-- dump date 20120504_144414 -- class Genbank::misc_feature -- table misc_feature_note -- id note 360911000001 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 360911000002 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 360911000003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911000004 ATP binding site [chemical binding]; other site 360911000005 putative Mg++ binding site [ion binding]; other site 360911000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000007 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 360911000008 nucleotide binding site [chemical binding]; other site 360911000009 Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241 360911000010 HNH endonuclease; Region: HNH_3; pfam13392 360911000011 NUMOD1 domain; Region: NUMOD1; cl11508 360911000012 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 360911000013 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 360911000014 active site 360911000015 catalytic site [active] 360911000016 substrate binding site [chemical binding]; other site 360911000017 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 360911000018 active site 360911000019 DNA binding site [nucleotide binding] 360911000020 catalytic site [active] 360911000021 3D domain; Region: 3D; cl01439 360911000022 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 360911000023 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 360911000024 Terminase-like family; Region: Terminase_6; pfam03237 360911000025 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 360911000026 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 360911000027 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 360911000028 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 360911000029 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 360911000030 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 360911000031 Phage XkdN-like protein; Region: XkdN; pfam08890 360911000032 Phage-related minor tail protein [Function unknown]; Region: COG5280 360911000033 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 360911000034 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 360911000035 3D domain; Region: 3D; cl01439 360911000036 NlpC/P60 family; Region: NLPC_P60; cl11438 360911000037 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 360911000038 Baseplate J-like protein; Region: Baseplate_J; cl01294 360911000039 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 360911000040 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 360911000041 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 360911000042 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911000043 putative peptidoglycan binding site; other site 360911000044 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911000045 putative peptidoglycan binding site; other site 360911000046 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 360911000047 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 360911000048 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 360911000049 cell division protein GpsB; Provisional; Region: PRK14127 360911000050 DivIVA domain; Region: DivI1A_domain; TIGR03544 360911000051 Restriction endonuclease; Region: Mrr_cat; cl00516 360911000052 FAD binding domain; Region: FAD_binding_3; pfam01494 360911000053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000054 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 360911000055 putative active site [active] 360911000056 putative CoA binding site [chemical binding]; other site 360911000057 nudix motif; other site 360911000058 metal binding site [ion binding]; metal-binding site 360911000059 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 360911000060 GDYXXLXY protein; Region: GDYXXLXY; cl02066 360911000061 3D domain; Region: 3D; cl01439 360911000062 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 360911000063 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 360911000064 Walker A/P-loop; other site 360911000065 ATP binding site [chemical binding]; other site 360911000066 Q-loop/lid; other site 360911000067 ABC transporter signature motif; other site 360911000068 Walker B; other site 360911000069 D-loop; other site 360911000070 H-loop/switch region; other site 360911000071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911000072 dimer interface [polypeptide binding]; other site 360911000073 conserved gate region; other site 360911000074 ABC-ATPase subunit interface; other site 360911000075 NMT1-like family; Region: NMT1_2; cl15260 360911000076 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 360911000077 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 360911000078 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 360911000079 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 360911000080 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 360911000081 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 360911000082 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 360911000083 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 360911000084 active site 360911000085 Zn binding site [ion binding]; other site 360911000086 histidinol-phosphatase; Reviewed; Region: PRK08123 360911000087 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 360911000088 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 360911000089 motif 1; other site 360911000090 dimer interface [polypeptide binding]; other site 360911000091 active site 360911000092 motif 2; other site 360911000093 motif 3; other site 360911000094 ATP phosphoribosyltransferase; Region: HisG; cl15266 360911000095 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 360911000096 histidinol dehydrogenase; Region: hisD; TIGR00069 360911000097 NAD binding site [chemical binding]; other site 360911000098 dimerization interface [polypeptide binding]; other site 360911000099 product binding site; other site 360911000100 substrate binding site [chemical binding]; other site 360911000101 zinc binding site [ion binding]; other site 360911000102 catalytic residues [active] 360911000103 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 360911000104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000106 homodimer interface [polypeptide binding]; other site 360911000107 catalytic residue [active] 360911000108 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 360911000109 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 360911000110 putative active site pocket [active] 360911000111 4-fold oligomerization interface [polypeptide binding]; other site 360911000112 metal binding residues [ion binding]; metal-binding site 360911000113 3-fold/trimer interface [polypeptide binding]; other site 360911000114 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 360911000115 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 360911000116 putative active site [active] 360911000117 oxyanion strand; other site 360911000118 catalytic triad [active] 360911000119 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 360911000120 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 360911000121 catalytic residues [active] 360911000122 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 360911000123 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 360911000124 substrate binding site [chemical binding]; other site 360911000125 glutamase interaction surface [polypeptide binding]; other site 360911000126 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 360911000127 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 360911000128 maltose O-acetyltransferase; Provisional; Region: PRK10092 360911000129 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 360911000130 active site 360911000131 substrate binding site [chemical binding]; other site 360911000132 trimer interface [polypeptide binding]; other site 360911000133 CoA binding site [chemical binding]; other site 360911000134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000135 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 360911000136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000137 homodimer interface [polypeptide binding]; other site 360911000138 catalytic residue [active] 360911000139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911000140 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911000141 substrate binding pocket [chemical binding]; other site 360911000142 membrane-bound complex binding site; other site 360911000143 hinge residues; other site 360911000144 AAA domain; Region: AAA_33; pfam13671 360911000145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000147 Coenzyme A binding pocket [chemical binding]; other site 360911000148 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911000149 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911000150 active site 360911000151 metal binding site [ion binding]; metal-binding site 360911000152 topology modulation protein; Reviewed; Region: PRK08118 360911000153 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000154 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 360911000155 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911000156 Protein of unknown function (DUF964); Region: DUF964; cl01483 360911000157 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 360911000158 MutS domain I; Region: MutS_I; pfam01624 360911000159 MutS domain II; Region: MutS_II; pfam05188 360911000160 MutS family domain IV; Region: MutS_IV; pfam05190 360911000161 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 360911000162 Walker A/P-loop; other site 360911000163 ATP binding site [chemical binding]; other site 360911000164 Q-loop/lid; other site 360911000165 ABC transporter signature motif; other site 360911000166 Walker B; other site 360911000167 D-loop; other site 360911000168 H-loop/switch region; other site 360911000169 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 360911000170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911000171 ATP binding site [chemical binding]; other site 360911000172 Mg2+ binding site [ion binding]; other site 360911000173 G-X-G motif; other site 360911000174 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 360911000175 ATP binding site [chemical binding]; other site 360911000176 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 360911000177 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 360911000178 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 360911000179 5S rRNA interface [nucleotide binding]; other site 360911000180 CTC domain interface [polypeptide binding]; other site 360911000181 L16 interface [polypeptide binding]; other site 360911000182 Cupin domain; Region: Cupin_2; cl09118 360911000183 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 360911000184 RNAase interaction site [polypeptide binding]; other site 360911000185 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 360911000186 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 360911000187 Class III ribonucleotide reductase; Region: RNR_III; cd01675 360911000188 effector binding site; other site 360911000189 active site 360911000190 Zn binding site [ion binding]; other site 360911000191 glycine loop; other site 360911000192 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 360911000193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911000194 FeS/SAM binding site; other site 360911000195 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 360911000196 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 360911000197 serine endoprotease; Provisional; Region: PRK10898 360911000198 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 360911000199 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911000200 protein binding site [polypeptide binding]; other site 360911000201 Predicted membrane protein [Function unknown]; Region: COG4270 360911000202 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 360911000203 amidohydrolase; Region: amidohydrolases; TIGR01891 360911000204 metal binding site [ion binding]; metal-binding site 360911000205 putative dimer interface [polypeptide binding]; other site 360911000206 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 360911000207 Predicted transcriptional regulator [Transcription]; Region: COG3355 360911000208 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 360911000209 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 360911000210 active site 360911000211 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 360911000212 active site 360911000213 catalytic triad [active] 360911000214 oxyanion hole [active] 360911000215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911000216 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 360911000217 Walker A/P-loop; other site 360911000218 ATP binding site [chemical binding]; other site 360911000219 Q-loop/lid; other site 360911000220 ABC transporter signature motif; other site 360911000221 Walker B; other site 360911000222 D-loop; other site 360911000223 H-loop/switch region; other site 360911000224 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911000225 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 360911000226 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 360911000227 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 360911000228 active site 360911000229 Zn binding site [ion binding]; other site 360911000230 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 360911000231 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 360911000232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000233 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 360911000234 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 360911000235 Sm1 motif; other site 360911000236 intra - hexamer interaction site; other site 360911000237 inter - hexamer interaction site [polypeptide binding]; other site 360911000238 nucleotide binding pocket [chemical binding]; other site 360911000239 Sm2 motif; other site 360911000240 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 360911000241 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 360911000242 generic binding surface I; other site 360911000243 generic binding surface II; other site 360911000244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911000245 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 360911000246 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000247 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 360911000248 5'-3' exonuclease; Region: 53EXOc; smart00475 360911000249 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360911000250 active site 360911000251 metal binding site 1 [ion binding]; metal-binding site 360911000252 putative 5' ssDNA interaction site; other site 360911000253 metal binding site 3; metal-binding site 360911000254 metal binding site 2 [ion binding]; metal-binding site 360911000255 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360911000256 putative DNA binding site [nucleotide binding]; other site 360911000257 putative metal binding site [ion binding]; other site 360911000258 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 360911000259 RNA/DNA hybrid binding site [nucleotide binding]; other site 360911000260 active site 360911000261 fumarate hydratase; Reviewed; Region: fumC; PRK00485 360911000262 Class II fumarases; Region: Fumarase_classII; cd01362 360911000263 active site 360911000264 tetramer interface [polypeptide binding]; other site 360911000265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911000266 metal binding site [ion binding]; metal-binding site 360911000267 active site 360911000268 I-site; other site 360911000269 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 360911000270 folate binding site [chemical binding]; other site 360911000271 NADP+ binding site [chemical binding]; other site 360911000272 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 360911000273 dimerization interface [polypeptide binding]; other site 360911000274 active site 360911000275 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 360911000276 intracellular protease, PfpI family; Region: PfpI; TIGR01382 360911000277 proposed catalytic triad [active] 360911000278 conserved cys residue [active] 360911000279 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 360911000280 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 360911000281 Helix-turn-helix domains; Region: HTH; cl00088 360911000282 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911000283 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 360911000284 Walker A/P-loop; other site 360911000285 ATP binding site [chemical binding]; other site 360911000286 Q-loop/lid; other site 360911000287 ABC transporter signature motif; other site 360911000288 Walker B; other site 360911000289 D-loop; other site 360911000290 H-loop/switch region; other site 360911000291 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911000292 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911000293 active site 360911000294 catalytic tetrad [active] 360911000295 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 360911000296 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 360911000297 active site 360911000298 dimer interface [polypeptide binding]; other site 360911000299 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 360911000300 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 360911000301 active site 360911000302 FMN binding site [chemical binding]; other site 360911000303 substrate binding site [chemical binding]; other site 360911000304 3Fe-4S cluster binding site [ion binding]; other site 360911000305 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 360911000306 domain interface; other site 360911000307 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 360911000308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000309 Predicted permease [General function prediction only]; Region: COG2056 360911000310 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 360911000311 Transcriptional regulator; Region: Transcrip_reg; cl00361 360911000312 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911000313 Helix-turn-helix domains; Region: HTH; cl00088 360911000314 Helix-turn-helix domains; Region: HTH; cl00088 360911000315 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 360911000316 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 360911000317 putative catalytic cysteine [active] 360911000318 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 360911000319 putative active site [active] 360911000320 metal binding site [ion binding]; metal-binding site 360911000321 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 360911000322 metal binding site [ion binding]; metal-binding site 360911000323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000325 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 360911000326 Helix-turn-helix domains; Region: HTH; cl00088 360911000327 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 360911000328 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 360911000329 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 360911000330 putative substrate binding site [chemical binding]; other site 360911000331 putative ATP binding site [chemical binding]; other site 360911000332 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 360911000333 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360911000334 active site 360911000335 phosphorylation site [posttranslational modification] 360911000336 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 360911000337 active site 360911000338 P-loop; other site 360911000339 phosphorylation site [posttranslational modification] 360911000340 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911000341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911000342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000343 Coenzyme A binding pocket [chemical binding]; other site 360911000344 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911000345 active site 360911000346 metal binding site [ion binding]; metal-binding site 360911000347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911000348 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 360911000349 putative nucleotide binding site [chemical binding]; other site 360911000350 uridine monophosphate binding site [chemical binding]; other site 360911000351 homohexameric interface [polypeptide binding]; other site 360911000352 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 360911000353 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 360911000354 putative catalytic residues [active] 360911000355 Cache domain; Region: Cache_1; pfam02743 360911000356 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 360911000357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911000358 dimerization interface [polypeptide binding]; other site 360911000359 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911000360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911000361 dimer interface [polypeptide binding]; other site 360911000362 putative CheW interface [polypeptide binding]; other site 360911000363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911000364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 360911000365 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 360911000366 Probable transposase; Region: OrfB_IS605; pfam01385 360911000367 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 360911000368 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 360911000369 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911000370 putative active site [active] 360911000371 catalytic site [active] 360911000372 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911000373 putative active site [active] 360911000374 catalytic site [active] 360911000375 OsmC-like protein; Region: OsmC; cl00767 360911000376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000377 Coenzyme A binding pocket [chemical binding]; other site 360911000378 putative oxidoreductase; Provisional; Region: PRK11579 360911000379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000380 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 360911000381 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911000382 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 360911000383 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 360911000384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911000385 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 360911000386 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911000387 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 360911000388 adhesin; Provisional; Region: PRK09752 360911000389 PilZ domain; Region: PilZ; cl01260 360911000390 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 360911000391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 360911000392 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 360911000393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000394 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 360911000395 Cation efflux family; Region: Cation_efflux; cl00316 360911000396 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911000397 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911000398 DNA binding site [nucleotide binding] 360911000399 domain linker motif; other site 360911000400 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 360911000401 dimerization interface [polypeptide binding]; other site 360911000402 ligand binding site [chemical binding]; other site 360911000403 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360911000404 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 360911000405 putative substrate binding site [chemical binding]; other site 360911000406 putative ATP binding site [chemical binding]; other site 360911000407 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 360911000408 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911000409 active site turn [active] 360911000410 phosphorylation site [posttranslational modification] 360911000411 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911000412 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 360911000413 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 360911000414 substrate binding [chemical binding]; other site 360911000415 active site 360911000416 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 360911000417 haloalkane dehalogenase; Provisional; Region: PRK03592 360911000418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000419 WYL domain; Region: WYL; cl14852 360911000420 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 360911000421 Protein of unknown function (DUF817); Region: DUF817; cl01520 360911000422 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 360911000423 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 360911000424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911000425 dimer interface [polypeptide binding]; other site 360911000426 conserved gate region; other site 360911000427 putative PBP binding loops; other site 360911000428 ABC-ATPase subunit interface; other site 360911000429 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911000430 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 360911000431 putative NAD(P) binding site [chemical binding]; other site 360911000432 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 360911000433 catalytic triad [active] 360911000434 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 360911000435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911000436 active site 360911000437 metal binding site [ion binding]; metal-binding site 360911000438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911000439 metal binding site [ion binding]; metal-binding site 360911000440 active site 360911000441 I-site; other site 360911000442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911000444 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 360911000445 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911000446 DNA binding residues [nucleotide binding] 360911000447 dimer interface [polypeptide binding]; other site 360911000448 CAAX protease self-immunity; Region: Abi; cl00558 360911000449 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 360911000450 nudix motif; other site 360911000451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000453 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911000454 putative substrate translocation pore; other site 360911000455 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 360911000456 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 360911000457 active site 360911000458 Zn binding site [ion binding]; other site 360911000459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911000460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000461 putative substrate translocation pore; other site 360911000462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911000463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360911000464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911000465 TIR domain; Region: TIR_2; cl15770 360911000466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911000467 non-specific DNA binding site [nucleotide binding]; other site 360911000468 salt bridge; other site 360911000469 sequence-specific DNA binding site [nucleotide binding]; other site 360911000470 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 360911000471 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 360911000472 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911000473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000474 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 360911000475 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 360911000476 Helix-turn-helix domains; Region: HTH; cl00088 360911000477 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 360911000478 putative dimerization interface [polypeptide binding]; other site 360911000479 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 360911000480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000481 NAD(P) binding site [chemical binding]; other site 360911000482 active site 360911000483 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 360911000484 Dynamin family; Region: Dynamin_N; pfam00350 360911000485 G1 box; other site 360911000486 GTP/Mg2+ binding site [chemical binding]; other site 360911000487 G2 box; other site 360911000488 Switch I region; other site 360911000489 G3 box; other site 360911000490 Switch II region; other site 360911000491 G4 box; other site 360911000492 G5 box; other site 360911000493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000494 Dynamin family; Region: Dynamin_N; pfam00350 360911000495 G1 box; other site 360911000496 GTP/Mg2+ binding site [chemical binding]; other site 360911000497 G2 box; other site 360911000498 Switch I region; other site 360911000499 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 360911000500 G3 box; other site 360911000501 Switch II region; other site 360911000502 GTP/Mg2+ binding site [chemical binding]; other site 360911000503 G4 box; other site 360911000504 G5 box; other site 360911000505 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 360911000506 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911000507 NAD binding site [chemical binding]; other site 360911000508 substrate binding site [chemical binding]; other site 360911000509 putative active site [active] 360911000510 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 360911000511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911000512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000513 Walker A/P-loop; other site 360911000514 ATP binding site [chemical binding]; other site 360911000515 Q-loop/lid; other site 360911000516 ABC transporter signature motif; other site 360911000517 Walker B; other site 360911000518 D-loop; other site 360911000519 H-loop/switch region; other site 360911000520 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 360911000521 Bacterial PH domain; Region: DUF304; cl01348 360911000522 Predicted membrane protein [Function unknown]; Region: COG3428 360911000523 Bacterial PH domain; Region: DUF304; cl01348 360911000524 Bacterial PH domain; Region: DUF304; cl01348 360911000525 Bacterial PH domain; Region: DUF304; cl01348 360911000526 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360911000527 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 360911000528 DinB superfamily; Region: DinB_2; pfam12867 360911000529 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 360911000530 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911000531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000532 Walker A motif; other site 360911000533 ATP binding site [chemical binding]; other site 360911000534 Walker B motif; other site 360911000535 arginine finger; other site 360911000536 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911000537 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 360911000538 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 360911000539 nudix motif; other site 360911000540 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911000541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911000542 DNA-binding site [nucleotide binding]; DNA binding site 360911000543 UTRA domain; Region: UTRA; cl01230 360911000544 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911000545 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911000546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911000547 dimerization interface [polypeptide binding]; other site 360911000548 putative DNA binding site [nucleotide binding]; other site 360911000549 putative Zn2+ binding site [ion binding]; other site 360911000550 short chain dehydrogenase; Provisional; Region: PRK06179 360911000551 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 360911000552 NADP binding site [chemical binding]; other site 360911000553 active site 360911000554 steroid binding site; other site 360911000555 Excalibur calcium-binding domain; Region: Excalibur; cl05460 360911000556 Helix-turn-helix domains; Region: HTH; cl00088 360911000557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000559 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000560 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000561 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000562 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 360911000563 classical (c) SDRs; Region: SDR_c; cd05233 360911000564 NAD(P) binding site [chemical binding]; other site 360911000565 active site 360911000566 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360911000567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911000568 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 360911000569 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911000570 putative peptidoglycan binding site; other site 360911000571 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911000572 putative peptidoglycan binding site; other site 360911000573 3D domain; Region: 3D; cl01439 360911000574 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 360911000575 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 360911000576 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 360911000577 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911000578 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911000579 putative active site [active] 360911000580 catalytic site [active] 360911000581 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911000582 putative active site [active] 360911000583 catalytic site [active] 360911000584 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911000585 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 360911000586 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911000587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000588 Walker A motif; other site 360911000589 ATP binding site [chemical binding]; other site 360911000590 Walker B motif; other site 360911000591 arginine finger; other site 360911000592 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360911000593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911000594 dimer interface [polypeptide binding]; other site 360911000595 conserved gate region; other site 360911000596 putative PBP binding loops; other site 360911000597 ABC-ATPase subunit interface; other site 360911000598 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911000599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911000600 substrate binding pocket [chemical binding]; other site 360911000601 membrane-bound complex binding site; other site 360911000602 hinge residues; other site 360911000603 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911000604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000605 Coenzyme A binding pocket [chemical binding]; other site 360911000606 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911000607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911000608 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 360911000609 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 360911000610 nudix motif; other site 360911000611 DinB superfamily; Region: DinB_2; pfam12867 360911000612 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 360911000613 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 360911000614 CAP-like domain; other site 360911000615 active site 360911000616 primary dimer interface [polypeptide binding]; other site 360911000617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911000618 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911000619 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911000620 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 360911000621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911000622 ATP binding site [chemical binding]; other site 360911000623 Mg2+ binding site [ion binding]; other site 360911000624 G-X-G motif; other site 360911000625 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 360911000626 anchoring element; other site 360911000627 dimer interface [polypeptide binding]; other site 360911000628 ATP binding site [chemical binding]; other site 360911000629 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 360911000630 active site 360911000631 putative metal-binding site [ion binding]; other site 360911000632 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 360911000633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911000635 metal binding site [ion binding]; metal-binding site 360911000636 active site 360911000637 I-site; other site 360911000638 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 360911000639 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911000640 active site 360911000641 DNA binding site [nucleotide binding] 360911000642 Int/Topo IB signature motif; other site 360911000643 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 360911000644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000646 homodimer interface [polypeptide binding]; other site 360911000647 catalytic residue [active] 360911000648 Protein of unknown function DUF45; Region: DUF45; cl00636 360911000649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911000650 PAS domain; Region: PAS_9; pfam13426 360911000651 putative active site [active] 360911000652 heme pocket [chemical binding]; other site 360911000653 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911000654 dimer interface [polypeptide binding]; other site 360911000655 putative CheW interface [polypeptide binding]; other site 360911000656 Domain of unknown function DUF302; Region: DUF302; cl01364 360911000657 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 360911000658 ArsC family; Region: ArsC; pfam03960 360911000659 putative catalytic residues [active] 360911000660 thiol/disulfide switch; other site 360911000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 360911000662 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 360911000663 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 360911000664 Walker A/P-loop; other site 360911000665 ATP binding site [chemical binding]; other site 360911000666 Q-loop/lid; other site 360911000667 ABC transporter signature motif; other site 360911000668 Walker B; other site 360911000669 D-loop; other site 360911000670 H-loop/switch region; other site 360911000671 NIL domain; Region: NIL; cl09633 360911000672 NMT1-like family; Region: NMT1_2; cl15260 360911000673 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 360911000674 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 360911000675 putative active site [active] 360911000676 metal binding site [ion binding]; metal-binding site 360911000677 transaminase; Reviewed; Region: PRK08068 360911000678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000680 homodimer interface [polypeptide binding]; other site 360911000681 catalytic residue [active] 360911000682 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360911000683 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 360911000684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911000686 putative substrate translocation pore; other site 360911000687 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 360911000688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000689 putative substrate translocation pore; other site 360911000690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 360911000691 glutamine synthetase, type I; Region: GlnA; TIGR00653 360911000692 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 360911000693 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 360911000694 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 360911000695 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 360911000696 putative NAD(P) binding site [chemical binding]; other site 360911000697 active site 360911000698 putative substrate binding site [chemical binding]; other site 360911000699 Heat induced stress protein YflT; Region: YflT; pfam11181 360911000700 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911000701 synthetase active site [active] 360911000702 NTP binding site [chemical binding]; other site 360911000703 metal binding site [ion binding]; metal-binding site 360911000704 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911000705 Helix-turn-helix domains; Region: HTH; cl00088 360911000706 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 360911000707 active site 360911000708 putative catalytic site [active] 360911000709 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 360911000710 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 360911000711 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 360911000712 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 360911000713 active site 360911000714 catalytic site [active] 360911000715 metal binding site [ion binding]; metal-binding site 360911000716 dimer interface [polypeptide binding]; other site 360911000717 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 360911000718 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 360911000719 active site 360911000720 Zn binding site [ion binding]; other site 360911000721 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 360911000722 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 360911000723 [2Fe-2S] cluster binding site [ion binding]; other site 360911000724 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 360911000725 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911000726 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360911000727 Sodium:solute symporter family; Region: SSF; cl00456 360911000728 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 360911000729 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911000730 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911000731 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911000732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000733 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 360911000734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911000735 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 360911000736 active site 360911000737 catalytic residues [active] 360911000738 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911000739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911000740 active site 360911000741 phosphorylation site [posttranslational modification] 360911000742 intermolecular recognition site; other site 360911000743 dimerization interface [polypeptide binding]; other site 360911000744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911000745 DNA binding site [nucleotide binding] 360911000746 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911000747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911000748 dimerization interface [polypeptide binding]; other site 360911000749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911000750 dimer interface [polypeptide binding]; other site 360911000751 phosphorylation site [posttranslational modification] 360911000752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911000753 ATP binding site [chemical binding]; other site 360911000754 Mg2+ binding site [ion binding]; other site 360911000755 G-X-G motif; other site 360911000756 FtsX-like permease family; Region: FtsX; cl15850 360911000757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911000758 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 360911000759 Walker A/P-loop; other site 360911000760 ATP binding site [chemical binding]; other site 360911000761 Q-loop/lid; other site 360911000762 ABC transporter signature motif; other site 360911000763 Walker B; other site 360911000764 D-loop; other site 360911000765 H-loop/switch region; other site 360911000766 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000767 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000768 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000769 CAAX protease self-immunity; Region: Abi; cl00558 360911000770 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 360911000771 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360911000772 catalytic residue [active] 360911000773 Cobalt transport protein; Region: CbiQ; cl00463 360911000774 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911000775 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 360911000776 Walker A/P-loop; other site 360911000777 ATP binding site [chemical binding]; other site 360911000778 Q-loop/lid; other site 360911000779 ABC transporter signature motif; other site 360911000780 Walker B; other site 360911000781 D-loop; other site 360911000782 H-loop/switch region; other site 360911000783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000784 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 360911000785 Walker A/P-loop; other site 360911000786 ATP binding site [chemical binding]; other site 360911000787 Q-loop/lid; other site 360911000788 ABC transporter signature motif; other site 360911000789 Walker B; other site 360911000790 D-loop; other site 360911000791 H-loop/switch region; other site 360911000792 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 360911000793 YKOF-related Family; Region: Ykof; pfam07615 360911000794 YKOF-related Family; Region: Ykof; pfam07615 360911000795 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 360911000796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000797 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 360911000798 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 360911000799 Strictosidine synthase; Region: Str_synth; pfam03088 360911000800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000801 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 360911000802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911000803 FeS/SAM binding site; other site 360911000804 amidase; Provisional; Region: PRK06828 360911000805 Amidase; Region: Amidase; cl11426 360911000806 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 360911000807 Electron transfer DM13; Region: DM13; cl02735 360911000808 acyl-CoA synthetase; Validated; Region: PRK07788 360911000809 AMP-binding enzyme; Region: AMP-binding; cl15778 360911000810 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911000811 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 360911000812 classical (c) SDRs; Region: SDR_c; cd05233 360911000813 NAD(P) binding site [chemical binding]; other site 360911000814 active site 360911000815 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 360911000816 putative hydrophobic ligand binding site [chemical binding]; other site 360911000817 EamA-like transporter family; Region: EamA; cl01037 360911000818 Sugar transport protein; Region: Sugar_transport; pfam06800 360911000819 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 360911000820 dimerization interface [polypeptide binding]; other site 360911000821 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 360911000822 active site 360911000823 catalytic site [active] 360911000824 substrate binding site [chemical binding]; other site 360911000825 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911000826 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 360911000827 Ligand binding site; other site 360911000828 Putative Catalytic site; other site 360911000829 DXD motif; other site 360911000830 GtrA-like protein; Region: GtrA; cl00971 360911000831 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 360911000832 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 360911000833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911000834 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 360911000835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000836 NAD(P) binding site [chemical binding]; other site 360911000837 active site 360911000838 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 360911000839 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911000840 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 360911000841 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 360911000842 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911000843 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911000844 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 360911000845 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360911000846 Sodium:solute symporter family; Region: SSF; cl00456 360911000847 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 360911000848 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 360911000849 putative active site [active] 360911000850 putative metal binding site [ion binding]; other site 360911000851 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 360911000852 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 360911000853 ANP binding site [chemical binding]; other site 360911000854 Substrate Binding Site II [chemical binding]; other site 360911000855 Substrate Binding Site I [chemical binding]; other site 360911000856 argininosuccinate lyase; Provisional; Region: PRK00855 360911000857 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 360911000858 active sites [active] 360911000859 tetramer interface [polypeptide binding]; other site 360911000860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911000861 Helix-turn-helix domains; Region: HTH; cl00088 360911000862 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 360911000863 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 360911000864 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000865 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 360911000866 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911000867 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 360911000868 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 360911000869 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 360911000870 Walker A/P-loop; other site 360911000871 ATP binding site [chemical binding]; other site 360911000872 Q-loop/lid; other site 360911000873 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 360911000874 ABC transporter signature motif; other site 360911000875 Walker B; other site 360911000876 D-loop; other site 360911000877 H-loop/switch region; other site 360911000878 exonuclease subunit SbcD; Provisional; Region: PRK10966 360911000879 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 360911000880 active site 360911000881 metal binding site [ion binding]; metal-binding site 360911000882 DNA binding site [nucleotide binding] 360911000883 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 360911000884 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 360911000885 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911000886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000887 Walker A/P-loop; other site 360911000888 ATP binding site [chemical binding]; other site 360911000889 Q-loop/lid; other site 360911000890 ABC transporter signature motif; other site 360911000891 Walker B; other site 360911000892 D-loop; other site 360911000893 H-loop/switch region; other site 360911000894 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 360911000895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 360911000897 Protein of unknown function (DUF975); Region: DUF975; cl10504 360911000898 CutC family; Region: CutC; cl01218 360911000899 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360911000900 Helix-turn-helix domains; Region: HTH; cl00088 360911000901 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 360911000902 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 360911000903 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 360911000904 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 360911000905 active site 360911000906 stage V sporulation protein K; Region: spore_V_K; TIGR02881 360911000907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000908 Walker A motif; other site 360911000909 ATP binding site [chemical binding]; other site 360911000910 Walker B motif; other site 360911000911 arginine finger; other site 360911000912 stage V sporulation protein K; Region: spore_V_K; TIGR02881 360911000913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000914 Walker A motif; other site 360911000915 ATP binding site [chemical binding]; other site 360911000916 Walker B motif; other site 360911000917 arginine finger; other site 360911000918 BCCT family transporter; Region: BCCT; cl00569 360911000919 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 360911000920 aconitate hydratase; Validated; Region: PRK09277 360911000921 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 360911000922 substrate binding site [chemical binding]; other site 360911000923 ligand binding site [chemical binding]; other site 360911000924 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 360911000925 substrate binding site [chemical binding]; other site 360911000926 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 360911000927 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 360911000928 G1 box; other site 360911000929 putative GEF interaction site [polypeptide binding]; other site 360911000930 GTP/Mg2+ binding site [chemical binding]; other site 360911000931 Switch I region; other site 360911000932 G2 box; other site 360911000933 G3 box; other site 360911000934 Switch II region; other site 360911000935 G4 box; other site 360911000936 G5 box; other site 360911000937 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 360911000938 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 360911000939 Protein of unknown function, DUF485; Region: DUF485; cl01231 360911000940 Sodium:solute symporter family; Region: SSF; cl00456 360911000941 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360911000942 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 360911000943 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 360911000944 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 360911000945 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 360911000946 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911000947 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 360911000948 Walker A/P-loop; other site 360911000949 ATP binding site [chemical binding]; other site 360911000950 Q-loop/lid; other site 360911000951 ABC transporter signature motif; other site 360911000952 Walker B; other site 360911000953 D-loop; other site 360911000954 H-loop/switch region; other site 360911000955 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911000956 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 360911000957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911000958 Walker A/P-loop; other site 360911000959 ATP binding site [chemical binding]; other site 360911000960 Q-loop/lid; other site 360911000961 ABC transporter signature motif; other site 360911000962 Walker B; other site 360911000963 D-loop; other site 360911000964 H-loop/switch region; other site 360911000965 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 360911000966 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 360911000967 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 360911000968 TPP-binding site [chemical binding]; other site 360911000969 dimer interface [polypeptide binding]; other site 360911000970 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 360911000971 PYR/PP interface [polypeptide binding]; other site 360911000972 dimer interface [polypeptide binding]; other site 360911000973 TPP binding site [chemical binding]; other site 360911000974 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911000975 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 360911000976 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 360911000977 catalytic residues [active] 360911000978 catalytic nucleophile [active] 360911000979 LexA repressor; Validated; Region: PRK00215 360911000980 Helix-turn-helix domains; Region: HTH; cl00088 360911000981 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 360911000982 Catalytic site [active] 360911000983 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 360911000984 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360911000985 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 360911000986 glutamine synthetase, type I; Region: GlnA; TIGR00653 360911000987 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 360911000988 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 360911000989 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 360911000990 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911000991 DNA binding residues [nucleotide binding] 360911000992 putative dimer interface [polypeptide binding]; other site 360911000993 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 360911000994 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911000995 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 360911000996 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 360911000997 HflX GTPase family; Region: HflX; cd01878 360911000998 G1 box; other site 360911000999 GTP/Mg2+ binding site [chemical binding]; other site 360911001000 Switch I region; other site 360911001001 G2 box; other site 360911001002 G3 box; other site 360911001003 Switch II region; other site 360911001004 G4 box; other site 360911001005 G5 box; other site 360911001006 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911001007 active site 360911001008 Int/Topo IB signature motif; other site 360911001009 DNA binding site [nucleotide binding] 360911001010 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 360911001011 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 360911001012 active site 360911001013 HIGH motif; other site 360911001014 KMSKS motif; other site 360911001015 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 360911001016 tRNA binding surface [nucleotide binding]; other site 360911001017 anticodon binding site; other site 360911001018 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360911001019 catalytic core [active] 360911001020 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911001021 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911001022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911001023 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911001024 putative substrate translocation pore; other site 360911001025 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 360911001026 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 360911001027 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 360911001028 substrate-cofactor binding pocket; other site 360911001029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001030 catalytic residue [active] 360911001031 Threonine dehydrogenase; Region: TDH; cd05281 360911001032 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 360911001033 structural Zn binding site [ion binding]; other site 360911001034 catalytic Zn binding site [ion binding]; other site 360911001035 tetramer interface [polypeptide binding]; other site 360911001036 NADP binding site [chemical binding]; other site 360911001037 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 360911001038 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 360911001039 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911001040 putative active site [active] 360911001041 metal binding site [ion binding]; metal-binding site 360911001042 homodimer binding site [polypeptide binding]; other site 360911001043 phosphodiesterase; Provisional; Region: PRK12704 360911001044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911001045 recombinase A; Provisional; Region: recA; PRK09354 360911001046 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 360911001047 hexamer interface [polypeptide binding]; other site 360911001048 Walker A motif; other site 360911001049 ATP binding site [chemical binding]; other site 360911001050 Walker B motif; other site 360911001051 competence damage-inducible protein A; Provisional; Region: PRK00549 360911001052 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 360911001053 putative MPT binding site; other site 360911001054 Competence-damaged protein; Region: CinA; cl00666 360911001055 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 360911001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 360911001057 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 360911001058 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 360911001059 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 360911001060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911001061 NAD(P) binding site [chemical binding]; other site 360911001062 active site 360911001063 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 360911001064 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 360911001065 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360911001066 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 360911001067 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360911001068 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 360911001069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 360911001070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911001071 dimerization interface [polypeptide binding]; other site 360911001072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911001073 dimer interface [polypeptide binding]; other site 360911001074 phosphorylation site [posttranslational modification] 360911001075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911001076 ATP binding site [chemical binding]; other site 360911001077 Mg2+ binding site [ion binding]; other site 360911001078 G-X-G motif; other site 360911001079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911001080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001081 active site 360911001082 phosphorylation site [posttranslational modification] 360911001083 intermolecular recognition site; other site 360911001084 dimerization interface [polypeptide binding]; other site 360911001085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911001086 DNA binding site [nucleotide binding] 360911001087 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 360911001088 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 360911001089 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 360911001090 ResB-like family; Region: ResB; pfam05140 360911001091 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 360911001092 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 360911001093 catalytic residues [active] 360911001094 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 360911001095 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911001096 RNA binding surface [nucleotide binding]; other site 360911001097 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 360911001098 active site 360911001099 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 360911001100 ScpA/B protein; Region: ScpA_ScpB; cl00598 360911001101 Domain of unknown function (DUF309); Region: DUF309; cl00667 360911001102 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 360911001103 active site 360911001104 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 360911001105 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 360911001106 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 360911001107 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 360911001108 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 360911001109 Sulfatase; Region: Sulfatase; cl10460 360911001110 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 360911001111 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 360911001112 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 360911001113 active site 360911001114 Int/Topo IB signature motif; other site 360911001115 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 360911001116 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 360911001117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911001118 putative substrate translocation pore; other site 360911001119 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 360911001120 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911001121 putative metal binding site [ion binding]; other site 360911001122 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360911001123 metal binding site 2 [ion binding]; metal-binding site 360911001124 putative DNA binding helix; other site 360911001125 metal binding site 1 [ion binding]; metal-binding site 360911001126 dimer interface [polypeptide binding]; other site 360911001127 structural Zn2+ binding site [ion binding]; other site 360911001128 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 360911001129 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 