by match to protein family HMM PF07434; pilus biogenesis initiator complement(3471312..3472406) Escherichia coli SMS-3-5 6143195 YP_001745365.1 CDS EcSMS35_3387 NC_010498.1 3472403 3475087 R hypothetical protein complement(3472403..3475087) Escherichia coli SMS-3-5 6143432 YP_001745366.1 CDS EcSMS35_3388 NC_010498.1 3475178 3475678 R identified by match to protein family HMM PF04449; CS1 type fimbrial major subunit complement(3475178..3475678) Escherichia coli SMS-3-5 6146465 YP_001745367.1 CDS EcSMS35_3389 NC_010498.1 3475708 3476424 R identified by similarity to SP:P25732; putative CFA/I fimbrial subunit A complement(3475708..3476424) Escherichia coli SMS-3-5 6147234 YP_001745368.1 CDS EcSMS35_3390 NC_010498.1 3476504 3476632 R identified by Glimmer3; putative; hypothetical protein complement(3476504..3476632) Escherichia coli SMS-3-5 6146016 YP_001745369.1 CDS exuR NC_010498.1 3476714 3477490 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3476714..3477490 Escherichia coli SMS-3-5 6146241 YP_001745370.1 CDS EcSMS35_3392 NC_010498.1 3477676 3477792 R identified by Glimmer3; putative; hypothetical protein complement(3477676..3477792) Escherichia coli SMS-3-5 6144531 YP_001745371.1 CDS EcSMS35_3393 NC_010498.1 3477835 3478497 D identified by match to protein family HMM PF09335; putative inner membrane protein 3477835..3478497 Escherichia coli SMS-3-5 6145188 YP_001745372.1 CDS EcSMS35_3394 NC_010498.1 3478516 3478884 D hypothetical protein 3478516..3478884 Escherichia coli SMS-3-5 6143406 YP_001745373.1 CDS EcSMS35_3395 NC_010498.1 3479031 3479399 D identified by match to protein family HMM PF06476; hypothetical protein 3479031..3479399 Escherichia coli SMS-3-5 6144533 YP_001745374.1 CDS EcSMS35_3396 NC_010498.1 3479437 3479742 D identified by match to protein family HMM PF05957; hypothetical protein 3479437..3479742 Escherichia coli SMS-3-5 6144440 YP_001745375.1 CDS EcSMS35_3397 NC_010498.1 3479745 3480149 D hypothetical protein 3479745..3480149 Escherichia coli SMS-3-5 6146037 YP_001745376.1 CDS EcSMS35_3398 NC_010498.1 3480139 3480438 D hypothetical protein 3480139..3480438 Escherichia coli SMS-3-5 6142979 YP_001745377.1 CDS EcSMS35_3399 NC_010498.1 3480534 3481016 D identified by match to protein family HMM PF07681; putative inner membrane protein YqjF 3480534..3481016 Escherichia coli SMS-3-5 6144664 YP_001745378.1 CDS EcSMS35_3400 NC_010498.1 3481264 3482250 D hypothetical protein 3481264..3482250 Escherichia coli SMS-3-5 6147101 YP_001745379.1 CDS EcSMS35_3401 NC_010498.1 3482533 3482898 D identified by match to protein family HMM PF05656; putative inner membrane protein YhaH 3482533..3482898 Escherichia coli SMS-3-5 6146282 YP_001745380.1 CDS EcSMS35_3402 NC_010498.1 3483140 3483496 D identified by match to protein family HMM PF05656; putative inner membrane protein 3483140..3483496 Escherichia coli SMS-3-5 6145719 YP_001745381.1 CDS EcSMS35_3403 NC_010498.1 3483547 3484443 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(3483547..3484443) Escherichia coli SMS-3-5 6144979 YP_001745382.1 CDS EcSMS35_3404 NC_010498.1 3484548 3485249 D identified by match to protein family HMM PF02678; pirin family protein 3484548..3485249 Escherichia coli SMS-3-5 6143794 YP_001745383.1 CDS EcSMS35_3405 NC_010498.1 3485269 3485436 D hypothetical protein 3485269..3485436 Escherichia coli SMS-3-5 6145735 YP_001745384.1 CDS EcSMS35_3406 NC_010498.1 3485569 3486879 R identified by match to protein family HMM PF06354; hypothetical protein complement(3485569..3486879) Escherichia coli SMS-3-5 6145506 YP_001745385.1 CDS EcSMS35_3407 NC_010498.1 3486907 3488238 R identified by match to protein family HMM TIGR00814; serine transporter family protein complement(3486907..3488238) Escherichia coli SMS-3-5 6146010 YP_001745386.1 CDS tdcG NC_010498.1 3488513 3489883 R identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase TdcG complement(3488513..3489883) Escherichia coli SMS-3-5 6144161 YP_001745387.1 CDS EcSMS35_3409 NC_010498.1 3489949 3490338 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; hypothetical protein complement(3489949..3490338) Escherichia coli SMS-3-5 6144625 YP_001745388.1 CDS pflB1 NC_010498.1 3490352 3492646 R identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase complement(3490352..3492646) Escherichia coli SMS-3-5 6144961 YP_001745389.1 CDS tdcD NC_010498.1 3492680 3493888 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3492680..3493888) Escherichia coli SMS-3-5 6145680 YP_001745390.1 CDS tdcC NC_010498.1 3493914 3495245 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3493914..3495245) Escherichia coli SMS-3-5 6144233 YP_001745391.1 CDS tdcB NC_010498.1 3495267 3496256 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3495267..3496256) Escherichia coli SMS-3-5 6144404 YP_001745392.1 CDS tdcA NC_010498.1 3496355 3497293 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3496355..3497293) Escherichia coli SMS-3-5 6142904 YP_001745393.1 CDS tdcR NC_010498.1 3497482 3497826 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3497482..3497826 Escherichia coli SMS-3-5 6143580 YP_001745394.1 CDS EcSMS35_3416 NC_010498.1 3497908 3498045 R identified by Glimmer3; putative; hypothetical protein complement(3497908..3498045) Escherichia coli SMS-3-5 6144603 YP_001745395.1 CDS EcSMS35_3417 NC_010498.1 3498082 3498621 D identified by Glimmer3; putative; hypothetical protein 3498082..3498621 Escherichia coli SMS-3-5 6145288 YP_001745396.1 CDS EcSMS35_3418 NC_010498.1 3498643 3499830 D yhaC; identified by similarity to SP:P11864; hypothetical protein 3498643..3499830 Escherichia coli SMS-3-5 6143008 YP_001745397.1 CDS garK NC_010498.1 3500461 3501606 R identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase I complement(3500461..3501606) Escherichia coli SMS-3-5 6143943 YP_001745398.1 CDS garR NC_010498.1 3501703 3502587 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3501703..3502587) Escherichia coli SMS-3-5 6142877 YP_001745399.1 CDS garL NC_010498.1 3502623 3503393 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(3502623..3503393) Escherichia coli SMS-3-5 6147417 YP_001745400.1 CDS garP NC_010498.1 3503409 3504743 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00893; galactarate permease GarP complement(3503409..3504743) Escherichia coli SMS-3-5 6146497 YP_001745401.1 CDS EcSMS35_3423 NC_010498.1 3504764 3504889 D identified by Glimmer3; putative; hypothetical protein 3504764..3504889 Escherichia coli SMS-3-5 6147298 YP_001745402.1 CDS EcSMS35_3424 NC_010498.1 3504952 3505071 D identified by Glimmer3; putative; hypothetical protein 3504952..3505071 Escherichia coli SMS-3-5 6145160 YP_001745403.1 CDS garD NC_010498.1 3505118 3506689 D identified by match to protein family HMM PF04295; match to protein family HMM PF08666; match to protein family HMM TIGR03248; galactarate dehydratase 3505118..3506689 Escherichia coli SMS-3-5 6145644 YP_001745404.1 CDS sohA NC_010498.1 3507033 3507173 D HtrA suppressor protein SohA 3507033..3507173 Escherichia coli SMS-3-5 6145100 YP_001745405.1 CDS EcSMS35_3427 NC_010498.1 3507173 3507637 D hypothetical protein 3507173..3507637 Escherichia coli SMS-3-5 6145941 YP_001745406.1 CDS EcSMS35_3428 NC_010498.1 3507692 3508501 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(3507692..3508501) Escherichia coli SMS-3-5 6146365 YP_001745407.1 CDS EcSMS35_3429 NC_010498.1 3508750 3510030 D identified by match to protein family HMM PF08013; match to protein family HMM TIGR02810; D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit 3508750..3510030 Escherichia coli SMS-3-5 6144342 YP_001745408.1 CDS agaV NC_010498.1 3510053 3510526 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3510053..3510526 Escherichia coli SMS-3-5 6145021 YP_001745409.1 CDS agaW NC_010498.1 3510537 3511316 D identified by match to protein family HMM PF03609; PTS system, N-acetylgalactosamine-specific, IIC component 3510537..3511316 Escherichia coli SMS-3-5 6142876 YP_001745410.1 CDS agaE NC_010498.1 3511306 3512184 D identified by match to protein family HMM PF03613; PTS system N-acetylgalactosamine-specific, IID component 3511306..3512184 Escherichia coli SMS-3-5 6143544 YP_001745411.1 CDS agaF NC_010498.1 3512202 3512636 D identified by match to protein family HMM PF03610; PTS system, mannose/sorbose-specific, IIA component 3512202..3512636 Escherichia coli SMS-3-5 6142773 YP_001745412.1 CDS nagA1 NC_010498.1 3512612 3513766 D identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase 3512612..3513766 Escherichia coli SMS-3-5 6143374 YP_001745413.1 CDS EcSMS35_3435 NC_010498.1 3514117 3515271 D identified by match to protein family HMM PF01380; match to protein family HMM TIGR02815; AgaS family sugar isomerase 3514117..3515271 Escherichia coli SMS-3-5 6145313 YP_001745414.1 CDS kbaY NC_010498.1 3515284 3516144 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3515284..3516144 Escherichia coli SMS-3-5 6146840 YP_001745415.1 CDS agaB NC_010498.1 3516311 3516787 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3516311..3516787 Escherichia coli SMS-3-5 6146849 YP_001745416.1 CDS agaC NC_010498.1 3516826 3517629 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3516826..3517629 Escherichia coli SMS-3-5 6147501 YP_001745417.1 CDS agaD NC_010498.1 3517619 3518410 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3517619..3518410 Escherichia coli SMS-3-5 6146039 YP_001745418.1 CDS EcSMS35_3440 NC_010498.1 3518411 3519178 D identified by similarity to SP:P42912; match to protein family HMM PF01182; galactosamine-6-phosphate isomerase 3518411..3519178 Escherichia coli SMS-3-5 6146192 YP_001745419.1 CDS EcSMS35_3441 NC_010498.1 3519228 3520091 R yraL; identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; tetrapyrrole methylase family protein complement(3519228..3520091) Escherichia coli SMS-3-5 6145418 YP_001745420.1 CDS EcSMS35_3442 NC_010498.1 3520156 3522192 D identified by match to protein family HMM PF04348; putative lipoprotein 3520156..3522192 Escherichia coli SMS-3-5 6145975 YP_001745421.1 CDS EcSMS35_3443 NC_010498.1 3522150 3522545 D yraN; identified by match to protein family HMM PF02021; match to protein family HMM TIGR00252; hypothetical protein 3522150..3522545 Escherichia coli SMS-3-5 6144118 YP_001745422.1 CDS diaA NC_010498.1 3522565 3523155 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3522565..3523155 Escherichia coli SMS-3-5 6144634 YP_001745423.1 CDS EcSMS35_3445 NC_010498.1 3523165 3523740 D identified by match to protein family HMM PF04972; hypothetical protein 3523165..3523740 Escherichia coli SMS-3-5 6146324 YP_001745424.1 CDS EcSMS35_3446 NC_010498.1 3523853 3524893 R identified by match to protein family HMM PF03773; putative permease complement(3523853..3524893) Escherichia coli SMS-3-5 6144676 YP_001745425.1 CDS EcSMS35_3447 NC_010498.1 3524966 3525601 R identified by match to protein family HMM PF01370; NAD dependent epimerase/dehydratase family protein complement(3524966..3525601) Escherichia coli SMS-3-5 6142619 YP_001745426.1 CDS EcSMS35_3449 NC_010498.1 3525729 3526247 D identified by match to protein family HMM PF01965; match to protein family HMM TIGR01382; PfpI family intracellular peptidase 3525729..3526247 Escherichia coli SMS-3-5 6144380 YP_001745427.1 CDS EcSMS35_3448 NC_010498.1 3526227 3526670 R hypothetical protein complement(3526227..3526670) Escherichia coli SMS-3-5 6143152 YP_001745428.1 CDS EcSMS35_3451 NC_010498.1 3526721 3527023 D identified by match to protein family HMM PF01541; GIY-YIG nuclease superfamily protein 3526721..3527023 Escherichia coli SMS-3-5 6146519 YP_001745429.1 CDS EcSMS35_3450 NC_010498.1 3527010 3527513 R identified by match to protein family HMM PF00583; acetyltransferase complement(3527010..3527513) Escherichia coli SMS-3-5 6146131 YP_001745430.1 CDS EcSMS35_3452 NC_010498.1 3527507 3528031 R identified by match to protein family HMM PF02036; sterol-binding protein complement(3527507..3528031) Escherichia coli SMS-3-5 6146860 YP_001745431.1 CDS EcSMS35_3453 NC_010498.1 3528021 3528134 R identified by Glimmer3; putative; hypothetical protein complement(3528021..3528134) Escherichia coli SMS-3-5 6144262 YP_001745432.1 CDS EcSMS35_3454 NC_010498.1 3528240 3529235 D identified by match to protein family HMM PF01136; U32 family peptidase 3528240..3529235 Escherichia coli SMS-3-5 6145982 YP_001745433.1 CDS EcSMS35_3455 NC_010498.1 3529244 3530122 D identified by match to protein family HMM PF01136; U32 family peptidase 3529244..3530122 Escherichia coli SMS-3-5 6143206 YP_001745434.1 CDS EcSMS35_3456 NC_010498.1 3530203 3531210 D identified by match to protein family HMM PF00296; hypothetical protein 3530203..3531210 Escherichia coli SMS-3-5 6143348 YP_001745435.1 CDS mtr NC_010498.1 3531329 3532573 R tryptophan transporter of high affinity; tryptophan permease complement(3531329..3532573) Escherichia coli SMS-3-5 6143895 YP_001745436.1 CDS deaD NC_010498.1 3532727 3534616 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3532727..3534616) Escherichia coli SMS-3-5 6143001 YP_001745437.1 CDS nlpI NC_010498.1 3534796 3535680 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3534796..3535680) Escherichia coli SMS-3-5 6143616 YP_001745438.1 CDS pnp NC_010498.1 3535789 3537924 R identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase complement(3535789..3537924) Escherichia coli SMS-3-5 6146841 YP_001745439.1 CDS rpsO NC_010498.1 3538171 3538440 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3538171..3538440) Escherichia coli SMS-3-5 6146464 YP_001745440.1 CDS truB NC_010498.1 3538589 3539533 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3538589..3539533) Escherichia coli SMS-3-5 6146044 YP_001745441.1 CDS rbfA NC_010498.1 3539533 3539934 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3539533..3539934) Escherichia coli SMS-3-5 6145095 YP_001745442.1 CDS infB NC_010498.1 3540098 3542770 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3540098..3542770) Escherichia coli SMS-3-5 6144717 YP_001745443.1 CDS nusA NC_010498.1 3542795 3544282 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3542795..3544282) Escherichia coli SMS-3-5 6143036 YP_001745444.1 CDS EcSMS35_3466 NC_010498.1 3544310 3544774 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3544310..3544774) Escherichia coli SMS-3-5 6144741 YP_001745445.1 CDS argG NC_010498.1 3545393 3546736 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3545393..3546736 Escherichia coli SMS-3-5 6143631 YP_001745446.1 CDS yhbX NC_010498.1 3546744 3548261 R identified by match to protein family HMM PF00884; inner membrane protein yhbX complement(3546744..3548261) Escherichia coli SMS-3-5 6145555 YP_001745447.1 CDS secG NC_010498.1 3548929 3549261 R identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG complement(3548929..3549261) Escherichia coli SMS-3-5 6143620 YP_001745448.1 CDS glmM NC_010498.1 3549489 3550826 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3549489..3550826) Escherichia coli SMS-3-5 6144598 YP_001745449.1 CDS folP NC_010498.1 3550819 3551667 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(3550819..3551667) Escherichia coli SMS-3-5 6143462 YP_001745450.1 CDS hflB NC_010498.1 3551757 3553700 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3551757..3553700) Escherichia coli SMS-3-5 6146516 YP_001745451.1 CDS rrmJ NC_010498.1 3553791 3554420 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J complement(3553791..3554420) Escherichia coli SMS-3-5 6146737 YP_001745452.1 CDS EcSMS35_3476 NC_010498.1 3554546 3554839 D RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3554546..3554839 Escherichia coli SMS-3-5 6145507 YP_001745453.1 CDS greA NC_010498.1 3554995 3555471 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(3554995..3555471) Escherichia coli SMS-3-5 6145697 YP_001745454.1 CDS dacB NC_010498.1 3555720 3557153 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3555720..3557153 Escherichia coli SMS-3-5 6147529 YP_001745455.1 CDS obgE NC_010498.1 3557194 3558366 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3557194..3558366) Escherichia coli SMS-3-5 6145638 YP_001745456.1 CDS EcSMS35_3480 NC_010498.1 3558382 3559347 R identified by match to protein family HMM PF00892; putative transporter complement(3558382..3559347) Escherichia coli SMS-3-5 6147329 YP_001745457.1 CDS rpmA NC_010498.1 3559474 3559731 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3559474..3559731) Escherichia coli SMS-3-5 6146627 YP_001745458.1 CDS rplU NC_010498.1 3559752 3560063 R identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 complement(3559752..3560063) Escherichia coli SMS-3-5 6143423 YP_001745459.1 CDS ispB NC_010498.1 3560322 3561293 D identified by match to protein family HMM PF00348; octaprenyl diphosphate synthase 3560322..3561293 Escherichia coli SMS-3-5 6143339 YP_001745460.1 CDS sfsB NC_010498.1 3561522 3561800 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3561522..3561800 Escherichia coli SMS-3-5 6142722 YP_001745461.1 CDS murA NC_010498.1 3561848 3563107 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3561848..3563107) Escherichia coli SMS-3-5 6144571 YP_001745462.1 CDS EcSMS35_3486 NC_010498.1 3563162 3563431 R identified by match to protein family HMM PF01722; BolA/YrbA family protein complement(3563162..3563431) Escherichia coli SMS-3-5 6143867 YP_001745463.1 CDS yrbB NC_010498.1 3563576 3563869 R YrbB complement(3563576..3563869) Escherichia coli SMS-3-5 6147281 YP_001745464.1 CDS ttg2D NC_010498.1 3563869 3564504 R identified by match to protein family HMM PF05494; toluene tolerance protein Ttg2D complement(3563869..3564504) Escherichia coli SMS-3-5 6143307 YP_001745465.1 CDS EcSMS35_3489 NC_010498.1 3564523 3565074 R identified by match to protein family HMM PF02470; Mce family protein complement(3564523..3565074) Escherichia coli SMS-3-5 6146736 YP_001745466.1 CDS EcSMS35_3490 NC_010498.1 3565079 3565861 R identified by match to protein family HMM PF02405; match to protein family HMM TIGR00056; toluene ABC transporter permease complement(3565079..3565861) Escherichia coli SMS-3-5 6146706 YP_001745467.1 CDS EcSMS35_3491 NC_010498.1 3565869 3566678 R ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF complement(3565869..3566678) Escherichia coli SMS-3-5 6143509 YP_001745468.1 CDS EcSMS35_3492 NC_010498.1 3566888 3567865 D YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3566888..3567865 Escherichia coli SMS-3-5 6142820 YP_001745469.1 CDS kdsD NC_010498.1 3567879 3568865 D identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393; D-arabinose 5-phosphate isomerase 3567879..3568865 Escherichia coli SMS-3-5 6144035 YP_001745470.1 CDS kdsC NC_010498.1 3568886 3569452 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3568886..3569452 Escherichia coli SMS-3-5 6144019 YP_001745471.1 CDS EcSMS35_3495 NC_010498.1 3569449 3570024 D identified by match to protein family HMM PF06835; hypothetical protein 3569449..3570024 Escherichia coli SMS-3-5 6145694 YP_001745472.1 CDS lptA NC_010498.1 3569993 3570550 D LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3569993..3570550 Escherichia coli SMS-3-5 6145058 YP_001745473.1 CDS lptB NC_010498.1 3570557 3571282 D identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein YhbG 3570557..3571282 Escherichia coli SMS-3-5 6146701 YP_001745474.1 CDS rpoN NC_010498.1 3571330 3572763 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3571330..3572763 Escherichia coli SMS-3-5 6144563 YP_001745475.1 CDS yfiA NC_010498.1 3572786 3573073 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3572786..3573073 Escherichia coli SMS-3-5 6143330 YP_001745476.1 CDS ptsN NC_010498.1 3573191 3573682 D identified by match to protein family HMM PF00359; match to protein family HMM TIGR01419; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3573191..3573682 Escherichia coli SMS-3-5 6147519 YP_001745477.1 CDS EcSMS35_3501 NC_010498.1 3573728 3574582 D identified by match to protein family HMM PF03668; hypothetical protein 3573728..3574582 Escherichia coli SMS-3-5 6144748 YP_001745478.1 CDS ptsO NC_010498.1 3574579 3574851 D identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3574579..3574851 Escherichia coli SMS-3-5 6144058 YP_001745479.1 CDS EcSMS35_3504 NC_010498.1 3575065 3575697 D hypothetical protein 3575065..3575697 Escherichia coli SMS-3-5 6144982 YP_001745480.1 CDS mtgA NC_010498.1 3575694 3576422 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(3575694..3576422) Escherichia coli SMS-3-5 6146267 YP_001745481.1 CDS elbB NC_010498.1 3576419 3577072 R identified by match to protein family HMM PF01965; isoprenoid biosynthesis protein with amidotransferase-like domain complement(3576419..3577072) Escherichia coli SMS-3-5 6145491 YP_001745482.1 CDS arcB NC_010498.1 3577302 3579638 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3577302..3579638) Escherichia coli SMS-3-5 6143115 YP_001745483.1 CDS EcSMS35_3507 NC_010498.1 3579734 3580663 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR01212; radical SAM family protein complement(3579734..3580663) Escherichia coli SMS-3-5 6142725 YP_001745484.1 CDS gltB NC_010498.1 3581244 3585797 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3581244..3585797 Escherichia coli SMS-3-5 6147340 YP_001745485.1 CDS gltD NC_010498.1 3585810 3587228 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3585810..3587228 Escherichia coli SMS-3-5 6146884 YP_001745486.1 CDS EcSMS35_3510 NC_010498.1 3587461 3588783 D identified by match to protein family HMM PF04434; SWIM zinc finger domain-containing protein 3587461..3588783 Escherichia coli SMS-3-5 6146538 YP_001745487.1 CDS EcSMS35_3511 NC_010498.1 3588780 3590384 D hypothetical protein 3588780..3590384 Escherichia coli SMS-3-5 6143105 YP_001745488.1 CDS EcSMS35_3512 NC_010498.1 3590381 3591475 D identified by match to protein family HMM PF07728; AAA family ATPase 3590381..3591475 Escherichia coli SMS-3-5 6147398 YP_001745489.1 CDS EcSMS35_3513 NC_010498.1 3591493 3593742 D hypothetical protein 3591493..3593742 Escherichia coli SMS-3-5 6144783 YP_001745490.1 CDS EcSMS35_3514 NC_010498.1 3593732 3594901 D identified by match to protein family HMM PF05762; VWA domain-containing protein 3593732..3594901 Escherichia coli SMS-3-5 6145618 YP_001745491.1 CDS EcSMS35_3515 NC_010498.1 3595123 3595269 R identified by Glimmer3; putative; hypothetical protein complement(3595123..3595269) Escherichia coli SMS-3-5 6145964 YP_001745492.1 CDS EcSMS35_3516 NC_010498.1 3595939 3596403 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(3595939..3596403) Escherichia coli SMS-3-5 6145266 YP_001745493.1 CDS EcSMS35_3517 NC_010498.1 3596400 3597275 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3596400..3597275) Escherichia coli SMS-3-5 6146376 YP_001745494.1 CDS EcSMS35_3518 NC_010498.1 3597272 3597961 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3597272..3597961) Escherichia coli SMS-3-5 6147292 YP_001745495.1 CDS nanT1 NC_010498.1 3598009 3599499 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00891; putative sialic acid transporter complement(3598009..3599499) Escherichia coli SMS-3-5 6143258 YP_001745496.1 CDS nanA NC_010498.1 3599608 3600501 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3599608..3600501) Escherichia coli SMS-3-5 6142606 YP_001745497.1 CDS nanR NC_010498.1 3600623 3601405 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3600623..3601405) Escherichia coli SMS-3-5 6144733 YP_001745498.1 CDS EcSMS35_3522 NC_010498.1 3601794 3603161 D YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; putative cryptic C4-dicarboxylate transporter DcuD 3601794..3603161 Escherichia coli SMS-3-5 6144037 YP_001745499.1 CDS sspB NC_010498.1 3603205 3603702 R identified by match to protein family HMM PF04386; ClpXP protease specificity-enhancing factor complement(3603205..3603702) Escherichia coli SMS-3-5 6146068 YP_001745500.1 CDS sspA NC_010498.1 3603708 3604346 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3603708..3604346) Escherichia coli SMS-3-5 6145590 YP_001745501.1 CDS EcSMS35_3526 NC_010498.1 3604600 3604743 D identified by Glimmer3; putative; hypothetical protein 3604600..3604743 Escherichia coli SMS-3-5 6144931 YP_001745502.1 CDS rpsI NC_010498.1 3604740 3605132 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3604740..3605132) Escherichia coli SMS-3-5 6146568 YP_001745503.1 CDS rplM NC_010498.1 3605148 3605576 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3605148..3605576) Escherichia coli SMS-3-5 6147001 YP_001745504.1 CDS EcSMS35_3528 NC_010498.1 3605795 3606922 R identified by match to protein family HMM PF03969; AFG1 family ATPase complement(3605795..3606922) Escherichia coli SMS-3-5 6145973 YP_001745505.1 CDS EcSMS35_3529 NC_010498.1 3607116 3607514 D identified by match to protein family HMM PF06295; cytochrome d ubiquinol oxidase subunit III 3607116..3607514 Escherichia coli SMS-3-5 6143247 YP_001745506.1 CDS degQ NC_010498.1 3607668 3609035 D identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; serine endoprotease 3607668..3609035 Escherichia coli SMS-3-5 6142665 YP_001745507.1 CDS degS NC_010498.1 3609125 3610192 D identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02038; serine endoprotease 3609125..3610192 Escherichia coli SMS-3-5 6146247 YP_001745508.1 CDS mdh NC_010498.1 3610255 3611193 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3610255..3611193) Escherichia coli SMS-3-5 6143215 YP_001745509.1 CDS argR NC_010498.1 3611628 3612098 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3611628..3612098 Escherichia coli SMS-3-5 6145462 YP_001745510.1 CDS ycfR NC_010498.1 3612463 3612726 D identified by match to protein family HMM PF07338; protein YcfR 3612463..3612726 Escherichia coli SMS-3-5 6146747 YP_001745511.1 CDS EcSMS35_3535 NC_010498.1 3612782 3613054 R hypothetical protein complement(3612782..3613054) Escherichia coli SMS-3-5 6142703 YP_001745512.1 CDS aaeB NC_010498.1 3613146 3615113 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3613146..3615113) Escherichia coli SMS-3-5 6144594 YP_001745513.1 CDS aaeA NC_010498.1 3615119 3616051 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(3615119..3616051) Escherichia coli SMS-3-5 6146535 YP_001745514.1 CDS aaeX NC_010498.1 3616059 3616331 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3616059..3616331) Escherichia coli SMS-3-5 6147243 YP_001745515.1 CDS aaeR NC_010498.1 3616445 3617374 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator 3616445..3617374 Escherichia coli SMS-3-5 6142733 YP_001745516.1 CDS tldD NC_010498.1 3617502 3618947 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(3617502..3618947) Escherichia coli SMS-3-5 6143370 YP_001745517.1 CDS EcSMS35_3541 NC_010498.1 3619103 3622903 R yhdP; identified by match to protein family HMM TIGR02099; hypothetical protein complement(3619103..3622903) Escherichia coli SMS-3-5 6144610 YP_001745518.1 CDS cafA NC_010498.1 3622971 3624440 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3622971..3624440) Escherichia coli SMS-3-5 6147375 YP_001745519.1 CDS maf1 NC_010498.1 3624430 3625023 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3624430..3625023) Escherichia coli SMS-3-5 6144127 YP_001745520.1 CDS lytS NC_010498.1 3625032 3625520 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3625032..3625520) Escherichia coli SMS-3-5 6143843 YP_001745521.1 CDS mreC NC_010498.1 3625520 3626623 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3625520..3626623) Escherichia coli SMS-3-5 6147497 YP_001745522.1 CDS mreB NC_010498.1 3626689 3627732 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3626689..3627732) Escherichia coli SMS-3-5 6144405 YP_001745523.1 CDS EcSMS35_3547 NC_010498.1 3628037 3629977 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3628037..3629977) Escherichia coli SMS-3-5 6143611 YP_001745524.1 CDS EcSMS35_3548 NC_010498.1 3630129 3631103 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02823; quinone oxidoreductase 3630129..3631103 Escherichia coli SMS-3-5 6144030 YP_001745525.1 CDS EcSMS35_3549 NC_010498.1 3631140 3631970 D hypothetical protein 3631140..3631970 Escherichia coli SMS-3-5 6147200 YP_001745526.1 CDS accB NC_010498.1 3632836 3633306 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3632836..3633306 Escherichia coli SMS-3-5 6145446 YP_001745527.1 CDS accC NC_010498.1 3633317 3634666 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3633317..3634666 Escherichia coli SMS-3-5 6144495 YP_001745528.1 CDS EcSMS35_3552 NC_010498.1 3634775 3635017 D identified by match to protein family HMM PF06196; hypothetical protein 3634775..3635017 Escherichia coli SMS-3-5 6142901 YP_001745529.1 CDS panF NC_010498.1 3635007 3636458 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3635007..3636458 Escherichia coli SMS-3-5 6145517 YP_001745530.1 CDS prmA NC_010498.1 3636470 3637351 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3636470..3637351 Escherichia coli SMS-3-5 6143760 YP_001745531.1 CDS dusB NC_010498.1 3637680 3638645 D identified by match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 3637680..3638645 Escherichia coli SMS-3-5 6146960 YP_001745532.1 CDS fis NC_010498.1 3638671 3638967 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3638671..3638967 Escherichia coli SMS-3-5 6145059 YP_001745533.1 CDS EcSMS35_3557 NC_010498.1 3639053 3639937 D identified by match to protein family HMM PF01555; putative methyltransferase 3639053..3639937 Escherichia coli SMS-3-5 6146515 YP_001745534.1 CDS EcSMS35_3558 NC_010498.1 3640087 3640200 D hypothetical protein 3640087..3640200 Escherichia coli SMS-3-5 6145026 YP_001745535.1 CDS EcSMS35_3559 NC_010498.1 3640203 3640865 R identified by match to protein family HMM PF00440; match to protein family HMM PF08361; DNA-binding transcriptional regulator EnvR complement(3640203..3640865) Escherichia coli SMS-3-5 6146661 YP_001745536.1 CDS acrE NC_010498.1 3641264 3642421 D identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; acriflavine resistance protein E 3641264..3642421 Escherichia coli SMS-3-5 6142985 YP_001745537.1 CDS EcSMS35_3562 NC_010498.1 3645783 3646004 D putative lipoprotein 3645783..3646004 Escherichia coli SMS-3-5 6144794 YP_001745538.1 CDS EcSMS35_3563 NC_010498.1 3646435 3647460 D amino acid ABC transporter periplasmic amino acid-binding protein 3646435..3647460 Escherichia coli SMS-3-5 6145678 YP_001745539.1 CDS EcSMS35_3564 NC_010498.1 3647528 3648709 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; His/Glu/Gln/Arg/opine ABC transporter permease 3647528..3648709 Escherichia coli SMS-3-5 6147128 YP_001745540.1 CDS EcSMS35_3565 NC_010498.1 3648719 3649822 D yhdY; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; His/Glu/Gln/Arg/opine ABC transporter permease 3648719..3649822 Escherichia coli SMS-3-5 6146434 YP_001745541.1 CDS EcSMS35_3566 NC_010498.1 3649830 3650588 D identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 3649830..3650588 Escherichia coli SMS-3-5 6143614 YP_001745542.1 CDS EcSMS35_3576 NC_010498.1 3656471 3657025 D hypothetical protein 3656471..3657025 Escherichia coli SMS-3-5 6143727 YP_001745543.1 CDS EcSMS35_3575 NC_010498.1 3657001 3657258 R identified by match to protein family HMM PF07369; hypothetical protein complement(3657001..3657258) Escherichia coli SMS-3-5 6146126 YP_001745544.1 CDS aroE NC_010498.1 3657255 3658073 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3657255..3658073) Escherichia coli SMS-3-5 6145952 YP_001745545.1 CDS EcSMS35_3578 NC_010498.1 3658078 3658650 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor complement(3658078..3658650) Escherichia coli SMS-3-5 6146738 YP_001745546.1 CDS EcSMS35_3579 NC_010498.1 3658655 3659197 R identified by match to protein family HMM PF01396; topoisomerase DNA-binding C4 zinc finger domain-containing protein complement(3658655..3659197) Escherichia coli SMS-3-5 6142640 YP_001745547.1 CDS smg NC_010498.1 3659226 3659699 R identified by match to protein family HMM PF04361; hypothetical protein complement(3659226..3659699) Escherichia coli SMS-3-5 6143156 YP_001745548.1 CDS dprA NC_010498.1 3659671 3660795 R identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA complement(3659671..3660795) Escherichia coli SMS-3-5 6144004 YP_001745549.1 CDS def NC_010498.1 3660925 3661434 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3660925..3661434 Escherichia coli SMS-3-5 6145836 YP_001745550.1 CDS fmt NC_010498.1 3661449 3662396 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3661449..3662396 Escherichia coli SMS-3-5 6145017 YP_001745551.1 CDS rsmB NC_010498.1 3662442 3663731 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3662442..3663731 Escherichia coli SMS-3-5 6146958 YP_001745552.1 CDS trkA NC_010498.1 3663753 3665129 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3663753..3665129 Escherichia coli SMS-3-5 6143400 YP_001745553.1 CDS mscL NC_010498.1 3665259 3665669 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3665259..3665669 Escherichia coli SMS-3-5 6144176 YP_001745554.1 CDS zntR NC_010498.1 3665940 3666365 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(3665940..3666365) Escherichia coli SMS-3-5 6144343 YP_001745555.1 CDS EcSMS35_3588 NC_010498.1 3666376 3666744 R hypothetical protein complement(3666376..3666744) Escherichia coli SMS-3-5 6145009 YP_001745556.1 CDS rplQ NC_010498.1 3666851 3667234 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3666851..3667234) Escherichia coli SMS-3-5 6146617 YP_001745557.1 CDS rpoA NC_010498.1 3667275 3668264 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3667275..3668264) Escherichia coli SMS-3-5 6147180 YP_001745558.1 CDS rpsD NC_010498.1 3668290 3668910 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3668290..3668910) Escherichia coli SMS-3-5 6142713 YP_001745559.1 CDS rpsK NC_010498.1 3668944 3669333 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3668944..3669333) Escherichia coli SMS-3-5 6142617 YP_001745560.1 CDS rpsM NC_010498.1 3669350 3669706 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3669350..3669706) Escherichia coli SMS-3-5 6143979 YP_001745561.1 CDS rpmJ NC_010498.1 3669853 3669969 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(3669853..3669969) Escherichia coli SMS-3-5 6147472 YP_001745562.1 CDS secY NC_010498.1 3670001 3671332 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(3670001..3671332) Escherichia coli SMS-3-5 6146762 YP_001745563.1 CDS rplO NC_010498.1 3671340 3671774 R late assembly protein; 50S ribosomal protein L15 complement(3671340..3671774) Escherichia coli SMS-3-5 6146145 YP_001745564.1 CDS rpmD NC_010498.1 3671778 3671957 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(3671778..3671957) Escherichia coli SMS-3-5 6147452 YP_001745565.1 CDS rpsE NC_010498.1 3671961 3672464 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(3671961..3672464) Escherichia coli SMS-3-5 6143211 YP_001745566.1 CDS rplR NC_010498.1 3672479 3672832 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(3672479..3672832) Escherichia coli SMS-3-5 6144009 YP_001745567.1 CDS rplF NC_010498.1 3672842 3673375 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(3672842..3673375) Escherichia coli SMS-3-5 6144688 YP_001745568.1 CDS rpsH NC_010498.1 3673388 3673780 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(3673388..3673780) Escherichia