-- dump date 20120504_144624 -- class Genbank::misc_feature -- table misc_feature_note -- id note 401614000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 401614000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 401614000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614000004 Walker A motif; other site 401614000005 ATP binding site [chemical binding]; other site 401614000006 Walker B motif; other site 401614000007 arginine finger; other site 401614000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 401614000009 DnaA box-binding interface [nucleotide binding]; other site 401614000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 401614000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 401614000012 putative DNA binding surface [nucleotide binding]; other site 401614000013 dimer interface [polypeptide binding]; other site 401614000014 beta-clamp/clamp loader binding surface; other site 401614000015 beta-clamp/translesion DNA polymerase binding surface; other site 401614000016 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614000017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000019 Amino acid permease; Region: AA_permease_2; pfam13520 401614000020 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 401614000021 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 401614000022 EamA-like transporter family; Region: EamA; cl01037 401614000023 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 401614000024 Terminase small subunit; Region: Terminase_2; cl01513 401614000025 AAA domain; Region: AAA_25; pfam13481 401614000026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614000027 Walker A motif; other site 401614000028 ATP binding site [chemical binding]; other site 401614000029 Walker B motif; other site 401614000030 Helix-turn-helix domains; Region: HTH; cl00088 401614000031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 401614000032 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 401614000033 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 401614000034 integrase; Provisional; Region: PRK09692 401614000035 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 401614000036 active site 401614000037 Int/Topo IB signature motif; other site 401614000038 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614000039 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614000040 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 401614000041 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 401614000042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614000043 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 401614000044 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614000045 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614000046 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 401614000047 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614000048 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614000049 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 401614000050 substrate binding site [chemical binding]; other site 401614000051 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 401614000052 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 401614000053 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 401614000054 catalytic site [active] 401614000055 subunit interface [polypeptide binding]; other site 401614000056 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 401614000057 catalytic core [active] 401614000058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614000059 dihydroorotase; Reviewed; Region: PRK09236 401614000060 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401614000061 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 401614000062 active site 401614000063 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 401614000064 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 401614000065 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614000066 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614000067 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614000068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614000069 Helix-turn-helix domains; Region: HTH; cl00088 401614000070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614000071 dimerization interface [polypeptide binding]; other site 401614000072 SOUL heme-binding protein; Region: SOUL; pfam04832 401614000073 Chorismate mutase type II; Region: CM_2; cl00693 401614000074 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 401614000075 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 401614000076 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 401614000077 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 401614000078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 401614000079 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 401614000080 active site 401614000081 dimer interface [polypeptide binding]; other site 401614000082 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 401614000083 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 401614000084 phosphate binding site [ion binding]; other site 401614000085 Protein of unknown function (DUF770); Region: DUF770; cl01402 401614000086 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 401614000087 Protein of unknown function (DUF877); Region: DUF877; pfam05943 401614000088 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 401614000089 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 401614000090 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 401614000091 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 401614000092 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 401614000093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614000094 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 401614000095 putative active site [active] 401614000096 dimerization interface [polypeptide binding]; other site 401614000097 putative tRNAtyr binding site [nucleotide binding]; other site 401614000098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614000099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000100 putative substrate translocation pore; other site 401614000101 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 401614000102 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 401614000103 substrate binding [chemical binding]; other site 401614000104 active site 401614000105 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 401614000106 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 401614000107 tartrate dehydrogenase; Provisional; Region: PRK08194 401614000108 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 401614000109 substrate binding site [chemical binding]; other site 401614000110 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 401614000111 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 401614000112 substrate binding site [chemical binding]; other site 401614000113 ligand binding site [chemical binding]; other site 401614000114 2-isopropylmalate synthase; Validated; Region: PRK00915 401614000115 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 401614000116 active site 401614000117 catalytic residues [active] 401614000118 metal binding site [ion binding]; metal-binding site 401614000119 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 401614000120 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 401614000121 homodimer interface [polypeptide binding]; other site 401614000122 substrate-cofactor binding pocket; other site 401614000123 catalytic residue [active] 401614000124 pyruvate phosphate dikinase; Provisional; Region: PRK09279 401614000125 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 401614000126 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 401614000127 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 401614000128 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 401614000129 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 401614000130 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 401614000131 G1 box; other site 401614000132 GTP/Mg2+ binding site [chemical binding]; other site 401614000133 Switch I region; other site 401614000134 G2 box; other site 401614000135 G3 box; other site 401614000136 Switch II region; other site 401614000137 G4 box; other site 401614000138 G5 box; other site 401614000139 Nucleoside recognition; Region: Gate; cl00486 401614000140 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 401614000141 Nucleoside recognition; Region: Gate; cl00486 401614000142 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 401614000143 putative active site [active] 401614000144 putative substrate binding site [chemical binding]; other site 401614000145 catalytic site [active] 401614000146 dimer interface [polypeptide binding]; other site 401614000147 elongation factor P; Validated; Region: PRK00529 401614000148 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 401614000149 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 401614000150 RNA binding site [nucleotide binding]; other site 401614000151 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 401614000152 RNA binding site [nucleotide binding]; other site 401614000153 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 401614000154 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 401614000155 putative acyl-acceptor binding pocket; other site 401614000156 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 401614000157 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 401614000158 putative acyl-acceptor binding pocket; other site 401614000159 membrane protein insertase; Provisional; Region: PRK01318 401614000160 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 401614000161 Haemolytic domain; Region: Haemolytic; cl00506 401614000162 Ribonuclease P; Region: Ribonuclease_P; cl00457 401614000163 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 401614000164 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 401614000165 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 401614000166 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 401614000167 shikimate binding site; other site 401614000168 NAD(P) binding site [chemical binding]; other site 401614000169 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 401614000170 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614000171 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614000172 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614000173 Predicted methyltransferases [General function prediction only]; Region: COG0313 401614000174 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 401614000175 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 401614000176 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614000177 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 401614000178 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 401614000179 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 401614000180 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 401614000181 PLD-like domain; Region: PLDc_2; pfam13091 401614000182 putative homodimer interface [polypeptide binding]; other site 401614000183 putative active site [active] 401614000184 catalytic site [active] 401614000185 DEAD-like helicases superfamily; Region: DEXDc; smart00487 401614000186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614000187 ATP binding site [chemical binding]; other site 401614000188 putative Mg++ binding site [ion binding]; other site 401614000189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614000190 nucleotide binding region [chemical binding]; other site 401614000191 ATP-binding site [chemical binding]; other site 401614000192 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 401614000193 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401614000194 Ligand Binding Site [chemical binding]; other site 401614000195 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401614000196 Ligand Binding Site [chemical binding]; other site 401614000197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000198 putative substrate translocation pore; other site 401614000199 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 401614000200 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 401614000201 LamB/YcsF family; Region: LamB_YcsF; cl00664 401614000202 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 401614000203 Phosphoesterase family; Region: Phosphoesterase; cl15450 401614000204 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 401614000205 Phosphate transporter family; Region: PHO4; cl00396 401614000206 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 401614000207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614000208 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 401614000209 putative FMN binding site [chemical binding]; other site 401614000210 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 401614000211 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614000212 aromatic amino acid transport protein; Region: araaP; TIGR00837 401614000213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614000214 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 401614000215 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614000216 catalytic residue [active] 401614000217 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 401614000218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614000219 Helix-turn-helix domains; Region: HTH; cl00088 401614000220 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614000221 putative effector binding pocket; other site 401614000222 dimerization interface [polypeptide binding]; other site 401614000223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000224 putative substrate translocation pore; other site 401614000225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614000226 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 401614000227 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 401614000228 dimer interface [polypeptide binding]; other site 401614000229 active site 401614000230 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 401614000231 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 401614000232 GTP-binding protein LepA; Provisional; Region: PRK05433 401614000233 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 401614000234 G1 box; other site 401614000235 putative GEF interaction site [polypeptide binding]; other site 401614000236 GTP/Mg2+ binding site [chemical binding]; other site 401614000237 Switch I region; other site 401614000238 G2 box; other site 401614000239 G3 box; other site 401614000240 Switch II region; other site 401614000241 G4 box; other site 401614000242 G5 box; other site 401614000243 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 401614000244 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 401614000245 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 401614000246 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 401614000247 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 401614000248 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 401614000249 active site 401614000250 catalytic residues [active] 401614000251 metal binding site [ion binding]; metal-binding site 401614000252 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 401614000253 homopentamer interface [polypeptide binding]; other site 401614000254 active site 401614000255 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 401614000256 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 401614000257 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 401614000258 dimerization interface [polypeptide binding]; other site 401614000259 active site 401614000260 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 401614000261 Lumazine binding domain; Region: Lum_binding; pfam00677 401614000262 Lumazine binding domain; Region: Lum_binding; pfam00677 401614000263 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 401614000264 catalytic motif [active] 401614000265 Zn binding site [ion binding]; other site 401614000266 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 401614000267 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 401614000268 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 401614000269 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 401614000270 dimer interface [polypeptide binding]; other site 401614000271 PYR/PP interface [polypeptide binding]; other site 401614000272 TPP binding site [chemical binding]; other site 401614000273 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 401614000274 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 401614000275 TPP-binding site [chemical binding]; other site 401614000276 dimer interface [polypeptide binding]; other site 401614000277 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 401614000278 dimer interface [polypeptide binding]; other site 401614000279 [2Fe-2S] cluster binding site [ion binding]; other site 401614000280 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 401614000281 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 401614000282 tandem repeat interface [polypeptide binding]; other site 401614000283 oligomer interface [polypeptide binding]; other site 401614000284 active site residues [active] 401614000285 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 401614000286 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 401614000287 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 401614000288 SecA binding site; other site 401614000289 Preprotein binding site; other site 401614000290 recombinase A; Provisional; Region: recA; PRK09354 401614000291 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 401614000292 hexamer interface [polypeptide binding]; other site 401614000293 Walker A motif; other site 401614000294 ATP binding site [chemical binding]; other site 401614000295 Walker B motif; other site 401614000296 RecX family; Region: RecX; cl00936 401614000297 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 401614000298 dimer interface [polypeptide binding]; other site 401614000299 ssDNA binding site [nucleotide binding]; other site 401614000300 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401614000301 propionate/acetate kinase; Provisional; Region: PRK12379 401614000302 Acetokinase family; Region: Acetate_kinase; cl01029 401614000303 phosphate acetyltransferase; Reviewed; Region: PRK05632 401614000304 DRTGG domain; Region: DRTGG; cl12147 401614000305 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 401614000306 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 401614000307 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 401614000308 tetramerization interface [polypeptide binding]; other site 401614000309 NAD(P) binding site [chemical binding]; other site 401614000310 catalytic residues [active] 401614000311 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614000312 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 401614000313 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 401614000314 dimer interface [polypeptide binding]; other site 401614000315 anticodon binding site; other site 401614000316 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 401614000317 homodimer interface [polypeptide binding]; other site 401614000318 motif 1; other site 401614000319 active site 401614000320 motif 2; other site 401614000321 GAD domain; Region: GAD; pfam02938 401614000322 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 401614000323 active site 401614000324 motif 3; other site 401614000325 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 401614000326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614000327 putative ADP-binding pocket [chemical binding]; other site 401614000328 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401614000329 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 401614000330 RNB domain; Region: RNB; pfam00773 401614000331 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 401614000332 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 401614000333 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 401614000334 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 401614000335 domain interfaces; other site 401614000336 active site 401614000337 CrcB-like protein; Region: CRCB; cl09114 401614000338 Zinc-finger domain; Region: zf-CHCC; cl01821 401614000339 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 401614000340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614000341 dimer interface [polypeptide binding]; other site 401614000342 conserved gate region; other site 401614000343 putative PBP binding loops; other site 401614000344 ABC-ATPase subunit interface; other site 401614000345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401614000346 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 401614000347 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 401614000348 Walker A/P-loop; other site 401614000349 ATP binding site [chemical binding]; other site 401614000350 Q-loop/lid; other site 401614000351 ABC transporter signature motif; other site 401614000352 Walker B; other site 401614000353 D-loop; other site 401614000354 H-loop/switch region; other site 401614000355 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 401614000356 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614000357 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 401614000358 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 401614000359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614000360 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 401614000361 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 401614000362 trimer interface [polypeptide binding]; other site 401614000363 putative metal binding site [ion binding]; other site 401614000364 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 401614000365 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 401614000366 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401614000367 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 401614000368 putative active site [active] 401614000369 Zn binding site [ion binding]; other site 401614000370 YGGT family; Region: YGGT; cl00508 401614000371 YGGT family; Region: YGGT; cl00508 401614000372 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 401614000373 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 401614000374 Walker A/P-loop; other site 401614000375 ATP binding site [chemical binding]; other site 401614000376 Q-loop/lid; other site 401614000377 ABC transporter signature motif; other site 401614000378 Walker B; other site 401614000379 D-loop; other site 401614000380 H-loop/switch region; other site 401614000381 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 401614000382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614000383 dimer interface [polypeptide binding]; other site 401614000384 conserved gate region; other site 401614000385 putative PBP binding loops; other site 401614000386 ABC-ATPase subunit interface; other site 401614000387 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 401614000388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401614000389 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 401614000390 Coenzyme A binding pocket [chemical binding]; other site 401614000391 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 401614000392 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 401614000393 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614000394 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 401614000395 Competence protein; Region: Competence; cl00471 401614000396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 401614000397 