360911001130 dimer interface [polypeptide binding]; other site 360911001131 ADP-ribose binding site [chemical binding]; other site 360911001132 active site 360911001133 nudix motif; other site 360911001134 metal binding site [ion binding]; metal-binding site 360911001135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911001136 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911001137 active site 360911001138 catalytic tetrad [active] 360911001139 Helix-turn-helix domains; Region: HTH; cl00088 360911001140 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 360911001141 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911001142 catalytic residues [active] 360911001143 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 360911001144 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 360911001145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911001146 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 360911001147 Walker A/P-loop; other site 360911001148 ATP binding site [chemical binding]; other site 360911001149 Q-loop/lid; other site 360911001150 ABC transporter signature motif; other site 360911001151 Walker B; other site 360911001152 D-loop; other site 360911001153 H-loop/switch region; other site 360911001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001155 dimer interface [polypeptide binding]; other site 360911001156 conserved gate region; other site 360911001157 putative PBP binding loops; other site 360911001158 ABC-ATPase subunit interface; other site 360911001159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001160 dimer interface [polypeptide binding]; other site 360911001161 conserved gate region; other site 360911001162 putative PBP binding loops; other site 360911001163 ABC-ATPase subunit interface; other site 360911001164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911001165 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 360911001166 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 360911001167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911001168 NAD(P) binding site [chemical binding]; other site 360911001169 active site 360911001170 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 360911001171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911001172 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 360911001173 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 360911001174 tetrameric interface [polypeptide binding]; other site 360911001175 activator binding site; other site 360911001176 NADP binding site [chemical binding]; other site 360911001177 substrate binding site [chemical binding]; other site 360911001178 catalytic residues [active] 360911001179 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 360911001180 Response regulator receiver domain; Region: Response_reg; pfam00072 360911001181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001182 active site 360911001183 phosphorylation site [posttranslational modification] 360911001184 intermolecular recognition site; other site 360911001185 dimerization interface [polypeptide binding]; other site 360911001186 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 360911001187 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 360911001188 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 360911001189 Response regulator receiver domain; Region: Response_reg; pfam00072 360911001190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001191 active site 360911001192 phosphorylation site [posttranslational modification] 360911001193 intermolecular recognition site; other site 360911001194 dimerization interface [polypeptide binding]; other site 360911001195 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 360911001196 DNA topoisomerase III; Provisional; Region: PRK07726 360911001197 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 360911001198 active site 360911001199 putative interdomain interaction site [polypeptide binding]; other site 360911001200 putative metal-binding site [ion binding]; other site 360911001201 putative nucleotide binding site [chemical binding]; other site 360911001202 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 360911001203 domain I; other site 360911001204 DNA binding groove [nucleotide binding] 360911001205 phosphate binding site [ion binding]; other site 360911001206 domain II; other site 360911001207 domain III; other site 360911001208 nucleotide binding site [chemical binding]; other site 360911001209 catalytic site [active] 360911001210 domain IV; other site 360911001211 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911001212 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 360911001213 EamA-like transporter family; Region: EamA; cl01037 360911001214 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 360911001215 EamA-like transporter family; Region: EamA; cl01037 360911001216 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 360911001217 MatE; Region: MatE; cl10513 360911001218 MatE; Region: MatE; cl10513 360911001219 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 360911001220 Peptidase family U32; Region: Peptidase_U32; cl03113 360911001221 Peptidase family U32; Region: Peptidase_U32; cl03113 360911001222 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 360911001223 classical (c) SDRs; Region: SDR_c; cd05233 360911001224 NAD(P) binding site [chemical binding]; other site 360911001225 active site 360911001226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911001227 ABC transporter signature motif; other site 360911001228 Walker B; other site 360911001229 D-loop; other site 360911001230 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911001231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911001232 Walker A/P-loop; other site 360911001233 ATP binding site [chemical binding]; other site 360911001234 Q-loop/lid; other site 360911001235 ABC transporter signature motif; other site 360911001236 Walker B; other site 360911001237 D-loop; other site 360911001238 H-loop/switch region; other site 360911001239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911001240 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 360911001241 peptidase T-like protein; Region: PepT-like; TIGR01883 360911001242 metal binding site [ion binding]; metal-binding site 360911001243 putative dimer interface [polypeptide binding]; other site 360911001244 Predicted membrane protein [Function unknown]; Region: COG4129 360911001245 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 360911001246 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 360911001247 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 360911001248 short chain dehydrogenase; Provisional; Region: PRK07677 360911001249 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 360911001250 NAD(P) binding site [chemical binding]; other site 360911001251 substrate binding site [chemical binding]; other site 360911001252 homotetramer interface [polypeptide binding]; other site 360911001253 active site 360911001254 homodimer interface [polypeptide binding]; other site 360911001255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911001256 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 360911001257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911001258 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 360911001259 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 360911001260 Walker A/P-loop; other site 360911001261 ATP binding site [chemical binding]; other site 360911001262 Q-loop/lid; other site 360911001263 ABC transporter signature motif; other site 360911001264 Walker B; other site 360911001265 D-loop; other site 360911001266 H-loop/switch region; other site 360911001267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360911001268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001269 dimer interface [polypeptide binding]; other site 360911001270 conserved gate region; other site 360911001271 putative PBP binding loops; other site 360911001272 ABC-ATPase subunit interface; other site 360911001273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911001274 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911001275 substrate binding pocket [chemical binding]; other site 360911001276 membrane-bound complex binding site; other site 360911001277 hinge residues; other site 360911001278 Protein of unknown function (DUF952); Region: DUF952; cl01393 360911001279 Disulphide isomerase; Region: Disulph_isomer; pfam06491 360911001280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001281 S-adenosylmethionine binding site [chemical binding]; other site 360911001282 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 360911001283 SpoOM protein; Region: Spo0M; pfam07070 360911001284 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 360911001285 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360911001286 E3 interaction surface; other site 360911001287 lipoyl attachment site [posttranslational modification]; other site 360911001288 e3 binding domain; Region: E3_binding; pfam02817 360911001289 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 360911001290 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 360911001291 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 360911001292 alpha subunit interface [polypeptide binding]; other site 360911001293 TPP binding site [chemical binding]; other site 360911001294 heterodimer interface [polypeptide binding]; other site 360911001295 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911001296 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 360911001297 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 360911001298 tetramer interface [polypeptide binding]; other site 360911001299 TPP-binding site [chemical binding]; other site 360911001300 heterodimer interface [polypeptide binding]; other site 360911001301 phosphorylation loop region [posttranslational modification] 360911001302 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 360911001303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911001304 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911001305 Acetokinase family; Region: Acetate_kinase; cl01029 360911001306 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 360911001307 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 360911001308 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 360911001309 NAD binding site [chemical binding]; other site 360911001310 Phe binding site; other site 360911001311 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 360911001312 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 360911001313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911001314 PAS domain S-box; Region: sensory_box; TIGR00229 360911001315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 360911001316 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 360911001317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911001318 Walker A motif; other site 360911001319 ATP binding site [chemical binding]; other site 360911001320 Walker B motif; other site 360911001321 arginine finger; other site 360911001322 Helix-turn-helix domains; Region: HTH; cl00088 360911001323 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 360911001324 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 360911001325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001326 active site 360911001327 phosphorylation site [posttranslational modification] 360911001328 intermolecular recognition site; other site 360911001329 dimerization interface [polypeptide binding]; other site 360911001330 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 360911001331 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 360911001332 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 360911001333 Walker A/P-loop; other site 360911001334 ATP binding site [chemical binding]; other site 360911001335 Q-loop/lid; other site 360911001336 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 360911001337 ABC transporter signature motif; other site 360911001338 Walker B; other site 360911001339 D-loop; other site 360911001340 H-loop/switch region; other site 360911001341 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 360911001342 arginine repressor; Provisional; Region: PRK04280 360911001343 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 360911001344 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 360911001345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 360911001346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 360911001347 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 360911001348 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 360911001349 TPP-binding site; other site 360911001350 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 360911001351 PYR/PP interface [polypeptide binding]; other site 360911001352 dimer interface [polypeptide binding]; other site 360911001353 TPP binding site [chemical binding]; other site 360911001354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911001355 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 360911001356 substrate binding pocket [chemical binding]; other site 360911001357 chain length determination region; other site 360911001358 substrate-Mg2+ binding site; other site 360911001359 catalytic residues [active] 360911001360 aspartate-rich region 1; other site 360911001361 active site lid residues [active] 360911001362 aspartate-rich region 2; other site 360911001363 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 360911001364 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 360911001365 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 360911001366 generic binding surface II; other site 360911001367 generic binding surface I; other site 360911001368 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 360911001369 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 360911001370 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 360911001371 homodimer interface [polypeptide binding]; other site 360911001372 NADP binding site [chemical binding]; other site 360911001373 substrate binding site [chemical binding]; other site 360911001374 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 360911001375 putative RNA binding site [nucleotide binding]; other site 360911001376 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 360911001377 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911001378 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 360911001379 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 360911001380 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 360911001381 carboxyltransferase (CT) interaction site; other site 360911001382 biotinylation site [posttranslational modification]; other site 360911001383 elongation factor P; Validated; Region: PRK00529 360911001384 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 360911001385 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 360911001386 RNA binding site [nucleotide binding]; other site 360911001387 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 360911001388 RNA binding site [nucleotide binding]; other site 360911001389 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 360911001390 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 360911001391 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 360911001392 active site 360911001393 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 360911001394 active site 360911001395 trimer interface [polypeptide binding]; other site 360911001396 dimer interface [polypeptide binding]; other site 360911001397 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 360911001398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911001399 active site 360911001400 manganese transport transcriptional regulator; Provisional; Region: PRK03902 360911001401 Helix-turn-helix domains; Region: HTH; cl00088 360911001402 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 360911001403 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911001404 active site residue [active] 360911001405 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 360911001406 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 360911001407 tetramer interface [polypeptide binding]; other site 360911001408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001409 catalytic residue [active] 360911001410 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 360911001411 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 360911001412 tetramer interface [polypeptide binding]; other site 360911001413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001414 catalytic residue [active] 360911001415 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 360911001416 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 360911001417 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 360911001418 shikimate kinase; Reviewed; Region: aroK; PRK00131 360911001419 ADP binding site [chemical binding]; other site 360911001420 magnesium binding site [ion binding]; other site 360911001421 putative shikimate binding site; other site 360911001422 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 360911001423 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 360911001424 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 360911001425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911001426 Walker A motif; other site 360911001427 ATP binding site [chemical binding]; other site 360911001428 Walker B motif; other site 360911001429 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 360911001430 ArsC family; Region: ArsC; pfam03960 360911001431 putative catalytic residues [active] 360911001432 thiol/disulfide switch; other site 360911001433 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 360911001434 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911001435 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 360911001436 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 360911001437 Sulfatase; Region: Sulfatase; cl10460 360911001438 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 360911001439 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 360911001440 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 360911001441 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 360911001442 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 360911001443 putative oligomer interface [polypeptide binding]; other site 360911001444 putative active site [active] 360911001445 metal binding site [ion binding]; metal-binding site 360911001446 Rhomboid family; Region: Rhomboid; cl11446 360911001447 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 360911001448 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 360911001449 dimer interface [polypeptide binding]; other site 360911001450 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911001451 NAD binding site [chemical binding]; other site 360911001452 substrate binding site [chemical binding]; other site 360911001453 Integral membrane protein DUF92; Region: DUF92; cl00793 360911001454 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 360911001455 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 360911001456 Uncharacterized conserved protein [Function unknown]; Region: COG1543 360911001457 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 360911001458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911001459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 360911001460 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 360911001461 PhoU domain; Region: PhoU; pfam01895 360911001462 PhoU domain; Region: PhoU; pfam01895 360911001463 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 360911001464 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 360911001465 Walker A/P-loop; other site 360911001466 ATP binding site [chemical binding]; other site 360911001467 Q-loop/lid; other site 360911001468 ABC transporter signature motif; other site 360911001469 Walker B; other site 360911001470 D-loop; other site 360911001471 H-loop/switch region; other site 360911001472 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 360911001473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001474 dimer interface [polypeptide binding]; other site 360911001475 conserved gate region; other site 360911001476 putative PBP binding loops; other site 360911001477 ABC-ATPase subunit interface; other site 360911001478 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 360911001479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001480 dimer interface [polypeptide binding]; other site 360911001481 conserved gate region; other site 360911001482 putative PBP binding loops; other site 360911001483 ABC-ATPase subunit interface; other site 360911001484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911001485 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 360911001486 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360911001487 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360911001488 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911001489 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 360911001490 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 360911001491 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 360911001492 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 360911001493 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 360911001494 active site 360911001495 Na/Ca binding site [ion binding]; other site 360911001496 catalytic site [active] 360911001497 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 360911001498 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911001499 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911001500 PhoU domain; Region: PhoU; pfam01895 360911001501 PhoU domain; Region: PhoU; pfam01895 360911001502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911001503 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911001504 dimer interface [polypeptide binding]; other site 360911001505 putative CheW interface [polypeptide binding]; other site 360911001506 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 360911001507 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 360911001508 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 360911001509 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911001510 putative carbohydrate kinase; Provisional; Region: PRK10565 360911001511 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 360911001512 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 360911001513 putative substrate binding site [chemical binding]; other site 360911001514 putative ATP binding site [chemical binding]; other site 360911001515 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360911001516 metal binding site 2 [ion binding]; metal-binding site 360911001517 putative DNA binding helix; other site 360911001518 metal binding site 1 [ion binding]; metal-binding site 360911001519 dimer interface [polypeptide binding]; other site 360911001520 structural Zn2+ binding site [ion binding]; other site 360911001521 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911001522 ABC-ATPase subunit interface; other site 360911001523 dimer interface [polypeptide binding]; other site 360911001524 putative PBP binding regions; other site 360911001525 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911001526 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 360911001527 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 360911001528 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 360911001529 polyphosphate kinase; Provisional; Region: PRK05443 360911001530 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 360911001531 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 360911001532 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 360911001533 putative domain interface [polypeptide binding]; other site 360911001534 putative active site [active] 360911001535 catalytic site [active] 360911001536 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 360911001537 putative domain interface [polypeptide binding]; other site 360911001538 putative active site [active] 360911001539 catalytic site [active] 360911001540 endonuclease IV; Provisional; Region: PRK01060 360911001541 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 360911001542 AP (apurinic/apyrimidinic) site pocket; other site 360911001543 DNA interaction; other site 360911001544 Metal-binding active site; metal-binding site 360911001545 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911001546 DEAD-like helicases superfamily; Region: DEXDc; smart00487 360911001547 ATP binding site [chemical binding]; other site 360911001548 Mg++ binding site [ion binding]; other site 360911001549 motif III; other site 360911001550 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911001551 nucleotide binding region [chemical binding]; other site 360911001552 ATP-binding site [chemical binding]; other site 360911001553 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 360911001554 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360911001555 ligand binding site [chemical binding]; other site 360911001556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911001557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911001558 dimer interface [polypeptide binding]; other site 360911001559 phosphorylation site [posttranslational modification] 360911001560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911001561 ATP binding site [chemical binding]; other site 360911001562 Mg2+ binding site [ion binding]; other site 360911001563 G-X-G motif; other site 360911001564 LytB protein; Region: LYTB; cl00507 360911001565 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 360911001566 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 360911001567 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 360911001568 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 360911001569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911001570 Cytochrome c; Region: Cytochrom_C; cl11414 360911001571 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 360911001572 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 360911001573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911001574 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360911001575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911001576 DNA binding residues [nucleotide binding] 360911001577 DNA primase; Validated; Region: dnaG; PRK05667 360911001578 CHC2 zinc finger; Region: zf-CHC2; cl15369 360911001579 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 360911001580 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 360911001581 active site 360911001582 metal binding site [ion binding]; metal-binding site 360911001583 interdomain interaction site; other site 360911001584 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 360911001585 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 360911001586 Helix-turn-helix domains; Region: HTH; cl00088 360911001587 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 360911001588 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 360911001589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911001590 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 360911001591 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 360911001592 dimer interface [polypeptide binding]; other site 360911001593 motif 1; other site 360911001594 active site 360911001595 motif 2; other site 360911001596 motif 3; other site 360911001597 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 360911001598 Recombination protein O N terminal; Region: RecO_N; cl15812 360911001599 Recombination protein O C terminal; Region: RecO_C; pfam02565 360911001600 GTPase Era; Reviewed; Region: era; PRK00089 360911001601 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 360911001602 G1 box; other site 360911001603 GTP/Mg2+ binding site [chemical binding]; other site 360911001604 Switch I region; other site 360911001605 G2 box; other site 360911001606 Switch II region; other site 360911001607 G3 box; other site 360911001608 G4 box; other site 360911001609 G5 box; other site 360911001610 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 360911001611 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 360911001612 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 360911001613 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 360911001614 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 360911001615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911001616 Zn2+ binding site [ion binding]; other site 360911001617 Mg2+ binding site [ion binding]; other site 360911001618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911001619 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 360911001620 GatB domain; Region: GatB_Yqey; cl11497 360911001621 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 360911001622 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 360911001623 intersubunit interface [polypeptide binding]; other site 360911001624 active site 360911001625 catalytic residue [active] 360911001626 Predicted permeases [General function prediction only]; Region: RarD; COG2962 360911001627 EamA-like transporter family; Region: EamA; cl01037 360911001628 cystathionine beta-lyase; Provisional; Region: PRK07671 360911001629 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 360911001630 homodimer interface [polypeptide binding]; other site 360911001631 substrate-cofactor binding pocket; other site 360911001632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001633 catalytic residue [active] 360911001634 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 360911001635 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 360911001636 dimer interface [polypeptide binding]; other site 360911001637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001638 catalytic residue [active] 360911001639 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 360911001640 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 360911001641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001642 S-adenosylmethionine binding site [chemical binding]; other site 360911001643 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 360911001644 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 360911001645 putative active site [active] 360911001646 catalytic triad [active] 360911001647 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 360911001648 PA/protease or protease-like domain interface [polypeptide binding]; other site 360911001649 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 360911001650 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 360911001651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 360911001652 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 360911001653 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 360911001654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001655 S-adenosylmethionine binding site [chemical binding]; other site 360911001656 chaperone protein DnaJ; Provisional; Region: PRK14280 360911001657 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 360911001658 HSP70 interaction site [polypeptide binding]; other site 360911001659 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 360911001660 Zn binding sites [ion binding]; other site 360911001661 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 360911001662 dimer interface [polypeptide binding]; other site 360911001663 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 360911001664 heat shock protein GrpE; Provisional; Region: PRK14140 360911001665 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 360911001666 dimer interface [polypeptide binding]; other site 360911001667 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 360911001668 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 360911001669 Helix-turn-helix domains; Region: HTH; cl00088 360911001670 HrcA protein C terminal domain; Region: HrcA; pfam01628 360911001671 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 360911001672 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 360911001673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911001674 FeS/SAM binding site; other site 360911001675 HemN C-terminal domain; Region: HemN_C; pfam06969 360911001676 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 360911001677 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 360911001678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911001679 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 360911001680 L-serine binding site [chemical binding]; other site 360911001681 ACT domain interface; other site 360911001682 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911001683 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911001684 catalytic residue [active] 360911001685 GTP-binding protein LepA; Provisional; Region: PRK05433 360911001686 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 360911001687 G1 box; other site 360911001688 putative GEF interaction site [polypeptide binding]; other site 360911001689 GTP/Mg2+ binding site [chemical binding]; other site 360911001690 Switch I region; other site 360911001691 G2 box; other site 360911001692 G3 box; other site 360911001693 Switch II region; other site 360911001694 G4 box; other site 360911001695 G5 box; other site 360911001696 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 360911001697 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 360911001698 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 360911001699 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 360911001700 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911001701 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 360911001702 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 360911001703 YqzM-like protein; Region: YqzM; pfam14141 360911001704 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 360911001705 Competence protein; Region: Competence; cl00471 360911001706 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911001707 SLBB domain; Region: SLBB; pfam10531 360911001708 comEA protein; Region: comE; TIGR01259 360911001709 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 360911001710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911001711 dimerization interface [polypeptide binding]; other site 360911001712 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911001713 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911001714 dimer interface [polypeptide binding]; other site 360911001715 putative CheW interface [polypeptide binding]; other site 360911001716 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 360911001717 ligand binding site [chemical binding]; other site 360911001718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 360911001719 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 360911001720 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 360911001721 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 360911001722 ribonuclease HIII; Provisional; Region: PRK00996 360911001723 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 360911001724 RNA/DNA hybrid binding site [nucleotide binding]; other site 360911001725 active site 360911001726 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911001727 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911001728 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 360911001729 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 360911001730 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 360911001731 putative tRNA-binding site [nucleotide binding]; other site 360911001732 B3/4 domain; Region: B3_4; cl11458 360911001733 tRNA synthetase B5 domain; Region: B5; cl08394 360911001734 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 360911001735 dimer interface [polypeptide binding]; other site 360911001736 motif 1; other site 360911001737 motif 3; other site 360911001738 motif 2; other site 360911001739 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 360911001740 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 360911001741 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 360911001742 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 360911001743 dimer interface [polypeptide binding]; other site 360911001744 motif 1; other site 360911001745 active site 360911001746 motif 2; other site 360911001747 motif 3; other site 360911001748 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 360911001749 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 360911001750 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 360911001751 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 360911001752 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 360911001753 oligomer interface [polypeptide binding]; other site 360911001754 active site 360911001755 metal binding site [ion binding]; metal-binding site 360911001756 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 360911001757 dUTPase; Region: dUTPase_2; pfam08761 360911001758 ribosomal protein L20; Region: rpl20; CHL00068 360911001759 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 360911001760 23S rRNA binding site [nucleotide binding]; other site 360911001761 L21 binding site [polypeptide binding]; other site 360911001762 L13 binding site [polypeptide binding]; other site 360911001763 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 360911001764 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 360911001765 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 360911001766 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 360911001767 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 360911001768 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 360911001769 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 360911001770 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 360911001771 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 360911001772 active site 360911001773 dimer interface [polypeptide binding]; other site 360911001774 motif 1; other site 360911001775 motif 2; other site 360911001776 motif 3; other site 360911001777 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 360911001778 anticodon binding site; other site 360911001779 primosomal protein DnaI; Reviewed; Region: PRK08939 360911001780 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 360911001781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911001782 Walker A motif; other site 360911001783 ATP binding site [chemical binding]; other site 360911001784 Walker B motif; other site 360911001785 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 360911001786 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 360911001787 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 360911001788 ATP cone domain; Region: ATP-cone; pfam03477 360911001789 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 360911001790 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 360911001791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911001792 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 360911001793 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 360911001794 active site 360911001795 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 360911001796 dephospho-CoA kinase; Region: TIGR00152 360911001797 CoA-binding site [chemical binding]; other site 360911001798 ATP-binding [chemical binding]; other site 360911001799 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 360911001800 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 360911001801 DNA binding site [nucleotide binding] 360911001802 catalytic residue [active] 360911001803 H2TH interface [polypeptide binding]; other site 360911001804 putative catalytic residues [active] 360911001805 turnover-facilitating residue; other site 360911001806 intercalation triad [nucleotide binding]; other site 360911001807 8OG recognition residue [nucleotide binding]; other site 360911001808 putative reading head residues; other site 360911001809 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 360911001810 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 360911001811 DNA polymerase I; Provisional; Region: PRK05755 360911001812 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360911001813 active site 360911001814 metal binding site 1 [ion binding]; metal-binding site 360911001815 putative 5' ssDNA interaction site; other site 360911001816 metal binding site 3; metal-binding site 360911001817 metal binding site 2 [ion binding]; metal-binding site 360911001818 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360911001819 putative DNA binding site [nucleotide binding]; other site 360911001820 putative metal binding site [ion binding]; other site 360911001821 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 360911001822 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 360911001823 active site 360911001824 DNA binding site [nucleotide binding] 360911001825 catalytic site [active] 360911001826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911001827 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 360911001828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 360911001829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911001830 dimer interface [polypeptide binding]; other site 360911001831 phosphorylation site [posttranslational modification] 360911001832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911001833 ATP binding site [chemical binding]; other site 360911001834 Mg2+ binding site [ion binding]; other site 360911001835 G-X-G motif; other site 360911001836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911001837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001838 active site 360911001839 phosphorylation site [posttranslational modification] 360911001840 intermolecular recognition site; other site 360911001841 dimerization interface [polypeptide binding]; other site 360911001842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911001843 DNA binding site [nucleotide binding] 360911001844 malate dehydrogenase; Reviewed; Region: PRK06223 360911001845 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 360911001846 NAD(P) binding site [chemical binding]; other site 360911001847 dimer interface [polypeptide binding]; other site 360911001848 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911001849 substrate binding site [chemical binding]; other site 360911001850 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 360911001851 isocitrate dehydrogenase; Validated; Region: PRK07362 360911001852 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 360911001853 dimer interface [polypeptide binding]; other site 360911001854 Citrate synthase; Region: Citrate_synt; pfam00285 360911001855 active site 360911001856 citrylCoA binding site [chemical binding]; other site 360911001857 oxalacetate/citrate binding site [chemical binding]; other site 360911001858 coenzyme A binding site [chemical binding]; other site 360911001859 catalytic triad [active] 360911001860 Protein of unknown function (DUF441); Region: DUF441; cl01041 360911001861 pyruvate kinase; Provisional; Region: PRK06354 360911001862 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 360911001863 domain interfaces; other site 360911001864 active site 360911001865 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 360911001866 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 360911001867 active site 360911001868 ADP/pyrophosphate binding site [chemical binding]; other site 360911001869 dimerization interface [polypeptide binding]; other site 360911001870 allosteric effector site; other site 360911001871 fructose-1,6-bisphosphate binding site; other site 360911001872 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 360911001873 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 360911001874 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 360911001875 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 360911001876 Transcriptional regulators [Transcription]; Region: FadR; COG2186 360911001877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911001878 DNA-binding site [nucleotide binding]; DNA binding site 360911001879 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 360911001880 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 360911001881 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 360911001882 generic binding surface I; other site 360911001883 generic binding surface II; other site 360911001884 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 360911001885 DHH family; Region: DHH; pfam01368 360911001886 DHHA1 domain; Region: DHHA1; pfam02272 360911001887 YtpI-like protein; Region: YtpI; pfam14007 360911001888 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 360911001889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911001890 DNA-binding site [nucleotide binding]; DNA binding site 360911001891 DRTGG domain; Region: DRTGG; cl12147 360911001892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 360911001893 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 360911001894 active site 2 [active] 360911001895 active site 1 [active] 360911001896 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 360911001897 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 360911001898 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 360911001899 active site 360911001900 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911001901 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 360911001902 active site 360911001903 metal binding site [ion binding]; metal-binding site 360911001904 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 360911001905 classical (c) SDRs; Region: SDR_c; cd05233 360911001906 NAD(P) binding site [chemical binding]; other site 360911001907 active site 360911001908 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 360911001909 Ligand Binding Site [chemical binding]; other site 360911001910 Bacterial SH3 domain; Region: SH3_3; cl02551 360911001911 3D domain; Region: 3D; cl01439 360911001912 Acetokinase family; Region: Acetate_kinase; cl01029 360911001913 propionate/acetate kinase; Provisional; Region: PRK12379 360911001914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001915 S-adenosylmethionine binding site [chemical binding]; other site 360911001916 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 360911001917 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 360911001918 dimer interface [polypeptide binding]; other site 360911001919 catalytic triad [active] 360911001920 peroxidatic and resolving cysteines [active] 360911001921 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 360911001922 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 360911001923 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 360911001924 active site 360911001925 septation ring formation regulator EzrA; Provisional; Region: PRK04778 360911001926 GAF domain; Region: GAF; cl15785 360911001927 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 360911001928 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 360911001929 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911001930 RNA binding surface [nucleotide binding]; other site 360911001931 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911001932 synthetase active site [active] 360911001933 NTP binding site [chemical binding]; other site 360911001934 metal binding site [ion binding]; metal-binding site 360911001935 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 360911001936 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 360911001937 active site 360911001938 HIGH motif; other site 360911001939 dimer interface [polypeptide binding]; other site 360911001940 KMSKS motif; other site 360911001941 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911001942 RNA binding surface [nucleotide binding]; other site 360911001943 Transglycosylase; Region: Transgly; cl07896 360911001944 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 360911001945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911001946 acetyl-CoA synthetase; Provisional; Region: PRK04319 360911001947 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 360911001948 AMP-binding enzyme; Region: AMP-binding; cl15778 360911001949 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911001950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911001951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911001952 Coenzyme A binding pocket [chemical binding]; other site 360911001953 FOG: CBS domain [General function prediction only]; Region: COG0517 360911001954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 360911001955 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 360911001956 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 360911001957 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 360911001958 catabolite control protein A; Region: ccpA; TIGR01481 360911001959 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911001960 DNA binding site [nucleotide binding] 360911001961 domain linker motif; other site 360911001962 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 360911001963 dimerization interface [polypeptide binding]; other site 360911001964 effector binding site; other site 360911001965 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 360911001966 Chorismate mutase type II; Region: CM_2; cl00693 360911001967 NeuB family; Region: NeuB; cl00496 360911001968 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 360911001969 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 360911001970 Ferritin-like domain; Region: Ferritin; pfam00210 360911001971 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 360911001972 dimerization interface [polypeptide binding]; other site 360911001973 DPS ferroxidase diiron center [ion binding]; other site 360911001974 ion pore; other site 360911001975 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 360911001976 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911001977 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911001978 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911001979 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 360911001980 putative tRNA-binding site [nucleotide binding]; other site 360911001981 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 360911001982 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911001983 catalytic residues [active] 360911001984 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911001985 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 360911001986 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 360911001987 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 360911001988 oligomer interface [polypeptide binding]; other site 360911001989 active site 360911001990 metal binding site [ion binding]; metal-binding site 360911001991 Predicted small secreted protein [Function unknown]; Region: COG5584 360911001992 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 360911001993 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 360911001994 DAK2 domain; Region: Dak2; cl03685 360911001995 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 360911001996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001997 S-adenosylmethionine binding site [chemical binding]; other site 360911001998 Phosphotransferase enzyme family; Region: APH; pfam01636 360911001999 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 360911002000 active site 360911002001 substrate binding site [chemical binding]; other site 360911002002 ATP binding site [chemical binding]; other site 360911002003 pullulanase, type I; Region: pulA_typeI; TIGR02104 360911002004 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 360911002005 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 360911002006 Ca binding site [ion binding]; other site 360911002007 active site 360911002008 catalytic site [active] 360911002009 Restriction endonuclease; Region: Mrr_cat; cl00516 360911002010 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 360911002011 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 360911002012 sugar efflux transporter; Region: 2A0120; TIGR00899 360911002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002014 putative substrate translocation pore; other site 360911002015 dipeptidase PepV; Reviewed; Region: PRK07318 360911002016 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 360911002017 active site 360911002018 metal binding site [ion binding]; metal-binding site 360911002019 Helix-turn-helix domains; Region: HTH; cl00088 360911002020 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 360911002021 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 360911002022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911002023 RNA binding surface [nucleotide binding]; other site 360911002024 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 360911002025 active site 360911002026 uracil binding [chemical binding]; other site 360911002027 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 360911002028 MatE; Region: MatE; cl10513 360911002029 MatE; Region: MatE; cl10513 360911002030 HI0933-like protein; Region: HI0933_like; pfam03486 360911002031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002033 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 360911002034 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 360911002035 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 360911002036 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 360911002037 HIGH motif; other site 360911002038 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 360911002039 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360911002040 active site 360911002041 KMSKS motif; other site 360911002042 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 360911002043 tRNA binding surface [nucleotide binding]; other site 360911002044 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 360911002045 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 360911002046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911002048 putative substrate translocation pore; other site 360911002049 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 360911002050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002052 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911002053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911002054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002055 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911002056 Coenzyme A binding pocket [chemical binding]; other site 360911002057 S-adenosylmethionine synthetase; Validated; Region: PRK05250 360911002058 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 360911002059 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 360911002060 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 360911002061 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 360911002062 active site 360911002063 substrate-binding site [chemical binding]; other site 360911002064 metal-binding site [ion binding] 360911002065 ATP binding site [chemical binding]; other site 360911002066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911002067 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911002068 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 360911002069 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 360911002070 nudix motif; other site 360911002071 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 360911002072 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 360911002073 active site 360911002074 dimer interface [polypeptide binding]; other site 360911002075 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 360911002076 dimer interface [polypeptide binding]; other site 360911002077 active site 360911002078 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 360911002079 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 360911002080 dimer interface [polypeptide binding]; other site 360911002081 active site 360911002082 metal binding site [ion binding]; metal-binding site 360911002083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911002084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002085 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 360911002086 general stress protein 13; Validated; Region: PRK08059 360911002087 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 360911002088 RNA binding site [nucleotide binding]; other site 360911002089 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 360911002090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002091 hypothetical protein; Validated; Region: PRK07682 360911002092 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911002093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911002094 homodimer interface [polypeptide binding]; other site 360911002095 catalytic residue [active] 360911002096 Helix-turn-helix domains; Region: HTH; cl00088 360911002097 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911002098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911002099 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 360911002100 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 360911002101 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 360911002102 Class I ribonucleotide reductase; Region: RNR_I; cd01679 360911002103 active site 360911002104 dimer interface [polypeptide binding]; other site 360911002105 catalytic residues [active] 360911002106 effector binding site; other site 360911002107 R2 peptide binding site; other site 360911002108 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911002109 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 360911002110 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 360911002111 dimer interface [polypeptide binding]; other site 360911002112 putative radical transfer pathway; other site 360911002113 diiron center [ion binding]; other site 360911002114 tyrosyl radical; other site 360911002115 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002116 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002117 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002118 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 360911002119 active site 360911002120 metal binding site [ion binding]; metal-binding site 360911002121 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 360911002122 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 360911002123 Protein of unknown function (DUF429); Region: DUF429; cl12046 360911002124 multifunctional aminopeptidase A; Provisional; Region: PRK00913 360911002125 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 360911002126 interface (dimer of trimers) [polypeptide binding]; other site 360911002127 Substrate-binding/catalytic site; other site 360911002128 Zn-binding sites [ion binding]; other site 360911002129 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 360911002130 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 360911002131 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 360911002132 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 360911002133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911002134 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911002135 active site 360911002136 catalytic tetrad [active] 360911002137 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 360911002138 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911002139 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911002140 active site turn [active] 360911002141 phosphorylation site [posttranslational modification] 360911002142 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911002143 HPr interaction site; other site 360911002144 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911002145 active site 360911002146 phosphorylation site [posttranslational modification] 360911002147 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911002148 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 360911002149 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911002150 active site turn [active] 360911002151 phosphorylation site [posttranslational modification] 360911002152 CAT RNA binding domain; Region: CAT_RBD; cl03904 360911002153 transcriptional antiterminator BglG; Provisional; Region: PRK09772 360911002154 PRD domain; Region: PRD; cl15445 360911002155 PRD domain; Region: PRD; cl15445 360911002156 Putative membrane protein; Region: YuiB; pfam14068 360911002157 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 360911002158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002159 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 360911002160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002163 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 360911002164 NAD(P) binding site [chemical binding]; other site 360911002165 active site 360911002166 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 360911002167 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 360911002168 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 360911002169 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 360911002170 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 360911002171 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 360911002172 Nucleoside recognition; Region: Gate; cl00486 360911002173 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 360911002174 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 360911002175 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 360911002176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002177 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 360911002178 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 360911002179 active site 360911002180 catalytic residues [active] 360911002181 MG2 domain; Region: A2M_N; pfam01835 360911002182 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 360911002183 heme-binding site [chemical binding]; other site 360911002184 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911002185 dimer interface [polypeptide binding]; other site 360911002186 putative CheW interface [polypeptide binding]; other site 360911002187 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 360911002188 NifU-like domain; Region: NifU; cl00484 360911002189 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 360911002190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002191 active site 360911002192 motif I; other site 360911002193 motif II; other site 360911002194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002195 Protein of unknown function DUF86; Region: DUF86; cl01031 360911002196 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 360911002197 putative active site [active] 360911002198 Protein of unknown function (DUF975); Region: DUF975; cl10504 360911002199 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 360911002200 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 360911002201 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 360911002202 active site 360911002203 metal binding site [ion binding]; metal-binding site 360911002204 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360911002205 Protein of unknown function DUF72; Region: DUF72; cl00777 360911002206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911002208 putative substrate translocation pore; other site 360911002209 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 360911002210 Acylphosphatase; Region: Acylphosphatase; cl00551 360911002211 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911002212 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911002213 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 360911002214 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 360911002215 NAD binding site [chemical binding]; other site 360911002216 dimer interface [polypeptide binding]; other site 360911002217 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911002218 substrate binding site [chemical binding]; other site 360911002219 YCII-related domain; Region: YCII; cl00999 360911002220 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 360911002221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911002222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 360911002223 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 360911002224 FeS assembly protein SufB; Region: sufB; TIGR01980 360911002225 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 360911002226 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 360911002227 trimerization site [polypeptide binding]; other site 360911002228 