coli SMS-3-5 6144702 YP_001745569.1 CDS rpsN NC_010498.1 3673814 3674119 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(3673814..3674119) Escherichia coli SMS-3-5 6145431 YP_001745570.1 CDS rplE NC_010498.1 3674134 3674673 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(3674134..3674673) Escherichia coli SMS-3-5 6146087 YP_001745571.1 CDS rplX NC_010498.1 3674688 3675002 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(3674688..3675002) Escherichia coli SMS-3-5 6142926 YP_001745572.1 CDS rplN NC_010498.1 3675013 3675384 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(3675013..3675384) Escherichia coli SMS-3-5 6146563 YP_001745573.1 CDS rpsQ NC_010498.1 3675549 3675803 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(3675549..3675803) Escherichia coli SMS-3-5 6147113 YP_001745574.1 CDS rpmC NC_010498.1 3675803 3675994 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(3675803..3675994) Escherichia coli SMS-3-5 6145187 YP_001745575.1 CDS rplP NC_010498.1 3675994 3676404 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(3675994..3676404) Escherichia coli SMS-3-5 6145705 YP_001745576.1 CDS rpsC NC_010498.1 3676417 3677118 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(3676417..3677118) Escherichia coli SMS-3-5 6144350 YP_001745577.1 CDS rplV NC_010498.1 3677136 3677468 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(3677136..3677468) Escherichia coli SMS-3-5 6142663 YP_001745578.1 CDS rpsS NC_010498.1 3677483 3677761 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(3677483..3677761) Escherichia coli SMS-3-5 6142938 YP_001745579.1 CDS rplB NC_010498.1 3677778 3678599 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(3677778..3678599) Escherichia coli SMS-3-5 6146224 YP_001745580.1 CDS rplW NC_010498.1 3678617 3678919 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(3678617..3678919) Escherichia coli SMS-3-5 6147303 YP_001745581.1 CDS rplD NC_010498.1 3678916 3679521 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(3678916..3679521) Escherichia coli SMS-3-5 6145223 YP_001745582.1 CDS rplC NC_010498.1 3679532 3680161 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(3679532..3680161) Escherichia coli SMS-3-5 6143795 YP_001745583.1 CDS rpsJ NC_010498.1 3680194 3680505 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(3680194..3680505) Escherichia coli SMS-3-5 6144487 YP_001745584.1 CDS EcSMS35_3618 NC_010498.1 3680884 3681351 D identified by match to protein family HMM PF01478; A24 family peptidase 3680884..3681351 Escherichia coli SMS-3-5 6142917 YP_001745585.1 CDS bfr NC_010498.1 3681348 3681824 R iron storage protein; bacterioferritin complement(3681348..3681824) Escherichia coli SMS-3-5 6146450 YP_001745586.1 CDS bfd NC_010498.1 3681897 3682091 R identified by match to protein family HMM PF04324; bacterioferritin-associated ferredoxin complement(3681897..3682091) Escherichia coli SMS-3-5 6143602 YP_001745587.1 CDS tuf2 NC_010498.1 3682274 3683458 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(3682274..3683458) Escherichia coli SMS-3-5 6147134 YP_001745588.1 CDS fusA NC_010498.1 3683529 3685643 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(3683529..3685643) Escherichia coli SMS-3-5 6145495 YP_001745589.1 CDS rpsG NC_010498.1 3685740 3686210 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(3685740..3686210) Escherichia coli SMS-3-5 6145934 YP_001745590.1 CDS rpsL NC_010498.1 3686307 3686681 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(3686307..3686681) Escherichia coli SMS-3-5 6144228 YP_001745591.1 CDS dsrH NC_010498.1 3686807 3687094 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(3686807..3687094) Escherichia coli SMS-3-5 6147469 YP_001745592.1 CDS tusC NC_010498.1 3687102 3687461 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(3687102..3687461) Escherichia coli SMS-3-5 6146916 YP_001745593.1 CDS tusD NC_010498.1 3687461 3687847 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(3687461..3687847) Escherichia coli SMS-3-5 6146407 YP_001745594.1 CDS EcSMS35_3627 NC_010498.1 3687847 3688569 R identified by match to protein family HMM PF08348; hypothetical protein complement(3687847..3688569) Escherichia coli SMS-3-5 6145806 YP_001745595.1 CDS fkpA NC_010498.1 3688736 3689548 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3688736..3689548) Escherichia coli SMS-3-5 6145292 YP_001745596.1 CDS EcSMS35_3629 NC_010498.1 3689769 3689987 D identified by match to protein family HMM PF04102; hypothetical protein 3689769..3689987 Escherichia coli SMS-3-5 6144871 YP_001745597.1 CDS slyD NC_010498.1 3690037 3690627 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3690037..3690627) Escherichia coli SMS-3-5 6143103 YP_001745598.1 CDS EcSMS35_3631 NC_010498.1 3690722 3690922 R identified by match to protein family HMM TIGR02443; hypothetical protein complement(3690722..3690922) Escherichia coli SMS-3-5 6147473 YP_001745599.1 CDS kefB NC_010498.1 3690932 3692737 R involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB complement(3690932..3692737) Escherichia coli SMS-3-5 6146785 YP_001745600.1 CDS kefG NC_010498.1 3692737 3693288 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(3692737..3693288) Escherichia coli SMS-3-5 6146412 YP_001745601.1 CDS EcSMS35_3634 NC_010498.1 3693419 3695332 D identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein 3693419..3695332 Escherichia coli SMS-3-5 6143313 YP_001745602.1 CDS EcSMS35_3635 NC_010498.1 3695332 3696354 D identified by match to protein family HMM PF00561; putative hydrolase 3695332..3696354 Escherichia coli SMS-3-5 6143985 YP_001745603.1 CDS EcSMS35_3636 NC_010498.1 3696348 3696566 D identified by match to protein family HMM PF06794; hypothetical protein 3696348..3696566 Escherichia coli SMS-3-5 6147253 YP_001745604.1 CDS EcSMS35_3637 NC_010498.1 3696620 3697489 D identified by match to protein family HMM PF00485; phosphoribulokinase/uridine kinase family protein 3696620..3697489 Escherichia coli SMS-3-5 6142719 YP_001745605.1 CDS EcSMS35_3638 NC_010498.1 3697544 3697948 R identified by match to protein family HMM PF02566; hypothetical protein complement(3697544..3697948) Escherichia coli SMS-3-5 6147248 YP_001745606.1 CDS crp NC_010498.1 3698250 3698882 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3698250..3698882 Escherichia coli SMS-3-5 6146750 YP_001745607.1 CDS EcSMS35_3640 NC_010498.1 3698933 3701023 D identified by match to protein family HMM PF05976; match to protein family HMM TIGR01667; YccS/YhfK family integral membrane protein 3698933..3701023 Escherichia coli SMS-3-5 6145814 YP_001745608.1 CDS argD NC_010498.1 3701086 3702309 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein complement(3701086..3702309) Escherichia coli SMS-3-5 6146675 YP_001745609.1 CDS pabA NC_010498.1 3702395 3702958 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(3702395..3702958) Escherichia coli SMS-3-5 6143954 YP_001745610.1 CDS fic NC_010498.1 3702990 3703592 R identified by match to protein family HMM PF02661; cell filamentation protein Fic complement(3702990..3703592) Escherichia coli SMS-3-5 6144727 YP_001745611.1 CDS ppiA NC_010498.1 3703854 3704426 R identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase A (rotamase A) complement(3703854..3704426) Escherichia coli SMS-3-5 6146194 YP_001745612.1 CDS EcSMS35_3645 NC_010498.1 3704570 3704716 R identified by Glimmer3; putative; hypothetical protein complement(3704570..3704716) Escherichia coli SMS-3-5 6146058 YP_001745613.1 CDS tsgA NC_010498.1 3704697 3705878 D identified by match to protein family HMM PF07690; hypothetical protein 3704697..3705878 Escherichia coli SMS-3-5 6146691 YP_001745614.1 CDS nirB NC_010498.1 3706140 3708683 D identified by match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; match to protein family HMM PF07992; match to protein family HMM TIGR02374; nitrite reductase [NAD(P)H], large subunit 3706140..3708683 Escherichia coli SMS-3-5 6146964 YP_001745615.1 CDS nirD NC_010498.1 3708680 3709006 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3708680..3709006 Escherichia coli SMS-3-5 6147475 YP_001745616.1 CDS nirC NC_010498.1 3709131 3709937 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3709131..3709937 Escherichia coli SMS-3-5 6143398 YP_001745617.1 CDS cysG NC_010498.1 3709956 3711329 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3709956..3711329 Escherichia coli SMS-3-5 6143292 YP_001745618.1 CDS EcSMS35_3651 NC_010498.1 3711580 3711747 D putative lipoprotein 3711580..3711747 Escherichia coli SMS-3-5 6144867 YP_001745619.1 CDS EcSMS35_3652 NC_010498.1 3711854 3712939 R identified by similarity to GB:ABF05423.1; hypothetical protein complement(3711854..3712939) Escherichia coli SMS-3-5 6145214 YP_001745620.1 CDS EcSMS35_3653 NC_010498.1 3712951 3714255 R hypothetical protein complement(3712951..3714255) Escherichia coli SMS-3-5 6146260 YP_001745621.1 CDS EcSMS35_3654 NC_010498.1 3714267 3714620 R hypothetical protein complement(3714267..3714620) Escherichia coli SMS-3-5 6144302 YP_001745622.1 CDS EcSMS35_3655 NC_010498.1 3714631 3715509 R phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase complement(3714631..3715509) Escherichia coli SMS-3-5 6145283 YP_001745623.1 CDS EcSMS35_3656 NC_010498.1 3715506 3716732 R identified by match to protein family HMM PF01676; match to protein family HMM PF08342; putative mutase complement(3715506..3716732) Escherichia coli SMS-3-5 6144623 YP_001745624.1 CDS EcSMS35_3657 NC_010498.1 3716732 3717895 R identified by match to protein family HMM PF01168; alanine racemase complement(3716732..3717895) Escherichia coli SMS-3-5 6144271 YP_001745625.1 CDS EcSMS35_3658 NC_010498.1 3717979 3718341 R hypothetical protein complement(3717979..3718341) Escherichia coli SMS-3-5 6143473 YP_001745626.1 CDS EcSMS35_3659 NC_010498.1 3718358 3719263 R hypothetical protein complement(3718358..3719263) Escherichia coli SMS-3-5 6144194 YP_001745627.1 CDS trpS NC_010498.1 3719423 3720427 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(3719423..3720427) Escherichia coli SMS-3-5 6144938 YP_001745628.1 CDS gph NC_010498.1 3720420 3721178 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(3720420..3721178) Escherichia coli SMS-3-5 6145268 YP_001745629.1 CDS rpe NC_010498.1 3721171 3721848 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(3721171..3721848) Escherichia coli SMS-3-5 6145981 YP_001745630.1 CDS dam NC_010498.1 3721866 3722702 R identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; DNA adenine methylase complement(3721866..3722702) Escherichia coli SMS-3-5 6144553 YP_001745631.1 CDS damX NC_010498.1 3722809 3724095 R identified by match to protein family HMM PF05036; hypothetical protein complement(3722809..3724095) Escherichia coli SMS-3-5 6143251 YP_001745632.1 CDS aroB NC_010498.1 3724187 3725275 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(3724187..3725275) Escherichia coli SMS-3-5 6147370 YP_001745633.1 CDS aroK NC_010498.1 3725332 3726009 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(3725332..3726009) Escherichia coli SMS-3-5 6144818 YP_001745634.1 CDS hofQ NC_010498.1 3726254 3727492 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ complement(3726254..3727492) Escherichia coli SMS-3-5 6144186 YP_001745635.1 CDS EcSMS35_3668 NC_010498.1 3727404 3727808 R hypothetical protein complement(3727404..3727808) Escherichia coli SMS-3-5 6145843 YP_001745636.1 CDS EcSMS35_3669 NC_010498.1 3727798 3727995 R hypothetical protein complement(3727798..3727995) Escherichia coli SMS-3-5 6145335 YP_001745637.1 CDS EcSMS35_3670 NC_010498.1 3727981 3728100 D identified by Glimmer3; putative; hypothetical protein 3727981..3728100 Escherichia coli SMS-3-5 6146326 YP_001745638.1 CDS EcSMS35_3671 NC_010498.1 3728222 3728761 R identified by match to protein family HMM PF05137; PilN family protein complement(3728222..3728761) Escherichia coli SMS-3-5 6143061 YP_001745639.1 CDS hofM NC_010498.1 3728761 3729540 R HofM protein complement(3728761..3729540) Escherichia coli SMS-3-5 6147446 YP_001745640.1 CDS mrcA NC_010498.1 3729636 3732212 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3729636..3732212 Escherichia coli SMS-3-5 6144784 YP_001745641.1 CDS nudE NC_010498.1 3732380 3732940 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(3732380..3732940) Escherichia coli SMS-3-5 6142731 YP_001745642.1 CDS EcSMS35_3675 NC_010498.1 3733144 3733263 D identified by Glimmer3; putative; hypothetical protein 3733144..3733263 Escherichia coli SMS-3-5 6144696 YP_001745643.1 CDS EcSMS35_3676 NC_010498.1 3733260 3735395 D identified by match to protein family HMM PF07095; hypothetical protein 3733260..3735395 Escherichia coli SMS-3-5 6144225 YP_001745644.1 CDS EcSMS35_3677 NC_010498.1 3735460 3736128 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; HAD family hydrolase 3735460..3736128 Escherichia coli SMS-3-5 6146079 YP_001745645.1 CDS hslR NC_010498.1 3736139 3736540 D identified by match to protein family HMM PF01479; ribosome-associated heat shock protein Hsp15 3736139..3736540 Escherichia coli SMS-3-5 6145531 YP_001745646.1 CDS hslO NC_010498.1 3736565 3737443 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3736565..3737443 Escherichia coli SMS-3-5 6145028 YP_001745647.1 CDS EcSMS35_3680 NC_010498.1 3737577 3739301 R hypothetical protein complement(3737577..3739301) Escherichia coli SMS-3-5 6146954 YP_001745648.1 CDS EcSMS35_3681 NC_010498.1 3739307 3739435 R identified by Glimmer3; putative; hypothetical protein complement(3739307..3739435) Escherichia coli SMS-3-5 6146429 YP_001745649.1 CDS pckA NC_010498.1 3739680 3741302 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3739680..3741302 Escherichia coli SMS-3-5 6143365 YP_001745650.1 CDS EcSMS35_3683 NC_010498.1 3741417 3741734 D identified by similarity to GB:ABA72014.1; hypothetical protein 3741417..3741734 Escherichia coli SMS-3-5 6142838 YP_001745651.1 CDS EcSMS35_3684 NC_010498.1 3741793 3742089 D yiaG; identified by similarity to GB:CAE16739.1; hypothetical protein 3741793..3742089 Escherichia coli SMS-3-5 6146658 YP_001745652.1 CDS envZ NC_010498.1 3742121 3743473 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(3742121..3743473) Escherichia coli SMS-3-5 6145130 YP_001745653.1 CDS ompR NC_010498.1 3743470 3744189 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(3743470..3744189) Escherichia coli SMS-3-5 6145369 YP_001745654.1 CDS greB NC_010498.1 3744417 3744893 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3744417..3744893 Escherichia coli SMS-3-5 6143738 YP_001745655.1 CDS EcSMS35_3688 NC_010498.1 3744990 3747311 D yhgF; identified by similarity to SP:P46837; match to protein family HMM PF00575; putative transcriptional accessory protein 3744990..3747311 Escherichia coli SMS-3-5 6144574 YP_001745656.1 CDS feoA NC_010498.1 3747749 3747976 D identified by similarity to SP:P0AEL3; match to protein family HMM PF04023; ferrous iron transport protein A 3747749..3747976 Escherichia coli SMS-3-5 6142886 YP_001745657.1 CDS feoB NC_010498.1 3747993 3750314 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3747993..3750314 Escherichia coli SMS-3-5 6143091 YP_001745658.1 CDS EcSMS35_3691 NC_010498.1 3750314 3750550 D identified by match to protein family HMM PF09012; hypothetical protein 3750314..3750550 Escherichia coli SMS-3-5 6146564 YP_001745659.1 CDS EcSMS35_3692 NC_010498.1 3750753 3751631 D identified by similarity to GB:AAP19288.1; match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 3750753..3751631 Escherichia coli SMS-3-5 6147269 YP_001745660.1 CDS EcSMS35_3693 NC_010498.1 3751660 3752430 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(3751660..3752430) Escherichia coli SMS-3-5 6142844 YP_001745661.1 CDS gntX NC_010498.1 3752468 3753151 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3752468..3753151 Escherichia coli SMS-3-5 6144683 YP_001745662.1 CDS gntY NC_010498.1 3753210 3753785 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 3753210..3753785 Escherichia coli SMS-3-5 6146012 YP_001745663.1 CDS gntT NC_010498.1 3754146 3755462 D identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; high-affinity gluconate transporter 3754146..3755462 Escherichia coli SMS-3-5 6145388 YP_001745664.1 CDS malQ NC_010498.1 3755507 3757591 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(3755507..3757591) Escherichia coli SMS-3-5 6145205 YP_001745665.1 CDS malP NC_010498.1 3757601 3759994 R identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; maltodextrin phosphorylase complement(3757601..3759994) Escherichia coli SMS-3-5 6146740 YP_001745666.1 CDS malT NC_010498.1 3760617 3763322 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3760617..3763322 Escherichia coli SMS-3-5 6143219 YP_001745667.1 CDS rtcA NC_010498.1 3763365 3764381 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(3763365..3764381) Escherichia coli SMS-3-5 6147489 YP_001745668.1 CDS rtcB NC_010498.1 3764385 3765611 R identified by match to protein family HMM PF01139; RtcB protein complement(3764385..3765611) Escherichia coli SMS-3-5 6144881 YP_001745669.1 CDS rtcR NC_010498.1 3765799 3767397 D identified by match to protein family HMM PF00158; match to protein family HMM PF06956; match to protein family HMM PF07728; sigma-54 dependent transcriptional regulator RtcR 3765799..3767397 Escherichia coli SMS-3-5 6144039 YP_001745670.1 CDS glpR NC_010498.1 3767379 3768137 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(3767379..3768137) Escherichia coli SMS-3-5 6144447 YP_001745671.1 CDS EcSMS35_3704 NC_010498.1 3768154 3768984 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(3768154..3768984) Escherichia coli SMS-3-5 6143117 YP_001745672.1 CDS glpE NC_010498.1 3769029 3769355 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(3769029..3769355) Escherichia coli SMS-3-5 6142990 YP_001745673.1 CDS glpD NC_010498.1 3769545 3771050 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3769545..3771050 Escherichia coli SMS-3-5 6143533 YP_001745674.1 CDS EcSMS35_3708 NC_010498.1 3771868 3772860 R hypothetical protein complement(3771868..3772860) Escherichia coli SMS-3-5 6147059 YP_001745675.1 CDS EcSMS35_3709 NC_010498.1 3772886 3774391 R hypothetical protein complement(3772886..3774391) Escherichia coli SMS-3-5 6142839 YP_001745676.1 CDS glgP NC_010498.1 3774520 3776967 R identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase complement(3774520..3776967) Escherichia coli SMS-3-5 6145870 YP_001745677.1 CDS glgA NC_010498.1 3776986 3778419 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(3776986..3778419) Escherichia coli SMS-3-5 6146342 YP_001745678.1 CDS glgC NC_010498.1 3778419 3779714 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(3778419..3779714) Escherichia coli SMS-3-5 6145179 YP_001745679.1 CDS glgX NC_010498.1 3779732 3781705 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme complement(3779732..3781705) Escherichia coli SMS-3-5 6146321 YP_001745680.1 CDS glgB NC_010498.1 3781702 3783888 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme complement(3781702..3783888) Escherichia coli SMS-3-5 6143963 YP_001745681.1 CDS asd NC_010498.1 3784161 3785264 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(3784161..3785264) Escherichia coli SMS-3-5 6144622 YP_001745682.1 CDS EcSMS35_3716 NC_010498.1 3785456 3786049 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 3785456..3786049 Escherichia coli SMS-3-5 6144535 YP_001745683.1 CDS EcSMS35_3717 NC_010498.1 3786095 3787297 R identified by match to protein family HMM PF02481; putative DNA protecting protein DprA complement(3786095..3787297) Escherichia coli SMS-3-5 6143927 YP_001745684.1 CDS EcSMS35_3718 NC_010498.1 3787297 3789393 R identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614; ATP-dependent DNA helicase RecQ complement(3787297..3789393) Escherichia coli SMS-3-5 6142785 YP_001745685.1 CDS gntU NC_010498.1 3789533 3790873 R identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; low affinity gluconate transporter complement(3789533..3790873) Escherichia coli SMS-3-5 6143476 YP_001745686.1 CDS gntK NC_010498.1 3790877 3791425 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 complement(3790877..3791425) Escherichia coli SMS-3-5 6144294 YP_001745687.1 CDS gntR NC_010498.1 3791543 3792538 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator GntR complement(3791543..3792538) Escherichia coli SMS-3-5 6144406 YP_001745688.1 CDS EcSMS35_3723 NC_010498.1 3792616 3792765 D identified by Glimmer3; putative; hypothetical protein 3792616..3792765 Escherichia coli SMS-3-5 6145578 YP_001745689.1 CDS EcSMS35_3722 NC_010498.1 3792762 3793457 R identified by match to protein family HMM PF02678; match to protein family HMM PF07883; pirin family protein complement(3792762..3793457) Escherichia coli SMS-3-5 6145509 YP_001745690.1 CDS EcSMS35_3724 NC_010498.1 3793580 3794617 R identified by match to protein family HMM PF01408; match to protein family HMM PF02894; putative dehydrogenase complement(3793580..3794617) Escherichia coli SMS-3-5 6144657 YP_001745691.1 CDS EcSMS35_3725 NC_010498.1 3794951 3795439 D YhhY; regulated by the fur regulator; unknown function; putative acetyltransferase YhhY 3794951..3795439 Escherichia coli SMS-3-5 6145588 YP_001745692.1 CDS ggt NC_010498.1 3795500 3797245 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(3795500..3797245) Escherichia coli SMS-3-5 6144138 YP_001745693.1 CDS EcSMS35_3728 NC_010498.1 3797365 3797805 D hypothetical protein 3797365..3797805 Escherichia coli SMS-3-5 6144671 YP_001745694.1 CDS ugpQ NC_010498.1 3797792 3798535 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase complement(3797792..3798535) Escherichia coli SMS-3-5 6143124 YP_001745695.1 CDS ugpC NC_010498.1 3798532 3799602 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit complement(3798532..3799602) Escherichia coli SMS-3-5 6147384 YP_001745696.1 CDS EcSMS35_3730 NC_010498.1 3799604 3800449 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(3799604..3800449) Escherichia coli SMS-3-5 6147144 YP_001745697.1 CDS ugpA NC_010498.1 3800446 3801333 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(3800446..3801333) Escherichia coli SMS-3-5 6146873 YP_001745698.1 CDS ugpB NC_010498.1 3801431 3802747 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(3801431..3802747) Escherichia coli SMS-3-5 6146056 YP_001745699.1 CDS EcSMS35_3733 NC_010498.1 3802958 3803110 R identified by Glimmer3; putative; hypothetical protein complement(3802958..3803110) Escherichia coli SMS-3-5 6145145 YP_001745700.1 CDS EcSMS35_3734 NC_010498.1 3803107 3803853 R hypothetical protein complement(3803107..3803853) Escherichia coli SMS-3-5 6146492 YP_001745701.1 CDS EcSMS35_3736 NC_010498.1 3803852 3803983 D identified by Glimmer3; putative; hypothetical protein 3803852..3803983 Escherichia coli SMS-3-5 6143456 YP_001745702.1 CDS livF NC_010498.1 3803972 3804685 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3803972..3804685) Escherichia coli SMS-3-5 6144344 YP_001745703.1 CDS livG NC_010498.1 3804687 3805454 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3804687..3805454) Escherichia coli SMS-3-5 6142815 YP_001745704.1 CDS livM NC_010498.1 3805451 3806728 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit complement(3805451..3806728) Escherichia coli SMS-3-5 6143974 YP_001745705.1 CDS livH NC_010498.1 3806725 3807651 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH complement(3806725..3807651) Escherichia coli SMS-3-5 6145450 YP_001745706.1 CDS livK NC_010498.1 3807699 3808808 R identified by match to protein family HMM PF01094; high-affinity branched-chain amino acid ABC transporter periplasmic leucine-specific-binding protein LivK complement(3807699..3808808) Escherichia coli SMS-3-5 6145055 YP_001745707.1 CDS EcSMS35_3741 NC_010498.1 3808960 3809097 R identified by Glimmer3; putative; hypothetical protein complement(3808960..3809097) Escherichia coli SMS-3-5 6147309 YP_001745708.1 CDS EcSMS35_3742 NC_010498.1 3809232 3809615 D identified by match to protein family HMM PF00583; acetyltransferase 3809232..3809615 Escherichia coli SMS-3-5 6146679 YP_001745709.1 CDS livJ NC_010498.1 3809803 3810906 R identified by match to protein family HMM PF01094; high-affinity branched-chain amino acid ABC transporter periplasmic Leu/Ile/Val-binding protein LivJ complement(3809803..3810906) Escherichia coli SMS-3-5 6145563 YP_001745710.1 CDS rpoH NC_010498.1 3811178 3812032 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(3811178..3812032) Escherichia coli SMS-3-5 6144026 YP_001745711.1 CDS ftsX NC_010498.1 3812277 3813335 R putative ABC transporter, membrane protein; cell division protein FtsX complement(3812277..3813335) Escherichia coli SMS-3-5 6142941 YP_001745712.1 CDS ftsE NC_010498.1 3813328 3813996 R putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(3813328..3813996) Escherichia coli SMS-3-5 6143493 YP_001745713.1 CDS ftsY NC_010498.1 3813999 3815537 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(3813999..3815537) Escherichia coli SMS-3-5 6143446 YP_001745714.1 CDS rsmD NC_010498.1 3815687 3816283 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3815687..3816283 Escherichia coli SMS-3-5 6146335 YP_001745715.1 CDS EcSMS35_3749 NC_010498.1 3816273 3816542 D identified by match to protein family HMM PF06611; hypothetical protein 3816273..3816542 Escherichia coli SMS-3-5 6147319 YP_001745716.1 CDS EcSMS35_3750 NC_010498.1 3816545 3816904 R hypothetical protein complement(3816545..3816904) Escherichia coli SMS-3-5 6145267 YP_001745717.1 CDS EcSMS35_3751 NC_010498.1 3817045 3817671 D identified by match to protein family HMM PF07947; hypothetical protein 3817045..3817671 Escherichia coli SMS-3-5 6144863 YP_001745718.1 CDS zntA NC_010498.1 3817745 3819943 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3817745..3819943 Escherichia coli SMS-3-5 6142828 YP_001745719.1 CDS EcSMS35_3753 NC_010498.1 3819976 3820284 R identified by similarity to GB:ABL00817.1; hypothetical protein complement(3819976..3820284) Escherichia coli SMS-3-5 6142747 YP_001745720.1 CDS tusA NC_010498.1 3820499 3820744 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(3820499..3820744) Escherichia coli SMS-3-5 6143495 YP_001745721.1 CDS EcSMS35_3755 NC_010498.1 3820965 3821630 D identified by match to protein family HMM PF02592; match to protein family HMM TIGR00697; hypothetical protein 3820965..3821630 Escherichia coli SMS-3-5 6147023 YP_001745722.1 CDS EcSMS35_3756 NC_010498.1 3821703 3822260 D hypothetical protein 3821703..3822260 Escherichia coli SMS-3-5 6147115 YP_001745723.1 CDS EcSMS35_3757 NC_010498.1 3822264 3823514 R identified by match to protein family HMM PF07690; major facilitator superfamily transporter complement(3822264..3823514) Escherichia coli SMS-3-5 6144980 YP_001745724.1 CDS EcSMS35_3758 NC_010498.1 3823613 3824662 D identified by match to protein family HMM PF01594; hypothetical protein 3823613..3824662 Escherichia coli SMS-3-5 6145708 YP_001745725.1 CDS acpT NC_010498.1 3824717 3825304 D identified by match to protein family HMM PF01648; holo-(acyl carrier protein) synthase 2 3824717..3825304 Escherichia coli SMS-3-5 6143847 YP_001745726.1 CDS nikA NC_010498.1 3825415 3826989 D identified by match to protein family HMM PF00496; match to protein family HMM TIGR02294; nickel ABC transporter periplasmic nickel-binding protein NikA 3825415..3826989 Escherichia coli SMS-3-5 6144357 YP_001745727.1 CDS nikB NC_010498.1 3826989 3827933 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3826989..3827933 Escherichia coli SMS-3-5 6143337 YP_001745728.1 CDS nikC NC_010498.1 3827930 3828763 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3827930..3828763 Escherichia coli SMS-3-5 6146685 YP_001745729.1 CDS nikD NC_010498.1 3828763 3829527 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3828763..3829527 Escherichia coli SMS-3-5 6142754 YP_001745730.1 CDS nikE NC_010498.1 3829524 3830330 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3829524..3830330 Escherichia coli SMS-3-5 6142647 YP_001745731.1 CDS nikR NC_010498.1 3830336 3830737 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3830336..3830737 Escherichia coli SMS-3-5 6144419 YP_001745732.1 CDS EcSMS35_3766 NC_010498.1 3830936 3831682 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 3830936..3831682 Escherichia coli SMS-3-5 6143819 YP_001745733.1 CDS EcSMS35_3767 NC_010498.1 3831707 3832180 D identified by match to protein family HMM PF00359; PEP-dependent sugar transporting PTS family, IIA component 3831707..3832180 Escherichia coli SMS-3-5 6146042 YP_001745734.1 CDS EcSMS35_3768 NC_010498.1 3832177 3832458 D identified by similarity to SP:P37188; match to protein family HMM PF02302; PEP-dependent sugar transporting PTS family, IIB component 3832177..3832458 Escherichia coli SMS-3-5 6145392 YP_001745735.1 CDS EcSMS35_3769 NC_010498.1 3832532 3833890 D identified by match to protein family HMM PF03611; PEP-dependent sugar transporting PTS family, IIC component 3832532..3833890 Escherichia coli SMS-3-5 6147163 YP_001745736.1 CDS EcSMS35_3770 NC_010498.1 3833883 3835391 D identified by match to protein family HMM PF00370; match to protein family HMM PF02782; carbohydrate kinase 3833883..3835391 Escherichia coli SMS-3-5 6147031 YP_001745737.1 CDS EcSMS35_3771 NC_010498.1 3835381 3835650 D identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; HPr family phosphocarrier protein 3835381..3835650 Escherichia coli SMS-3-5 6146298 YP_001745738.1 CDS gatY NC_010498.1 3835682 3836542 D class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; putative fructose-1,6-bisphosphate aldolase 3835682..3836542 Escherichia coli SMS-3-5 6143086 YP_001745739.1 CDS EcSMS35_3773 NC_010498.1 3836592 3836924 R identified by match to protein family HMM PF05534; HicB family protein complement(3836592..3836924) Escherichia coli SMS-3-5 6147038 YP_001745740.1 CDS EcSMS35_3774 NC_010498.1 3837295 3838419 R identified by match to protein family HMM PF01061; ABC transporter ATP-binding protein complement(3837295..3838419) Escherichia coli SMS-3-5 6146312 YP_001745741.1 CDS EcSMS35_3775 NC_010498.1 3838419 3841154 R identified by match to protein family HMM PF00005; match to protein family HMM PF01061; ABC transporter ATP binding protein complement(3838419..3841154) Escherichia coli SMS-3-5 6143018 YP_001745742.1 CDS EcSMS35_3776 NC_010498.1 3841151 3842218 R identified by match to protein family HMM PF00529; MFP family transporter complement(3841151..3842218) Escherichia coli SMS-3-5 6144857 YP_001745743.1 CDS EcSMS35_3777 NC_010498.1 3842281 3842394 R identified by Glimmer3; putative; hypothetical protein complement(3842281..3842394) Escherichia coli SMS-3-5 6144191 YP_001745744.1 CDS EcSMS35_3778 NC_010498.1 3842584 3844206 R hypothetical protein complement(3842584..3844206) Escherichia coli SMS-3-5 6145933 YP_001745745.1 CDS EcSMS35_3779 NC_010498.1 3844468 3846120 R hypothetical protein complement(3844468..3846120) Escherichia coli SMS-3-5 6145250 YP_001745746.1 CDS EcSMS35_3780 NC_010498.1 3846440 3847492 D hypothetical protein 3846440..3847492 Escherichia coli SMS-3-5 6146895 YP_001745747.1 CDS EcSMS35_3781 NC_010498.1 3847807 3849009 R identified by match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR00275; pyridine nucleotide-disulfide oxidoreductase family protein complement(3847807..3849009) Escherichia coli SMS-3-5 6146209 YP_001745748.1 CDS pitA NC_010498.1 3849241 3850740 D identified by match to protein family HMM PF01384; low-affinity inorganic phosphate transporter 1 3849241..3850740 Escherichia coli SMS-3-5 6143022 YP_001745749.1 CDS uspB NC_010498.1 3850811 3851092 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(3850811..3851092) Escherichia coli SMS-3-5 6145285 YP_001745750.1 CDS uspA NC_010498.1 3851537 3851971 D identified by match to protein family HMM PF00582; universal stress protein A 3851537..3851971 Escherichia coli SMS-3-5 6146387 YP_001745751.1 CDS EcSMS35_3785 NC_010498.1 3852287 3853756 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3852287..3853756 Escherichia coli SMS-3-5 6146935 YP_001745752.1 CDS EcSMS35_3786 NC_010498.1 3853805 3854557 R predicted SAM-dependent methyltransferase; putative methyltransferase complement(3853805..3854557) Escherichia coli SMS-3-5 6146803 YP_001745753.1 CDS prlC NC_010498.1 3854565 3856607 R identified by match to protein family HMM PF01432; oligopeptidase A complement(3854565..3856607) Escherichia coli SMS-3-5 6142652 YP_001745754.1 CDS yhiR NC_010498.1 3856810 3857652 D identified by match to protein family HMM PF04378; DNA utilization protein YhiR 3856810..3857652 Escherichia coli SMS-3-5 6143571 YP_001745755.1 CDS gor NC_010498.1 3857724 3859076 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3857724..3859076 Escherichia coli SMS-3-5 6143863 YP_001745756.1 CDS EcSMS35_3790 NC_010498.1 3859127 3859246 R identified by Glimmer3; putative; hypothetical protein complement(3859127..3859246) Escherichia coli SMS-3-5 6144057 YP_001745757.1 CDS EcSMS35_3791 NC_010498.1 3859241 3859414 D identified by Glimmer3; putative; hypothetical protein 3859241..3859414 Escherichia coli SMS-3-5 6144839 YP_001745758.1 CDS EcSMS35_3792 NC_010498.1 3859738 3859851 R identified by Glimmer3; putative; hypothetical protein complement(3859738..3859851) Escherichia coli SMS-3-5 6145672 YP_001745759.1 CDS arsR NC_010498.1 3859954 3860307 D regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3859954..3860307 Escherichia coli SMS-3-5 6146554 YP_001745760.1 CDS arsB NC_010498.1 3860362 3861651 D identified by match to protein family HMM PF02040; match to protein family HMM PF03600; match to protein family HMM TIGR00935; arsenical pump membrane protein 3860362..3861651 Escherichia coli SMS-3-5 6146139 YP_001745761.1 CDS arsC NC_010498.1 3861664 3862089 D identified by match to protein family HMM PF03960; match to protein family HMM TIGR00014; arsenate reductase 3861664..3862089 Escherichia coli SMS-3-5 6142935 YP_001745762.1 CDS EcSMS35_3796 NC_010498.1 3862110 3862430 R identified by match to protein family HMM PF01022; ArsR family transcriptional regulator complement(3862110..3862430) Escherichia coli SMS-3-5 6142659 YP_001745763.1 CDS EcSMS35_3797 NC_010498.1 3862537 3863538 D identified by match to protein family HMM PF03773; putative permease 3862537..3863538 Escherichia coli SMS-3-5 6143192 YP_001745764.1 CDS EcSMS35_3798 NC_010498.1 3864118 3865341 D hypothetical protein 3864118..3865341 Escherichia coli SMS-3-5 6144130 YP_001745765.1 CDS EcSMS35_3799 NC_010498.1 3865431 3866153 D identified by match to protein family HMM PF03843; match to protein family HMM TIGR00752; Slp family outer membrane lipoprotein 3865431..3866153 Escherichia coli SMS-3-5 6144650 YP_001745766.1 CDS dctR NC_010498.1 3866306 3866836 D identified by match to protein family HMM PF00196; transcriptional regulator DctR 3866306..3866836 Escherichia coli SMS-3-5 6144395 YP_001745767.1 CDS hmuS NC_010498.1 3866897 3867925 R identified by similarity to SP:Q56990; match to protein family HMM PF05171; hemin transport protein HmuS complement(3866897..3867925) Escherichia coli SMS-3-5 6145970 YP_001745768.1 CDS chuA NC_010498.1 3867974 3869956 R identified by similarity to GB:AAC27809.1; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01785; match