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 401614000398 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 401614000399 putative acyl-acceptor binding pocket; other site 401614000400 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 401614000401 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 401614000402 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 401614000403 RNA binding site [nucleotide binding]; other site 401614000404 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 401614000405 RNA binding site [nucleotide binding]; other site 401614000406 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 401614000407 RNA binding site [nucleotide binding]; other site 401614000408 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 401614000409 RNA binding site [nucleotide binding]; other site 401614000410 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 401614000411 RNA binding site [nucleotide binding]; other site 401614000412 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 401614000413 RNA binding site [nucleotide binding]; other site 401614000414 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 401614000415 nucleoside/Zn binding site; other site 401614000416 dimer interface [polypeptide binding]; other site 401614000417 catalytic motif [active] 401614000418 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 401614000419 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 401614000420 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614000421 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 401614000422 Cell division protein FtsQ; Region: FtsQ; pfam03799 401614000423 cell division protein FtsA; Region: ftsA; TIGR01174 401614000424 Cell division protein FtsA; Region: FtsA; cl11496 401614000425 Cell division protein FtsA; Region: FtsA; cl11496 401614000426 cell division protein FtsZ; Validated; Region: PRK09330 401614000427 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 401614000428 nucleotide binding site [chemical binding]; other site 401614000429 SulA interaction site; other site 401614000430 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 401614000431 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 401614000432 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 401614000433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614000434 Walker A motif; other site 401614000435 ATP binding site [chemical binding]; other site 401614000436 Walker B motif; other site 401614000437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614000438 arginine finger; other site 401614000439 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 401614000440 peptide chain release factor 2; Provisional; Region: PRK07342 401614000441 RF-1 domain; Region: RF-1; cl02875 401614000442 RF-1 domain; Region: RF-1; cl02875 401614000443 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 401614000444 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 401614000445 dimer interface [polypeptide binding]; other site 401614000446 putative anticodon binding site; other site 401614000447 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 401614000448 motif 1; other site 401614000449 active site 401614000450 motif 2; other site 401614000451 motif 3; other site 401614000452 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 401614000453 CAAX protease self-immunity; Region: Abi; cl00558 401614000454 Eps15 homology domain; Region: EH; smart00027 401614000455 Glutaminase; Region: Glutaminase; cl00907 401614000456 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614000457 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 401614000458 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 401614000459 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 401614000460 glutamine synthetase; Region: PLN02284 401614000461 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 401614000462 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 401614000463 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 401614000464 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 401614000465 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614000466 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614000467 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 401614000468 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 401614000469 purine monophosphate binding site [chemical binding]; other site 401614000470 dimer interface [polypeptide binding]; other site 401614000471 putative catalytic residues [active] 401614000472 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 401614000473 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 401614000474 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 401614000475 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 401614000476 GDP-binding site [chemical binding]; other site 401614000477 ACT binding site; other site 401614000478 IMP binding site; other site 401614000479 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614000480 active site 401614000481 Dienelactone hydrolase family; Region: DLH; pfam01738 401614000482 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 401614000483 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 401614000484 dimer interface [polypeptide binding]; other site 401614000485 putative PBP binding regions; other site 401614000486 ABC-ATPase subunit interface; other site 401614000487 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 401614000488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614000489 Walker A/P-loop; other site 401614000490 ATP binding site [chemical binding]; other site 401614000491 Q-loop/lid; other site 401614000492 ABC transporter signature motif; other site 401614000493 Walker B; other site 401614000494 D-loop; other site 401614000495 H-loop/switch region; other site 401614000496 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 401614000497 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 401614000498 intersubunit interface [polypeptide binding]; other site 401614000499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614000501 putative substrate translocation pore; other site 401614000502 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 401614000503 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 401614000504 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 401614000505 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 401614000506 primosome assembly protein PriA; Validated; Region: PRK05580 401614000507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614000508 ATP binding site [chemical binding]; other site 401614000509 putative Mg++ binding site [ion binding]; other site 401614000510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614000511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000512 putative substrate translocation pore; other site 401614000513 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401614000514 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401614000515 substrate binding pocket [chemical binding]; other site 401614000516 membrane-bound complex binding site; other site 401614000517 hinge residues; other site 401614000518 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 401614000519 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 401614000520 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 401614000521 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 401614000522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614000524 putative substrate translocation pore; other site 401614000525 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 401614000526 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 401614000527 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 401614000528 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 401614000529 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 401614000530 D-pathway; other site 401614000531 Putative ubiquinol binding site [chemical binding]; other site 401614000532 Low-spin heme (heme b) binding site [chemical binding]; other site 401614000533 Putative water exit pathway; other site 401614000534 Binuclear center (heme o3/CuB) [ion binding]; other site 401614000535 K-pathway; other site 401614000536 Putative proton exit pathway; other site 401614000537 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 401614000538 Subunit I/III interface [polypeptide binding]; other site 401614000539 Subunit III/IV interface [polypeptide binding]; other site 401614000540 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 401614000541 UbiA prenyltransferase family; Region: UbiA; cl00337 401614000542 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 401614000543 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 401614000544 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 401614000545 trimer interface [polypeptide binding]; other site 401614000546 active site 401614000547 UDP-GlcNAc binding site [chemical binding]; other site 401614000548 lipid binding site [chemical binding]; lipid-binding site 401614000549 TIGR01210 family protein; Region: TIGR01210 401614000550 pyridoxamine kinase; Validated; Region: PRK05756 401614000551 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 401614000552 dimer interface [polypeptide binding]; other site 401614000553 pyridoxal binding site [chemical binding]; other site 401614000554 ATP binding site [chemical binding]; other site 401614000555 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614000556 MoxR-like ATPases [General function prediction only]; Region: COG0714 401614000557 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614000558 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 401614000559 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 401614000560 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 401614000561 metal ion-dependent adhesion site (MIDAS); other site 401614000562 hypothetical protein; Provisional; Region: PRK13685 401614000563 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 401614000564 metal ion-dependent adhesion site (MIDAS); other site 401614000565 Tetratricopeptide repeat; Region: TPR_16; pfam13432 401614000566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 401614000567 Oxygen tolerance; Region: BatD; pfam13584 401614000568 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 401614000569 putative substrate binding pocket [chemical binding]; other site 401614000570 AC domain interface; other site 401614000571 catalytic triad [active] 401614000572 AB domain interface; other site 401614000573 interchain disulfide; other site 401614000574 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 401614000575 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 401614000576 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 401614000577 HIGH motif; other site 401614000578 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 401614000579 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 401614000580 active site 401614000581 KMSKS motif; other site 401614000582 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 401614000583 tRNA binding surface [nucleotide binding]; other site 401614000584 anticodon binding site; other site 401614000585 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 401614000586 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 401614000587 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 401614000588 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 401614000589 phosphate binding site [ion binding]; other site 401614000590 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 401614000591 dimer interface [polypeptide binding]; other site 401614000592 FMN binding site [chemical binding]; other site 401614000593 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 401614000594 nudix motif; other site 401614000595 fumarate hydratase; Reviewed; Region: fumC; PRK00485 401614000596 Class II fumarases; Region: Fumarase_classII; cd01362 401614000597 active site 401614000598 tetramer interface [polypeptide binding]; other site 401614000599 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 401614000600 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 401614000601 HIGH motif; other site 401614000602 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 401614000603 active site 401614000604 KMSKS motif; other site 401614000605 amino acid transporter; Region: 2A0306; TIGR00909 401614000606 Amidinotransferase; Region: Amidinotransf; cl12043 401614000607 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 401614000608 folate binding site [chemical binding]; other site 401614000609 NADP+ binding site [chemical binding]; other site 401614000610 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 401614000611 rRNA interaction site [nucleotide binding]; other site 401614000612 S8 interaction site; other site 401614000613 putative laminin-1 binding site; other site 401614000614 elongation factor Ts; Provisional; Region: tsf; PRK09377 401614000615 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 401614000616 Elongation factor TS; Region: EF_TS; pfam00889 401614000617 Elongation factor TS; Region: EF_TS; pfam00889 401614000618 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 401614000619 putative nucleotide binding site [chemical binding]; other site 401614000620 uridine monophosphate binding site [chemical binding]; other site 401614000621 homohexameric interface [polypeptide binding]; other site 401614000622 ribosome recycling factor; Reviewed; Region: frr; PRK00083 401614000623 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 401614000624 hinge region; other site 401614000625 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 401614000626 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 401614000627 catalytic residue [active] 401614000628 putative FPP diphosphate binding site; other site 401614000629 putative FPP binding hydrophobic cleft; other site 401614000630 dimer interface [polypeptide binding]; other site 401614000631 putative IPP diphosphate binding site; other site 401614000632 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 401614000633 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 401614000634 trimer interface [polypeptide binding]; other site 401614000635 active site 401614000636 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401614000637 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 401614000638 S17 interaction site [polypeptide binding]; other site 401614000639 S8 interaction site; other site 401614000640 16S rRNA interaction site [nucleotide binding]; other site 401614000641 streptomycin interaction site [chemical binding]; other site 401614000642 23S rRNA interaction site [nucleotide binding]; other site 401614000643 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 401614000644 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 401614000645 elongation factor G; Reviewed; Region: PRK00007 401614000646 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 401614000647 G1 box; other site 401614000648 putative GEF interaction site [polypeptide binding]; other site 401614000649 GTP/Mg2+ binding site [chemical binding]; other site 401614000650 Switch I region; other site 401614000651 G2 box; other site 401614000652 G3 box; other site 401614000653 Switch II region; other site 401614000654 G4 box; other site 401614000655 G5 box; other site 401614000656 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 401614000657 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 401614000658 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 401614000659 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 401614000660 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 401614000661 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 401614000662 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 401614000663 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 401614000664 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 401614000665 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 401614000666 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 401614000667 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 401614000668 putative translocon binding site; other site 401614000669 protein-rRNA interface [nucleotide binding]; other site 401614000670 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 401614000671 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 401614000672 G-X-X-G motif; other site 401614000673 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 401614000674 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 401614000675 23S rRNA interface [nucleotide binding]; other site 401614000676 5S rRNA interface [nucleotide binding]; other site 401614000677 putative antibiotic binding site [chemical binding]; other site 401614000678 L25 interface [polypeptide binding]; other site 401614000679 L27 interface [polypeptide binding]; other site 401614000680 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 401614000681 23S rRNA interface [nucleotide binding]; other site 401614000682 putative translocon interaction site; other site 401614000683 signal recognition particle (SRP54) interaction site; other site 401614000684 L23 interface [polypeptide binding]; other site 401614000685 trigger factor interaction site; other site 401614000686 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 401614000687 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 401614000688 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 401614000689 KOW motif; Region: KOW; cl00354 401614000690 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 401614000691 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 401614000692 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 401614000693 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 401614000694 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 401614000695 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 401614000696 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 401614000697 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 401614000698 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 401614000699 23S rRNA interface [nucleotide binding]; other site 401614000700 L21e interface [polypeptide binding]; other site 401614000701 5S rRNA interface [nucleotide binding]; other site 401614000702 L27 interface [polypeptide binding]; other site 401614000703 L5 interface [polypeptide binding]; other site 401614000704 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 401614000705 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 401614000706 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 401614000707 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 401614000708 23S rRNA binding site [nucleotide binding]; other site 401614000709 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 401614000710 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 401614000711 SecY translocase; Region: SecY; pfam00344 401614000712 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 401614000713 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 401614000714 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 401614000715 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 401614000716 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 401614000717 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 401614000718 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614000719 RNA binding surface [nucleotide binding]; other site 401614000720 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 401614000721 alphaNTD homodimer interface [polypeptide binding]; other site 401614000722 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 401614000723 alphaNTD - beta interaction site [polypeptide binding]; other site 401614000724 alphaNTD - beta' interaction site [polypeptide binding]; other site 401614000725 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 401614000726 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 401614000727 heat shock protein 90; Provisional; Region: PRK05218 401614000728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614000729 ATP binding site [chemical binding]; other site 401614000730 Mg2+ binding site [ion binding]; other site 401614000731 G-X-G motif; other site 401614000732 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 401614000733 CTP synthetase; Validated; Region: pyrG; PRK05380 401614000734 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 401614000735 Catalytic site [active] 401614000736 active site 401614000737 UTP binding site [chemical binding]; other site 401614000738 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 401614000739 active site 401614000740 putative oxyanion hole; other site 401614000741 catalytic triad [active] 401614000742 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 401614000743 active site 401614000744 multimer interface [polypeptide binding]; other site 401614000745 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 401614000746 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 401614000747 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 401614000748 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 401614000749 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 401614000750 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 401614000751 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 401614000752 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 401614000753 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 401614000754 ferredoxin-NADP reductase; Provisional; Region: PRK10926 401614000755 FAD binding pocket [chemical binding]; other site 401614000756 FAD binding motif [chemical binding]; other site 401614000757 phosphate binding motif [ion binding]; other site 401614000758 beta-alpha-beta structure motif; other site 401614000759 NAD binding pocket [chemical binding]; other site 401614000760 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 401614000761 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 401614000762 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 401614000763 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 401614000764 Fic/DOC family; Region: Fic; cl00960 401614000765 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614000766 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614000767 Transposase IS200 like; Region: Y1_Tnp; cl00848 401614000768 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 401614000769 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 401614000770 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 401614000771 Cation transport protein; Region: TrkH; cl10514 401614000772 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 401614000773 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 401614000774 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 401614000775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614000776 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 401614000777 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 401614000778 active site 401614000779 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 401614000780 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 401614000781 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 401614000782 putative active site [active] 401614000783 Sodium:solute symporter family; Region: SSF; cl00456 401614000784 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 401614000785 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 401614000786 DXD motif; other site 401614000787 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 401614000788 Domain of unknown function DUF21; Region: DUF21; pfam01595 