active site 360911002229 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 360911002230 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 360911002231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911002232 catalytic residue [active] 360911002233 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 360911002234 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 360911002235 FeS assembly ATPase SufC; Region: sufC; TIGR01978 360911002236 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 360911002237 Walker A/P-loop; other site 360911002238 ATP binding site [chemical binding]; other site 360911002239 Q-loop/lid; other site 360911002240 ABC transporter signature motif; other site 360911002241 Walker B; other site 360911002242 D-loop; other site 360911002243 H-loop/switch region; other site 360911002244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002245 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911002246 putative substrate translocation pore; other site 360911002247 NMT1-like family; Region: NMT1_2; cl15260 360911002248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911002249 dimer interface [polypeptide binding]; other site 360911002250 conserved gate region; other site 360911002251 ABC-ATPase subunit interface; other site 360911002252 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 360911002253 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 360911002254 Walker A/P-loop; other site 360911002255 ATP binding site [chemical binding]; other site 360911002256 Q-loop/lid; other site 360911002257 ABC transporter signature motif; other site 360911002258 Walker B; other site 360911002259 D-loop; other site 360911002260 H-loop/switch region; other site 360911002261 NIL domain; Region: NIL; cl09633 360911002262 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911002263 catalytic residues [active] 360911002264 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911002265 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 360911002266 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 360911002267 lipoyl attachment site [posttranslational modification]; other site 360911002268 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 360911002269 ArsC family; Region: ArsC; pfam03960 360911002270 putative ArsC-like catalytic residues; other site 360911002271 putative TRX-like catalytic residues [active] 360911002272 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 360911002273 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 360911002274 active site 360911002275 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 360911002276 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 360911002277 dimer interface [polypeptide binding]; other site 360911002278 active site 360911002279 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 360911002280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002281 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 360911002282 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 360911002283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360911002284 substrate binding site [chemical binding]; other site 360911002285 oxyanion hole (OAH) forming residues; other site 360911002286 short chain dehydrogenase; Provisional; Region: PRK06701 360911002287 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 360911002288 NAD binding site [chemical binding]; other site 360911002289 metal binding site [ion binding]; metal-binding site 360911002290 active site 360911002291 YcxB-like protein; Region: YcxB; pfam14317 360911002292 YcxB-like protein; Region: YcxB; pfam14317 360911002293 Proline dehydrogenase; Region: Pro_dh; cl03282 360911002294 Haemolysin-III related; Region: HlyIII; cl03831 360911002295 Carbon starvation protein CstA; Region: CstA; pfam02554 360911002296 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 360911002297 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 360911002298 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 360911002299 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 360911002300 active site 360911002301 metal binding site [ion binding]; metal-binding site 360911002302 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360911002303 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 360911002304 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 360911002305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911002306 nucleotide binding region [chemical binding]; other site 360911002307 ATP-binding site [chemical binding]; other site 360911002308 DNA polymerase IV; Reviewed; Region: PRK03103 360911002309 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 360911002310 active site 360911002311 DNA binding site [nucleotide binding] 360911002312 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 360911002313 YolD-like protein; Region: YolD; pfam08863 360911002314 Sulfate transporter family; Region: Sulfate_transp; cl15842 360911002315 putative transporter; Provisional; Region: PRK11660 360911002316 Sulfate transporter family; Region: Sulfate_transp; cl15842 360911002317 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 360911002318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002319 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 360911002320 Walker A/P-loop; other site 360911002321 ATP binding site [chemical binding]; other site 360911002322 Q-loop/lid; other site 360911002323 ABC transporter signature motif; other site 360911002324 Walker B; other site 360911002325 D-loop; other site 360911002326 H-loop/switch region; other site 360911002327 Helix-turn-helix domains; Region: HTH; cl00088 360911002328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002329 NAD(P) binding site [chemical binding]; other site 360911002330 active site 360911002331 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 360911002332 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 360911002333 putative active site [active] 360911002334 putative NTP binding site [chemical binding]; other site 360911002335 putative nucleic acid binding site [nucleotide binding]; other site 360911002336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911002337 salt bridge; other site 360911002338 non-specific DNA binding site [nucleotide binding]; other site 360911002339 sequence-specific DNA binding site [nucleotide binding]; other site 360911002340 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911002341 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911002342 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360911002343 active site 360911002344 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 360911002345 SmpB-tmRNA interface; other site 360911002346 ribonuclease R; Region: RNase_R; TIGR02063 360911002347 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911002348 RNB domain; Region: RNB; pfam00773 360911002349 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 360911002350 RNA binding site [nucleotide binding]; other site 360911002351 Esterase/lipase [General function prediction only]; Region: COG1647 360911002352 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911002353 Preprotein translocase SecG subunit; Region: SecG; cl09123 360911002354 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002355 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002356 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002357 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911002358 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911002359 putative glycosyl transferase; Provisional; Region: PRK10307 360911002360 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 360911002361 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 360911002362 active site 360911002363 tetramer interface; other site 360911002364 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 360911002365 active site 360911002366 ATP binding site [chemical binding]; other site 360911002367 enolase; Provisional; Region: eno; PRK00077 360911002368 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 360911002369 dimer interface [polypeptide binding]; other site 360911002370 metal binding site [ion binding]; metal-binding site 360911002371 substrate binding pocket [chemical binding]; other site 360911002372 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 360911002373 Sulfatase; Region: Sulfatase; cl10460 360911002374 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 360911002375 substrate binding site [chemical binding]; other site 360911002376 dimer interface [polypeptide binding]; other site 360911002377 catalytic triad [active] 360911002378 Phosphoglycerate kinase; Region: PGK; pfam00162 360911002379 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 360911002380 substrate binding site [chemical binding]; other site 360911002381 hinge regions; other site 360911002382 ADP binding site [chemical binding]; other site 360911002383 catalytic site [active] 360911002384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002385 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 360911002386 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 360911002387 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 360911002388 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 360911002389 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 360911002390 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 360911002391 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 360911002392 Clp protease; Region: CLP_protease; pfam00574 360911002393 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 360911002394 oligomer interface [polypeptide binding]; other site 360911002395 active site residues [active] 360911002396 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 360911002397 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 360911002398 DNA binding residues [nucleotide binding] 360911002399 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 360911002400 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911002401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 360911002402 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 360911002403 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 360911002404 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 360911002405 phosphate binding site [ion binding]; other site 360911002406 putative substrate binding pocket [chemical binding]; other site 360911002407 dimer interface [polypeptide binding]; other site 360911002408 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 360911002409 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 360911002410 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 360911002411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002413 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 360911002414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911002415 binding surface 360911002416 TPR motif; other site 360911002417 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 360911002418 putative trimer interface [polypeptide binding]; other site 360911002419 putative CoA binding site [chemical binding]; other site 360911002420 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 360911002421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002422 motif II; other site 360911002423 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 360911002424 HPr kinase/phosphorylase; Provisional; Region: PRK05428 360911002425 DRTGG domain; Region: DRTGG; cl12147 360911002426 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 360911002427 Hpr binding site; other site 360911002428 active site 360911002429 homohexamer subunit interaction site [polypeptide binding]; other site 360911002430 Uncharacterized conserved protein [Function unknown]; Region: COG3595 360911002431 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360911002432 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 360911002433 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 360911002434 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 360911002435 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 360911002436 excinuclease ABC subunit B; Provisional; Region: PRK05298 360911002437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911002438 ATP binding site [chemical binding]; other site 360911002439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911002440 nucleotide binding region [chemical binding]; other site 360911002441 ATP-binding site [chemical binding]; other site 360911002442 Ultra-violet resistance protein B; Region: UvrB; pfam12344 360911002443 UvrB/uvrC motif; Region: UVR; pfam02151 360911002444 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 360911002445 amphipathic channel; other site 360911002446 Asn-Pro-Ala signature motifs; other site 360911002447 glycerol kinase; Provisional; Region: glpK; PRK00047 360911002448 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 360911002449 N- and C-terminal domain interface [polypeptide binding]; other site 360911002450 active site 360911002451 MgATP binding site [chemical binding]; other site 360911002452 catalytic site [active] 360911002453 metal binding site [ion binding]; metal-binding site 360911002454 glycerol binding site [chemical binding]; other site 360911002455 homotetramer interface [polypeptide binding]; other site 360911002456 homodimer interface [polypeptide binding]; other site 360911002457 FBP binding site [chemical binding]; other site 360911002458 protein IIAGlc interface [polypeptide binding]; other site 360911002459 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911002460 protein binding site [polypeptide binding]; other site 360911002461 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 360911002462 C-terminal peptidase (prc); Region: prc; TIGR00225 360911002463 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 360911002464 protein binding site [polypeptide binding]; other site 360911002465 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 360911002466 Catalytic dyad [active] 360911002467 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 360911002468 Plant ATP synthase F0; Region: YMF19; cl07975 360911002469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 360911002470 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911002471 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 360911002472 FtsX-like permease family; Region: FtsX; cl15850 360911002473 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 360911002474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002475 Walker A/P-loop; other site 360911002476 ATP binding site [chemical binding]; other site 360911002477 Q-loop/lid; other site 360911002478 ABC transporter signature motif; other site 360911002479 Walker B; other site 360911002480 D-loop; other site 360911002481 H-loop/switch region; other site 360911002482 Cytochrome c; Region: Cytochrom_C; cl11414 360911002483 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002484 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002485 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002486 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911002487 peptide chain release factor 2; Validated; Region: prfB; PRK00578 360911002488 RF-1 domain; Region: RF-1; cl02875 360911002489 RF-1 domain; Region: RF-1; cl02875 360911002490 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 360911002491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002492 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 360911002493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911002494 nucleotide binding region [chemical binding]; other site 360911002495 ATP-binding site [chemical binding]; other site 360911002496 SEC-C motif; Region: SEC-C; pfam02810 360911002497 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 360911002498 30S subunit binding site; other site 360911002499 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 360911002500 DNA-binding site [nucleotide binding]; DNA binding site 360911002501 RNA-binding motif; other site 360911002502 ComK protein; Region: ComK; cl11560 360911002503 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 360911002504 Flagellar protein FliS; Region: FliS; cl00654 360911002505 flagellin; Provisional; Region: PRK12804 360911002506 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360911002507 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 360911002508 Protein of unknown function (DUF327); Region: DUF327; cl00753 360911002509 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 360911002510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 360911002511 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 360911002512 DinB superfamily; Region: DinB_2; pfam12867 360911002513 Protein of unknown function (DUF402); Region: DUF402; cl00979 360911002514 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002515 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002516 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 360911002517 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 360911002518 Flagellar protein FliT; Region: FliT; cl05125 360911002519 Flagellar protein FliS; Region: FliS; cl00654 360911002520 flagellar capping protein; Validated; Region: fliD; PRK07737 360911002521 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 360911002522 Protein of unknown function (DUF690); Region: DUF690; cl04939 360911002523 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 360911002524 FlaG protein; Region: FlaG; cl00591 360911002525 flagellin; Provisional; Region: PRK12804 360911002526 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360911002527 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 360911002528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911002529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911002530 dimer interface [polypeptide binding]; other site 360911002531 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 360911002532 putative CheW interface [polypeptide binding]; other site 360911002533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002534 Coenzyme A binding pocket [chemical binding]; other site 360911002535 Predicted acetyltransferase [General function prediction only]; Region: COG3393 360911002536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002537 Coenzyme A binding pocket [chemical binding]; other site 360911002538 EamA-like transporter family; Region: EamA; cl01037 360911002539 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 360911002540 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002541 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002542 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002543 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911002544 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002545 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002546 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002547 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911002548 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 360911002549 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 360911002550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002551 metal binding site [ion binding]; metal-binding site 360911002552 active site 360911002553 I-site; other site 360911002554 Global regulator protein family; Region: CsrA; cl00670 360911002555 FliW protein; Region: FliW; cl00740 360911002556 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 360911002557 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360911002558 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 360911002559 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 360911002560 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 360911002561 FlgN protein; Region: FlgN; cl09176 360911002562 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 360911002563 flagellar operon protein TIGR03826; Region: YvyF 360911002564 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 360911002565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911002566 active site 360911002567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911002568 ATP binding site [chemical binding]; other site 360911002569 putative Mg++ binding site [ion binding]; other site 360911002570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911002571 nucleotide binding region [chemical binding]; other site 360911002572 ATP-binding site [chemical binding]; other site 360911002573 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911002574 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911002575 Ca binding site [ion binding]; other site 360911002576 active site 360911002577 catalytic site [active] 360911002578 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 360911002579 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911002580 active site turn [active] 360911002581 phosphorylation site [posttranslational modification] 360911002582 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911002583 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 360911002584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911002585 DNA-binding site [nucleotide binding]; DNA binding site 360911002586 UTRA domain; Region: UTRA; cl01230 360911002587 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 360911002588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 360911002589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911002590 active site 360911002591 phosphorylation site [posttranslational modification] 360911002592 intermolecular recognition site; other site 360911002593 dimerization interface [polypeptide binding]; other site 360911002594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360911002595 DNA binding residues [nucleotide binding] 360911002596 dimerization interface [polypeptide binding]; other site 360911002597 Sensor protein DegS; Region: DegS; pfam05384 360911002598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 360911002599 Histidine kinase; Region: HisKA_3; pfam07730 360911002600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911002601 ATP binding site [chemical binding]; other site 360911002602 Mg2+ binding site [ion binding]; other site 360911002603 G-X-G motif; other site 360911002604 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 360911002605 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 360911002606 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 360911002607 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 360911002608 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 360911002609 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 360911002610 Mg++ binding site [ion binding]; other site 360911002611 putative catalytic motif [active] 360911002612 substrate binding site [chemical binding]; other site 360911002613 beta-phosphoglucomutase; Region: bPGM; TIGR01990 360911002614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002615 motif II; other site 360911002616 Asp23 family; Region: Asp23; cl00574 360911002617 OpgC protein; Region: OpgC_C; cl00792 360911002618 Predicted esterase [General function prediction only]; Region: COG0400 360911002619 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 360911002620 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 360911002621 Walker A/P-loop; other site 360911002622 ATP binding site [chemical binding]; other site 360911002623 Q-loop/lid; other site 360911002624 ABC transporter signature motif; other site 360911002625 Walker B; other site 360911002626 D-loop; other site 360911002627 H-loop/switch region; other site 360911002628 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 360911002629 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 360911002630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911002631 non-specific DNA binding site [nucleotide binding]; other site 360911002632 salt bridge; other site 360911002633 sequence-specific DNA binding site [nucleotide binding]; other site 360911002634 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911002635 HPr interaction site; other site 360911002636 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911002637 active site 360911002638 phosphorylation site [posttranslational modification] 360911002639 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 360911002640 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 360911002641 active site 360911002642 Zn binding site [ion binding]; other site 360911002643 Domain of unknown function (DUF389); Region: DUF389; cl00781 360911002644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911002645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911002646 active site 360911002647 catalytic tetrad [active] 360911002648 Cupin domain; Region: Cupin_2; cl09118 360911002649 Helix-turn-helix domains; Region: HTH; cl00088 360911002650 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 360911002651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002652 putative substrate translocation pore; other site 360911002653 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 360911002654 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 360911002655 FOG: CBS domain [General function prediction only]; Region: COG0517 360911002656 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 360911002657 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911002658 Secretory lipase; Region: LIP; pfam03583 360911002659 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 360911002660 active site 360911002661 Zn binding site [ion binding]; other site 360911002662 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911002663 Protein of unknown function (DUF541); Region: SIMPL; cl01077 360911002664 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 360911002665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911002666 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 360911002667 Helix-turn-helix domains; Region: HTH; cl00088 360911002668 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 360911002669 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 360911002670 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 360911002671 FMN binding site [chemical binding]; other site 360911002672 active site 360911002673 catalytic residues [active] 360911002674 substrate binding site [chemical binding]; other site 360911002675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911002676 Helix-turn-helix domains; Region: HTH; cl00088 360911002677 AAA domain; Region: AAA_33; pfam13671 360911002678 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 360911002679 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911002680 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 360911002681 Protein of unknown function DUF262; Region: DUF262; cl14890 360911002682 Protein of unknown function DUF262; Region: DUF262; cl14890 360911002683 Protein of unknown function DUF262; Region: DUF262; cl14890 360911002684 TRAM domain; Region: TRAM; cl01282 360911002685 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 360911002686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911002687 S-adenosylmethionine binding site [chemical binding]; other site 360911002688 putative lipid kinase; Reviewed; Region: PRK13337 360911002689 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 360911002690 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 360911002691 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 360911002692 GatB domain; Region: GatB_Yqey; cl11497 360911002693 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 360911002694 Amidase; Region: Amidase; cl11426 360911002695 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 360911002696 CHASE3 domain; Region: CHASE3; cl05000 360911002697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911002698 dimerization interface [polypeptide binding]; other site 360911002699 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911002700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911002701 dimer interface [polypeptide binding]; other site 360911002702 putative CheW interface [polypeptide binding]; other site 360911002703 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911002704 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911002705 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 360911002706 catalytic triad [active] 360911002707 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 360911002708 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 360911002709 Glutamate binding site [chemical binding]; other site 360911002710 homodimer interface [polypeptide binding]; other site 360911002711 NAD binding site [chemical binding]; other site 360911002712 catalytic residues [active] 360911002713 GAF domain; Region: GAF; cl15785 360911002714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911002715 Zn2+ binding site [ion binding]; other site 360911002716 Mg2+ binding site [ion binding]; other site 360911002717 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 360911002718 homopentamer interface [polypeptide binding]; other site 360911002719 active site 360911002720 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 360911002721 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 360911002722 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 360911002723 dimerization interface [polypeptide binding]; other site 360911002724 active site 360911002725 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 360911002726 Lumazine binding domain; Region: Lum_binding; pfam00677 360911002727 Lumazine binding domain; Region: Lum_binding; pfam00677 360911002728 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 360911002729 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 360911002730 catalytic motif [active] 360911002731 Zn binding site [ion binding]; other site 360911002732 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 360911002733 Bacitracin resistance protein BacA; Region: BacA; cl00858 360911002734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002735 metal binding site [ion binding]; metal-binding site 360911002736 active site 360911002737 I-site; other site 360911002738 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 360911002739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911002740 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 360911002741 Walker A/P-loop; other site 360911002742 ATP binding site [chemical binding]; other site 360911002743 Q-loop/lid; other site 360911002744 ABC transporter signature motif; other site 360911002745 Walker B; other site 360911002746 D-loop; other site 360911002747 H-loop/switch region; other site 360911002748 FtsX-like permease family; Region: FtsX; cl15850 360911002749 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 360911002750 FtsX-like permease family; Region: FtsX; cl15850 360911002751 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 360911002752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002753 Coenzyme A binding pocket [chemical binding]; other site 360911002754 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 360911002755 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911002756 catalytic residues [active] 360911002757 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 360911002758 RDD family; Region: RDD; cl00746 360911002759 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 360911002760 active site 360911002761 dimer interface [polypeptide binding]; other site 360911002762 PAS fold; Region: PAS_4; pfam08448 360911002763 PAS fold; Region: PAS_3; pfam08447 360911002764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002765 metal binding site [ion binding]; metal-binding site 360911002766 active site 360911002767 I-site; other site 360911002768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911002769 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 360911002770 carbohydrate binding site [chemical binding]; other site 360911002771 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 360911002772 carbohydrate binding site [chemical binding]; other site 360911002773 pullulanase, type I; Region: pulA_typeI; TIGR02104 360911002774 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 360911002775 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 360911002776 Ca binding site [ion binding]; other site 360911002777 active site 360911002778 catalytic site [active] 360911002779 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 360911002780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002781 metal binding site [ion binding]; metal-binding site 360911002782 active site 360911002783 I-site; other site 360911002784 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 360911002785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002786 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911002787 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 360911002788 active site residue [active] 360911002789 arsenical pump membrane protein; Provisional; Region: PRK15445 360911002790 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 360911002791 transmembrane helices; other site 360911002792 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 360911002793 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 360911002794 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 360911002795 P loop; other site 360911002796 Nucleotide binding site [chemical binding]; other site 360911002797 DTAP/Switch II; other site 360911002798 Switch I; other site 360911002799 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 360911002800 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 360911002801 DTAP/Switch II; other site 360911002802 Switch I; other site 360911002803 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 360911002804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911002805 dimerization interface [polypeptide binding]; other site 360911002806 putative DNA binding site [nucleotide binding]; other site 360911002807 putative Zn2+ binding site [ion binding]; other site 360911002808 Sulfate transporter family; Region: Sulfate_transp; cl15842 360911002809 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 360911002810 Sulfate transporter family; Region: Sulfate_transp; cl15842 360911002811 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 360911002812 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 360911002813 Ligand Binding Site [chemical binding]; other site 360911002814 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911002815 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911002816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002817 Walker A/P-loop; other site 360911002818 ATP binding site [chemical binding]; other site 360911002819 Q-loop/lid; other site 360911002820 ABC transporter signature motif; other site 360911002821 Walker B; other site 360911002822 D-loop; other site 360911002823 H-loop/switch region; other site 360911002824 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911002825 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 360911002826 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 360911002827 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 360911002828 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 360911002829 putative active site [active] 360911002830 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 360911002831 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002832 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 360911002833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911002834 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002835 Walker A/P-loop; other site 360911002836 ATP binding site [chemical binding]; other site 360911002837 Q-loop/lid; other site 360911002838 ABC transporter signature motif; other site 360911002839 Walker B; other site 360911002840 D-loop; other site 360911002841 H-loop/switch region; other site 360911002842 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 360911002843 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 360911002844 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911002845 PAS domain; Region: PAS_9; pfam13426 360911002846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911002847 PAS domain; Region: PAS_9; pfam13426 360911002848 putative active site [active] 360911002849 heme pocket [chemical binding]; other site 360911002850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911002851 PAS fold; Region: PAS_3; pfam08447 360911002852 putative active site [active] 360911002853 heme pocket [chemical binding]; other site 360911002854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002855 metal binding site [ion binding]; metal-binding site 360911002856 active site 360911002857 I-site; other site 360911002858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911002859 Zn2+ binding site [ion binding]; other site 360911002860 Mg2+ binding site [ion binding]; other site 360911002861 Helix-turn-helix domains; Region: HTH; cl00088 360911002862 Chromate transporter; Region: Chromate_transp; pfam02417 360911002863 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 360911002864 Chromate transporter; Region: Chromate_transp; pfam02417 360911002865 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 360911002866 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 360911002867 putative substrate binding site [chemical binding]; other site 360911002868 putative ATP binding site [chemical binding]; other site 360911002869 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 360911002870 hypothetical protein; Provisional; Region: PRK08185 360911002871 intersubunit interface [polypeptide binding]; other site 360911002872 active site 360911002873 zinc binding site [ion binding]; other site 360911002874 Na+ binding site [ion binding]; other site 360911002875 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 360911002876 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 360911002877 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360911002878 Helix-turn-helix domains; Region: HTH; cl00088 360911002879 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 360911002880 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911002881 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911002882 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911002883 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 360911002884 active site 360911002885 P-loop; other site 360911002886 phosphorylation site [posttranslational modification] 360911002887 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 360911002888 active site 360911002889 methionine cluster; other site 360911002890 phosphorylation site [posttranslational modification] 360911002891 metal binding site [ion binding]; metal-binding site 360911002892 OpgC protein; Region: OpgC_C; cl00792 360911002893 Acyltransferase family; Region: Acyl_transf_3; pfam01757 360911002894 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 360911002895 catalytic triad [active] 360911002896 catalytic triad [active] 360911002897 oxyanion hole [active] 360911002898 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 360911002899 putative active site [active] 360911002900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911002901 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911002902 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 360911002903 DHHW protein; Region: DHHW; pfam14286 360911002904 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 360911002905 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 360911002906 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 360911002907 active site 360911002908 homodimer interface [polypeptide binding]; other site 360911002909 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 360911002910 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 360911002911 Walker A/P-loop; other site 360911002912 ATP binding site [chemical binding]; other site 360911002913 Q-loop/lid; other site 360911002914 ABC transporter signature motif; other site 360911002915 Walker B; other site 360911002916 D-loop; other site 360911002917 H-loop/switch region; other site 360911002918 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911002919 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 360911002920 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360911002921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002922 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911002923 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911002924 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911002925 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911002926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 360911002927 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911002928 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911002929 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911002930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 360911002931 active site 360911002932 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 360911002933 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 360911002934 active site 360911002935 metal binding site [ion binding]; metal-binding site 360911002936 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360911002937 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 360911002938 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 360911002939 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002940 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002941 Bacterial SH3 domain; Region: SH3_3; cl02551 360911002942 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 360911002943 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 360911002944 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911002945 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 360911002946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911002947 active site 360911002948 DNA binding site [nucleotide binding] 360911002949 Int/Topo IB signature motif; other site 360911002950 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 360911002951 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 360911002952 Collagen binding domain; Region: Collagen_bind; pfam05737 360911002953 Collagen binding domain; Region: Collagen_bind; pfam05737 360911002954 Collagen binding domain; Region: Collagen_bind; pfam05737 360911002955 Collagen binding domain; Region: Collagen_bind; pfam05737 360911002956 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002957 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002958 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002959 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002960 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002961 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002962 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002963 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002964 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911002965 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 360911002966 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 360911002967 Domain of unknown function DUF87; Region: DUF87; pfam01935 360911002968 AAA-like domain; Region: AAA_10; pfam12846 360911002969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002970 Dynamin family; Region: Dynamin_N; pfam00350 360911002971 G1 box; other site 360911002972 GTP/Mg2+ binding site [chemical binding]; other site 360911002973 G2 box; other site 360911002974 Switch I region; other site 360911002975 G3 box; other site 360911002976 Switch II region; other site 360911002977 G4 box; other site 360911002978 G5 box; other site 360911002979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002980 Dynamin family; Region: Dynamin_N; pfam00350 360911002981 G1 box; other site 360911002982 GTP/Mg2+ binding site [chemical binding]; other site 360911002983 G2 box; other site 360911002984 Switch I region; other site 360911002985 G3 box; other site 360911002986 Switch II region; other site 360911002987 G4 box; other site 360911002988 G5 box; other site 360911002989 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 360911002990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911002991 DNA helicase IV; Provisional; Region: helD; PRK11054 360911002992 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911002993 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911002994 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 360911002995 coenzyme A binding site [chemical binding]; other site 360911002996 citrylCoA binding site [chemical binding]; other site 360911002997 catalytic triad [active] 360911002998 Bacterial Ig-like domain; Region: Big_5; cl01012 360911002999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 360911003000 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 360911003001 Probable transposase; Region: OrfB_IS605; pfam01385 360911003002 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 360911003003 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 360911003004 active site 360911003005 catalytic triad [active] 360911003006 NlpC/P60 family; Region: NLPC_P60; cl11438 360911003007 anthranilate synthase component I; Provisional; Region: PRK13570 360911003008 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 360911003009 chorismate binding enzyme; Region: Chorismate_bind; cl10555 360911003010 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 360911003011 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 360911003012 glutamine binding [chemical binding]; other site 360911003013 catalytic triad [active] 360911003014 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 360911003015 FAD binding pocket [chemical binding]; other site 360911003016 conserved FAD binding motif [chemical binding]; other site 360911003017 phosphate binding motif [ion binding]; other site 360911003018 beta-alpha-beta structure motif; other site 360911003019 NAD binding pocket [chemical binding]; other site 360911003020 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 360911003021 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360911003022 Walker A/P-loop; other site 360911003023 ATP binding site [chemical binding]; other site 360911003024 Q-loop/lid; other site 360911003025 ABC transporter signature motif; other site 360911003026 Walker B; other site 360911003027 D-loop; other site 360911003028 H-loop/switch region; other site 360911003029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003030 ABC-ATPase subunit interface; other site 360911003031 dimer interface [polypeptide binding]; other site 360911003032 putative PBP binding regions; other site 360911003033 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003034 ABC-ATPase subunit interface; other site 360911003035 dimer interface [polypeptide binding]; other site 360911003036 putative PBP binding regions; other site 360911003037 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 360911003038 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 360911003039 intersubunit interface [polypeptide binding]; other site 360911003040 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 360911003041 Helix-turn-helix domains; Region: HTH; cl00088 360911003042 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 360911003043 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 360911003044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 360911003045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 360911003047 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 360911003048 Probable transposase; Region: OrfB_IS605; pfam01385 360911003049 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 360911003050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003052 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 360911003053 dimer interface [polypeptide binding]; other site 360911003054 putative metal binding site [ion binding]; other site 360911003055 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 360911003056 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 360911003057 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 360911003058 Walker A/P-loop; other site 360911003059 ATP binding site [chemical binding]; other site 360911003060 Q-loop/lid; other site 360911003061 ABC transporter signature motif; other site 360911003062 Walker B; other site 360911003063 D-loop; other site 360911003064 H-loop/switch region; other site 360911003065 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911003066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911003067 DNA-binding site [nucleotide binding]; DNA binding site 360911003068 UTRA domain; Region: UTRA; cl01230 360911003069 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 360911003070 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 360911003071 NAD binding site [chemical binding]; other site 360911003072 sugar binding site [chemical binding]; other site 360911003073 divalent metal binding site [ion binding]; other site 360911003074 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911003075 dimer interface [polypeptide binding]; other site 360911003076 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911003077 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911003078 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 360911003079 methionine cluster; other site 360911003080 active site 360911003081 phosphorylation site [posttranslational modification] 360911003082 metal binding site [ion binding]; metal-binding site 360911003083 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 360911003084 active site 360911003085 P-loop; other site 360911003086 phosphorylation site [posttranslational modification] 360911003087 YdjC-like protein; Region: YdjC; cl01344 360911003088 AAA domain; Region: AAA_18; pfam13238 360911003089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911003090 Cation efflux family; Region: Cation_efflux; cl00316 360911003091 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911003092 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911003093 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911003094 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 360911003095 peptidase T-like protein; Region: PepT-like; TIGR01883 360911003096 metal binding site [ion binding]; metal-binding site 360911003097 putative dimer interface [polypeptide binding]; other site 360911003098 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 360911003099 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360911003100 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 360911003101 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 360911003102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 360911003103 TPR motif; other site 360911003104 binding surface 360911003105 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077 360911003106 classical (c) SDRs; Region: SDR_c; cd05233 360911003107 NAD(P) binding site [chemical binding]; other site 360911003108 active site 360911003109 CHASE3 domain; Region: CHASE3; cl05000 360911003110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003111 dimerization interface [polypeptide binding]; other site 360911003112 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911003113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003114 dimer interface [polypeptide binding]; other site 360911003115 putative CheW interface [polypeptide binding]; other site 360911003116 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 360911003117 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911003118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003119 dimerization interface [polypeptide binding]; other site 360911003120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003121 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003122 dimer interface [polypeptide binding]; other site 360911003123 putative CheW interface [polypeptide binding]; other site 360911003124 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 360911003125 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 360911003126 YvrJ protein family; Region: YvrJ; pfam12841 360911003127 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 360911003128 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 360911003129 FtsX-like permease family; Region: FtsX; cl15850 360911003130 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911003131 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 360911003132 Walker A/P-loop; other site 360911003133 ATP binding site [chemical binding]; other site 360911003134 Q-loop/lid; other site 360911003135 ABC transporter signature motif; other site 360911003136 Walker B; other site 360911003137 D-loop; other site 360911003138 H-loop/switch region; other site 360911003139 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911003140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003141 active site 360911003142 phosphorylation site [posttranslational modification] 360911003143 intermolecular recognition site; other site 360911003144 dimerization interface [polypeptide binding]; other site 360911003145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911003146 DNA binding site [nucleotide binding] 360911003147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003148 dimer interface [polypeptide binding]; other site 360911003149 phosphorylation site [posttranslational modification] 360911003150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003151 ATP binding site [chemical binding]; other site 360911003152 Mg2+ binding site [ion binding]; other site 360911003153 G-X-G motif; other site 360911003154 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 360911003155 GAF domain; Region: GAF; cl15785 360911003156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003157 metal binding site [ion binding]; metal-binding site 360911003158 active site 360911003159 I-site; other site 360911003160 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003161 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911003162 putative peptidoglycan binding site; other site 360911003163 Bacterial SH3 domain; Region: SH3_3; cl02551 360911003164 Bacterial SH3 domain; Region: SH3_3; cl02551 360911003165 Bacterial SH3 domain; Region: SH3_3; cl02551 360911003166 Bacterial SH3 domain; Region: SH3_3; cl02551 360911003167 NlpC/P60 family; Region: NLPC_P60; cl11438 360911003168 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 360911003169 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003170 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 360911003171 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 360911003172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003173 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360911003174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003175 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 360911003176 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 360911003177 WxL domain surface cell wall-binding; Region: WxL; pfam13731 360911003178 Vta1 like; Region: DUF605; pfam04652 360911003179 WxL domain surface cell wall-binding; Region: WxL; pfam13731 360911003180 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003181 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 360911003182 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 360911003183 active site 360911003184 WbqC-like protein family; Region: WbqC; pfam08889 360911003185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911003186 active site 360911003187 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 360911003188 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 360911003189 NAD binding site [chemical binding]; other site 360911003190 substrate binding site [chemical binding]; other site 360911003191 homodimer interface [polypeptide binding]; other site 360911003192 active site 360911003193 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 360911003194 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 360911003195 substrate binding site; other site 360911003196 tetramer interface; other site 360911003197 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 360911003198 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 360911003199 inhibitor-cofactor binding pocket; inhibition site 360911003200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911003201 catalytic residue [active] 360911003202 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911003203 active site 360911003204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003205 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 360911003206 NAD(P) binding site [chemical binding]; other site 360911003207 active site 360911003208 Cupin domain; Region: Cupin_2; cl09118 360911003209 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911003210 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911003211 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911003212 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 360911003213 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 360911003214 NAD(P) binding site [chemical binding]; other site 360911003215 homodimer interface [polypeptide binding]; other site 360911003216 substrate binding site [chemical binding]; other site 360911003217 active site 360911003218 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 360911003219 Bacterial sugar transferase; Region: Bac_transf; cl00939 360911003220 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 360911003221 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 360911003222 active site 360911003223 homodimer interface [polypeptide binding]; other site 360911003224 MatE; Region: MatE; cl10513 360911003225 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 360911003226 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911003227 active site 360911003228 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911003229 putative glycosyl transferase; Provisional; Region: PRK10125 360911003230 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 360911003231 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911003232 active site turn [active] 360911003233 phosphorylation site [posttranslational modification] 360911003234 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911003235 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911003236 HPr interaction site; other site 360911003237 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911003238 active site 360911003239 phosphorylation site [posttranslational modification] 360911003240 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911003241 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 360911003242 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 360911003243 active site 360911003244 catalytic residues [active] 360911003245 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 360911003246 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 360911003247 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 360911003248 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 360911003249 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 360911003250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003251 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911003252 UDP-glucose 4-epimerase; Region: PLN02240 360911003253 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 360911003254 NAD binding site [chemical binding]; other site 360911003255 homodimer interface [polypeptide binding]; other site 360911003256 active site 360911003257 substrate binding site [chemical binding]; other site 360911003258 Predicted membrane protein [Function unknown]; Region: COG4267 360911003259 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 360911003260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 360911003261 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 360911003262 NodB motif; other site 360911003263 putative active site [active] 360911003264 putative catalytic site [active] 360911003265 putative Zn binding site [ion binding]; other site 360911003266 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 360911003267 GAF domain; Region: GAF; cl15785 360911003268 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 360911003269 TM1410 hypothetical-related protein; Region: DUF297; cl00997 360911003270 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 360911003271 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 360911003272 active site 360911003273 FMN binding site [chemical binding]; other site 360911003274 substrate binding site [chemical binding]; other site 360911003275 3Fe-4S cluster binding site [ion binding]; other site 360911003276 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360911003277 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360911003278 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360911003279 putative active site [active] 360911003280 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 360911003281 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911003282 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911003283 PAS domain; Region: PAS_9; pfam13426 360911003284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911003285 putative active site [active] 360911003286 heme pocket [chemical binding]; other site 360911003287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003288 metal binding site [ion binding]; metal-binding site 360911003289 active site 360911003290 I-site; other site 360911003291 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911003293 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911003294 putative substrate translocation pore; other site 360911003295 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 360911003296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003297 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 360911003298 GntP family permease; Region: GntP_permease; pfam02447 360911003299 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 360911003300 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 360911003301 N- and C-terminal domain interface [polypeptide binding]; other site 360911003302 putative active site [active] 360911003303 catalytic site [active] 360911003304 metal binding site [ion binding]; metal-binding site 360911003305 carbohydrate binding site [chemical binding]; other site 360911003306 ATP binding site [chemical binding]; other site 360911003307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911003308 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003309 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 360911003310 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 360911003311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003312 metal binding site [ion binding]; metal-binding site 360911003313 active site 360911003314 I-site; other site 360911003315 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 360911003316 folate binding site [chemical binding]; other site 360911003317 NADP+ binding site [chemical binding]; other site 360911003318 Predicted transcriptional regulator [Transcription]; Region: COG2378 360911003319 Helix-turn-helix domains; Region: HTH; cl00088 360911003320 WYL domain; Region: WYL; cl14852 360911003321 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911003322 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 360911003323 active site 360911003324 catalytic motif [active] 360911003325 Zn binding site [ion binding]; other site 360911003326 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 360911003327 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360911003328 Walker A/P-loop; other site 360911003329 ATP binding site [chemical binding]; other site 360911003330 Q-loop/lid; other site 360911003331 ABC transporter signature motif; other site 360911003332 Walker B; other site 360911003333 D-loop; other site 360911003334 H-loop/switch region; other site 360911003335 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 360911003336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003337 ABC-ATPase subunit interface; other site 360911003338 dimer interface [polypeptide binding]; other site 360911003339 putative PBP binding regions; other site 360911003340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003341 ABC-ATPase subunit interface; other site 360911003342 dimer interface [polypeptide binding]; other site 360911003343 putative PBP binding regions; other site 360911003344 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 360911003345 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 360911003346 siderophore