to protein family HMM TIGR01786; outer membrane heme/hemoglobin receptor ChuA complement(3867974..3869956) Escherichia coli SMS-3-5 6146648 YP_001745769.1 CDS EcSMS35_3803 NC_010498.1 3870325 3870486 D identified by Glimmer3; putative; hypothetical protein 3870325..3870486 Escherichia coli SMS-3-5 6145477 YP_001745770.1 CDS EcSMS35_3804 NC_010498.1 3870640 3871554 D identified by match to protein family HMM PF01497; periplasmic-binding protein 3870640..3871554 Escherichia coli SMS-3-5 6146000 YP_001745771.1 CDS EcSMS35_3805 NC_010498.1 3871574 3872911 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3871574..3872911 Escherichia coli SMS-3-5 6144110 YP_001745772.1 CDS EcSMS35_3806 NC_010498.1 3872924 3873418 D identified by match to protein family HMM PF06228; hypothetical protein 3872924..3873418 Escherichia coli SMS-3-5 6144649 YP_001745773.1 CDS EcSMS35_3807 NC_010498.1 3873418 3874041 D identified by similarity to GB:CAG75906.1; hypothetical protein 3873418..3874041 Escherichia coli SMS-3-5 6146946 YP_001745774.1 CDS EcSMS35_3808 NC_010498.1 3874090 3875082 D identified by match to protein family HMM PF01032; iron chelate ABC transporter permease 3874090..3875082 Escherichia coli SMS-3-5 6143448 YP_001745775.1 CDS hmuV NC_010498.1 3875049 3875849 D with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 3875049..3875849 Escherichia coli SMS-3-5 6146505 YP_001745776.1 CDS EcSMS35_3810 NC_010498.1 3875901 3876560 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase complement(3875901..3876560) Escherichia coli SMS-3-5 6147327 YP_001745777.1 CDS hdeB NC_010498.1 3876612 3876950 R acid-resistance protein complement(3876612..3876950) Escherichia coli SMS-3-5 6144769 YP_001745778.1 CDS EcSMS35_3812 NC_010498.1 3877054 3877386 R inactive form; acid-resistance protein complement(3877054..3877386) Escherichia coli SMS-3-5 6144996 YP_001745779.1 CDS EcSMS35_3813 NC_010498.1 3877668 3878213 D acid-resistance membrane protein 3877668..3878213 Escherichia coli SMS-3-5 6144775 YP_001745780.1 CDS gadE NC_010498.1 3879011 3879538 D transcriptional regulator GadE 3879011..3879538 Escherichia coli SMS-3-5 6145350 YP_001745781.1 CDS EcSMS35_3815 NC_010498.1 3879855 3879947 R identified by Glimmer3; putative; hypothetical protein complement(3879855..3879947) Escherichia coli SMS-3-5 6143349 YP_001745782.1 CDS mdtE NC_010498.1 3879877 3881034 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3879877..3881034 Escherichia coli SMS-3-5 6143911 YP_001745783.1 CDS mdtF NC_010498.1 3881059 3884172 D identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915; multidrug resistance protein MdtF 3881059..3884172 Escherichia coli SMS-3-5 6146253 YP_001745784.1 CDS gadW NC_010498.1 3884535 3885263 R identified by match to protein family HMM PF00165; transcriptional regulator GadW complement(3884535..3885263) Escherichia coli SMS-3-5 6146613 YP_001745785.1 CDS gadX NC_010498.1 3885632 3886456 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(3885632..3886456) Escherichia coli SMS-3-5 6144804 YP_001745786.1 CDS gadB NC_010498.1 3886816 3888216 R identified by match to protein family HMM PF00282; match to protein family HMM TIGR01788; glutamate decarboxylase GadB complement(3886816..3888216) Escherichia coli SMS-3-5 6145366 YP_001745787.1 CDS EcSMS35_3821 NC_010498.1 3888427 3889824 R identified by match to protein family HMM PF03150; di-heme cytochrome c peroxidase family protein complement(3888427..3889824) Escherichia coli SMS-3-5 6144046 YP_001745788.1 CDS EcSMS35_3822 NC_010498.1 3890005 3890124 D identified by Glimmer3; putative; hypothetical protein 3890005..3890124 Escherichia coli SMS-3-5 6144540 YP_001745789.1 CDS treF NC_010498.1 3890229 3891878 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3890229..3891878 Escherichia coli SMS-3-5 6143525 YP_001745790.1 CDS EcSMS35_3824 NC_010498.1 3891929 3892531 R identified by match to protein family HMM PF00196; match to protein family HMM PF08281; LuxR family transcriptional regulator complement(3891929..3892531) Escherichia coli SMS-3-5 6144469 YP_001745791.1 CDS EcSMS35_3825 NC_010498.1 3892979 3893950 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3892979..3893950 Escherichia coli SMS-3-5 6147080 YP_001745792.1 CDS EcSMS35_3826 NC_010498.1 3893999 3895012 D yhjD; identified by match to protein family HMM PF03631; match to protein family HMM TIGR00766; putative ribonuclease 3893999..3895012 Escherichia coli SMS-3-5 6146684 YP_001745793.1 CDS EcSMS35_3827 NC_010498.1 3895404 3896726 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; MFS transporter, metabolite:H+ symporter (MHS) family protein 3895404..3896726 Escherichia coli SMS-3-5 6145775 YP_001745794.1 CDS EcSMS35_3828 NC_010498.1 3896905 3898965 R identified by match to protein family HMM PF05170; AsmA family protein complement(3896905..3898965) Escherichia coli SMS-3-5 6145094 YP_001745795.1 CDS EcSMS35_3829 NC_010498.1 3899035 3899649 R in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein complement(3899035..3899649) Escherichia coli SMS-3-5 6144409 YP_001745796.1 CDS EcSMS35_3830 NC_010498.1 3899875 3899997 R identified by Glimmer3; putative; hypothetical protein complement(3899875..3899997) Escherichia coli SMS-3-5 6143744 YP_001745797.1 CDS kdgK NC_010498.1 3900034 3900963 D identified by match to protein family HMM PF00294; 2-dehydro-3-deoxygluconokinase 3900034..3900963 Escherichia coli SMS-3-5 6147400 YP_001745798.1 CDS EcSMS35_3832 NC_010498.1 3901058 3902263 D identified by similarity to GB:CAK15512.1; hypothetical protein 3901058..3902263 Escherichia coli SMS-3-5 6143155 YP_001745799.1 CDS EcSMS35_3834 NC_010498.1 3902250 3904292 D identified by similarity to GB:AAY95391.1; hypothetical protein 3902250..3904292 Escherichia coli SMS-3-5 6144737 YP_001745800.1 CDS EcSMS35_3833 NC_010498.1 3904270 3904800 R putative lipoprotein complement(3904270..3904800) Escherichia coli SMS-3-5 6144008 YP_001745801.1 CDS EcSMS35_3835 NC_010498.1 3904983 3906479 R identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16 family peptidase complement(3904983..3906479) Escherichia coli SMS-3-5 6145279 YP_001745802.1 CDS dctA NC_010498.1 3906699 3907985 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(3906699..3907985) Escherichia coli SMS-3-5 6146394 YP_001745803.1 CDS EcSMS35_3837 NC_010498.1 3907989 3908087 D identified by Glimmer3; putative; hypothetical protein 3907989..3908087 Escherichia coli SMS-3-5 6146811 YP_001745804.1 CDS EcSMS35_3838 NC_010498.1 3908168 3910117 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase complement(3908168..3910117) Escherichia coli SMS-3-5 6147336 YP_001745805.1 CDS EcSMS35_3839 NC_010498.1 3910238 3913711 R cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC complement(3910238..3913711) Escherichia coli SMS-3-5 6143599 YP_001745806.1 CDS bcsZ NC_010498.1 3913693 3914805 R catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase complement(3913693..3914805) Escherichia coli SMS-3-5 6144897 YP_001745807.1 CDS bcsB NC_010498.1 3914806 3917115 R binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein complement(3914806..3917115) Escherichia coli SMS-3-5 6147347 YP_001745808.1 CDS bcsA NC_010498.1 3917156 3919774 R polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit complement(3917156..3919774) Escherichia coli SMS-3-5 6145598 YP_001745809.1 CDS EcSMS35_3843 NC_010498.1 3919771 3920523 R identified by match to protein family HMM PF06564; match to protein family HMM TIGR03371; cell division protein complement(3919771..3920523) Escherichia coli SMS-3-5 6144136 YP_001745810.1 CDS EcSMS35_3844 NC_010498.1 3920535 3920723 R hypothetical protein complement(3920535..3920723) Escherichia coli SMS-3-5 6143167 YP_001745811.1 CDS EcSMS35_3845 NC_010498.1 3921007 3922566 D identified by match to protein family HMM TIGR03369; hypothetical protein 3921007..3922566 Escherichia coli SMS-3-5 6142610 YP_001745812.1 CDS bcsF NC_010498.1 3922563 3922754 D cellulose biosynthesis protein BcsF 3922563..3922754 Escherichia coli SMS-3-5 6146693 YP_001745813.1 CDS EcSMS35_3847 NC_010498.1 3922751 3924430 D identified by match to protein family HMM TIGR03368; hypothetical protein 3922751..3924430 Escherichia coli SMS-3-5 6146221 YP_001745814.1 CDS EcSMS35_3848 NC_010498.1 3924517 3924684 R identified by similarity to RF:NP_458295.1; hypothetical protein complement(3924517..3924684) Escherichia coli SMS-3-5 6145297 YP_001745815.1 CDS EcSMS35_3849 NC_010498.1 3924865 3924996 D identified by Glimmer3; putative; hypothetical protein 3924865..3924996 Escherichia coli SMS-3-5 6147210 YP_001745816.1 CDS EcSMS35_3850 NC_010498.1 3925001 3925168 R hypothetical protein complement(3925001..3925168) Escherichia coli SMS-3-5 6144164 YP_001745817.1 CDS EcSMS35_3851 NC_010498.1 3925293 3925469 D identified by Glimmer3; putative; hypothetical protein 3925293..3925469 Escherichia coli SMS-3-5 6145847 YP_001745818.1 CDS EcSMS35_3852 NC_010498.1 3925485 3925652 R identified by Glimmer3; putative; hypothetical protein complement(3925485..3925652) Escherichia coli SMS-3-5 6142660 YP_001745819.1 CDS EcSMS35_3853 NC_010498.1 3925777 3925953 D identified by Glimmer3; putative; hypothetical protein 3925777..3925953 Escherichia coli SMS-3-5 6145474 YP_001745820.1 CDS EcSMS35_3854 NC_010498.1 3925969 3926136 R hypothetical protein complement(3925969..3926136) Escherichia coli SMS-3-5 6144654 YP_001745821.1 CDS EcSMS35_3855 NC_010498.1 3926316 3926447 D identified by Glimmer3; putative; hypothetical protein 3926316..3926447 Escherichia coli SMS-3-5 6144158 YP_001745822.1 CDS EcSMS35_3856 NC_010498.1 3926452 3926619 R hypothetical protein complement(3926452..3926619) Escherichia coli SMS-3-5 6143350 YP_001745823.1 CDS EcSMS35_3857 NC_010498.1 3926634 3926804 D identified by Glimmer3; putative; hypothetical protein 3926634..3926804 Escherichia coli SMS-3-5 6144605 YP_001745824.1 CDS EcSMS35_3858 NC_010498.1 3927035 3928306 D identified by match to protein family HMM TIGR00814; serine transporter family protein 3927035..3928306 Escherichia coli SMS-3-5 6147299 YP_001745825.1 CDS dppF NC_010498.1 3928336 3929340 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(3928336..3929340) Escherichia coli SMS-3-5 6146528 YP_001745826.1 CDS dppD NC_010498.1 3929337 3930320 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(3929337..3930320) Escherichia coli SMS-3-5 6144962 YP_001745827.1 CDS dppC NC_010498.1 3930331 3931233 R identified by match to protein family HMM PF00528; dipeptide transporter complement(3930331..3931233) Escherichia coli SMS-3-5 6147037 YP_001745828.1 CDS dppB NC_010498.1 3931243 3932262 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(3931243..3932262) Escherichia coli SMS-3-5 6144257 YP_001745829.1 CDS EcSMS35_3864 NC_010498.1 3932280 3932423 D identified by Glimmer3; putative; hypothetical protein 3932280..3932423 Escherichia coli SMS-3-5 6145379 YP_001745830.1 CDS dppA NC_010498.1 3932413 3934020 R identified by match to protein family HMM PF00496; dipeptide ABC transporter periplasmic dipeptide-binding protein complement(3932413..3934020) Escherichia coli SMS-3-5 6144283 YP_001745831.1 CDS EcSMS35_3865 NC_010498.1 3934372 3934635 R identified by Glimmer3; putative; hypothetical protein complement(3934372..3934635) Escherichia coli SMS-3-5 6143781 YP_001745832.1 CDS EcSMS35_3867 NC_010498.1 3934932 3936623 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(3934932..3936623) Escherichia coli SMS-3-5 6143697 YP_001745833.1 CDS EcSMS35_3868 NC_010498.1 3936947 3938155 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00890; major facilitator family transporter complement(3936947..3938155) Escherichia coli SMS-3-5 6146825 YP_001745834.1 CDS EcSMS35_3869 NC_010498.1 3938384 3939082 R hypothetical protein complement(3938384..3939082) Escherichia coli SMS-3-5 6146460 YP_001745835.1 CDS tag NC_010498.1 3939240 3939803 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 3939240..3939803 Escherichia coli SMS-3-5 6145754 YP_001745836.1 CDS EcSMS35_3872 NC_010498.1 3939800 3940240 D identified by match to protein family HMM PF00583; hypothetical protein 3939800..3940240 Escherichia coli SMS-3-5 6146902 YP_001745837.1 CDS bisC NC_010498.1 3940209 3942542 R identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; biotin sulfoxide reductase complement(3940209..3942542) Escherichia coli SMS-3-5 6145520 YP_001745838.1 CDS EcSMS35_3873 NC_010498.1 3942695 3943354 D identified by match to protein family HMM PF00691; match to protein family HMM PF05433; putative outer membrane lipoprotein 3942695..3943354 Escherichia coli SMS-3-5 6145316 YP_001745839.1 CDS tkrA NC_010498.1 3943458 3944432 D identified by match to protein family HMM PF00389; match to protein family HMM PF02826; 2-ketogluconate reductase 3943458..3944432 Escherichia coli SMS-3-5 6145008 YP_001745840.1 CDS EcSMS35_3875 NC_010498.1 3944482 3945192 R putative lipoprotein complement(3944482..3945192) Escherichia coli SMS-3-5 6144323 YP_001745841.1 CDS EcSMS35_3876 NC_010498.1 3945626 3945916 D putative transcriptional regulator 3945626..3945916 Escherichia coli SMS-3-5 6144800 YP_001745842.1 CDS EcSMS35_3877 NC_010498.1 3946197 3946409 D identified by match to protein family HMM PF00313; major cold shock protein 3946197..3946409 Escherichia coli SMS-3-5 6144267 YP_001745843.1 CDS hokA NC_010498.1 3946598 3946750 R identified by match to protein family HMM PF01848; small toxic polypeptide complement(3946598..3946750) Escherichia coli SMS-3-5 6143028 YP_001745844.1 CDS EcSMS35_3879 NC_010498.1 3946830 3947351 D IS150 transposase orfA 3946830..3947351 Escherichia coli SMS-3-5 6147430 YP_001745845.1 CDS EcSMS35_3880 NC_010498.1 3947348 3948199 D identified by match to protein family HMM PF00665; IS150 transposase orfB 3947348..3948199 Escherichia coli SMS-3-5 6146900 YP_001745846.1 CDS glyS NC_010498.1 3948477 3950546 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(3948477..3950546) Escherichia coli SMS-3-5 6142855 YP_001745847.1 CDS glyQ NC_010498.1 3950556 3951467 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(3950556..3951467) Escherichia coli SMS-3-5 6147154 YP_001745848.1 CDS EcSMS35_3883 NC_010498.1 3951562 3951870 R hypothetical protein complement(3951562..3951870) Escherichia coli SMS-3-5 6143104 YP_001745849.1 CDS EcSMS35_3884 NC_010498.1 3952045 3953040 D acyltransferase family protein 3952045..3953040 Escherichia coli SMS-3-5 6143397 YP_001745850.1 CDS EcSMS35_3885 NC_010498.1 3953082 3953519 R identified by match to protein family HMM PF05360; hypothetical protein complement(3953082..3953519) Escherichia coli SMS-3-5 6144168 YP_001745851.1 CDS EcSMS35_3886 NC_010498.1 3953565 3953906 R identified by match to protein family HMM PF05360; hypothetical protein complement(3953565..3953906) Escherichia coli SMS-3-5 6144103 YP_001745852.1 CDS xylB NC_010498.1 3954075 3955529 R identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR01312; xylulokinase complement(3954075..3955529) Escherichia coli SMS-3-5 6144582 YP_001745853.1 CDS xylA NC_010498.1 3955601 3956923 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(3955601..3956923) Escherichia coli SMS-3-5 6145005 YP_001745854.1 CDS xylF NC_010498.1 3957289 3958281 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 3957289..3958281 Escherichia coli SMS-3-5 6145527 YP_001745855.1 CDS xylG NC_010498.1 3958359 3959900 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 3958359..3959900 Escherichia coli SMS-3-5 6146741 YP_001745856.1 CDS xylH NC_010498.1 3959878 3961059 D identified by match to protein family HMM PF02653; D-xylose ABC transporter permease 3959878..3961059 Escherichia coli SMS-3-5 6147286 YP_001745857.1 CDS xylR NC_010498.1 3961137 3962315 D identified by match to protein family HMM PF00165; xylose operon regulatory protein 3961137..3962315 Escherichia coli SMS-3-5 6142912 YP_001745858.1 CDS bax NC_010498.1 3962423 3963247 R identified by match to protein family HMM PF01832; hypothetical protein complement(3962423..3963247) Escherichia coli SMS-3-5 6146339 YP_001745859.1 CDS malS NC_010498.1 3963567 3965597 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase precursor 3963567..3965597 Escherichia coli SMS-3-5 6142972 YP_001745860.1 CDS avtA NC_010498.1 3965775 3967028 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 3965775..3967028 Escherichia coli SMS-3-5 6143413 YP_001745861.1 CDS EcSMS35_3896 NC_010498.1 3967180 3967653 R identified by match to protein family HMM PF00037; 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein complement(3967180..3967653) Escherichia coli SMS-3-5 6142957 YP_001745862.1 CDS EcSMS35_3897 NC_010498.1 3967755 3968603 R identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator complement(3967755..3968603) Escherichia coli SMS-3-5 6143188 YP_001745863.1 CDS dlgD NC_010498.1 3968804 3969802 D NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 3968804..3969802 Escherichia coli SMS-3-5 6144299 YP_001745864.1 CDS EcSMS35_3899 NC_010498.1 3969814 3970281 D identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 3969814..3970281 Escherichia coli SMS-3-5 6144845 YP_001745865.1 CDS EcSMS35_3900 NC_010498.1 3970399 3970872 D membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 3970399..3970872 Escherichia coli SMS-3-5 6145915 YP_001745866.1 CDS EcSMS35_3901 NC_010498.1 3970875 3972152 D identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter, DctM subunit 3970875..3972152 Escherichia coli SMS-3-5 6146605 YP_001745867.1 CDS EcSMS35_3902 NC_010498.1 3972165 3973151 D identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein 3972165..3973151 Escherichia coli SMS-3-5 6146397 YP_001745868.1 CDS lyx NC_010498.1 3973155 3974651 D identified by match to protein family HMM PF00370; match to protein family HMM PF02782; cryptic L-xylulose kinase 3973155..3974651 Escherichia coli SMS-3-5 6143850 YP_001745869.1 CDS sgbH NC_010498.1 3974648 3975310 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 3974648..3975310 Escherichia coli SMS-3-5 6144064 YP_001745870.1 CDS EcSMS35_3905 NC_010498.1 3975303 3976163 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 3975303..3976163 Escherichia coli SMS-3-5 6143581 YP_001745871.1 CDS sgbE NC_010498.1 3976157 3976852 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 3976157..3976852 Escherichia coli SMS-3-5 6147141 YP_001745872.1 CDS EcSMS35_3907 NC_010498.1 3976884 3977699 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(3976884..3977699) Escherichia coli SMS-3-5 6146463 YP_001745873.1 CDS EcSMS35_3908 NC_010498.1 3977925 3979325 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00792; sugar glycoside-pentoside-hexuronide family protein 3977925..3979325 Escherichia coli SMS-3-5 6145753 YP_001745874.1 CDS EcSMS35_3909 NC_010498.1 3979336 3981306 D identified by similarity to GB:CAD07947.1; match to protein family HMM PF07944; hypothetical protein 3979336..3981306 Escherichia coli SMS-3-5 6145085 YP_001745875.1 CDS EcSMS35_3910 NC_010498.1 3981436 3982176 R identified by match to protein family HMM PF06629; MltA-interacting protein MipA complement(3981436..3982176) Escherichia coli SMS-3-5 6146093 YP_001745876.1 CDS EcSMS35_3912 NC_010498.1 3982300 3983274 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3982300..3983274 Escherichia coli SMS-3-5 6144417 YP_001745877.1 CDS EcSMS35_3911 NC_010498.1 3983271 3984407 R identified by match to protein family HMM PF00529; membrane fusion protein family protein complement(3983271..3984407) Escherichia coli SMS-3-5 6146208 YP_001745878.1 CDS EcSMS35_3913 NC_010498.1 3984413 3984736 R hypothetical protein complement(3984413..3984736) Escherichia coli SMS-3-5 6144636 YP_001745879.1 CDS EcSMS35_3914 NC_010498.1 3984918 3985061 D identified by Glimmer3; putative; hypothetical protein 3984918..3985061 Escherichia coli SMS-3-5 6142752 YP_001745880.1 CDS aldB NC_010498.1 3985280 3986818 R identified by match to protein family HMM PF00171; aldehyde dehydrogenase B complement(3985280..3986818) Escherichia coli SMS-3-5 6143619 YP_001745881.1 CDS EcSMS35_3916 NC_010498.1 3986926 3988221 R identified by match to protein family HMM PF02661; Fic family protein complement(3986926..3988221) Escherichia coli SMS-3-5 6143990 YP_001745882.1 CDS adhB NC_010498.1 3988351 3989502 R identified by match to protein family HMM PF00465; putative alcohol dehydrogenase complement(3988351..3989502) Escherichia coli SMS-3-5 6144714 YP_001745883.1 CDS selB NC_010498.1 3989693 3991537 R identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM PF09106; match to protein family HMM PF09107; match to protein family HMM TIGR00475; selenocysteinyl-tRNA-specific translation factor complement(3989693..3991537) Escherichia coli SMS-3-5 6144997 YP_001745884.1 CDS selA NC_010498.1 3991534 3992925 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(3991534..3992925) Escherichia coli SMS-3-5 6145567 YP_001745885.1 CDS EcSMS35_3920 NC_010498.1 3993023 3993631 R yibF; identified by match to protein family HMM PF00043; match to protein family HMM PF02798; putative glutathione S-transferase complement(3993023..3993631) Escherichia coli SMS-3-5 6145032 YP_001745886.1 CDS EcSMS35_3921 NC_010498.1 3993788 3997597 R identified by match to protein family HMM PF02395; match to protein family HMM PF03797; match to protein family HMM TIGR01414; outer membrane autotransporter complement(3993788..3997597) Escherichia coli SMS-3-5 6145561 YP_001745887.1 CDS EcSMS35_3922 NC_010498.1 3997769 3998287 R identified by similarity to SP:P20862; putative fimbrial protein FanH complement(3997769..3998287) Escherichia coli SMS-3-5 6147092 YP_001745888.1 CDS EcSMS35_3923 NC_010498.1 3998280 3998702 R putative fimbrial protein FanG complement(3998280..3998702) Escherichia coli SMS-3-5 6145642 YP_001745889.1 CDS EcSMS35_3924 NC_010498.1 3998815 3999786 R putative fimbrial protein FanF complement(3998815..3999786) Escherichia coli SMS-3-5 6143526 YP_001745890.1 CDS EcSMS35_3925 NC_010498.1 3999816 4000496 R identified by match to protein family HMM PF00345; match to protein family HMM PF02753; putative fimbrial assembly chaperone FanE complement(3999816..4000496) Escherichia coli SMS-3-5 6146710 YP_001745891.1 CDS EcSMS35_3926 NC_010498.1 4000504 4002861 R identified by match to protein family HMM PF00577; putative fimbrial usher protein FanD complement(4000504..4002861) Escherichia coli SMS-3-5 6143802 YP_001745892.1 CDS EcSMS35_3927 NC_010498.1 4002933 4003460 R identified by match to protein family HMM PF00419; putative fimbrial protein FanC complement(4002933..4003460) Escherichia coli SMS-3-5 6145634 YP_001745893.1 CDS EcSMS35_3928 NC_010498.1 4004205 4004711 D identified by match to protein family HMM PF08281; sigma-70 domain-containing protein 4004205..4004711 Escherichia coli SMS-3-5 6144543 YP_001745894.1 CDS EcSMS35_3929 NC_010498.1 4004902 4005732 D identified by match to protein family HMM PF00165; putative fimbrial operon positive regulatory protein FanR 4004902..4005732 Escherichia coli SMS-3-5 6147260 YP_001745895.1 CDS EcSMS35_3930 NC_010498.1 4005888 4007024 R identified by match to protein family HMM PF00529; auxiliary membrane fusion protein family transporter complement(4005888..4007024) Escherichia coli SMS-3-5 6146715 YP_001745896.1 CDS EcSMS35_3931 NC_010498.1 4007027 4007491 R hypothetical protein complement(4007027..4007491) Escherichia coli SMS-3-5 6146667 YP_001745897.1 CDS mtlA NC_010498.1 4007925 4009838 D identified by match to protein family HMM PF00359; match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; PTS system, mannitol-specific IIABC component 4007925..4009838 Escherichia coli SMS-3-5 6143302 YP_001745898.1 CDS mtlD NC_010498.1 4009933 4011081 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 4009933..4011081 Escherichia coli SMS-3-5 6142775 YP_001745899.1 CDS mtlR NC_010498.1 4011081 4011668 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 4011081..4011668 Escherichia coli SMS-3-5 6145455 YP_001745900.1 CDS EcSMS35_3935 NC_010498.1 4011679 4011888 R hypothetical protein complement(4011679..4011888) Escherichia coli SMS-3-5 6144627 YP_001745901.1 CDS EcSMS35_3936 NC_010498.1 4012172 4012534 D hypothetical protein 4012172..4012534 Escherichia coli SMS-3-5 6144111 YP_001745902.1 CDS EcSMS35_3937 NC_010498.1 4012790 4013017 R identified by Glimmer3; putative; hypothetical protein complement(4012790..4013017) Escherichia coli SMS-3-5 6143173 YP_001745903.1 CDS EcSMS35_3938 NC_010498.1 4013092 4013775 D putative lipoprotein 4013092..4013775 Escherichia coli SMS-3-5 6142635 YP_001745904.1 CDS EcSMS35_3939 NC_010498.1 4013819 4018468 D identified by match to protein family HMM PF03895; match to protein family HMM PF05658; match to protein family HMM PF05662; hemagluttinin family protein 4013819..4018468 Escherichia coli SMS-3-5 6146732 YP_001745905.1 CDS lldP NC_010498.1 4018766 4020421 D identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795; L-lactate permease 4018766..4020421 Escherichia coli SMS-3-5 6143557 YP_001745906.1 CDS EcSMS35_3941 NC_010498.1 4020421 4021197 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4020421..4021197 Escherichia coli SMS-3-5 6145302 YP_001745907.1 CDS lldD NC_010498.1 4021194 4022384 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4021194..4022384 Escherichia coli SMS-3-5 6147041 YP_001745908.1 CDS EcSMS35_3943 NC_010498.1 4022432 4022905 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 4022432..4022905 Escherichia coli SMS-3-5 6144093 YP_001745909.1 CDS cysE NC_010498.1 4022958 4023779 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(4022958..4023779) Escherichia coli SMS-3-5 6144325 YP_001745910.1 CDS gpsA NC_010498.1 4023859 4024878 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(4023859..4024878) Escherichia coli SMS-3-5 6146824 YP_001745911.1 CDS secB NC_010498.1 4024878 4025345 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(4024878..4025345) Escherichia coli SMS-3-5 6147355 YP_001745912.1 CDS grxC NC_010498.1 4025408 4025659 R identified by match to protein family HMM PF00462; match to protein family HMM TIGR02181; glutaredoxin 3 complement(4025408..4025659) Escherichia coli SMS-3-5 6146098 YP_001745913.1 CDS EcSMS35_3948 NC_010498.1 4025801 4026232 R identified by match to protein family HMM PF00581; rhodanese domain-containing protein complement(4025801..4026232) Escherichia coli SMS-3-5 6146533 YP_001745914.1 CDS gpmI NC_010498.1 4026477 4028021 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4026477..4028021 Escherichia coli SMS-3-5 6144142 YP_001745915.1 CDS EcSMS35_3950 NC_010498.1 4028055 4029314 D identified by match to protein family HMM PF01551; hypothetical protein 4028055..4029314 Escherichia coli SMS-3-5 6145382 YP_001745916.1 CDS EcSMS35_3952 NC_010498.1 4029318 4030277 D identified by match to protein family HMM PF04748; polysaccharide deacetylase family protein 4029318..4030277 Escherichia coli SMS-3-5 6143539 YP_001745917.1 CDS EcSMS35_3951 NC_010498.1 4030264 4031298 R identified by match to protein family HMM PF00535; putative glycosyl transferase complement(4030264..4031298) Escherichia coli SMS-3-5 6147352 YP_001745918.1 CDS tdh NC_010498.1 4031537 4032562 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(4031537..4032562) Escherichia coli SMS-3-5 6143740 YP_001745919.1 CDS kbl NC_010498.1 4032572 4033768 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase complement(4032572..4033768) Escherichia coli SMS-3-5 6143133 YP_001745920.1 CDS EcSMS35_3955 NC_010498.1 4033814 4033963 R identified by Glimmer3; putative; hypothetical protein complement(4033814..4033963) Escherichia coli SMS-3-5 6146315 YP_001745921.1 CDS rfaD NC_010498.1 4033982 4034914 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 4033982..4034914 Escherichia coli SMS-3-5 6147033 YP_001745922.1 CDS rfaF NC_010498.1 4034924 4035970 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 4034924..4035970 Escherichia coli SMS-3-5 6147338 YP_001745923.1 CDS rfaC NC_010498.1 4035974 4036945 D identified by match to protein family HMM PF01075; match to protein family HMM TIGR02193; ADP-heptose:LPS heptosyl transferase I 4035974..4036945 Escherichia coli SMS-3-5 6143135 YP_001745924.1 CDS EcSMS35_3959 NC_010498.1 4037015 4038268 R identified by match to protein family HMM PF04932; O-antigen polymerase complement(4037015..4038268) Escherichia coli SMS-3-5 6146274 YP_001745925.1 CDS EcSMS35_3960 NC_010498.1 4038314 4039297 R identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(4038314..4039297) Escherichia coli SMS-3-5 6146977 YP_001745926.1 CDS waaW NC_010498.1 4039379 4040407 R identified by match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,2-galactosyltransferase complement(4039379..4040407) Escherichia coli SMS-3-5 6145798 YP_001745927.1 CDS rfaY NC_010498.1 4040433 4041125 R identified by match to protein family HMM PF06176; lipopolysaccharide core biosynthesis protein complement(4040433..4041125) Escherichia coli SMS-3-5 6146378 YP_001745928.1 CDS rfaJ2 NC_010498.1 4041135 4042130 R identified by match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,2-glucosyltransferase complement(4041135..4042130) Escherichia coli SMS-3-5 6144753 YP_001745929.1 CDS rfaI NC_010498.1 4042147 4043163 R identified by match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,3-galactosyltransferase complement(4042147..4043163) Escherichia coli SMS-3-5 6143989 YP_001745930.1 CDS rfaP NC_010498.1 4043179 4043976 R identified by match to protein family HMM PF06293; lipopolysaccharide core biosynthesis protein RfaP complement(4043179..4043976) Escherichia coli SMS-3-5 6145467 YP_001745931.1 CDS rfaG NC_010498.1 4043969 4045093 R identified by match to protein family HMM PF00534; lipopolysaccharide core biosynthesis protein RfaG complement(4043969..4045093) Escherichia coli SMS-3-5 6145985 YP_001745932.1 CDS rfaQ NC_010498.1 4045090 4046148 R identified by match to protein family HMM PF01075; match to protein family HMM TIGR02201; lipopolysaccharide core biosynthesis protein complement(4045090..4046148) Escherichia coli SMS-3-5 6146256 YP_001745933.1 CDS waaA NC_010498.1 4046561 4047838 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4046561..4047838 Escherichia coli SMS-3-5 6146786 YP_001745934.1 CDS coaD NC_010498.1 4047846 4048325 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4047846..4048325 Escherichia coli SMS-3-5 6146332 YP_001745935.1 CDS mutM NC_010498.1 4048364 4049173 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(4048364..4049173) Escherichia coli SMS-3-5 6146724 YP_001745936.1 CDS rpmG NC_010498.1 4049271 4049438 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(4049271..4049438) Escherichia coli SMS-3-5 6143352 YP_001745937.1 CDS rpmB NC_010498.1 4049459 4049695 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(4049459..4049695) Escherichia coli SMS-3-5 6143112 YP_001745938.1 CDS radC NC_010498.1 4049912 4050580 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(4049912..4050580) Escherichia coli SMS-3-5 6144789 YP_001745939.1 CDS coaBC NC_010498.1 4050752 4051972 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4050752..4051972 Escherichia coli SMS-3-5 6146294 YP_001745940.1 CDS dut NC_010498.1 4051950 4052408 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4051950..4052408 Escherichia coli SMS-3-5 6146695 YP_001745941.1 CDS slmA NC_010498.1 4052515 4053111 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4052515..4053111 Escherichia coli SMS-3-5 6147256 YP_001745942.1 CDS pyrE NC_010498.1 4053148 4053789 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(4053148..4053789) Escherichia coli SMS-3-5 6143416 YP_001745943.1 CDS rph NC_010498.1 4053855 4054571 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(4053855..4054571) Escherichia coli SMS-3-5 6144068 YP_001745944.1 CDS EcSMS35_3979 NC_010498.1 4054698 4055561 D yicC; identified by match to protein family HMM PF03755; match to protein family HMM PF08340; match to protein family HMM TIGR00255; hypothetical protein 4054698..4055561 Escherichia coli SMS-3-5 6144670 YP_001745945.1 CDS dinD NC_010498.1 4055783 4056607 D identified by similarity to SP:P23840; DNA-damage-inducible protein D 4055783..4056607 Escherichia coli SMS-3-5 6145091 YP_001745946.1 CDS EcSMS35_3982 NC_010498.1 4056898 4057515 D identified by match to protein family HMM PF03458; hypothetical protein 4056898..4057515 Escherichia coli SMS-3-5 6144503 YP_001745947.1 CDS ligB NC_010498.1 4057512 4059194 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(4057512..4059194) Escherichia coli SMS-3-5 6143314 YP_001745948.1 CDS gmk NC_010498.1 4059452 4060075 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4059452..4060075 Escherichia coli SMS-3-5 6145309 YP_001745949.1 CDS rpoZ NC_010498.1 4060130 4060405 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4060130..4060405 Escherichia coli SMS-3-5 6142803 YP_001745950.1 CDS spoT NC_010498.1 4060424 4062532 D identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4060424..4062532 Escherichia coli SMS-3-5 6145904 YP_001745951.1 CDS trmH NC_010498.1 4062539 4063228 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4062539..4063228 Escherichia coli SMS-3-5 6144135 YP_001745952.1 CDS recG NC_010498.1 4063234 4065315 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4063234..4065315 Escherichia coli SMS-3-5 6146018 YP_001745953.1 CDS gltS NC_010498.1 4065349 4066554 R identified by match to protein family HMM PF03616; match to protein family HMM TIGR00210; sodium/glutamate symporter complement(4065349..4066554) Escherichia coli SMS-3-5 6145498 YP_001745954.1 CDS yicE NC_010498.1 4066834 4068225 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; xanthine permease 4066834..4068225 Escherichia coli SMS-3-5 6146722 YP_001745955.1 CDS EcSMS35_3990 NC_010498.1 4068346 4070055 D identified by match to protein family HMM PF05170; AsmA family protein 4068346..4070055 Escherichia coli SMS-3-5 6146307 YP_001745956.1 CDS EcSMS35_3991 NC_010498.1 4070099 4070779 R identified by similarity to GB:CAH23042.1; match to protein family HMM PF07385; hypothetical protein complement(4070099..4070779) Escherichia coli SMS-3-5 6143269 YP_001745957.1 CDS EcSMS35_3992 NC_010498.1 4070760 4071692 R identified by match to protein family HMM PF00480; ROK family protein complement(4070760..4071692) Escherichia coli SMS-3-5 6144661 YP_001745958.1 CDS EcSMS35_3993 NC_010498.1 4071740 4072600 R identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; hypothetical protein complement(4071740..4072600) Escherichia coli SMS-3-5 6144976 YP_001745959.1 CDS EcSMS35_3994 NC_010498.1 4072681 4073532 R identified by match to protein family HMM PF01116; fructose-bisphosphate aldolase, class II complement(4072681..4073532) Escherichia coli SMS-3-5 6146257 YP_001745960.1 CDS EcSMS35_3996 NC_010498.1 4074992 4075462 R identified by match to protein family HMM PF00359; match to protein family HMM TIGR00848; PTS system, fructose family, IIA component complement(4074992..4075462) Escherichia coli SMS-3-5 6143295 YP_001745961.1 CDS EcSMS35_3997 NC_010498.1 4075489 4077042 R identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; putative PTS regulatory protein complement(4075489..4077042) Escherichia coli SMS-3-5 6142601 YP_001745962.1 CDS EcSMS35_3998 NC_010498.1 4077076 4077189 D identified by