401614000789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401614000790 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 401614000791 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 401614000792 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 401614000793 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 401614000794 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 401614000795 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 401614000796 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 401614000797 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 401614000798 active site 401614000799 HIGH motif; other site 401614000800 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 401614000801 KMSKS motif; other site 401614000802 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 401614000803 tRNA binding surface [nucleotide binding]; other site 401614000804 anticodon binding site; other site 401614000805 HemK family putative methylases; Region: hemK_fam; TIGR00536 401614000806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614000807 S-adenosylmethionine binding site [chemical binding]; other site 401614000808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614000810 putative substrate translocation pore; other site 401614000811 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 401614000812 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 401614000813 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 401614000814 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 401614000815 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 401614000816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 401614000817 active site 401614000818 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614000819 dimer interface [polypeptide binding]; other site 401614000820 substrate binding site [chemical binding]; other site 401614000821 catalytic residues [active] 401614000822 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614000823 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 401614000824 Spore germination protein; Region: Spore_permease; cl15802 401614000825 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614000826 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 401614000827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614000828 VacJ like lipoprotein; Region: VacJ; cl01073 401614000829 BolA-like protein; Region: BolA; cl00386 401614000830 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 401614000831 anti sigma factor interaction site; other site 401614000832 regulatory phosphorylation site [posttranslational modification]; other site 401614000833 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 401614000834 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 401614000835 mce related protein; Region: MCE; pfam02470 401614000836 Permease; Region: Permease; cl00510 401614000837 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 401614000838 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 401614000839 Walker A/P-loop; other site 401614000840 ATP binding site [chemical binding]; other site 401614000841 Q-loop/lid; other site 401614000842 ABC transporter signature motif; other site 401614000843 Walker B; other site 401614000844 D-loop; other site 401614000845 H-loop/switch region; other site 401614000846 Septum formation topological specificity factor MinE; Region: MinE; cl00538 401614000847 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 401614000848 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 401614000849 Switch I; other site 401614000850 Switch II; other site 401614000851 septum formation inhibitor; Reviewed; Region: minC; PRK04804 401614000852 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 401614000853 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 401614000854 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 401614000855 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 401614000856 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 401614000857 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 401614000858 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 401614000859 ssDNA binding site; other site 401614000860 generic binding surface II; other site 401614000861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614000862 ATP binding site [chemical binding]; other site 401614000863 putative Mg++ binding site [ion binding]; other site 401614000864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614000865 nucleotide binding region [chemical binding]; other site 401614000866 ATP-binding site [chemical binding]; other site 401614000867 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 401614000868 Fumarase C-terminus; Region: Fumerase_C; cl00795 401614000869 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 401614000870 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 401614000871 nudix motif; other site 401614000872 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 401614000873 ArsC family; Region: ArsC; pfam03960 401614000874 catalytic residue [active] 401614000875 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 401614000876 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 401614000877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614000878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614000879 homodimer interface [polypeptide binding]; other site 401614000880 catalytic residue [active] 401614000881 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 401614000882 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 401614000883 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 401614000884 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 401614000885 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 401614000886 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 401614000887 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 401614000888 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 401614000889 ligand binding site [chemical binding]; other site 401614000890 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 401614000891 LytB protein; Region: LYTB; cl00507 401614000892 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 401614000893 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 401614000894 homotrimer interaction site [polypeptide binding]; other site 401614000895 active site 401614000896 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401614000897 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 401614000898 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 401614000899 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 401614000900 TolB amino-terminal domain; Region: TolB_N; cl00639 401614000901 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 401614000902 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 401614000903 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 401614000904 ligand binding site [chemical binding]; other site 401614000905 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 401614000906 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 401614000907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614000908 FeS/SAM binding site; other site 401614000909 TRAM domain; Region: TRAM; cl01282 401614000910 short chain dehydrogenase; Provisional; Region: PRK06924 401614000911 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 401614000912 NADP binding site [chemical binding]; other site 401614000913 homodimer interface [polypeptide binding]; other site 401614000914 active site 401614000915 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 401614000916 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 401614000917 DNA photolyase; Region: DNA_photolyase; pfam00875 401614000918 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 401614000919 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 401614000920 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 401614000921 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 401614000922 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 401614000923 Membrane transport protein; Region: Mem_trans; cl09117 401614000924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 401614000925 YheO-like PAS domain; Region: PAS_6; pfam08348 401614000926 Helix-turn-helix domains; Region: HTH; cl00088 401614000927 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 401614000928 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401614000929 integrase; Provisional; Region: PRK09692 401614000930 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 401614000931 active site 401614000932 Int/Topo IB signature motif; other site 401614000933 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 401614000934 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 401614000935 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 401614000936 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 401614000937 active site 401614000938 Int/Topo IB signature motif; other site 401614000939 Helix-turn-helix domain; Region: HTH_39; pfam14090 401614000940 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 401614000941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401614000942 non-specific DNA binding site [nucleotide binding]; other site 401614000943 salt bridge; other site 401614000944 sequence-specific DNA binding site [nucleotide binding]; other site 401614000945 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 401614000946 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 401614000947 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 401614000948 transmembrane helices; other site 401614000949 Protein of unknown function (DUF423); Region: DUF423; cl01008 401614000950 Protein of unknown function, DUF393; Region: DUF393; cl01136 401614000951 UbiA prenyltransferase family; Region: UbiA; cl00337 401614000952 UTRA domain; Region: UTRA; cl01230 401614000953 ribonuclease PH; Reviewed; Region: rph; PRK00173 401614000954 Ribonuclease PH; Region: RNase_PH_bact; cd11362 401614000955 hexamer interface [polypeptide binding]; other site 401614000956 active site 401614000957 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 401614000958 Peptidase family M48; Region: Peptidase_M48; cl12018 401614000959 LemA family; Region: LemA; cl00742 401614000960 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 401614000961 Helix-turn-helix domains; Region: HTH; cl00088 401614000962 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 401614000963 putative dimerization interface [polypeptide binding]; other site 401614000964 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 401614000965 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 401614000966 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401614000967 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614000968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614000969 dimerization interface [polypeptide binding]; other site 401614000970 putative DNA binding site [nucleotide binding]; other site 401614000971 putative Zn2+ binding site [ion binding]; other site 401614000972 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 401614000973 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 401614000974 putative active site [active] 401614000975 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 401614000976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614000977 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 401614000978 Colicin V production protein; Region: Colicin_V; cl00567 401614000979 DNA repair protein RadA; Provisional; Region: PRK11823 401614000980 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 401614000981 Walker A motif/ATP binding site; other site 401614000982 ATP binding site [chemical binding]; other site 401614000983 Walker B motif; other site 401614000984 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 401614000985 PilZ domain; Region: PilZ; cl01260 401614000986 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401614000987 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 401614000988 Tetramer interface [polypeptide binding]; other site 401614000989 active site 401614000990 FMN-binding site [chemical binding]; other site 401614000991 PQ loop repeat; Region: PQ-loop; cl12056 401614000992 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 401614000993 SelR domain; Region: SelR; pfam01641 401614000994 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 401614000995 E-class dimer interface [polypeptide binding]; other site 401614000996 P-class dimer interface [polypeptide binding]; other site 401614000997 active site 401614000998 Cu2+ binding site [ion binding]; other site 401614000999 Zn2+ binding site [ion binding]; other site 401614001000 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 401614001001 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 401614001002 Cupin domain; Region: Cupin_2; cl09118 401614001003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001004 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 401614001005 NAD(P) binding site [chemical binding]; other site 401614001006 aspartate aminotransferase; Provisional; Region: PRK07568 401614001007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614001008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001009 homodimer interface [polypeptide binding]; other site 401614001010 catalytic residue [active] 401614001011 Cation efflux family; Region: Cation_efflux; cl00316 401614001012 recombination and repair protein; Provisional; Region: PRK10869 401614001013 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 401614001014 Walker A/P-loop; other site 401614001015 ATP binding site [chemical binding]; other site 401614001016 Q-loop/lid; other site 401614001017 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 401614001018 ABC transporter signature motif; other site 401614001019 Walker B; other site 401614001020 D-loop; other site 401614001021 H-loop/switch region; other site 401614001022 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 401614001023 Pilin (bacterial filament); Region: Pilin; pfam00114 401614001024 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 401614001025 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 401614001026 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 401614001027 Pilin (bacterial filament); Region: Pilin; pfam00114 401614001028 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 401614001029 active site 401614001030 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 401614001031 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 401614001032 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 401614001033 homodimer interface [polypeptide binding]; other site 401614001034 NADP binding site [chemical binding]; other site 401614001035 substrate binding site [chemical binding]; other site 401614001036 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 401614001037 GIY-YIG motif/motif A; other site 401614001038 putative active site [active] 401614001039 putative metal binding site [ion binding]; other site 401614001040 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 401614001041 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 401614001042 dimerization interface [polypeptide binding]; other site 401614001043 putative ATP binding site [chemical binding]; other site 401614001044 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 401614001045 active site 401614001046 ATP binding site [chemical binding]; other site 401614001047 substrate binding site [chemical binding]; other site 401614001048 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 401614001049 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 401614001050 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614001051 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 401614001052 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 401614001053 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 401614001054 active site 401614001055 substrate binding site [chemical binding]; other site 401614001056 cosubstrate binding site; other site 401614001057 catalytic site [active] 401614001058 AIR carboxylase; Region: AIRC; cl00310 401614001059 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 401614001060 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614001061 Restriction endonuclease; Region: Mrr_cat; cl00516 401614001062 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 401614001063 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 401614001064 active site 401614001065 Zn binding site [ion binding]; other site 401614001066 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 401614001067 O-Antigen ligase; Region: Wzy_C; cl04850 401614001068 DNA topoisomerase I; Validated; Region: PRK06599 401614001069 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 401614001070 active site 401614001071 interdomain interaction site; other site 401614001072 putative metal-binding site [ion binding]; other site 401614001073 nucleotide binding site [chemical binding]; other site 401614001074 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 401614001075 domain I; other site 401614001076 DNA binding groove [nucleotide binding] 401614001077 phosphate binding site [ion binding]; other site 401614001078 domain II; other site 401614001079 domain III; other site 401614001080 nucleotide binding site [chemical binding]; other site 401614001081 catalytic site [active] 401614001082 domain IV; other site 401614001083 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 401614001084 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 401614001085 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 401614001086 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 401614001087 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 401614001088 P-loop; other site 401614001089 Magnesium ion binding site [ion binding]; other site 401614001090 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 401614001091 ParB-like nuclease domain; Region: ParBc; cl02129 401614001092 KorB domain; Region: KorB; pfam08535 401614001093 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 401614001094 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 401614001095 catalytic triad [active] 401614001096 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 401614001097 active site 401614001098 catalytic triad [active] 401614001099 oxyanion hole [active] 401614001100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 401614001101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614001102 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 401614001103 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 401614001104 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 401614001105 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401614001106 active site 401614001107 HIGH motif; other site 401614001108 nucleotide binding site [chemical binding]; other site 401614001109 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 401614001110 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 401614001111 active site 401614001112 KMSKS motif; other site 401614001113 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 401614001114 tRNA binding surface [nucleotide binding]; other site 401614001115 anticodon binding site; other site 401614001116 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 401614001117 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 401614001118 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 401614001119 active site 401614001120 Riboflavin kinase; Region: Flavokinase; cl03312 401614001121 malate dehydrogenase; Provisional; Region: PRK13529 401614001122 Malic enzyme, N-terminal domain; Region: malic; pfam00390 401614001123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001124 NAD(P) binding pocket [chemical binding]; other site 401614001125 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614001126 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614001127 GTP-binding protein Der; Reviewed; Region: PRK00093 401614001128 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 401614001129 G1 box; other site 401614001130 GTP/Mg2+ binding site [chemical binding]; other site 401614001131 Switch I region; other site 401614001132 G2 box; other site 401614001133 Switch II region; other site 401614001134 G3 box; other site 401614001135 G4 box; other site 401614001136 G5 box; other site 401614001137 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 401614001138 G1 box; other site 401614001139 GTP/Mg2+ binding site [chemical binding]; other site 401614001140 Switch I region; other site 401614001141 G2 box; other site 401614001142 G3 box; other site 401614001143 Switch II region; other site 401614001144 G4 box; other site 401614001145 G5 box; other site 401614001146 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 401614001147 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 401614001148 putative active site [active] 401614001149 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 401614001150 FAD binding domain; Region: FAD_binding_4; pfam01565 401614001151 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 401614001152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614001153 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 401614001154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 401614001155 PAS fold; Region: PAS_3; pfam08447 401614001156 putative active site [active] 401614001157 heme pocket [chemical binding]; other site 401614001158 PAS fold; Region: PAS_4; pfam08448 401614001159 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 401614001160 metal binding site [ion binding]; metal-binding site 401614001161 active site 401614001162 I-site; other site 401614001163 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 401614001164 Domain of unknown function (DUF814); Region: DUF814; pfam05670 401614001165 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401614001166 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 401614001167 DXD motif; other site 401614001168 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 401614001169 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614001170 CheB methylesterase; Region: CheB_methylest; pfam01339 401614001171 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 401614001172 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 401614001173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001174 IncA protein; Region: IncA; pfam04156 401614001175 bZIP transcription factor; Region: bZIP_1; cl02576 401614001176 PAS domain; Region: PAS_10; pfam13596 401614001177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 401614001178 PAS domain; Region: PAS_9; pfam13426 401614001179 putative active site [active] 401614001180 heme pocket [chemical binding]; other site 401614001181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 401614001182 metal binding site [ion binding]; metal-binding site 401614001183 active site 401614001184 I-site; other site 401614001185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 401614001186 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 401614001187 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614001188 active site 401614001189 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 401614001190 nucleotide binding site/active site [active] 401614001191 HIT family signature motif; other site 401614001192 catalytic residue [active] 401614001193 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 401614001194 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401614001195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 401614001196 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 