binding site; other site 360911003347 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 360911003348 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 360911003349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911003350 motif II; other site 360911003351 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911003352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911003353 Coenzyme A binding pocket [chemical binding]; other site 360911003354 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911003355 Helix-turn-helix domains; Region: HTH; cl00088 360911003356 Helix-turn-helix domains; Region: HTH; cl00088 360911003357 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 360911003358 Protein of unknown function (DUF419); Region: DUF419; cl15265 360911003359 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 360911003360 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 360911003361 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003362 dimerization interface [polypeptide binding]; other site 360911003363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003364 dimer interface [polypeptide binding]; other site 360911003365 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911003366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003367 dimer interface [polypeptide binding]; other site 360911003368 putative CheW interface [polypeptide binding]; other site 360911003369 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911003370 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 360911003371 NodB motif; other site 360911003372 active site 360911003373 catalytic site [active] 360911003374 Zn binding site [ion binding]; other site 360911003375 cytochrome b; Provisional; Region: CYTB; MTH00074 360911003376 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911003377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003378 dimer interface [polypeptide binding]; other site 360911003379 putative CheW interface [polypeptide binding]; other site 360911003380 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 360911003381 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 360911003382 NADP binding site [chemical binding]; other site 360911003383 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 360911003384 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 360911003385 Ligand Binding Site [chemical binding]; other site 360911003386 K+-transporting ATPase, c chain; Region: KdpC; cl00944 360911003387 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 360911003388 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911003389 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911003390 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 360911003391 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 360911003392 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911003393 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911003394 Integral membrane protein TerC family; Region: TerC; cl10468 360911003395 Bacterial SH3 domain; Region: SH3_3; cl02551 360911003396 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911003397 Domain of unknown function (DUF305); Region: DUF305; cl15795 360911003398 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911003399 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911003400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003401 active site 360911003402 phosphorylation site [posttranslational modification] 360911003403 intermolecular recognition site; other site 360911003404 dimerization interface [polypeptide binding]; other site 360911003405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911003406 DNA binding site [nucleotide binding] 360911003407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911003408 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911003409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003410 dimer interface [polypeptide binding]; other site 360911003411 phosphorylation site [posttranslational modification] 360911003412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003413 ATP binding site [chemical binding]; other site 360911003414 Mg2+ binding site [ion binding]; other site 360911003415 G-X-G motif; other site 360911003416 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 360911003417 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911003418 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911003419 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 360911003420 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 360911003421 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 360911003422 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 360911003423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 360911003424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003425 dimer interface [polypeptide binding]; other site 360911003426 phosphorylation site [posttranslational modification] 360911003427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003428 ATP binding site [chemical binding]; other site 360911003429 Mg2+ binding site [ion binding]; other site 360911003430 G-X-G motif; other site 360911003431 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911003432 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911003433 Ca binding site [ion binding]; other site 360911003434 active site 360911003435 catalytic site [active] 360911003436 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 360911003437 beta-phosphoglucomutase; Region: bPGM; TIGR01990 360911003438 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911003439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911003440 motif II; other site 360911003441 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911003442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911003443 dimer interface [polypeptide binding]; other site 360911003444 conserved gate region; other site 360911003445 putative PBP binding loops; other site 360911003446 ABC-ATPase subunit interface; other site 360911003447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911003448 dimer interface [polypeptide binding]; other site 360911003449 conserved gate region; other site 360911003450 putative PBP binding loops; other site 360911003451 ABC-ATPase subunit interface; other site 360911003452 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 360911003453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911003454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911003455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911003456 DNA binding site [nucleotide binding] 360911003457 domain linker motif; other site 360911003458 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 360911003459 dimerization interface [polypeptide binding]; other site 360911003460 ligand binding site [chemical binding]; other site 360911003461 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 360911003462 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 360911003463 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 360911003464 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 360911003465 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 360911003466 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 360911003467 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 360911003468 substrate binding [chemical binding]; other site 360911003469 active site 360911003470 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 360911003471 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 360911003472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003473 metal binding site [ion binding]; metal-binding site 360911003474 active site 360911003475 I-site; other site 360911003476 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 360911003477 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 360911003478 active site 360911003479 catalytic site [active] 360911003480 metal binding site [ion binding]; metal-binding site 360911003481 dimer interface [polypeptide binding]; other site 360911003482 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360911003483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911003484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911003485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911003486 dimer interface [polypeptide binding]; other site 360911003487 conserved gate region; other site 360911003488 putative PBP binding loops; other site 360911003489 ABC-ATPase subunit interface; other site 360911003490 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 360911003491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 360911003492 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360911003493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911003494 Walker A/P-loop; other site 360911003495 ATP binding site [chemical binding]; other site 360911003496 Q-loop/lid; other site 360911003497 ABC transporter signature motif; other site 360911003498 Walker B; other site 360911003499 D-loop; other site 360911003500 H-loop/switch region; other site 360911003501 TOBE domain; Region: TOBE_2; cl01440 360911003502 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 360911003503 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 360911003504 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 360911003505 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 360911003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911003507 S-adenosylmethionine binding site [chemical binding]; other site 360911003508 GAF domain; Region: GAF_2; pfam13185 360911003509 GAF domain; Region: GAF; cl15785 360911003510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003511 metal binding site [ion binding]; metal-binding site 360911003512 active site 360911003513 I-site; other site 360911003514 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 360911003515 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 360911003516 putative active site cavity [active] 360911003517 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360911003518 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360911003519 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360911003520 putative active site [active] 360911003521 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 360911003522 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911003523 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911003524 active site turn [active] 360911003525 phosphorylation site [posttranslational modification] 360911003526 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 360911003527 active site 360911003528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003529 dimerization interface [polypeptide binding]; other site 360911003530 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911003531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003532 dimer interface [polypeptide binding]; other site 360911003533 putative CheW interface [polypeptide binding]; other site 360911003534 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 360911003535 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 360911003536 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 360911003537 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 360911003538 Glycerate kinase family; Region: Gly_kinase; cl00841 360911003539 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 360911003540 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 360911003541 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 360911003542 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 360911003543 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 360911003544 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 360911003545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911003546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 360911003547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003548 dimer interface [polypeptide binding]; other site 360911003549 phosphorylation site [posttranslational modification] 360911003550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003551 ATP binding site [chemical binding]; other site 360911003552 Mg2+ binding site [ion binding]; other site 360911003553 G-X-G motif; other site 360911003554 Histidine kinase; Region: His_kinase; pfam06580 360911003555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003556 ATP binding site [chemical binding]; other site 360911003557 Mg2+ binding site [ion binding]; other site 360911003558 G-X-G motif; other site 360911003559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003560 Response regulator receiver domain; Region: Response_reg; pfam00072 360911003561 active site 360911003562 phosphorylation site [posttranslational modification] 360911003563 intermolecular recognition site; other site 360911003564 dimerization interface [polypeptide binding]; other site 360911003565 Helix-turn-helix domains; Region: HTH; cl00088 360911003566 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 360911003567 classical (c) SDRs; Region: SDR_c; cd05233 360911003568 NAD(P) binding site [chemical binding]; other site 360911003569 active site 360911003570 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003571 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911003572 active site 360911003573 metal binding site [ion binding]; metal-binding site 360911003574 rod shape-determining protein Mbl; Provisional; Region: PRK13928 360911003575 Cell division protein FtsA; Region: FtsA; cl11496 360911003576 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 360911003577 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 360911003578 hinge; other site 360911003579 active site 360911003580 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 360911003581 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003582 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 360911003583 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 360911003584 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 360911003585 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 360911003586 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 360911003587 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 360911003588 alpha subunit interaction interface [polypeptide binding]; other site 360911003589 Walker A motif; other site 360911003590 ATP binding site [chemical binding]; other site 360911003591 Walker B motif; other site 360911003592 inhibitor binding site; inhibition site 360911003593 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 360911003594 ATP synthase; Region: ATP-synt; cl00365 360911003595 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 360911003596 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 360911003597 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 360911003598 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 360911003599 beta subunit interaction interface [polypeptide binding]; other site 360911003600 Walker A motif; other site 360911003601 ATP binding site [chemical binding]; other site 360911003602 Walker B motif; other site 360911003603 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 360911003604 Plant ATP synthase F0; Region: YMF19; cl07975 360911003605 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 360911003606 Plant ATP synthase F0; Region: YMF19; cl07975 360911003607 ATP synthase subunit C; Region: ATP-synt_C; cl00466 360911003608 ATP synthase A chain; Region: ATP-synt_A; cl00413 360911003609 ATP synthase I chain; Region: ATP_synt_I; cl09170 360911003610 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911003611 active site 360911003612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911003613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911003614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003615 dimer interface [polypeptide binding]; other site 360911003616 phosphorylation site [posttranslational modification] 360911003617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003618 ATP binding site [chemical binding]; other site 360911003619 Mg2+ binding site [ion binding]; other site 360911003620 G-X-G motif; other site 360911003621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911003622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003623 active site 360911003624 phosphorylation site [posttranslational modification] 360911003625 intermolecular recognition site; other site 360911003626 dimerization interface [polypeptide binding]; other site 360911003627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911003628 DNA binding site [nucleotide binding] 360911003629 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 360911003630 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 360911003631 dimer interface [polypeptide binding]; other site 360911003632 active site 360911003633 glycine-pyridoxal phosphate binding site [chemical binding]; other site 360911003634 folate binding site [chemical binding]; other site 360911003635 Putative esterase; Region: Esterase; pfam00756 360911003636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911003637 Helix-turn-helix domains; Region: HTH; cl00088 360911003638 Helix-turn-helix domains; Region: HTH; cl00088 360911003639 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 360911003640 classical (c) SDRs; Region: SDR_c; cd05233 360911003641 NAD(P) binding site [chemical binding]; other site 360911003642 active site 360911003643 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911003644 Helix-turn-helix domains; Region: HTH; cl00088 360911003645 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 360911003646 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 360911003647 potential catalytic triad [active] 360911003648 conserved cys residue [active] 360911003649 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 360911003650 Protein of unknown function (DUF436); Region: DUF436; cl01860 360911003651 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 360911003652 Low molecular weight phosphatase family; Region: LMWPc; cd00115 360911003653 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 360911003654 active site 360911003655 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 360911003656 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 360911003657 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 360911003658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911003659 S-adenosylmethionine binding site [chemical binding]; other site 360911003660 peptide chain release factor 1; Validated; Region: prfA; PRK00591 360911003661 RF-1 domain; Region: RF-1; cl02875 360911003662 RF-1 domain; Region: RF-1; cl02875 360911003663 thymidine kinase; Provisional; Region: PRK04296 360911003664 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 360911003665 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 360911003666 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 360911003667 transcription termination factor Rho; Provisional; Region: rho; PRK09376 360911003668 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 360911003669 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 360911003670 RNA binding site [nucleotide binding]; other site 360911003671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911003672 Walker A motif; other site 360911003673 ATP binding site [chemical binding]; other site 360911003674 Walker B motif; other site 360911003675 Bacterial SH3 domain; Region: SH3_3; cl02551 360911003676 NlpC/P60 family; Region: NLPC_P60; cl11438 360911003677 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911003678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911003679 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 360911003680 Walker A/P-loop; other site 360911003681 ATP binding site [chemical binding]; other site 360911003682 Q-loop/lid; other site 360911003683 ABC transporter signature motif; other site 360911003684 Walker B; other site 360911003685 D-loop; other site 360911003686 H-loop/switch region; other site 360911003687 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 360911003688 putative active site [active] 360911003689 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 360911003690 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 360911003691 hinge; other site 360911003692 active site 360911003693 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 360911003694 active site 360911003695 intersubunit interactions; other site 360911003696 catalytic residue [active] 360911003697 hypothetical protein; Provisional; Region: PRK08185 360911003698 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 360911003699 intersubunit interface [polypeptide binding]; other site 360911003700 active site 360911003701 zinc binding site [ion binding]; other site 360911003702 Na+ binding site [ion binding]; other site 360911003703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003704 Response regulator receiver domain; Region: Response_reg; pfam00072 360911003705 active site 360911003706 phosphorylation site [posttranslational modification] 360911003707 intermolecular recognition site; other site 360911003708 dimerization interface [polypeptide binding]; other site 360911003709 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 360911003710 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 360911003711 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 360911003712 putative active site [active] 360911003713 putative FMN binding site [chemical binding]; other site 360911003714 putative substrate binding site [chemical binding]; other site 360911003715 putative catalytic residue [active] 360911003716 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 360911003717 NodB motif; other site 360911003718 active site 360911003719 catalytic site [active] 360911003720 Zn binding site [ion binding]; other site 360911003721 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911003722 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003723 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911003724 CTP synthetase; Validated; Region: pyrG; PRK05380 360911003725 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 360911003726 Catalytic site [active] 360911003727 active site 360911003728 UTP binding site [chemical binding]; other site 360911003729 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 360911003730 active site 360911003731 putative oxyanion hole; other site 360911003732 catalytic triad [active] 360911003733 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 360911003734 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 360911003735 heme-binding site [chemical binding]; other site 360911003736 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003737 dimer interface [polypeptide binding]; other site 360911003738 putative CheW interface [polypeptide binding]; other site 360911003739 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 360911003740 4Fe-4S binding domain; Region: Fer4; cl02805 360911003741 Cysteine-rich domain; Region: CCG; pfam02754 360911003742 Cysteine-rich domain; Region: CCG; pfam02754 360911003743 Predicted acetyltransferase [General function prediction only]; Region: COG3981 360911003744 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003745 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 360911003746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911003747 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003748 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 360911003749 conserved cys residue [active] 360911003750 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911003751 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911003752 Ca binding site [ion binding]; other site 360911003753 active site 360911003754 catalytic site [active] 360911003755 Predicted acetyltransferase [General function prediction only]; Region: COG3153 360911003756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911003757 Coenzyme A binding pocket [chemical binding]; other site 360911003758 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 360911003759 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911003760 DNA binding residues [nucleotide binding] 360911003761 dimer interface [polypeptide binding]; other site 360911003762 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 360911003763 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 360911003764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911003765 putative ADP-binding pocket [chemical binding]; other site 360911003766 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 360911003767 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360911003768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003769 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 360911003770 AMP-binding enzyme; Region: AMP-binding; cl15778 360911003771 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 360911003772 AMP-binding enzyme; Region: AMP-binding; cl15778 360911003773 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360911003774 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 360911003775 putative NAD(P) binding site [chemical binding]; other site 360911003776 active site 360911003777 putative substrate binding site [chemical binding]; other site 360911003778 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 360911003779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003780 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 360911003781 NAD(P) binding site [chemical binding]; other site 360911003782 homodimer interface [polypeptide binding]; other site 360911003783 substrate binding site [chemical binding]; other site 360911003784 active site 360911003785 Domain of unknown function (DUF897); Region: DUF897; cl01312 360911003786 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 360911003787 Arginase family; Region: Arginase; cl00306 360911003788 spermidine synthase; Provisional; Region: PRK00811 360911003789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911003790 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003791 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 360911003792 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 360911003793 Cl- selectivity filter; other site 360911003794 Cl- binding residues [ion binding]; other site 360911003795 pore gating glutamate residue; other site 360911003796 dimer interface [polypeptide binding]; other site 360911003797 cardiolipin synthetase; Reviewed; Region: PRK12452 360911003798 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911003799 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911003800 putative active site [active] 360911003801 catalytic site [active] 360911003802 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911003803 putative active site [active] 360911003804 catalytic site [active] 360911003805 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911003806 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 360911003807 YwhD family; Region: YwhD; pfam08741 360911003808 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 360911003809 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911003810 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 360911003811 active site turn [active] 360911003812 phosphorylation site [posttranslational modification] 360911003813 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911003814 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 360911003815 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 360911003816 putative active site [active] 360911003817 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003818 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360911003819 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360911003820 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360911003821 putative active site [active] 360911003822 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 360911003823 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 360911003824 active site 1 [active] 360911003825 dimer interface [polypeptide binding]; other site 360911003826 hexamer interface [polypeptide binding]; other site 360911003827 active site 2 [active] 360911003828 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 360911003829 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911003830 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911003831 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 360911003832 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911003833 Zn2+ binding site [ion binding]; other site 360911003834 Mg2+ binding site [ion binding]; other site 360911003835 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 360911003836 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 360911003837 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 360911003838 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 360911003839 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 360911003840 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 360911003841 lipoyl synthase; Provisional; Region: PRK05481 360911003842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911003843 FeS/SAM binding site; other site 360911003844 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 360911003845 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 360911003846 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 360911003847 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 360911003848 putative di-iron ligands [ion binding]; other site 360911003849 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 360911003850 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 360911003851 active site 360911003852 Na/Ca binding site [ion binding]; other site 360911003853 catalytic site [active] 360911003854 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 360911003855 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 360911003856 Helix-turn-helix domains; Region: HTH; cl00088 360911003857 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911003858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911003859 Ion channel; Region: Ion_trans_2; cl11596 360911003860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003861 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 360911003862 Predicted membrane protein [Function unknown]; Region: COG3766 360911003863 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 360911003864 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 360911003865 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 360911003866 heme-binding site [chemical binding]; other site 360911003867 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 360911003868 FAD binding pocket [chemical binding]; other site 360911003869 FAD binding motif [chemical binding]; other site 360911003870 phosphate binding motif [ion binding]; other site 360911003871 beta-alpha-beta structure motif; other site 360911003872 NAD binding pocket [chemical binding]; other site 360911003873 Heme binding pocket [chemical binding]; other site 360911003874 Helix-turn-helix domains; Region: HTH; cl00088 360911003875 Rrf2 family protein; Region: rrf2_super; TIGR00738 360911003876 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 360911003877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003878 Zn binding site [ion binding]; other site 360911003879 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 360911003880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003881 Zn binding site [ion binding]; other site 360911003882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911003883 non-specific DNA binding site [nucleotide binding]; other site 360911003884 salt bridge; other site 360911003885 sequence-specific DNA binding site [nucleotide binding]; other site 360911003886 putative efflux protein, MATE family; Region: matE; TIGR00797 360911003887 MatE; Region: MatE; cl10513 360911003888 MatE; Region: MatE; cl10513 360911003889 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 360911003890 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 360911003891 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911003892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911003893 dimerization interface [polypeptide binding]; other site 360911003894 putative DNA binding site [nucleotide binding]; other site 360911003895 putative Zn2+ binding site [ion binding]; other site 360911003896 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 360911003897 putative hydrophobic ligand binding site [chemical binding]; other site 360911003898 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 360911003899 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911003900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911003901 catalytic residue [active] 360911003902 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 360911003903 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911003904 putative NAD(P) binding site [chemical binding]; other site 360911003905 substrate binding site [chemical binding]; other site 360911003906 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003907 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911003908 active site 360911003909 metal binding site [ion binding]; metal-binding site 360911003910 Helix-turn-helix domains; Region: HTH; cl00088 360911003911 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003912 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911003913 active site 360911003914 metal binding site [ion binding]; metal-binding site 360911003915 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003916 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360911003917 TM-ABC transporter signature motif; other site 360911003918 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360911003919 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911003920 Walker A/P-loop; other site 360911003921 ATP binding site [chemical binding]; other site 360911003922 Q-loop/lid; other site 360911003923 ABC transporter signature motif; other site 360911003924 Walker B; other site 360911003925 D-loop; other site 360911003926 H-loop/switch region; other site 360911003927 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 360911003928 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 360911003929 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360911003930 putative ligand binding site [chemical binding]; other site 360911003931 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 360911003932 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 360911003933 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911003934 Phosphotransferase enzyme family; Region: APH; pfam01636 360911003935 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 360911003936 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 360911003937 dimer interface [polypeptide binding]; other site 360911003938 active site 360911003939 catalytic residue [active] 360911003940 metal binding site [ion binding]; metal-binding site 360911003941 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 360911003942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911003943 active site 360911003944 motif I; other site 360911003945 motif II; other site 360911003946 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 360911003947 intersubunit interface [polypeptide binding]; other site 360911003948 active site 360911003949 Zn2+ binding site [ion binding]; other site 360911003950 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 360911003951 Cupin domain; Region: Cupin_2; cl09118 360911003952 Integral membrane protein TerC family; Region: TerC; cl10468 360911003953 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 360911003954 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911003955 active site residue [active] 360911003956 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 360911003957 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 360911003958 Chlorite dismutase; Region: Chlor_dismutase; cl01280 360911003959 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911003960 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 360911003961 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 360911003962 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 360911003963 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 360911003964 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 360911003965 substrate binding site [chemical binding]; other site 360911003966 active site 360911003967 catalytic residues [active] 360911003968 heterodimer interface [polypeptide binding]; other site 360911003969 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 360911003970 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 360911003971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911003972 catalytic residue [active] 360911003973 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 360911003974 active site 360911003975 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 360911003976 active site 360911003977 ribulose/triose binding site [chemical binding]; other site 360911003978 phosphate binding site [ion binding]; other site 360911003979 substrate (anthranilate) binding pocket [chemical binding]; other site 360911003980 product (indole) binding pocket [chemical binding]; other site 360911003981 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 360911003982 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 360911003983 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 360911003984 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 360911003985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 360911003986 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911003987 Protein of unknown function (DUF423); Region: DUF423; cl01008 360911003988 Predicted membrane protein [Function unknown]; Region: COG2860 360911003989 UPF0126 domain; Region: UPF0126; pfam03458 360911003990 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 360911003991 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911003992 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911003993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911003994 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 360911003995 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911003996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911003997 catalytic residue [active] 360911003998 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 360911003999 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 360911004000 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 360911004001 tetramerization interface [polypeptide binding]; other site 360911004002 NAD(P) binding site [chemical binding]; other site 360911004003 catalytic residues [active] 360911004004 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 360911004005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004006 motif II; other site 360911004007 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911004008 active site residue [active] 360911004009 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 360911004010 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 360911004011 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 360911004012 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 360911004013 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 360911004014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911004015 metal binding site [ion binding]; metal-binding site 360911004016 active site 360911004017 I-site; other site 360911004018 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 360911004019 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911004020 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 360911004021 Walker A/P-loop; other site 360911004022 ATP binding site [chemical binding]; other site 360911004023 Q-loop/lid; other site 360911004024 ABC transporter signature motif; other site 360911004025 Walker B; other site 360911004026 D-loop; other site 360911004027 H-loop/switch region; other site 360911004028 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 360911004029 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911004030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911004031 Walker A/P-loop; other site 360911004032 ATP binding site [chemical binding]; other site 360911004033 Q-loop/lid; other site 360911004034 ABC transporter signature motif; other site 360911004035 Walker B; other site 360911004036 D-loop; other site 360911004037 H-loop/switch region; other site 360911004038 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 360911004039 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911004040 ligand binding site [chemical binding]; other site 360911004041 flexible hinge region; other site 360911004042 Helix-turn-helix domains; Region: HTH; cl00088 360911004043 putative switch regulator; other site 360911004044 non-specific DNA interactions [nucleotide binding]; other site 360911004045 DNA binding site [nucleotide binding] 360911004046 sequence specific DNA binding site [nucleotide binding]; other site 360911004047 putative cAMP binding site [chemical binding]; other site 360911004048 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 360911004049 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 360911004050 putative active site [active] 360911004051 putative catalytic site [active] 360911004052 carbamate kinase; Reviewed; Region: PRK12686 360911004053 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 360911004054 putative substrate binding site [chemical binding]; other site 360911004055 nucleotide binding site [chemical binding]; other site 360911004056 nucleotide binding site [chemical binding]; other site 360911004057 homodimer interface [polypeptide binding]; other site 360911004058 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 360911004059 ornithine carbamoyltransferase; Validated; Region: PRK02102 360911004060 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360911004061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004062 Amidinotransferase; Region: Amidinotransf; cl12043 360911004063 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 360911004064 MgtE intracellular N domain; Region: MgtE_N; cl15244 360911004065 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 360911004066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 360911004067 Divalent cation transporter; Region: MgtE; cl00786 360911004068 Sodium:solute symporter family; Region: SSF; cl00456 360911004069 putative transporter; Provisional; Region: PRK10484 360911004070 PAS fold; Region: PAS_3; pfam08447 360911004071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911004072 metal binding site [ion binding]; metal-binding site 360911004073 active site 360911004074 I-site; other site 360911004075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911004076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911004077 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911004078 short chain dehydrogenase; Provisional; Region: PRK06924 360911004079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004080 NAD(P) binding site [chemical binding]; other site 360911004081 active site 360911004082 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 360911004083 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 360911004084 NADP binding site [chemical binding]; other site 360911004085 dimer interface [polypeptide binding]; other site 360911004086 Heat induced stress protein YflT; Region: YflT; pfam11181 360911004087 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 360911004088 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911004089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911004090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911004091 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 360911004092 WYL domain; Region: WYL; cl14852 360911004093 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 360911004094 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 360911004095 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911004096 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 360911004097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911004098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911004099 DNA binding residues [nucleotide binding] 360911004100 Putative zinc-finger; Region: zf-HC2; cl15806 360911004101 putative anti-sigmaE protein; Provisional; Region: PRK13920 360911004102 Anti-sigma-K factor rskA; Region: RskA; pfam10099 360911004103 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911004104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004105 EamA-like transporter family; Region: EamA; cl01037 360911004106 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 360911004107 EamA-like transporter family; Region: EamA; cl01037 360911004108 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911004109 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911004110 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911004111 ABC transporter; Region: ABC_tran_2; pfam12848 360911004112 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911004113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004114 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911004115 active site 360911004116 motif I; other site 360911004117 motif II; other site 360911004118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004119 kynureninase; Region: kynureninase; TIGR01814 360911004120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911004121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911004122 catalytic residue [active] 360911004123 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 360911004124 Putative cyclase; Region: Cyclase; cl00814 360911004125 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911004126 active site 360911004127 MatE; Region: MatE; cl10513 360911004128 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911004129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911004130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 360911004131 active site 360911004132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911004133 Response regulator receiver domain; Region: Response_reg; pfam00072 360911004134 active site 360911004135 phosphorylation site [posttranslational modification] 360911004136 intermolecular recognition site; other site 360911004137 dimerization interface [polypeptide binding]; other site 360911004138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911004139 active site 360911004140 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 360911004141 Cupin domain; Region: Cupin_2; cl09118 360911004142 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 360911004143 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 360911004144 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 360911004145 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 360911004146 ligand binding site [chemical binding]; other site 360911004147 dimerization interface [polypeptide binding]; other site 360911004148 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360911004149 TM-ABC transporter signature motif; other site 360911004150 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360911004151 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 360911004152 Walker A/P-loop; other site 360911004153 ATP binding site [chemical binding]; other site 360911004154 Q-loop/lid; other site 360911004155 ABC transporter signature motif; other site 360911004156 Walker B; other site 360911004157 D-loop; other site 360911004158 H-loop/switch region; other site 360911004159 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 360911004160 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 360911004161 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360911004162 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 360911004163 substrate binding site [chemical binding]; other site 360911004164 dimer interface [polypeptide binding]; other site 360911004165 ATP binding site [chemical binding]; other site 360911004166 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911004167 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911004168 DNA binding site [nucleotide binding] 360911004169 domain linker motif; other site 360911004170 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 360911004171 dimerization interface [polypeptide binding]; other site 360911004172 ligand binding site [chemical binding]; other site 360911004173 sodium binding site [ion binding]; other site 360911004174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911004175 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911004176 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 360911004177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 360911004178 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911004179 OsmC-like protein; Region: OsmC; cl00767 360911004180 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 360911004181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 360911004182 PAS domain; Region: PAS_9; pfam13426 360911004183 putative active site [active] 360911004184 heme pocket [chemical binding]; other site 360911004185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911004186 metal binding site [ion binding]; metal-binding site 360911004187 active site 360911004188 I-site; other site 360911004189 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 360911004190 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911004191 NAD(P) binding site [chemical binding]; other site 360911004192 putative active site [active] 360911004193 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 360911004194 thiamine phosphate binding site [chemical binding]; other site 360911004195 active site 360911004196 pyrophosphate binding site [ion binding]; other site 360911004197 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 360911004198 dimer interface [polypeptide binding]; other site 360911004199 substrate binding site [chemical binding]; other site 360911004200 ATP binding site [chemical binding]; other site 360911004201 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 360911004202 substrate binding site [chemical binding]; other site 360911004203 multimerization interface [polypeptide binding]; other site 360911004204 ATP binding site [chemical binding]; other site 360911004205 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 360911004206 Ion channel; Region: Ion_trans_2; cl11596 360911004207 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 360911004208 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 360911004209 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360911004210 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 360911004211 nudix motif; other site 360911004212 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 360911004213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004214 motif II; other site 360911004215 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 360911004216 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 360911004217 NAD(P) binding site [chemical binding]; other site 360911004218 catalytic residues [active] 360911004219 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 360911004220 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 360911004221 PhnA protein; Region: PhnA; pfam03831 360911004222 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 360911004223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004224 Coenzyme A binding pocket [chemical binding]; other site 360911004225 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 360911004226 dimerization interface [polypeptide binding]; other site 360911004227 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 360911004228 active site 360911004229 substrate binding site [chemical binding]; other site 360911004230 ATP binding site [chemical binding]; other site 360911004231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911004232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911004233 active site 360911004234 catalytic tetrad [active] 360911004235 Pirin-related protein [General function prediction only]; Region: COG1741 360911004236 Cupin domain; Region: Cupin_2; cl09118 360911004237 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 360911004238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004239 Coenzyme A binding pocket [chemical binding]; other site 360911004240 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 360911004241 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 360911004242 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911004243 hypothetical protein; Provisional; Region: PRK01346 360911004244 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911004245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 360911004246 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911004247 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911004248 nudix motif; other site 360911004249 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 360911004250 putative dimer interface [polypeptide binding]; other site 360911004251 catalytic triad [active] 360911004252 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 360911004253 classical (c) SDRs; Region: SDR_c; cd05233 360911004254 NAD(P) binding site [chemical binding]; other site 360911004255 active site 360911004256 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911004257 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911004258 nudix motif; other site 360911004259 Uncharacterized conserved protein [Function unknown]; Region: COG3268 360911004260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004261 NAD(P) binding site [chemical binding]; other site 360911004262 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911004263 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 360911004264 Zn binding site [ion binding]; other site 360911004265 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 360911004266 Zn binding site [ion binding]; other site 360911004267 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911004268 Helix-turn-helix domains; Region: HTH; cl00088 360911004269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004270 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 360911004271 Coenzyme A binding pocket [chemical binding]; other site 360911004272 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 360911004273 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 360911004274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911004275 binding surface 360911004276 TPR motif; other site 360911004277 TPR repeat; Region: TPR_11; pfam13414 360911004278 Protein of unknown function (DUF402); Region: DUF402; cl00979 360911004279 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911004280 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 360911004281 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911004282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004283 Walker A motif; other site 360911004284 ATP binding site [chemical binding]; other site 360911004285 Walker B motif; other site 360911004286 arginine finger; other site 360911004287 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 360911004288 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 360911004289 active site 360911004290 ATP binding site [chemical binding]; other site 360911004291 substrate binding site [chemical binding]; other site 360911004292 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 360911004293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911004294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004295 Coenzyme A binding pocket [chemical binding]; other site 360911004296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004297 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911004298 active site 360911004299 metal binding site [ion binding]; metal-binding site 360911004300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004301 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911004302 active site 360911004303 metal binding site [ion binding]; metal-binding site 360911004304 Sulfatase; Region: Sulfatase; cl10460 360911004305 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 360911004306 dimer interface [polypeptide binding]; other site 360911004307 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 360911004308 dimer interface [polypeptide binding]; other site 360911004309 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 360911004310 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 360911004311 Helix-turn-helix domains; Region: HTH; cl00088 360911004312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004313 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 360911004314 Protein of unknown function (DUF975); Region: DUF975; cl10504 360911004315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 360911004316 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 360911004317 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 360911004318 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 360911004319 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 360911004320 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 360911004321 glutaminase active site [active] 360911004322 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 360911004323 dimer interface [polypeptide binding]; other site 360911004324 active site 360911004325 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 360911004326 dimer interface [polypeptide binding]; other site 360911004327 active site 360911004328 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 360911004329 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 360911004330 active site 360911004331 substrate binding site [chemical binding]; other site 360911004332 metal binding site [ion binding]; metal-binding site 360911004333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 360911004334 YbbR-like protein; Region: YbbR; pfam07949 360911004335 YbbR-like protein; Region: YbbR; pfam07949 360911004336 Uncharacterized conserved protein [Function unknown]; Region: COG1624 360911004337 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 360911004338 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 360911004339 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 360911004340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911004341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911004342 DNA binding residues [nucleotide binding] 360911004343 Arginase family; Region: Arginase; cl00306 360911004344 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 360911004345 Domain of unknown function DUF59; Region: DUF59; cl00941 360911004346 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 360911004347 Walker A motif; other site 360911004348 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 360911004349 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 360911004350 23S rRNA interface [nucleotide binding]; other site 360911004351 L3 interface [polypeptide binding]; other site 360911004352 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 360911004353 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 360911004354 dimerization interface 3.5A [polypeptide binding]; other site 360911004355 active site 360911004356 Cobalt transport protein; Region: CbiQ; cl00463 360911004357 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 360911004358 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 360911004359 Walker A/P-loop; other site 360911004360 ATP binding site [chemical binding]; other site 360911004361 Q-loop/lid; other site 360911004362 ABC transporter signature motif; other site 360911004363 Walker B; other site 360911004364 D-loop; other site 360911004365 H-loop/switch region; other site 360911004366 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 360911004367 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 360911004368 Walker A/P-loop; other site 360911004369 ATP binding site [chemical binding]; other site 360911004370 Q-loop/lid; other site 360911004371 ABC transporter signature motif; other site 360911004372 Walker B; other site 360911004373 D-loop; other site 360911004374 H-loop/switch region; other site 360911004375 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 360911004376 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 360911004377 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 360911004378 alphaNTD homodimer interface [polypeptide binding]; other site 360911004379 alphaNTD - beta interaction site [polypeptide binding]; other site 360911004380 alphaNTD - beta' interaction site [polypeptide binding]; other site 360911004381 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 360911004382 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 360911004383 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 360911004384 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 360911004385 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 360911004386 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 360911004387 rRNA binding site [nucleotide binding]; other site 360911004388 predicted 30S ribosome binding site; other site 360911004389 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 360911004390 active site 360911004391 adenylate kinase; Reviewed; Region: adk; PRK00279 360911004392 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 360911004393 AMP-binding site [chemical binding]; other site 360911004394 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 360911004395 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 360911004396 SecY translocase; Region: SecY; pfam00344 360911004397 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 360911004398 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 360911004399 23S rRNA binding site [nucleotide binding]; other site 360911004400 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 360911004401 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 360911004402 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 360911004403 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 360911004404 23S rRNA interface [nucleotide binding]; other site 360911004405 5S rRNA interface [nucleotide binding]; other site 360911004406 L27 interface [polypeptide binding]; other site 360911004407 L5 interface [polypeptide binding]; other site 360911004408 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 360911004409 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 360911004410 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 360911004411 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 360911004412 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 360911004413 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 360911004414 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 360911004415 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 360911004416 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 360911004417 KOW motif; Region: KOW; cl00354 360911004418 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 360911004419 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 360911004420 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 360911004421 23S rRNA interface [nucleotide binding]; other site 360911004422 putative translocon interaction site; other site 360911004423 signal recognition particle (SRP54) interaction site; other site 360911004424 L23 interface [polypeptide binding]; other site 360911004425 trigger factor interaction site; other site 360911004426 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 360911004427 23S rRNA interface [nucleotide binding]; other site 360911004428 5S rRNA interface [nucleotide binding]; other site 360911004429 putative antibiotic binding site [chemical binding]; other site 360911004430 L25 interface [polypeptide binding]; other site 360911004431 L27 interface [polypeptide binding]; other site 360911004432 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 360911004433 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 360911004434 G-X-X-G motif; other site 360911004435 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 360911004436 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 360911004437 putative translocon binding site; other site 360911004438 protein-rRNA interface [nucleotide binding]; other site 360911004439 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 360911004440 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 360911004441 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 