Glimmer3; putative; hypothetical protein 4077076..4077189 Escherichia coli SMS-3-5 6144722 YP_001745963.1 CDS yicI NC_010498.1 4077337 4079655 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI complement(4077337..4079655) Escherichia coli SMS-3-5 6144075 YP_001745964.1 CDS EcSMS35_4000 NC_010498.1 4079665 4081047 R may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter complement(4079665..4081047) Escherichia coli SMS-3-5 6144966 YP_001745965.1 CDS EcSMS35_4002 NC_010498.1 4081597 4082760 D identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 4081597..4082760 Escherichia coli SMS-3-5 6143699 YP_001745966.1 CDS EcSMS35_4003 NC_010498.1 4082773 4085493 D identified by Glimmer3; putative; hypothetical protein 4082773..4085493 Escherichia coli SMS-3-5 6146293 YP_001745967.1 CDS EcSMS35_4004 NC_010498.1 4085695 4086267 R identified by match to protein family HMM PF07455; phage polarity suppression protein complement(4085695..4086267) Escherichia coli SMS-3-5 6143751 YP_001745968.1 CDS sid NC_010498.1 4086524 4087258 R identified by similarity to SP:P05461; glycoprotein 3, capsid size determination protein Sid complement(4086524..4087258) Escherichia coli SMS-3-5 6145079 YP_001745969.1 CDS EcSMS35_4006 NC_010498.1 4087811 4088077 D identified by match to protein family HMM PF05930; AlpA family transcriptional regulator 4087811..4088077 Escherichia coli SMS-3-5 6146944 YP_001745970.1 CDS EcSMS35_4007 NC_010498.1 4088260 4088664 D identified by similarity to SP:P05462; phage protein 4088260..4088664 Escherichia coli SMS-3-5 6147171 YP_001745971.1 CDS EcSMS35_4008 NC_010498.1 4088657 4088944 D identified by similarity to SP:P05463; hypothetical protein 4088657..4088944 Escherichia coli SMS-3-5 6143222 YP_001745972.1 CDS EcSMS35_4009 NC_010498.1 4088937 4089392 D identified by similarity to SP:P68663; hypothetical protein 4088937..4089392 Escherichia coli SMS-3-5 6146659 YP_001745973.1 CDS EcSMS35_4010 NC_010498.1 4089528 4089848 D identified by similarity to SP:P68665; hypothetical protein 4089528..4089848 Escherichia coli SMS-3-5 6143441 YP_001745974.1 CDS EcSMS35_4012 NC_010498.1 4089863 4092196 D identified by match to protein family HMM PF01751; match to protein family HMM PF03288; match to protein family HMM PF08273; match to protein family HMM PF08706; match to protein family HMM TIGR01613; D5 family nucleoside triphosphatase 4089863..4092196 Escherichia coli SMS-3-5 6147438 YP_001745975.1 CDS EcSMS35_4011 NC_010498.1 4092151 4092267 R identified by Glimmer3; putative; hypothetical protein complement(4092151..4092267) Escherichia coli SMS-3-5 6144077 YP_001745976.1 CDS EcSMS35_4013 NC_010498.1 4092783 4092929 D identified by Glimmer3; putative; hypothetical protein 4092783..4092929 Escherichia coli SMS-3-5 6144334 YP_001745977.1 CDS setC NC_010498.1 4093311 4094495 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00899; sugar efflux transporter C 4093311..4094495 Escherichia coli SMS-3-5 6142948 YP_001745978.1 CDS EcSMS35_4015 NC_010498.1 4094606 4095529 D identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; carboxylate/amino acid/amine transporter 4094606..4095529 Escherichia coli SMS-3-5 6143293 YP_001745979.1 CDS nlpA NC_010498.1 4095533 4096351 R identified by match to protein family HMM PF03180; match to protein family HMM TIGR00363; cytoplasmic membrane lipoprotein-28 complement(4095533..4096351) Escherichia coli SMS-3-5 6146490 YP_001745980.1 CDS EcSMS35_4017 NC_010498.1 4096560 4096853 D identified by similarity to SP:Q7CPG1; hypothetical protein 4096560..4096853 Escherichia coli SMS-3-5 6144715 YP_001745981.1 CDS EcSMS35_4018 NC_010498.1 4097155 4097652 D identified by match to protein family HMM PF07720; match to protein family HMM TIGR02552; putative type III secretion chaperone SicA 4097155..4097652 Escherichia coli SMS-3-5 6145763 YP_001745982.1 CDS EcSMS35_4019 NC_010498.1 4097662 4097844 D identified by Glimmer3; putative; hypothetical protein 4097662..4097844 Escherichia coli SMS-3-5 6146111 YP_001745983.1 CDS EcSMS35_4020 NC_010498.1 4097900 4099681 D putative type III cell invasion protein SipB 4097900..4099681 Escherichia coli SMS-3-5 6144411 YP_001745984.1 CDS EcSMS35_4021 NC_010498.1 4099694 4100845 D identified by Glimmer3; putative; hypothetical protein 4099694..4100845 Escherichia coli SMS-3-5 6145741 YP_001745985.1 CDS EcSMS35_4022 NC_010498.1 4100889 4102238 D putative type III effector protein SipD 4100889..4102238 Escherichia coli SMS-3-5 6145070 YP_001745986.1 CDS EcSMS35_4023 NC_010498.1 4102441 4104138 D Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system; invasion protein regulator 4102441..4104138 Escherichia coli SMS-3-5 6147192 YP_001745987.1 CDS EcSMS35_4024 NC_010498.1 4104190 4112991 R identified by similarity to SP:P11922; match to protein family HMM PF02369; putative invasin complement(4104190..4112991) Escherichia coli SMS-3-5 6144934 YP_001745988.1 CDS nepI NC_010498.1 4113194 4114378 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(4113194..4114378) Escherichia coli SMS-3-5 6145324 YP_001745989.1 CDS EcSMS35_4026 NC_010498.1 4114612 4114965 D identified by similarity to GB:CAE16839.1; match to protein family HMM PF06296; hypothetical protein 4114612..4114965 Escherichia coli SMS-3-5 6145810 YP_001745990.1 CDS EcSMS35_4027 NC_010498.1 4114949 4115272 D identified by match to protein family HMM PF01381; putative DNA-binding protein 4114949..4115272 Escherichia coli SMS-3-5 6145693 YP_001745991.1 CDS EcSMS35_4028 NC_010498.1 4115388 4115840 R identified by match to protein family HMM PF06711; hypothetical protein complement(4115388..4115840) Escherichia coli SMS-3-5 6146233 YP_001745992.1 CDS EcSMS35_4029 NC_010498.1 4115893 4117239 R identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease family inorganic anion transporter complement(4115893..4117239) Escherichia coli SMS-3-5 6142883 YP_001745993.1 CDS ade NC_010498.1 4117402 4119168 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4117402..4119168 Escherichia coli SMS-3-5 6142999 YP_001745994.1 CDS uhpT NC_010498.1 4119215 4120606 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(4119215..4120606) Escherichia coli SMS-3-5 6144251 YP_001745995.1 CDS uhpC NC_010498.1 4120744 4122063 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(4120744..4122063) Escherichia coli SMS-3-5 6144725 YP_001745996.1 CDS uhpB NC_010498.1 4122073 4123575 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(4122073..4123575) Escherichia coli SMS-3-5 6144031 YP_001745997.1 CDS uhpA NC_010498.1 4123575 4124165 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(4123575..4124165) Escherichia coli SMS-3-5 6143884 YP_001745998.1 CDS EcSMS35_4035 NC_010498.1 4124327 4125829 R identified by Glimmer3; putative; hypothetical protein complement(4124327..4125829) Escherichia coli SMS-3-5 6143515 YP_001745999.1 CDS EcSMS35_4036 NC_010498.1 4126045 4127340 R identified by Glimmer3; putative; hypothetical protein complement(4126045..4127340) Escherichia coli SMS-3-5 6142720 YP_001746000.1 CDS ilvN NC_010498.1 4127603 4127893 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(4127603..4127893) Escherichia coli SMS-3-5 6147093 YP_001746001.1 CDS ilvB NC_010498.1 4127897 4129585 R identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118; acetolactate synthase catalytic subunit complement(4127897..4129585) Escherichia coli SMS-3-5 6143610 YP_001746002.1 CDS emrD NC_010498.1 4130723 4131907 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4130723..4131907 Escherichia coli SMS-3-5 6142808 YP_001746003.1 CDS EcSMS35_4040 NC_010498.1 4131915 4132412 R hypothetical protein complement(4131915..4132412) Escherichia coli SMS-3-5 6147086 YP_001746004.1 CDS EcSMS35_4041 NC_010498.1 4132409 4132771 R hypothetical protein complement(4132409..4132771) Escherichia coli SMS-3-5 6145743 YP_001746005.1 CDS EcSMS35_4042 NC_010498.1 4132761 4133108 R identified by match to protein family HMM PF02656; hypothetical protein complement(4132761..4133108) Escherichia coli SMS-3-5 6145722 YP_001746006.1 CDS EcSMS35_4043 NC_010498.1 4133168 4134661 R identified by match to protein family HMM PF00884; sulfatase complement(4133168..4134661) Escherichia coli SMS-3-5 6145093 YP_001746007.1 CDS EcSMS35_4044 NC_010498.1 4134658 4136373 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK complement(4134658..4136373) Escherichia coli SMS-3-5 6145768 YP_001746008.1 CDS EcSMS35_4046 NC_010498.1 4136540 4137433 D identified by match to protein family HMM PF00165; AraC family transcriptional regulator 4136540..4137433 Escherichia coli SMS-3-5 6144970 YP_001746009.1 CDS glvA NC_010498.1 4137430 4138752 R identified by match to protein family HMM PF02056; maltose-6'-phosphate glucosidase complement(4137430..4138752) Escherichia coli SMS-3-5 6143831 YP_001746010.1 CDS EcSMS35_4047 NC_010498.1 4138752 4140368 R identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00852; match to protein family HMM TIGR02005; PTS system, alpha-glucoside-specific IIBC component complement(4138752..4140368) Escherichia coli SMS-3-5 6144341 YP_001746011.1 CDS EcSMS35_4049 NC_010498.1 4140664 4141380 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 4140664..4141380 Escherichia coli SMS-3-5 6143522 YP_001746012.1 CDS EcSMS35_4048 NC_010498.1 4141377 4143038 R identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625; hypothetical protein complement(4141377..4143038) Escherichia coli SMS-3-5 6146725 YP_001746013.1 CDS EcSMS35_4050 NC_010498.1 4143080 4143229 D identified by Glimmer3; putative; hypothetical protein 4143080..4143229 Escherichia coli SMS-3-5 6142974 YP_001746014.1 CDS ibpB NC_010498.1 4143234 4143662 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(4143234..4143662) Escherichia coli SMS-3-5 6146411 YP_001746015.1 CDS ibpA NC_010498.1 4143774 4144187 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(4143774..4144187) Escherichia coli SMS-3-5 6145144 YP_001746016.1 CDS EcSMS35_4053 NC_010498.1 4144565 4144825 D identified by match to protein family HMM PF07119; hypothetical protein 4144565..4144825 Escherichia coli SMS-3-5 6144486 YP_001746017.1 CDS EcSMS35_4054 NC_010498.1 4144827 4146041 R hypothetical protein complement(4144827..4146041) Escherichia coli SMS-3-5 6145230 YP_001746018.1 CDS EcSMS35_4056 NC_010498.1 4146121 4147206 D FAD/NAD(P)-binding domain; putative oxidoreductase 4146121..4147206 Escherichia coli SMS-3-5 6145930 YP_001746019.1 CDS EcSMS35_4055 NC_010498.1 4147203 4148495 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00881; match to protein family HMM TIGR00893; d-galactonate transporter complement(4147203..4148495) Escherichia coli SMS-3-5 6145193 YP_001746020.1 CDS EcSMS35_4057 NC_010498.1 4148615 4149763 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; galactonate dehydratase complement(4148615..4149763) Escherichia coli SMS-3-5 6146973 YP_001746021.1 CDS EcSMS35_4058 NC_010498.1 4149760 4150377 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(4149760..4150377) Escherichia coli SMS-3-5 6147148 YP_001746022.1 CDS dgoK_1 NC_010498.1 4150361 4151239 R identified by similarity to SP:P31459; match to protein family HMM PF05035; 2-dehydro-3-deoxygalactonokinase complement(4150361..4151239) Escherichia coli SMS-3-5 6145262 YP_001746023.1 CDS dgoR_1 NC_010498.1 4151236 4151925 R identified by similarity to SP:P31460; match to protein family HMM PF00392; match to protein family HMM PF07729; galactonate operon transcriptional repressor complement(4151236..4151925) Escherichia coli SMS-3-5 6146357 YP_001746024.1 CDS EcSMS35_4061 NC_010498.1 4152204 4152860 D hypothetical protein 4152204..4152860 Escherichia coli SMS-3-5 6146874 YP_001746025.1 CDS yidA NC_010498.1 4152904 4153716 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(4152904..4153716) Escherichia coli SMS-3-5 6144509 YP_001746026.1 CDS EcSMS35_4063 NC_010498.1 4153831 4154229 R identified by match to protein family HMM PF06078; hypothetical protein complement(4153831..4154229) Escherichia coli SMS-3-5 6147396 YP_001746027.1 CDS gyrB NC_010498.1 4154373 4156787 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(4154373..4156787) Escherichia coli SMS-3-5 6147196 YP_001746028.1 CDS recF NC_010498.1 4156816 4157889 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(4156816..4157889) Escherichia coli SMS-3-5 6145136 YP_001746029.1 CDS dnaN NC_010498.1 4157889 4158989 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(4157889..4158989) Escherichia coli SMS-3-5 6143496 YP_001746030.1 CDS dnaA NC_010498.1 4158994 4160397 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(4158994..4160397) Escherichia coli SMS-3-5 6146687 YP_001746031.1 CDS EcSMS35_4068 NC_010498.1 4160691 4160891 R identified by Glimmer3; putative; hypothetical protein complement(4160691..4160891) Escherichia coli SMS-3-5 6143876 YP_001746032.1 CDS EcSMS35_4069 NC_010498.1 4160911 4161051 R identified by Glimmer3; putative; hypothetical protein complement(4160911..4161051) Escherichia coli SMS-3-5 6144379 YP_001746033.1 CDS rpmH NC_010498.1 4161004 4161144 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4161004..4161144 Escherichia coli SMS-3-5 6145115 YP_001746034.1 CDS rnpA NC_010498.1 4161161 4161520 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4161161..4161520 Escherichia coli SMS-3-5 6145671 YP_001746035.1 CDS EcSMS35_4072 NC_010498.1 4161744 4163390 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 4161744..4163390 Escherichia coli SMS-3-5 6144017 YP_001746036.1 CDS trmE NC_010498.1 4163496 4164860 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4163496..4164860 Escherichia coli SMS-3-5 6144536 YP_001746037.1 CDS tnaC NC_010498.1 4165102 4165176 D identified by similarity to SP:P0AD89; match to protein family HMM TIGR02616; tryptophanase leader peptide 4165102..4165176 Escherichia coli SMS-3-5 6145291 YP_001746038.1 CDS tnaA NC_010498.1 4165397 4166812 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4165397..4166812 Escherichia coli SMS-3-5 6145087 YP_001746039.1 CDS mdtL NC_010498.1 4168283 4169458 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4168283..4169458 Escherichia coli SMS-3-5 6146957 YP_001746040.1 CDS EcSMS35_4078 NC_010498.1 4169433 4170392 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4169433..4170392 Escherichia coli SMS-3-5 6145099 YP_001746041.1 CDS EcSMS35_4079 NC_010498.1 4170549 4171298 D hypothetical protein 4170549..4171298 Escherichia coli SMS-3-5 6145726 YP_001746042.1 CDS EcSMS35_4080 NC_010498.1 4171320 4171886 D identified by match to protein family HMM PF03358; NADPH-dependent FMN reductase 4171320..4171886 Escherichia coli SMS-3-5 6146428 YP_001746043.1 CDS EcSMS35_4081 NC_010498.1 4171940 4173277 R identified by match to protein family HMM PF00860; sulfate permease family inorganic anion transporter complement(4171940..4173277) Escherichia coli SMS-3-5 6147165 YP_001746044.1 CDS EcSMS35_4082 NC_010498.1 4173444 4174109 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4173444..4174109 Escherichia coli SMS-3-5 6142927 YP_001746045.1 CDS EcSMS35_4083 NC_010498.1 4174246 4176654 R identified by similarity to GB:ABB63945.1; hypothetical protein complement(4174246..4176654) Escherichia coli SMS-3-5 6143478 YP_001746046.1 CDS EcSMS35_4084 NC_010498.1 4176786 4176899 R identified by Glimmer3; putative; hypothetical protein complement(4176786..4176899) Escherichia coli SMS-3-5 6146427 YP_001746047.1 CDS EcSMS35_4085 NC_010498.1 4176955 4178142 D identified by similarity to GB:ABG83000.1; hypothetical protein 4176955..4178142 Escherichia coli SMS-3-5 6147164 YP_001746048.1 CDS EcSMS35_4086 NC_010498.1 4178612 4181101 R identified by similarity to GB:ABB63945.1; hypothetical protein complement(4178612..4181101) Escherichia coli SMS-3-5 6145312 YP_001746049.1 CDS EcSMS35_4087 NC_010498.1 4181261 4181374 R identified by Glimmer3; putative; hypothetical protein complement(4181261..4181374) Escherichia coli SMS-3-5 6145816 YP_001746050.1 CDS phoU NC_010498.1 4181528 4182253 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(4181528..4182253) Escherichia coli SMS-3-5 6146985 YP_001746051.1 CDS pstB NC_010498.1 4182268 4183041 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(4182268..4183041) Escherichia coli SMS-3-5 6147450 YP_001746052.1 CDS pstA NC_010498.1 4183131 4184021 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(4183131..4184021) Escherichia coli SMS-3-5 6143072 YP_001746053.1 CDS pstC NC_010498.1 4184021 4184980 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(4184021..4184980) Escherichia coli SMS-3-5 6143745 YP_001746054.1 CDS pstS NC_010498.1 4185067 4186107 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR00975; phosphate ABC transporter periplasmic substrate-binding protein PstS complement(4185067..4186107) Escherichia coli SMS-3-5 6144392 YP_001746055.1 CDS lpfD NC_010498.1 4186355 4187425 R identified by similarity to GB:AAL18164.1; long polar fimbrial operon protein LpfD complement(4186355..4187425) Escherichia coli SMS-3-5 6145107 YP_001746056.1 CDS lpfC NC_010498.1 4187436 4189958 R identified by similarity to GB:AAL18163.1; match to protein family HMM PF00577; long polar fimbrial operon protein LpfC complement(4187436..4189958) Escherichia coli SMS-3-5 6142994 YP_001746057.1 CDS lpfB NC_010498.1 4189983 4190714 R identified by similarity to GB:AAL18162.1; match to protein family HMM PF00345; match to protein family HMM PF02753; long polar fimbrial operon protein LpfB complement(4189983..4190714) Escherichia coli SMS-3-5 6143558 YP_001746058.1 CDS lpfA NC_010498.1 4190762 4191334 R identified by match to protein family HMM PF00419; long polar fimbrial operon protein LpfA complement(4190762..4191334) Escherichia coli SMS-3-5 6145389 YP_001746059.1 CDS glmS NC_010498.1 4191642 4193471 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(4191642..4193471) Escherichia coli SMS-3-5 6144698 YP_001746060.1 CDS glmU NC_010498.1 4193633 4195003 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(4193633..4195003) Escherichia coli SMS-3-5 6145586 YP_001746061.1 CDS atpC NC_010498.1 4195352 4195771 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(4195352..4195771) Escherichia coli SMS-3-5 6143912 YP_001746062.1 CDS atpD NC_010498.1 4195792 4197174 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(4195792..4197174) Escherichia coli SMS-3-5 6147121 YP_001746063.1 CDS atpG NC_010498.1 4197201 4198064 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(4197201..4198064) Escherichia coli SMS-3-5 6145373 YP_001746064.1 CDS atpA NC_010498.1 4198115 4199656 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(4198115..4199656) Escherichia coli SMS-3-5 6143530 YP_001746065.1 CDS atpH NC_010498.1 4199669 4200202 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(4199669..4200202) Escherichia coli SMS-3-5 6146698 YP_001746066.1 CDS atpF NC_010498.1 4200217 4200687 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(4200217..4200687) Escherichia coli SMS-3-5 6144071 YP_001746067.1 CDS atpE NC_010498.1 4200749 4200988 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(4200749..4200988) Escherichia coli SMS-3-5 6144700 YP_001746068.1 CDS atpB NC_010498.1 4201035 4201850 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(4201035..4201850) Escherichia coli SMS-3-5 6145457 YP_001746069.1 CDS atpI NC_010498.1 4201859 4202077 R identified by match to protein family HMM PF03899; ATP synthase F0, I subunit complement(4201859..4202077) Escherichia coli SMS-3-5 6146095 YP_001746070.1 CDS gidB NC_010498.1 4202856 4203479 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4202856..4203479) Escherichia coli SMS-3-5 6143014 YP_001746071.1 CDS gidA NC_010498.1 4203543 4205432 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA complement(4203543..4205432) Escherichia coli SMS-3-5 6146368 YP_001746072.1 CDS mioC NC_010498.1 4205811 4206254 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(4205811..4206254) Escherichia coli SMS-3-5 6144762 YP_001746073.1 CDS asnC NC_010498.1 4206344 4206802 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(4206344..4206802) Escherichia coli SMS-3-5 6147436 YP_001746074.1 CDS asnA NC_010498.1 4206954 4207946 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4206954..4207946 Escherichia coli SMS-3-5 6144321 YP_001746075.1 CDS yieM NC_010498.1 4207951 4209402 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(4207951..4209402) Escherichia coli SMS-3-5 6142921 YP_001746076.1 CDS EcSMS35_4114 NC_010498.1 4209396 4210892 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(4209396..4210892) Escherichia coli SMS-3-5 6143270 YP_001746077.1 CDS trkD NC_010498.1 4211115 4212983 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4211115..4212983 Escherichia coli SMS-3-5 6143844 YP_001746078.1 CDS rbsD NC_010498.1 4213138 4213569 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4213138..4213569 Escherichia coli SMS-3-5 6147203 YP_001746079.1 CDS rbsA NC_010498.1 4213577 4215082 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4213577..4215082 Escherichia coli SMS-3-5 6147412 YP_001746080.1 CDS rbsC NC_010498.1 4215087 4216052 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4215087..4216052 Escherichia coli SMS-3-5 6146643 YP_001746081.1 CDS rbsB NC_010498.1 4216077 4216967 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4216077..4216967 Escherichia coli SMS-3-5 6147324 YP_001746082.1 CDS rbsK NC_010498.1 4217078 4218022 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4217078..4218022 Escherichia coli SMS-3-5 6145739 YP_001746083.1 CDS rbsR NC_010498.1 4218026 4219018 D DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4218026..4219018 Escherichia coli SMS-3-5 6146143 YP_001746084.1 CDS EcSMS35_4121 NC_010498.1 4218984 4220411 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; DHA2 family drug:H+ antiporter-1 complement(4218984..4220411) Escherichia coli SMS-3-5 6144620 YP_001746085.1 CDS EcSMS35_4123 NC_010498.1 4220434 4221126 R identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator complement(4220434..4221126) Escherichia coli SMS-3-5 6143899 YP_001746086.1 CDS hdfR NC_010498.1 4226916 4227755 R Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR complement(4226916..4227755) Escherichia coli SMS-3-5 6143655 YP_001746087.1 CDS EcSMS35_4132 NC_010498.1 4227874 4228212 D identified by match to protein family HMM PF04219; hypothetical protein 4227874..4228212 Escherichia coli SMS-3-5 6147215 YP_001746088.1 CDS EcSMS35_4133 NC_010498.1 4228237 4229757 R among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease complement(4228237..4229757) Escherichia coli SMS-3-5 6146654 YP_001746089.1 CDS ilvG NC_010498.1 4230348 4231994 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4230348..4231994 Escherichia coli SMS-3-5 6144247 YP_001746090.1 CDS ilvM NC_010498.1 4231991 4232254 D acetolactate synthase 2 regulatory subunit 4231991..4232254 Escherichia coli SMS-3-5 6143333 YP_001746091.1 CDS ilvE NC_010498.1 4232274 4233203 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4232274..4233203 Escherichia coli SMS-3-5 6145304 YP_001746092.1 CDS ilvD NC_010498.1 4233268 4235118 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4233268..4235118 Escherichia coli SMS-3-5 6144498 YP_001746093.1 CDS ilvA NC_010498.1 4235118 4236665 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4235118..4236665 Escherichia coli SMS-3-5 6146922 YP_001746094.1 CDS ilvY NC_010498.1 4236662 4237552 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(4236662..4237552) Escherichia coli SMS-3-5 6144716 YP_001746095.1 CDS ilvC NC_010498.1 4237702 4239177 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4237702..4239177 Escherichia coli SMS-3-5 6146382 YP_001746096.1 CDS ppiC NC_010498.1 4239223 4239504 R identified by match to protein family HMM PF00639; peptidyl-prolyl cis-trans isomerase C complement(4239223..4239504) Escherichia coli SMS-3-5 6143201 YP_001746097.1 CDS rep NC_010498.1 4240324 4242345 D single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4240324..4242345 Escherichia coli SMS-3-5 6146748 YP_001746098.1 CDS gppA NC_010498.1 4242392 4243876 R catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase complement(4242392..4243876) Escherichia coli SMS-3-5 6145004 YP_001746099.1 CDS rhlB NC_010498.1 4244012 4245277 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(4244012..4245277) Escherichia coli SMS-3-5 6146084 YP_001746100.1 CDS trxA NC_010498.1 4245408 4245737 D identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 4245408..4245737 Escherichia coli SMS-3-5 6144072 YP_001746101.1 CDS rho NC_010498.1 4246064 4247323 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4246064..4247323 Escherichia coli SMS-3-5 6144642 YP_001746102.1 CDS EcSMS35_4147 NC_010498.1 4247333 4247551 D identified by Glimmer3; putative; hypothetical protein 4247333..4247551 Escherichia coli SMS-3-5 6142965 YP_001746103.1 CDS wecA NC_010498.1 4247563 4248666 D identified by match to protein family HMM PF00953; match to protein family HMM TIGR02380; undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase 4247563..4248666 Escherichia coli SMS-3-5 6143502 YP_001746104.1 CDS EcSMS35_4149 NC_010498.1 4248678 4249724 D Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4248678..4249724 Escherichia coli SMS-3-5 6146238 YP_001746105.1 CDS EcSMS35_4150 NC_010498.1 4249780 4250910 D identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 4249780..4250910 Escherichia coli SMS-3-5 6147133 YP_001746106.1 CDS wecC NC_010498.1 4250907 4252169 D catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4250907..4252169 Escherichia coli SMS-3-5 6146455 YP_001746107.1 CDS rfbB2 NC_010498.1 4252169 4253236 D identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase 4252169..4253236 Escherichia coli SMS-3-5 6143553 YP_001746108.1 CDS rfbA NC_010498.1 4253255 4254136 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 4253255..4254136 Escherichia coli SMS-3-5 6142900 YP_001746109.1 CDS wecD NC_010498.1 4254114 4254788 D identified by match to protein family HMM PF00583; match to protein family HMM TIGR02382; TDP-fucosamine acetyltransferase 4254114..4254788 Escherichia coli SMS-3-5 6144215 YP_001746110.1 CDS wecE NC_010498.1 4254793 4255923 D catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4254793..4255923 Escherichia coli SMS-3-5 6145995 YP_001746111.1 CDS EcSMS35_4156 NC_010498.1 4255925 4257175 D identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein 4255925..4257175 Escherichia coli SMS-3-5 6145786 YP_001746112.1 CDS wecF NC_010498.1 4257172 4258251 D catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4257172..4258251 Escherichia coli SMS-3-5 6144964 YP_001746113.1 CDS wzyE NC_010498.1 4258248 4259600 D enterobacterial common antigen polymerase; putative common antigen polymerase 4258248..4259600 Escherichia coli SMS-3-5 6146286 YP_001746114.1 CDS EcSMS35_4159 NC_010498.1 4259603 4260343 D identified by match to protein family HMM PF03808; match to protein family HMM TIGR00696; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 4259603..4260343 Escherichia coli SMS-3-5 6143244 YP_001746115.1 CDS EcSMS35_4160 NC_010498.1 4260534 4261919 D uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 4260534..4261919 Escherichia coli SMS-3-5 6142956 YP_001746116.1 CDS aslB NC_010498.1 4262605 4263840 D identified by match to protein family HMM PF04055; arylsulfatase-activating protein AslB 4262605..4263840 Escherichia coli SMS-3-5 6143689 YP_001746117.1 CDS aslA NC_010498.1 4263998 4265653 R identified by similarity to SP:P25549; match to protein family HMM PF00884; arylsulfatase complement(4263998..4265653) Escherichia coli SMS-3-5 6146022 YP_001746118.1 CDS hemY NC_010498.1 4266317 4267513 R identified by match to protein family HMM PF07219; match to protein family HMM PF07719; match to protein family HMM TIGR00540; putative protoheme IX biogenesis protein complement(4266317..4267513) Escherichia coli SMS-3-5 6145480 YP_001746119.1 CDS EcSMS35_4168 NC_010498.1 4267516 4268709 R identified by match to protein family HMM PF04375; putative uroporphyrinogen III C-methyltransferase complement(4267516..4268709) Escherichia coli SMS-3-5 6146761 YP_001746120.1 CDS hemD NC_010498.1 4268731 4269471 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase complement(4268731..4269471) Escherichia coli SMS-3-5 6146217 YP_001746121.1 CDS hemC NC_010498.1 4269468 4270424 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(4269468..4270424) Escherichia coli SMS-3-5 6142678 YP_001746122.1 CDS cyaA NC_010498.1 4270796 4273342 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4270796..4273342 Escherichia coli SMS-3-5 6144359 YP_001746123.1 CDS cyaY NC_010498.1 4273382 4273702 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(4273382..4273702) Escherichia coli SMS-3-5 6143770 YP_001746124.1 CDS EcSMS35_4173 NC_010498.1 4273750 4274013 R putative lipoprotein complement(4273750..4274013) Escherichia coli SMS-3-5 6145761 YP_001746125.1 CDS EcSMS35_4174 NC_010498.1 4274172 4274375 D putative lipoprotein 4274172..4274375 Escherichia coli SMS-3-5 6146861 YP_001746126.1 CDS dapF NC_010498.1 4274412 4275236 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4274412..4275236 Escherichia coli SMS-3-5 6146170 YP_001746127.1 CDS EcSMS35_4176 NC_010498.1 4275233 4275940 D identified by match to protein family HMM PF04340; hypothetical protein 4275233..4275940 Escherichia coli SMS-3-5 6143231 YP_001746128.1 CDS xerC NC_010498.1 4275937 4276833 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4275937..4276833 Escherichia coli SMS-3-5 6147476 YP_001746129.1 CDS EcSMS35_4178 NC_010498.1 4276833 4277549 D YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4276833..4277549 Escherichia coli SMS-3-5 6142893 YP_001746130.1 CDS uvrD NC_010498.1 4277633 4279795 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4277633..4279795 Escherichia coli SMS-3-5 6144651 YP_001746131.1 CDS EcSMS35_4180 NC_010498.1 4279850 4280752 R identified by match to protein family HMM PF01887; hypothetical protein complement(4279850..4280752) Escherichia coli SMS-3-5 6143739 YP_001746132.1 CDS EcSMS35_4181 NC_010498.1 4280835 4281599 R hypothetical protein complement(4280835..4281599) Escherichia coli SMS-3-5 6145574 YP_001746133.1 CDS EcSMS35_4182 NC_010498.1 4281612 4281725 D identified by Glimmer3; putative; hypothetical protein 4281612..4281725 Escherichia coli SMS-3-5 6145014 YP_001746134.1 CDS corA NC_010498.1 4281969 4282919 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4281969..4282919 Escherichia coli SMS-3-5 6146872 YP_001746135.1 CDS EcSMS35_4184 NC_010498.1 4282955 4283452 R identified by match to protein family HMM PF06092; hypothetical protein complement(4282955..4283452) Escherichia coli SMS-3-5 6144364 YP_001746136.1 CDS EcSMS35_4185 NC_010498.1 4283449 4284297 R identified by match to protein family HMM TIGR03034; hypothetical protein complement(4283449..4284297) Escherichia coli SMS-3-5 6143874 YP_001746137.1 CDS rarD NC_010498.1 4284607 4285497 R identified by match to protein family HMM PF00892; match to protein family HMM TIGR00688; RarD protein complement(4284607..4285497) Escherichia coli SMS-3-5 6143328 YP_001746138.1 CDS EcSMS35_4187 NC_010498.1 4285549 4286016 R identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein complement(4285549..4286016) Escherichia coli SMS-3-5 6142783 YP_001746139.1 CDS pldA NC_010498.1 4286181 4287050 D catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4286181..4287050 Escherichia coli SMS-3-5 6143900 YP_001746140.1 CDS recQ NC_010498.1 4287169 4289004 D functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4287169..4289004 Escherichia coli SMS-3-5 6145557 YP_001746141.1 CDS rhtC NC_010498.1 4289068 4289688 D identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; threonine efflux system 4289068..4289688 Escherichia coli SMS-3-5 6145038 YP_001746142.1 CDS rhtB NC_010498.1 4289750 4290370 R identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; homoserine/homoserine lactone efflux protein complement(4289750..4290370) Escherichia coli SMS-3-5 6147230 YP_001746143.1 CDS pldB NC_010498.1 4290481 4291503 D lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4290481..4291503 Escherichia coli SMS-3-5 6146621 YP_001746144.1 CDS EcSMS35_4193 NC_010498.1 4291511 4292311 D purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 4291511..4292311 Escherichia coli SMS-3-5 6143443 YP_001746145.1 CDS EcSMS35_4194 NC_010498.1 4292387 4293286 D identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; 10 TMS drug/metabolite exporter (DME) family protein 4292387..4293286 Escherichia coli SMS-3-5 6147246 YP_001746146.1 CDS metE NC_010498.1 4294245 4296506 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4294245..4296506 Escherichia coli SMS-3-5 6146586 YP_001746147.1 CDS EcSMS35_4196 NC_010498.1 4296600 4297496 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(4296600..4297496) Escherichia coli SMS-3-5 6143210 YP_001746148.1 CDS EcSMS35_4197 NC_010498.1 4297574 4298797 R identified by match to protein family HMM PF02133; cytosine/purines/uracil/thiamine/allantoin family permease complement(4297574..4298797) Escherichia coli SMS-3-5 6142696 YP_001746149.1 CDS EcSMS35_4198 NC_010498.1 4298823 4299212 R identified by similarity to RF:NP_756622.1; hypothetical protein complement(4298823..4299212) Escherichia coli SMS-3-5 6144363 YP_001746150.1 CDS EcSMS35_4199 NC_010498.1 4299229 4300185 R catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(4299229..4300185) Escherichia coli SMS-3-5 6144006 YP_001746151.1 CDS EcSMS35_4200 NC_010498.1 4300178 4301602 R identified by match to protein family HMM PF06545; hypothetical protein complement(4300178..4301602) Escherichia coli SMS-3-5 6145395 YP_001746152.1 CDS EcSMS35_4201 NC_010498.1 4301599 4303158 R identified by match to protein family HMM PF06263; acyl-CoA synthetase complement(4301599..4303158) Escherichia coli SMS-3-5 6144975 YP_001746153.1 CDS EcSMS35_4202 NC_010498.1 4303253 4304113 R identified by similarity to GB:AAZ87092.1; hypothetical protein complement(4303253..4304113) Escherichia coli SMS-3-5 6146550 YP_001746154.1 CDS EcSMS35_4203 NC_010498.1 4304119 4304787 R identified by match to protein family HMM PF00857; isochorismatase family protein complement(4304119..4304787) Escherichia coli SMS-3-5 6143578 YP_001746155.1 CDS EcSMS35_4204 NC_010498.1 4304805 4304918 D identified by Glimmer3; putative; hypothetical protein 4304805..4304918 Escherichia coli SMS-3-5 6145101 YP_001746156.1 CDS EcSMS35_4205 NC_010498.1 4304897 4305013 D identified by Glimmer3; putative; hypothetical protein 4304897..4305013 Escherichia coli SMS-3-5 6145740 YP_001746157.1 CDS EcSMS35_4206 NC_010498.1 4305044 4305853 R identified by match to protein family HMM PF01738; dienelactone hydrolase family protein complement(4305044..4305853) Escherichia coli SMS-3-5 6143836 YP_001746158.1 CDS EcSMS35_4207 NC_010498.1 4305985 4306101 R identified by Glimmer3; putative; hypothetical protein complement(4305985..4306101) Escherichia coli SMS-3-5 6144371 YP_001746159.1 CDS udp NC_010498.1 4306115 4306879 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4306115..4306879 Escherichia coli SMS-3-5 6147358 YP_001746160.1 CDS EcSMS35_4209 NC_010498.1 4306913 4308403 R identified by match to protein family HMM