401614001197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614001198 S-adenosylmethionine binding site [chemical binding]; other site 401614001199 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 401614001200 glucokinase, proteobacterial type; Region: glk; TIGR00749 401614001201 Intracellular septation protein A; Region: IspA; cl01098 401614001202 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 401614001203 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 401614001204 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 401614001205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001206 D-galactonate transporter; Region: 2A0114; TIGR00893 401614001207 putative substrate translocation pore; other site 401614001208 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 401614001209 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 401614001210 active site 401614001211 HIGH motif; other site 401614001212 KMSKS motif; other site 401614001213 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 401614001214 tRNA binding surface [nucleotide binding]; other site 401614001215 anticodon binding site; other site 401614001216 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 401614001217 dimer interface [polypeptide binding]; other site 401614001218 putative tRNA-binding site [nucleotide binding]; other site 401614001219 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 401614001220 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 401614001221 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 401614001222 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 401614001223 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 401614001224 active site 401614001225 putative substrate binding region [chemical binding]; other site 401614001226 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 401614001227 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 401614001228 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 401614001229 active site 401614001230 (T/H)XGH motif; other site 401614001231 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 401614001232 nudix motif; other site 401614001233 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 401614001234 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 401614001235 Substrate binding site; other site 401614001236 Mg++ binding site; other site 401614001237 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 401614001238 active site 401614001239 substrate binding site [chemical binding]; other site 401614001240 CoA binding site [chemical binding]; other site 401614001241 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 401614001242 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 401614001243 glutaminase active site [active] 401614001244 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 401614001245 dimer interface [polypeptide binding]; other site 401614001246 active site 401614001247 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 401614001248 dimer interface [polypeptide binding]; other site 401614001249 active site 401614001250 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 401614001251 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 401614001252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 401614001253 DNA-binding site [nucleotide binding]; DNA binding site 401614001254 RNA-binding motif; other site 401614001255 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 401614001256 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 401614001257 active site 401614001258 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 401614001259 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 401614001260 CAP-like domain; other site 401614001261 active site 401614001262 primary dimer interface [polypeptide binding]; other site 401614001263 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401614001264 BNR repeat-like domain; Region: BNR_2; pfam13088 401614001265 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 401614001266 catalytic site [active] 401614001267 Asp-box motif; other site 401614001268 lytic murein transglycosylase; Provisional; Region: PRK11619 401614001269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 401614001270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401614001271 catalytic residue [active] 401614001272 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 401614001273 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 401614001274 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 401614001275 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 401614001276 generic binding surface II; other site 401614001277 generic binding surface I; other site 401614001278 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 401614001279 active site 401614001280 catalytic residues [active] 401614001281 metal binding site [ion binding]; metal-binding site 401614001282 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 401614001283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401614001284 FtsX-like permease family; Region: FtsX; cl15850 401614001285 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 401614001286 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 401614001287 Walker A/P-loop; other site 401614001288 ATP binding site [chemical binding]; other site 401614001289 Q-loop/lid; other site 401614001290 ABC transporter signature motif; other site 401614001291 Walker B; other site 401614001292 D-loop; other site 401614001293 H-loop/switch region; other site 401614001294 lysine decarboxylase LdcC; Provisional; Region: PRK15399 401614001295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 401614001296 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 401614001297 homodimer interface [polypeptide binding]; other site 401614001298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001299 catalytic residue [active] 401614001300 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 401614001301 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 401614001302 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 401614001303 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 401614001304 lipoyl attachment site [posttranslational modification]; other site 401614001305 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 401614001306 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 401614001307 tetramer interface [polypeptide binding]; other site 401614001308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001309 catalytic residue [active] 401614001310 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 401614001311 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 401614001312 tetramer interface [polypeptide binding]; other site 401614001313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001314 catalytic residue [active] 401614001315 Predicted helicase [General function prediction only]; Region: COG4889 401614001316 Predicted helicase [General function prediction only]; Region: COG4889 401614001317 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 401614001318 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 401614001319 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 401614001320 shikimate binding site; other site 401614001321 NAD(P) binding site [chemical binding]; other site 401614001322 pullulanase, type I; Region: pulA_typeI; TIGR02104 401614001323 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 401614001324 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 401614001325 Ca binding site [ion binding]; other site 401614001326 active site 401614001327 catalytic site [active] 401614001328 glycogen branching enzyme; Provisional; Region: PRK12313 401614001329 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 401614001330 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 401614001331 active site 401614001332 catalytic site [active] 401614001333 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 401614001334 phosphoglucomutase; Region: PLN02307 401614001335 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 401614001336 substrate binding site [chemical binding]; other site 401614001337 dimer interface [polypeptide binding]; other site 401614001338 active site 401614001339 metal binding site [ion binding]; metal-binding site 401614001340 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 401614001341 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 401614001342 ligand binding site; other site 401614001343 oligomer interface; other site 401614001344 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 401614001345 dimer interface [polypeptide binding]; other site 401614001346 N-terminal domain interface [polypeptide binding]; other site 401614001347 sulfate 1 binding site; other site 401614001348 glycogen synthase; Provisional; Region: glgA; PRK00654 401614001349 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 401614001350 ADP-binding pocket [chemical binding]; other site 401614001351 homodimer interface [polypeptide binding]; other site 401614001352 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401614001353 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 401614001354 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 401614001355 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 401614001356 dimer interface [polypeptide binding]; other site 401614001357 motif 1; other site 401614001358 active site 401614001359 motif 2; other site 401614001360 motif 3; other site 401614001361 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 401614001362 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614001363 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001364 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614001365 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 401614001366 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614001367 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 401614001368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001369 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 401614001370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001371 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 401614001372 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 401614001373 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 401614001374 nucleotide binding site [chemical binding]; other site 401614001375 substrate binding site [chemical binding]; other site 401614001376 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 401614001377 dimer interface [polypeptide binding]; other site 401614001378 putative threonine allosteric regulatory site; other site 401614001379 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 401614001380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001381 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 401614001382 homoserine kinase; Provisional; Region: PRK01212 401614001383 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401614001384 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 401614001385 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 401614001386 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 401614001387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614001388 catalytic residue [active] 401614001389 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 401614001390 putative active site [active] 401614001391 putative metal binding site [ion binding]; other site 401614001392 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 401614001393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614001394 active site 401614001395 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 401614001396 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614001397 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001398 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614001399 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 401614001400 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 401614001401 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 401614001402 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 401614001403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001404 putative substrate translocation pore; other site 401614001405 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 401614001406 Predicted membrane protein [Function unknown]; Region: COG4129 401614001407 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 401614001408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001409 putative substrate translocation pore; other site 401614001410 ABC transporter ATPase component; Reviewed; Region: PRK11147 401614001411 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 401614001412 Walker A/P-loop; other site 401614001413 ATP binding site [chemical binding]; other site 401614001414 Q-loop/lid; other site 401614001415 ABC transporter signature motif; other site 401614001416 Walker B; other site 401614001417 D-loop; other site 401614001418 H-loop/switch region; other site 401614001419 ABC transporter; Region: ABC_tran_2; pfam12848 401614001420 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 401614001421 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614001422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614001423 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 401614001424 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 401614001425 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 401614001426 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401614001427 active site 401614001428 HIGH motif; other site 401614001429 nucleotide binding site [chemical binding]; other site 401614001430 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 401614001431 KMSKS motif; other site 401614001432 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 401614001433 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 401614001434 active site 401614001435 metal-binding site [ion binding] 401614001436 nucleotide-binding site [chemical binding]; other site 401614001437 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 401614001438 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 401614001439 Mg++ binding site [ion binding]; other site 401614001440 putative catalytic motif [active] 401614001441 putative substrate binding site [chemical binding]; other site 401614001442 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 401614001443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614001445 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 401614001446 YdjC-like protein; Region: YdjC; cl01344 401614001447 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 401614001448 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 401614001449 Ligand binding site; other site 401614001450 Putative Catalytic site; other site 401614001451 DXD motif; other site 401614001452 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 401614001453 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 401614001454 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 401614001455 DsrC like protein; Region: DsrC; cl01101 401614001456 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614001457 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 401614001458 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 401614001459 dimer interface [polypeptide binding]; other site 401614001460 N-terminal domain interface [polypeptide binding]; other site 401614001461 putative inner membrane peptidase; Provisional; Region: PRK11778 401614001462 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 401614001463 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 401614001464 tandem repeat interface [polypeptide binding]; other site 401614001465 oligomer interface [polypeptide binding]; other site 401614001466 active site residues [active] 401614001467 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 401614001468 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614001469 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 401614001470 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 401614001471 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 401614001472 dimer interface [polypeptide binding]; other site 401614001473 active site 401614001474 Schiff base residues; other site 401614001475 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 401614001476 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 401614001477 active site 401614001478 homotetramer interface [polypeptide binding]; other site 401614001479 homodimer interface [polypeptide binding]; other site 401614001480 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 401614001481 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 401614001482 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401614001483 active site 401614001484 HIGH motif; other site 401614001485 nucleotide binding site [chemical binding]; other site 401614001486 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 401614001487 KMSK motif region; other site 401614001488 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 401614001489 tRNA binding surface [nucleotide binding]; other site 401614001490 anticodon binding site; other site 401614001491 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 401614001492 Organic solvent tolerance protein; Region: OstA_C; pfam04453 401614001493 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 401614001494 SurA N-terminal domain; Region: SurA_N_3; cl07813 401614001495 PPIC-type PPIASE domain; Region: Rotamase; cl08278 401614001496 PPIC-type PPIASE domain; Region: Rotamase; cl08278 401614001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001498 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 401614001499 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 401614001500 active site 401614001501 metal binding site [ion binding]; metal-binding site 401614001502 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 401614001503 trimer interface [polypeptide binding]; other site 401614001504 active site 401614001505 dimer interface [polypeptide binding]; other site 401614001506 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 401614001507 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 401614001508 carboxyltransferase (CT) interaction site; other site 401614001509 biotinylation site [posttranslational modification]; other site 401614001510 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 401614001511 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614001512 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614001513 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 401614001514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 401614001515 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 401614001516 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614001517 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 401614001518 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 401614001519 motif 1; other site 401614001520 dimer interface [polypeptide binding]; other site 401614001521 active site 401614001522 motif 2; other site 401614001523 motif 3; other site 401614001524 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 401614001525 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 401614001526 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 401614001527 DHH family; Region: DHH; pfam01368 401614001528 DHHA1 domain; Region: DHHA1; pfam02272 401614001529 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 401614001530 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614001531 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 401614001532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614001533 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614001534 GTPase RsgA; Reviewed; Region: PRK00098 401614001535 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614001536 RNA binding site [nucleotide binding]; other site 401614001537 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 401614001538 GTPase/Zn-binding domain interface [polypeptide binding]; other site 401614001539 GTP/Mg2+ binding site [chemical binding]; other site 401614001540 G4 box; other site 401614001541 G5 box; other site 401614001542 G1 box; other site 401614001543 Switch I region; other site 401614001544 G2 box; other site 401614001545 G3 box; other site 401614001546 Switch II region; other site 401614001547 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 401614001548 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 401614001549 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 401614001550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614001551 ATP binding site [chemical binding]; other site 401614001552 Mg2+ binding site [ion binding]; other site 401614001553 G-X-G motif; other site 401614001554 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 401614001555 ATP binding site [chemical binding]; other site 401614001556 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 401614001557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001559 putative substrate translocation pore; other site 401614001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001562 putative substrate translocation pore; other site 401614001563 thioredoxin reductase; Provisional; Region: PRK10262 401614001564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614001565 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 401614001566 PLD-like domain; Region: PLDc_2; pfam13091 401614001567 putative active site [active] 401614001568 catalytic site [active] 401614001569 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 401614001570 PLD-like domain; Region: PLDc_2; pfam13091 401614001571 putative active site [active] 401614001572 putative catalytic site [active] 401614001573 phosphoglycolate phosphatase; Provisional; Region: PRK13222 401614001574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614001575 motif II; other site 401614001576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614001577 Helix-turn-helix domains; Region: HTH; cl00088 401614001578 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614001579 putative effector binding pocket; other site 401614001580 dimerization interface [polypeptide binding]; other site 401614001581 MFS transport protein AraJ; Provisional; Region: PRK10091 401614001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001583 putative substrate translocation pore; other site 401614001584 CutC family; Region: CutC; cl01218 401614001585 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 401614001586 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 401614001587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 401614001588 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 401614001589 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 401614001590 active site 401614001591 dimer interface [polypeptide binding]; other site 401614001592 catalytic nucleophile [active] 401614001593 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614001594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614001595 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614001596 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 401614001597 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 401614001598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001599 CoA-ligase; Region: Ligase_CoA; cl02894 401614001600 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 401614001601 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614001602 CoA-ligase; Region: Ligase_CoA; cl02894 401614001603 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 401614001604 TIGR03545 family protein; Region: TIGR03545 401614001605 TIGR03545 family protein; Region: TIGR03545 