360911004442 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 360911004443 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 360911004444 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 360911004445 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 360911004446 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 360911004447 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 360911004448 metal binding triad [ion binding]; metal-binding site 360911004449 elongation factor Tu; Reviewed; Region: PRK00049 360911004450 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 360911004451 G1 box; other site 360911004452 GEF interaction site [polypeptide binding]; other site 360911004453 GTP/Mg2+ binding site [chemical binding]; other site 360911004454 Switch I region; other site 360911004455 G2 box; other site 360911004456 G3 box; other site 360911004457 Switch II region; other site 360911004458 G4 box; other site 360911004459 G5 box; other site 360911004460 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 360911004461 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 360911004462 Antibiotic Binding Site [chemical binding]; other site 360911004463 elongation factor G; Reviewed; Region: PRK00007 360911004464 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 360911004465 G1 box; other site 360911004466 putative GEF interaction site [polypeptide binding]; other site 360911004467 GTP/Mg2+ binding site [chemical binding]; other site 360911004468 Switch I region; other site 360911004469 G2 box; other site 360911004470 G3 box; other site 360911004471 Switch II region; other site 360911004472 G4 box; other site 360911004473 G5 box; other site 360911004474 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 360911004475 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 360911004476 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 360911004477 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 360911004478 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 360911004479 16S rRNA interaction site [nucleotide binding]; other site 360911004480 streptomycin interaction site [chemical binding]; other site 360911004481 23S rRNA interaction site [nucleotide binding]; other site 360911004482 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 360911004483 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 360911004484 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 360911004485 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 360911004486 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 360911004487 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 360911004488 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 360911004489 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 360911004490 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 360911004491 G-loop; other site 360911004492 DNA binding site [nucleotide binding] 360911004493 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 360911004494 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 360911004495 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 360911004496 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 360911004497 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 360911004498 RPB12 interaction site [polypeptide binding]; other site 360911004499 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 360911004500 RPB10 interaction site [polypeptide binding]; other site 360911004501 RPB1 interaction site [polypeptide binding]; other site 360911004502 RPB11 interaction site [polypeptide binding]; other site 360911004503 RPB3 interaction site [polypeptide binding]; other site 360911004504 RPB12 interaction site [polypeptide binding]; other site 360911004505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911004506 S-adenosylmethionine binding site [chemical binding]; other site 360911004507 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 360911004508 peripheral dimer interface [polypeptide binding]; other site 360911004509 core dimer interface [polypeptide binding]; other site 360911004510 L10 interface [polypeptide binding]; other site 360911004511 L11 interface [polypeptide binding]; other site 360911004512 putative EF-Tu interaction site [polypeptide binding]; other site 360911004513 putative EF-G interaction site [polypeptide binding]; other site 360911004514 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 360911004515 23S rRNA interface [nucleotide binding]; other site 360911004516 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 360911004517 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 360911004518 mRNA/rRNA interface [nucleotide binding]; other site 360911004519 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 360911004520 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 360911004521 23S rRNA interface [nucleotide binding]; other site 360911004522 L7/L12 interface [polypeptide binding]; other site 360911004523 putative thiostrepton binding site; other site 360911004524 L25 interface [polypeptide binding]; other site 360911004525 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 360911004526 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 360911004527 putative homodimer interface [polypeptide binding]; other site 360911004528 KOW motif; Region: KOW; cl00354 360911004529 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 360911004530 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 360911004531 RNA polymerase factor sigma-70; Validated; Region: PRK08295 360911004532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911004533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 360911004534 YacP-like NYN domain; Region: NYN_YacP; cl01491 360911004535 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 360911004536 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 360911004537 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 360911004538 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 360911004539 active site 360911004540 metal binding site [ion binding]; metal-binding site 360911004541 dimerization interface [polypeptide binding]; other site 360911004542 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 360911004543 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 360911004544 active site 360911004545 HIGH motif; other site 360911004546 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 360911004547 KMSKS motif; other site 360911004548 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 360911004549 serine O-acetyltransferase; Region: cysE; TIGR01172 360911004550 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 360911004551 trimer interface [polypeptide binding]; other site 360911004552 active site 360911004553 substrate binding site [chemical binding]; other site 360911004554 CoA binding site [chemical binding]; other site 360911004555 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 360911004556 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 360911004557 active site 360911004558 HIGH motif; other site 360911004559 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 360911004560 active site 360911004561 KMSKS motif; other site 360911004562 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 360911004563 homotrimer interaction site [polypeptide binding]; other site 360911004564 zinc binding site [ion binding]; other site 360911004565 CDP-binding sites; other site 360911004566 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 360911004567 substrate binding site; other site 360911004568 dimer interface; other site 360911004569 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 360911004570 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 360911004571 putative active site [active] 360911004572 DNA repair protein RadA; Provisional; Region: PRK11823 360911004573 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 360911004574 Walker A motif/ATP binding site; other site 360911004575 ATP binding site [chemical binding]; other site 360911004576 Walker B motif; other site 360911004577 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 360911004578 Clp protease ATP binding subunit; Region: clpC; CHL00095 360911004579 Clp amino terminal domain; Region: Clp_N; pfam02861 360911004580 Clp amino terminal domain; Region: Clp_N; pfam02861 360911004581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004582 Walker A motif; other site 360911004583 ATP binding site [chemical binding]; other site 360911004584 Walker B motif; other site 360911004585 arginine finger; other site 360911004586 UvrB/uvrC motif; Region: UVR; pfam02151 360911004587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004588 Walker A motif; other site 360911004589 ATP binding site [chemical binding]; other site 360911004590 Walker B motif; other site 360911004591 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 360911004592 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 360911004593 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 360911004594 ADP binding site [chemical binding]; other site 360911004595 phosphagen binding site; other site 360911004596 substrate specificity loop; other site 360911004597 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 360911004598 UvrB/uvrC motif; Region: UVR; pfam02151 360911004599 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 360911004600 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 360911004601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911004602 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 360911004603 dimer interface [polypeptide binding]; other site 360911004604 putative anticodon binding site; other site 360911004605 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 360911004606 motif 1; other site 360911004607 active site 360911004608 motif 2; other site 360911004609 motif 3; other site 360911004610 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 360911004611 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 360911004612 FMN binding site [chemical binding]; other site 360911004613 active site 360911004614 catalytic residues [active] 360911004615 substrate binding site [chemical binding]; other site 360911004616 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 360911004617 catalytic center binding site [active] 360911004618 ATP binding site [chemical binding]; other site 360911004619 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 360911004620 homooctamer interface [polypeptide binding]; other site 360911004621 active site 360911004622 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 360911004623 dihydropteroate synthase; Region: DHPS; TIGR01496 360911004624 substrate binding pocket [chemical binding]; other site 360911004625 dimer interface [polypeptide binding]; other site 360911004626 inhibitor binding site; inhibition site 360911004627 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 360911004628 homodimer interface [polypeptide binding]; other site 360911004629 substrate-cofactor binding pocket; other site 360911004630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911004631 catalytic residue [active] 360911004632 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 360911004633 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 360911004634 glutamine binding [chemical binding]; other site 360911004635 catalytic triad [active] 360911004636 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 360911004637 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 360911004638 chorismate binding enzyme; Region: Chorismate_bind; cl10555 360911004639 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 360911004640 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 360911004641 dimer interface [polypeptide binding]; other site 360911004642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911004643 catalytic residue [active] 360911004644 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 360911004645 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 360911004646 dimerization interface [polypeptide binding]; other site 360911004647 domain crossover interface; other site 360911004648 redox-dependent activation switch; other site 360911004649 Type III pantothenate kinase; Region: Pan_kinase; cl09130 360911004650 FtsH Extracellular; Region: FtsH_ext; pfam06480 360911004651 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 360911004652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004653 Walker A motif; other site 360911004654 ATP binding site [chemical binding]; other site 360911004655 Walker B motif; other site 360911004656 arginine finger; other site 360911004657 Peptidase family M41; Region: Peptidase_M41; pfam01434 360911004658 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911004659 active site 360911004660 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 360911004661 Ligand Binding Site [chemical binding]; other site 360911004662 B3/4 domain; Region: B3_4; cl11458 360911004663 Predicted membrane protein [Function unknown]; Region: COG1511 360911004664 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 360911004665 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 360911004666 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 360911004667 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 360911004668 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911004669 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 360911004670 RNA binding site [nucleotide binding]; other site 360911004671 hypothetical protein; Provisional; Region: PRK08582 360911004672 Septum formation initiator; Region: DivIC; cl11433 360911004673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911004674 RNA binding surface [nucleotide binding]; other site 360911004675 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 360911004676 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 360911004677 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 360911004678 MatE; Region: MatE; cl10513 360911004679 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 360911004680 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 360911004681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911004682 ATP binding site [chemical binding]; other site 360911004683 putative Mg++ binding site [ion binding]; other site 360911004684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911004685 nucleotide binding region [chemical binding]; other site 360911004686 ATP-binding site [chemical binding]; other site 360911004687 TRCF domain; Region: TRCF; cl04088 360911004688 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 360911004689 putative active site [active] 360911004690 catalytic residue [active] 360911004691 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 360911004692 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 360911004693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911004694 active site 360911004695 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 360911004696 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 360911004697 Substrate binding site; other site 360911004698 Mg++ binding site; other site 360911004699 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 360911004700 active site 360911004701 substrate binding site [chemical binding]; other site 360911004702 CoA binding site [chemical binding]; other site 360911004703 SpoVG; Region: SpoVG; cl00915 360911004704 pur operon repressor; Provisional; Region: PRK09213 360911004705 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 360911004706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911004707 active site 360911004708 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 360911004709 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 360911004710 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 360911004711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004712 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 360911004713 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 360911004714 putative active site [active] 360911004715 putative metal binding site [ion binding]; other site 360911004716 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 360911004717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 360911004718 Domain of unknown function (DUF348); Region: DUF348; pfam03990 360911004719 Domain of unknown function (DUF348); Region: DUF348; pfam03990 360911004720 3D domain; Region: 3D; cl01439 360911004721 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 360911004722 active site 360911004723 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 360911004724 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 360911004725 active site 360911004726 HIGH motif; other site 360911004727 KMSKS motif; other site 360911004728 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 360911004729 tRNA binding surface [nucleotide binding]; other site 360911004730 anticodon binding site; other site 360911004731 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 360911004732 dimer interface [polypeptide binding]; other site 360911004733 putative tRNA-binding site [nucleotide binding]; other site 360911004734 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 360911004735 Predicted methyltransferases [General function prediction only]; Region: COG0313 360911004736 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 360911004737 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 360911004738 GIY-YIG motif/motif A; other site 360911004739 putative active site [active] 360911004740 putative metal binding site [ion binding]; other site 360911004741 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 360911004742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911004743 S-adenosylmethionine binding site [chemical binding]; other site 360911004744 TSC-22/dip/bun family; Region: TSC22; cl01853 360911004745 PSP1 C-terminal conserved region; Region: PSP1; cl00770 360911004746 DNA polymerase III subunit delta'; Validated; Region: PRK08058 360911004747 Nitrogen regulatory protein P-II; Region: P-II; cl00412 360911004748 thymidylate kinase; Validated; Region: tmk; PRK00698 360911004749 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 360911004750 TMP-binding site; other site 360911004751 ATP-binding site [chemical binding]; other site 360911004752 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 360911004753 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911004754 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911004755 catalytic residue [active] 360911004756 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 360911004757 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 360911004758 recombination protein RecR; Reviewed; Region: recR; PRK00076 360911004759 RecR protein; Region: RecR; pfam02132 360911004760 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 360911004761 putative active site [active] 360911004762 putative metal-binding site [ion binding]; other site 360911004763 tetramer interface [polypeptide binding]; other site 360911004764 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 360911004765 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 360911004766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004767 Walker A motif; other site 360911004768 ATP binding site [chemical binding]; other site 360911004769 Walker B motif; other site 360911004770 arginine finger; other site 360911004771 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 360911004772 nucleoside/Zn binding site; other site 360911004773 dimer interface [polypeptide binding]; other site 360911004774 catalytic motif [active] 360911004775 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 360911004776 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 360911004777 Substrate-binding site [chemical binding]; other site 360911004778 Substrate specificity [chemical binding]; other site 360911004779 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 360911004780 Substrate-binding site [chemical binding]; other site 360911004781 Substrate specificity [chemical binding]; other site 360911004782 seryl-tRNA synthetase; Provisional; Region: PRK05431 360911004783 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 360911004784 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 360911004785 dimer interface [polypeptide binding]; other site 360911004786 active site 360911004787 motif 1; other site 360911004788 motif 2; other site 360911004789 motif 3; other site 360911004790 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 360911004791 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911004792 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 360911004793 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 360911004794 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 360911004795 predicted active site [active] 360911004796 catalytic triad [active] 360911004797 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 360911004798 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 360911004799 phosphate binding site [ion binding]; other site 360911004800 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 360911004801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911004802 DNA-binding site [nucleotide binding]; DNA binding site 360911004803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911004804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911004805 homodimer interface [polypeptide binding]; other site 360911004806 catalytic residue [active] 360911004807 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 360911004808 active site 360911004809 catalytic site [active] 360911004810 Bacterial Ig-like domain; Region: Big_5; cl01012 360911004811 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 360911004812 carbohydrate binding site [chemical binding]; other site 360911004813 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 360911004814 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 360911004815 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 360911004816 active site 360911004817 catalytic site [active] 360911004818 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 360911004819 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 360911004820 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 360911004821 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 360911004822 active site 360911004823 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 360911004824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911004825 DNA gyrase subunit A; Validated; Region: PRK05560 360911004826 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 360911004827 CAP-like domain; other site 360911004828 active site 360911004829 primary dimer interface [polypeptide binding]; other site 360911004830 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911004831 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911004832 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911004833 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911004834 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911004835 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 360911004836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911004837 Mg2+ binding site [ion binding]; other site 360911004838 G-X-G motif; other site 360911004839 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 360911004840 anchoring element; other site 360911004841 dimer interface [polypeptide binding]; other site 360911004842 ATP binding site [chemical binding]; other site 360911004843 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 360911004844 active site 360911004845 putative metal-binding site [ion binding]; other site 360911004846 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 360911004847 recombination protein F; Reviewed; Region: recF; PRK00064 360911004848 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 360911004849 Walker A/P-loop; other site 360911004850 ATP binding site [chemical binding]; other site 360911004851 Q-loop/lid; other site 360911004852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911004853 ABC transporter signature motif; other site 360911004854 Walker B; other site 360911004855 D-loop; other site 360911004856 H-loop/switch region; other site 360911004857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 360911004858 DNA polymerase III subunit beta; Validated; Region: PRK05643 360911004859 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 360911004860 putative DNA binding surface [nucleotide binding]; other site 360911004861 dimer interface [polypeptide binding]; other site 360911004862 beta-clamp/clamp loader binding surface; other site 360911004863 beta-clamp/translesion DNA polymerase binding surface; other site 360911004864 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 360911004865 DnaA N-terminal domain; Region: DnaA_N; pfam11638 360911004866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004867 Walker A motif; other site 360911004868 ATP binding site [chemical binding]; other site 360911004869 Walker B motif; other site 360911004870 arginine finger; other site 360911004871 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 360911004872 DnaA box-binding interface [nucleotide binding]; other site 360911004873 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 360911004874 Ribonuclease P; Region: Ribonuclease_P; cl00457 360911004875 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 360911004876 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 360911004877 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 360911004878 active site 360911004879 NTP binding site [chemical binding]; other site 360911004880 metal binding triad [ion binding]; metal-binding site 360911004881 antibiotic binding site [chemical binding]; other site 360911004882 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 360911004883 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 360911004884 trmE is a tRNA modification GTPase; Region: trmE; cd04164 360911004885 G1 box; other site 360911004886 GTP/Mg2+ binding site [chemical binding]; other site 360911004887 Switch I region; other site 360911004888 G2 box; other site 360911004889 Switch II region; other site 360911004890 G3 box; other site 360911004891 G4 box; other site 360911004892 G5 box; other site 360911004893 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 360911004894 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 360911004895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004897 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 360911004898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 360911004899 ParB-like partition proteins; Region: parB_part; TIGR00180 360911004900 ParB-like nuclease domain; Region: ParBc; cl02129 360911004901 ParB-like nuclease domain; Region: ParBc; cl02129 360911004902 ParB-like partition proteins; Region: parB_part; TIGR00180 360911004903 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 360911004904 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 360911004905 Mechanosensitive ion channel; Region: MS_channel; pfam00924 360911004906 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 360911004907 GTP-binding protein YchF; Reviewed; Region: PRK09601 360911004908 YchF GTPase; Region: YchF; cd01900 360911004909 G1 box; other site 360911004910 GTP/Mg2+ binding site [chemical binding]; other site 360911004911 Switch I region; other site 360911004912 G2 box; other site 360911004913 Switch II region; other site 360911004914 G3 box; other site 360911004915 G4 box; other site 360911004916 G5 box; other site 360911004917 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 360911004918 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 360911004919 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 360911004920 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 360911004921 dimer interface [polypeptide binding]; other site 360911004922 ssDNA binding site [nucleotide binding]; other site 360911004923 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911004924 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 360911004925 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 360911004926 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 360911004927 DHH family; Region: DHH; pfam01368 360911004928 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 360911004929 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 360911004930 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 360911004931 replicative DNA helicase; Provisional; Region: PRK05748 360911004932 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 360911004933 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 360911004934 Walker A motif; other site 360911004935 ATP binding site [chemical binding]; other site 360911004936 Walker B motif; other site 360911004937 DNA binding loops [nucleotide binding] 360911004938 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 360911004939 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 360911004940 GDP-binding site [chemical binding]; other site 360911004941 ACT binding site; other site 360911004942 IMP binding site; other site 360911004943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911004944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911004945 active site 360911004946 phosphorylation site [posttranslational modification] 360911004947 intermolecular recognition site; other site 360911004948 dimerization interface [polypeptide binding]; other site 360911004949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911004950 DNA binding site [nucleotide binding] 360911004951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 360911004952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911004953 dimerization interface [polypeptide binding]; other site 360911004954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 360911004955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911004956 dimer interface [polypeptide binding]; other site 360911004957 phosphorylation site [posttranslational modification] 360911004958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911004959 ATP binding site [chemical binding]; other site 360911004960 Mg2+ binding site [ion binding]; other site 360911004961 G-X-G motif; other site 360911004962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 360911004963 YycH protein; Region: YycH; pfam07435 360911004964 YycH protein; Region: YycI; cl02015 360911004965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911004966 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 360911004967 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911004968 protein binding site [polypeptide binding]; other site 360911004969 YyzF-like protein; Region: YyzF; cl15733 360911004970 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 360911004971 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 360911004972 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911004973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004974 Coenzyme A binding pocket [chemical binding]; other site 360911004975 Phosphopantetheine attachment site; Region: PP-binding; cl09936 360911004976 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 360911004977 AMP-binding enzyme; Region: AMP-binding; cl15778 360911004978 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 360911004979 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911004980 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 360911004981 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 360911004982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911004983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911004984 DNA binding residues [nucleotide binding] 360911004985 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 360911004986 Protein of unknown function DUF262; Region: DUF262; cl14890 360911004987 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 360911004988 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 360911004989 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911004990 ATP binding site [chemical binding]; other site 360911004991 Mg++ binding site [ion binding]; other site 360911004992 motif III; other site 360911004993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911004994 nucleotide binding region [chemical binding]; other site 360911004995 ATP-binding site [chemical binding]; other site 360911004996 DbpA RNA binding domain; Region: DbpA; pfam03880 360911004997 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 360911004998 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911004999 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 360911005000 Fibronectin type III-like domain; Region: Fn3-like; cl15273 360911005001 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 360911005002 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 360911005003 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 360911005004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911005005 motif II; other site 360911005006 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911005007 Scramblase; Region: Scramblase; cl02043 360911005008 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 360911005009 nudix motif; other site 360911005010 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 360911005011 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 360911005012 active site 360911005013 catalytic residues [active] 360911005014 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 360911005015 Predicted integral membrane protein [Function unknown]; Region: COG0392 360911005016 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 360911005017 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 360911005018 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 360911005019 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 360911005020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005022 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 360911005023 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360911005024 endonuclease III; Region: ENDO3c; smart00478 360911005025 minor groove reading motif; other site 360911005026 helix-hairpin-helix signature motif; other site 360911005027 substrate binding pocket [chemical binding]; other site 360911005028 active site 360911005029 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 360911005030 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 360911005031 DNA binding site [nucleotide binding] 360911005032 active site 360911005033 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 360911005034 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360911005035 catalytic core [active] 360911005036 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 360911005037 PLD-like domain; Region: PLDc_2; pfam13091 360911005038 putative homodimer interface [polypeptide binding]; other site 360911005039 putative active site [active] 360911005040 catalytic site [active] 360911005041 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911005042 ATP binding site [chemical binding]; other site 360911005043 putative Mg++ binding site [ion binding]; other site 360911005044 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911005045 nucleotide binding region [chemical binding]; other site 360911005046 ATP-binding site [chemical binding]; other site 360911005047 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 360911005048 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 360911005049 active site 360911005050 8-oxo-dGMP binding site [chemical binding]; other site 360911005051 nudix motif; other site 360911005052 metal binding site [ion binding]; metal-binding site 360911005053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005054 Predicted dehydrogenase [General function prediction only]; Region: COG0579 360911005055 PAS fold; Region: PAS_4; pfam08448 360911005056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911005057 putative active site [active] 360911005058 heme pocket [chemical binding]; other site 360911005059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911005060 dimer interface [polypeptide binding]; other site 360911005061 putative CheW interface [polypeptide binding]; other site 360911005062 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 360911005063 Helix-turn-helix domains; Region: HTH; cl00088 360911005064 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 360911005065 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 360911005066 NAD binding site [chemical binding]; other site 360911005067 substrate binding site [chemical binding]; other site 360911005068 catalytic Zn binding site [ion binding]; other site 360911005069 tetramer interface [polypeptide binding]; other site 360911005070 structural Zn binding site [ion binding]; other site 360911005071 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 360911005072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911005073 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 360911005074 Walker A/P-loop; other site 360911005075 ATP binding site [chemical binding]; other site 360911005076 Q-loop/lid; other site 360911005077 ABC transporter signature motif; other site 360911005078 Walker B; other site 360911005079 D-loop; other site 360911005080 H-loop/switch region; other site 360911005081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 360911005082 NMT1-like family; Region: NMT1_2; cl15260 360911005083 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 360911005084 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911005085 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911005086 active site 360911005087 catalytic tetrad [active] 360911005088 Helix-turn-helix domains; Region: HTH; cl00088 360911005089 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 360911005090 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 360911005091 catalytic residue [active] 360911005092 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 360911005093 catalytic residues [active] 360911005094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911005095 peroxiredoxin; Region: AhpC; TIGR03137 360911005096 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 360911005097 dimer interface [polypeptide binding]; other site 360911005098 decamer (pentamer of dimers) interface [polypeptide binding]; other site 360911005099 catalytic triad [active] 360911005100 peroxidatic and resolving cysteines [active] 360911005101 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 360911005102 heat shock protein 90; Provisional; Region: PRK05218 360911005103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005104 ATP binding site [chemical binding]; other site 360911005105 Mg2+ binding site [ion binding]; other site 360911005106 G-X-G motif; other site 360911005107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911005108 Helix-turn-helix domains; Region: HTH; cl00088 360911005109 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 360911005110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005111 NAD(P) binding site [chemical binding]; other site 360911005112 active site 360911005113 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 360911005114 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911005115 RNA binding surface [nucleotide binding]; other site 360911005116 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 360911005117 probable active site [active] 360911005118 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 360911005119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 360911005120 Nucleoside recognition; Region: Gate; cl00486 360911005121 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 360911005122 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 360911005123 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 360911005124 PAS fold; Region: PAS_4; pfam08448 360911005125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911005126 metal binding site [ion binding]; metal-binding site 360911005127 active site 360911005128 I-site; other site 360911005129 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911005130 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 360911005131 GAF domain; Region: GAF; cl15785 360911005132 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911005133 metal binding site [ion binding]; metal-binding site 360911005134 active site 360911005135 I-site; other site 360911005136 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911005138 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911005139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005140 Coenzyme A binding pocket [chemical binding]; other site 360911005141 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 360911005142 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 360911005143 active site 360911005144 PAS fold; Region: PAS_4; pfam08448 360911005145 PAS domain S-box; Region: sensory_box; TIGR00229 360911005146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 360911005147 PAS domain S-box; Region: sensory_box; TIGR00229 360911005148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 360911005149 PAS domain S-box; Region: sensory_box; TIGR00229 360911005150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911005151 putative active site [active] 360911005152 heme pocket [chemical binding]; other site 360911005153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911005154 metal binding site [ion binding]; metal-binding site 360911005155 active site 360911005156 I-site; other site 360911005157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911005158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911005159 putative substrate translocation pore; other site 360911005160 hydroperoxidase II; Provisional; Region: katE; PRK11249 360911005161 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 360911005162 tetramer interface [polypeptide binding]; other site 360911005163 heme binding pocket [chemical binding]; other site 360911005164 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 360911005165 domain interactions; other site 360911005166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005167 FAD dependent oxidoreductase; Region: DAO; pfam01266 360911005168 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 360911005169 Lamin Tail Domain; Region: LTD; pfam00932 360911005170 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 360911005171 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 360911005172 generic binding surface I; other site 360911005173 generic binding surface II; other site 360911005174 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 360911005175 putative active site [active] 360911005176 putative catalytic site [active] 360911005177 putative Mg binding site IVb [ion binding]; other site 360911005178 putative phosphate binding site [ion binding]; other site 360911005179 putative DNA binding site [nucleotide binding]; other site 360911005180 putative Mg binding site IVa [ion binding]; other site 360911005181 Esterase/lipase [General function prediction only]; Region: COG1647 360911005182 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911005183 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911005184 Ca binding site [ion binding]; other site 360911005185 active site 360911005186 catalytic site [active] 360911005187 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 360911005188 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911005189 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911005190 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 360911005191 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 360911005192 putative dimer interface [polypeptide binding]; other site 360911005193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911005194 ligand binding site [chemical binding]; other site 360911005195 Zn binding site [ion binding]; other site 360911005196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005197 G1 box; other site 360911005198 GTP/Mg2+ binding site [chemical binding]; other site 360911005199 G2 box; other site 360911005200 Switch I region; other site 360911005201 G3 box; other site 360911005202 Switch II region; other site 360911005203 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 360911005204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005205 G1 box; other site 360911005206 GTP/Mg2+ binding site [chemical binding]; other site 360911005207 G2 box; other site 360911005208 Switch I region; other site 360911005209 G3 box; other site 360911005210 Switch II region; other site 360911005211 G4 box; other site 360911005212 Domain of unknown function (DUF697); Region: DUF697; cl12064 360911005213 glyoxylate reductase; Reviewed; Region: PRK13243 360911005214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005215 Heat induced stress protein YflT; Region: YflT; pfam11181 360911005216 Heat induced stress protein YflT; Region: YflT; pfam11181 360911005217 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 360911005218 active site 360911005219 dimer interfaces [polypeptide binding]; other site 360911005220 catalytic residues [active] 360911005221 Conserved TM helix; Region: TM_helix; pfam05552 360911005222 Conserved TM helix; Region: TM_helix; pfam05552 360911005223 Conserved TM helix; Region: TM_helix; pfam05552 360911005224 Conserved TM helix; Region: TM_helix; pfam05552 360911005225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911005226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911005227 Zn2+ binding site [ion binding]; other site 360911005228 Mg2+ binding site [ion binding]; other site 360911005229 AzlC protein; Region: AzlC; cl00570 360911005230 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 360911005231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 360911005232 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 360911005233 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 360911005234 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 360911005235 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 360911005236 dimer interface [polypeptide binding]; other site 360911005237 active site 360911005238 metal binding site [ion binding]; metal-binding site 360911005239 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 360911005240 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 360911005241 potential catalytic triad [active] 360911005242 conserved cys residue [active] 360911005243 Protein of unknown function, DUF606; Region: DUF606; cl01273 360911005244 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 360911005245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911005246 ligand binding site [chemical binding]; other site 360911005247 Helix-turn-helix domains; Region: HTH; cl00088 360911005248 Protein of unknown function, DUF606; Region: DUF606; cl01273 360911005249 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360911005250 Domain of unknown function DUF21; Region: DUF21; pfam01595 360911005251 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360911005252 Transporter associated domain; Region: CorC_HlyC; cl08393 360911005253 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 360911005254 amidohydrolase; Region: amidohydrolases; TIGR01891 360911005255 metal binding site [ion binding]; metal-binding site 360911005256 dimer interface [polypeptide binding]; other site 360911005257 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911005258 nudix motif; other site 360911005259 LemA family; Region: LemA; cl00742 360911005260 Peptidase family M48; Region: Peptidase_M48; cl12018 360911005261 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 360911005262 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911005263 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911005264 active site turn [active] 360911005265 phosphorylation site [posttranslational modification] 360911005266 transcriptional antiterminator BglG; Provisional; Region: PRK09772 360911005267 CAT RNA binding domain; Region: CAT_RBD; cl03904 360911005268 PRD domain; Region: PRD; cl15445 360911005269 PRD domain; Region: PRD; cl15445 360911005270 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911005271 HPr interaction site; other site 360911005272 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911005273 active site 360911005274 phosphorylation site [posttranslational modification] 360911005275 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 360911005276 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005277 Walker A/P-loop; other site 360911005278 ATP binding site [chemical binding]; other site 360911005279 Q-loop/lid; other site 360911005280 ABC transporter signature motif; other site 360911005281 Walker B; other site 360911005282 D-loop; other site 360911005283 H-loop/switch region; other site 360911005284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911005285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911005286 active site 360911005287 phosphorylation site [posttranslational modification] 360911005288 intermolecular recognition site; other site 360911005289 dimerization interface [polypeptide binding]; other site 360911005290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911005291 DNA binding site [nucleotide binding] 360911005292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911005293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911005294 dimer interface [polypeptide binding]; other site 360911005295 phosphorylation site [posttranslational modification] 360911005296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005297 ATP binding site [chemical binding]; other site 360911005298 Mg2+ binding site [ion binding]; other site 360911005299 G-X-G motif; other site 360911005300 Predicted ATPase [General function prediction only]; Region: COG3910 360911005301 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005302 Walker A/P-loop; other site 360911005303 ATP binding site [chemical binding]; other site 360911005304 Q-loop/lid; other site 360911005305 ABC transporter signature motif; other site 360911005306 Walker B; other site 360911005307 D-loop; other site 360911005308 H-loop/switch region; other site 360911005309 transcriptional antiterminator BglG; Provisional; Region: PRK09772 360911005310 CAT RNA binding domain; Region: CAT_RBD; cl03904 360911005311 PRD domain; Region: PRD; cl15445 360911005312 PRD domain; Region: PRD; cl15445 360911005313 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 360911005314 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911005315 active site turn [active] 360911005316 phosphorylation site [posttranslational modification] 360911005317 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911005318 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911005319 HPr interaction site; other site 360911005320 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911005321 active site 360911005322 phosphorylation site [posttranslational modification] 360911005323 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911005324 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 360911005325 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 360911005326 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 360911005327 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 360911005328 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 360911005329 active site 360911005330 P-loop; other site 360911005331 phosphorylation site [posttranslational modification] 360911005332 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 360911005333 methionine cluster; other site 360911005334 active site 360911005335 phosphorylation site [posttranslational modification] 360911005336 metal binding site [ion binding]; metal-binding site 360911005337 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911005338 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911005339 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911005340 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911005341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911005342 DNA-binding site [nucleotide binding]; DNA binding site 360911005343 UTRA domain; Region: UTRA; cl01230 360911005344 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911005345 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 360911005346 Walker A/P-loop; other site 360911005347 ATP binding site [chemical binding]; other site 360911005348 Q-loop/lid; other site 360911005349 ABC transporter signature motif; other site 360911005350 Walker B; other site 360911005351 D-loop; other site 360911005352 H-loop/switch region; other site 360911005353 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 360911005354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005355 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 360911005356 dimer interface [polypeptide binding]; other site 360911005357 FMN binding site [chemical binding]; other site 360911005358 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 360911005359 dimer interface [polypeptide binding]; other site 360911005360 FMN binding site [chemical binding]; other site 360911005361 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911005362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911005363 putative DNA binding site [nucleotide binding]; other site 360911005364 putative Zn2+ binding site [ion binding]; other site 360911005365 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 360911005366 active site 360911005367 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 360911005368 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 360911005369 tetramer interface [polypeptide binding]; other site 360911005370 active site 360911005371 Mg2+/Mn2+ binding site [ion binding]; other site 360911005372 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 360911005373 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 360911005374 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 360911005375 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 360911005376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911005377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911005378 dimer interface [polypeptide binding]; other site 360911005379 conserved gate region; other site 360911005380 putative PBP binding loops; other site 360911005381 ABC-ATPase subunit interface; other site 360911005382 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 360911005383 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 360911005384 [4Fe-4S] binding site [ion binding]; other site 360911005385 molybdopterin cofactor binding site; other site 360911005386 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 360911005387 molybdopterin cofactor binding site; other site 360911005388 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 360911005389 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 360911005390 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 360911005391 iron-sulfur cluster [ion binding]; other site 360911005392 [2Fe-2S] cluster binding site [ion binding]; other site 360911005393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911005394 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 360911005395 ligand binding site [chemical binding]; other site 360911005396 flexible hinge region; other site 360911005397 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 360911005398 putative switch regulator; other site 360911005399 non-specific DNA interactions [nucleotide binding]; other site 360911005400 DNA binding site [nucleotide binding] 360911005401 sequence specific DNA binding site [nucleotide binding]; other site 360911005402 putative cAMP binding site [chemical binding]; other site 360911005403 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 360911005404 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 360911005405 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911005406 FeS/SAM binding site; other site 360911005407 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 360911005408 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 360911005409 MPT binding site; other site 360911005410 trimer interface [polypeptide binding]; other site 360911005411 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 360911005412 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 360911005413 GTP binding site; other site 360911005414 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 360911005415 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 360911005416 dimer interface [polypeptide binding]; other site 360911005417 putative functional site; other site 360911005418 putative MPT binding site; other site 360911005419 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 360911005420 Walker A motif; other site 360911005421 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 360911005422 MoaE homodimer interface [polypeptide binding]; other site 360911005423 MoaD interaction [polypeptide binding]; other site 360911005424 active site residues [active] 360911005425 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 360911005426 MoaE interaction surface [polypeptide binding]; other site 360911005427 MoeB interaction surface [polypeptide binding]; other site 360911005428 thiocarboxylated glycine; other site 360911005429 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 360911005430 trimer interface [polypeptide binding]; other site 360911005431 dimer interface [polypeptide binding]; other site 360911005432 putative active site [active] 360911005433 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 360911005434 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 360911005435 ATP binding site [chemical binding]; other site 360911005436 substrate interface [chemical binding]; other site 360911005437 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 360911005438 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 360911005439 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 360911005440 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911005441 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 360911005442 NodB motif; other site 360911005443 active site 360911005444 catalytic site [active] 360911005445 metal binding site [ion binding]; metal-binding site 360911005446 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911005447 putative peptidoglycan binding site; other site 360911005448 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911005449 putative peptidoglycan binding site; other site 360911005450 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 360911005451 putative peptidoglycan binding site; other site 360911005452 FixH; Region: FixH; cl01254 360911005453 FixH; Region: FixH; cl01254 360911005454 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 360911005455 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005456 Walker A/P-loop; other site 360911005457 ATP binding site [chemical binding]; other site 360911005458 Q-loop/lid; other site 360911005459 ABC transporter signature motif; other site 360911005460 Walker B; other site 360911005461 D-loop; other site 360911005462 H-loop/switch region; other site 360911005463 ABC transporter; Region: ABC_tran_2; pfam12848 360911005464 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911005465 Sugar fermentation stimulation protein; Region: SfsA; cl00647 360911005466 OsmC-like protein; Region: OsmC; cl00767 360911005467 peptidase T; Region: peptidase-T; TIGR01882 360911005468 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 360911005469 metal binding site [ion binding]; metal-binding site 360911005470 dimer interface [polypeptide binding]; other site 360911005471 LrgB-like family; Region: LrgB; cl00596 360911005472 LrgA family; Region: LrgA; cl00608 360911005473 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 360911005474 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 360911005475 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 360911005476 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 360911005477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911005478 Helix-turn-helix domains; Region: HTH; cl00088 360911005479 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 360911005480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911005481 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 360911005482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911005483 dimer interface [polypeptide binding]; other site 360911005484 conserved gate region; other site 360911005485 putative PBP binding loops; other site 360911005486 ABC-ATPase subunit interface; other site 360911005487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911005488 dimer interface [polypeptide binding]; other site 360911005489 conserved gate region; other site 360911005490 putative PBP binding loops; other site 360911005491 ABC-ATPase subunit interface; other site 360911005492 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 360911005493 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 360911005494 Walker A/P-loop; other site 360911005495 ATP binding site [chemical binding]; other site 360911005496 Q-loop/lid; other site 360911005497 ABC transporter signature motif; other site 360911005498 Walker B; other site 360911005499 D-loop; other site 360911005500 H-loop/switch region; other site 360911005501 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 360911005502 active site 360911005503 putative catalytic site [active] 360911005504 Cupin domain; Region: Cupin_2; cl09118 360911005505 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360911005506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005508 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911005509 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911005510 Ca binding site [ion binding]; other site 360911005511 active site 360911005512 catalytic site [active] 360911005513 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 360911005514 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911005515 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 360911005516 Pectate lyase; Region: Pec_lyase_C; cl01593 360911005517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 360911005518 DNA-binding site [nucleotide binding]; DNA binding site 360911005519 RNA-binding motif; other site 360911005520 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 360911005521 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 360911005522 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911005523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911005524 non-specific DNA binding site [nucleotide binding]; other site 360911005525 salt bridge; other site 360911005526 sequence-specific DNA binding site [nucleotide binding]; other site 360911005527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 360911005528 26S proteasome subunit RPN7; Region: RPN7; pfam10602 360911005529 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 360911005530 putative dimer interface [polypeptide binding]; other site 360911005531 catalytic triad [active] 360911005532 Helix-turn-helix domains; Region: HTH; cl00088 360911005533 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 360911005534 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 360911005535 putative metal binding site [ion binding]; other site 360911005536 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911005537 active site 360911005538 5'-3' exonuclease; Region: 53EXOc; smart00475 360911005539 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360911005540 active site 360911005541 metal binding site 1 [ion binding]; metal-binding site 360911005542 putative 5' ssDNA interaction site; other site 360911005543 metal binding site 3; metal-binding site 360911005544 metal binding site 2 [ion binding]; metal-binding site 360911005545 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360911005546 putative DNA binding site [nucleotide binding]; other site 360911005547 putative metal binding site [ion binding]; other site 360911005548 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360911005549 Domain of unknown function DUF21; Region: DUF21; pfam01595 360911005550 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360911005551 Transporter associated domain; Region: CorC_HlyC; cl08393 360911005552 glucose-1-dehydrogenase; Provisional; Region: PRK08936 360911005553 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 360911005554 NAD binding site [chemical binding]; other site 360911005555 homodimer interface [polypeptide binding]; other site 360911005556 active site 360911005557 CHASE3 