PF01970; integral membrane protein complement(4306913..4308403) Escherichia coli SMS-3-5 6143080 YP_001746161.1 CDS EcSMS35_4210 NC_010498.1 4308416 4308922 R identified by Glimmer3; putative; hypothetical protein complement(4308416..4308922) Escherichia coli SMS-3-5 6147012 YP_001746162.1 CDS EcSMS35_4211 NC_010498.1 4308939 4309913 R identified by match to protein family HMM PF03401; periplasmic binding protein complement(4308939..4309913) Escherichia coli SMS-3-5 6144949 YP_001746163.1 CDS EcSMS35_4212 NC_010498.1 4309938 4310567 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(4309938..4310567) Escherichia coli SMS-3-5 6145236 YP_001746164.1 CDS EcSMS35_4213 NC_010498.1 4310557 4311561 R identified by similarity to SP:P31459; match to protein family HMM PF05035; 2-dehydro-3-deoxygalactonokinase complement(4310557..4311561) Escherichia coli SMS-3-5 6143996 YP_001746165.1 CDS EcSMS35_4214 NC_010498.1 4311585 4312439 R identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator complement(4311585..4312439) Escherichia coli SMS-3-5 6143009 YP_001746166.1 CDS rmuC NC_010498.1 4312569 4313996 D YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4312569..4313996 Escherichia coli SMS-3-5 6147404 YP_001746167.1 CDS ubiE NC_010498.1 4314091 4314846 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4314091..4314846 Escherichia coli SMS-3-5 6146919 YP_001746168.1 CDS EcSMS35_4217 NC_010498.1 4314860 4315465 D identified by match to protein family HMM PF06843; hypothetical protein 4314860..4315465 Escherichia coli SMS-3-5 6146280 YP_001746169.1 CDS ubiB NC_010498.1 4315462 4317102 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 4315462..4317102 Escherichia coli SMS-3-5 6143929 YP_001746170.1 CDS tatA NC_010498.1 4317181 4317450 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4317181..4317450 Escherichia coli SMS-3-5 6145920 YP_001746171.1 CDS tatB NC_010498.1 4317454 4317969 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4317454..4317969 Escherichia coli SMS-3-5 6142806 YP_001746172.1 CDS tatC NC_010498.1 4317972 4318748 D with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4317972..4318748 Escherichia coli SMS-3-5 6144785 YP_001746173.1 CDS tatD NC_010498.1 4318790 4319572 D magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4318790..4319572 Escherichia coli SMS-3-5 6147310 YP_001746174.1 CDS rfaH NC_010498.1 4319569 4320057 R identified by match to protein family HMM PF02357; match to protein family HMM TIGR01955; transcriptional activator RfaH complement(4319569..4320057) Escherichia coli SMS-3-5 6143458 YP_001746175.1 CDS ubiD NC_010498.1 4320224 4321717 D catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 4320224..4321717 Escherichia coli SMS-3-5 6146624 YP_001746176.1 CDS fre NC_010498.1 4321763 4322464 D NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4321763..4322464 Escherichia coli SMS-3-5 6146968 YP_001746177.1 CDS fadA NC_010498.1 4322655 4323818 R FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase complement(4322655..4323818) Escherichia coli SMS-3-5 6147277 YP_001746178.1 CDS fadB NC_010498.1 4323828 4326017 R includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha complement(4323828..4326017) Escherichia coli SMS-3-5 6146603 YP_001746179.1 CDS pepQ NC_010498.1 4326207 4327538 D catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4326207..4327538 Escherichia coli SMS-3-5 6143415 YP_001746180.1 CDS EcSMS35_4229 NC_010498.1 4327538 4328152 D yigZ; identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 4327538..4328152 Escherichia coli SMS-3-5 6142690 YP_001746181.1 CDS trkH NC_010498.1 4328191 4329642 D identified by match to protein family HMM PF02386; match to protein family HMM TIGR00933; potassium transporter 4328191..4329642 Escherichia coli SMS-3-5 6145261 YP_001746182.1 CDS hemG NC_010498.1 4329654 4330199 D catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4329654..4330199 Escherichia coli SMS-3-5 6144005 YP_001746183.1 CDS mobB NC_010498.1 4335689 4336216 R in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B complement(4335689..4336216) Escherichia coli SMS-3-5 6143713 YP_001746184.1 CDS mobA NC_010498.1 4336198 4336782 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(4336198..4336782) Escherichia coli SMS-3-5 6144528 YP_001746185.1 CDS EcSMS35_4239 NC_010498.1 4336852 4337121 D identified by match to protein family HMM PF06288; hypothetical protein 4336852..4337121 Escherichia coli SMS-3-5 6142653 YP_001746186.1 CDS EcSMS35_4240 NC_010498.1 4337198 4338184 D catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4337198..4338184 Escherichia coli SMS-3-5 6145834 YP_001746187.1 CDS dsbA NC_010498.1 4338201 4338827 D identified by similarity to SP:P0AEG4; match to protein family HMM PF01323; periplasmic protein disulfide isomerase I 4338201..4338827 Escherichia coli SMS-3-5 6144184 YP_001746188.1 CDS EcSMS35_4242 NC_010498.1 4338852 4338992 D identified by Glimmer3; putative; hypothetical protein 4338852..4338992 Escherichia coli SMS-3-5 6145391 YP_001746189.1 CDS EcSMS35_4244 NC_010498.1 4340452 4341408 R identified by match to protein family HMM PF01553; putative acyltransferase complement(4340452..4341408) Escherichia coli SMS-3-5 6146290 YP_001746190.1 CDS EcSMS35_4245 NC_010498.1 4341504 4341689 R identified by Glimmer3; putative; hypothetical protein complement(4341504..4341689) Escherichia coli SMS-3-5 6144027 YP_001746191.1 CDS polA NC_010498.1 4341748 4344534 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4341748..4344534 Escherichia coli SMS-3-5 6144695 YP_001746192.1 CDS EcSMS35_4247 NC_010498.1 4344753 4344902 R identified by Glimmer3; putative; hypothetical protein complement(4344753..4344902) Escherichia coli SMS-3-5 6142787 YP_001746193.1 CDS engB NC_010498.1 4344916 4345548 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(4344916..4345548) Escherichia coli SMS-3-5 6144823 YP_001746194.1 CDS EcSMS35_4249 NC_010498.1 4346130 4346639 D identified by match to protein family HMM PF04220; hypothetical protein 4346130..4346639 Escherichia coli SMS-3-5 6142976 YP_001746195.1 CDS EcSMS35_4250 NC_010498.1 4346713 4346829 R identified by Glimmer3; putative; hypothetical protein complement(4346713..4346829) Escherichia coli SMS-3-5 6144663 YP_001746196.1 CDS hemN NC_010498.1 4346828 4348201 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4346828..4348201 Escherichia coli SMS-3-5 6143182 YP_001746197.1 CDS EcSMS35_4252 NC_010498.1 4348294 4348407 R identified by Glimmer3; putative; hypothetical protein complement(4348294..4348407) Escherichia coli SMS-3-5 6142616 YP_001746198.1 CDS glnG NC_010498.1 4348613 4350031 R response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) complement(4348613..4350031) Escherichia coli SMS-3-5 6146733 YP_001746199.1 CDS glnL NC_010498.1 4350034 4351083 R sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) complement(4350034..4351083) Escherichia coli SMS-3-5 6146202 YP_001746200.1 CDS glnA NC_010498.1 4351257 4352666 R forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase complement(4351257..4352666) Escherichia coli SMS-3-5 6146070 YP_001746201.1 CDS typA NC_010498.1 4353039 4354862 D identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein 4353039..4354862 Escherichia coli SMS-3-5 6145025 YP_001746202.1 CDS EcSMS35_4257 NC_010498.1 4355079 4355789 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 4355079..4355789 Escherichia coli SMS-3-5 6142931 YP_001746203.1 CDS EcSMS35_4258 NC_010498.1 4355899 4356777 D identified by match to protein family HMM PF01261; AP endonuclease 4355899..4356777 Escherichia coli SMS-3-5 6147333 YP_001746204.1 CDS EcSMS35_4259 NC_010498.1 4356879 4358144 D identified by match to protein family HMM PF07690; major facilitator transporter 4356879..4358144 Escherichia coli SMS-3-5 6146835 YP_001746205.1 CDS ompL NC_010498.1 4358236 4358928 R porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L complement(4358236..4358928) Escherichia coli SMS-3-5 6146333 YP_001746206.1 CDS EcSMS35_4261 NC_010498.1 4358995 4360398 R identified by match to protein family HMM TIGR00792; sugar (glycoside-Pentoside-hexuronide) transporter family protein complement(4358995..4360398) Escherichia coli SMS-3-5 6145764 YP_001746207.1 CDS EcSMS35_4262 NC_010498.1 4360441 4361826 R identified by match to protein family HMM TIGR00792; sugar transporter family protein complement(4360441..4361826) Escherichia coli SMS-3-5 6146474 YP_001746208.1 CDS EcSMS35_4263 NC_010498.1 4361872 4363908 R identified by match to protein family HMM PF01055; alpha-glucosidase complement(4361872..4363908) Escherichia coli SMS-3-5 6144713 YP_001746209.1 CDS EcSMS35_4264 NC_010498.1 4364106 4365005 R identified by match to protein family HMM PF01263; aldose-1-epimerase family protein complement(4364106..4365005) Escherichia coli SMS-3-5 6144104 YP_001746210.1 CDS EcSMS35_4265 NC_010498.1 4365124 4366365 R identified by match to protein family HMM PF07221; N-acylglucosamine 2-epimerase complement(4365124..4366365) Escherichia coli SMS-3-5 6143294 YP_001746211.1 CDS EcSMS35_4266 NC_010498.1 4366381 4367259 R identified by match to protein family HMM PF01791; deoxyribose-phosphate aldolase complement(4366381..4367259) Escherichia coli SMS-3-5 6147517 YP_001746212.1 CDS EcSMS35_4267 NC_010498.1 4367283 4368179 R identified by match to protein family HMM PF03446; 3-hydroxyisobutyrate dehydrogenase complement(4367283..4368179) Escherichia coli SMS-3-5 6144081 YP_001746213.1 CDS EcSMS35_4268 NC_010498.1 4368347 4369243 D identified by match to protein family HMM PF00294; PfkB family kinase 4368347..4369243 Escherichia coli SMS-3-5 6144712 YP_001746214.1 CDS EcSMS35_4269 NC_010498.1 4369277 4370062 D identified by match to protein family HMM PF00455; match to protein family HMM PF01022; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator 4369277..4370062 Escherichia coli SMS-3-5 6147530 YP_001746215.1 CDS yihX NC_010498.1 4370161 4370760 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; phosphatase 4370161..4370760 Escherichia coli SMS-3-5 6143283 YP_001746216.1 CDS rbn NC_010498.1 4370754 4371626 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4370754..4371626 Escherichia coli SMS-3-5 6146195 YP_001746217.1 CDS dtd NC_010498.1 4371623 4372060 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4371623..4372060 Escherichia coli SMS-3-5 6146857 YP_001746218.1 CDS EcSMS35_4273 NC_010498.1 4372105 4373046 D identified by match to protein family HMM PF00583; match to protein family HMM TIGR02447; acetyltransferase 4372105..4373046 Escherichia coli SMS-3-5 6144309 YP_001746219.1 CDS EcSMS35_4274 NC_010498.1 4373462 4375276 D identified by Glimmer3; putative; hypothetical protein 4373462..4375276 Escherichia coli SMS-3-5 6144827 YP_001746220.1 CDS EcSMS35_4275 NC_010498.1 4375972 4376190 D identified by match to protein family HMM PF01402; CopG family protein 4375972..4376190 Escherichia coli SMS-3-5 6145362 YP_001746221.1 CDS EcSMS35_4276 NC_010498.1 4376433 4376651 D hypothetical protein 4376433..4376651 Escherichia coli SMS-3-5 6145849 YP_001746222.1 CDS fdhE NC_010498.1 4376980 4377909 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(4376980..4377909) Escherichia coli SMS-3-5 6145354 YP_001746223.1 CDS fdoI NC_010498.1 4377906 4378541 R cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma complement(4377906..4378541) Escherichia coli SMS-3-5 6145852 YP_001746224.1 CDS fdoH NC_010498.1 4378538 4379440 R identified by match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582; formate dehydrogenase-O, iron-sulfur subunit complement(4378538..4379440) Escherichia coli SMS-3-5 6143568 YP_001746225.1 CDS fdoG NC_010498.1 4379453 4382503 R Selenoprotein. identified by similarity to SP:P32176; match to protein family HMM PF04879; match to protein family HMM TIGR01409; formate dehydrogenase-O, major subunit, selenocysteine-containing complement(4379453..4382503) Escherichia coli SMS-3-5 6144178 YP_001746226.1 CDS EcSMS35_4281 NC_010498.1 4382507 4382761 D identified by Glimmer3; putative; hypothetical protein 4382507..4382761 Escherichia coli SMS-3-5 6147346 YP_001746227.1 CDS fdhD NC_010498.1 4382730 4383533 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4382730..4383533 Escherichia coli SMS-3-5 6145826 YP_001746228.1 CDS EcSMS35_4283 NC_010498.1 4383727 4383852 R identified by Glimmer3; putative; hypothetical protein complement(4383727..4383852) Escherichia coli SMS-3-5 6146551 YP_001746229.1 CDS EcSMS35_4284 NC_010498.1 4383843 4385678 D identified by similarity to GB:CAJ22947.1; hypothetical protein 4383843..4385678 Escherichia coli SMS-3-5 6145104 YP_001746230.1 CDS EcSMS35_4285 NC_010498.1 4385680 4387986 D identified by similarity to GB:ABJ10234.1; hypothetical protein 4385680..4387986 Escherichia coli SMS-3-5 6145758 YP_001746231.1 CDS EcSMS35_4286 NC_010498.1 4388181 4389236 D putative lipoprotein 4388181..4389236 Escherichia coli SMS-3-5 6142909 YP_001746232.1 CDS EcSMS35_4287 NC_010498.1 4389292 4391040 R putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; putative frv operon regulatory protein complement(4389292..4391040) Escherichia coli SMS-3-5 6147311 YP_001746233.1 CDS EcSMS35_4288 NC_010498.1 4391040 4392110 R with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; putative fructose-specific phosphotransferase system protein FrvX complement(4391040..4392110) Escherichia coli SMS-3-5 6147274 YP_001746234.1 CDS EcSMS35_4289 NC_010498.1 4392100 4393557 R identified by match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR01427; putative PTS system transporter subunits IIBC complement(4392100..4393557) Escherichia coli SMS-3-5 6142723 YP_001746235.1 CDS EcSMS35_4290 NC_010498.1 4393562 4394008 R with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; putative fructose-like phosphotransferase system subunit EIIA complement(4393562..4394008) Escherichia coli SMS-3-5 6145882 YP_001746236.1 CDS rafY2 NC_010498.1 4394485 4395879 D identified by similarity to GB:AAB71432.1; glycoporin RafY 4394485..4395879 Escherichia coli SMS-3-5 6146426 YP_001746237.1 CDS rhaU NC_010498.1 4395920 4396234 R identified by match to protein family HMM PF05336; match to protein family HMM TIGR02625; L-rhamnose 1-epimerase complement(4395920..4396234) Escherichia coli SMS-3-5 6145191 YP_001746238.1 CDS rhaD NC_010498.1 4396244 4397068 R identified by match to protein family HMM PF00596; match to protein family HMM TIGR02624; rhamnulose-1-phosphate aldolase complement(4396244..4397068) Escherichia coli SMS-3-5 6145695 YP_001746239.1 CDS rhaA NC_010498.1 4397151 4398410 R catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase complement(4397151..4398410) Escherichia coli SMS-3-5 6143792 YP_001746240.1 CDS rhaB NC_010498.1 4398407 4399876 R catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase complement(4398407..4399876) Escherichia coli SMS-3-5 6144349 YP_001746241.1 CDS EcSMS35_4296 NC_010498.1 4399955 4400104 D identified by Glimmer3; putative; hypothetical protein 4399955..4400104 Escherichia coli SMS-3-5 6147314 YP_001746242.1 CDS rhaS NC_010498.1 4400164 4401000 D activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4400164..4401000 Escherichia coli SMS-3-5 6146867 YP_001746243.1 CDS rhaR NC_010498.1 4400984 4401922 D activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4400984..4401922 Escherichia coli SMS-3-5 6143463 YP_001746244.1 CDS rhaT NC_010498.1 4401919 4402953 R transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter complement(4401919..4402953) Escherichia coli SMS-3-5 6144337 YP_001746245.1 CDS sodA NC_010498.1 4403238 4403858 D SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4403238..4403858 Escherichia coli SMS-3-5 6142936 YP_001746246.1 CDS EcSMS35_4301 NC_010498.1 4403887 4404015 R hypothetical protein complement(4403887..4404015) Escherichia coli SMS-3-5 6143860 YP_001746247.1 CDS kdgT NC_010498.1 4404112 4405101 D transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4404112..4405101 Escherichia coli SMS-3-5 6146417 YP_001746248.1 CDS EcSMS35_4303 NC_010498.1 4405250 4405924 D identified by match to protein family HMM PF03473; match to protein family HMM PF03475; hypothetical protein 4405250..4405924 Escherichia coli SMS-3-5 6146513 YP_001746249.1 CDS cpxA NC_010498.1 4406029 4407402 R part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein complement(4406029..4407402) Escherichia coli SMS-3-5 6143490 YP_001746250.1 CDS cpxR NC_010498.1 4407399 4408097 R response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR complement(4407399..4408097) Escherichia coli SMS-3-5 6142971 YP_001746251.1 CDS cpxP NC_010498.1 4408244 4408747 D repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4408244..4408747 Escherichia coli SMS-3-5 6142624 YP_001746252.1 CDS EcSMS35_4307 NC_010498.1 4408933 4409913 R identified by match to protein family HMM PF00589; phage integrase family site specific recombinase complement(4408933..4409913) Escherichia coli SMS-3-5 6147078 YP_001746253.1 CDS cox NC_010498.1 4410429 4410701 D identified by similarity to SP:P07695; regulatory protein Cox 4410429..4410701 Escherichia coli SMS-3-5 6144578 YP_001746254.1 CDS EcSMS35_4309 NC_010498.1 4410704 4410874 D identified by similarity to GB:AAP04469.1; hypothetical protein 4410704..4410874 Escherichia coli SMS-3-5 6143921 YP_001746255.1 CDS EcSMS35_4310 NC_010498.1 4410880 4411371 D putative replication gene B protein 4410880..4411371 Escherichia coli SMS-3-5 6145605 YP_001746256.1 CDS EcSMS35_4311 NC_010498.1 4411435 4411659 D hypothetical protein 4411435..4411659 Escherichia coli SMS-3-5 6144892 YP_001746257.1 CDS EcSMS35_4312 NC_010498.1 4411659 4411961 D hypothetical protein 4411659..4411961 Escherichia coli SMS-3-5 6144612 YP_001746258.1 CDS EcSMS35_4313 NC_010498.1 4411961 4412185 D identified by match to protein family HMM PF01258; match to protein family HMM TIGR02419; C4-type zinc finger DksA/TraR family protein 4411961..4412185 Escherichia coli SMS-3-5 6143958 YP_001746259.1 CDS EcSMS35_4314 NC_010498.1 4412182 4412457 D hypothetical protein 4412182..4412457 Escherichia coli SMS-3-5 6145616 YP_001746260.1 CDS EcSMS35_4315 NC_010498.1 4412447 4414732 D identified by similarity to SP:Q06419; match to protein family HMM PF05840; replication gene A protein 4412447..4414732 Escherichia coli SMS-3-5 6144994 YP_001746261.1 CDS EcSMS35_4316 NC_010498.1 4414732 4415184 D identified by similarity to GB:AAP04476.1; hypothetical protein 4414732..4415184 Escherichia coli SMS-3-5 6146067 YP_001746262.1 CDS EcSMS35_4317 NC_010498.1 4415256 4415378 R identified by Glimmer3; putative; hypothetical protein complement(4415256..4415378) Escherichia coli SMS-3-5 6145415 YP_001746263.1 CDS EcSMS35_4319 NC_010498.1 4415633 4416571 D identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; DNA-cytosine methyltransferase family protein 4415633..4416571 Escherichia coli SMS-3-5 6143903 YP_001746264.1 CDS EcSMS35_4318 NC_010498.1 4416568 4417593 R identified by similarity to GB:AAN28261.1; hypothetical protein complement(4416568..4417593) Escherichia coli SMS-3-5 6144989 YP_001746265.1 CDS EcSMS35_4320 NC_010498.1 4417598 4418803 R identified by similarity to GB:AAN28262.1; hypothetical protein complement(4417598..4418803) Escherichia coli SMS-3-5 6144586 YP_001746266.1 CDS EcSMS35_4321 NC_010498.1 4418887 4419048 D identified by Glimmer3; putative; hypothetical protein 4418887..4419048 Escherichia coli SMS-3-5 6145631 YP_001746267.1 CDS EcSMS35_4322 NC_010498.1 4419087 4420121 R identified by match to protein family HMM PF04860; match to protein family HMM TIGR01540; PBSX family phage portal protein complement(4419087..4420121) Escherichia coli SMS-3-5 6147244 YP_001746268.1 CDS EcSMS35_4323 NC_010498.1 4420121 4421893 R identified by similarity to SP:P25479; match to protein family HMM PF03237; match to protein family HMM PF06056; phage large terminase subunit GpP complement(4420121..4421893) Escherichia coli SMS-3-5 6142866 YP_001746269.1 CDS EcSMS35_4324 NC_010498.1 4422067 4422921 D identified by match to protein family HMM PF05929; phage capsid scaffolding protein GpO 4422067..4422921 Escherichia coli SMS-3-5 6143273 YP_001746270.1 CDS EcSMS35_4325 NC_010498.1 4422980 4424053 D identified by match to protein family HMM PF05125; match to protein family HMM TIGR01551; phage major capsid protein GpN 4422980..4424053 Escherichia coli SMS-3-5 6144048 YP_001746271.1 CDS EcSMS35_4326 NC_010498.1 4424057 4424800 D identified by similarity to SP:P25476; match to protein family HMM PF05944; phage small terminase subunit GpM 4424057..4424800 Escherichia coli SMS-3-5 6144633 YP_001746272.1 CDS EcSMS35_4327 NC_010498.1 4424900 4425409 D identified by similarity to SP:P25475; match to protein family HMM PF05926; phage head completion protein GPL 4424900..4425409 Escherichia coli SMS-3-5 6144134 YP_001746273.1 CDS EcSMS35_4328 NC_010498.1 4425409 4425612 D identified by similarity to SP:P51772; match to protein family HMM PF05489; phage tail protein GpX 4425409..4425612 Escherichia coli SMS-3-5 6143299 YP_001746274.1 CDS EcSMS35_4329 NC_010498.1 4425616 4425897 D identified by similarity to SP:P51773; match to protein family HMM PF04550; phage holin GpY 4425616..4425897 Escherichia coli SMS-3-5 6142843 YP_001746275.1 CDS EcSMS35_4330 NC_010498.1 4425897 4426394 D identified by match to protein family HMM PF00959; phage lysozyme 4425897..4426394 Escherichia coli SMS-3-5 6143913 YP_001746276.1 CDS EcSMS35_4331 NC_010498.1 4426409 4426834 D identified by similarity to SP:P51769; phage lysis protein LysA 4426409..4426834 Escherichia coli SMS-3-5 6145794 YP_001746277.1 CDS EcSMS35_4332 NC_010498.1 4426822 4427247 D identified by similarity to SP:P51770; phage lysis timing protein LysB 4426822..4427247 Escherichia coli SMS-3-5 6144986 YP_001746278.1 CDS EcSMS35_4333 NC_010498.1 4427102 4427392 D identified by similarity to GB:AAM83596.1; phage lysis protein LysC 4427102..4427392 Escherichia coli SMS-3-5 6146828 YP_001746279.1 CDS EcSMS35_4334 NC_010498.1 4427355 4427822 D identified by match to protein family HMM PF06891; phage tail completion protein GpR 4427355..4427822 Escherichia coli SMS-3-5 6146708 YP_001746280.1 CDS EcSMS35_4335 NC_010498.1 4427815 4428267 D identified by match to protein family HMM PF05069; match to protein family HMM TIGR01635; phage virion morphogenesis protein GpS 4427815..4428267 Escherichia coli SMS-3-5 6143359 YP_001746281.1 CDS EcSMS35_4336 NC_010498.1 4428339 4429124 R identified by similarity to SP:P36935; hypothetical protein complement(4428339..4429124) Escherichia coli SMS-3-5 6146050 YP_001746282.1 CDS EcSMS35_4337 NC_010498.1 4429208 4429843 D identified by similarity to SP:P31340; match to protein family HMM PF04717; match to protein family HMM TIGR01644; phage baseplate assembly protein GpV 4429208..4429843 Escherichia coli SMS-3-5 6145536 YP_001746283.1 CDS EcSMS35_4338 NC_010498.1 4429840 4430187 D identified by similarity to SP:P51768; match to protein family HMM PF04965; baseplate assembly protein GPW 4429840..4430187 Escherichia coli SMS-3-5 6145040 YP_001746284.1 CDS EcSMS35_4339 NC_010498.1 4430192 4431100 D identified by match to protein family HMM PF04865; baseplate assembly protein GpJ 4430192..4431100 Escherichia coli SMS-3-5 6146955 YP_001746285.1 CDS EcSMS35_4340 NC_010498.1 4431093 4431623 D identified by match to protein family HMM TIGR01634; phage tail protein GpI 4431093..4431623 Escherichia coli SMS-3-5 6146352 YP_001746286.1 CDS EcSMS35_4341 NC_010498.1 4431634 4433655 D identified by match to protein family HMM PF03406; putative phage tail fiber protein 4431634..4433655 Escherichia coli SMS-3-5 6143363 YP_001746287.1 CDS EcSMS35_4342 NC_010498.1 4433657 4434184 D identified by similarity to SP:P26699; match to protein family HMM PF02413; tail fiber assembly protein GpG 4433657..4434184 Escherichia coli SMS-3-5 6142797 YP_001746288.1 CDS EcSMS35_4343 NC_010498.1 4434400 4435299 D identified by similarity to GB:ABM26356.1; hypothetical protein 4434400..4435299 Escherichia coli SMS-3-5 6144817 YP_001746289.1 CDS EcSMS35_4344 NC_010498.1 4435462 4435599 R identified by Glimmer3; putative; hypothetical protein complement(4435462..4435599) Escherichia coli SMS-3-5 6144301 YP_001746290.1 CDS EcSMS35_4345 NC_010498.1 4435619 4436809 D identified by match to protein family HMM PF04984; phage tail sheath protein 4435619..4436809 Escherichia coli SMS-3-5 6143764 YP_001746291.1 CDS EcSMS35_4346 NC_010498.1 4436822 4437340 D identified by match to protein family HMM PF04985; match to protein family HMM TIGR01611; phage major tail tube protein FII 4436822..4437340 Escherichia coli SMS-3-5 6147342 YP_001746292.1 CDS EcSMS35_4347 NC_010498.1 4437397 4437672 D identified by match to protein family HMM PF06158; phage tail protein E 4437397..4437672 Escherichia coli SMS-3-5 6143956 YP_001746293.1 CDS EcSMS35_4348 NC_010498.1 4437705 4437824 D identified by match to protein family HMM PF06528; phage tail protein P2 4437705..4437824 Escherichia coli SMS-3-5 6144738 YP_001746294.1 CDS EcSMS35_4349 NC_010498.1 4437817 4440264 D identified by match to protein family HMM TIGR01760; TP901 family phage tail tape measure protein 4437817..4440264 Escherichia coli SMS-3-5 6142615 YP_001746295.1 CDS gpU NC_010498.1 4440279 4440758 D identified by match to protein family HMM PF06995; phage protein gpU 4440279..4440758 Escherichia coli SMS-3-5 6143149 YP_001746296.1 CDS EcSMS35_4351 NC_010498.1 4440758 4441921 D identified by match to protein family HMM PF05954; phage late control gene D protein 4440758..4441921 Escherichia coli SMS-3-5 6143574 YP_001746297.1 CDS EcSMS35_4352 NC_010498.1 4442003 4442221 D in E. coli K-12 this is in prophage P2 remnant; DNA-binding transcriptional regulator 4442003..4442221 Escherichia coli SMS-3-5 6146753 YP_001746298.1 CDS EcSMS35_4353 NC_010498.1 4442260 4443588 R identified by match to protein family HMM PF01609; IS4 transposase complement(4442260..4443588) Escherichia coli SMS-3-5 6145049 YP_001746299.1 CDS EcSMS35_4354 NC_010498.1 4443760 4443882 D identified by Glimmer3; putative; hypothetical protein 4443760..4443882 Escherichia coli SMS-3-5 6145575 YP_001746300.1 CDS fieF NC_010498.1 4443897 4444799 D member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4443897..4444799 Escherichia coli SMS-3-5 6145704 YP_001746301.1 CDS pfkA NC_010498.1 4444980 4445942 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4444980..4445942 Escherichia coli SMS-3-5 6144511 YP_001746302.1 CDS sbp NC_010498.1 4446262 4447251 D identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971; sulfate transporter subunit 4446262..4447251 Escherichia coli SMS-3-5 6145051 YP_001746303.1 CDS cdh NC_010498.1 4447358 4448113 D identified by match to protein family HMM PF02611; match to protein family HMM TIGR00672; CDP-diacylglycerol pyrophosphatase 4447358..4448113 Escherichia coli SMS-3-5 6146014 YP_001746304.1 CDS tpiA NC_010498.1 4448168 4448935 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(4448168..4448935) Escherichia coli SMS-3-5 6144025 YP_001746305.1 CDS EcSMS35_4360 NC_010498.1 4449043 4449642 R identified by match to protein family HMM PF07305; hypothetical protein complement(4449043..4449642) Escherichia coli SMS-3-5 6144566 YP_001746306.1 CDS EcSMS35_4361 NC_010498.1 4449743 4450183 D identified by match to protein family HMM PF05656; hypothetical protein 4449743..4450183 Escherichia coli SMS-3-5 6142739 YP_001746307.1 CDS EcSMS35_4362 NC_010498.1 4450395 4450694 D identified by match to protein family HMM PF04175; match to protein family HMM TIGR00743; hypothetical protein 4450395..4450694 Escherichia coli SMS-3-5 6142644 YP_001746308.1 CDS uspD NC_010498.1 4450721 4451149 D with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4450721..4451149 Escherichia coli SMS-3-5 6146591 YP_001746309.1 CDS fpr NC_010498.1 4451154 4451900 R identified by match to protein family HMM PF00175; match to protein family HMM PF00970; ferredoxin-NADP reductase complement(4451154..4451900) Escherichia coli SMS-3-5 6147312 YP_001746310.1 CDS glpX NC_010498.1 4451997 4453007 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(4451997..4453007) Escherichia coli SMS-3-5 6147330 YP_001746311.1 CDS glpK NC_010498.1 4453142 4454650 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4453142..4454650) Escherichia coli SMS-3-5 6146035 YP_001746312.1 CDS glpF NC_010498.1 4454673 4455518 R identified by similarity to SP:P0AER0; match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein complement(4454673..4455518) Escherichia coli SMS-3-5 6144749 YP_001746313.1 CDS EcSMS35_4368 NC_010498.1 4455943 4456188 D identified by match to protein family HMM PF06005; hypothetical protein 4455943..4456188 Escherichia coli SMS-3-5 6145461 YP_001746314.1 CDS EcSMS35_4369 NC_010498.1 4456227 4456943 R identified by Glimmer3; putative; hypothetical protein complement(4456227..4456943) Escherichia coli SMS-3-5 6143137 YP_001746315.1 CDS EcSMS35_4370 NC_010498.1 4456976 4457650 R identified by Glimmer3; putative; hypothetical protein complement(4456976..4457650) Escherichia coli SMS-3-5 6143932 YP_001746316.1 CDS rraA NC_010498.1 4457710 4458195 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(4457710..4458195) Escherichia coli SMS-3-5 6146865 YP_001746317.1 CDS menA NC_010498.1 4458288 4459226 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(4458288..4459226) Escherichia coli SMS-3-5 6143401 YP_001746318.1 CDS hslU NC_010498.1 4459281 4460612 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(4459281..4460612) Escherichia coli SMS-3-5 6146544 YP_001746319.1 CDS hslV NC_010498.1 4460622 4461152 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(4460622..4461152) Escherichia coli SMS-3-5 6147228 YP_001746320.1 CDS ftsN NC_010498.1 4461245 4462204 R identified by match to protein family HMM PF05036; match to protein family HMM TIGR02223; essential cell division protein FtsN complement(4461245..4462204) Escherichia coli SMS-3-5 6145024 YP_001746321.1 CDS cytR NC_010498.1 4462296 4463321 R negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR complement(4462296..4463321) Escherichia coli SMS-3-5 6147387 YP_001746322.1 CDS priA NC_010498.1 4463477 4465675 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(4463477..4465675) Escherichia coli SMS-3-5 6145623 YP_001746323.1 CDS rpmE NC_010498.1 4465878 4466090 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4465878..4466090 Escherichia coli SMS-3-5 6146133 YP_001746324.1 CDS EcSMS35_4379 NC_010498.1 4466151 4466759 R member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase complement(4466151..4466759) Escherichia coli SMS-3-5 6144685 YP_001746325.1 CDS metJ NC_010498.1 4466819 4467136 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(4466819..4467136) Escherichia coli SMS-3-5 6145211 YP_001746326.1 CDS metB NC_010498.1 4467413 4468573 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4467413..4468573 Escherichia coli SMS-3-5 6143486 YP_001746327.1 CDS metL NC_010498.1 4468576 4471008 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4468576..4471008 Escherichia coli SMS-3-5 6144029 YP_001746328.1 CDS EcSMS35_4383 NC_010498.1 4471015 4471158 D identified by Glimmer3; putative; hypothetical protein 4471015..4471158 Escherichia coli SMS-3-5 6147377 YP_001746329.1 CDS tsx2 NC_010498.1 4471225 4472085 R identified by similarity to SP:P40786; match to protein family HMM PF03502; nucleoside-specific channel-forming protein Tsx complement(4471225..4472085) Escherichia coli SMS-3-5 6142961 YP_001746330.1 CDS EcSMS35_4385 NC_010498.1 4472163 4473782 R identified by match to protein family HMM PF00149; match to protein family HMM PF02872; serine/threonine protein phosphatase family protein complement(4472163..4473782) Escherichia coli SMS-3-5 6146414 YP_001746331.1 CDS EcSMS35_4386 NC_010498.1 4473823 4475373 R identified by match to protein family HMM PF00149; match to protein family HMM PF02872; serine/threonine protein phosphatase family protein complement(4473823..4475373) Escherichia coli SMS-3-5 6143196 YP_001746332.1 CDS EcSMS35_4387 NC_010498.1 4475606 4476733 R identified by similarity to GB:CAD09521.1; hypothetical protein complement(4475606..4476733) Escherichia coli SMS-3-5 6144833 YP_001746333.1 CDS EcSMS35_4388 NC_010498.1 4476866 4478419 D identified by match to protein family HMM PF00149; match to protein family HMM PF02872; serine/threonine protein phosphatase family protein 4476866..4478419 Escherichia coli SMS-3-5 6142929 YP_001746334.1 CDS metF NC_010498.1 4478801 4479691 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4478801..4479691 Escherichia coli SMS-3-5 6145862 YP_001746335.1 CDS katG NC_010498.1 4480020 4482200 D identified by match to protein family HMM PF00141; match to protein family HMM TIGR00198; catalase/peroxidase HPI 4480020..4482200 Escherichia coli SMS-3-5 6144291 YP_001746336.1 CDS EcSMS35_4391 NC_010498.1 4482294 4483199 D identified by match to protein family HMM PF00892; putative transporter 4482294..4483199 Escherichia coli SMS-3-5 6146936 YP_001746337.1 CDS EcSMS35_4392 NC_010498.1 4483224 4483841 R identified by match to protein family HMM PF06940; hypothetical protein complement(4483224..4483841) Escherichia coli SMS-3-5 6145351 YP_001746338.1 CDS gldA NC_010498.1 4484116 4485219 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(4484116..4485219) Escherichia coli SMS-3-5 6143067 YP_001746339.1 CDS fsaB NC_010498.1 4485230 4485892 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(4485230..4485892) Escherichia coli SMS-3-5 6146338 YP_001746340.1 CDS ptsA NC_010498.1 4485904 4488405 R identified by match to protein family HMM PF00359; match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; multi-phosphoryl transfer protein 2 complement(4485904..4488405) Escherichia coli SMS-3-5 6144211 YP_001746341.1 CDS EcSMS35_4396 NC_010498.1 4488714 4489793 D FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 4488714..4489793 Escherichia coli SMS-3-5 6144054 YP_001746342.1 CDS EcSMS35_4397 NC_010498.1 4489808 4490128 D FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 4489808..4490128 Escherichia coli SMS-3-5 6146101 YP_001746343.1 CDS pflD NC_010498.1 4490179 4492476 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 4490179..4492476 Escherichia coli SMS-3-5 6145430 YP_001746344.1 CDS EcSMS35_4399 NC_010498.1 4492442 4493320 D identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate lyase II activase 4492442..4493320 Escherichia coli SMS-3-5 6144697 YP_001746345.1 CDS EcSMS35_4401 NC_010498.1 4493322 4493663 D FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 4493322..4493663 Escherichia coli SMS-3-5 6144530 YP_001746346.1 CDS EcSMS35_4400 NC_010498.1 4493650 4494501 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(4493650..4494501) Escherichia coli SMS-3-5 6143065 YP_001746347.1 CDS EcSMS35_4402 NC_010498.1 4494650 4496383 R identified by match to protein family HMM PF00884; hypothetical protein complement(4494650..4496383) Escherichia coli SMS-3-5 6146350 YP_001746348.1 CDS ppc NC_010498.1 4496566 4499217 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(4496566..4499217) Escherichia coli SMS-3-5 6145036 YP_001746349.1 CDS argE NC_010498.1 4499519 4500670 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(4499519..4500670) Escherichia