401614001606 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614001607 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 401614001608 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 401614001609 FMN binding site [chemical binding]; other site 401614001610 active site 401614001611 catalytic residues [active] 401614001612 substrate binding site [chemical binding]; other site 401614001613 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 401614001614 putative active site pocket [active] 401614001615 dimerization interface [polypeptide binding]; other site 401614001616 putative catalytic residue [active] 401614001617 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 401614001618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614001619 Mg2+ binding site [ion binding]; other site 401614001620 G-X-G motif; other site 401614001621 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 401614001622 anchoring element; other site 401614001623 dimer interface [polypeptide binding]; other site 401614001624 ATP binding site [chemical binding]; other site 401614001625 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 401614001626 active site 401614001627 putative metal-binding site [ion binding]; other site 401614001628 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 401614001629 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 401614001630 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 401614001631 active site 401614001632 multimer interface [polypeptide binding]; other site 401614001633 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 401614001634 predicted active site [active] 401614001635 catalytic triad [active] 401614001636 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 401614001637 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 401614001638 DNA binding site [nucleotide binding] 401614001639 catalytic residue [active] 401614001640 H2TH interface [polypeptide binding]; other site 401614001641 putative catalytic residues [active] 401614001642 turnover-facilitating residue; other site 401614001643 intercalation triad [nucleotide binding]; other site 401614001644 8OG recognition residue [nucleotide binding]; other site 401614001645 putative reading head residues; other site 401614001646 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 401614001647 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 401614001648 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 401614001649 AMP-binding enzyme; Region: AMP-binding; cl15778 401614001650 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 401614001651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001652 Septum formation initiator; Region: DivIC; cl11433 401614001653 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 401614001654 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 401614001655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 401614001656 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 401614001657 16S/18S rRNA binding site [nucleotide binding]; other site 401614001658 S13e-L30e interaction site [polypeptide binding]; other site 401614001659 25S rRNA binding site [nucleotide binding]; other site 401614001660 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 401614001661 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 401614001662 oligomer interface [polypeptide binding]; other site 401614001663 RNA binding site [nucleotide binding]; other site 401614001664 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 401614001665 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 401614001666 RNase E interface [polypeptide binding]; other site 401614001667 trimer interface [polypeptide binding]; other site 401614001668 active site 401614001669 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 401614001670 putative nucleic acid binding region [nucleotide binding]; other site 401614001671 G-X-X-G motif; other site 401614001672 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614001673 RNA binding site [nucleotide binding]; other site 401614001674 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 401614001675 NeuB family; Region: NeuB; cl00496 401614001676 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 401614001677 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 401614001678 ATP-binding site [chemical binding]; other site 401614001679 Sugar specificity; other site 401614001680 Pyrimidine base specificity; other site 401614001681 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 401614001682 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 401614001683 TRAM domain; Region: TRAM; cl01282 401614001684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614001685 S-adenosylmethionine binding site [chemical binding]; other site 401614001686 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614001687 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 401614001688 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614001689 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 401614001690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001692 putative substrate translocation pore; other site 401614001693 enolase; Provisional; Region: eno; PRK00077 401614001694 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 401614001695 dimer interface [polypeptide binding]; other site 401614001696 metal binding site [ion binding]; metal-binding site 401614001697 substrate binding pocket [chemical binding]; other site 401614001698 Septum formation initiator; Region: DivIC; cl11433 401614001699 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 401614001700 substrate binding site; other site 401614001701 dimer interface; other site 401614001702 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614001703 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614001704 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 401614001705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001706 NAD(P) binding site [chemical binding]; other site 401614001707 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 401614001708 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 401614001709 substrate-cofactor binding pocket; other site 401614001710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001711 catalytic residue [active] 401614001712 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 401614001713 Glyco_18 domain; Region: Glyco_18; smart00636 401614001714 active site 401614001715 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 401614001716 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 401614001717 chitin/cellulose binding site [chemical binding]; other site 401614001718 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 401614001719 chitin/cellulose binding site [chemical binding]; other site 401614001720 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 401614001721 chitin/cellulose binding site [chemical binding]; other site 401614001722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614001723 active site 401614001724 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 401614001725 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 401614001726 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 401614001727 putative active site [active] 401614001728 putative substrate binding site [chemical binding]; other site 401614001729 putative cosubstrate binding site; other site 401614001730 catalytic site [active] 401614001731 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 401614001732 putative substrate binding pocket [chemical binding]; other site 401614001733 trimer interface [polypeptide binding]; other site 401614001734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001735 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614001736 putative substrate translocation pore; other site 401614001737 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 401614001738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 401614001739 Zn2+ binding site [ion binding]; other site 401614001740 Mg2+ binding site [ion binding]; other site 401614001741 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 401614001742 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 401614001743 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 401614001744 heme binding site [chemical binding]; other site 401614001745 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 401614001746 classical (c) SDRs; Region: SDR_c; cd05233 401614001747 NAD(P) binding site [chemical binding]; other site 401614001748 active site 401614001749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 401614001750 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 401614001751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001752 putative substrate translocation pore; other site 401614001753 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 401614001754 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 401614001755 active site 401614001756 catalytic site [active] 401614001757 metal binding site [ion binding]; metal-binding site 401614001758 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 401614001759 Sulfate transporter family; Region: Sulfate_transp; cl15842 401614001760 Sulfate transporter family; Region: Sulfate_transp; cl15842 401614001761 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 401614001762 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 401614001763 homotrimer interaction site [polypeptide binding]; other site 401614001764 putative active site [active] 401614001765 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 401614001766 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 401614001767 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 401614001768 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 401614001769 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614001770 Walker A/P-loop; other site 401614001771 ATP binding site [chemical binding]; other site 401614001772 Q-loop/lid; other site 401614001773 ABC transporter signature motif; other site 401614001774 Walker B; other site 401614001775 D-loop; other site 401614001776 H-loop/switch region; other site 401614001777 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 401614001778 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614001779 Walker A/P-loop; other site 401614001780 ATP binding site [chemical binding]; other site 401614001781 Q-loop/lid; other site 401614001782 ABC transporter signature motif; other site 401614001783 Walker B; other site 401614001784 D-loop; other site 401614001785 H-loop/switch region; other site 401614001786 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 401614001787 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614001788 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 401614001789 seryl-tRNA synthetase; Provisional; Region: PRK05431 401614001790 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 401614001791 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 401614001792 dimer interface [polypeptide binding]; other site 401614001793 active site 401614001794 motif 1; other site 401614001795 motif 2; other site 401614001796 motif 3; other site 401614001797 Sulfatase; Region: Sulfatase; cl10460 401614001798 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 401614001799 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614001800 FAD binding domain; Region: FAD_binding_4; pfam01565 401614001801 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 401614001802 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 401614001803 active site 401614001804 catalytic motif [active] 401614001805 Zn binding site [ion binding]; other site 401614001806 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 401614001807 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401614001808 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 401614001809 active site 401614001810 dinuclear metal binding site [ion binding]; other site 401614001811 dimerization interface [polypeptide binding]; other site 401614001812 Predicted membrane protein [Function unknown]; Region: COG2860 401614001813 UPF0126 domain; Region: UPF0126; pfam03458 401614001814 UPF0126 domain; Region: UPF0126; pfam03458 401614001815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614001816 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 401614001817 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 401614001818 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 401614001819 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 401614001820 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 401614001821 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 401614001822 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 401614001823 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 401614001824 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 401614001825 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 401614001826 multifunctional aminopeptidase A; Provisional; Region: PRK00913 401614001827 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 401614001828 interface (dimer of trimers) [polypeptide binding]; other site 401614001829 Substrate-binding/catalytic site; other site 401614001830 Zn-binding sites [ion binding]; other site 401614001831 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 401614001832 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 401614001833 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 401614001834 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 401614001835 active site 401614001836 Thiamine pyrophosphokinase; Region: TPK; cd07995 401614001837 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 401614001838 active site 401614001839 dimerization interface [polypeptide binding]; other site 401614001840 thiamine binding site [chemical binding]; other site 401614001841 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 401614001842 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 401614001843 active site 401614001844 dimer interface [polypeptide binding]; other site 401614001845 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 401614001846 dimer interface [polypeptide binding]; other site 401614001847 active site 401614001848 Type II transport protein GspH; Region: GspH; pfam12019 401614001849 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 401614001850 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 401614001851 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 401614001852 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 401614001853 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 401614001854 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 401614001855 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 401614001856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001857 putative transporter; Provisional; Region: PRK10504 401614001858 putative substrate translocation pore; other site 401614001859 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 401614001860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614001861 Walker A motif; other site 401614001862 ATP binding site [chemical binding]; other site 401614001863 Walker B motif; other site 401614001864 arginine finger; other site 401614001865 Peptidase family M41; Region: Peptidase_M41; pfam01434 401614001866 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401614001867 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 401614001868 LPP20 lipoprotein; Region: LPP20; cl15824 401614001869 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 401614001870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614001871 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 401614001872 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614001873 nucleotide binding region [chemical binding]; other site 401614001874 ATP-binding site [chemical binding]; other site 401614001875 hypothetical protein; Provisional; Region: PRK05590 401614001876 SEC-C motif; Region: SEC-C; pfam02810 401614001877 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 401614001878 Glycerate kinase family; Region: Gly_kinase; cl00841 401614001879 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 401614001880 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 401614001881 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 401614001882 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614001883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001884 putative substrate translocation pore; other site 401614001885 ribonuclease D; Region: rnd; TIGR01388 401614001886 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 401614001887 putative active site [active] 401614001888 catalytic site [active] 401614001889 putative substrate binding site [chemical binding]; other site 401614001890 HRDC domain; Region: HRDC; cl02578 401614001891 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 401614001892 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 401614001893 GIY-YIG motif/motif A; other site 401614001894 active site 401614001895 catalytic site [active] 401614001896 putative DNA binding site [nucleotide binding]; other site 401614001897 metal binding site [ion binding]; metal-binding site 401614001898 UvrB/uvrC motif; Region: UVR; pfam02151 401614001899 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 401614001900 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 401614001901 active site 401614001902 Trm112p-like protein; Region: Trm112p; cl01066 401614001903 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 401614001904 Ligand binding site; other site 401614001905 oligomer interface; other site 401614001906 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 401614001907 galactokinase; Provisional; Region: PRK05322 401614001908 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 401614001909 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401614001910 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 401614001911 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 401614001912 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 401614001913 dimer interface [polypeptide binding]; other site 401614001914 active site 401614001915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001916 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614001917 putative substrate translocation pore; other site 401614001918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001919 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614001920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001921 putative substrate translocation pore; other site 401614001922 PPIC-type PPIASE domain; Region: Rotamase; cl08278 401614001923 helicase 45; Provisional; Region: PTZ00424 401614001924 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 401614001925 ATP binding site [chemical binding]; other site 401614001926 Mg++ binding site [ion binding]; other site 401614001927 motif III; other site 401614001928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614001929 nucleotide binding region [chemical binding]; other site 401614001930 ATP-binding site [chemical binding]; other site 401614001931 DbpA RNA binding domain; Region: DbpA; pfam03880 401614001932 Guanylate kinase; Region: Guanylate_kin; pfam00625 401614001933 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 401614001934 catalytic site [active] 401614001935 G-X2-G-X-G-K; other site 401614001936 Quinolinate synthetase A protein; Region: NadA; cl00420 401614001937 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 401614001938 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 401614001939 dimerization interface [polypeptide binding]; other site 401614001940 active site 401614001941 L-aspartate oxidase; Provisional; Region: PRK09077 401614001942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001943 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 401614001944 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 401614001945 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401614001946 active site 401614001947 Chorismate mutase type II; Region: CM_2; cl00693 401614001948 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 401614001949 catalytic residues [active] 401614001950 dimer interface [polypeptide binding]; other site 401614001951 Protein of unknown function (DUF819); Region: DUF819; cl02317 401614001952 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 401614001953 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 401614001954 active site 401614001955 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 401614001956 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 401614001957 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 401614001958 putative substrate binding site [chemical binding]; other site 401614001959 putative ATP binding site [chemical binding]; other site 401614001960 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 401614001961 HsdM N-terminal domain; Region: HsdM_N; pfam12161 401614001962 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 401614001963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614001964 Abi-like protein; Region: Abi_2; cl01988 401614001965 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 401614001966 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614001967 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614001968 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 401614001969 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 401614001970 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 401614001971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614001972 ATP binding site [chemical binding]; other site 401614001973 putative Mg++ binding site [ion binding]; other site 401614001974 Protein of unknown function DUF45; Region: DUF45; cl00636 401614001975 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614001976 RNA binding surface [nucleotide binding]; other site 401614001977 OstA-like protein; Region: OstA; cl00844 401614001978 Organic solvent tolerance protein; Region: OstA_C; pfam04453 401614001979 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 401614001980 Predicted membrane protein [Function unknown]; Region: COG1289 401614001981 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 401614001982 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 401614001983 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614001984 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614001985 Transcriptional regulator [Transcription]; Region: IclR; COG1414 401614001986 Helix-turn-helix domains; Region: HTH; cl00088 401614001987 Bacterial transcriptional regulator; Region: IclR; pfam01614 401614001988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 401614001989 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 401614001990 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 401614001991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614001992 FeS/SAM binding site; other site 401614001993 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 401614001994 DNA-binding site [nucleotide binding]; DNA binding site 401614001995 RNA-binding motif; other site 401614001996 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 401614001997 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 401614001998 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 401614001999 Cation efflux family; Region: Cation_efflux; cl00316 401614002000 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 401614002001 active site 401614002002 tetramer interface; other site 401614002003 acetyl-CoA synthetase; Provisional; Region: PRK00174 401614002004 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 401614002005 AMP-binding enzyme; Region: AMP-binding; cl15778 401614002006 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401614002007 EamA-like transporter family; Region: EamA; cl01037 401614002008 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 401614002009 EamA-like transporter family; Region: EamA; cl01037 401614002010 recombination protein F; Reviewed; Region: recF; PRK00064 401614002011 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002012 Walker A/P-loop; other site 401614002013 ATP binding site [chemical binding]; other site 401614002014 Q-loop/lid; other site 401614002015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002016 ABC transporter signature motif; other site 401614002017 Walker B; other site 401614002018 D-loop; other site 401614002019 H-loop/switch region; other site 401614002020 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 401614002021 active site 401614002022 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 401614002023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614002024 dimer interface [polypeptide binding]; other site 401614002025 conserved gate region; other site 401614002026 putative PBP binding loops; other site 401614002027 ABC-ATPase subunit interface; other site 401614002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614002029 dimer interface [polypeptide binding]; other site 401614002030 conserved gate region; other site 401614002031 putative PBP binding loops; other site 401614002032 ABC-ATPase subunit interface; other site 401614002033 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 401614002034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002035 Walker A/P-loop; other site 401614002036 ATP binding site [chemical binding]; other site 401614002037 Q-loop/lid; other site 401614002038 ABC transporter signature motif; other site 401614002039 Walker B; other site 401614002040 D-loop; other site 401614002041 H-loop/switch region; other site 401614002042 TOBE domain; Region: TOBE_2; cl01440 401614002043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614002044 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 401614002045 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 401614002046 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614002047 Integral membrane protein TerC family; Region: TerC; cl10468 401614002048 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 401614002049 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 401614002050 putative C-terminal domain interface [polypeptide binding]; other site 401614002051 putative GSH binding site [chemical binding]; other site 401614002052 putative dimer interface [polypeptide binding]; other site 401614002053 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 401614002054 dimer interface [polypeptide binding]; other site 401614002055 substrate binding pocket (H-site) [chemical binding]; other site 401614002056 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 401614002057 putative N-terminal domain interface [polypeptide binding]; other site 401614002058 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 401614002059 alanine racemase; Reviewed; Region: alr; PRK00053 401614002060 active site 401614002061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614002062 dimer interface [polypeptide binding]; other site 401614002063 substrate binding site [chemical binding]; other site 401614002064 catalytic residues [active] 401614002065 amino acid transporter; Region: 2A0306; TIGR00909 401614002066 Spore germination protein; Region: Spore_permease; cl15802 401614002067 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 401614002068 Prephenate dehydratase; Region: PDT; pfam00800 401614002069 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 401614002070 putative L-Phe binding site [chemical binding]; other site 401614002071 Protein of unknown function DUF45; Region: DUF45; cl00636 401614002072 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 401614002073 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 401614002074 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 401614002075 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 401614002076 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 401614002077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002078 catalytic residue [active] 401614002079 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 401614002080 Domain of unknown function DUF59; Region: DUF59; cl00941 401614002081 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 401614002082 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 401614002083 active site 401614002084 (T/H)XGH motif; other site 401614002085 ferredoxin; Validated; Region: PRK07118 401614002086 outer membrane protein A; Reviewed; Region: PRK10808 401614002087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 401614002088 ligand binding site [chemical binding]; other site 401614002089 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 401614002090 CRISPR-associated protein Cas9/Csx12, subtype II-B/NMENI; Region: cas_csx12; TIGR03031 401614002091 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 401614002092 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 401614002093 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 401614002094 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 401614002095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002096 FeS/SAM binding site; other site 401614002097 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 401614002098 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614002099 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 401614002100 active site 401614002101 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 401614002102 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 401614002103 active site 401614002104 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 401614002105 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 401614002106 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 401614002107 BCCT family transporter; Region: BCCT; cl00569 401614002108 TspO/MBR family; Region: TspO_MBR; cl01379 401614002109 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 401614002110 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 401614002111 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 401614002112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614002113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002114 putative substrate translocation pore; other site 401614002115 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 401614002116 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 401614002117 catalytic residues [active] 401614002118 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 401614002119 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 401614002120 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 401614002121 Oligomerisation domain; Region: Oligomerisation; cl00519 401614002122 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 401614002123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002124 Family description; Region: UvrD_C_2; cl15862 401614002125 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 401614002126 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 401614002127 motif 1; other site 401614002128 active site 401614002129 motif 2; other site 401614002130 motif 3; other site 401614002131 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 401614002132 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 401614002133 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 401614002134 interface (dimer of trimers) [polypeptide binding]; other site 401614002135 Substrate-binding/catalytic site; other site 401614002136 Zn-binding sites [ion binding]; other site 401614002137 transaldolase-like protein; Provisional; Region: PTZ00411 401614002138 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 401614002139 active site 401614002140 dimer interface [polypeptide binding]; other site 401614002141 catalytic residue [active] 401614002142 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 401614002143 Isochorismatase family; Region: Isochorismatase; pfam00857 401614002144 catalytic triad [active] 401614002145 conserved cis-peptide bond; other site 401614002146 Isochorismatase family; Region: Isochorismatase; pfam00857 401614002147 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 401614002148 catalytic triad [active] 401614002149 conserved cis-peptide bond; other site 401614002150 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 401614002151 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 401614002152 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 401614002153 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002155 Family description; Region: UvrD_C_2; cl15862 401614002156 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 401614002157 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614002158 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614002159 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 401614002160 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 401614002161 active site residue [active] 401614002162 Putative exonuclease, RdgC; Region: RdgC; cl01122 401614002163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401614002164 non-specific DNA binding site [nucleotide binding]; other site 401614002165 salt bridge; other site 401614002166 sequence-specific DNA binding site [nucleotide binding]; other site 401614002167 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 401614002168 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 401614002169 THUMP domain; Region: THUMP; cl12076 401614002170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614002172 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 401614002173 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 401614002174 Membrane transport protein; Region: Mem_trans; cl09117 401614002175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614002176 dimerization interface [polypeptide binding]; other site 401614002177 putative DNA binding site [nucleotide binding]; other site 401614002178 putative Zn2+ binding site [ion binding]; other site 401614002179 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 401614002180 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 401614002181 putative active site [active] 401614002182 substrate binding site [chemical binding]; other site 401614002183 putative cosubstrate binding site; other site 401614002184 catalytic site [active] 401614002185 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 401614002186 substrate binding site [chemical binding]; other site 401614002187 glutathione synthetase; Provisional; Region: PRK05246 401614002188 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 401614002189 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614002190 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 401614002191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401614002192 inhibitor-cofactor binding pocket; inhibition site 401614002193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614002194 catalytic residue [active] 401614002195 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401614002196 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 401614002197 classical (c) SDRs; Region: SDR_c; cd05233 401614002198 NAD(P) binding site [chemical binding]; other site 401614002199 active site 401614002200 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 401614002201 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 401614002202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002203 putative substrate translocation pore; other site 401614002204 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614002205 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 401614002206 Helix-turn-helix domains; Region: HTH; cl00088 401614002207 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 401614002208 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 401614002209 AAA domain; Region: AAA_26; pfam13500 401614002210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002212 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 401614002213 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 401614002214 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401614002215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002216 catalytic residue [active] 401614002217 biotin synthase; Region: bioB; TIGR00433 401614002218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002219 FeS/SAM binding site; other site 401614002220 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 401614002221 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401614002222 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 401614002223 inhibitor-cofactor binding pocket; inhibition site 401614002224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614002225 catalytic residue [active] 401614002226 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 401614002227 CoenzymeA binding site [chemical binding]; other site 401614002228 subunit interaction site [polypeptide binding]; other site 401614002229 PHB binding site; other site 401614002230 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 401614002231 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 401614002232 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 401614002233 catalytic center binding site [active] 401614002234 ATP binding site [chemical binding]; other site 401614002235 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 401614002236 dihydropteroate synthase; Region: DHPS; TIGR01496 401614002237 substrate binding pocket [chemical binding]; other site 401614002238 dimer interface [polypeptide binding]; other site 401614002239 inhibitor binding site; inhibition site 401614002240 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 401614002241 active site 401614002242 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 401614002243 AMP-binding enzyme; Region: AMP-binding; cl15778 401614002244 aminodeoxychorismate synthase; Provisional; Region: PRK07508 401614002245 chorismate binding enzyme; Region: Chorismate_bind; cl10555 401614002246 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 401614002247 substrate-cofactor binding pocket; other site 401614002248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614002249 catalytic residue [active] 401614002250 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 401614002251 Glutamine amidotransferase class-I; Region: GATase; pfam00117 401614002252 glutamine binding [chemical binding]; other site 401614002253 catalytic triad [active] 401614002254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614002255 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 401614002256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401614002257 active site 401614002258 catalytic tetrad [active] 401614002259 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 401614002260 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401614002261 active site 401614002262 catalytic tetrad [active] 401614002263 Predicted amidohydrolase [General function prediction only]; Region: COG0388 401614002264 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 401614002265 active site 401614002266 catalytic triad [active] 401614002267 dimer interface [polypeptide binding]; other site 401614002268 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 401614002269 putative active site [active] 401614002270 GTP cyclohydrolase I; Provisional; Region: PLN03044 401614002271 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 401614002272 active site 401614002273 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 401614002274 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 401614002275 ATP binding site [chemical binding]; other site 401614002276 Mg++ binding site [ion binding]; other site 401614002277 motif III; other site 401614002278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614002279 nucleotide binding region [chemical binding]; other site 401614002280 ATP-binding site [chemical binding]; other site 401614002281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614002282 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 401614002283 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 401614002284 glutathione reductase; Validated; Region: PRK06116 401614002285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614002286 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 401614002287 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 401614002288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002289 Walker A motif; other site 401614002290 ATP binding site [chemical binding]; other site 401614002291 Walker B motif; other site 401614002292 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 401614002293 putative active site [active] 401614002294 putative DNA binding site [nucleotide binding]; other site 401614002295 putative phosphate binding site [ion binding]; other site 401614002296 putative catalytic site [active] 401614002297 metal binding site A [ion binding]; metal-binding site 401614002298 putative AP binding site [nucleotide binding]; other site 401614002299 putative metal binding site B [ion binding]; other site 401614002300 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 401614002301 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 401614002302 active site 401614002303 Zn binding site [ion binding]; other site 401614002304 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 401614002305 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 401614002306 potential catalytic triad [active] 401614002307 conserved cys residue [active] 401614002308 NeuB family; Region: NeuB; cl00496 401614002309 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 401614002310 signal recognition particle protein; Provisional; Region: PRK10867 401614002311 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 401614002312 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 401614002313 P loop; other site 401614002314 GTP binding site [chemical binding]; other site 401614002315 Signal peptide binding domain; Region: SRP_SPB; pfam02978 401614002316 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401614002317 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 401614002318 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 401614002319 rRNA binding site [nucleotide binding]; other site 401614002320 predicted 30S ribosome binding site; other site 401614002321 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 401614002322 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614002323 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 401614002324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002325 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 401614002326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002327 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 401614002328 Helix-turn-helix domains; Region: HTH; cl00088 401614002329 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 401614002330 putative ABC transporter; Region: ycf24; CHL00085 401614002331 FeS assembly ATPase SufC; Region: sufC; TIGR01978 401614002332 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 401614002333 Walker A/P-loop; other site 401614002334 ATP binding site [chemical binding]; other site 401614002335 Q-loop/lid; other site 401614002336 ABC transporter signature motif; other site 401614002337 Walker B; other site 401614002338 D-loop; other site 401614002339 H-loop/switch region; other site 401614002340 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 401614002341 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 401614002342 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 401614002343 Amidinotransferase; Region: Amidinotransf; cl12043 401614002344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 401614002345 catalytic residues [active] 401614002346 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 401614002347 Helix-turn-helix domains; Region: HTH; cl00088 401614002348 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 401614002349 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 401614002350 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401614002351 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002352 catalytic residue [active] 401614002353 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401614002354 PAS fold; Region: PAS_4; pfam08448 401614002355 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 401614002356 active site 401614002357 8-oxo-dGMP binding site [chemical binding]; other site 401614002358 nudix motif; other site 401614002359 metal binding site [ion binding]; metal-binding site 401614002360 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 401614002361 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 401614002362 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 401614002363 Sel1 repeat; Region: Sel1; cl02723 401614002364 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 401614002365 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 401614002366 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 401614002367 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 401614002368 HIGH motif; other site 401614002369 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 401614002370 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 401614002371 active site 401614002372 KMSKS motif; other site 401614002373 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 401614002374 tRNA binding surface [nucleotide binding]; other site 401614002375 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 401614002376 Lipopolysaccharide-assembly; Region: LptE; cl01125 401614002377 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 401614002378 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614002379 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 401614002380 trimer interface [polypeptide binding]; other site 401614002381 active site 401614002382 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 401614002383 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 401614002384 Walker A motif; other site 401614002385 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614002386 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 401614002387 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 401614002388 putative active site [active] 401614002389 catalytic site [active] 401614002390 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 401614002391 putative active site [active] 401614002392 catalytic site [active] 401614002393 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 401614002394 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 401614002395 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 401614002396 putative active site [active] 401614002397 catalytic site [active] 401614002398 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 401614002399 putative active site [active] 401614002400 catalytic site [active] 401614002401 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614002402 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 401614002403 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 401614002404 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002405 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 401614002406 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 401614002407 metal binding site 2 [ion binding]; metal-binding site 401614002408 putative DNA binding helix; other site 401614002409 metal binding site 1 [ion binding]; metal-binding site 401614002410 dimer interface [polypeptide binding]; other site 401614002411 structural