domain; Region: CHASE3; cl05000 360911005558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911005559 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 360911005560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911005561 dimer interface [polypeptide binding]; other site 360911005562 phosphorylation site [posttranslational modification] 360911005563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005564 ATP binding site [chemical binding]; other site 360911005565 Mg2+ binding site [ion binding]; other site 360911005566 G-X-G motif; other site 360911005567 Helix-turn-helix domains; Region: HTH; cl00088 360911005568 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 360911005569 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360911005570 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360911005571 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360911005572 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 360911005573 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 360911005574 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 360911005575 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 360911005576 Cysteine-rich domain; Region: CCG; pfam02754 360911005577 Cysteine-rich domain; Region: CCG; pfam02754 360911005578 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360911005579 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911005580 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911005581 DNA binding site [nucleotide binding] 360911005582 domain linker motif; other site 360911005583 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 360911005584 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 360911005585 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 360911005586 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 360911005587 DHHA2 domain; Region: DHHA2; pfam02833 360911005588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005589 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911005590 Coenzyme A binding pocket [chemical binding]; other site 360911005591 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 360911005592 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 360911005593 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 360911005594 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 360911005595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005596 Walker A/P-loop; other site 360911005597 ATP binding site [chemical binding]; other site 360911005598 Q-loop/lid; other site 360911005599 ABC transporter signature motif; other site 360911005600 Walker B; other site 360911005601 D-loop; other site 360911005602 H-loop/switch region; other site 360911005603 Predicted membrane protein [Function unknown]; Region: COG2311 360911005604 Protein of unknown function (DUF418); Region: DUF418; cl12135 360911005605 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911005606 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911005607 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911005608 ABC transporter; Region: ABC_tran_2; pfam12848 360911005609 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911005610 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 360911005611 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911005612 NAD binding site [chemical binding]; other site 360911005613 putative active site [active] 360911005614 substrate binding site [chemical binding]; other site 360911005615 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 360911005616 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911005617 active site 360911005618 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 360911005619 xanthine permease; Region: pbuX; TIGR03173 360911005620 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 360911005621 NAD binding site [chemical binding]; other site 360911005622 active site 360911005623 RDD family; Region: RDD; cl00746 360911005624 putative uracil/xanthine transporter; Provisional; Region: PRK11412 360911005625 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 360911005626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911005627 putative substrate translocation pore; other site 360911005628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911005629 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 360911005630 putative catalytic site [active] 360911005631 putative metal binding site [ion binding]; other site 360911005632 putative phosphate binding site [ion binding]; other site 360911005633 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 360911005634 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911005635 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911005636 active site turn [active] 360911005637 phosphorylation site [posttranslational modification] 360911005638 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 360911005639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005640 Coenzyme A binding pocket [chemical binding]; other site 360911005641 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911005642 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 360911005643 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 360911005644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911005645 FeS/SAM binding site; other site 360911005646 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 360911005647 active site 360911005648 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 360911005649 Ligand Binding Site [chemical binding]; other site 360911005650 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 360911005651 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 360911005652 active site 360911005653 DNA binding site [nucleotide binding] 360911005654 intracellular protease, PfpI family; Region: PfpI; TIGR01382 360911005655 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 360911005656 proposed catalytic triad [active] 360911005657 conserved cys residue [active] 360911005658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911005659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911005660 putative substrate translocation pore; other site 360911005661 Bacitracin resistance protein BacA; Region: BacA; cl00858 360911005662 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 360911005663 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 360911005664 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 360911005665 dimer interface [polypeptide binding]; other site 360911005666 substrate binding site [chemical binding]; other site 360911005667 ATP binding site [chemical binding]; other site 360911005668 FOG: CBS domain [General function prediction only]; Region: COG0517 360911005669 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 360911005670 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911005671 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 360911005672 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 360911005673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911005674 Helix-turn-helix domains; Region: HTH; cl00088 360911005675 Helix-turn-helix domains; Region: HTH; cl00088 360911005676 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911005677 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 360911005678 ligand binding site [chemical binding]; other site 360911005679 active site 360911005680 UGI interface [polypeptide binding]; other site 360911005681 catalytic site [active] 360911005682 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 360911005683 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 360911005684 cofactor binding site; other site 360911005685 metal binding site [ion binding]; metal-binding site 360911005686 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 360911005687 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911005688 substrate binding pocket [chemical binding]; other site 360911005689 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911005690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911005691 active site 360911005692 motif I; other site 360911005693 motif II; other site 360911005694 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911005695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911005696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911005697 active site 360911005698 phosphorylation site [posttranslational modification] 360911005699 intermolecular recognition site; other site 360911005700 dimerization interface [polypeptide binding]; other site 360911005701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911005702 DNA binding site [nucleotide binding] 360911005703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911005704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911005705 dimerization interface [polypeptide binding]; other site 360911005706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911005707 dimer interface [polypeptide binding]; other site 360911005708 phosphorylation site [posttranslational modification] 360911005709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005710 ATP binding site [chemical binding]; other site 360911005711 Mg2+ binding site [ion binding]; other site 360911005712 G-X-G motif; other site 360911005713 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 360911005714 mercuric reductase; Validated; Region: PRK06370 360911005715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911005716 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911005717 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 360911005718 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 360911005719 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360911005720 ligand binding site [chemical binding]; other site 360911005721 flagellar motor protein MotA; Validated; Region: PRK08124 360911005722 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 360911005723 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 360911005724 Cation transport protein; Region: TrkH; cl10514 360911005725 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 360911005726 putative NAD(P) binding site [chemical binding]; other site 360911005727 active site 360911005728 putative substrate binding site [chemical binding]; other site 360911005729 Restriction endonuclease; Region: Mrr_cat; cl00516 360911005730 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 360911005731 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 360911005732 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 360911005733 FAD binding domain; Region: FAD_binding_4; pfam01565 360911005734 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 360911005735 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 360911005736 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 360911005737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005738 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 360911005739 Helix-turn-helix domains; Region: HTH; cl00088 360911005740 Divergent PAP2 family; Region: DUF212; cl00855 360911005741 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 360911005742 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 360911005743 active site residue [active] 360911005744 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911005745 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 360911005746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911005747 metal binding site [ion binding]; metal-binding site 360911005748 active site 360911005749 I-site; other site 360911005750 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 360911005751 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 360911005752 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 360911005753 active site 360911005754 HIGH motif; other site 360911005755 KMSK motif region; other site 360911005756 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 360911005757 tRNA binding surface [nucleotide binding]; other site 360911005758 anticodon binding site; other site 360911005759 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 360911005760 active site 360911005761 metal binding site [ion binding]; metal-binding site 360911005762 Protein of unknown function (DUF520); Region: DUF520; cl00723 360911005763 pullulanase, type I; Region: pulA_typeI; TIGR02104 360911005764 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 360911005765 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 360911005766 Ca binding site [ion binding]; other site 360911005767 active site 360911005768 catalytic site [active] 360911005769 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 360911005770 YycC-like protein; Region: YycC; pfam14174 360911005771 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 360911005772 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911005773 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911005774 YwiC-like protein; Region: YwiC; pfam14256 360911005775 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 360911005776 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 360911005777 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 360911005778 putative homodimer interface [polypeptide binding]; other site 360911005779 putative homotetramer interface [polypeptide binding]; other site 360911005780 putative metal binding site [ion binding]; other site 360911005781 putative homodimer-homodimer interface [polypeptide binding]; other site 360911005782 putative allosteric switch controlling residues; other site 360911005783 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911005784 active site residue [active] 360911005785 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 360911005786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911005787 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911005788 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 360911005789 active site residue [active] 360911005790 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 360911005791 CPxP motif; other site 360911005792 DsrE/DsrF-like family; Region: DrsE; cl00672 360911005793 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911005794 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911005795 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 360911005796 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 360911005797 intersubunit interface [polypeptide binding]; other site 360911005798 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 360911005799 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911005800 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360911005801 catalytic core [active] 360911005802 Protein of unknown function (DUF456); Region: DUF456; cl01069 360911005803 YwpF-like protein; Region: YwpF; pfam14183 360911005804 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 360911005805 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 360911005806 active site 360911005807 Isochorismatase family; Region: Isochorismatase; pfam00857 360911005808 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 360911005809 catalytic triad [active] 360911005810 conserved cis-peptide bond; other site 360911005811 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 360911005812 aromatic arch; other site 360911005813 DCoH dimer interaction site [polypeptide binding]; other site 360911005814 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 360911005815 DCoH tetramer interaction site [polypeptide binding]; other site 360911005816 substrate binding site [chemical binding]; other site 360911005817 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 360911005818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005819 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 360911005820 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 360911005821 heterotetramer interface [polypeptide binding]; other site 360911005822 active site pocket [active] 360911005823 cleavage site 360911005824 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 360911005825 nucleotide binding site [chemical binding]; other site 360911005826 N-acetyl-L-glutamate binding site [chemical binding]; other site 360911005827 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 360911005828 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911005829 inhibitor-cofactor binding pocket; inhibition site 360911005830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911005831 catalytic residue [active] 360911005832 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 360911005833 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 360911005834 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 360911005835 catalytic site [active] 360911005836 subunit interface [polypeptide binding]; other site 360911005837 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911005838 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 360911005839 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911005840 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 360911005841 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 360911005842 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911005843 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 360911005844 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911005845 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360911005846 ornithine carbamoyltransferase; Provisional; Region: PRK00779 360911005847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005848 Rhomboid family; Region: Rhomboid; cl11446 360911005849 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 360911005850 alanine racemase; Reviewed; Region: alr; PRK00053 360911005851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 360911005852 active site 360911005853 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911005854 dimer interface [polypeptide binding]; other site 360911005855 substrate binding site [chemical binding]; other site 360911005856 catalytic residues [active] 360911005857 PemK-like protein; Region: PemK; cl00995 360911005858 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 360911005859 anti sigma factor interaction site; other site 360911005860 regulatory phosphorylation site [posttranslational modification]; other site 360911005861 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 360911005862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005863 ATP binding site [chemical binding]; other site 360911005864 Mg2+ binding site [ion binding]; other site 360911005865 G-X-G motif; other site 360911005866 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 360911005867 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911005868 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360911005869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911005870 DNA binding residues [nucleotide binding] 360911005871 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 360911005872 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 360911005873 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 360911005874 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 360911005875 RNA binding site [nucleotide binding]; other site 360911005876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005877 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911005878 Coenzyme A binding pocket [chemical binding]; other site 360911005879 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 360911005880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005881 active site 360911005882 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 360911005883 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 360911005884 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 360911005885 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 360911005886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005887 Coenzyme A binding pocket [chemical binding]; other site 360911005888 UGMP family protein; Validated; Region: PRK09604 360911005889 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 360911005890 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 360911005891 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911005892 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 360911005893 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911005894 putative NAD(P) binding site [chemical binding]; other site 360911005895 substrate binding site [chemical binding]; other site 360911005896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360911005897 Helix-turn-helix domains; Region: HTH; cl00088 360911005898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 360911005899 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 360911005900 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 360911005901 dimer interface [polypeptide binding]; other site 360911005902 active site 360911005903 metal binding site [ion binding]; metal-binding site 360911005904 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 360911005905 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 360911005906 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 360911005907 potential catalytic triad [active] 360911005908 conserved cys residue [active] 360911005909 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911005910 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911005911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005912 Q-loop/lid; other site 360911005913 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911005914 ABC transporter signature motif; other site 360911005915 Walker B; other site 360911005916 D-loop; other site 360911005917 ABC transporter; Region: ABC_tran_2; pfam12848 360911005918 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911005919 peptide chain release factor 1; Validated; Region: prfA; PRK00591 360911005920 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 360911005921 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 360911005922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005923 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 360911005924 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 360911005925 Cobalt transport protein; Region: CbiQ; cl00463 360911005926 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 360911005927 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 360911005928 Walker A/P-loop; other site 360911005929 ATP binding site [chemical binding]; other site 360911005930 Q-loop/lid; other site 360911005931 ABC transporter signature motif; other site 360911005932 Walker B; other site 360911005933 D-loop; other site 360911005934 H-loop/switch region; other site 360911005935 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 360911005936 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 360911005937 Walker A/P-loop; other site 360911005938 ATP binding site [chemical binding]; other site 360911005939 Q-loop/lid; other site 360911005940 ABC transporter signature motif; other site 360911005941 Walker B; other site 360911005942 D-loop; other site 360911005943 H-loop/switch region; other site 360911005944 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 360911005945 Uncharacterized conserved protein [Function unknown]; Region: COG1912 360911005946 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 360911005947 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 360911005948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911005949 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911005950 PspC domain; Region: PspC; cl00864 360911005951 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 360911005952 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 360911005953 siderophore binding site; other site 360911005954 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 360911005955 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911005956 ABC-ATPase subunit interface; other site 360911005957 dimer interface [polypeptide binding]; other site 360911005958 putative PBP binding regions; other site 360911005959 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 360911005960 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911005961 ABC-ATPase subunit interface; other site 360911005962 dimer interface [polypeptide binding]; other site 360911005963 putative PBP binding regions; other site 360911005964 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 360911005965 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360911005966 Walker A/P-loop; other site 360911005967 ATP binding site [chemical binding]; other site 360911005968 Q-loop/lid; other site 360911005969 ABC transporter signature motif; other site 360911005970 Walker B; other site 360911005971 D-loop; other site 360911005972 H-loop/switch region; other site 360911005973 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 360911005974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005975 TM2 domain; Region: TM2; cl00984 360911005976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911005977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 360911005978 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 360911005979 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 360911005980 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 360911005981 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 360911005982 CAAX protease self-immunity; Region: Abi; cl00558 360911005983 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 360911005984 oligomerisation interface [polypeptide binding]; other site 360911005985 mobile loop; other site 360911005986 roof hairpin; other site 360911005987 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 360911005988 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 360911005989 ring oligomerisation interface [polypeptide binding]; other site 360911005990 ATP/Mg binding site [chemical binding]; other site 360911005991 stacking interactions; other site 360911005992 hinge regions; other site 360911005993 Competence protein CoiA-like family; Region: CoiA; cl11541 360911005994 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 360911005995 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 360911005996 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360911005997 active site 360911005998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911005999 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 360911006000 Uncharacterized conserved protein [Function unknown]; Region: COG3410 360911006001 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 360911006002 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 360911006003 5' RNA guide strand anchoring site; other site 360911006004 active site 360911006005 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 360911006006 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911006007 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 360911006008 Walker A/P-loop; other site 360911006009 ATP binding site [chemical binding]; other site 360911006010 Q-loop/lid; other site 360911006011 ABC transporter signature motif; other site 360911006012 Walker B; other site 360911006013 D-loop; other site 360911006014 H-loop/switch region; other site 360911006015 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 360911006016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911006017 ATP binding site [chemical binding]; other site 360911006018 Q-loop/lid; other site 360911006019 ABC transporter signature motif; other site 360911006020 Walker B; other site 360911006021 D-loop; other site 360911006022 H-loop/switch region; other site 360911006023 LytTr DNA-binding domain; Region: LytTR; cl04498 360911006024 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 360911006025 Isochorismatase family; Region: Isochorismatase; pfam00857 360911006026 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 360911006027 catalytic triad [active] 360911006028 conserved cis-peptide bond; other site 360911006029 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 360911006030 Helix-turn-helix domains; Region: HTH; cl00088 360911006031 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 360911006032 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 360911006033 active site 360911006034 NTP binding site [chemical binding]; other site 360911006035 metal binding triad [ion binding]; metal-binding site 360911006036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006037 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 360911006038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911006040 Helix-turn-helix domains; Region: HTH; cl00088 360911006041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006042 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911006043 putative substrate translocation pore; other site 360911006044 Protein of unknown function, DUF606; Region: DUF606; cl01273 360911006045 Protein of unknown function, DUF606; Region: DUF606; cl01273 360911006046 Protein of unknown function, DUF606; Region: DUF606; cl01273 360911006047 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911006048 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 360911006049 ligand binding site [chemical binding]; other site 360911006050 flexible hinge region; other site 360911006051 Helix-turn-helix domains; Region: HTH; cl00088 360911006052 Protein of unknown function, DUF606; Region: DUF606; cl01273 360911006053 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911006054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911006055 Walker A/P-loop; other site 360911006056 ATP binding site [chemical binding]; other site 360911006057 Q-loop/lid; other site 360911006058 ABC transporter signature motif; other site 360911006059 Walker B; other site 360911006060 D-loop; other site 360911006061 H-loop/switch region; other site 360911006062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006063 phytoene desaturase; Region: crtI_fam; TIGR02734 360911006064 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 360911006065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911006066 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 360911006067 Walker A/P-loop; other site 360911006068 ATP binding site [chemical binding]; other site 360911006069 Q-loop/lid; other site 360911006070 ABC transporter signature motif; other site 360911006071 Walker B; other site 360911006072 D-loop; other site 360911006073 H-loop/switch region; other site 360911006074 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360911006075 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 360911006076 FtsX-like permease family; Region: FtsX; cl15850 360911006077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911006078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006079 active site 360911006080 phosphorylation site [posttranslational modification] 360911006081 intermolecular recognition site; other site 360911006082 dimerization interface [polypeptide binding]; other site 360911006083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911006084 DNA binding site [nucleotide binding] 360911006085 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 360911006086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911006087 dimerization interface [polypeptide binding]; other site 360911006088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006089 dimer interface [polypeptide binding]; other site 360911006090 phosphorylation site [posttranslational modification] 360911006091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006092 ATP binding site [chemical binding]; other site 360911006093 Mg2+ binding site [ion binding]; other site 360911006094 G-X-G motif; other site 360911006095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911006096 Helix-turn-helix domains; Region: HTH; cl00088 360911006097 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 360911006098 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 360911006099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911006100 Walker A/P-loop; other site 360911006101 ATP binding site [chemical binding]; other site 360911006102 Q-loop/lid; other site 360911006103 ABC transporter signature motif; other site 360911006104 Walker B; other site 360911006105 D-loop; other site 360911006106 H-loop/switch region; other site 360911006107 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911006108 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911006109 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911006110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911006111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006112 active site 360911006113 phosphorylation site [posttranslational modification] 360911006114 intermolecular recognition site; other site 360911006115 dimerization interface [polypeptide binding]; other site 360911006116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911006117 DNA binding site [nucleotide binding] 360911006118 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 360911006119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911006120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911006121 dimerization interface [polypeptide binding]; other site 360911006122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006123 dimer interface [polypeptide binding]; other site 360911006124 phosphorylation site [posttranslational modification] 360911006125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006126 ATP binding site [chemical binding]; other site 360911006127 Mg2+ binding site [ion binding]; other site 360911006128 G-X-G motif; other site 360911006129 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 360911006130 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 360911006131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006132 putative substrate translocation pore; other site 360911006133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911006135 Helix-turn-helix domains; Region: HTH; cl00088 360911006136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911006137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911006138 DNA binding site [nucleotide binding] 360911006139 domain linker motif; other site 360911006140 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 360911006141 ligand binding site [chemical binding]; other site 360911006142 dimerization interface [polypeptide binding]; other site 360911006143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360911006144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911006145 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 360911006146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006147 dimer interface [polypeptide binding]; other site 360911006148 conserved gate region; other site 360911006149 putative PBP binding loops; other site 360911006150 ABC-ATPase subunit interface; other site 360911006151 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911006152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006153 dimer interface [polypeptide binding]; other site 360911006154 conserved gate region; other site 360911006155 putative PBP binding loops; other site 360911006156 ABC-ATPase subunit interface; other site 360911006157 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911006158 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911006159 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 360911006160 NADP binding site [chemical binding]; other site 360911006161 dimer interface [polypeptide binding]; other site 360911006162 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911006163 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911006164 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911006165 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 360911006166 active site 360911006167 P-loop; other site 360911006168 phosphorylation site [posttranslational modification] 360911006169 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 360911006170 active site 360911006171 methionine cluster; other site 360911006172 phosphorylation site [posttranslational modification] 360911006173 metal binding site [ion binding]; metal-binding site 360911006174 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911006175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911006176 DNA-binding site [nucleotide binding]; DNA binding site 360911006177 UTRA domain; Region: UTRA; cl01230 360911006178 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 360911006179 putative catalytic site [active] 360911006180 putative metal binding site [ion binding]; other site 360911006181 putative phosphate binding site [ion binding]; other site 360911006182 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 360911006183 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 360911006184 glutaminase active site [active] 360911006185 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 360911006186 dimer interface [polypeptide binding]; other site 360911006187 active site 360911006188 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 360911006189 dimer interface [polypeptide binding]; other site 360911006190 active site 360911006191 Helix-turn-helix domains; Region: HTH; cl00088 360911006192 Helix-turn-helix domains; Region: HTH; cl00088 360911006193 PRD domain; Region: PRD; cl15445 360911006194 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 360911006195 active site 360911006196 P-loop; other site 360911006197 phosphorylation site [posttranslational modification] 360911006198 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 360911006199 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 360911006200 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 360911006201 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 360911006202 active site 360911006203 P-loop; other site 360911006204 phosphorylation site [posttranslational modification] 360911006205 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360911006206 active site 360911006207 phosphorylation site [posttranslational modification] 360911006208 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 360911006209 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 360911006210 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 360911006211 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 360911006212 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911006213 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911006214 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006215 metal binding site [ion binding]; metal-binding site 360911006216 active site 360911006217 I-site; other site 360911006218 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006219 CAAX protease self-immunity; Region: Abi; cl00558 360911006220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911006221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006222 Coenzyme A binding pocket [chemical binding]; other site 360911006223 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006224 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006225 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006226 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006227 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 360911006228 active site 360911006229 metal binding site [ion binding]; metal-binding site 360911006230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911006231 non-specific DNA binding site [nucleotide binding]; other site 360911006232 salt bridge; other site 360911006233 sequence-specific DNA binding site [nucleotide binding]; other site 360911006234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911006235 TPR motif; other site 360911006236 binding surface 360911006237 Tetratricopeptide repeat; Region: TPR_12; pfam13424 360911006238 GAF domain; Region: GAF; cl15785 360911006239 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 360911006240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006241 dimer interface [polypeptide binding]; other site 360911006242 phosphorylation site [posttranslational modification] 360911006243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006244 ATP binding site [chemical binding]; other site 360911006245 Mg2+ binding site [ion binding]; other site 360911006246 G-X-G motif; other site 360911006247 Flavin Reductases; Region: FlaRed; cl00801 360911006248 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911006249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911006250 Walker A motif; other site 360911006251 ATP binding site [chemical binding]; other site 360911006252 Walker B motif; other site 360911006253 arginine finger; other site 360911006254 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911006255 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 360911006256 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 360911006257 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 360911006258 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 360911006259 GMP synthase; Reviewed; Region: guaA; PRK00074 360911006260 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 360911006261 AMP/PPi binding site [chemical binding]; other site 360911006262 candidate oxyanion hole; other site 360911006263 catalytic triad [active] 360911006264 potential glutamine specificity residues [chemical binding]; other site 360911006265 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 360911006266 ATP Binding subdomain [chemical binding]; other site 360911006267 Ligand Binding sites [chemical binding]; other site 360911006268 Dimerization subdomain; other site 360911006269 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360911006270 VanW like protein; Region: VanW; pfam04294 360911006271 NETI protein; Region: NETI; pfam14044 360911006272 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 360911006273 nudix motif; other site 360911006274 AIR carboxylase; Region: AIRC; cl00310 360911006275 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 360911006276 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911006277 adenylosuccinate lyase; Provisional; Region: PRK07492 360911006278 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 360911006279 tetramer interface [polypeptide binding]; other site 360911006280 active site 360911006281 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 360911006282 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 360911006283 ATP binding site [chemical binding]; other site 360911006284 active site 360911006285 substrate binding site [chemical binding]; other site 360911006286 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 360911006287 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 360911006288 putative active site [active] 360911006289 catalytic triad [active] 360911006290 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 360911006291 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 360911006292 dimerization interface [polypeptide binding]; other site 360911006293 ATP binding site [chemical binding]; other site 360911006294 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 360911006295 dimerization interface [polypeptide binding]; other site 360911006296 ATP binding site [chemical binding]; other site 360911006297 amidophosphoribosyltransferase; Provisional; Region: PRK07631 360911006298 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 360911006299 active site 360911006300 tetramer interface [polypeptide binding]; other site 360911006301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911006302 active site 360911006303 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 360911006304 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 360911006305 dimerization interface [polypeptide binding]; other site 360911006306 putative ATP binding site [chemical binding]; other site 360911006307 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 360911006308 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 360911006309 active site 360911006310 substrate binding site [chemical binding]; other site 360911006311 cosubstrate binding site; other site 360911006312 catalytic site [active] 360911006313 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 360911006314 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 360911006315 purine monophosphate binding site [chemical binding]; other site 360911006316 dimer interface [polypeptide binding]; other site 360911006317 putative catalytic residues [active] 360911006318 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 360911006319 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 360911006320 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 360911006321 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 360911006322 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911006323 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 360911006324 CHASE4 domain; Region: CHASE4; cl01308 360911006325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006326 metal binding site [ion binding]; metal-binding site 360911006327 active site 360911006328 I-site; other site 360911006329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006330 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 360911006331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911006332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911006333 active site 360911006334 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911006335 Helix-turn-helix domains; Region: HTH; cl00088 360911006336 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 360911006337 Cation transport protein; Region: TrkH; cl10514 360911006338 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 360911006339 substrate binding site [chemical binding]; other site 360911006340 putative active site [active] 360911006341 dimer interface [polypeptide binding]; other site 360911006342 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 360911006343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911006344 Family description; Region: UvrD_C_2; cl15862 360911006345 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 360911006346 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 360911006347 nucleotide binding pocket [chemical binding]; other site 360911006348 K-X-D-G motif; other site 360911006349 catalytic site [active] 360911006350 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 360911006351 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 360911006352 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 360911006353 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 360911006354 Dimer interface [polypeptide binding]; other site 360911006355 BRCT sequence motif; other site 360911006356 Fibronectin type III-like domain; Region: Fn3-like; cl15273 360911006357 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 360911006358 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 360911006359 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 360911006360 HSP70 interaction site [polypeptide binding]; other site 360911006361 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 360911006362 substrate binding site [polypeptide binding]; other site 360911006363 dimer interface [polypeptide binding]; other site 360911006364 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 360911006365 Clp amino terminal domain; Region: Clp_N; pfam02861 360911006366 Clp amino terminal domain; Region: Clp_N; pfam02861 360911006367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911006368 Walker A motif; other site 360911006369 ATP binding site [chemical binding]; other site 360911006370 Walker B motif; other site 360911006371 arginine finger; other site 360911006372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911006373 Walker A motif; other site 360911006374 ATP binding site [chemical binding]; other site 360911006375 Walker B motif; other site 360911006376 arginine finger; other site 360911006377 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 360911006378 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 360911006379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911006380 FeS/SAM binding site; other site 360911006381 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 360911006382 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 360911006383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006384 Glutaminase; Region: Glutaminase; cl00907 360911006385 CHAD domain; Region: CHAD; cl10506 360911006386 multidrug efflux protein; Reviewed; Region: PRK01766 360911006387 MatE; Region: MatE; cl10513 360911006388 MatE; Region: MatE; cl10513 360911006389 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 360911006390 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 360911006391 active site 360911006392 dimer interface [polypeptide binding]; other site 360911006393 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 360911006394 active site 360911006395 trimer interface [polypeptide binding]; other site 360911006396 allosteric site; other site 360911006397 active site lid [active] 360911006398 hexamer (dimer of trimers) interface [polypeptide binding]; other site 360911006399 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 360911006400 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911006401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911006402 DNA-binding site [nucleotide binding]; DNA binding site 360911006403 UTRA domain; Region: UTRA; cl01230 360911006404 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 360911006405 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 360911006406 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911006407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006408 Coenzyme A binding pocket [chemical binding]; other site 360911006409 aspartate kinase; Reviewed; Region: PRK06635 360911006410 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 360911006411 putative nucleotide binding site [chemical binding]; other site 360911006412 putative catalytic residues [active] 360911006413 putative Mg ion binding site [ion binding]; other site 360911006414 putative aspartate binding site [chemical binding]; other site 360911006415 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 360911006416 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 360911006417 putative allosteric regulatory residue; other site 360911006418 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 360911006419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006420 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 360911006421 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 360911006422 dihydrodipicolinate synthase; Region: dapA; TIGR00674 360911006423 dimer interface [polypeptide binding]; other site 360911006424 active site 360911006425 catalytic residue [active] 360911006426 dihydrodipicolinate reductase; Provisional; Region: PRK00048 360911006427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006428 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 360911006429 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 360911006430 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 360911006431 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 360911006432 putative trimer interface [polypeptide binding]; other site 360911006433 putative CoA binding site [chemical binding]; other site 360911006434 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 360911006435 homodimer interface [polypeptide binding]; other site 360911006436 substrate-cofactor binding pocket; other site 360911006437 catalytic residue [active] 360911006438 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 360911006439 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 360911006440 active site 360911006441 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911006442 dimer interface [polypeptide binding]; other site 360911006443 substrate binding site [chemical binding]; other site 360911006444 catalytic residues [active] 360911006445 diaminopimelate decarboxylase; Region: lysA; TIGR01048 360911006446 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 360911006447 active site 360911006448 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911006449 substrate binding site [chemical binding]; other site 360911006450 catalytic residues [active] 360911006451 dimer interface [polypeptide binding]; other site 360911006452 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 360911006453 putative FMN binding site [chemical binding]; other site 360911006454 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 360911006455 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 360911006456 trimer interface [polypeptide binding]; other site 360911006457 putative metal binding site [ion binding]; other site 360911006458 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 360911006459 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 360911006460 active site 360911006461 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911006462 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 360911006463 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911006464 peptide binding site [polypeptide binding]; other site 360911006465 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 360911006466 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 360911006467 PAS fold; Region: PAS; pfam00989 360911006468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 360911006469 PAS domain; Region: PAS_9; pfam13426 360911006470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911006471 putative active site [active] 360911006472 heme pocket [chemical binding]; other site 360911006473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006474 metal binding site [ion binding]; metal-binding site 360911006475 active site 360911006476 I-site; other site 360911006477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006478 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 360911006479 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911006480 inhibitor-cofactor binding pocket; inhibition site 360911006481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911006482 catalytic residue [active] 360911006483 CrcB-like protein; Region: CRCB; cl09114 360911006484 CrcB-like protein; Region: CRCB; cl09114 360911006485 YhfH-like protein; Region: YhfH; pfam14149 360911006486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911006487 dimerization interface [polypeptide binding]; other site 360911006488 putative DNA binding site [nucleotide binding]; other site 360911006489 putative Zn2+ binding site [ion binding]; other site 360911006490 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360911006491 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 360911006492 metal-binding site [ion binding] 360911006493 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911006494 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911006495 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 360911006496 homodimer interface [polypeptide binding]; other site 360911006497 active site 360911006498 catalytic site [active] 360911006499 maltose binding site 2 [chemical binding]; other site 360911006500 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 360911006501 PAS domain S-box; Region: sensory_box; TIGR00229 360911006502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911006503 putative active site [active] 360911006504 heme pocket [chemical binding]; other site 360911006505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006506 metal binding site [ion binding]; metal-binding site 360911006507 active site 360911006508 I-site; other site 360911006509 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006510 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911006511 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911006512 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911006513 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 360911006514 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 360911006515 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911006516 Putative esterase; Region: Esterase; pfam00756 360911006517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911006518 Helix-turn-helix domains; Region: HTH; cl00088 360911006519 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 360911006520 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 360911006521 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911006522 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911006523 Protein of unknown function (DUF554); Region: DUF554; cl00784 360911006524 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 360911006525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006526 Haemolytic domain; Region: Haemolytic; cl00506 360911006527 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911006528 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911006529 Ion channel; Region: Ion_trans_2; cl11596 360911006530 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 360911006531 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 360911006532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006533 NAD(P) binding site [chemical binding]; other site 360911006534 active site 360911006535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911006536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006537 Coenzyme A binding pocket [chemical binding]; other site 360911006538 Domain of unknown function (DUF368); Region: DUF368; cl00893 360911006539 Phospholipid methyltransferase; Region: PEMT; cl00763 360911006540 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 360911006541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006542 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911006543 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 360911006544 dimer interface [polypeptide binding]; other site 360911006545 substrate binding site [chemical binding]; other site 360911006546 metal binding site [ion binding]; metal-binding site 360911006547 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 360911006548 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 360911006549 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911006550 NAD(P) binding site [chemical binding]; other site 360911006551 putative active site [active] 360911006552 PspC domain; Region: PspC; cl00864 360911006553 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 360911006554 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 360911006555 active site 360911006556 catalytic residues [active] 360911006557 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 360911006558 catalytic residues [active] 360911006559 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 360911006560 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911006561 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006562 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006563 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006564 Bacterial SH3 domain; Region: SH3_3; cl02551 360911006565 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 360911006566 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 360911006567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911006568 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 360911006569 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 360911006570 Potassium binding sites [ion binding]; other site 360911006571 Cesium cation binding sites [ion binding]; other site 360911006572 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360911006573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006574 dimer interface [polypeptide binding]; other site 360911006575 conserved gate region; other site 360911006576 putative PBP binding loops; other site 360911006577 ABC-ATPase subunit interface; other site 360911006578 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911006579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006580 dimer interface [polypeptide binding]; other site 360911006581 conserved gate region; other site 360911006582 putative PBP binding loops; other site 360911006583 ABC-ATPase subunit interface; other site 360911006584 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 360911006585 motif 1; other site 360911006586 dimer interface [polypeptide binding]; other site 360911006587 active site 360911006588 motif 2; other site 360911006589 motif 3; other site 360911006590 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360911006591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911006592 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 360911006593 NosL; Region: NosL; cl01769 360911006594 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911006595 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 360911006596 Walker A/P-loop; other site 360911006597 ATP binding site [chemical binding]; other site 360911006598 Q-loop/lid; other site 360911006599 ABC transporter signature motif; other site 360911006600 Walker B; other site 360911006601 D-loop; other site 360911006602 H-loop/switch region; other site 360911006603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911006604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006605 putative substrate translocation pore; other site 360911006606 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 360911006607 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 360911006608 Peptidase family M48; Region: Peptidase_M48; cl12018 360911006609 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 360911006610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911006611 Histidine kinase; Region: His_kinase; pfam06580 360911006612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 360911006613 Response regulator receiver domain; Region: Response_reg; pfam00072 360911006614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006615 active site 360911006616 phosphorylation site [posttranslational modification] 360911006617 intermolecular recognition site; other site 360911006618 dimerization interface [polypeptide binding]; other site 360911006619 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360911006620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911006621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911006622 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 360911006623 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 360911006624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006625 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911006626 putative substrate translocation pore; other site 360911006627 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 360911006628 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 360911006629 NAD(P) binding site [chemical binding]; other site 360911006630 catalytic residues [active] 360911006631 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 360911006632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911006633 ligand binding site [chemical binding]; other site 360911006634 flexible hinge region; other site 360911006635 Helix-turn-helix domains; Region: HTH; cl00088 360911006636 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 360911006637 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 360911006638 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 360911006639 Low-spin heme binding site [chemical binding]; other site 360911006640 Subunit I/II interface [polypeptide binding]; other site 360911006641 Putative Q-pathway; other site 360911006642 Putative D-pathway homolog; other site 360911006643 Putative alternate electron transfer pathway; other site 360911006644 Putative water exit pathway; other site 360911006645 Binuclear center (active site) [active] 360911006646 Putative K-pathway homolog; other site 360911006647 Putative proton exit pathway; other site 360911006648 Subunit I/IIa interface [polypeptide binding]; other site 360911006649 Electron transfer pathway; other site 360911006650 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911006651 AAA domain; Region: AAA_33; pfam13671 360911006652 active site 360911006653 Predicted transcriptional regulators [Transcription]; Region: COG1725 360911006654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911006655 DNA-binding site [nucleotide binding]; DNA binding site 360911006656 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 360911006657 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 360911006658 Walker A/P-loop; other site 360911006659 ATP binding site [chemical binding]; other site 360911006660 Q-loop/lid; other site 360911006661 ABC transporter signature motif; other site 360911006662 Walker B; other site 360911006663 D-loop; other site 360911006664 H-loop/switch