coli SMS-3-5 6147257 YP_001746350.1 CDS argC NC_010498.1 4500824 4501828 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4500824..4501828 Escherichia coli SMS-3-5 6144314 YP_001746351.1 CDS argB NC_010498.1 4501839 4502612 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4501839..4502612 Escherichia coli SMS-3-5 6146135 YP_001746352.1 CDS argH NC_010498.1 4502673 4504046 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4502673..4504046 Escherichia coli SMS-3-5 6143737 YP_001746353.1 CDS oxyR NC_010498.1 4504313 4505230 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4504313..4505230 Escherichia coli SMS-3-5 6144393 YP_001746354.1 CDS sthA NC_010498.1 4505213 4506613 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(4505213..4506613) Escherichia coli SMS-3-5 6144080 YP_001746355.1 CDS fabR NC_010498.1 4506891 4507595 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4506891..4507595 Escherichia coli SMS-3-5 6145196 YP_001746356.1 CDS EcSMS35_4411 NC_010498.1 4507595 4507954 D identified by match to protein family HMM PF07226; hypothetical protein 4507595..4507954 Escherichia coli SMS-3-5 6145320 YP_001746357.1 CDS trmA NC_010498.1 4507994 4509094 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(4507994..4509094) Escherichia coli SMS-3-5 6145990 YP_001746358.1 CDS btuB NC_010498.1 4509463 4511307 D involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4509463..4511307 Escherichia coli SMS-3-5 6146182 YP_001746359.1 CDS murI NC_010498.1 4511321 4512109 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4511321..4512109 Escherichia coli SMS-3-5 6146847 YP_001746360.1 CDS murB NC_010498.1 4517629 4518657 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4517629..4518657 Escherichia coli SMS-3-5 6143730 YP_001746361.1 CDS birA NC_010498.1 4518654 4519619 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4518654..4519619 Escherichia coli SMS-3-5 6143412 YP_001746362.1 CDS coaA NC_010498.1 4519648 4520598 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(4519648..4520598) Escherichia coli SMS-3-5 6146628 YP_001746363.1 CDS EcSMS35_4423 NC_010498.1 4520581 4520775 D identified by similarity to GB:BAC18512.1; hypothetical protein 4520581..4520775 Escherichia coli SMS-3-5 6144905 YP_001746364.1 CDS tuf1 NC_010498.1 4521516 4522700 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4521516..4522700 Escherichia coli SMS-3-5 6143658 YP_001746365.1 CDS secE NC_010498.1 4522930 4523313 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4522930..4523313 Escherichia coli SMS-3-5 6145533 YP_001746366.1 CDS nusG NC_010498.1 4523315 4523860 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4523315..4523860 Escherichia coli SMS-3-5 6143905 YP_001746367.1 CDS rplK NC_010498.1 4524019 4524447 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4524019..4524447 Escherichia coli SMS-3-5 6147034 YP_001746368.1 CDS rplA NC_010498.1 4524451 4525155 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4524451..4525155 Escherichia coli SMS-3-5 6145216 YP_001746369.1 CDS rplJ NC_010498.1 4525447 4525944 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4525447..4525944 Escherichia coli SMS-3-5 6146439 YP_001746370.1 CDS rplL NC_010498.1 4526011 4526376 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4526011..4526376 Escherichia coli SMS-3-5 6143016 YP_001746371.1 CDS rpoB NC_010498.1 4526696 4530724 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4526696..4530724 Escherichia coli SMS-3-5 6145860 YP_001746372.1 CDS rpoC NC_010498.1 4530801 4535024 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4530801..4535024 Escherichia coli SMS-3-5 6144315 YP_001746373.1 CDS thiH NC_010498.1 4535266 4536399 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(4535266..4536399) Escherichia coli SMS-3-5 6146882 YP_001746374.1 CDS thiG NC_010498.1 4536396 4537211 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(4536396..4537211) Escherichia coli SMS-3-5 6145305 YP_001746375.1 CDS thiS NC_010498.1 4537168 4537368 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(4537168..4537368) Escherichia coli SMS-3-5 6143138 YP_001746376.1 CDS thiF NC_010498.1 4537352 4538107 R identified by match to protein family HMM PF00899; match to protein family HMM PF05237; match to protein family HMM TIGR02356; thiazole biosynthesis adenylyltransferase ThiF complement(4537352..4538107) Escherichia coli SMS-3-5 6146327 YP_001746377.1 CDS thiE NC_010498.1 4538100 4538735 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(4538100..4538735) Escherichia coli SMS-3-5 6144216 YP_001746378.1 CDS thiC NC_010498.1 4538735 4540630 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(4538735..4540630) Escherichia coli SMS-3-5 6144890 YP_001746379.1 CDS rsd NC_010498.1 4540863 4541339 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(4540863..4541339) Escherichia coli SMS-3-5 6144201 YP_001746380.1 CDS nudC NC_010498.1 4541434 4542207 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4541434..4542207 Escherichia coli SMS-3-5 6145978 YP_001746381.1 CDS hemE NC_010498.1 4542247 4543311 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4542247..4543311 Escherichia coli SMS-3-5 6144888 YP_001746382.1 CDS nfi NC_010498.1 4543321 4543992 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4543321..4543992 Escherichia coli SMS-3-5 6142741 YP_001746383.1 CDS EcSMS35_4447 NC_010498.1 4544035 4544625 D identified by match to protein family HMM PF04222; hypothetical protein 4544035..4544625 Escherichia coli SMS-3-5 6145636 YP_001746384.1 CDS hupA NC_010498.1 4544812 4545084 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4544812..4545084 Escherichia coli SMS-3-5 6144200 YP_001746385.1 CDS EcSMS35_4449 NC_010498.1 4545157 4545792 D identified by match to protein family HMM PF07356; hypothetical protein 4545157..4545792 Escherichia coli SMS-3-5 6146210 YP_001746386.1 CDS zraP NC_010498.1 4545794 4546213 R zinc resistance protein complement(4545794..4546213) Escherichia coli SMS-3-5 6146730 YP_001746387.1 CDS EcSMS35_4451 NC_010498.1 4546216 4546344 R identified by Glimmer3; putative; hypothetical protein complement(4546216..4546344) Escherichia coli SMS-3-5 6143383 YP_001746388.1 CDS zraS NC_010498.1 4546451 4547827 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein ZraS 4546451..4547827 Escherichia coli SMS-3-5 6143174 YP_001746389.1 CDS zraR NC_010498.1 4547824 4549149 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4547824..4549149 Escherichia coli SMS-3-5 6142865 YP_001746390.1 CDS purD NC_010498.1 4549146 4550435 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(4549146..4550435) Escherichia coli SMS-3-5 6144316 YP_001746391.1 CDS purH NC_010498.1 4550447 4552036 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(4550447..4552036) Escherichia coli SMS-3-5 6143023 YP_001746392.1 CDS EcSMS35_4456 NC_010498.1 4552154 4552276 D identified by Glimmer3; putative; hypothetical protein 4552154..4552276 Escherichia coli SMS-3-5 6144802 YP_001746393.1 CDS EcSMS35_4464 NC_010498.1 4558033 4558344 D identified by match to protein family HMM PF01527; IS3 family transposase orfA 4558033..4558344 Escherichia coli SMS-3-5 6145341 YP_001746394.1 CDS EcSMS35_4465 NC_010498.1 4558464 4559210 D identified by match to protein family HMM PF00665; IS3 family transposase orfB 4558464..4559210 Escherichia coli SMS-3-5 6143019 YP_001746395.1 CDS metA NC_010498.1 4559649 4560578 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4559649..4560578 Escherichia coli SMS-3-5 6144772 YP_001746396.1 CDS aceB NC_010498.1 4560847 4562448 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4560847..4562448 Escherichia coli SMS-3-5 6145921 YP_001746397.1 CDS aceA NC_010498.1 4562478 4563782 D identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346; isocitrate lyase 4562478..4563782 Escherichia coli SMS-3-5 6142638 YP_001746398.1 CDS aceK NC_010498.1 4563966 4565690 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4563966..4565690 Escherichia coli SMS-3-5 6146890 YP_001746399.1 CDS iclR NC_010498.1 4565707 4566531 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR complement(4565707..4566531) Escherichia coli SMS-3-5 6144090 YP_001746400.1 CDS metH NC_010498.1 4566731 4570414 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4566731..4570414 Escherichia coli SMS-3-5 6142641 YP_001746401.1 CDS pNaS NC_010498.1 4570634 4572265 D identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704; match to protein family HMM TIGR01013; inorganic phosphate transporter, sodium-dependent 4570634..4572265 Escherichia coli SMS-3-5 6145420 YP_001746402.1 CDS pepE NC_010498.1 4572355 4573044 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(4572355..4573044) Escherichia coli SMS-3-5 6144720 YP_001746403.1 CDS EcSMS35_4475 NC_010498.1 4573167 4573979 R catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(4573167..4573979) Escherichia coli SMS-3-5 6146081 YP_001746404.1 CDS EcSMS35_4476 NC_010498.1 4573972 4575201 R identified by similarity to SP:P37084; match to protein family HMM PF00107; match to protein family HMM PF08240; L-sorbose 1-phosphate reductase complement(4573972..4575201) Escherichia coli SMS-3-5 6145425 YP_001746405.1 CDS EcSMS35_4477 NC_010498.1 4575253 4576077 R identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system mannose/fructose/sorbose family IID subunit complement(4575253..4576077) Escherichia coli SMS-3-5 6146843 YP_001746406.1 CDS EcSMS35_4478 NC_010498.1 4576088 4576885 R identified by match to protein family HMM PF03609; match to protein family HMM TIGR00822; PTS system mannose/fructose/sorbose family IIC subunit complement(4576088..4576885) Escherichia coli SMS-3-5 6142882 YP_001746407.1 CDS EcSMS35_4479 NC_010498.1 4576951 4577445 R identified by match to protein family HMM PF03830; match to protein family HMM TIGR00854; PTS system mannose/fructose/sorbose family IIB subunit complement(4576951..4577445) Escherichia coli SMS-3-5 6143409 YP_001746408.1 CDS EcSMS35_4480 NC_010498.1 4577445 4577852 R identified by match to protein family HMM PF03610; match to protein family HMM TIGR00824; PTS system mannose/fructose/sorbose family IIA subunit complement(4577445..4577852) Escherichia coli SMS-3-5 6145957 YP_001746409.1 CDS EcSMS35_4481 NC_010498.1 4577862 4578668 R Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase complement(4577862..4578668) Escherichia coli SMS-3-5 6145264 YP_001746410.1 CDS sorC NC_010498.1 4578738 4579685 R identified by similarity to SP:P37078; match to protein family HMM PF04198; sorbitol operon regulator SorC complement(4578738..4579685) Escherichia coli SMS-3-5 6145562 YP_001746411.1 CDS rluF NC_010498.1 4580033 4580905 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4580033..4580905 Escherichia coli SMS-3-5 6143901 YP_001746412.1 CDS EcSMS35_4484 NC_010498.1 4580906 4581178 R hypothetical protein complement(4580906..4581178) Escherichia coli SMS-3-5 6146632 YP_001746413.1 CDS lysC NC_010498.1 4581431 4582780 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III complement(4581431..4582780) Escherichia coli SMS-3-5 6144933 YP_001746414.1 CDS pgi NC_010498.1 4583305 4584954 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4583305..4584954 Escherichia coli SMS-3-5 6143454 YP_001746415.1 CDS EcSMS35_4487 NC_010498.1 4585308 4585550 D hypothetical protein 4585308..4585550 Escherichia coli SMS-3-5 6146623 YP_001746416.1 CDS EcSMS35_4488 NC_010498.1 4585664 4586302 D hypothetical protein 4585664..4586302 Escherichia coli SMS-3-5 6142959 YP_001746417.1 CDS EcSMS35_4489 NC_010498.1 4586299 4587036 D identified by match to protein family HMM PF06251; hypothetical protein 4586299..4587036 Escherichia coli SMS-3-5 6143324 YP_001746418.1 CDS EcSMS35_4490 NC_010498.1 4587036 4589132 D identified by match to protein family HMM PF06082; putative lipoprotein 4587036..4589132 Escherichia coli SMS-3-5 6146511 YP_001746419.1 CDS EcSMS35_4491 NC_010498.1 4589179 4589457 R hypothetical protein complement(4589179..4589457) Escherichia coli SMS-3-5 6146938 YP_001746420.1 CDS EcSMS35_4492 NC_010498.1 4589454 4589576 R identified by Glimmer3; putative; hypothetical protein complement(4589454..4589576) Escherichia coli SMS-3-5 6145717 YP_001746421.1 CDS psiE NC_010498.1 4589672 4590082 D identified by match to protein family HMM PF06146; phosphate-starvation-inducible protein PsiE 4589672..4590082 Escherichia coli SMS-3-5 6145967 YP_001746422.1 CDS malG NC_010498.1 4590176 4591066 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(4590176..4591066) Escherichia coli SMS-3-5 6144244 YP_001746423.1 CDS malF NC_010498.1 4591081 4592625 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(4591081..4592625) Escherichia coli SMS-3-5 6144757 YP_001746424.1 CDS malE NC_010498.1 4592779 4593969 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(4592779..4593969) Escherichia coli SMS-3-5 6143609 YP_001746425.1 CDS malK NC_010498.1 4594334 4595449 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4594334..4595449 Escherichia coli SMS-3-5 6143777 YP_001746426.1 CDS lamB NC_010498.1 4595521 4596861 D porin involved in the transport of maltose and maltodextrins; maltoporin 4595521..4596861 Escherichia coli SMS-3-5 6142859 YP_001746427.1 CDS malM NC_010498.1 4597104 4598024 D identified by match to protein family HMM PF07148; maltose regulon periplasmic protein 4597104..4598024 Escherichia coli SMS-3-5 6143605 YP_001746428.1 CDS EcSMS35_4500 NC_010498.1 4598294 4599832 D in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4598294..4599832 Escherichia coli SMS-3-5 6143773 YP_001746429.1 CDS ubiC NC_010498.1 4600055 4600552 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4600055..4600552 Escherichia coli SMS-3-5 6144416 YP_001746430.1 CDS ubiA NC_010498.1 4600565 4601437 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4600565..4601437 Escherichia coli SMS-3-5 6145203 YP_001746431.1 CDS plsB NC_010498.1 4601592 4604075 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(4601592..4604075) Escherichia coli SMS-3-5 6145679 YP_001746432.1 CDS dgkA NC_010498.1 4604186 4604554 D identified by match to protein family HMM PF01219; diacylglycerol kinase 4604186..4604554 Escherichia coli SMS-3-5 6147183 YP_001746433.1 CDS lexA NC_010498.1 4604664 4605272 D Represses a number of genes involved in the response to DNA damage; LexA repressor 4604664..4605272 Escherichia coli SMS-3-5 6145240 YP_001746434.1 CDS dinF NC_010498.1 4605345 4606670 D identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible SOS response protein 4605345..4606670 Escherichia coli SMS-3-5 6143547 YP_001746435.1 CDS EcSMS35_4507 NC_010498.1 4606786 4606995 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4606786..4606995 Escherichia coli SMS-3-5 6146261 YP_001746436.1 CDS zur NC_010498.1 4607037 4607552 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(4607037..4607552) Escherichia coli SMS-3-5 6146300 YP_001746437.1 CDS EcSMS35_4509 NC_010498.1 4607870 4608874 D identified by similarity to GB:ABB68502.1; hypothetical protein 4607870..4608874 Escherichia coli SMS-3-5 6143110 YP_001746438.1 CDS dusA NC_010498.1 4609254 4610273 D identified by match to protein family HMM PF01207; match to protein family HMM TIGR00742; tRNA-dihydrouridine synthase A 4609254..4610273 Escherichia coli SMS-3-5 6145911 YP_001746439.1 CDS pspG NC_010498.1 4610425 4610649 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4610425..4610649 Escherichia coli SMS-3-5 6147006 YP_001746440.1 CDS qor NC_010498.1 4610815 4611798 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; quinone oxidoreductase, NADPH-dependent complement(4610815..4611798) Escherichia coli SMS-3-5 6144199 YP_001746441.1 CDS dnaB NC_010498.1 4611881 4613296 D unwinds double stranded DNA; replicative DNA helicase 4611881..4613296 Escherichia coli SMS-3-5 6145859 YP_001746442.1 CDS alr NC_010498.1 4613349 4614428 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4613349..4614428 Escherichia coli SMS-3-5 6147339 YP_001746443.1 CDS tyrB NC_010498.1 4614681 4615874 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4614681..4615874 Escherichia coli SMS-3-5 6144858 YP_001746444.1 CDS EcSMS35_4516 NC_010498.1 4616097 4616600 R hypothetical protein complement(4616097..4616600) Escherichia coli SMS-3-5 6143102 YP_001746445.1 CDS aphA NC_010498.1 4617001 4617714 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4617001..4617714 Escherichia coli SMS-3-5 6147343 YP_001746446.1 CDS EcSMS35_4518 NC_010498.1 4617825 4618241 D yjbQ; identified by match to protein family HMM PF01894; match to protein family HMM TIGR00149; hypothetical protein 4617825..4618241 Escherichia coli SMS-3-5 6145729 YP_001746447.1 CDS EcSMS35_4519 NC_010498.1 4618245 4618601 D identified by match to protein family HMM PF04237; hypothetical protein 4618245..4618601 Escherichia coli SMS-3-5 6143890 YP_001746448.1 CDS uvrA NC_010498.1 4618636 4621458 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(4618636..4621458) Escherichia coli SMS-3-5 6144389 YP_001746449.1 CDS ssb2 NC_010498.1 4621713 4622249 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4621713..4622249 Escherichia coli SMS-3-5 6143470 YP_001746450.1 CDS EcSMS35_4522 NC_010498.1 4622348 4622629 R hypothetical protein complement(4622348..4622629) Escherichia coli SMS-3-5 6146494 YP_001746451.1 CDS EcSMS35_4523 NC_010498.1 4623059 4624645 D identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 4623059..4624645 Escherichia coli SMS-3-5 6147170 YP_001746452.1 CDS soxS NC_010498.1 4624648 4624971 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(4624648..4624971) Escherichia coli SMS-3-5 6145128 YP_001746453.1 CDS soxR NC_010498.1 4625057 4625521 D identified by match to protein family HMM PF00376; match to protein family HMM PF09278; match to protein family HMM TIGR01950; redox-sensitive transcriptional activator SoxR 4625057..4625521 Escherichia coli SMS-3-5 6145774 YP_001746454.1 CDS EcSMS35_4526 NC_010498.1 4625724 4625837 R identified by Glimmer3; putative; hypothetical protein complement(4625724..4625837) Escherichia coli SMS-3-5 6145133 YP_001746455.1 CDS EcSMS35_4527 NC_010498.1 4626066 4627415 D identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease family inorganic anion transporter 4626066..4627415 Escherichia coli SMS-3-5 6145780 YP_001746456.1 CDS EcSMS35_4528 NC_010498.1 4627566 4629215 D yjcE; identified by match to protein family HMM PF00999; match to protein family HMM TIGR00831; Na+/H+ antiporter 4627566..4629215 Escherichia coli SMS-3-5 6145685 YP_001746457.1 CDS actP NC_010498.1 4629297 4630946 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(4629297..4630946) Escherichia coli SMS-3-5 6146251 YP_001746458.1 CDS EcSMS35_4530 NC_010498.1 4630943 4631257 R identified by match to protein family HMM PF04341; hypothetical protein complement(4630943..4631257) Escherichia coli SMS-3-5 6146776 YP_001746459.1 CDS acsA NC_010498.1 4631470 4633428 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(4631470..4633428) Escherichia coli SMS-3-5 6142923 YP_001746460.1 CDS nrfA NC_010498.1 4633821 4635257 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4633821..4635257 Escherichia coli SMS-3-5 6143161 YP_001746461.1 CDS nrfB NC_010498.1 4635303 4635869 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4635303..4635869 Escherichia coli SMS-3-5 6143966 YP_001746462.1 CDS nrfC NC_010498.1 4635866 4636537 D identified by match to protein family HMM PF00037; match to protein family HMM TIGR01409; match to protein family HMM TIGR03149; cytochrome c nitrite reductase, Fe-S protein 4635866..4636537 Escherichia coli SMS-3-5 6144016 YP_001746463.1 CDS nrfD NC_010498.1 4636534 4637490 D identified by match to protein family HMM PF03916; match to protein family HMM TIGR03148; nrfD protein 4636534..4637490 Escherichia coli SMS-3-5 6144499 YP_001746464.1 CDS nrfE NC_010498.1 4637546 4639228 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4637546..4639228 Escherichia coli SMS-3-5 6146496 YP_001746465.1 CDS nrfF NC_010498.1 4639221 4639604 D identified by match to protein family HMM PF03918; match to protein family HMM TIGR03147; formate-dependent nitrite reductase complex subunit NrfF 4639221..4639604 Escherichia coli SMS-3-5 6147197 YP_001746466.1 CDS nrfG NC_010498.1 4639601 4640197 D identified by match to protein family HMM PF00515; match to protein family HMM PF07719; formate-dependent nitrite reductase complex subunit NrfG 4639601..4640197 Escherichia coli SMS-3-5 6145315 YP_001746467.1 CDS EcSMS35_4539 NC_010498.1 4640331 4640462 R identified by Glimmer3; putative; hypothetical protein complement(4640331..4640462) Escherichia coli SMS-3-5 6147214 YP_001746468.1 CDS gltP NC_010498.1 4640539 4641852 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4640539..4641852 Escherichia coli SMS-3-5 6147026 YP_001746469.1 CDS EcSMS35_4541 NC_010498.1 4642044 4642733 R identified by match to protein family HMM PF08238; Sel1 repeat-containing protein complement(4642044..4642733) Escherichia coli SMS-3-5 6143334 YP_001746470.1 CDS fdhF NC_010498.1 4642827 4644974 R Selenoprotein. identified by similarity to SP:P07658; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01591; formate dehydrogenase H, alpha subunit, selenocysteine-containing complement(4642827..4644974) Escherichia coli SMS-3-5 6146683 YP_001746471.1 CDS EcSMS35_4543 NC_010498.1 4645036 4645149 D identified by Glimmer3; putative; hypothetical protein 4645036..4645149 Escherichia coli SMS-3-5 6143106 YP_001746472.1 CDS EcSMS35_4544 NC_010498.1 4645172 4646638 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP complement(4645172..4646638) Escherichia coli SMS-3-5 6144744 YP_001746473.1 CDS mdtO NC_010498.1 4646635 4648686 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(4646635..4648686) Escherichia coli SMS-3-5 6145846 YP_001746474.1 CDS mdtN NC_010498.1 4648686 4649717 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(4648686..4649717) Escherichia coli SMS-3-5 6145357 YP_001746475.1 CDS EcSMS35_4547 NC_010498.1 4649736 4650011 R hypothetical protein complement(4649736..4650011) Escherichia coli SMS-3-5 6145687 YP_001746476.1 CDS EcSMS35_4548 NC_010498.1 4650128 4650247 R identified by Glimmer3; putative; hypothetical protein complement(4650128..4650247) Escherichia coli SMS-3-5 6145801 YP_001746477.1 CDS EcSMS35_4549 NC_010498.1 4650220 4652205 R identified by match to protein family HMM PF00753; metallo-beta-lactamase family protein complement(4650220..4652205) Escherichia coli SMS-3-5 6144367 YP_001746478.1 CDS alsK NC_010498.1 4652478 4653407 R identified by similarity to SP:P32718; match to protein family HMM PF00480; D-allose kinase complement(4652478..4653407) Escherichia coli SMS-3-5 6144175 YP_001746479.1 CDS alsE NC_010498.1 4653391 4654086 R identified by similarity to SP:P32719; match to protein family HMM PF00834; allulose-6-phosphate 3-epimerase complement(4653391..4654086) Escherichia coli SMS-3-5 6144375 YP_001746480.1 CDS alsC NC_010498.1 4654097 4655077 R identified by similarity to SP:P32720; match to protein family HMM PF02653; D-allose transporter subunit complement(4654097..4655077) Escherichia coli SMS-3-5 6143888 YP_001746481.1 CDS alsA NC_010498.1 4655056 4656588 R with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein complement(4655056..4656588) Escherichia coli SMS-3-5 6143484 YP_001746482.1 CDS alsB NC_010498.1 4656716 4657657 R identified by similarity to SP:P39265; match to protein family HMM PF00532; D-allose transporter subunit complement(4656716..4657657) Escherichia coli SMS-3-5 6142967 YP_001746483.1 CDS rpiR NC_010498.1 4657710 4658600 R involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR complement(4657710..4658600) Escherichia coli SMS-3-5 6147049 YP_001746484.1 CDS rpiB NC_010498.1 4658959 4659408 D catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4658959..4659408 Escherichia coli SMS-3-5 6145609 YP_001746485.1 CDS EcSMS35_4557 NC_010498.1 4659477 4659806 D hypothetical protein 4659477..4659806 Escherichia coli SMS-3-5 6143157 YP_001746486.1 CDS phnP NC_010498.1 4659841 4660599 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(4659841..4660599) Escherichia coli SMS-3-5 6143749 YP_001746487.1 CDS EcSMS35_4559 NC_010498.1 4660601 4661035 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(4660601..4661035) Escherichia coli SMS-3-5 6145748 YP_001746488.1 CDS phnN NC_010498.1 4661022 4661579 R identified by match to protein family HMM TIGR02322; ribose 1,5-bisphosphokinase complement(4661022..4661579) Escherichia coli SMS-3-5 6147514 YP_001746489.1 CDS phnM NC_010498.1 4661579 4662715 R identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR02318; phosphonate metabolism protein PhnM complement(4661579..4662715) Escherichia coli SMS-3-5 6144637 YP_001746490.1 CDS phnL NC_010498.1 4662712 4663392 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR02324; phosphonate C-P lyase system protein PhnL complement(4662712..4663392) Escherichia coli SMS-3-5 6146444 YP_001746491.1 CDS phnK NC_010498.1 4663503 4664261 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR02323; phosphonate C-P lyase system protein PhnK complement(4663503..4664261) Escherichia coli SMS-3-5 6143498 YP_001746492.1 CDS phnJ NC_010498.1 4664258 4665103 R identified by match to protein family HMM PF06007; phosphonate metabolism protein PhnJ complement(4664258..4665103) Escherichia coli SMS-3-5 6145604 YP_001746493.1 CDS phnI NC_010498.1 4665096 4666160 R identified by match to protein family HMM PF05861; phosphonate metabolism protein PhnI complement(4665096..4666160) Escherichia coli SMS-3-5 6144936 YP_001746494.1 CDS phnH NC_010498.1 4666160 4666744 R identified by match to protein family HMM PF05845; match to protein family HMM TIGR03292; carbon-phosphorus lyase complex subunit complement(4666160..4666744) Escherichia coli SMS-3-5 6144569 YP_001746495.1 CDS phnG NC_010498.1 4666741 4667193 R identified by match to protein family HMM PF06754; match to protein family HMM TIGR03293; phosphonate C-P lyase system protein PhnG complement(4666741..4667193) Escherichia coli SMS-3-5 6143126 YP_001746496.1 CDS phnF NC_010498.1 4667194 4667919 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(4667194..4667919) Escherichia coli SMS-3-5 6146285 YP_001746497.1 CDS phnE NC_010498.1 4667940 4668719 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01097; phosphonate ABC transporter permease complement(4667940..4668719) Escherichia coli SMS-3-5 6146969 YP_001746498.1 CDS phnD NC_010498.1 4668784 4669800 R identified by match to protein family HMM TIGR01098; match to protein family HMM TIGR03431; phosphonate ABC transporter periplasmic phosphonate-binding protein complement(4668784..4669800) Escherichia coli SMS-3-5 6144862 YP_001746499.1 CDS phnC NC_010498.1 4669825 4670613 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR02315; phosphonate/organophosphate ester transporter subunit complement(4669825..4670613) Escherichia coli SMS-3-5 6145342 YP_001746500.1 CDS EcSMS35_4572 NC_010498.1 4670746 4671189 R identified by match to protein family HMM PF00903; hypothetical protein complement(4670746..4671189) Escherichia coli SMS-3-5 6143078 YP_001746501.1 CDS phnA NC_010498.1 4671349 4671762 R identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization operon protein PhnA complement(4671349..4671762) Escherichia coli SMS-3-5 6144293 YP_001746502.1 CDS EcSMS35_4574 NC_010498.1 4672087 4674315 D hypothetical protein 4672087..4674315 Escherichia coli SMS-3-5 6146999 YP_001746503.1 CDS EcSMS35_4575 NC_010498.1 4674312 4675190 D hypothetical protein 4674312..4675190 Escherichia coli SMS-3-5 6147477 YP_001746504.1 CDS proP NC_010498.1 4675454 4676956 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM PF08946; match to protein family HMM TIGR00883; proline/glycine betaine transporter 4675454..4676956 Escherichia coli SMS-3-5 6145370 YP_001746505.1 CDS basS NC_010498.1 4677133 4678233 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein BasS/PmrB complement(4677133..4678233) Escherichia coli SMS-3-5 6144690 YP_001746506.1 CDS basR NC_010498.1 4678234 4678902 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(4678234..4678902) Escherichia coli SMS-3-5 6143186 YP_001746507.1 CDS EcSMS35_4579 NC_010498.1 4678899 4680542 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein complement(4678899..4680542) Escherichia coli SMS-3-5 6143994 YP_001746508.1 CDS adiC NC_010498.1 4680646 4681983 R identified by match to protein family HMM PF00324; arginine:agmatin antiporter complement(4680646..4681983) Escherichia coli SMS-3-5 6147288 YP_001746509.1 CDS adiY NC_010498.1 4682120 4682881 R identified by match to protein family HMM PF00165; transcriptional regulator AdiY complement(4682120..4682881) Escherichia coli SMS-3-5 6142709 YP_001746510.1 CDS EcSMS35_4582 NC_010498.1 4682838 4682975 R identified by Glimmer3; putative; hypothetical protein complement(4682838..4682975) Escherichia coli SMS-3-5 6145625 YP_001746511.1 CDS adiA NC_010498.1 4683217 4685487 R identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; biodegradative arginine decarboxylase complement(4683217..4685487) Escherichia coli SMS-3-5 6146589 YP_001746512.1 CDS melR NC_010498.1 4685683 4686591 R identified by match to protein family HMM PF00165; DNA-binding transcriptional regulator MelR complement(4685683..4686591) Escherichia coli SMS-3-5 6145149 YP_001746513.1 CDS melA NC_010498.1 4686874 4688229 D identified by match to protein family HMM PF02056; alpha-galactosidase 4686874..4688229 Escherichia coli SMS-3-5 6145633 YP_001746514.1 CDS melB NC_010498.1 4688308 4689753 D identified by match to protein family HMM TIGR00792; melibiose:sodium symporter 4688308..4689753 Escherichia coli SMS-3-5 6143390 YP_001746515.1 CDS EcSMS35_4587 NC_010498.1 4689892 4690521 R hypothetical protein complement(4689892..4690521) Escherichia coli SMS-3-5 6144866 YP_001746516.1 CDS fumB NC_010498.1 4690644 4692290 R identified by similarity to SP:P14407; match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; fumarate hydratase class I, anaerobic complement(4690644..4692290) Escherichia coli SMS-3-5 6145226 YP_001746517.1 CDS dcuB NC_010498.1 4692368 4693708 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(4692368..4693708) Escherichia coli SMS-3-5 6145910 YP_001746518.1 CDS EcSMS35_4590 NC_010498.1 4693776 4693934 D identified by Glimmer3; putative; hypothetical protein 4693776..4693934 Escherichia coli SMS-3-5 6146956 YP_001746519.1 CDS dcuR NC_010498.1 4694279 4694998 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(4694279..4694998) Escherichia coli SMS-3-5 6145180 YP_001746520.1 CDS dcuS NC_010498.1 4694995 4696626 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(4694995..4696626) Escherichia coli SMS-3-5 6146536 YP_001746521.1 CDS EcSMS35_4593 NC_010498.1 4696618 4696752 D identified by Glimmer3; putative; hypothetical protein 4696618..4696752 Escherichia coli SMS-3-5 6146222 YP_001746522.1 CDS EcSMS35_4594 NC_010498.1 4696807 4697037 D identified by match to protein family HMM PF06902; hypothetical protein 4696807..4697037 Escherichia coli SMS-3-5 6147233 YP_001746523.1 CDS EcSMS35_4595 NC_010498.1 4697049 4697321 D hypothetical protein 4697049..4697321 Escherichia coli SMS-3-5 6146731 YP_001746524.1 CDS EcSMS35_4596 NC_010498.1 4697640 4697846 D identified by Glimmer3; putative; hypothetical protein 4697640..4697846 Escherichia coli SMS-3-5 6143826 YP_001746525.1 CDS EcSMS35_4597 NC_010498.1 4697874 4698047 D hypothetical protein 4697874..4698047 Escherichia coli SMS-3-5 6142673 YP_001746526.1 CDS lysU NC_010498.1 4698166 4699683 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4698166..4699683) Escherichia coli SMS-3-5 6146751 YP_001746527.1 CDS EcSMS35_4599 NC_010498.1 4699920 4701377 R identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924; amino acid/peptide transporter complement(4699920..4701377) Escherichia coli SMS-3-5 6146213 YP_001746528.1 CDS ldcC2 NC_010498.1 4701436 4703583 R identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; lysine decarboxylase, constitutive complement(4701436..4703583) Escherichia coli SMS-3-5 6146704 YP_001746529.1 CDS cadB NC_010498.1 4703663 4704997 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(4703663..4704997) Escherichia coli SMS-3-5 6145853 YP_001746530.1 CDS cadC NC_010498.1 4705363 4706901 R regulates the cadBA operon; DNA-binding transcriptional activator CadC complement(4705363..4706901) Escherichia coli SMS-3-5 6145699 YP_001746531.1 CDS EcSMS35_4604 NC_010498.1 4707700 4708275 R identified by match to protein family HMM PF00440; putative transcriptional regulator complement(4707700..4708275) Escherichia coli SMS-3-5 6143659 YP_001746532.1 CDS dipZ NC_010498.1 4708312 4710009 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein precursor complement(4708312..4710009) Escherichia coli SMS-3-5 6143776 YP_001746533.1 CDS cutA NC_010498.1 4709985 4710323 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4709985..4710323) Escherichia coli SMS-3-5 6143114 YP_001746534.1 CDS dcuA NC_010498.1 4710439 4711740 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4710439..4711740) Escherichia coli SMS-3-5 6147437 YP_001746535.1 CDS aspA NC_010498.1 4711858 4713294 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4711858..4713294) Escherichia coli SMS-3-5 6145593 YP_001746536.1 CDS fxsA NC_010498.1 4713631 4714107 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4713631..4714107 Escherichia coli SMS-3-5 6144932 YP_001746537.1 CDS EcSMS35_4610 NC_010498.1 4714123 4715379 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH complement(4714123..4715379) Escherichia coli SMS-3-5 6146817 YP_001746538.1 CDS groES NC_010498.1 4715655 4715948 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4715655..4715948 Escherichia coli SMS-3-5 6147247 YP_001746539.1 CDS groEL NC_010498.1 4715992 4717638 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4715992..4717638 Escherichia coli SMS-3-5 6146522 YP_001746540.1 CDS EcSMS35_4613 NC_010498.1 4717773 4718126 D putative lipoprotein 4717773..4718126 Escherichia coli SMS-3-5 6143323 YP_001746541.1 CDS EcSMS35_4614 NC_010498.1 4718176 4719045 R hypothetical protein complement(4718176..4719045) Escherichia coli SMS-3-5 6144619 YP_001746542.1 CDS EcSMS35_4615 NC_010498.1 4719280 4720308 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR00238; KamA family protein complement(4719280..4720308) Escherichia coli SMS-3-5 6144580 YP_001746543.1 CDS efp NC_010498.1 4720350 4720916 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4720350..4720916 Escherichia coli SMS-3-5 6143935 YP_001746544.1 CDS ecnA NC_010498.1 4720968 4721093 D acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4720968..4721093 Escherichia coli SMS-3-5 6145639 YP_001746545.1 CDS ecnB NC_010498.1 4721204 4721350 D identified by similarity to SP:P0ADB7; match to protein family HMM PF08085; entericidin B membrane lipoprotein 4721204..4721350 Escherichia coli SMS-3-5 6143449 YP_001746546.1 CDS sugE NC_010498.1 4721525 4721842 D member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4721525..4721842 Escherichia coli SMS-3-5 6146597 YP_001746547.1 CDS blc NC_010498.1 4721839 4722372 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4721839..4722372) Escherichia coli SMS-3-5 6146756 YP_001746548.1 CDS