Zn2+ binding site [ion binding]; other site 401614002412 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 401614002413 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 401614002414 putative tRNA-binding site [nucleotide binding]; other site 401614002415 B3/4 domain; Region: B3_4; cl11458 401614002416 tRNA synthetase B5 domain; Region: B5; cl08394 401614002417 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 401614002418 dimer interface [polypeptide binding]; other site 401614002419 motif 1; other site 401614002420 motif 3; other site 401614002421 motif 2; other site 401614002422 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 401614002423 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 401614002424 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 401614002425 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 401614002426 dimer interface [polypeptide binding]; other site 401614002427 motif 1; other site 401614002428 active site 401614002429 motif 2; other site 401614002430 motif 3; other site 401614002431 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 401614002432 EamA-like transporter family; Region: EamA; cl01037 401614002433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614002434 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 401614002435 MFS/sugar transport protein; Region: MFS_2; pfam13347 401614002436 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 401614002437 catalytic motif [active] 401614002438 Catalytic residue [active] 401614002439 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 401614002440 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 401614002441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 401614002442 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 401614002443 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 401614002444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002445 Walker A motif; other site 401614002446 ATP binding site [chemical binding]; other site 401614002447 Walker B motif; other site 401614002448 arginine finger; other site 401614002449 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 401614002450 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 401614002451 classical (c) SDRs; Region: SDR_c; cd05233 401614002452 NAD(P) binding site [chemical binding]; other site 401614002453 active site 401614002454 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 401614002455 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 401614002456 active site 401614002457 catalytic triad [active] 401614002458 oxyanion hole [active] 401614002459 switch loop; other site 401614002460 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 401614002461 putative active site pocket [active] 401614002462 dimerization interface [polypeptide binding]; other site 401614002463 putative catalytic residue [active] 401614002464 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 401614002465 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 401614002466 TPP-binding site; other site 401614002467 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 401614002468 PYR/PP interface [polypeptide binding]; other site 401614002469 dimer interface [polypeptide binding]; other site 401614002470 TPP binding site [chemical binding]; other site 401614002471 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 401614002472 GMP synthase; Reviewed; Region: guaA; PRK00074 401614002473 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 401614002474 AMP/PPi binding site [chemical binding]; other site 401614002475 candidate oxyanion hole; other site 401614002476 catalytic triad [active] 401614002477 potential glutamine specificity residues [chemical binding]; other site 401614002478 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 401614002479 ATP Binding subdomain [chemical binding]; other site 401614002480 Ligand Binding sites [chemical binding]; other site 401614002481 Dimerization subdomain; other site 401614002482 Amino acid permease; Region: AA_permease_2; pfam13520 401614002483 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 401614002484 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 401614002485 dimerization interface 3.5A [polypeptide binding]; other site 401614002486 active site 401614002487 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401614002488 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 401614002489 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 401614002490 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 401614002491 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 401614002492 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 401614002493 Walker A/P-loop; other site 401614002494 ATP binding site [chemical binding]; other site 401614002495 Q-loop/lid; other site 401614002496 ABC transporter signature motif; other site 401614002497 Walker B; other site 401614002498 D-loop; other site 401614002499 H-loop/switch region; other site 401614002500 OstA-like protein; Region: OstA; cl00844 401614002501 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 401614002502 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 401614002503 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614002504 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 401614002505 dimer interface [polypeptide binding]; other site 401614002506 substrate binding site [chemical binding]; other site 401614002507 metal binding sites [ion binding]; metal-binding site 401614002508 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 401614002509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 401614002510 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 401614002511 Protein of unknown function (DUF493); Region: DUF493; cl01102 401614002512 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 401614002513 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 401614002514 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 401614002515 alpha-glucosidase; Provisional; Region: PRK10426 401614002516 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 401614002517 putative active site [active] 401614002518 putative catalytic site [active] 401614002519 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 401614002520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614002521 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 401614002522 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 401614002523 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 401614002524 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 401614002525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 401614002526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 401614002527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 401614002528 DNA binding residues [nucleotide binding] 401614002529 CHC2 zinc finger; Region: zf-CHC2; cl15369 401614002530 DNA primase; Validated; Region: dnaG; PRK05667 401614002531 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 401614002532 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 401614002533 active site 401614002534 metal binding site [ion binding]; metal-binding site 401614002535 interdomain interaction site; other site 401614002536 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 401614002537 GatB domain; Region: GatB_Yqey; cl11497 401614002538 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 401614002539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 401614002540 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 401614002541 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 401614002542 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401614002543 catalytic residue [active] 401614002544 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 401614002545 active site 401614002546 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 401614002547 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 401614002548 Ligand Binding Site [chemical binding]; other site 401614002549 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 401614002550 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 401614002551 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 401614002552 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 401614002553 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 401614002554 substrate binding pocket [chemical binding]; other site 401614002555 chain length determination region; other site 401614002556 substrate-Mg2+ binding site; other site 401614002557 catalytic residues [active] 401614002558 aspartate-rich region 1; other site 401614002559 active site lid residues [active] 401614002560 aspartate-rich region 2; other site 401614002561 PQ loop repeat; Region: PQ-loop; cl12056 401614002562 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 401614002563 ligand-binding site [chemical binding]; other site 401614002564 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 401614002565 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 401614002566 CysD dimerization site [polypeptide binding]; other site 401614002567 G1 box; other site 401614002568 putative GEF interaction site [polypeptide binding]; other site 401614002569 GTP/Mg2+ binding site [chemical binding]; other site 401614002570 Switch I region; other site 401614002571 G2 box; other site 401614002572 G3 box; other site 401614002573 Switch II region; other site 401614002574 G4 box; other site 401614002575 G5 box; other site 401614002576 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 401614002577 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 401614002578 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 401614002579 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 401614002580 Active Sites [active] 401614002581 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 401614002582 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 401614002583 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 401614002584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002585 G1 box; other site 401614002586 GTP/Mg2+ binding site [chemical binding]; other site 401614002587 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401614002588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002589 Walker A/P-loop; other site 401614002590 ATP binding site [chemical binding]; other site 401614002591 Q-loop/lid; other site 401614002592 ABC transporter signature motif; other site 401614002593 Walker B; other site 401614002594 D-loop; other site 401614002595 H-loop/switch region; other site 401614002596 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 401614002597 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 401614002598 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 401614002599 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 401614002600 Ligand Binding Site [chemical binding]; other site 401614002601 Molecular Tunnel; other site 401614002602 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 401614002603 active site 401614002604 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 401614002605 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 401614002606 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 401614002607 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 401614002608 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614002609 RNA binding surface [nucleotide binding]; other site 401614002610 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 401614002611 probable active site [active] 401614002612 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 401614002613 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 401614002614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002615 FeS/SAM binding site; other site 401614002616 replicative DNA helicase; Region: DnaB; TIGR00665 401614002617 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 401614002618 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 401614002619 Walker A motif; other site 401614002620 ATP binding site [chemical binding]; other site 401614002621 Walker B motif; other site 401614002622 DNA binding loops [nucleotide binding] 401614002623 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 401614002624 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 401614002625 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 401614002626 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 401614002627 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 401614002628 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 401614002629 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 401614002630 catalytic core [active] 401614002631 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401614002632 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 401614002633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002634 catalytic residue [active] 401614002635 cytidylate kinase; Provisional; Region: cmk; PRK00023 401614002636 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 401614002637 CMP-binding site; other site 401614002638 The sites determining sugar specificity; other site 401614002639 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 401614002640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002641 NAD(P) binding site [chemical binding]; other site 401614002642 active site 401614002643 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 401614002644 catalytic triad [active] 401614002645 dimer interface [polypeptide binding]; other site 401614002646 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 401614002647 Helix-turn-helix domains; Region: HTH; cl00088 401614002648 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 401614002649 dimerization interface [polypeptide binding]; other site 401614002650 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614002651 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 401614002652 putative homotetramer interface [polypeptide binding]; other site 401614002653 putative homodimer interface [polypeptide binding]; other site 401614002654 putative allosteric switch controlling residues; other site 401614002655 putative metal binding site [ion binding]; other site 401614002656 putative homodimer-homodimer interface [polypeptide binding]; other site 401614002657 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 401614002658 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 401614002659 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 401614002660 tetrameric interface [polypeptide binding]; other site 401614002661 NAD binding site [chemical binding]; other site 401614002662 catalytic residues [active] 401614002663 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 401614002664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002665 NAD(P) binding site [chemical binding]; other site 401614002666 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 401614002667 putative metal binding site [ion binding]; other site 401614002668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 401614002669 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 401614002670 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 401614002671 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 401614002672 active site 401614002673 substrate binding site [chemical binding]; other site 401614002674 catalytic site [active] 401614002675 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 401614002676 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 401614002677 PhnA protein; Region: PhnA; pfam03831 401614002678 peroxidase; Provisional; Region: PRK15000 401614002679 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 401614002680 dimer interface [polypeptide binding]; other site 401614002681 decamer (pentamer of dimers) interface [polypeptide binding]; other site 401614002682 catalytic triad [active] 401614002683 peroxidatic and resolving cysteines [active] 401614002684 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614002685 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 401614002686 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 401614002687 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 401614002688 putative ATP binding site [chemical binding]; other site 401614002689 putative substrate interface [chemical binding]; other site 401614002690 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 401614002691 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401614002692 catalytic residue [active] 401614002693 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 401614002694 diiron binding motif [ion binding]; other site 401614002695 malate dehydrogenase; Reviewed; Region: PRK06223 401614002696 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 401614002697 NAD(P) binding site [chemical binding]; other site 401614002698 dimer interface [polypeptide binding]; other site 401614002699 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401614002700 substrate binding site [chemical binding]; other site 401614002701 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 401614002702 Class I ribonucleotide reductase; Region: RNR_I; cd01679 401614002703 active site 401614002704 dimer interface [polypeptide binding]; other site 401614002705 catalytic residues [active] 401614002706 effector binding site; other site 401614002707 R2 peptide binding site; other site 401614002708 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 401614002709 GSH binding site [chemical binding]; other site 401614002710 catalytic residues [active] 401614002711 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 401614002712 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 401614002713 GSH binding site [chemical binding]; other site 401614002714 catalytic residues [active] 401614002715 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 401614002716 dimer interface [polypeptide binding]; other site 401614002717 putative radical transfer pathway; other site 401614002718 diiron center [ion binding]; other site 401614002719 tyrosyl radical; other site 401614002720 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 401614002721 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 401614002722 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 401614002723 ABC transporter; Region: ABC_tran_2; pfam12848 401614002724 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 401614002725 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 401614002726 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 401614002727 conserved cys residue [active] 401614002728 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 401614002729 active site 401614002730 DNA polymerase IV; Validated; Region: PRK02406 401614002731 DNA binding site [nucleotide binding] 401614002732 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 401614002733 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 401614002734 FMN binding site [chemical binding]; other site 401614002735 active site 401614002736 catalytic residues [active] 401614002737 substrate binding site [chemical binding]; other site 401614002738 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 401614002739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614002740 S-adenosylmethionine binding site [chemical binding]; other site 401614002741 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 401614002742 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 401614002743 dimer interface [polypeptide binding]; other site 401614002744 active site 401614002745 metal binding site [ion binding]; metal-binding site 401614002746 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614002747 FAD binding domain; Region: FAD_binding_4; pfam01565 401614002748 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 401614002749 Cysteine-rich domain; Region: CCG; pfam02754 401614002750 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 401614002751 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 401614002752 phosphate binding site [ion binding]; other site 401614002753 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 401614002754 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 401614002755 active site 401614002756 HIGH motif; other site 401614002757 dimer interface [polypeptide binding]; other site 401614002758 KMSKS motif; other site 401614002759 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 401614002760 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 401614002761 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 401614002762 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 401614002763 active site 401614002764 HslU subunit interaction site [polypeptide binding]; other site 401614002765 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 401614002766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002767 Walker A motif; other site 401614002768 ATP binding site [chemical binding]; other site 401614002769 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002770 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 401614002771 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614002772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614002773 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 401614002774 Ion channel; Region: Ion_trans_2; cl11596 401614002775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002776 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 401614002777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614002778 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 401614002779 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 401614002780 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 401614002781 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 401614002782 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 401614002783 dimerization domain [polypeptide binding]; other site 401614002784 dimer interface [polypeptide binding]; other site 401614002785 catalytic residues [active] 401614002786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 401614002787 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 401614002788 putative active site [active] 401614002789 catalytic residue [active] 401614002790 GTP-binding protein YchF; Reviewed; Region: PRK09601 401614002791 YchF GTPase; Region: YchF; cd01900 401614002792 G1 box; other site 401614002793 GTP/Mg2+ binding site [chemical binding]; other site 401614002794 Switch I region; other site 401614002795 G2 box; other site 401614002796 Switch II region; other site 401614002797 G3 box; other site 401614002798 G4 box; other site 401614002799 G5 box; other site 401614002800 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 401614002801 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 401614002802 Domain of unknown function DUF21; Region: DUF21; pfam01595 401614002803 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401614002804 Transporter associated domain; Region: CorC_HlyC; cl08393 401614002805 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 401614002806 5S rRNA interface [nucleotide binding]; other site 401614002807 CTC domain interface [polypeptide binding]; other site 401614002808 L16 interface [polypeptide binding]; other site 401614002809 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 401614002810 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 401614002811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614002812 active site 401614002813 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 401614002814 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 401614002815 putative active site [active] 401614002816 Zn binding site [ion binding]; other site 401614002817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002818 putative substrate translocation pore; other site 