region; other site 360911006665 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911006666 DEAD-like helicases superfamily; Region: DEXDc; smart00487 360911006667 ATP binding site [chemical binding]; other site 360911006668 Mg++ binding site [ion binding]; other site 360911006669 motif III; other site 360911006670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911006671 nucleotide binding region [chemical binding]; other site 360911006672 ATP-binding site [chemical binding]; other site 360911006673 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 360911006674 Pyruvate formate lyase 1; Region: PFL1; cd01678 360911006675 coenzyme A binding site [chemical binding]; other site 360911006676 active site 360911006677 catalytic residues [active] 360911006678 glycine loop; other site 360911006679 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 360911006680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911006681 FeS/SAM binding site; other site 360911006682 Predicted GTPases [General function prediction only]; Region: COG1162 360911006683 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911006684 RNA binding site [nucleotide binding]; other site 360911006685 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 360911006686 GTPase/Zn-binding domain interface [polypeptide binding]; other site 360911006687 GTP/Mg2+ binding site [chemical binding]; other site 360911006688 G4 box; other site 360911006689 G5 box; other site 360911006690 G1 box; other site 360911006691 Switch I region; other site 360911006692 G2 box; other site 360911006693 G3 box; other site 360911006694 Switch II region; other site 360911006695 Predicted membrane protein [Function unknown]; Region: COG4758 360911006696 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 360911006697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 360911006698 Histidine kinase; Region: HisKA_3; pfam07730 360911006699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006700 ATP binding site [chemical binding]; other site 360911006701 Mg2+ binding site [ion binding]; other site 360911006702 G-X-G motif; other site 360911006703 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 360911006704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006705 active site 360911006706 phosphorylation site [posttranslational modification] 360911006707 intermolecular recognition site; other site 360911006708 dimerization interface [polypeptide binding]; other site 360911006709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360911006710 DNA binding residues [nucleotide binding] 360911006711 dimerization interface [polypeptide binding]; other site 360911006712 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911006713 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911006714 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911006715 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 360911006716 putative NAD(P) binding site [chemical binding]; other site 360911006717 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911006718 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911006719 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911006720 ABC transporter; Region: ABC_tran_2; pfam12848 360911006721 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911006722 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 360911006723 putative acyl-acceptor binding pocket; other site 360911006724 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 360911006725 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911006726 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911006727 DEAD-like helicases superfamily; Region: DEXDc; smart00487 360911006728 ATP binding site [chemical binding]; other site 360911006729 Mg++ binding site [ion binding]; other site 360911006730 motif III; other site 360911006731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911006732 nucleotide binding region [chemical binding]; other site 360911006733 ATP-binding site [chemical binding]; other site 360911006734 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 360911006735 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 360911006736 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 360911006737 active site 360911006738 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 360911006739 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 360911006740 metal binding site [ion binding]; metal-binding site 360911006741 substrate binding pocket [chemical binding]; other site 360911006742 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 360911006743 AMP-binding enzyme; Region: AMP-binding; cl15778 360911006744 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360911006745 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 360911006746 substrate binding site [chemical binding]; other site 360911006747 oxyanion hole (OAH) forming residues; other site 360911006748 trimer interface [polypeptide binding]; other site 360911006749 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 360911006750 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911006751 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 360911006752 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 360911006753 dimer interface [polypeptide binding]; other site 360911006754 tetramer interface [polypeptide binding]; other site 360911006755 PYR/PP interface [polypeptide binding]; other site 360911006756 TPP binding site [chemical binding]; other site 360911006757 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 360911006758 TPP-binding site; other site 360911006759 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 360911006760 chorismate binding enzyme; Region: Chorismate_bind; cl10555 360911006761 UbiA prenyltransferase family; Region: UbiA; cl00337 360911006762 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 360911006763 active site clefts [active] 360911006764 zinc binding site [ion binding]; other site 360911006765 dimer interface [polypeptide binding]; other site 360911006766 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 360911006767 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911006768 nudix motif; other site 360911006769 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 360911006770 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360911006771 substrate binding site [chemical binding]; other site 360911006772 ATP binding site [chemical binding]; other site 360911006773 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 360911006774 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911006775 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911006776 EamA-like transporter family; Region: EamA; cl01037 360911006777 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 360911006778 EamA-like transporter family; Region: EamA; cl01037 360911006779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006780 putative substrate translocation pore; other site 360911006781 Radical SAM superfamily; Region: Radical_SAM; pfam04055 360911006782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911006783 FeS/SAM binding site; other site 360911006784 YfkB-like domain; Region: YfkB; pfam08756 360911006785 TRAM domain; Region: TRAM; cl01282 360911006786 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 360911006787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911006788 S-adenosylmethionine binding site [chemical binding]; other site 360911006789 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 360911006790 active site 360911006791 catalytic motif [active] 360911006792 Zn binding site [ion binding]; other site 360911006793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911006794 dimerization interface [polypeptide binding]; other site 360911006795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006796 dimer interface [polypeptide binding]; other site 360911006797 phosphorylation site [posttranslational modification] 360911006798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006799 ATP binding site [chemical binding]; other site 360911006800 Mg2+ binding site [ion binding]; other site 360911006801 G-X-G motif; other site 360911006802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911006803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006804 active site 360911006805 phosphorylation site [posttranslational modification] 360911006806 intermolecular recognition site; other site 360911006807 dimerization interface [polypeptide binding]; other site 360911006808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911006809 DNA binding site [nucleotide binding] 360911006810 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911006811 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911006812 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 360911006813 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 360911006814 active site 360911006815 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 360911006816 TIGR01777 family protein; Region: yfcH 360911006817 putative NAD(P) binding site [chemical binding]; other site 360911006818 putative active site [active] 360911006819 RecX family; Region: RecX; cl00936 360911006820 L-lactate permease; Region: Lactate_perm; cl00701 360911006821 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911006822 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 360911006823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911006824 Walker A/P-loop; other site 360911006825 ATP binding site [chemical binding]; other site 360911006826 Q-loop/lid; other site 360911006827 ABC transporter signature motif; other site 360911006828 Walker B; other site 360911006829 D-loop; other site 360911006830 H-loop/switch region; other site 360911006831 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911006832 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 360911006833 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911006834 Walker A/P-loop; other site 360911006835 ATP binding site [chemical binding]; other site 360911006836 Q-loop/lid; other site 360911006837 ABC transporter signature motif; other site 360911006838 Walker B; other site 360911006839 D-loop; other site 360911006840 H-loop/switch region; other site 360911006841 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 360911006842 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 360911006843 WVELL protein; Region: WVELL; pfam14043 360911006844 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 360911006845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911006846 non-specific DNA binding site [nucleotide binding]; other site 360911006847 salt bridge; other site 360911006848 sequence-specific DNA binding site [nucleotide binding]; other site 360911006849 Cupin domain; Region: Cupin_2; cl09118 360911006850 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 360911006851 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 360911006852 Walker A/P-loop; other site 360911006853 ATP binding site [chemical binding]; other site 360911006854 Q-loop/lid; other site 360911006855 ABC transporter signature motif; other site 360911006856 Walker B; other site 360911006857 D-loop; other site 360911006858 H-loop/switch region; other site 360911006859 TOBE domain; Region: TOBE_2; cl01440 360911006860 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 360911006861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006862 dimer interface [polypeptide binding]; other site 360911006863 conserved gate region; other site 360911006864 putative PBP binding loops; other site 360911006865 ABC-ATPase subunit interface; other site 360911006866 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360911006867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 360911006868 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 360911006869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911006870 Restriction endonuclease; Region: Mrr_cat; cl00516 360911006871 Protein of unknown function (DUF779); Region: DUF779; cl01432 360911006872 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 360911006873 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 360911006874 NAD(P) binding site [chemical binding]; other site 360911006875 catalytic residues [active] 360911006876 YceI-like domain; Region: YceI; cl01001 360911006877 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 360911006878 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 360911006879 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360911006880 minor groove reading motif; other site 360911006881 helix-hairpin-helix signature motif; other site 360911006882 substrate binding pocket [chemical binding]; other site 360911006883 active site 360911006884 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 360911006885 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 360911006886 DNA binding and oxoG recognition site [nucleotide binding] 360911006887 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 360911006888 hydrophobic ligand binding site; other site 360911006889 Protein of unknown function (DUF402); Region: DUF402; cl00979 360911006890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911006891 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911006892 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 360911006893 Walker A/P-loop; other site 360911006894 ATP binding site [chemical binding]; other site 360911006895 Q-loop/lid; other site 360911006896 ABC transporter signature motif; other site 360911006897 Walker B; other site 360911006898 D-loop; other site 360911006899 H-loop/switch region; other site 360911006900 Protein of unknown function, DUF393; Region: DUF393; cl01136 360911006901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911006902 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 360911006903 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911006904 inhibitor-cofactor binding pocket; inhibition site 360911006905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911006906 catalytic residue [active] 360911006907 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360911006908 metal binding site 2 [ion binding]; metal-binding site 360911006909 putative DNA binding helix; other site 360911006910 metal binding site 1 [ion binding]; metal-binding site 360911006911 dimer interface [polypeptide binding]; other site 360911006912 structural Zn2+ binding site [ion binding]; other site 360911006913 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 360911006914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911006915 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 360911006916 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 360911006917 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 360911006918 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 360911006919 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 360911006920 DNA binding site [nucleotide binding] 360911006921 active site 360911006922 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 360911006923 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 360911006924 Transglycosylase; Region: Transgly; cl07896 360911006925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911006926 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 360911006927 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 360911006928 ligand binding site; other site 360911006929 oligomer interface; other site 360911006930 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 360911006931 dimer interface [polypeptide binding]; other site 360911006932 N-terminal domain interface [polypeptide binding]; other site 360911006933 sulfate 1 binding site; other site 360911006934 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 360911006935 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 360911006936 ligand binding site; other site 360911006937 oligomer interface; other site 360911006938 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 360911006939 dimer interface [polypeptide binding]; other site 360911006940 N-terminal domain interface [polypeptide binding]; other site 360911006941 sulfate 1 binding site; other site 360911006942 glycogen synthase; Provisional; Region: glgA; PRK00654 360911006943 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 360911006944 ADP-binding pocket [chemical binding]; other site 360911006945 homodimer interface [polypeptide binding]; other site 360911006946 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 360911006947 homodimer interface [polypeptide binding]; other site 360911006948 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 360911006949 active site pocket [active] 360911006950 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 360911006951 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 360911006952 active site residue [active] 360911006953 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 360911006954 active site residue [active] 360911006955 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 360911006956 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 360911006957 active site 360911006958 substrate binding site [chemical binding]; other site 360911006959 metal binding site [ion binding]; metal-binding site 360911006960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911006961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911006962 substrate binding pocket [chemical binding]; other site 360911006963 membrane-bound complex binding site; other site 360911006964 hinge residues; other site 360911006965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006966 dimer interface [polypeptide binding]; other site 360911006967 conserved gate region; other site 360911006968 putative PBP binding loops; other site 360911006969 ABC-ATPase subunit interface; other site 360911006970 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360911006971 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 360911006972 Walker A/P-loop; other site 360911006973 ATP binding site [chemical binding]; other site 360911006974 Q-loop/lid; other site 360911006975 ABC transporter signature motif; other site 360911006976 Walker B; other site 360911006977 D-loop; other site 360911006978 H-loop/switch region; other site 360911006979 TOBE domain; Region: TOBE_2; cl01440 360911006980 Helix-turn-helix domains; Region: HTH; cl00088 360911006981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 360911006982 Protein of unknown function (DUF964); Region: DUF964; cl01483 360911006983 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 360911006984 transmembrane helices; other site 360911006985 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 360911006986 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 360911006987 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 360911006988 YhzD-like protein; Region: YhzD; pfam14120 360911006989 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 360911006990 active site 360911006991 DNA polymerase IV; Validated; Region: PRK02406 360911006992 DNA binding site [nucleotide binding] 360911006993 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 360911006994 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 360911006995 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 360911006996 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 360911006997 generic binding surface II; other site 360911006998 generic binding surface I; other site 360911006999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911007000 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 360911007001 PPIC-type PPIASE domain; Region: Rotamase; cl08278 360911007002 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 360911007003 transcriptional regulator Hpr; Provisional; Region: PRK13777 360911007004 Helix-turn-helix domains; Region: HTH; cl00088 360911007005 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 360911007006 HIT family signature motif; other site 360911007007 catalytic residue [active] 360911007008 Predicted membrane protein [Function unknown]; Region: COG4640 360911007009 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 360911007010 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 360911007011 Walker A/P-loop; other site 360911007012 ATP binding site [chemical binding]; other site 360911007013 Q-loop/lid; other site 360911007014 ABC transporter signature motif; other site 360911007015 Walker B; other site 360911007016 D-loop; other site 360911007017 H-loop/switch region; other site 360911007018 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 360911007019 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 360911007020 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 360911007021 DNA binding residues [nucleotide binding] 360911007022 putative dimer interface [polypeptide binding]; other site 360911007023 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 360911007024 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 360911007025 substrate binding site [chemical binding]; other site 360911007026 active site 360911007027 ferrochelatase; Provisional; Region: PRK12435 360911007028 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 360911007029 C-terminal domain interface [polypeptide binding]; other site 360911007030 active site 360911007031 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 360911007032 active site 360911007033 N-terminal domain interface [polypeptide binding]; other site 360911007034 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 360911007035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007037 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911007038 active site 360911007039 motif I; other site 360911007040 motif II; other site 360911007041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007042 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 360911007043 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 360911007044 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 360911007045 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 360911007046 AMP-binding enzyme; Region: AMP-binding; cl15778 360911007047 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911007048 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 360911007049 putative homodimer interface [polypeptide binding]; other site 360911007050 putative homotetramer interface [polypeptide binding]; other site 360911007051 putative allosteric switch controlling residues; other site 360911007052 putative metal binding site [ion binding]; other site 360911007053 putative homodimer-homodimer interface [polypeptide binding]; other site 360911007054 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 360911007055 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360911007056 metal-binding site [ion binding] 360911007057 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911007058 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 360911007059 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360911007060 metal-binding site [ion binding] 360911007061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911007062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911007063 active site 360911007064 phosphorylation site [posttranslational modification] 360911007065 intermolecular recognition site; other site 360911007066 dimerization interface [polypeptide binding]; other site 360911007067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911007068 DNA binding site [nucleotide binding] 360911007069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911007070 dimerization interface [polypeptide binding]; other site 360911007071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911007072 dimer interface [polypeptide binding]; other site 360911007073 phosphorylation site [posttranslational modification] 360911007074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911007075 ATP binding site [chemical binding]; other site 360911007076 Mg2+ binding site [ion binding]; other site 360911007077 G-X-G motif; other site 360911007078 ComK protein; Region: ComK; cl11560 360911007079 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 360911007080 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 360911007081 apolar tunnel; other site 360911007082 heme binding site [chemical binding]; other site 360911007083 dimerization interface [polypeptide binding]; other site 360911007084 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 360911007085 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 360911007086 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 360911007087 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007088 Family description; Region: UvrD_C_2; cl15862 360911007089 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 360911007090 Helix-turn-helix domains; Region: HTH; cl00088 360911007091 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911007092 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911007093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007094 Walker A/P-loop; other site 360911007095 ATP binding site [chemical binding]; other site 360911007096 Q-loop/lid; other site 360911007097 ABC transporter signature motif; other site 360911007098 Walker B; other site 360911007099 D-loop; other site 360911007100 H-loop/switch region; other site 360911007101 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911007102 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911007103 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 360911007104 Walker A/P-loop; other site 360911007105 ATP binding site [chemical binding]; other site 360911007106 Q-loop/lid; other site 360911007107 ABC transporter signature motif; other site 360911007108 Walker B; other site 360911007109 D-loop; other site 360911007110 H-loop/switch region; other site 360911007111 Response regulator receiver domain; Region: Response_reg; pfam00072 360911007112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911007113 active site 360911007114 phosphorylation site [posttranslational modification] 360911007115 intermolecular recognition site; other site 360911007116 dimerization interface [polypeptide binding]; other site 360911007117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911007118 GAF domain; Region: GAF; cl15785 360911007119 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 360911007120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911007121 dimer interface [polypeptide binding]; other site 360911007122 phosphorylation site [posttranslational modification] 360911007123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911007124 ATP binding site [chemical binding]; other site 360911007125 Mg2+ binding site [ion binding]; other site 360911007126 G-X-G motif; other site 360911007127 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 360911007128 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 360911007129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911007130 S-adenosylmethionine binding site [chemical binding]; other site 360911007131 phytoene desaturase; Region: crtI_fam; TIGR02734 360911007132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007133 phytoene desaturase; Region: crtI_fam; TIGR02734 360911007134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007135 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 360911007136 active site lid residues [active] 360911007137 substrate binding pocket [chemical binding]; other site 360911007138 catalytic residues [active] 360911007139 substrate-Mg2+ binding site; other site 360911007140 aspartate-rich region 1; other site 360911007141 aspartate-rich region 2; other site 360911007142 phytoene desaturase; Region: crtI_fam; TIGR02734 360911007143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007144 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 360911007145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911007146 active site 360911007147 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 360911007148 putative acyl-acceptor binding pocket; other site 360911007149 Protein of unknown function (DUF422); Region: DUF422; cl00991 360911007150 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 360911007151 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 360911007152 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 360911007153 putative deacylase active site [active] 360911007154 enoyl-CoA hydratase; Provisional; Region: PRK08140 360911007155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360911007156 substrate binding site [chemical binding]; other site 360911007157 oxyanion hole (OAH) forming residues; other site 360911007158 trimer interface [polypeptide binding]; other site 360911007159 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 360911007160 MatE; Region: MatE; cl10513 360911007161 MatE; Region: MatE; cl10513 360911007162 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 360911007163 homodimer interface [polypeptide binding]; other site 360911007164 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 360911007165 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 360911007166 active site 360911007167 homodimer interface [polypeptide binding]; other site 360911007168 catalytic site [active] 360911007169 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 360911007170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360911007171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007172 dimer interface [polypeptide binding]; other site 360911007173 conserved gate region; other site 360911007174 ABC-ATPase subunit interface; other site 360911007175 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 360911007176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007177 dimer interface [polypeptide binding]; other site 360911007178 conserved gate region; other site 360911007179 putative PBP binding loops; other site 360911007180 ABC-ATPase subunit interface; other site 360911007181 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 360911007182 trehalose synthase; Region: treS_nterm; TIGR02456 360911007183 active site 360911007184 catalytic site [active] 360911007185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911007186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911007187 DNA binding site [nucleotide binding] 360911007188 domain linker motif; other site 360911007189 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 360911007190 putative dimerization interface [polypeptide binding]; other site 360911007191 putative ligand binding site [chemical binding]; other site 360911007192 Heat induced stress protein YflT; Region: YflT; pfam11181 360911007193 maltose phosphorylase; Provisional; Region: PRK13807 360911007194 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 360911007195 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 360911007196 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 360911007197 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911007198 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911007199 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911007200 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911007201 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007202 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911007203 active site 360911007204 motif I; other site 360911007205 motif II; other site 360911007206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007207 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 360911007208 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911007209 catalytic residues [active] 360911007210 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 360911007211 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 360911007212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007213 active site 360911007214 motif I; other site 360911007215 motif II; other site 360911007216 GTPase YqeH; Provisional; Region: PRK13796 360911007217 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 360911007218 GTP/Mg2+ binding site [chemical binding]; other site 360911007219 G4 box; other site 360911007220 G5 box; other site 360911007221 G1 box; other site 360911007222 Switch I region; other site 360911007223 G2 box; other site 360911007224 G3 box; other site 360911007225 Switch II region; other site 360911007226 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 360911007227 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 360911007228 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 360911007229 shikimate binding site; other site 360911007230 NAD(P) binding site [chemical binding]; other site 360911007231 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 360911007232 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 360911007233 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 360911007234 active site 360911007235 (T/H)XGH motif; other site 360911007236 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 360911007237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911007238 Zn2+ binding site [ion binding]; other site 360911007239 Mg2+ binding site [ion binding]; other site 360911007240 Oligomerisation domain; Region: Oligomerisation; cl00519 360911007241 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 360911007242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911007243 S-adenosylmethionine binding site [chemical binding]; other site 360911007244 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 360911007245 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911007246 dimer interface [polypeptide binding]; other site 360911007247 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 360911007248 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 360911007249 tetramer interface [polypeptide binding]; other site 360911007250 heme binding pocket [chemical binding]; other site 360911007251 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 360911007252 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 360911007253 dimer interface [polypeptide binding]; other site 360911007254 FMN binding site [chemical binding]; other site 360911007255 NADPH bind site [chemical binding]; other site 360911007256 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 360911007257 catalytic residues [active] 360911007258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911007259 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 360911007260 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007262 active site residue [active] 360911007263 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007264 active site residue [active] 360911007265 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007266 active site residue [active] 360911007267 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 360911007268 Isochorismatase family; Region: Isochorismatase; pfam00857 360911007269 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 360911007270 catalytic triad [active] 360911007271 conserved cis-peptide bond; other site 360911007272 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911007273 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 360911007274 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911007275 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 360911007276 Walker A/P-loop; other site 360911007277 ATP binding site [chemical binding]; other site 360911007278 Q-loop/lid; other site 360911007279 ABC transporter signature motif; other site 360911007280 Walker B; other site 360911007281 D-loop; other site 360911007282 H-loop/switch region; other site 360911007283 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 360911007284 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 360911007285 TPP-binding site [chemical binding]; other site 360911007286 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 360911007287 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 360911007288 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360911007289 E3 interaction surface; other site 360911007290 lipoyl attachment site [posttranslational modification]; other site 360911007291 e3 binding domain; Region: E3_binding; pfam02817 360911007292 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 360911007293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911007294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911007295 metal binding site [ion binding]; metal-binding site 360911007296 active site 360911007297 I-site; other site 360911007298 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 360911007299 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 360911007300 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 360911007301 Cu(I) binding site [ion binding]; other site 360911007302 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911007303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911007304 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911007305 putative substrate translocation pore; other site 360911007306 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 360911007307 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 360911007308 catalytic residues [active] 360911007309 Haemolysin-III related; Region: HlyIII; cl03831 360911007310 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 360911007311 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 360911007312 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 360911007313 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911007314 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911007315 active site 360911007316 catalytic tetrad [active] 360911007317 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911007318 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911007319 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911007320 ABC transporter; Region: ABC_tran_2; pfam12848 360911007321 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 360911007322 Cation efflux family; Region: Cation_efflux; cl00316 360911007323 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 360911007324 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911007325 putative active site [active] 360911007326 putative metal binding site [ion binding]; other site 360911007327 OsmC-like protein; Region: OsmC; cl00767 360911007328 Helix-turn-helix domains; Region: HTH; cl00088 360911007329 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 360911007330 Uncharacterized conserved protein [Function unknown]; Region: COG3391 360911007331 NHL repeat; Region: NHL; pfam01436 360911007332 NHL repeat; Region: NHL; pfam01436 360911007333 NHL repeat; Region: NHL; pfam01436 360911007334 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 360911007335 catalytic residues [active] 360911007336 dimer interface [polypeptide binding]; other site 360911007337 VanZ like family; Region: VanZ; cl01971 360911007338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 360911007339 Arabidopsis phospholipase-like protein (PEARLI 4); Region: PEARLI-4; pfam05278 360911007340 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911007341 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911007342 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 360911007343 Cell division protein ZapA; Region: ZapA; cl01146 360911007344 Colicin V production protein; Region: Colicin_V; cl00567 360911007345 hypothetical protein; Provisional; Region: PRK08609 360911007346 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 360911007347 active site 360911007348 primer binding site [nucleotide binding]; other site 360911007349 NTP binding site [chemical binding]; other site 360911007350 metal binding triad [ion binding]; metal-binding site 360911007351 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 360911007352 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 360911007353 Walker A/P-loop; other site 360911007354 ATP binding site [chemical binding]; other site 360911007355 Q-loop/lid; other site 360911007356 ABC transporter signature motif; other site 360911007357 Walker B; other site 360911007358 D-loop; other site 360911007359 H-loop/switch region; other site 360911007360 Smr domain; Region: Smr; cl02619 360911007361 Predicted membrane protein [Function unknown]; Region: COG3766 360911007362 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 360911007363 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 360911007364 AAA domain; Region: AAA_13; pfam13166 360911007365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360911007366 FtsX-like permease family; Region: FtsX; cl15850 360911007367 FtsX-like permease family; Region: FtsX; cl15850 360911007368 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 360911007369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911007370 Walker A/P-loop; other site 360911007371 ATP binding site [chemical binding]; other site 360911007372 Q-loop/lid; other site 360911007373 ABC transporter signature motif; other site 360911007374 Walker B; other site 360911007375 D-loop; other site 360911007376 H-loop/switch region; other site 360911007377 Uncharacterized conserved protein [Function unknown]; Region: COG4997 360911007378 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 360911007379 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 360911007380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007381 Walker A/P-loop; other site 360911007382 ATP binding site [chemical binding]; other site 360911007383 Q-loop/lid; other site 360911007384 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 360911007385 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 360911007386 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007387 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007388 putative Mg++ binding site [ion binding]; other site 360911007389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911007390 nucleotide binding region [chemical binding]; other site 360911007391 ATP-binding site [chemical binding]; other site 360911007392 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 360911007393 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 360911007394 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 360911007395 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 360911007396 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911007397 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911007398 catalytic residue [active] 360911007399 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 360911007400 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 360911007401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007402 Walker A/P-loop; other site 360911007403 ATP binding site [chemical binding]; other site 360911007404 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 360911007405 Active Sites [active] 360911007406 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 360911007407 DNA-sulfur modification-associated; Region: DndB; cl14002 360911007408 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 360911007409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007410 Walker A/P-loop; other site 360911007411 ATP binding site [chemical binding]; other site 360911007412 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 360911007413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 360911007414 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 360911007415 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 360911007416 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 360911007417 dimer interface [polypeptide binding]; other site 360911007418 FMN binding site [chemical binding]; other site 360911007419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911007420 Helix-turn-helix domains; Region: HTH; cl00088 360911007421 Predicted transcriptional regulators [Transcription]; Region: COG1725 360911007422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911007423 DNA-binding site [nucleotide binding]; DNA binding site 360911007424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911007425 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 360911007426 Walker A/P-loop; other site 360911007427 ATP binding site [chemical binding]; other site 360911007428 Q-loop/lid; other site 360911007429 ABC transporter signature motif; other site 360911007430 Walker B; other site 360911007431 D-loop; other site 360911007432 H-loop/switch region; other site 360911007433 ABC-2 type transporter; Region: ABC2_membrane; cl11417 360911007434 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 360911007435 AMP-binding enzyme; Region: AMP-binding; cl15778 360911007436 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911007437 Helix-turn-helix domains; Region: HTH; cl00088 360911007438 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 360911007439 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 360911007440 Ligand binding site [chemical binding]; other site 360911007441 Electron transfer flavoprotein domain; Region: ETF; pfam01012 360911007442 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 360911007443 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 360911007444 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 360911007445 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911007446 catalytic residues [active] 360911007447 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 360911007448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 360911007449 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 360911007450 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 360911007451 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 360911007452 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 360911007453 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 360911007454 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 360911007455 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 360911007456 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 360911007457 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 360911007458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911007459 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911007460 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 360911007461 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 360911007462 GIY-YIG motif/motif A; other site 360911007463 active site 360911007464 catalytic site [active] 360911007465 putative DNA binding site [nucleotide binding]; other site 360911007466 metal binding site [ion binding]; metal-binding site 360911007467 UvrB/uvrC motif; Region: UVR; pfam02151 360911007468 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 360911007469 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 360911007470 aminoglycoside resistance protein; Provisional; Region: PRK13746 360911007471 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 360911007472 active site 360911007473 NTP binding site [chemical binding]; other site 360911007474 metal binding triad [ion binding]; metal-binding site 360911007475 antibiotic binding site [chemical binding]; other site 360911007476 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 360911007477 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 360911007478 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 360911007479 putative Iron-sulfur protein interface [polypeptide binding]; other site 360911007480 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 360911007481 proximal heme binding site [chemical binding]; other site 360911007482 distal heme binding site [chemical binding]; other site 360911007483 putative dimer interface [polypeptide binding]; other site 360911007484 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 360911007485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007486 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 360911007487 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 360911007488 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 360911007489 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360911007490 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 360911007491 active site 360911007492 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 360911007493 dimerization domain swap beta strand [polypeptide binding]; other site 360911007494 regulatory protein interface [polypeptide binding]; other site 360911007495 active site 360911007496 regulatory phosphorylation site [posttranslational modification]; other site 360911007497 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 360911007498 ribonuclease PH; Reviewed; Region: rph; PRK00173 360911007499 Ribonuclease PH; Region: RNase_PH_bact; cd11362 360911007500 hexamer interface [polypeptide binding]; other site 360911007501 active site 360911007502 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 360911007503 active site 360911007504 dimerization interface [polypeptide binding]; other site 360911007505 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 360911007506 active site 360911007507 metal binding site [ion binding]; metal-binding site 360911007508 homotetramer interface [polypeptide binding]; other site 360911007509 trigger factor; Provisional; Region: tig; PRK01490 360911007510 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 360911007511 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 360911007512 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 360911007513 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 360911007514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911007515 Walker A motif; other site 360911007516 ATP binding site [chemical binding]; other site 360911007517 Walker B motif; other site 360911007518 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 360911007519 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 360911007520 Found in ATP-dependent protease La (LON); Region: LON; smart00464 360911007521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911007522 Walker A motif; other site 360911007523 ATP binding site [chemical binding]; other site 360911007524 Walker B motif; other site 360911007525 arginine finger; other site 360911007526 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 360911007527 Predicted GTPase [General function prediction only]; Region: COG0218 360911007528 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 360911007529 G1 box; other site 360911007530 GTP/Mg2+ binding site [chemical binding]; other site 360911007531 Switch I region; other site 360911007532 G2 box; other site 360911007533 G3 box; other site 360911007534 Switch II region; other site 360911007535 G4 box; other site 360911007536 G5 box; other site 360911007537 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360911007538 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 360911007539 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 360911007540 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 360911007541 tRNA; other site 360911007542 putative tRNA binding site [nucleotide binding]; other site 360911007543 putative NADP binding site [chemical binding]; other site 360911007544 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 360911007545 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 360911007546 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 360911007547 domain interfaces; other site 360911007548 active site 360911007549 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 360911007550 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 360911007551 active site 360911007552 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 360911007553 dimer interface [polypeptide binding]; other site 360911007554 active site 360911007555 Schiff base residues; other site 360911007556 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 360911007557 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911007558 inhibitor-cofactor binding pocket; inhibition site 360911007559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911007560 catalytic residue [active] 360911007561 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 360911007562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360911007563 active site 360911007564 HIGH motif; other site 360911007565 nucleotide binding site [chemical binding]; other site 360911007566 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 360911007567 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 360911007568 active site 360911007569 KMSKS motif; other site 360911007570 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 360911007571 tRNA binding surface [nucleotide binding]; other site 360911007572 anticodon binding site; other site 360911007573 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 360911007574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911007575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911007576 Coenzyme A binding pocket [chemical binding]; other site 360911007577 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 360911007578 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 360911007579 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 360911007580 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 360911007581 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911007582 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 360911007583 VanW like protein; Region: VanW; pfam04294 360911007584 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 360911007585 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 360911007586 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 360911007587 Walker A motif; other site 360911007588 ATP binding site [chemical binding]; other site 360911007589 Walker B motif; other site 360911007590 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 360911007591 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007592 Walker A motif; other site 360911007593 ATP binding site [chemical binding]; other site 360911007594 Walker B motif; other site 360911007595 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 360911007596 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 360911007597 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 360911007598 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 360911007599 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 360911007600 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 360911007601 Competence protein A; Region: Competence_A; pfam11104 360911007602 Maf-like protein; Region: Maf; pfam02545 360911007603 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 360911007604 active site 360911007605 dimer interface [polypeptide binding]; other site 360911007606 DNA repair protein radc; Region: radc; TIGR00608 360911007607 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 360911007608 MPN+ (JAMM) motif; other site 360911007609 Zinc-binding site [ion binding]; other site 360911007610 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 360911007611 rod shape-determining protein MreB; Provisional; Region: PRK13927 360911007612 Cell division protein FtsA; Region: FtsA; cl11496 360911007613 rod shape-determining protein MreC; Provisional; Region: PRK13922 360911007614 rod shape-determining protein MreC; Region: MreC; pfam04085 360911007615 rod shape-determining protein MreD; Region: MreD; cl01087 360911007616 septum formation inhibitor; Reviewed; Region: minC; PRK00513 360911007617 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 360911007618 septum site-determining protein MinD; Region: minD_bact; TIGR01968 360911007619 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 360911007620 Switch I; other site 360911007621 Switch II; other site 360911007622 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 360911007623 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911007624 RNA binding site [nucleotide binding]; other site 360911007625 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 360911007626 Protein of unknown function (DUF464); Region: DUF464; cl01080 360911007627 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 360911007628 GTPase CgtA; Reviewed; Region: obgE; PRK12297 360911007629 GTP1/OBG; Region: GTP1_OBG; pfam01018 360911007630 Obg GTPase; Region: Obg; cd01898 360911007631 G1 box; other site 360911007632 GTP/Mg2+ binding site [chemical binding]; other site 360911007633 Switch I region; other site 360911007634 G2 box; other site 360911007635 G3 box; other site 360911007636 Switch II region; other site 360911007637 G4 box; other site 360911007638 G5 box; other site 360911007639 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 360911007640 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360911007641 Domain of unknown function DUF21; Region: DUF21; pfam01595 360911007642 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360911007643 Transporter associated domain; Region: CorC_HlyC; cl08393 360911007644 NIPSNAP; Region: NIPSNAP; pfam07978 360911007645 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911007646 nudix motif; other site 360911007647 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911007648 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 360911007649 Helix-turn-helix domains; Region: HTH; cl00088 360911007650 3H domain; Region: 3H; pfam02829 360911007651 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911007652 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 360911007653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911007654 catalytic residue [active] 360911007655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007656 L-aspartate oxidase; Region: nadB; TIGR00551 360911007657 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 360911007658 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 360911007659 dimerization interface [polypeptide binding]; other site 360911007660 active site 360911007661 Quinolinate synthetase A protein; Region: NadA; cl00420 360911007662 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 360911007663 RuvA N terminal domain; Region: RuvA_N; pfam01330 360911007664 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 360911007665 DNA binding site [nucleotide binding] 360911007666 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 360911007667 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 360911007668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911007669 Walker A motif; other site 360911007670 ATP binding site [chemical binding]; other site 360911007671 Walker B motif; other site 360911007672 arginine finger; other site 360911007673 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 360911007674 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 360911007675 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 360911007676 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 360911007677 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 360911007678 Preprotein translocase subunit; Region: YajC; cl00806 360911007679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 360911007680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007681 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 360911007682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911007683 CHASE3 domain; Region: CHASE3; cl05000 360911007684 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 360911007685 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911007686 dimerization interface [polypeptide binding]; other site 360911007687 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911007688 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911007689 dimer interface [polypeptide binding]; other site 360911007690 putative CheW interface [polypeptide binding]; other site 360911007691 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 360911007692 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 360911007693 DHH family; Region: DHH; pfam01368 360911007694 DHHA1 domain; Region: DHHA1; pfam02272 360911007695 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 360911007696 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 360911007697 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911007698 active site 360911007699 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 360911007700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911007701 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911007702 synthetase active site [active] 360911007703 NTP binding site [chemical binding]; other site 360911007704 metal binding site [ion binding]; metal-binding site 360911007705 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 360911007706 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 360911007707 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 360911007708 putative active site [active] 360911007709 dimerization interface [polypeptide binding]; other site 360911007710 putative tRNAtyr binding site [nucleotide binding]; other site 360911007711 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 360911007712 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 360911007713 dimer interface [polypeptide binding]; other site 360911007714 motif 1; other site 360911007715 active site 360911007716 motif 2; other site 360911007717 motif 3; other site 360911007718 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 360911007719 anticodon binding site; other site 360911007720 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 360911007721 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 360911007722 dimer interface [polypeptide binding]; other site 360911007723 anticodon binding site; other site 360911007724 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 360911007725 homodimer interface [polypeptide binding]; other site 360911007726 motif 1; other site 360911007727 active site 360911007728 motif 2; other site 360911007729 GAD domain; Region: GAD; pfam02938 360911007730 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 360911007731 motif 3; other site 360911007732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 360911007733 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911007734 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 360911007735 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 360911007736 Walker A/P-loop; other site 360911007737 ATP binding site [chemical binding]; other site 360911007738 Q-loop/lid; other site 360911007739 ABC transporter signature motif; other site 360911007740 Walker B; other site 360911007741 D-loop; other site 360911007742 H-loop/switch region; other site 360911007743 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 360911007744 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911007745 putative NAD(P) binding site [chemical binding]; other site 360911007746 Predicted membrane protein [Function unknown]; Region: COG2364 360911007747 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911007748 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 360911007749 DNA photolyase; Region: DNA_photolyase; pfam00875 360911007750 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 360911007751 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 360911007752 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 360911007753 putative ATP binding site [chemical binding]; other site 360911007754 putative substrate interface [chemical binding]; other site 360911007755 recombination factor protein RarA; Reviewed; Region: PRK13342 360911007756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911007757 Walker A motif; other site 360911007758 ATP binding site [chemical binding]; other site 360911007759 Walker B motif; other site 360911007760 arginine finger; other site 360911007761 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 360911007762 Rrf2 family protein; Region: rrf2_super; TIGR00738 360911007763 Helix-turn-helix domains; Region: HTH; cl00088 360911007764 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911007765 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 360911007766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911007767 catalytic residue [active] 360911007768 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 360911007769 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 360911007770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911007771 binding surface 360911007772 Tetratricopeptide repeat; Region: TPR_16; pfam13432 360911007773 TPR motif; other site 360911007774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911007775 binding surface 360911007776 TPR motif; other site 360911007777 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911007778 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911007779 active site 360911007780 metal binding site [ion binding]; metal-binding site 360911007781 