ampC NC_010498.1 4722460 4723593 R identified by match to protein family HMM PF00144; beta-lactamase complement(4722460..4723593) Escherichia coli SMS-3-5 6147308 YP_001746549.1 CDS frdD NC_010498.1 4723656 4724015 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4723656..4724015) Escherichia coli SMS-3-5 6145399 YP_001746550.1 CDS frdC NC_010498.1 4724026 4724421 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(4724026..4724421) Escherichia coli SMS-3-5 6145709 YP_001746551.1 CDS frdB NC_010498.1 4724432 4725166 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(4724432..4725166) Escherichia coli SMS-3-5 6144023 YP_001746552.1 CDS frdA NC_010498.1 4725159 4726967 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(4725159..4726967) Escherichia coli SMS-3-5 6143920 YP_001746553.1 CDS genX NC_010498.1 4727292 4728269 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4727292..4728269 Escherichia coli SMS-3-5 6144552 YP_001746554.1 CDS EcSMS35_4627 NC_010498.1 4728446 4729990 D identified by match to protein family HMM PF00324; amino acid permease family protein 4728446..4729990 Escherichia coli SMS-3-5 6143335 YP_001746555.1 CDS EcSMS35_4628 NC_010498.1 4730053 4730367 D identified by Glimmer3; putative; hypothetical protein 4730053..4730367 Escherichia coli SMS-3-5 6144490 YP_001746556.1 CDS EcSMS35_4629 NC_010498.1 4730376 4730678 D identified by similarity to SP:P39284; hypothetical protein 4730376..4730678 Escherichia coli SMS-3-5 6142823 YP_001746557.1 CDS EcSMS35_4630 NC_010498.1 4730709 4734032 R identified by match to protein family HMM PF00924; hypothetical protein complement(4730709..4734032) Escherichia coli SMS-3-5 6143377 YP_001746558.1 CDS psd NC_010498.1 4734054 4735022 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(4734054..4735022) Escherichia coli SMS-3-5 6146767 YP_001746559.1 CDS rsgA NC_010498.1 4735118 4736170 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(4735118..4736170) Escherichia coli SMS-3-5 6147202 YP_001746560.1 CDS orn NC_010498.1 4736265 4736810 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4736265..4736810 Escherichia coli SMS-3-5 6145670 YP_001746561.1 CDS EcSMS35_4637 NC_010498.1 4737710 4738849 R identified by match to protein family HMM PF00037; match to protein family HMM PF08331; match to protein family HMM TIGR00276; iron-sulfur cluster binding protein complement(4737710..4738849) Escherichia coli SMS-3-5 6143627 YP_001746562.1 CDS EcSMS35_4638 NC_010498.1 4738863 4740395 D identified by match to protein family HMM PF01256; match to protein family HMM PF03853; match to protein family HMM TIGR00196; match to protein family HMM TIGR00197; hypothetical protein 4738863..4740395 Escherichia coli SMS-3-5 6144675 YP_001746563.1 CDS EcSMS35_4639 NC_010498.1 4740370 4740828 D possibly involved in cell wall synthesis; putative ATPase 4740370..4740828 Escherichia coli SMS-3-5 6145171 YP_001746564.1 CDS amiB NC_010498.1 4740847 4742184 D identified by similarity to SP:P26365; match to protein family HMM PF01520; N-acetylmuramoyl-l-alanine amidase II 4740847..4742184 Escherichia coli SMS-3-5 6143598 YP_001746565.1 CDS mutL NC_010498.1 4742194 4744041 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4742194..4744041 Escherichia coli SMS-3-5 6144684 YP_001746566.1 CDS miaA NC_010498.1 4744034 4744984 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4744034..4744984 Escherichia coli SMS-3-5 6145448 YP_001746567.1 CDS hfq NC_010498.1 4745070 4745378 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4745070..4745378 Escherichia coli SMS-3-5 6146097 YP_001746568.1 CDS hflX NC_010498.1 4745454 4746734 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4745454..4746734 Escherichia coli SMS-3-5 6145417 YP_001746569.1 CDS hflK NC_010498.1 4746820 4748079 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4746820..4748079 Escherichia coli SMS-3-5 6146160 YP_001746570.1 CDS hflC NC_010498.1 4748082 4749086 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4748082..4749086 Escherichia coli SMS-3-5 6146834 YP_001746571.1 CDS EcSMS35_4647 NC_010498.1 4749168 4749365 D hypothetical protein 4749168..4749365 Escherichia coli SMS-3-5 6147522 YP_001746572.1 CDS purA NC_010498.1 4749469 4750767 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4749469..4750767 Escherichia coli SMS-3-5 6143254 YP_001746573.1 CDS nsrR NC_010498.1 4750972 4751397 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4750972..4751397 Escherichia coli SMS-3-5 6144041 YP_001746574.1 CDS rnr NC_010498.1 4751436 4753877 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4751436..4753877 Escherichia coli SMS-3-5 6144921 YP_001746575.1 CDS EcSMS35_4651 NC_010498.1 4754058 4754789 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4754058..4754789 Escherichia coli SMS-3-5 6145781 YP_001746576.1 CDS EcSMS35_4652 NC_010498.1 4754916 4755317 D hypothetical protein 4754916..4755317 Escherichia coli SMS-3-5 6143734 YP_001746577.1 CDS EcSMS35_4653 NC_010498.1 4755336 4756034 D identified by match to protein family HMM PF04012; PspA/IM30 family protein 4755336..4756034 Escherichia coli SMS-3-5 6144443 YP_001746578.1 CDS EcSMS35_4654 NC_010498.1 4756084 4756743 D hypothetical protein 4756084..4756743 Escherichia coli SMS-3-5 6146156 YP_001746579.1 CDS EcSMS35_4655 NC_010498.1 4756761 4757159 D identified by match to protein family HMM PF03994; putative inner membrane protein 4756761..4757159 Escherichia coli SMS-3-5 6146814 YP_001746580.1 CDS EcSMS35_4656 NC_010498.1 4757169 4757807 D identified by match to protein family HMM PF06693; hypothetical protein 4757169..4757807 Escherichia coli SMS-3-5 6145413 YP_001746581.1 CDS EcSMS35_4657 NC_010498.1 4757810 4758973 D identified by match to protein family HMM PF03738; glutathionylspermidine synthase domain-containing protein 4757810..4758973 Escherichia coli SMS-3-5 6146112 YP_001746582.1 CDS EcSMS35_4658 NC_010498.1 4759057 4760682 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4759057..4760682 Escherichia coli SMS-3-5 6144078 YP_001746583.1 CDS EcSMS35_4659 NC_010498.1 4760799 4761086 R identified by match to protein family HMM PF07338; hypothetical protein complement(4760799..4761086) Escherichia coli SMS-3-5 6144710 YP_001746584.1 CDS EcSMS35_4660 NC_010498.1 4761223 4761552 R in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A complement(4761223..4761552) Escherichia coli SMS-3-5 6144576 YP_001746585.1 CDS EcSMS35_4662 NC_010498.1 4761734 4762483 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4761734..4762483 Escherichia coli SMS-3-5 6146933 YP_001746586.1 CDS ulaR NC_010498.1 4762480 4763235 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4762480..4763235) Escherichia coli SMS-3-5 6146638 YP_001746587.1 CDS EcSMS35_4663 NC_010498.1 4763343 4764407 R putative L-ascorbate 6-phosphate lactonase complement(4763343..4764407) Escherichia coli SMS-3-5 6145134 YP_001746588.1 CDS ulaA NC_010498.1 4764762 4766159 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4764762..4766159 Escherichia coli SMS-3-5 6147065 YP_001746589.1 CDS ulaB NC_010498.1 4766175 4766480 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4766175..4766480 Escherichia coli SMS-3-5 6144381 YP_001746590.1 CDS ulaC NC_010498.1 4766490 4766954 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4766490..4766954 Escherichia coli SMS-3-5 6143461 YP_001746591.1 CDS ulaD NC_010498.1 4766968 4767618 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4766968..4767618 Escherichia coli SMS-3-5 6143754 YP_001746592.1 CDS ulaE NC_010498.1 4767628 4768482 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4767628..4768482 Escherichia coli SMS-3-5 6144398 YP_001746593.1 CDS sgaE NC_010498.1 4768482 4769168 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4768482..4769168 Escherichia coli SMS-3-5 6145109 YP_001746594.1 CDS EcSMS35_4670 NC_010498.1 4769297 4769572 R identified by match to protein family HMM PF07338; hypothetical protein complement(4769297..4769572) Escherichia coli SMS-3-5 6145665 YP_001746595.1 CDS rpsF NC_010498.1 4769900 4770295 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4769900..4770295 Escherichia coli SMS-3-5 6143107 YP_001746596.1 CDS rpsR NC_010498.1 4770621 4770848 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4770621..4770848 Escherichia coli SMS-3-5 6146646 YP_001746597.1 CDS rplI NC_010498.1 4770890 4771339 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4770890..4771339 Escherichia coli SMS-3-5 6144183 YP_001746598.1 CDS EcSMS35_4674 NC_010498.1 4771451 4772422 R identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein complement(4771451..4772422) Escherichia coli SMS-3-5 6144848 YP_001746599.1 CDS EcSMS35_4675 NC_010498.1 4772475 4773776 R identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter, DctM subunit complement(4772475..4773776) Escherichia coli SMS-3-5 6145560 YP_001746600.1 CDS EcSMS35_4676 NC_010498.1 4773819 4774295 R identified by match to protein family HMM PF04290; TRAP transporter, DctQ-like membrane protein complement(4773819..4774295) Escherichia coli SMS-3-5 6144007 YP_001746601.1 CDS EcSMS35_4677 NC_010498.1 4774316 4776397 R identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF07992; pyridine nucleotide-disulphide oxidoreductase complement(4774316..4776397) Escherichia coli SMS-3-5 6145083 YP_001746602.1 CDS EcSMS35_4678 NC_010498.1 4776394 4777935 R identified by match to protein family HMM PF01144; CoA-transferase complement(4776394..4777935) Escherichia coli SMS-3-5 6145723 YP_001746603.1 CDS EcSMS35_4679 NC_010498.1 4777945 4778721 R identified by match to protein family HMM PF00378; enoyl-CoA hydratase/isomerase family protein complement(4777945..4778721) Escherichia coli SMS-3-5 6143301 YP_001746604.1 CDS EcSMS35_4680 NC_010498.1 4778731 4779573 R identified by match to protein family HMM PF01261; AP endonuclease complement(4778731..4779573) Escherichia coli SMS-3-5 6146640 YP_001746605.1 CDS EcSMS35_4681 NC_010498.1 4779583 4780374 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase complement(4779583..4780374) Escherichia coli SMS-3-5 6145818 YP_001746606.1 CDS EcSMS35_4682 NC_010498.1 4780584 4781222 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 4780584..4781222 Escherichia coli SMS-3-5 6144208 YP_001746607.1 CDS EcSMS35_4683 NC_010498.1 4781223 4781852 R identified by match to protein family HMM PF04225; match to protein family HMM PF08525; opacity-associated family protein complement(4781223..4781852) Escherichia coli SMS-3-5 6145328 YP_001746608.1 CDS fklB NC_010498.1 4782070 4782690 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4782070..4782690 Escherichia coli SMS-3-5 6145927 YP_001746609.1 CDS cycA NC_010498.1 4782999 4784402 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4782999..4784402 Escherichia coli SMS-3-5 6146330 YP_001746610.1 CDS EcSMS35_4686 NC_010498.1 4784536 4785693 D identified by similarity to GB:CAD06876.1; hypothetical protein 4784536..4785693 Escherichia coli SMS-3-5 6147003 YP_001746611.1 CDS EcSMS35_4687 NC_010498.1 4785726 4787219 D identified by similarity to GB:CAD06877.1; hypothetical protein 4785726..4787219 Escherichia coli SMS-3-5 6143275 YP_001746612.1 CDS EcSMS35_4688 NC_010498.1 4787264 4787926 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(4787264..4787926) Escherichia coli SMS-3-5 6146196 YP_001746613.1 CDS EcSMS35_4689 NC_010498.1 4788034 4788999 R identified by match to protein family HMM PF00892; hypothetical protein complement(4788034..4788999) Escherichia coli SMS-3-5 6144451 YP_001746614.1 CDS EcSMS35_4690 NC_010498.1 4789107 4789967 R identified by match to protein family HMM PF01073; match to protein family HMM PF05368; NmrA family protein complement(4789107..4789967) Escherichia coli SMS-3-5 6144764 YP_001746615.1 CDS EcSMS35_4691 NC_010498.1 4790056 4790436 D identified by match to protein family HMM PF01638; putative transcriptional regulator 4790056..4790436 Escherichia coli SMS-3-5 6147237 YP_001746616.1 CDS cpdB NC_010498.1 4790565 4792508 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein complement(4790565..4792508) Escherichia coli SMS-3-5 6145344 YP_001746617.1 CDS cysQ NC_010498.1 4792698 4793438 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4792698..4793438 Escherichia coli SMS-3-5 6143037 YP_001746618.1 CDS EcSMS35_4693 NC_010498.1 4793428 4793985 R identified by match to protein family HMM TIGR01626; hypothetical protein complement(4793428..4793985) Escherichia coli SMS-3-5 6144479 YP_001746619.1 CDS EcSMS35_4695 NC_010498.1 4794310 4794516 D identified by match to protein family HMM PF06526; hypothetical protein 4794310..4794516 Escherichia coli SMS-3-5 6146705 YP_001746620.1 CDS EcSMS35_4696 NC_010498.1 4794578 4795921 R identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; putative transporter complement(4794578..4795921) Escherichia coli SMS-3-5 6147406 YP_001746621.1 CDS msrA NC_010498.1 4796244 4796882 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(4796244..4796882) Escherichia coli SMS-3-5 6144053 YP_001746622.1 CDS EcSMS35_4698 NC_010498.1 4796990 4797118 D identified by Glimmer3; putative; hypothetical protein 4796990..4797118 Escherichia coli SMS-3-5 6143988 YP_001746623.1 CDS EcSMS35_4699 NC_010498.1 4797088 4798821 D identified by match to protein family HMM PF01103; match to protein family HMM PF07244; OMP85 family outer membrane protein 4797088..4798821 Escherichia coli SMS-3-5 6145439 YP_001746624.1 CDS EcSMS35_4700 NC_010498.1 4798818 4802597 D identified by match to protein family HMM PF04357; hypothetical protein 4798818..4802597 Escherichia coli SMS-3-5 6145884 YP_001746625.1 CDS EcSMS35_4701 NC_010498.1 4802600 4802941 D identified by match to protein family HMM PF03674; hypothetical protein 4802600..4802941 Escherichia coli SMS-3-5 6147503 YP_001746626.1 CDS chpS NC_010498.1 4803153 4803404 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4803153..4803404 Escherichia coli SMS-3-5 6147151 YP_001746627.1 CDS chpB NC_010498.1 4803398 4803748 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4803398..4803748 Escherichia coli SMS-3-5 6144066 YP_001746628.1 CDS ppa NC_010498.1 4803827 4804357 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(4803827..4804357) Escherichia coli SMS-3-5 6143499 YP_001746629.1 CDS EcSMS35_4705 NC_010498.1 4804667 4805623 D identified by match to protein family HMM PF00532; putative sugar ABC transporter periplasmic sugar-binding protein 4804667..4805623 Escherichia coli SMS-3-5 6144410 YP_001746630.1 CDS EcSMS35_4706 NC_010498.1 4805756 4807258 D identified by match to protein family HMM PF00005; putative sugar ABC transporter ATP-binding protein 4805756..4807258 Escherichia coli SMS-3-5 6143827 YP_001746631.1 CDS EcSMS35_4707 NC_010498.1 4807272 4808294 D identified by match to protein family HMM PF02653; putative sugar ABC transporter permease 4807272..4808294 Escherichia coli SMS-3-5 6145528 YP_001746632.1 CDS EcSMS35_4708 NC_010498.1 4808281 4809276 D membrane component of a putative sugar ABC transporter system; inner membrane ABC transporter permease YjfF 4808281..4809276 Escherichia coli SMS-3-5 6145178 YP_001746633.1 CDS fbp NC_010498.1 4809309 4810307 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(4809309..4810307) Escherichia coli SMS-3-5 6146901 YP_001746634.1 CDS EcSMS35_4710 NC_010498.1 4810370 4810501 D hypothetical protein 4810370..4810501 Escherichia coli SMS-3-5 6146470 YP_001746635.1 CDS mpl NC_010498.1 4810483 4811856 D identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01081; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4810483..4811856 Escherichia coli SMS-3-5 6146027 YP_001746636.1 CDS yjgA NC_010498.1 4811939 4812490 R yjgA; identified by match to protein family HMM PF04751; hypothetical protein complement(4811939..4812490) Escherichia coli SMS-3-5 6145218 YP_001746637.1 CDS pmbA NC_010498.1 4812584 4813936 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4812584..4813936 Escherichia coli SMS-3-5 6144813 YP_001746638.1 CDS cybC NC_010498.1 4813992 4814378 D identified by match to protein family HMM PF07361; soluble cytochrome b562 4813992..4814378 Escherichia coli SMS-3-5 6145615 YP_001746639.1 CDS relB NC_010498.1 4814570 4814812 D Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 4814570..4814812 Escherichia coli SMS-3-5 6147356 YP_001746640.1 CDS relE NC_010498.1 4814802 4815092 D identified by similarity to SP:P0C077; match to protein family HMM PF05016; match to protein family HMM TIGR02385; addiction module toxin RelE 4814802..4815092 Escherichia coli SMS-3-5 6144558 YP_001746641.1 CDS nrdG NC_010498.1 4815093 4815557 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(4815093..4815557) Escherichia coli SMS-3-5 6146600 YP_001746642.1 CDS nrdD NC_010498.1 4815742 4817880 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(4815742..4817880) Escherichia coli SMS-3-5 6143559 YP_001746643.1 CDS EcSMS35_4719 NC_010498.1 4817920 4818042 D identified by Glimmer3; putative; hypothetical protein 4817920..4818042 Escherichia coli SMS-3-5 6145464 YP_001746644.1 CDS treC NC_010498.1 4818274 4819929 R identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; trehalose-6-phosphate hydrolase complement(4818274..4819929) Escherichia coli SMS-3-5 6147116 YP_001746645.1 CDS treB NC_010498.1 4819979 4821400 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC complement(4819979..4821400) Escherichia coli SMS-3-5 6146907 YP_001746646.1 CDS treR NC_010498.1 4821519 4822466 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(4821519..4822466) Escherichia coli SMS-3-5 6147153 YP_001746647.1 CDS mgtA NC_010498.1 4822845 4825541 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4822845..4825541 Escherichia coli SMS-3-5 6144743 YP_001746648.1 CDS EcSMS35_4724 NC_010498.1 4825747 4826172 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; putative endoribonuclease L-PSP complement(4825747..4826172) Escherichia coli SMS-3-5 6142916 YP_001746649.1 CDS pyrI NC_010498.1 4826206 4826667 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit complement(4826206..4826667) Escherichia coli SMS-3-5 6143425 YP_001746650.1 CDS pyrB NC_010498.1 4826680 4827615 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(4826680..4827615) Escherichia coli SMS-3-5 6146493 YP_001746651.1 CDS EcSMS35_4727 NC_010498.1 4827786 4827929 R identified by Glimmer3; putative; hypothetical protein complement(4827786..4827929) Escherichia coli SMS-3-5 6145120 YP_001746652.1 CDS EcSMS35_4728 NC_010498.1 4828034 4828429 R identified by match to protein family HMM PF01042; endoribonuclease L-PSP family protein complement(4828034..4828429) Escherichia coli SMS-3-5 6145265 YP_001746653.1 CDS EcSMS35_4729 NC_010498.1 4828561 4829274 R identified by match to protein family HMM PF00106; oxidoreductase complement(4828561..4829274) Escherichia coli SMS-3-5 6143750 YP_001746654.1 CDS EcSMS35_4730 NC_010498.1 4829345 4829938 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 4829345..4829938 Escherichia coli SMS-3-5 6144525 YP_001746655.1 CDS EcSMS35_4731 NC_010498.1 4829938 4830066 D identified by Glimmer3; putative; hypothetical protein 4829938..4830066 Escherichia coli SMS-3-5 6147262 YP_001746656.1 CDS EcSMS35_4732 NC_010498.1 4830083 4830535 D yjgK; identified by similarity to SP:P0AF97; match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 4830083..4830535 Escherichia coli SMS-3-5 6145372 YP_001746657.1 CDS argF NC_010498.1 4832383 4833387 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I complement(4832383..4833387) Escherichia coli SMS-3-5 6144756 YP_001746658.1 CDS EcSMS35_4735 NC_010498.1 4833549 4833965 D identified by match to protein family HMM PF06877; hypothetical protein 4833549..4833965 Escherichia coli SMS-3-5 6147462 YP_001746659.1 CDS EcSMS35_4736 NC_010498.1 4834011 4834514 R identified by match to protein family HMM PF00583; acetyltransferase complement(4834011..4834514) Escherichia coli SMS-3-5 6142708 YP_001746660.1 CDS EcSMS35_4737 NC_010498.1 4834680 4835903 D identified by match to protein family HMM PF05987; hypothetical protein 4834680..4835903 Escherichia coli SMS-3-5 6143414 YP_001746661.1 CDS valS NC_010498.1 4835957 4838812 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(4835957..4838812) Escherichia coli SMS-3-5 6146645 YP_001746662.1 CDS holC NC_010498.1 4838812 4839294 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(4838812..4839294) Escherichia coli SMS-3-5 6147270 YP_001746663.1 CDS pepA NC_010498.1 4839389 4840900 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(4839389..4840900) Escherichia coli SMS-3-5 6147238 YP_001746664.1 CDS EcSMS35_4741 NC_010498.1 4841125 4841253 R identified by Glimmer3; putative; hypothetical protein complement(4841125..4841253) Escherichia coli SMS-3-5 6146175 YP_001746665.1 CDS EcSMS35_4742 NC_010498.1 4841167 4842267 D identified by match to protein family HMM PF03739; putative permease 4841167..4842267 Escherichia coli SMS-3-5 6146358 YP_001746666.1 CDS EcSMS35_4743 NC_010498.1 4842267 4843349 D identified by match to protein family HMM PF03739; putative permease 4842267..4843349 Escherichia coli SMS-3-5 6145706 YP_001746667.1 CDS EcSMS35_4744 NC_010498.1 4843468 4844970 R identified by match to protein family HMM PF05872; hypothetical protein complement(4843468..4844970) Escherichia coli SMS-3-5 6145960 YP_001746668.1 CDS idnR NC_010498.1 4845048 4846046 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator IdnR complement(4845048..4846046) Escherichia coli SMS-3-5 6145270 YP_001746669.1 CDS idnT NC_010498.1 4846113 4847432 R identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM PF06808; match to protein family HMM TIGR00791; Gnt-II system L-idonate transporter complement(4846113..4847432) Escherichia coli SMS-3-5 6144098 YP_001746670.1 CDS idnO NC_010498.1 4847497 4848261 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(4847497..4848261) Escherichia coli SMS-3-5 6143606 YP_001746671.1 CDS idnD NC_010498.1 4848285 4849316 R NAD-binding; L-idonate 5-dehydrogenase complement(4848285..4849316) Escherichia coli SMS-3-5 6142906 YP_001746672.1 CDS idnK NC_010498.1 4849533 4850096 D identified by match to protein family HMM PF01202; match to protein family HMM TIGR01313; D-gluconate kinase 4849533..4850096 Escherichia coli SMS-3-5 6147245 YP_001746673.1 CDS EcSMS35_4750 NC_010498.1 4850100 4851119 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase complement(4850100..4851119) Escherichia coli SMS-3-5 6143165 YP_001746674.1 CDS EcSMS35_4753 NC_010498.1 4851586 4852851 D identified by match to protein family HMM PF00589; phage integrase family site specific recombinase 4851586..4852851 Escherichia coli SMS-3-5 6143639 YP_001746675.1 CDS EcSMS35_4754 NC_010498.1 4853175 4854674 R yjgX; identified by match to protein family HMM PF00884; sulfatase family protein complement(4853175..4854674) Escherichia coli SMS-3-5 6146721 YP_001746676.1 CDS EcSMS35_4755 NC_010498.1 4854848 4855639 R identified by similarity to GB:AAC13751.1; match to protein family HMM PF01389; match to protein family HMM PF01617; heat resistant agglutinin 1 complement(4854848..4855639) Escherichia coli SMS-3-5 6145486 YP_001746677.1 CDS EcSMS35_4757 NC_010498.1 4856011 4856514 R identified by match to protein family HMM PF03400; IS1 transposase orfB complement(4856011..4856514) Escherichia coli SMS-3-5 6144163 YP_001746678.1 CDS EcSMS35_4758 NC_010498.1 4856525 4856737 R IS1 transposase orfA complement(4856525..4856737) Escherichia coli SMS-3-5 6143218 YP_001746679.1 CDS EcSMS35_4759 NC_010498.1 4856981 4857478 D identified by match to protein family HMM PF04221; addiction module antitoxin 4856981..4857478 Escherichia coli SMS-3-5 6143555 YP_001746680.1 CDS EcSMS35_4760 NC_010498.1 4857545 4859524 D identified by match to protein family HMM PF02384; type I restriction-modification system DNA methylase 4857545..4859524 Escherichia coli SMS-3-5 6144043 YP_001746681.1 CDS EcSMS35_4761 NC_010498.1 4859524 4860810 D identified by match to protein family HMM PF01420; type I restriction modification DNA specificity domain-containing protein 4859524..4860810 Escherichia coli SMS-3-5 6147429 YP_001746682.1 CDS EcSMS35_4762 NC_010498.1 4860810 4864046 D identified by match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system endonuclease 4860810..4864046 Escherichia coli SMS-3-5 6144539 YP_001746683.1 CDS EcSMS35_4763 NC_010498.1 4864046 4864600 D identified by similarity to GB:AAW89424.1; hypothetical protein 4864046..4864600 Escherichia coli SMS-3-5 6146781 YP_001746684.1 CDS EcSMS35_4764 NC_010498.1 4864603 4865442 D identified by similarity to GB:AAW89425.1; hypothetical protein 4864603..4865442 Escherichia coli SMS-3-5 6146243 YP_001746685.1 CDS EcSMS35_4765 NC_010498.1 4865478 4866512 D identified by similarity to GB:AAL22613.1; hypothetical protein 4865478..4866512 Escherichia coli SMS-3-5 6145916 YP_001746686.1 CDS EcSMS35_4766 NC_010498.1 4866570 4866956 R identified by Glimmer3; putative; hypothetical protein complement(4866570..4866956) Escherichia coli SMS-3-5 6144923 YP_001746687.1 CDS EcSMS35_4767 NC_010498.1 4867046 4867246 R identified by Glimmer3; putative; hypothetical protein complement(4867046..4867246) Escherichia coli SMS-3-5 6145189 YP_001746688.1 CDS EcSMS35_4768 NC_010498.1 4867751 4868083 D identified by Glimmer3; putative; hypothetical protein 4867751..4868083 Escherichia coli SMS-3-5 6145635 YP_001746689.1 CDS EcSMS35_4770 NC_010498.1 4869080 4869703 R identified by similarity to GB:AAT68662.1; hypothetical protein complement(4869080..4869703) Escherichia coli SMS-3-5 6142705 YP_001746690.1 CDS EcSMS35_4771 NC_010498.1 4869886 4870776 R identified by match to protein family HMM PF00665; IS1203 transposase orfB complement(4869886..4870776) Escherichia coli SMS-3-5 6143978 YP_001746691.1 CDS EcSMS35_4772 NC_010498.1 4870757 4871098 R identified by match to protein family HMM PF01527; IS1203 transposase orfA complement(4870757..4871098) Escherichia coli SMS-3-5 6144340 YP_001746692.1 CDS EcSMS35_4773 NC_010498.1 4871104 4871403 R identified by Glimmer3; putative; hypothetical protein complement(4871104..4871403) Escherichia coli SMS-3-5 6142794 YP_001746693.1 CDS EcSMS35_4775 NC_010498.1 4871735 4872100 R hypothetical protein complement(4871735..4872100) Escherichia coli SMS-3-5 6147013 YP_001746694.1 CDS EcSMS35_4777 NC_010498.1 4872207 4873415 D identified by match to protein family HMM PF01609; IS10 transposase 4872207..4873415 Escherichia coli SMS-3-5 6146669 YP_001746695.1 CDS EcSMS35_4776 NC_010498.1 4873394 4874056 R identified by similarity to GB:AAM31897.1; hypothetical protein complement(4873394..4874056) Escherichia coli SMS-3-5 6146697 YP_001746696.1 CDS EcSMS35_4778 NC_010498.1 4874066 4874674 R identified by similarity to GB:ABE29579.1; hypothetical protein complement(4874066..4874674) Escherichia coli SMS-3-5 6147204 YP_001746697.1 CDS EcSMS35_4780 NC_010498.1 4875264 4875776 R identified by Glimmer3; putative; hypothetical protein complement(4875264..4875776) Escherichia coli SMS-3-5 6143278 YP_001746698.1 CDS EcSMS35_4781 NC_010498.1 4875858 4875995 R identified by Glimmer3; putative; hypothetical protein complement(4875858..4875995) Escherichia coli SMS-3-5 6144326 YP_001746699.1 CDS EcSMS35_4782 NC_010498.1 4876033 4876266 R identified by match to protein family HMM PF05930; AlpA family transcriptional regulator complement(4876033..4876266) Escherichia coli SMS-3-5 6147216 YP_001746700.1 CDS EcSMS35_4783 NC_010498.1 4876335 4876910 R identified by Glimmer3; putative; hypothetical protein complement(4876335..4876910) Escherichia coli SMS-3-5 6144290 YP_001746701.1 CDS EcSMS35_4784 NC_010498.1 4877157 4877723 R identified by similarity to GB:CAG75762.1; hypothetical protein complement(4877157..4877723) Escherichia coli SMS-3-5 6143360 YP_001746702.1 CDS EcSMS35_4786 NC_010498.1 4879662 4880102 R identified by match to protein family HMM PF00816; H-NS histone family protein complement(4879662..4880102) Escherichia coli SMS-3-5 6147488 YP_001746703.1 CDS EcSMS35_4789 NC_010498.1 4881859 4882557 R identified by similarity to GB:ABB74995.1; hypothetical protein complement(4881859..4882557) Escherichia coli SMS-3-5 6143468 YP_001746704.1 CDS EcSMS35_4790 NC_010498.1 4882614 4882940 D IS1203 transposase orfA 4882614..4882940 Escherichia coli SMS-3-5 6142760 YP_001746705.1 CDS EcSMS35_4791 NC_010498.1 4882937 4883827 D identified by match to protein family HMM PF00665; IS1203 transposase orfB 4882937..4883827 Escherichia coli SMS-3-5 6144051 YP_001746706.1 CDS EcSMS35_4792 NC_010498.1 4884268 4884381 R identified by Glimmer3; putative; hypothetical protein complement(4884268..4884381) Escherichia coli SMS-3-5 6143984 YP_001746707.1 CDS EcSMS35_4793 NC_010498.1 4884378 4885109 R hypothetical protein complement(4884378..4885109) Escherichia coli SMS-3-5 6145641 YP_001746708.1 CDS EcSMS35_4794 NC_010498.1 4885293 4885445 D identified by Glimmer3; putative; hypothetical protein 4885293..4885445 Escherichia coli SMS-3-5 6144992 YP_001746709.1 CDS EcSMS35_4795 NC_010498.1 4886588 4887718 R identified by Glimmer3; putative; hypothetical protein complement(4886588..4887718) Escherichia coli SMS-3-5 6145202 YP_001746710.1 CDS EcSMS35_4796 NC_010498.1 4887775 4887909 R identified by Glimmer3; putative; hypothetical protein complement(4887775..4887909) Escherichia coli SMS-3-5 6144383 YP_001746711.1 CDS EcSMS35_4797 NC_010498.1 4887903 4888787 D identified by match to protein family HMM PF01926; putative GTPase 4887903..4888787 Escherichia coli SMS-3-5 6146158 YP_001746712.1 CDS EcSMS35_4798 NC_010498.1 4888806 4888961 D identified by Glimmer3; putative; hypothetical protein 4888806..4888961 Escherichia coli SMS-3-5 6144113 YP_001746713.1 CDS EcSMS35_4799 NC_010498.1 4888990 4889670 D identified by match to protein family HMM PF08279; hypothetical protein 4888990..4889670 Escherichia coli SMS-3-5 6145997 YP_001746714.1 CDS EcSMS35_4800 NC_010498.1 4889713 4890495 D identified by Glimmer3; putative; hypothetical protein 4889713..4890495 Escherichia coli SMS-3-5 6145394 YP_001746715.1 CDS EcSMS35_4801 NC_010498.1 4890585 4890734 D hypothetical protein 4890585..4890734 Escherichia coli SMS-3-5 6146275 YP_001746716.1 CDS EcSMS35_4802 NC_010498.1 4890824 4891642 D yafZ; identified by match to protein family HMM PF06067; hypothetical protein 4890824..4891642 Escherichia coli SMS-3-5 6145624 YP_001746717.1 CDS EcSMS35_4803 NC_010498.1 4891734 4892219 D identified by match to protein family HMM PF03230; antirestriction protein 4891734..4892219 Escherichia coli SMS-3-5 6142695 YP_001746718.1 CDS EcSMS35_4804 NC_010498.1 4892234 4892710 D identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; RadC family DNA repair protein 4892234..4892710 Escherichia coli SMS-3-5 6147010 YP_001746719.1 CDS EcSMS35_4805 NC_010498.1 4892797 4893018 D identified by match to protein family HMM PF06174; hypothetical protein 4892797..4893018 Escherichia coli SMS-3-5 6144854 YP_001746720.1 CDS EcSMS35_4806 NC_010498.1 4893218 4893466 D identified by match to protein family HMM PF06154; hypothetical protein 4893218..4893466 Escherichia coli SMS-3-5 6144920 YP_001746721.1 CDS EcSMS35_4807 NC_010498.1 4893556 4893933 D identified by match to protein family HMM PF06755; hypothetical protein 4893556..4893933 Escherichia coli SMS-3-5 6145839 YP_001746722.1 CDS EcSMS35_4808 NC_010498.1 4893930 4894418 D hypothetical protein 4893930..4894418 Escherichia coli SMS-3-5 6147484 YP_001746723.1 CDS EcSMS35_4809 NC_010498.1 4894438 4894635 D identified by match to protein family HMM PF06117; hypothetical protein 4894438..4894635 Escherichia coli SMS-3-5 6144724 YP_001746724.1 CDS EcSMS35_4812 NC_010498.1 4896629 4897522 R hypothetical protein complement(4896629..4897522) Escherichia coli SMS-3-5 6145958 YP_001746725.1 CDS EcSMS35_4813 NC_010498.1 4897698 4899164 D identified by Glimmer3; putative; hypothetical protein 4897698..4899164 Escherichia coli SMS-3-5 6146728 YP_001746726.1 CDS EcSMS35_4814 NC_010498.1 4899167 4900063 D identified by Glimmer3; putative; hypothetical protein 4899167..4900063 Escherichia coli SMS-3-5 6147293 YP_001746727.1 CDS EcSMS35_4815 NC_010498.1 4900066 4904502 D identified by Glimmer3; putative; hypothetical protein 4900066..4904502 Escherichia coli SMS-3-5 6142792 YP_001746728.1 CDS EcSMS35_4816 NC_010498.1 4904515 4905570 D hypothetical protein 4904515..4905570 Escherichia coli SMS-3-5 6144573 YP_001746729.1 CDS EcSMS35_4817 NC_010498.1 4905697 4906695 D hypothetical protein 4905697..4906695 Escherichia coli SMS-3-5 6144102 YP_001746730.1 CDS EcSMS35_4818 NC_010498.1 4906807 4907679 R hypothetical protein complement(4906807..4907679) Escherichia coli SMS-3-5 6147316 YP_001746731.1 CDS EcSMS35_4819 NC_010498.1 4907642 4907764 D identified by Glimmer3; putative; hypothetical protein 4907642..4907764 Escherichia coli SMS-3-5 6142798 YP_001746732.1 CDS EcSMS35_4820 NC_010498.1 4907816 4908457 D identified by match to protein family HMM PF01844; HNH endonuclease domain-containing protein 4907816..4908457 Escherichia coli SMS-3-5 6143320 YP_001746733.1 CDS EcSMS35_4822 NC_010498.1 4909284 4910387 R hypothetical protein complement(4909284..4910387) Escherichia coli SMS-3-5 6145041 YP_001746734.1 CDS EcSMS35_4823 NC_010498.1 4910391 4911098 R hypothetical protein complement(4910391..4911098) Escherichia coli SMS-3-5 6145548 YP_001746735.1 CDS EcSMS35_4824 NC_010498.1 4911105 4912757 R hypothetical protein complement(4911105..4912757) Escherichia coli SMS-3-5 6144928 YP_001746736.1 CDS EcSMS35_4825 NC_010498.1 4912969 4916328 D hypothetical protein 4912969..4916328 Escherichia coli SMS-3-5 6145629 YP_001746737.1 CDS EcSMS35_4827 NC_010498.1 4916328 4922642 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD/DEAH box helicase domain-containing protein 4916328..4922642 Escherichia coli SMS-3-5 6143576 YP_001746738.1 CDS EcSMS35_4826 NC_010498.1 4922629 4922745 R identified by Glimmer3; putative; hypothetical protein complement(4922629..4922745) Escherichia coli SMS-3-5 6142603 YP_001746739.1 CDS EcSMS35_4828 NC_010498.1 4922866 4925724 D identified by match to protein family HMM PF00176; match to protein family HMM PF00271; helicase family protein 4922866..4925724 Escherichia coli SMS-3-5 6146965 YP_001746740.1 CDS EcSMS35_4829 NC_010498.1 4925727 4930649 D identified by similarity to GB:ABK43865.1; hypothetical protein 4925727..4930649 Escherichia coli SMS-3-5 6143084 YP_001746741.1 CDS EcSMS35_4830 NC_010498.1 4930649 4936990 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD/DEAH box helicase domain-containing protein 4930649..4936990 Escherichia coli SMS-3-5 6143801 YP_001746742.1 CDS EcSMS35_4831 NC_010498.1 4936987 4939101 D identified by match to protein family HMM PF00580; ATP-dependent DNA helicase UvrD 4936987..4939101 Escherichia coli SMS-3-5 6144893 YP_001746743.1 CDS EcSMS35_4832 NC_010498.1 4939615 4940265 R identified by similarity to GB:CAJ67303.1; hypothetical protein complement(4939615..4940265) Escherichia coli SMS-3-5 6145423 YP_001746744.1 CDS EcSMS35_4833 NC_010498.1 4941036 4941221 D identified by Glimmer3; putative; hypothetical protein 4941036..4941221 Escherichia coli SMS-3-5 6145925 YP_001746745.1 CDS EcSMS35_4834 NC_010498.1 4941239 4942219 R identified by match to protein family HMM PF03629; hypothetical protein complement(4941239..4942219) Escherichia