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 360911007782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911007783 Family description; Region: UvrD_C_2; cl15862 360911007784 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 360911007785 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 360911007786 motif 1; other site 360911007787 active site 360911007788 motif 2; other site 360911007789 motif 3; other site 360911007790 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 360911007791 DHHA1 domain; Region: DHHA1; pfam02272 360911007792 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 360911007793 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 360911007794 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 360911007795 YceG-like family; Region: YceG; pfam02618 360911007796 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 360911007797 dimerization interface [polypeptide binding]; other site 360911007798 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 360911007799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911007800 S-adenosylmethionine binding site [chemical binding]; other site 360911007801 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 360911007802 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 360911007803 ATP-binding site [chemical binding]; other site 360911007804 Sugar specificity; other site 360911007805 Pyrimidine base specificity; other site 360911007806 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 360911007807 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 360911007808 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 360911007809 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 360911007810 5'-methylthioadenosine nucleosidase; Region: PLN02584 360911007811 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 360911007812 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 360911007813 dimer interface [polypeptide binding]; other site 360911007814 active site 360911007815 CoA binding pocket [chemical binding]; other site 360911007816 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 360911007817 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 360911007818 dimer interface [polypeptide binding]; other site 360911007819 active site 360911007820 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 360911007821 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911007822 peptide binding site [polypeptide binding]; other site 360911007823 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 360911007824 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911007825 peptide binding site [polypeptide binding]; other site 360911007826 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 360911007827 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 360911007828 active site 360911007829 HIGH motif; other site 360911007830 dimer interface [polypeptide binding]; other site 360911007831 KMSKS motif; other site 360911007832 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 360911007833 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 360911007834 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911007835 peptide binding site [polypeptide binding]; other site 360911007836 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 360911007837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007838 dimer interface [polypeptide binding]; other site 360911007839 conserved gate region; other site 360911007840 putative PBP binding loops; other site 360911007841 ABC-ATPase subunit interface; other site 360911007842 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 360911007843 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 360911007844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007845 dimer interface [polypeptide binding]; other site 360911007846 conserved gate region; other site 360911007847 putative PBP binding loops; other site 360911007848 ABC-ATPase subunit interface; other site 360911007849 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 360911007850 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 360911007851 Walker A/P-loop; other site 360911007852 ATP binding site [chemical binding]; other site 360911007853 Q-loop/lid; other site 360911007854 ABC transporter signature motif; other site 360911007855 Walker B; other site 360911007856 D-loop; other site 360911007857 H-loop/switch region; other site 360911007858 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360911007859 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 360911007860 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 360911007861 Walker A/P-loop; other site 360911007862 ATP binding site [chemical binding]; other site 360911007863 Q-loop/lid; other site 360911007864 ABC transporter signature motif; other site 360911007865 Walker B; other site 360911007866 D-loop; other site 360911007867 H-loop/switch region; other site 360911007868 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360911007869 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911007870 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 360911007871 ArsC family; Region: ArsC; pfam03960 360911007872 putative catalytic residues [active] 360911007873 thiol/disulfide switch; other site 360911007874 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 360911007875 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 360911007876 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 360911007877 classical (c) SDRs; Region: SDR_c; cd05233 360911007878 NAD(P) binding site [chemical binding]; other site 360911007879 active site 360911007880 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 360911007881 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911007882 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911007883 putative active site [active] 360911007884 catalytic site [active] 360911007885 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911007886 putative active site [active] 360911007887 catalytic site [active] 360911007888 Competence protein CoiA-like family; Region: CoiA; cl11541 360911007889 oligoendopeptidase F; Region: pepF; TIGR00181 360911007890 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 360911007891 active site 360911007892 Zn binding site [ion binding]; other site 360911007893 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 360911007894 Thioredoxin; Region: Thioredoxin_5; pfam13743 360911007895 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 360911007896 putative active site [active] 360911007897 putative metal binding residues [ion binding]; other site 360911007898 signature motif; other site 360911007899 putative triphosphate binding site [ion binding]; other site 360911007900 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911007901 synthetase active site [active] 360911007902 NTP binding site [chemical binding]; other site 360911007903 metal binding site [ion binding]; metal-binding site 360911007904 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 360911007905 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 360911007906 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 360911007907 active site 360911007908 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 360911007909 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 360911007910 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 360911007911 NAD binding site [chemical binding]; other site 360911007912 homotetramer interface [polypeptide binding]; other site 360911007913 homodimer interface [polypeptide binding]; other site 360911007914 substrate binding site [chemical binding]; other site 360911007915 active site 360911007916 hypothetical protein; Provisional; Region: PRK13679 360911007917 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 360911007918 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 360911007919 tetramer interfaces [polypeptide binding]; other site 360911007920 binuclear metal-binding site [ion binding]; other site 360911007921 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 360911007922 active site 360911007923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911007924 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911007925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911007926 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 360911007927 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 360911007928 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 360911007929 Virulence factor; Region: Virulence_fact; pfam13769 360911007930 HEAT repeats; Region: HEAT_2; pfam13646 360911007931 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 360911007932 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 360911007933 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 360911007934 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 360911007935 homodimer interface [polypeptide binding]; other site 360911007936 NAD binding pocket [chemical binding]; other site 360911007937 ATP binding pocket [chemical binding]; other site 360911007938 Mg binding site [ion binding]; other site 360911007939 active-site loop [active] 360911007940 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 360911007941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360911007942 Helix-turn-helix domains; Region: HTH; cl00088 360911007943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 360911007944 dimerization interface [polypeptide binding]; other site 360911007945 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 360911007946 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 360911007947 metal binding site [ion binding]; metal-binding site 360911007948 putative dimer interface [polypeptide binding]; other site 360911007949 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 360911007950 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 360911007951 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 360911007952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007953 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 360911007954 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 360911007955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007956 active site 360911007957 motif I; other site 360911007958 motif II; other site 360911007959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007960 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 360911007961 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911007962 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 360911007963 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 360911007964 putative active site [active] 360911007965 putative catalytic site [active] 360911007966 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 360911007967 PLD-like domain; Region: PLDc_2; pfam13091 360911007968 putative active site [active] 360911007969 putative catalytic site [active] 360911007970 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 360911007971 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 360911007972 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 360911007973 active site 360911007974 catalytic residues [active] 360911007975 metal binding site [ion binding]; metal-binding site 360911007976 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 360911007977 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 360911007978 TPP-binding site [chemical binding]; other site 360911007979 tetramer interface [polypeptide binding]; other site 360911007980 heterodimer interface [polypeptide binding]; other site 360911007981 phosphorylation loop region [posttranslational modification] 360911007982 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 360911007983 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 360911007984 alpha subunit interface [polypeptide binding]; other site 360911007985 TPP binding site [chemical binding]; other site 360911007986 heterodimer interface [polypeptide binding]; other site 360911007987 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911007988 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 360911007989 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360911007990 E3 interaction surface; other site 360911007991 lipoyl attachment site [posttranslational modification]; other site 360911007992 e3 binding domain; Region: E3_binding; pfam02817 360911007993 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 360911007994 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 360911007995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911007996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911007997 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911007998 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911007999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911008000 Coenzyme A binding pocket [chemical binding]; other site 360911008001 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 360911008002 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 360911008003 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911008004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911008005 catalytic residue [active] 360911008006 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911008007 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 360911008008 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 360911008009 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 360911008010 active site 360911008011 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911008012 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 360911008013 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 360911008014 G1 box; other site 360911008015 putative GEF interaction site [polypeptide binding]; other site 360911008016 GTP/Mg2+ binding site [chemical binding]; other site 360911008017 Switch I region; other site 360911008018 G2 box; other site 360911008019 G3 box; other site 360911008020 Switch II region; other site 360911008021 G4 box; other site 360911008022 G5 box; other site 360911008023 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 360911008024 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 360911008025 YlaH-like protein; Region: YlaH; pfam14036 360911008026 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 360911008027 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 360911008028 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 360911008029 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 360911008030 putative active site [active] 360911008031 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911008033 drug efflux system protein MdtG; Provisional; Region: PRK09874 360911008034 putative substrate translocation pore; other site 360911008035 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 360911008036 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 360911008037 pyruvate carboxylase; Reviewed; Region: PRK12999 360911008038 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911008039 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911008040 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 360911008041 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 360911008042 active site 360911008043 catalytic residues [active] 360911008044 metal binding site [ion binding]; metal-binding site 360911008045 homodimer binding site [polypeptide binding]; other site 360911008046 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 360911008047 carboxyltransferase (CT) interaction site; other site 360911008048 biotinylation site [posttranslational modification]; other site 360911008049 DNA photolyase; Region: DNA_photolyase; pfam00875 360911008050 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 360911008051 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 360911008052 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 360911008053 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 360911008054 UbiA prenyltransferase family; Region: UbiA; cl00337 360911008055 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 360911008056 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 360911008057 Cytochrome c; Region: Cytochrom_C; cl11414 360911008058 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 360911008059 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 360911008060 D-pathway; other site 360911008061 Putative ubiquinol binding site [chemical binding]; other site 360911008062 Low-spin heme (heme b) binding site [chemical binding]; other site 360911008063 Putative water exit pathway; other site 360911008064 Binuclear center (heme o3/CuB) [ion binding]; other site 360911008065 K-pathway; other site 360911008066 Putative proton exit pathway; other site 360911008067 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 360911008068 Subunit I/III interface [polypeptide binding]; other site 360911008069 Subunit III/IV interface [polypeptide binding]; other site 360911008070 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 360911008071 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 360911008072 Protein of unknown function (DUF420); Region: DUF420; cl00989 360911008073 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 360911008074 Cu(I) binding site [ion binding]; other site 360911008075 YugN-like family; Region: YugN; pfam08868 360911008076 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911008077 Protein of unknown function (DUF964); Region: DUF964; cl01483 360911008078 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 360911008079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911008080 S-adenosylmethionine binding site [chemical binding]; other site 360911008081 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 360911008082 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 360911008083 active site 360911008084 (T/H)XGH motif; other site 360911008085 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 360911008086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911008087 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 360911008088 hypothetical protein; Provisional; Region: PRK13670 360911008089 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360911008090 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 360911008091 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 360911008092 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 360911008093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008094 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 360911008095 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 360911008096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 360911008097 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 360911008098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008099 Septum formation initiator; Region: DivIC; cl11433 360911008100 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 360911008101 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360911008102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911008103 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 360911008104 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 360911008105 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 360911008106 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911008107 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911008108 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911008109 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 360911008110 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 360911008111 Mg++ binding site [ion binding]; other site 360911008112 putative catalytic motif [active] 360911008113 putative substrate binding site [chemical binding]; other site 360911008114 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 360911008115 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911008116 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911008117 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 360911008118 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 360911008119 active site 360911008120 homodimer interface [polypeptide binding]; other site 360911008121 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 360911008122 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 360911008123 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 360911008124 Cell division protein FtsA; Region: FtsA; cl11496 360911008125 Cell division protein FtsA; Region: FtsA; cl11496 360911008126 cell division protein FtsZ; Validated; Region: PRK09330 360911008127 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 360911008128 nucleotide binding site [chemical binding]; other site 360911008129 SulA interaction site; other site 360911008130 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 360911008131 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 360911008132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 360911008133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911008134 catalytic residue [active] 360911008135 Protein of unknown function (DUF552); Region: DUF552; cl00775 360911008136 YGGT family; Region: YGGT; cl00508 360911008137 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 360911008138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911008139 RNA binding surface [nucleotide binding]; other site 360911008140 DivIVA protein; Region: DivIVA; pfam05103 360911008141 DivIVA domain; Region: DivI1A_domain; TIGR03544 360911008142 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 360911008143 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360911008144 active site 360911008145 HIGH motif; other site 360911008146 nucleotide binding site [chemical binding]; other site 360911008147 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 360911008148 active site 360911008149 KMSKS motif; other site 360911008150 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 360911008151 tRNA binding surface [nucleotide binding]; other site 360911008152 anticodon binding site; other site 360911008153 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 360911008154 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 360911008155 lipoprotein signal peptidase; Provisional; Region: PRK14787 360911008156 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 360911008157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911008158 RNA binding surface [nucleotide binding]; other site 360911008159 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 360911008160 active site 360911008161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911008162 active site 360911008163 uracil transporter; Provisional; Region: PRK10720 360911008164 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 360911008165 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 360911008166 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360911008167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008168 dihydroorotase; Validated; Region: pyrC; PRK09357 360911008169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911008170 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 360911008171 active site 360911008172 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 360911008173 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 360911008174 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 360911008175 catalytic site [active] 360911008176 subunit interface [polypeptide binding]; other site 360911008177 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 360911008178 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911008179 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911008180 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 360911008181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911008182 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911008183 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 360911008184 IMP binding site; other site 360911008185 dimer interface [polypeptide binding]; other site 360911008186 interdomain contacts; other site 360911008187 partial ornithine binding site; other site 360911008188 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 360911008189 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 360911008190 FAD binding pocket [chemical binding]; other site 360911008191 FAD binding motif [chemical binding]; other site 360911008192 phosphate binding motif [ion binding]; other site 360911008193 beta-alpha-beta structure motif; other site 360911008194 NAD binding pocket [chemical binding]; other site 360911008195 Iron coordination center [ion binding]; other site 360911008196 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 360911008197 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 360911008198 heterodimer interface [polypeptide binding]; other site 360911008199 active site 360911008200 FMN binding site [chemical binding]; other site 360911008201 homodimer interface [polypeptide binding]; other site 360911008202 substrate binding site [chemical binding]; other site 360911008203 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 360911008204 active site 360911008205 dimer interface [polypeptide binding]; other site 360911008206 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 360911008207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911008208 active site 360911008209 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 360911008210 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 360911008211 Domain of unknown function (DUF814); Region: DUF814; pfam05670 360911008212 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 360911008213 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 360911008214 catalytic site [active] 360911008215 G-X2-G-X-G-K; other site 360911008216 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 360911008217 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 360911008218 Flavoprotein; Region: Flavoprotein; cl08021 360911008219 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 360911008220 primosome assembly protein PriA; Validated; Region: PRK05580 360911008221 primosome assembly protein PriA; Validated; Region: PRK05580 360911008222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911008223 ATP binding site [chemical binding]; other site 360911008224 putative Mg++ binding site [ion binding]; other site 360911008225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911008226 nucleotide binding region [chemical binding]; other site 360911008227 ATP-binding site [chemical binding]; other site 360911008228 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 360911008229 active site 360911008230 catalytic residues [active] 360911008231 metal binding site [ion binding]; metal-binding site 360911008232 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 360911008233 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 360911008234 putative active site [active] 360911008235 substrate binding site [chemical binding]; other site 360911008236 putative cosubstrate binding site; other site 360911008237 catalytic site [active] 360911008238 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 360911008239 substrate binding site [chemical binding]; other site 360911008240 16S rRNA methyltransferase B; Provisional; Region: PRK14902 360911008241 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 360911008242 putative RNA binding site [nucleotide binding]; other site 360911008243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911008244 S-adenosylmethionine binding site [chemical binding]; other site 360911008245 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 360911008246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911008247 FeS/SAM binding site; other site 360911008248 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 360911008249 Protein phosphatase 2C; Region: PP2C; pfam00481 360911008250 active site 360911008251 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911008252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 360911008253 active site 360911008254 ATP binding site [chemical binding]; other site 360911008255 substrate binding site [chemical binding]; other site 360911008256 activation loop (A-loop); other site 360911008257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 360911008258 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 360911008259 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 360911008260 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 360911008261 GTPase RsgA; Reviewed; Region: PRK00098 360911008262 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 360911008263 RNA binding site [nucleotide binding]; other site 360911008264 homodimer interface [polypeptide binding]; other site 360911008265 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 360911008266 GTPase/Zn-binding domain interface [polypeptide binding]; other site 360911008267 GTP/Mg2+ binding site [chemical binding]; other site 360911008268 G4 box; other site 360911008269 G5 box; other site 360911008270 G1 box; other site 360911008271 Switch I region; other site 360911008272 G2 box; other site 360911008273 G3 box; other site 360911008274 Switch II region; other site 360911008275 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 360911008276 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 360911008277 substrate binding site [chemical binding]; other site 360911008278 hexamer interface [polypeptide binding]; other site 360911008279 metal binding site [ion binding]; metal-binding site 360911008280 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 360911008281 Thiamine pyrophosphokinase; Region: TPK; cd07995 360911008282 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 360911008283 active site 360911008284 dimerization interface [polypeptide binding]; other site 360911008285 thiamine binding site [chemical binding]; other site 360911008286 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 360911008287 Asp23 family; Region: Asp23; cl00574 360911008288 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 360911008289 DAK2 domain; Region: Dak2; cl03685 360911008290 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 360911008291 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 360911008292 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 360911008293 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 360911008294 putative L-serine binding site [chemical binding]; other site 360911008295 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 360911008296 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 360911008297 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 360911008298 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 360911008299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911008300 ATP binding site [chemical binding]; other site 360911008301 putative Mg++ binding site [ion binding]; other site 360911008302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911008303 nucleotide binding region [chemical binding]; other site 360911008304 ATP-binding site [chemical binding]; other site 360911008305 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 360911008306 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 360911008307 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 360911008308 Acyl transferase domain; Region: Acyl_transf_1; cl08282 360911008309 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 360911008310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 360911008311 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 360911008312 NAD(P) binding site [chemical binding]; other site 360911008313 homotetramer interface [polypeptide binding]; other site 360911008314 homodimer interface [polypeptide binding]; other site 360911008315 active site 360911008316 Phosphopantetheine attachment site; Region: PP-binding; cl09936 360911008317 ribonuclease III; Reviewed; Region: rnc; PRK00102 360911008318 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 360911008319 dimerization interface [polypeptide binding]; other site 360911008320 active site 360911008321 metal binding site [ion binding]; metal-binding site 360911008322 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 360911008323 dsRNA binding site [nucleotide binding]; other site 360911008324 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 360911008325 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 360911008326 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 360911008327 Walker A/P-loop; other site 360911008328 ATP binding site [chemical binding]; other site 360911008329 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 360911008330 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 360911008331 ABC transporter signature motif; other site 360911008332 Walker B; other site 360911008333 D-loop; other site 360911008334 H-loop/switch region; other site 360911008335 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 360911008336 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 360911008337 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 360911008338 P loop; other site 360911008339 GTP binding site [chemical binding]; other site 360911008340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 360911008341 signal recognition particle protein; Provisional; Region: PRK10867 360911008342 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 360911008343 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 360911008344 P loop; other site 360911008345 GTP binding site [chemical binding]; other site 360911008346 Signal peptide binding domain; Region: SRP_SPB; pfam02978 360911008347 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 360911008348 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 360911008349 RimM N-terminal domain; Region: RimM; pfam01782 360911008350 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 360911008351 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 360911008352 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 360911008353 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 360911008354 Catalytic site [active] 360911008355 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 360911008356 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 360911008357 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 360911008358 GTP/Mg2+ binding site [chemical binding]; other site 360911008359 G4 box; other site 360911008360 G5 box; other site 360911008361 G1 box; other site 360911008362 Switch I region; other site 360911008363 G2 box; other site 360911008364 G3 box; other site 360911008365 Switch II region; other site 360911008366 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 360911008367 RNA/DNA hybrid binding site [nucleotide binding]; other site 360911008368 active site 360911008369 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 360911008370 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 360911008371 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911008372 CoA-ligase; Region: Ligase_CoA; cl02894 360911008373 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 360911008374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008375 CoA-ligase; Region: Ligase_CoA; cl02894 360911008376 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 360911008377 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 360911008378 DNA topoisomerase I; Validated; Region: PRK05582 360911008379 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 360911008380 active site 360911008381 interdomain interaction site; other site 360911008382 putative metal-binding site [ion binding]; other site 360911008383 nucleotide binding site [chemical binding]; other site 360911008384 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 360911008385 domain I; other site 360911008386 DNA binding groove [nucleotide binding] 360911008387 phosphate binding site [ion binding]; other site 360911008388 domain II; other site 360911008389 domain III; other site 360911008390 nucleotide binding site [chemical binding]; other site 360911008391 catalytic site [active] 360911008392 domain IV; other site 360911008393 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911008394 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911008395 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 360911008396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008397 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 360911008398 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911008399 active site 360911008400 DNA binding site [nucleotide binding] 360911008401 Int/Topo IB signature motif; other site 360911008402 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 360911008403 active site 360911008404 HslU subunit interaction site [polypeptide binding]; other site 360911008405 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 360911008406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911008407 Walker A motif; other site 360911008408 ATP binding site [chemical binding]; other site 360911008409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008410 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 360911008411 transcriptional repressor CodY; Validated; Region: PRK04158 360911008412 CodY GAF-like domain; Region: CodY; pfam06018 360911008413 Helix-turn-helix domains; Region: HTH; cl00088 360911008414 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 360911008415 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 360911008416 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 360911008417 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 360911008418 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 360911008419 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 360911008420 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 360911008421 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 360911008422 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 360911008423 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 360911008424 FliG C-terminal domain; Region: FliG_C; pfam01706 360911008425 flagellar assembly protein H; Validated; Region: fliH; PRK06669 360911008426 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 360911008427 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 360911008428 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 360911008429 Walker A motif/ATP binding site; other site 360911008430 Walker B motif; other site 360911008431 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 360911008432 Flagellar FliJ protein; Region: FliJ; pfam02050 360911008433 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 360911008434 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 360911008435 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 360911008436 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 360911008437 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 360911008438 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 360911008439 Flagellar protein (FlbD); Region: FlbD; cl00683 360911008440 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 360911008441 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 360911008442 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 360911008443 flagellar motor switch protein; Validated; Region: PRK08119 360911008444 Chemotaxis phosphatase CheX; Region: CheX; cl15816 360911008445 Chemotaxis phosphatase CheX; Region: CheX; cl15816 360911008446 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 360911008447 Response regulator receiver domain; Region: Response_reg; pfam00072 360911008448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911008449 active site 360911008450 phosphorylation site [posttranslational modification] 360911008451 intermolecular recognition site; other site 360911008452 dimerization interface [polypeptide binding]; other site 360911008453 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 360911008454 FliP family; Region: FliP; cl00593 360911008455 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 360911008456 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 360911008457 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 360911008458 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 360911008459 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 360911008460 FHIPEP family; Region: FHIPEP; pfam00771 360911008461 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 360911008462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008463 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 360911008464 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 360911008465 P-loop; other site 360911008466 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 360911008467 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 360911008468 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 360911008469 putative binding surface; other site 360911008470 active site 360911008471 P2 response regulator binding domain; Region: P2; pfam07194 360911008472 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 360911008473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911008474 ATP binding site [chemical binding]; other site 360911008475 Mg2+ binding site [ion binding]; other site 360911008476 G-X-G motif; other site 360911008477 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 360911008478 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 360911008479 putative CheA interaction surface; other site 360911008480 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 360911008481 Chemotaxis phosphatase CheX; Region: CheX; cl15816 360911008482 Chemotaxis phosphatase CheX; Region: CheX; cl15816 360911008483 CheD chemotactic sensory transduction; Region: CheD; cl00810 360911008484 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 360911008485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911008486 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360911008487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911008488 DNA binding residues [nucleotide binding] 360911008489 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 360911008490 rRNA interaction site [nucleotide binding]; other site 360911008491 S8 interaction site; other site 360911008492 putative laminin-1 binding site; other site 360911008493 elongation factor Ts; Provisional; Region: tsf; PRK09377 360911008494 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 360911008495 Elongation factor TS; Region: EF_TS; pfam00889 360911008496 Elongation factor TS; Region: EF_TS; pfam00889 360911008497 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 360911008498 putative nucleotide binding site [chemical binding]; other site 360911008499 uridine monophosphate binding site [chemical binding]; other site 360911008500 homohexameric interface [polypeptide binding]; other site 360911008501 ribosome recycling factor; Reviewed; Region: frr; PRK00083 360911008502 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 360911008503 hinge region; other site 360911008504 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 360911008505 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 360911008506 catalytic residue [active] 360911008507 putative FPP diphosphate binding site; other site 360911008508 putative FPP binding hydrophobic cleft; other site 360911008509 dimer interface [polypeptide binding]; other site 360911008510 putative IPP diphosphate binding site; other site 360911008511 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 360911008512 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 360911008513 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 360911008514 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 360911008515 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 360911008516 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 360911008517 RIP metalloprotease RseP; Region: TIGR00054 360911008518 active site 360911008519 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 360911008520 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 360911008521 protein binding site [polypeptide binding]; other site 360911008522 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 360911008523 putative substrate binding region [chemical binding]; other site 360911008524 prolyl-tRNA synthetase; Provisional; Region: PRK09194 360911008525 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 360911008526 dimer interface [polypeptide binding]; other site 360911008527 motif 1; other site 360911008528 active site 360911008529 motif 2; other site 360911008530 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 360911008531 putative deacylase active site [active] 360911008532 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 360911008533 active site 360911008534 motif 3; other site 360911008535 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 360911008536 anticodon binding site; other site 360911008537 DNA polymerase III PolC; Validated; Region: polC; PRK00448 360911008538 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 360911008539 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 360911008540 generic binding surface II; other site 360911008541 generic binding surface I; other site 360911008542 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 360911008543 active site 360911008544 catalytic site [active] 360911008545 substrate binding site [chemical binding]; other site 360911008546 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 360911008547 ribosome maturation protein RimP; Reviewed; Region: PRK00092 360911008548 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 360911008549 Sm1 motif; other site 360911008550 predicted subunit interaction site [polypeptide binding]; other site 360911008551 RNA binding pocket [nucleotide binding]; other site 360911008552 Sm2 motif; other site 360911008553 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 360911008554 NusA N-terminal domain; Region: NusA_N; pfam08529 360911008555 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 360911008556 RNA binding site [nucleotide binding]; other site 360911008557 homodimer interface [polypeptide binding]; other site 360911008558 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 360911008559 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 360911008560 G-X-X-G motif; other site 360911008561 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 360911008562 putative RNA binding cleft [nucleotide binding]; other site 360911008563 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 360911008564 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 360911008565 translation initiation factor IF-2; Region: IF-2; TIGR00487 360911008566 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 360911008567 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 360911008568 G1 box; other site 360911008569 putative GEF interaction site [polypeptide binding]; other site 360911008570 GTP/Mg2+ binding site [chemical binding]; other site 360911008571 Switch I region; other site 360911008572 G2 box; other site 360911008573 G3 box; other site 360911008574 Switch II region; other site 360911008575 G4 box; other site 360911008576 G5 box; other site 360911008577 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 360911008578 Translation-initiation factor 2; Region: IF-2; pfam11987 360911008579 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 360911008580 Ribosome-binding factor A; Region: RBFA; cl00542 360911008581 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 360911008582 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 360911008583 RNA binding site [nucleotide binding]; other site 360911008584 active site 360911008585 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 360911008586 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 360911008587 active site 360911008588 Riboflavin kinase; Region: Flavokinase; cl03312 360911008589 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 360911008590 16S/18S rRNA binding site [nucleotide binding]; other site 360911008591 S13e-L30e interaction site [polypeptide binding]; other site 360911008592 25S rRNA binding site [nucleotide binding]; other site 360911008593 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 360911008594 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 360911008595 RNase E interface [polypeptide binding]; other site 360911008596 trimer interface [polypeptide binding]; other site 360911008597 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 360911008598 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 360911008599 RNase E interface [polypeptide binding]; other site 360911008600 trimer interface [polypeptide binding]; other site 360911008601 active site 360911008602 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 360911008603 putative nucleic acid binding region [nucleotide binding]; other site 360911008604 G-X-X-G motif; other site 360911008605 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 360911008606 RNA binding site [nucleotide binding]; other site 360911008607 domain interface; other site 360911008608 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 360911008609 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 360911008610 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360911008611 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 360911008612 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911008613 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911008614 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911008615 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 360911008616 Peptidase M15; Region: Peptidase_M15_3; cl01194 360911008617 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 360911008618 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 360911008619 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911008620 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 360911008621 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 360911008622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008623 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 360911008624 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 360911008625 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911008626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911008627 DNA-binding site [nucleotide binding]; DNA binding site 360911008628 UTRA domain; Region: UTRA; cl01230 360911008629 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 360911008630 ligand binding site [chemical binding]; other site 360911008631 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 360911008632 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 360911008633 Walker A/P-loop; other site 360911008634 ATP binding site [chemical binding]; other site 360911008635 Q-loop/lid; other site 360911008636 ABC transporter signature motif; other site 360911008637 Walker B; other site 360911008638 D-loop; other site 360911008639 H-loop/switch region; other site 360911008640 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 360911008641 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 360911008642 TM-ABC transporter signature motif; other site 360911008643 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 360911008644 TM-ABC transporter signature motif; other site 360911008645 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 360911008646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 360911008647 Helix-turn-helix domains; Region: HTH; cl00088 360911008648 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 360911008649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911008650 ATP binding site [chemical binding]; other site 360911008651 putative Mg++ binding site [ion binding]; other site 360911008652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911008653 nucleotide binding region [chemical binding]; other site 360911008654 ATP-binding site [chemical binding]; other site 360911008655 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911008656 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 360911008657 DNA binding residues [nucleotide binding] 360911008658 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 360911008659 B12 binding site [chemical binding]; other site 360911008660 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 360911008661 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 360911008662 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 360911008663 ATP-grasp domain; Region: ATP-grasp_4; cl03087 360911008664 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 360911008665 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 360911008666 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 360911008667 NAD(P) binding site [chemical binding]; other site 360911008668 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 360911008669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911008671 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 360911008672 active site 360911008673 homotetramer interface [polypeptide binding]; other site 360911008674 homodimer interface [polypeptide binding]; other site 360911008675 Protease prsW family; Region: PrsW-protease; cl15823 360911008676 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 360911008677 Flagellar protein YcgR; Region: YcgR_2; pfam12945 360911008678 PilZ domain; Region: PilZ; cl01260 360911008679 cytidylate kinase; Provisional; Region: cmk; PRK00023 360911008680 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 360911008681 CMP-binding site; other site 360911008682 The sites determining sugar specificity; other site 360911008683 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 360911008684 putative acyl-acceptor binding pocket; other site 360911008685 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 360911008686 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 360911008687 RNA binding site [nucleotide binding]; other site 360911008688 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 360911008689 RNA binding site [nucleotide binding]; other site 360911008690 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 360911008691 RNA binding site [nucleotide binding]; other site 360911008692 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911008693 RNA binding site [nucleotide binding]; other site 360911008694 GTP-binding protein Der; Reviewed; Region: PRK00093 360911008695 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 360911008696 G1 box; other site 360911008697 GTP/Mg2+ binding site [chemical binding]; other site 360911008698 Switch I region; other site 360911008699 G2 box; other site 360911008700 Switch II region; other site 360911008701 G3 box; other site 360911008702 G4 box; other site 360911008703 G5 box; other site 360911008704 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 360911008705 G1 box; other site 360911008706 GTP/Mg2+ binding site [chemical binding]; other site 360911008707 Switch I region; other site 360911008708 G2 box; other site 360911008709 G3 box; other site 360911008710 Switch II region; other site 360911008711 G4 box; other site 360911008712 G5 box; other site 360911008713 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 360911008714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008715 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 360911008716 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 360911008717 IHF dimer interface [polypeptide binding]; other site 360911008718 IHF - DNA interface [nucleotide binding]; other site 360911008719 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 360911008720 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 360911008721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911008722 S-adenosylmethionine binding site [chemical binding]; other site 360911008723 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 360911008724 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 360911008725 substrate binding pocket [chemical binding]; other site 360911008726 chain length determination region; other site 360911008727 substrate-Mg2+ binding site; other site 360911008728 catalytic residues [active] 360911008729 aspartate-rich region 1; other site 360911008730 active site lid residues [active] 360911008731 aspartate-rich region 2; other site 360911008732 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 360911008733 active site 360911008734 multimer interface [polypeptide binding]; other site 360911008735 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 360911008736 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 360911008737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911008738 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 360911008739 Tetramer interface [polypeptide binding]; other site 360911008740 active site 360911008741 FMN-binding site [chemical binding]; other site 360911008742 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 360911008743 active site 360911008744 dimer interface [polypeptide binding]; other site 360911008745 metal binding site [ion binding]; metal-binding site 360911008746 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 360911008747 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 360911008748 hinge; other site 360911008749 active site 360911008750 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 360911008751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 360911008752 binding surface 360911008753 TPR motif; other site 360911008754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911008755 binding surface 360911008756 TPR motif; other site 360911008757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911008758 binding surface 360911008759 TPR motif; other site 360911008760 hypothetical protein; Provisional; Region: PRK03636 360911008761 UPF0302 domain; Region: UPF0302; pfam08864 360911008762 IDEAL domain; Region: IDEAL; cl07452 360911008763 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 360911008764 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 360911008765 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 360911008766 iron-sulfur cluster [ion binding]; other site 360911008767 [2Fe-2S] cluster binding site [ion binding]; other site 360911008768 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 360911008769 interchain domain interface [polypeptide binding]; other site 360911008770 intrachain domain interface; other site 360911008771 heme bH binding site [chemical binding]; other site 360911008772 heme bL binding site [chemical binding]; other site 360911008773 Qo binding site; other site 360911008774 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 360911008775 Cytochrome c; Region: Cytochrom_C; cl11414 360911008776 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 360911008777 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 360911008778 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 360911008779 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911008780 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911008781 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911008782 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 360911008783 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 360911008784 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 360911008785 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 360911008786 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 360911008787 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 360911008788 active site 360911008789 NTP binding site [chemical binding]; other site 360911008790 metal binding triad [ion binding]; metal-binding site 360911008791 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 360911008792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 360911008793 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 360911008794 Helix-turn-helix domains; Region: HTH; cl00088 360911008795 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 360911008796 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 360911008797 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 360911008798 oligomerization interface [polypeptide binding]; other site 360911008799 active site 360911008800 metal binding site [ion binding]; metal-binding site 360911008801 pantoate--beta-alanine ligase; Region: panC; TIGR00018 360911008802 Pantoate-beta-alanine ligase; Region: PanC; cd00560 360911008803 active site 360911008804 ATP-binding site [chemical binding]; other site 360911008805 pantoate-binding site; other site 360911008806 HXXH motif; other site 360911008807 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 360911008808 tetramerization interface [polypeptide binding]; other site 360911008809 active site 360911008810 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 360911008811 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 360911008812 active site 360911008813 catalytic site [active] 360911008814 substrate binding site [chemical binding]; other site 360911008815 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008817 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 360911008818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 360911008819 aspartate aminotransferase; Provisional; Region: PRK05764 360911008820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911008821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911008822 homodimer interface [polypeptide binding]; other site 360911008823 catalytic residue [active] 360911008824 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 360911008825 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 360911008826 putative dimer interface [polypeptide binding]; other site 360911008827 putative anticodon binding site; other site 360911008828 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 360911008829 homodimer interface [polypeptide binding]; other site 360911008830 motif 1; other site 360911008831 motif 2; other site 360911008832 active site 360911008833 motif 3; other site 360911008834 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 360911008835 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 360911008836 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 360911008837 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360911008838 minor groove reading motif; other site 360911008839 helix-hairpin-helix signature motif; other site 360911008840 substrate binding pocket [chemical binding]; other site 360911008841 active site 360911008842 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 360911008843 Recombination protein U; Region: RecU; cl01314 360911008844 Transglycosylase; Region: Transgly; cl07896 360911008845 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 360911008846 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 360911008847 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 360911008848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911008849 ATP binding site [chemical binding]; other site 360911008850 putative Mg++ binding site [ion binding]; other site 360911008851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911008852 nucleotide binding region [chemical binding]; other site 360911008853 ATP-binding site [chemical binding]; other site 360911008854 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 360911008855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911008856 non-specific DNA binding site [nucleotide binding]; other site 360911008857 salt bridge; other site 360911008858 sequence-specific DNA binding site [nucleotide binding]; other site 360911008859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911008860 non-specific DNA binding site [nucleotide binding]; other site 360911008861 salt bridge; other site 360911008862 sequence-specific DNA binding site [nucleotide binding]; other site 360911008863 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 360911008864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008865 Walker A/P-loop; other site 360911008866 ATP binding site [chemical binding]; other site 360911008867 HNH endonuclease; Region: HNH_3; pfam13392 360911008868 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 360911008869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 360911008870 Q-loop/lid; other site 360911008871 ABC transporter signature motif; other site 360911008872 Walker B; other site 360911008873 D-loop; other site 360911008874 H-loop/switch region; other site 360911008875 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 360911008876 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911008877 active site 360911008878 metal binding site [ion binding]; metal-binding site 360911008879 DNA binding site [nucleotide binding]