coli SMS-3-5 6145715 YP_001746746.1 CDS EcSMS35_4835 NC_010498.1 4942284 4943390 R identified by match to protein family HMM PF01344; match to protein family HMM PF07646; match to protein family HMM TIGR03547; N-acetylneuraminic acid mutarotase complement(4942284..4943390) Escherichia coli SMS-3-5 6144529 YP_001746747.1 CDS nanC NC_010498.1 4943410 4944126 R identified by similarity to SP:P69856; match to protein family HMM PF06178; N-acetylneuraminic acid porin NanC complement(4943410..4944126) Escherichia coli SMS-3-5 6144646 YP_001746748.1 CDS EcSMS35_4837 NC_010498.1 4944767 4944928 R identified by Glimmer3; putative; hypothetical protein complement(4944767..4944928) Escherichia coli SMS-3-5 6145543 YP_001746749.1 CDS fimB NC_010498.1 4945581 4946183 D inversion of on/off regulator of fimA; tyrosine recombinase 4945581..4946183 Escherichia coli SMS-3-5 6145082 YP_001746750.1 CDS fimE NC_010498.1 4946661 4947257 D inversion of on/off regulator of fimA; tyrosine recombinase 4946661..4947257 Escherichia coli SMS-3-5 6145487 YP_001746751.1 CDS EcSMS35_4840 NC_010498.1 4947738 4948286 D identified by match to protein family HMM PF00419; type-1 fimbrial protein 4947738..4948286 Escherichia coli SMS-3-5 6146782 YP_001746752.1 CDS EcSMS35_4842 NC_010498.1 4948393 4948890 D identified by match to protein family HMM PF00419; type-1 fimbrial protein 4948393..4948890 Escherichia coli SMS-3-5 6146539 YP_001746753.1 CDS EcSMS35_4841 NC_010498.1 4948884 4949003 R identified by Glimmer3; putative; hypothetical protein complement(4948884..4949003) Escherichia coli SMS-3-5 6142687 YP_001746754.1 CDS fimC NC_010498.1 4949002 4949652 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; chaperone protein FimC 4949002..4949652 Escherichia coli SMS-3-5 6143435 YP_001746755.1 CDS fimD1 NC_010498.1 4949785 4952355 D identified by match to protein family HMM PF00577; outer membrane usher protein fimD 4949785..4952355 Escherichia coli SMS-3-5 6142689 YP_001746756.1 CDS fimF NC_010498.1 4952365 4952895 D identified by match to protein family HMM PF00419; fimbrial protein FimF 4952365..4952895 Escherichia coli SMS-3-5 6143878 YP_001746757.1 CDS fimG NC_010498.1 4952908 4953411 D identified by match to protein family HMM PF00419; protein fimG 4952908..4953411 Escherichia coli SMS-3-5 6146096 YP_001746758.1 CDS fimH NC_010498.1 4953431 4954333 D identified by match to protein family HMM PF00419; match to protein family HMM PF09160; protein FimH 4953431..4954333 Escherichia coli SMS-3-5 6145732 YP_001746759.1 CDS gntP NC_010498.1 4954576 4955919 R identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; fructuronate transporter complement(4954576..4955919) Escherichia coli SMS-3-5 6146146 YP_001746760.1 CDS uxuA NC_010498.1 4956259 4957443 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4956259..4957443 Escherichia coli SMS-3-5 6147201 YP_001746761.1 CDS uxuB NC_010498.1 4957524 4958984 D identified by similarity to SP:P39160; match to protein family HMM PF01232; match to protein family HMM PF08125; fructuronate reductase 4957524..4958984 Escherichia coli SMS-3-5 6147535 YP_001746762.1 CDS EcSMS35_4851 NC_010498.1 4959307 4960080 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4959307..4960080 Escherichia coli SMS-3-5 6143362 YP_001746763.1 CDS EcSMS35_4852 NC_010498.1 4960221 4961051 R hypothetical protein complement(4960221..4961051) Escherichia coli SMS-3-5 6144157 YP_001746764.1 CDS EcSMS35_4853 NC_010498.1 4961384 4961527 D identified by Glimmer3; putative; hypothetical protein 4961384..4961527 Escherichia coli SMS-3-5 6143887 YP_001746765.1 CDS EcSMS35_4854 NC_010498.1 4961623 4961757 D identified by Glimmer3; putative; hypothetical protein 4961623..4961757 Escherichia coli SMS-3-5 6145445 YP_001746766.1 CDS iraD NC_010498.1 4961723 4962106 D inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 4961723..4962106 Escherichia coli SMS-3-5 6145146 YP_001746767.1 CDS ptnE NC_010498.1 4962154 4964535 R identified by match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF03610; match to protein family HMM PF05524; match to protein family HMM TIGR01003; match to protein family HMM TIGR01417; match to protein family HMM TIGR02364; phosphoenolpyruvate-protein phosphotransferase PtnE complement(4962154..4964535) Escherichia coli SMS-3-5 6147401 YP_001746768.1 CDS ptnK NC_010498.1 4964539 4965171 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(4964539..4965171) Escherichia coli SMS-3-5 6144485 YP_001746769.1 CDS ptnC NC_010498.1 4965184 4966248 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(4965184..4966248) Escherichia coli SMS-3-5 6143529 YP_001746770.1 CDS gldA NC_010498.1 4966574 4967656 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4966574..4967656 Escherichia coli SMS-3-5 6142983 YP_001746771.1 CDS cglT NC_010498.1 4967724 4968992 D identified by similarity to GB:AAL61900.1; match to protein family HMM PF07690; major facilitator family protein CglT 4967724..4968992 Escherichia coli SMS-3-5 6147094 YP_001746772.1 CDS cglE NC_010498.1 4969010 4970374 D identified by similarity to GB:AAL61901.1; match to protein family HMM PF01266; dihydrolipoamide dehydrogenase CglE 4969010..4970374 Escherichia coli SMS-3-5 6146491 YP_001746773.1 CDS EcSMS35_4862 NC_010498.1 4970675 4972216 D identified by similarity to GB:AAL61902.1; match to protein family HMM PF02028; putative carnitine transporter CglC 4970675..4972216 Escherichia coli SMS-3-5 6145795 YP_001746774.1 CDS gcxK NC_010498.1 4972272 4973414 R identified by similarity to GB:AAL61903.1; match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase GcxK complement(4972272..4973414) Escherichia coli SMS-3-5 6146453 YP_001746775.1 CDS gcxR NC_010498.1 4973489 4974376 R identified by similarity to GB:AAL61904.1; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR01505; 2-hydroxy-3-oxopropionate reductase GcxR complement(4973489..4974376) Escherichia coli SMS-3-5 6147159 YP_001746776.1 CDS gcxI NC_010498.1 4974394 4975176 R identified by similarity to GB:AAL61906.1; match to protein family HMM PF01261; match to protein family HMM TIGR03234; hydroxypyruvate isomerase Gcxl complement(4974394..4975176) Escherichia coli SMS-3-5 6142984 YP_001746777.1 CDS gcxC NC_010498.1 4975189 4976928 R catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase complement(4975189..4976928) Escherichia coli SMS-3-5 6147418 YP_001746778.1 CDS EcSMS35_4867 NC_010498.1 4977307 4979256 D Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 4977307..4979256 Escherichia coli SMS-3-5 6146905 YP_001746779.1 CDS ibeA NC_010498.1 4979543 4980913 D identified by similarity to GB:AAL61901.1; match to protein family HMM PF01266; invasion protein IbeA 4979543..4980913 Escherichia coli SMS-3-5 6146360 YP_001746780.1 CDS ibeT NC_010498.1 4980928 4982331 D identified by similarity to GB:AAL61908.1; match to protein family HMM PF03553; match to protein family HMM TIGR00931; Na+/H+ antiporter IbeT 4980928..4982331 Escherichia coli SMS-3-5 6146920 YP_001746781.1 CDS EcSMS35_4870 NC_010498.1 4982418 4983329 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; putative DNA-binding transcriptional regulator complement(4982418..4983329) Escherichia coli SMS-3-5 6144844 YP_001746782.1 CDS iadA NC_010498.1 4983394 4984566 R identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01975; isoaspartyl dipeptidase complement(4983394..4984566) Escherichia coli SMS-3-5 6144094 YP_001746783.1 CDS EcSMS35_4872 NC_010498.1 4984579 4985040 R identified by match to protein family HMM PF07670; hypothetical protein complement(4984579..4985040) Escherichia coli SMS-3-5 6143141 YP_001746784.1 CDS EcSMS35_4873 NC_010498.1 4985037 4985720 R identified by match to protein family HMM PF07670; putative transporter complement(4985037..4985720) Escherichia coli SMS-3-5 6147389 YP_001746785.1 CDS EcSMS35_4874 NC_010498.1 4985750 4985905 D identified by Glimmer3; putative; hypothetical protein 4985750..4985905 Escherichia coli SMS-3-5 6146481 YP_001746786.1 CDS kptA NC_010498.1 4985970 4986554 D in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4985970..4986554 Escherichia coli SMS-3-5 6147072 YP_001746787.1 CDS EcSMS35_4876 NC_010498.1 4986675 4991915 R identified by match to protein family HMM PF02369; putative invasin complement(4986675..4991915) Escherichia coli SMS-3-5 6142902 YP_001746788.1 CDS EcSMS35_4877 NC_010498.1 4992126 4993304 R identified by match to protein family HMM PF06779; match to protein family HMM PF07690; major facilitator transporter complement(4992126..4993304) Escherichia coli SMS-3-5 6143466 YP_001746789.1 CDS EcSMS35_4878 NC_010498.1 4993372 4994361 R identified by match to protein family HMM PF06977; SdiA-regulated protein complement(4993372..4994361) Escherichia coli SMS-3-5 6144434 YP_001746790.1 CDS EcSMS35_4879 NC_010498.1 4994469 4996442 R identified by match to protein family HMM PF00805; pentapeptide repeat-containing protein complement(4994469..4996442) Escherichia coli SMS-3-5 6147367 YP_001746791.1 CDS EcSMS35_4880 NC_010498.1 4996764 4997030 R identified by similarity to GB:ABC78983.1; hypothetical protein complement(4996764..4997030) Escherichia coli SMS-3-5 6145751 YP_001746792.1 CDS hgdC NC_010498.1 4997027 4997794 R identified by match to protein family HMM PF01869; match to protein family HMM TIGR00241; (R)-2-hydroxyglutaryl-CoA dehydratase activator complement(4997027..4997794) Escherichia coli SMS-3-5 6144141 YP_001746793.1 CDS EcSMS35_4882 NC_010498.1 4997804 4998955 R identified by match to protein family HMM PF06050; putative 2-hydroxyglutaryl-CoA dehydratase, D-component complement(4997804..4998955) Escherichia coli SMS-3-5 6145977 YP_001746794.1 CDS EcSMS35_4883 NC_010498.1 4999070 5000350 R identified by match to protein family HMM PF04286; hypothetical protein complement(4999070..5000350) Escherichia coli SMS-3-5 6144391 YP_001746795.1 CDS mdtM NC_010498.1 5000391 5001623 R identified by match to protein family HMM PF07690; multidrug resistance protein MdtM complement(5000391..5001623) Escherichia coli SMS-3-5 6145422 YP_001746796.1 CDS EcSMS35_4885 NC_010498.1 5002090 5003046 D identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 5002090..5003046 Escherichia coli SMS-3-5 6146100 YP_001746797.1 CDS EcSMS35_4886 NC_010498.1 5003289 5004701 R identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator complement(5003289..5004701) Escherichia coli SMS-3-5 6144120 YP_001746798.1 CDS EcSMS35_4887 NC_010498.1 5004878 5005042 D identified by match to protein family HMM PF06568; hypothetical protein 5004878..5005042 Escherichia coli SMS-3-5 6145065 YP_001746799.1 CDS EcSMS35_4888 NC_010498.1 5005139 5007232 D identified by similarity to GB:CAH55816.1; match to protein family HMM PF03235; match to protein family HMM PF07510; hypothetical protein 5005139..5007232 Escherichia coli SMS-3-5 6143246 YP_001746800.1 CDS EcSMS35_4889 NC_010498.1 5007279 5007677 R involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE complement(5007279..5007677) Escherichia coli SMS-3-5 6143815 YP_001746801.1 CDS EcSMS35_4891 NC_010498.1 5008273 5010123 R identified by similarity to GB:AAW87205.1; hypothetical protein complement(5008273..5010123) Escherichia coli SMS-3-5 6142914 YP_001746802.1 CDS EcSMS35_4892 NC_010498.1 5010454 5011410 R identified by match to protein family HMM PF02492; match to protein family HMM PF07683; putative GTP-binding protein YjiA complement(5010454..5011410) Escherichia coli SMS-3-5 6142872 YP_001746803.1 CDS EcSMS35_4893 NC_010498.1 5011421 5011624 R identified by match to protein family HMM PF04328; hypothetical protein complement(5011421..5011624) Escherichia coli SMS-3-5 6145165 YP_001746804.1 CDS EcSMS35_4894 NC_010498.1 5011674 5013788 R identified by match to protein family HMM PF02554; carbon starvation family protein complement(5011674..5013788) Escherichia coli SMS-3-5 6145793 YP_001746805.1 CDS EcSMS35_4895 NC_010498.1 5014092 5015312 R identified by similarity to GB:AAD56429.1; putative D-serine ammonia-lyase complement(5014092..5015312) Escherichia coli SMS-3-5 6143763 YP_001746806.1 CDS EcSMS35_4896 NC_010498.1 5015513 5016955 D identified by similarity to SP:P72349; match to protein family HMM PF07908; match to protein family HMM PF07969; N-acyl-D-amino-acid deacylase family protein 5015513..5016955 Escherichia coli SMS-3-5 6144432 YP_001746807.1 CDS EcSMS35_4897 NC_010498.1 5016965 5017354 D yfgF; identified by match to protein family HMM PF01042; putative endoribonuclease L-PSP 5016965..5017354 Escherichia coli SMS-3-5 6142875 YP_001746808.1 CDS EcSMS35_4898 NC_010498.1 5017457 5018926 D identified by match to protein family HMM PF00474; solute/sodium symporter (SSS) family protein 5017457..5018926 Escherichia coli SMS-3-5 6143804 YP_001746809.1 CDS EcSMS35_4899 NC_010498.1 5018936 5019799 R identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator complement(5018936..5019799) Escherichia coli SMS-3-5 6146469 YP_001746810.1 CDS tsr NC_010498.1 5019981 5021645 D identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein I 5019981..5021645 Escherichia coli SMS-3-5 6147169 YP_001746811.1 CDS EcSMS35_4901 NC_010498.1 5021694 5023055 R identified by match to protein family HMM PF07690; major facilitator transporter complement(5021694..5023055) Escherichia coli SMS-3-5 6147166 YP_001746812.1 CDS EcSMS35_4902 NC_010498.1 5023270 5024184 R identified by match to protein family HMM PF07729; GntR family transcriptional regulator complement(5023270..5024184) Escherichia coli SMS-3-5 6142837 YP_001746813.1 CDS EcSMS35_4903 NC_010498.1 5024323 5025345 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase family oxidoreductase 5024323..5025345 Escherichia coli SMS-3-5 6142776 YP_001746814.1 CDS mdoB NC_010498.1 5025483 5027774 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(5025483..5027774) Escherichia coli SMS-3-5 6147481 YP_001746815.1 CDS EcSMS35_4905 NC_010498.1 5028028 5028525 R hypothetical protein complement(5028028..5028525) Escherichia coli SMS-3-5 6146666 YP_001746816.1 CDS dnaC NC_010498.1 5028571 5029308 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(5028571..5029308) Escherichia coli SMS-3-5 6147056 YP_001746817.1 CDS dnaT NC_010498.1 5029311 5029850 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(5029311..5029850) Escherichia coli SMS-3-5 6144954 YP_001746818.1 CDS EcSMS35_4908 NC_010498.1 5029957 5030424 R hypothetical protein complement(5029957..5030424) Escherichia coli SMS-3-5 6145608 YP_001746819.1 CDS EcSMS35_4909 NC_010498.1 5030421 5031245 R identified by match to protein family HMM PF06738; hypothetical protein complement(5030421..5031245) Escherichia coli SMS-3-5 6143922 YP_001746820.1 CDS EcSMS35_4910 NC_010498.1 5031269 5031403 D identified by Glimmer3; putative; hypothetical protein 5031269..5031403 Escherichia coli SMS-3-5 6144559 YP_001746821.1 CDS EcSMS35_4911 NC_010498.1 5031809 5032534 D identified by match to protein family HMM PF00196; LuxR family transcriptional regulator 5031809..5032534 Escherichia coli SMS-3-5 6146320 YP_001746822.1 CDS EcSMS35_4912 NC_010498.1 5032492 5033169 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5032492..5033169 Escherichia coli SMS-3-5 6147018 YP_001746823.1 CDS fhuF NC_010498.1 5033208 5033996 R identified by match to protein family HMM PF06276; ferric iron reductase involved in ferric hydroximate transport complement(5033208..5033996) Escherichia coli SMS-3-5 6144230 YP_001746824.1 CDS EcSMS35_4914 NC_010498.1 5034098 5034373 D identified by match to protein family HMM PF07256; hypothetical protein 5034098..5034373 Escherichia coli SMS-3-5 6144891 YP_001746825.1 CDS rsmC NC_010498.1 5035035 5036066 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(5035035..5036066) Escherichia coli SMS-3-5 6143662 YP_001746826.1 CDS holD NC_010498.1 5036169 5036582 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5036169..5036582 Escherichia coli SMS-3-5 6145895 YP_001746827.1 CDS rimI NC_010498.1 5036551 5036997 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5036551..5036997 Escherichia coli SMS-3-5 6147122 YP_001746828.1 CDS yjjG NC_010498.1 5037012 5037689 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5037012..5037689 Escherichia coli SMS-3-5 6146869 YP_001746829.1 CDS prfC NC_010498.1 5037780 5039369 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5037780..5039369 Escherichia coli SMS-3-5 6147399 YP_001746830.1 CDS osmY NC_010498.1 5039762 5040367 D identified by match to protein family HMM PF04972; periplasmic protein 5039762..5040367 Escherichia coli SMS-3-5 6143013 YP_001746831.1 CDS EcSMS35_4924 NC_010498.1 5040494 5040655 D identified by Glimmer3; putative; hypothetical protein 5040494..5040655 Escherichia coli SMS-3-5 6144320 YP_001746832.1 CDS EcSMS35_4925 NC_010498.1 5040777 5041850 D identified by match to protein family HMM PF01734; patatin family phospholipase 5040777..5041850 Escherichia coli SMS-3-5 6145001 YP_001746833.1 CDS EcSMS35_4926 NC_010498.1 5041847 5042629 D identified by match to protein family HMM PF01026; putative deoxyribonuclease YjjV 5041847..5042629 Escherichia coli SMS-3-5 6143465 YP_001746834.1 CDS EcSMS35_4927 NC_010498.1 5042659 5043522 R identified by match to protein family HMM PF04055; radical SAM domain-containing protein complement(5042659..5043522) Escherichia coli SMS-3-5 6144412 YP_001746835.1 CDS EcSMS35_4928 NC_010498.1 5043494 5045044 R hypothetical protein complement(5043494..5045044) Escherichia coli SMS-3-5 6143877 YP_001746836.1 CDS EcSMS35_4929 NC_010498.1 5045020 5045145 D hypothetical protein 5045020..5045145 Escherichia coli SMS-3-5 6145554 YP_001746837.1 CDS deoC NC_010498.1 5045302 5046081 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5045302..5046081 Escherichia coli SMS-3-5 6145690 YP_001746838.1 CDS deoA NC_010498.1 5046159 5047481 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5046159..5047481 Escherichia coli SMS-3-5 6145192 YP_001746839.1 CDS deoB NC_010498.1 5047533 5048756 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5047533..5048756 Escherichia coli SMS-3-5 6147067 YP_001746840.1 CDS deoD NC_010498.1 5048813 5049532 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5048813..5049532 Escherichia coli SMS-3-5 6146672 YP_001746841.1 CDS EcSMS35_4934 NC_010498.1 5049693 5049956 R hypothetical protein complement(5049693..5049956) Escherichia coli SMS-3-5 6144476 YP_001746842.1 CDS lplA NC_010498.1 5049988 5051004 R Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A complement(5049988..5051004) Escherichia coli SMS-3-5 6143797 YP_001746843.1 CDS EcSMS35_4936 NC_010498.1 5051032 5051676 R hypothetical protein complement(5051032..5051676) Escherichia coli SMS-3-5 6144880 YP_001746844.1 CDS serB NC_010498.1 5051782 5052750 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5051782..5052750 Escherichia coli SMS-3-5 6144234 YP_001746845.1 CDS radA NC_010498.1 5052799 5054181 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5052799..5054181 Escherichia coli SMS-3-5 6145908 YP_001746846.1 CDS nadR NC_010498.1 5054202 5055434 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5054202..5055434 Escherichia coli SMS-3-5 6145248 YP_001746847.1 CDS EcSMS35_4940 NC_010498.1 5055468 5055635 D hypothetical protein 5055468..5055635 Escherichia coli SMS-3-5 6146366 YP_001746848.1 CDS EcSMS35_4941 NC_010498.1 5055742 5057409 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(5055742..5057409) Escherichia coli SMS-3-5 6143281 YP_001746849.1 CDS EcSMS35_4942 NC_010498.1 5057383 5057511 D identified by Glimmer3; putative; hypothetical protein 5057383..5057511 Escherichia coli SMS-3-5 6142853 YP_001746850.1 CDS slt NC_010498.1 5057620 5059557 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5057620..5059557 Escherichia coli SMS-3-5 6144401 YP_001746851.1 CDS trpR NC_010498.1 5059647 5059973 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5059647..5059973 Escherichia coli SMS-3-5 6144036 YP_001746852.1 CDS EcSMS35_4944 NC_010498.1 5059967 5060491 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(5059967..5060491) Escherichia coli SMS-3-5 6143767 YP_001746853.1 CDS EcSMS35_4947 NC_010498.1 5060534 5061181 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5060534..5061181 Escherichia coli SMS-3-5 6146004 YP_001746854.1 CDS rob NC_010498.1 5061178 5062047 R identified by match to protein family HMM PF00165; match to protein family HMM PF06445; right origin-binding protein complement(5061178..5062047) Escherichia coli SMS-3-5 6145489 YP_001746855.1 CDS EcSMS35_4948 NC_010498.1 5062258 5062731 D identified by match to protein family HMM PF05981; hypothetical protein 5062258..5062731 Escherichia coli SMS-3-5 6146001 YP_001746856.1 CDS creB NC_010498.1 5062744 5063433 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5062744..5063433 Escherichia coli SMS-3-5 6147075 YP_001746857.1 CDS creC NC_010498.1 5063433 5064857 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5063433..5064857 Escherichia coli SMS-3-5 6143407 YP_001746858.1 CDS EcSMS35_4951 NC_010498.1 5064915 5066267 D identified by match to protein family HMM PF06123; hypothetical protein 5064915..5066267 Escherichia coli SMS-3-5 6142699 YP_001746859.1 CDS arcA NC_010498.1 5066326 5067042 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; two-component response regulator complement(5066326..5067042) Escherichia coli SMS-3-5 6147380 YP_001746860.1 CDS EcSMS35_4953 NC_010498.1 5067678 5068364 D member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 5067678..5068364 Escherichia coli SMS-3-5 6144496 EcSMS35_0214 tRNA EcSMS35_0214 NC_010498.1 234517 234593 D tRNA-Ile 234517..234593 Escherichia coli SMS-3-5 6143731 EcSMS35_0215 tRNA EcSMS35_0215 NC_010498.1 234635 234712 D tRNA-Ala 234635..234712 Escherichia coli SMS-3-5 6143683 EcSMS35_0220 tRNA EcSMS35_0220 NC_010498.1 238053 238131 D tRNA-Asp 238053..238131 Escherichia coli SMS-3-5 6143719 EcSMS35_0230 tRNA EcSMS35_0230 NC_010498.1 246274 246352 D tRNA-Asp 246274..246352 Escherichia coli SMS-3-5 6143239 EcSMS35_0298 tRNA EcSMS35_0298 NC_010498.1 306640 306715 D tRNA-Thr 306640..306715 Escherichia coli SMS-3-5 6146796 EcSMS35_0358 tRNA EcSMS35_0358 NC_010498.1 370255 370335 D tRNA-OTHER 370255..370335 Escherichia coli SMS-3-5 6144555 EcSMS35_0582 tRNA EcSMS35_0582 NC_010498.1 588633 588711 D tRNA-Arg 588633..588711 Escherichia coli SMS-3-5 6143038 EcSMS35_0686 tRNA EcSMS35_0686 NC_010498.1 695948 696024 R tRNA-Gln complement(695948..696024) Escherichia coli SMS-3-5 6144415 EcSMS35_0687 tRNA EcSMS35_0687 NC_010498.1 696060 696136 R tRNA-Gln complement(696060..696136) Escherichia coli SMS-3-5 6143666 EcSMS35_0688 tRNA EcSMS35_0688 NC_010498.1 696183 696261 R tRNA-Met complement(696183..696261) Escherichia coli SMS-3-5 6143641 EcSMS35_0689 tRNA EcSMS35_0689 NC_010498.1 696275 696351 R tRNA-Gln complement(696275..696351) Escherichia coli SMS-3-5 6143638 EcSMS35_0690 tRNA EcSMS35_0690 NC_010498.1 696385 696459 R tRNA-Gln complement(696385..696459) Escherichia coli SMS-3-5 6143677 EcSMS35_0691 tRNA EcSMS35_0691 NC_010498.1 696482 696568 R tRNA-Leu complement(696482..696568) Escherichia coli SMS-3-5 6143695 EcSMS35_0692 tRNA EcSMS35_0692 NC_010498.1 696575 696653 R tRNA-Met complement(696575..696653) Escherichia coli SMS-3-5 6143648 EcSMS35_0766 tRNA EcSMS35_0766 NC_010498.1 773151 773228 D tRNA-Lys 773151..773228 Escherichia coli SMS-3-5 6146583 EcSMS35_0767 tRNA EcSMS35_0767 NC_010498.1 773263 773338 D tRNA-Val 773263..773338 Escherichia coli SMS-3-5 6143675 EcSMS35_0768 tRNA EcSMS35_0768 NC_010498.1 773341 773416 D tRNA-Lys 773341..773416 Escherichia coli SMS-3-5 6143646 EcSMS35_0769 tRNA EcSMS35_0769 NC_010498.1 773468 773543 D tRNA-Val 773468..773543 Escherichia coli SMS-3-5 6143625 EcSMS35_0770 tRNA EcSMS35_0770 NC_010498.1 773547 773622 D tRNA-Lys 773547..773622 Escherichia coli SMS-3-5 6143685 EcSMS35_0771 tRNA EcSMS35_0771 NC_010498.1 773670 773747 D tRNA-Lys 773670..773747 Escherichia coli SMS-3-5 6143693 EcSMS35_0772 tRNA EcSMS35_0772 NC_010498.1 773780 773855 D tRNA-Lys 773780..773855 Escherichia coli SMS-3-5 6143676 EcSMS35_1135 tRNA EcSMS35_1135 NC_010498.1 1154631 1154708 R tRNA-Asn complement(1154631..1154708) Escherichia coli SMS-3-5 6145550 EcSMS35_1138 tRNA EcSMS35_1138 NC_010498.1 1157040 1157117 R tRNA-Asn complement(1157040..1157117) Escherichia coli SMS-3-5 6146313 EcSMS35_1140 tRNA EcSMS35_1140 NC_010498.1 1158864 1158941 D tRNA-Asn 1158864..1158941 Escherichia coli SMS-3-5 6143554 EcSMS35_1147 tRNA EcSMS35_1147 NC_010498.1 1172341 1172418 R tRNA-Asn complement(1172341..1172418) Escherichia coli SMS-3-5 6144991 EcSMS35_1149 tRNA EcSMS35_1149 NC_010498.1 1173408 1173499 D tRNA-Ser 1173408..1173499 Escherichia coli SMS-3-5 6146117 EcSMS35_1177 tRNA EcSMS35_1177 NC_010498.1 1188836 1188911 D tRNA-Met 1188836..1188911 Escherichia coli SMS-3-5 6147365 EcSMS35_1178 tRNA EcSMS35_1178 NC_010498.1 1188912 1188990 D tRNA-Lys 1188912..1188990 Escherichia coli SMS-3-5 6143704 EcSMS35_1179 tRNA EcSMS35_1179 NC_010498.1 1188991 1189068 D tRNA-Thr 1188991..1189068 Escherichia coli SMS-3-5 6143701 EcSMS35_1180 tRNA EcSMS35_1180 NC_010498.1 1189071 1189145 D tRNA-Gly 1189071..1189145 Escherichia coli SMS-3-5 6143622 EcSMS35_1272 tRNA EcSMS35_1272 NC_010498.1 1267399 1267474 D tRNA-Gly 1267399..1267474 Escherichia coli SMS-3-5 6144596 EcSMS35_1273 tRNA EcSMS35_1273 NC_010498.1 1267529 1267602 D tRNA-Cys 1267529..1267602 Escherichia coli SMS-3-5 6143650 EcSMS35_1274 tRNA EcSMS35_1274 NC_010498.1 1267615 1267701 D tRNA-Leu 1267615..1267701 Escherichia coli SMS-3-5 6143665 EcSMS35_1531 tRNA EcSMS35_1531 NC_010498.1 1516266 1516344 R tRNA-Val complement(1516266..1516344) Escherichia coli SMS-3-5 6144204 EcSMS35_1532 tRNA EcSMS35_1532 NC_010498.1 1516347 1516425 R tRNA-Val complement(1516347..1516425) Escherichia coli SMS-3-5 6143694 EcSMS35_1910 tRNA EcSMS35_1910 NC_010498.1 1930658 1930744 D tRNA-Tyr 1930658..1930744 Escherichia coli SMS-3-5 6142878 EcSMS35_1911 tRNA EcSMS35_1911 NC_010498.1 1930777 1930863 D tRNA-Tyr 1930777..1930863 Escherichia coli SMS-3-5 6143681 EcSMS35_2101 tRNA EcSMS35_2101 NC_010498.1 2109643 2109732 D tRNA-Ser 2109643..2109732 Escherichia coli SMS-3-5 6146598 EcSMS35_2147 tRNA EcSMS35_2147 NC_010498.1 2155868 2155957 D tRNA-Ser 2155868..2155957 Escherichia coli SMS-3-5 6145617 EcSMS35_2238 tRNA EcSMS35_2238 NC_010498.1 2261373 2261462 D tRNA-Ser 2261373..2261462 Escherichia coli SMS-3-5 6145408 EcSMS35_2339 tRNA EcSMS35_2339 NC_010498.1 2371870 2371948 D tRNA-Pro 2371870..2371948 Escherichia coli SMS-3-5 6145776 EcSMS35_2508 tRNA EcSMS35_2508 NC_010498.1 2555193 2555269 D tRNA-Arg 2555193..2555269 Escherichia coli SMS-3-5 6146123 EcSMS35_2546 tRNA EcSMS35_2546 NC_010498.1 2607423 2607500 R tRNA-Ala complement(2607423..2607500) Escherichia coli SMS-3-5 6143304 EcSMS35_2547 tRNA EcSMS35_2547 NC_010498.1 2607539 2607614 R tRNA-Ala complement(2607539..2607614) Escherichia coli SMS-3-5 6143630 EcSMS35_2554 tRNA EcSMS35_2554 NC_010498.1 2612062 2612137 D tRNA-Val 2612062..2612137 Escherichia coli SMS-3-5 6143121 EcSMS35_2555 tRNA EcSMS35_2555 NC_010498.1 2612181 2612258 D tRNA-Val 2612181..2612258 Escherichia coli SMS-3-5 6143657 EcSMS35_2556 tRNA EcSMS35_2556 NC_010498.1 2612303 2612380 D tRNA-Val 2612303..2612380 Escherichia coli SMS-3-5 6143667 EcSMS35_2557 tRNA EcSMS35_2557 NC_010498.1 2612384 2612459 D tRNA-Lys 2612384..2612459 Escherichia coli SMS-3-5 6143705 EcSMS35_2744 tRNA EcSMS35_2744 NC_010498.1 2824422 2824499 R tRNA-Glu complement(2824422..2824499) Escherichia coli SMS-3-5 6143725 EcSMS35_2777 tRNA EcSMS35_2777 NC_010498.1 2859380 2859455 R tRNA-Met complement(2859380..2859455) Escherichia coli SMS-3-5 6145917 EcSMS35_2813 tRNA EcSMS35_2813 NC_010498.1 2893276 2893354 R tRNA-Arg complement(2893276..2893354) Escherichia coli SMS-3-5 6145042 EcSMS35_2814 tRNA EcSMS35_2814 NC_010498.1 2893416 2893494 R tRNA-Arg complement(2893416..2893494) Escherichia coli SMS-3-5 6143688 EcSMS35_2815 tRNA EcSMS35_2815 NC_010498.1 2893555 2893633 R tRNA-Arg complement(2893555..2893633) Escherichia coli SMS-3-5 6143621 EcSMS35_2816 tRNA EcSMS35_2816 NC_010498.1 2893696 2893774 R tRNA-Arg complement(2893696..2893774) Escherichia coli SMS-3-5 6143684 EcSMS35_2817 tRNA EcSMS35_2817 NC_010498.1 2893776 2893870 R tRNA-Ser complement(2893776..2893870) Escherichia coli SMS-3-5 6143671 EcSMS35_2955 tRNA EcSMS35_2955 NC_010498.1 3030525 3030601 D tRNA-Met 3030525..3030601 Escherichia coli SMS-3-5 6145311 EcSMS35_2956 tRNA EcSMS35_2956 NC_010498.1 3030635 3030711 D tRNA-Met 3030635..3030711 Escherichia coli SMS-3-5 6143673 EcSMS35_2957 tRNA EcSMS35_2957 NC_010498.1 3030746 3030822 D tRNA-Met 3030746..3030822 Escherichia coli SMS-3-5 6143672 EcSMS35_2997 tRNA EcSMS35_2997 NC_010498.1 3077965 3078040 R tRNA-Gly complement(3077965..3078040) Escherichia coli SMS-3-5 6146821 EcSMS35_3111 tRNA EcSMS35_3111 NC_010498.1 3197158 3197235 D tRNA-Phe 3197158..3197235 Escherichia coli SMS-3-5 6145289 EcSMS35_3363 tRNA EcSMS35_3363 NC_010498.1 3441715 3441792 D tRNA-Met 3441715..3441792 Escherichia coli SMS-3-5 6146472 EcSMS35_3467 tRNA EcSMS35_3467 NC_010498.1 3544969 3545045 R tRNA-Met complement(3544969..3545045) Escherichia coli SMS-3-5 6145000 EcSMS35_3470 tRNA EcSMS35_3470 NC_010498.1 3548827 3548915 R tRNA-Leu complement(3548827..3548915) Escherichia coli SMS-3-5 6144674 EcSMS35_3568 tRNA EcSMS35_3568 NC_010498.1 3650806 3650883 R tRNA-Thr complement(3650806..3650883) Escherichia coli SMS-3-5 6143710 EcSMS35_3572 tRNA EcSMS35_3572 NC_010498.1 3654193 3654270 R tRNA-Ala complement(3654193..3654270) Escherichia coli SMS-3-5 6143724 EcSMS35_3573 tRNA EcSMS35_3573 NC_010498.1 3654312 3654388 R tRNA-Ile complement(3654312..3654388) Escherichia coli SMS-3-5 6143709 EcSMS35_3866 tRNA EcSMS35_3866 NC_010498.1 3934763 3934841 R tRNA-Pro complement(3934763..3934841) Escherichia coli SMS-3-5 6147523 EcSMS35_4001 tRNA EcSMS35_4001 NC_010498.1 4081340 4081434 D tRNA-Sec 4081340..4081434 Escherichia coli SMS-3-5 6145405 EcSMS35_4125 tRNA EcSMS35_4125 NC_010498.1 4223228 4223305 D tRNA-Glu 4223228..4223305 Escherichia coli SMS-3-5 6143712 EcSMS35_4129 tRNA EcSMS35_4129 NC_010498.1 4226660 4226738 D tRNA-Asp 4226660..4226738 Escherichia coli SMS-3-5 6143717 EcSMS35_4130 tRNA EcSMS35_4130 NC_010498.1 4226745 4226822 D tRNA-Trp 4226745..4226822 Escherichia coli SMS-3-5 6143668 EcSMS35_4161 tRNA EcSMS35_4161 NC_010498.1 4262022 4262098 D tRNA-Arg 4262022..4262098 Escherichia coli SMS-3-5 6144681 EcSMS35_4162 tRNA EcSMS35_4162 NC_010498.1 4262156 4262233 D tRNA-His 4262156..4262233 Escherichia coli SMS-3-5 6143674 EcSMS35_4163 tRNA EcSMS35_4163 NC_010498.1 4262252 4262340 D tRNA-Leu 4262252..4262340 Escherichia coli SMS-3-5 6143664 EcSMS35_4164 tRNA EcSMS35_4164 NC_010498.1 4262381 4262459 D tRNA-Pro 4262381..4262459 Escherichia coli SMS-3-5 6143651 EcSMS35_4233 tRNA EcSMS35_4233 NC_010498.1 4332202 4332279 D tRNA-Glu 4332202..4332279 Escherichia coli SMS-3-5 6143723 EcSMS35_4416 tRNA EcSMS35_4416 NC_010498.1 4514108 4514185 D tRNA-Glu 4514108..4514185 Escherichia coli SMS-3-5 6143711 EcSMS35_4424 tRNA EcSMS35_4424 NC_010498.1 4520959 4521036 D tRNA-Thr 4520959..4521036 Escherichia coli SMS-3-5 6144382 EcSMS35_4425 tRNA EcSMS35_4425 NC_010498.1 4521044 4521128 D tRNA-Tyr 4521044..4521128 Escherichia coli SMS-3-5 6143654 EcSMS35_4426 tRNA EcSMS35_4426 NC_010498.1 4521245 4521319 D tRNA-Gly 4521245..4521319 Escherichia coli SMS-3-5 6143680 EcSMS35_4427 tRNA EcSMS35_4427 NC_010498.1 4521325 4521402 D tRNA-Thr 4521325..4521402 Escherichia coli SMS-3-5 6143642 EcSMS35_4458 tRNA EcSMS35_4458 NC_010498.1 4554279 4554356 D tRNA-Glu 4554279..4554356 Escherichia coli SMS-3-5 6143726 EcSMS35_4603 tRNA EcSMS35_4603 NC_010498.1 4707517 4707594 R tRNA-Phe complement(4707517..4707594) Escherichia coli SMS-3-5 6145185 EcSMS35_4634 tRNA EcSMS35_4634 NC_010498.1 4737021 4737096 D tRNA-Gly 4737021..4737096 Escherichia coli SMS-3-5 6146151 EcSMS35_4635 tRNA EcSMS35_4635 NC_010498.1 4737253 4737330 D tRNA-Gly 4737253..4737330 Escherichia coli SMS-3-5 6143670 EcSMS35_4636 tRNA EcSMS35_4636 NC_010498.1 4737364 4737441 D tRNA-Gly 4737364..4737441 Escherichia coli SMS-3-5 6143696 EcSMS35_4752 tRNA EcSMS35_4752 NC_010498.1 4851314 4851400 D tRNA-Leu 4851314..4851400 Escherichia coli SMS-3-5 6142613 EcSMS35_4915 tRNA EcSMS35_4915 NC_010498.1 5034411 5034499 R tRNA-Leu complement(5034411..5034499) Escherichia coli SMS-3-5 6145249 EcSMS35_4916 tRNA EcSMS35_4916 NC_010498.1 5034533 5034619 R tRNA-Leu complement(5034533..5034619) Escherichia coli SMS-3-5 6143634 EcSMS35_4917 tRNA EcSMS35_4917 NC_010498.1 5034647 5034735 R tRNA-Leu complement(5034647..5034735) Escherichia coli SMS-3-5 6143682 EcSMS35_0213 rRNA rrs NC_010498.1 232907 234448 D 16S ribosomal RNA 232907..234448 Escherichia coli SMS-3-5 6144374 EcSMS35_0218 rRNA rrl NC_010498.1 234886 237789 D 23S ribosomal RNA 234886..237789 Escherichia coli SMS-3-5 6143640 EcSMS35_0219 rRNA rrf NC_010498.1 237884 237999 D 5S ribosomal RNA 237884..237999 Escherichia coli SMS-3-5 6143728 EcSMS35_2741 rRNA rrf NC_010498.1 2821115 2821230 R 5S ribosomal RNA complement(2821115..2821230) Escherichia coli SMS-3-5 6146565 EcSMS35_2742 rRNA rrl NC_010498.1 2821325 2824229 R 23S ribosomal RNA complement(2821325..2824229) Escherichia coli SMS-3-5 6143720 EcSMS35_2745 rRNA rrs NC_010498.1 2824584 2826125 R 16S ribosomal RNA complement(2824584..2826125) Escherichia coli SMS-3-5 6143628 EcSMS35_3567 rRNA rrf NC_010498.1 3650652 3650767 R 5S ribosomal RNA complement(3650652..3650767) Escherichia coli SMS-3-5 6144593 EcSMS35_3569 rRNA rrf NC_010498.1 3650897 3651012 R 5S ribosomal RNA complement(3650897..3651012) Escherichia coli SMS-3-5 6143636 EcSMS35_3570 rRNA rrl NC_010498.1 3651109 3654010 R 23S ribosomal RNA complement(3651109..3654010) Escherichia coli SMS-3-5 6143714 EcSMS35_3574 rRNA rrs NC_010498.1 3654457 3655998 R 16S ribosomal RNA complement(3654457..3655998) Escherichia coli SMS-3-5 6143623 EcSMS35_4124 rRNA rrs NC_010498.1 4221605 4223143 D 16S ribosomal RNA 4221605..4223143 Escherichia coli SMS-3-5 6146183 EcSMS35_4127 rRNA rrl NC_010498.1 4223489 4226394 D 23S ribosomal RNA 4223489..4226394 Escherichia coli SMS-3-5 6143692 EcSMS35_4128 rRNA rrf NC_010498.1 4226491 4226606 D 5S ribosomal RNA 4226491..4226606 Escherichia coli SMS-3-5 6143729 EcSMS35_4232 rRNA rrs NC_010498.1 4330576 4332117 D 16S ribosomal RNA 4330576..4332117 Escherichia coli SMS-3-5 6145677 EcSMS35_4235 rRNA rrl NC_010498.1 4332472 4335376 D 23S ribosomal RNA 4332472..4335376 Escherichia coli SMS-3-5 6143663 EcSMS35_4236 rRNA rrf NC_010498.1 4335471 4335586 D 5S ribosomal RNA 4335471..4335586 Escherichia coli SMS-3-5 6143718 EcSMS35_4415 rRNA rrs NC_010498.1 4512482 4514023 D 16S ribosomal RNA 4512482..4514023 Escherichia coli SMS-3-5 6144421 EcSMS35_4418 rRNA rrl NC_010498.1 4514378 4517282 D 23S ribosomal RNA 4514378..4517282 Escherichia coli SMS-3-5 6143629 EcSMS35_4419 rRNA rrf NC_010498.1 4517377 4517492 D 5S ribosomal RNA 4517377..4517492 Escherichia coli SMS-3-5 6143722 EcSMS35_4457 rRNA rrs NC_010498.1 4552653 4554194 D 16S ribosomal RNA 4552653..4554194 Escherichia coli SMS-3-5 6145857 EcSMS35_4461 rRNA rrl NC_010498.1 4554549 4557452 D 23S ribosomal RNA 4554549..4557452 Escherichia coli SMS-3-5 6143649 EcSMS35_4462 rRNA rrf NC_010498.1 4557547 4557662 D 5S ribosomal RNA 4557547..4557662 Escherichia coli SMS-3-5 6143721