401614002819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614002821 putative substrate translocation pore; other site 401614002822 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614002823 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 401614002824 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 401614002825 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 401614002826 Isochorismatase family; Region: Isochorismatase; pfam00857 401614002827 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 401614002828 catalytic triad [active] 401614002829 conserved cis-peptide bond; other site 401614002830 Isochorismatase family; Region: Isochorismatase; pfam00857 401614002831 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 401614002832 catalytic triad [active] 401614002833 conserved cis-peptide bond; other site 401614002834 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 401614002835 intersubunit interface [polypeptide binding]; other site 401614002836 active site 401614002837 Zn2+ binding site [ion binding]; other site 401614002838 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401614002839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002840 catalytic residue [active] 401614002841 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 401614002842 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401614002843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 401614002844 Helix-turn-helix domains; Region: HTH; cl00088 401614002845 RmuC family; Region: RmuC; pfam02646 401614002846 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 401614002847 RuvA N terminal domain; Region: RuvA_N; pfam01330 401614002848 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 401614002849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614002851 putative substrate translocation pore; other site 401614002852 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 401614002853 active site 401614002854 putative DNA-binding cleft [nucleotide binding]; other site 401614002855 dimer interface [polypeptide binding]; other site 401614002856 Transcriptional regulator; Region: Transcrip_reg; cl00361 401614002857 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 401614002858 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 401614002859 conserved cys residue [active] 401614002860 lipoyl synthase; Provisional; Region: PRK05481 401614002861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002862 FeS/SAM binding site; other site 401614002863 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 401614002864 Ferritin-like domain; Region: Ferritin; pfam00210 401614002865 ferroxidase diiron center [ion binding]; other site 401614002866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614002867 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614002868 glutaredoxin 2; Provisional; Region: PRK10387 401614002869 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 401614002870 C-terminal domain interface [polypeptide binding]; other site 401614002871 GSH binding site (G-site) [chemical binding]; other site 401614002872 catalytic residues [active] 401614002873 putative dimer interface [polypeptide binding]; other site 401614002874 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 401614002875 N-terminal domain interface [polypeptide binding]; other site 401614002876 electron transport complex protein RnfB; Provisional; Region: PRK05113 401614002877 Putative Fe-S cluster; Region: FeS; pfam04060 401614002878 4Fe-4S binding domain; Region: Fer4; cl02805 401614002879 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 401614002880 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 401614002881 minor groove reading motif; other site 401614002882 helix-hairpin-helix signature motif; other site 401614002883 substrate binding pocket [chemical binding]; other site 401614002884 active site 401614002885 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 401614002886 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 401614002887 YccA-like proteins; Region: YccA_like; cd10433 401614002888 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 401614002889 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 401614002890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614002891 ATP binding site [chemical binding]; other site 401614002892 putative Mg++ binding site [ion binding]; other site 401614002893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614002894 nucleotide binding region [chemical binding]; other site 401614002895 ATP-binding site [chemical binding]; other site 401614002896 TRCF domain; Region: TRCF; cl04088 401614002897 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 401614002898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002899 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 401614002900 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 401614002901 putative valine binding site [chemical binding]; other site 401614002902 dimer interface [polypeptide binding]; other site 401614002903 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 401614002904 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 401614002905 PYR/PP interface [polypeptide binding]; other site 401614002906 dimer interface [polypeptide binding]; other site 401614002907 TPP binding site [chemical binding]; other site 401614002908 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 401614002909 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 401614002910 TPP-binding site [chemical binding]; other site 401614002911 dimer interface [polypeptide binding]; other site 401614002912 Dehydratase family; Region: ILVD_EDD; cl00340 401614002913 threonine synthase; Reviewed; Region: PRK06721 401614002914 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 401614002915 homodimer interface [polypeptide binding]; other site 401614002916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614002917 catalytic residue [active] 401614002918 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 401614002919 Predicted GTPase [General function prediction only]; Region: COG0218 401614002920 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 401614002921 G1 box; other site 401614002922 GTP/Mg2+ binding site [chemical binding]; other site 401614002923 Switch I region; other site 401614002924 G2 box; other site 401614002925 G3 box; other site 401614002926 Switch II region; other site 401614002927 G4 box; other site 401614002928 G5 box; other site 401614002929 Low molecular weight phosphatase family; Region: LMWPc; cd00115 401614002930 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 401614002931 active site 401614002932 FtsH protease regulator HflC; Provisional; Region: PRK11029 401614002933 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 401614002934 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 401614002935 HflK protein; Region: hflK; TIGR01933 401614002936 hypothetical protein; Provisional; Region: PRK07588 401614002937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002938 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 401614002939 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 401614002940 HflX GTPase family; Region: HflX; cd01878 401614002941 G1 box; other site 401614002942 GTP/Mg2+ binding site [chemical binding]; other site 401614002943 Switch I region; other site 401614002944 G2 box; other site 401614002945 G3 box; other site 401614002946 Switch II region; other site 401614002947 G4 box; other site 401614002948 G5 box; other site 401614002949 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 401614002950 Sm1 motif; other site 401614002951 intra - hexamer interaction site; other site 401614002952 inter - hexamer interaction site [polypeptide binding]; other site 401614002953 nucleotide binding pocket [chemical binding]; other site 401614002954 Sm2 motif; other site 401614002955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002956 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 401614002957 SurA N-terminal domain; Region: SurA_N_3; cl07813 401614002958 PPIC-type PPIASE domain; Region: Rotamase; cl08278 401614002959 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 401614002960 IHF dimer interface [polypeptide binding]; other site 401614002961 IHF - DNA interface [nucleotide binding]; other site 401614002962 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 401614002963 Found in ATP-dependent protease La (LON); Region: LON; smart00464 401614002964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002965 Walker A motif; other site 401614002966 ATP binding site [chemical binding]; other site 401614002967 Walker B motif; other site 401614002968 arginine finger; other site 401614002969 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 401614002970 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 401614002971 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 401614002972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002973 Walker A motif; other site 401614002974 ATP binding site [chemical binding]; other site 401614002975 Walker B motif; other site 401614002976 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 401614002977 Clp protease; Region: CLP_protease; pfam00574 401614002978 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 401614002979 oligomer interface [polypeptide binding]; other site 401614002980 active site residues [active] 401614002981 trigger factor; Provisional; Region: tig; PRK01490 401614002982 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 401614002983 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 401614002984 thymidine kinase; Provisional; Region: PRK04296 401614002985 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614002986 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 401614002987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002988 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 401614002989 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 401614002990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002991 FeS/SAM binding site; other site 401614002992 TRAM domain; Region: TRAM; cl01282 401614002993 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 401614002994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614002995 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 401614002996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401614002997 Transporter associated domain; Region: CorC_HlyC; cl08393 401614002998 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 401614002999 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 401614003000 putative active site [active] 401614003001 catalytic triad [active] 401614003002 putative dimer interface [polypeptide binding]; other site 401614003003 VirK protein; Region: VirK; pfam06903 401614003004 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003005 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614003006 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003007 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614003008 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003009 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003010 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003011 beta-lactamase TEM; Provisional; Region: PRK15442 401614003012 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 401614003013 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 401614003014 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 401614003015 active site 401614003016 substrate binding site [chemical binding]; other site 401614003017 Mg2+ binding site [ion binding]; other site 401614003018 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 401614003019 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 401614003020 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 401614003021 active site 401614003022 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 401614003023 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 401614003024 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 401614003025 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 401614003026 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 401614003027 Uncharacterized conserved protein [Function unknown]; Region: COG0327 401614003028 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 401614003029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003030 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614003031 putative substrate translocation pore; other site 401614003032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003033 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 401614003034 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 401614003035 dimer interface [polypeptide binding]; other site 401614003036 active site 401614003037 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 401614003038 dimer interface [polypeptide binding]; other site 401614003039 active site 401614003040 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 401614003041 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 401614003042 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 401614003043 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 401614003044 Rubredoxin; Region: Rubredoxin; pfam00301 401614003045 iron binding site [ion binding]; other site 401614003046 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 401614003047 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 401614003048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614003049 catalytic residue [active] 401614003050 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 401614003051 active site clefts [active] 401614003052 zinc binding site [ion binding]; other site 401614003053 dimer interface [polypeptide binding]; other site 401614003054 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 401614003055 active site 401614003056 homodimer interface [polypeptide binding]; other site 401614003057 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 401614003058 RNA/DNA hybrid binding site [nucleotide binding]; other site 401614003059 active site 401614003060 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 401614003061 hinge; other site 401614003062 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 401614003063 active site 401614003064 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 401614003065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 401614003066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 401614003067 DNA binding residues [nucleotide binding] 401614003068 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 401614003069 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 401614003070 Protein export membrane protein; Region: SecD_SecF; cl14618 401614003071 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 401614003072 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 401614003073 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 401614003074 Protein export membrane protein; Region: SecD_SecF; cl14618 401614003075 Preprotein translocase subunit; Region: YajC; cl00806 401614003076 Isochorismatase family; Region: Isochorismatase; pfam00857 401614003077 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 401614003078 catalytic triad [active] 401614003079 conserved cis-peptide bond; other site 401614003080 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 401614003081 Helix-turn-helix domains; Region: HTH; cl00088 401614003082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614003083 dimerization interface [polypeptide binding]; other site 401614003084 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 401614003085 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 401614003086 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614003087 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614003088 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614003089 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 401614003090 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 401614003091 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 401614003092 Walker A/P-loop; other site 401614003093 ATP binding site [chemical binding]; other site 401614003094 Q-loop/lid; other site 401614003095 ABC transporter signature motif; other site 401614003096 Walker B; other site 401614003097 D-loop; other site 401614003098 H-loop/switch region; other site 401614003099 NIL domain; Region: NIL; cl09633 401614003100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614003101 dimer interface [polypeptide binding]; other site 401614003102 conserved gate region; other site 401614003103 ABC-ATPase subunit interface; other site 401614003104 NMT1-like family; Region: NMT1_2; cl15260 401614003105 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614003106 aromatic amino acid transport protein; Region: araaP; TIGR00837 401614003107 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 401614003108 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 401614003109 active site residue [active] 401614003110 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 401614003111 active site residue [active] 401614003112 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 401614003113 homotrimer interaction site [polypeptide binding]; other site 401614003114 zinc binding site [ion binding]; other site 401614003115 CDP-binding sites; other site 401614003116 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614003117 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614003118 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401614003119 cyanophycin synthetase; Provisional; Region: PRK14016 401614003120 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614003121 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614003122 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614003123 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 401614003124 putative MPT binding site; other site 401614003125 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 401614003126 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 401614003127 active site 401614003128 catalytic site [active] 401614003129 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 401614003130 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 401614003131 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 401614003132 Walker A motif; other site 401614003133 ATP binding site [chemical binding]; other site 401614003134 Walker B motif; other site 401614003135 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 401614003136 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 401614003137 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 401614003138 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 401614003139 Predicted ATPase [General function prediction only]; Region: COG4637 401614003140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614003141 Walker A/P-loop; other site 401614003142 ATP binding site [chemical binding]; other site 401614003143 Q-loop/lid; other site 401614003144 ferrochelatase; Reviewed; Region: hemH; PRK00035 401614003145 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 401614003146 C-terminal domain interface [polypeptide binding]; other site 401614003147 active site 401614003148 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 401614003149 active site 401614003150 N-terminal domain interface [polypeptide binding]; other site 401614003151 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 401614003152 DNA photolyase; Region: DNA_photolyase; pfam00875 401614003153 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 401614003154 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 401614003155 short chain dehydrogenase; Provisional; Region: PRK06701 401614003156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003157 NAD(P) binding site [chemical binding]; other site 401614003158 active site 401614003159 ChaB; Region: ChaB; cl01887 401614003160 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 401614003161 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 401614003162 active site 401614003163 catalytic residues [active] 401614003164 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 401614003165 Flavoprotein; Region: Flavoprotein; cl08021 401614003166 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 401614003167 benzoate transport; Region: 2A0115; TIGR00895 401614003168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003169 putative substrate translocation pore; other site 401614003170 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614003171 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 401614003172 Proline dehydrogenase; Region: Pro_dh; cl03282 401614003173 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 401614003174 Glutamate binding site [chemical binding]; other site 401614003175 NAD binding site [chemical binding]; other site 401614003176 catalytic residues [active] 401614003177 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 401614003178 NAD(P) binding site [chemical binding]; other site 401614003179 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 401614003180 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 401614003181 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 401614003182 active site 401614003183 dimer interface [polypeptide binding]; other site 401614003184 metal binding site [ion binding]; metal-binding site 401614003185 shikimate kinase; Reviewed; Region: aroK; PRK00131 401614003186 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 401614003187 ADP binding site [chemical binding]; other site 401614003188 magnesium binding site [ion binding]; other site 401614003189 putative shikimate binding site; other site 401614003190 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 401614003191 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 401614003192 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 401614003193 Pilus assembly protein, PilP; Region: PilP; cl01235 401614003194 Pilus assembly protein, PilO; Region: PilO; cl01234 401614003195 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 401614003196 adenylate kinase; Reviewed; Region: adk; PRK00279 401614003197 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 401614003198 AMP-binding site [chemical binding]; other site 401614003199 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 401614003200 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614003201 FAD binding domain; Region: FAD_binding_4; pfam01565 401614003202 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 401614003203 GTPase Era; Reviewed; Region: era; PRK00089 401614003204 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 401614003205 G1 box; other site 401614003206 GTP/Mg2+ binding site [chemical binding]; other site 401614003207 Switch I region; other site 401614003208 G2 box; other site 401614003209 Switch II region; other site 401614003210 G3 box; other site 401614003211 G4 box; other site 401614003212 G5 box; other site 401614003213 aspartate aminotransferase; Provisional; Region: PRK05764 401614003214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614003215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003216 homodimer interface [polypeptide binding]; other site 401614003217 catalytic residue [active] 401614003218 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 401614003219 putative active site [active] 401614003220 putative dimer interface [polypeptide binding]; other site 401614003221 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 401614003222 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 401614003223 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 401614003224 active site 401614003225 dimer interface [polypeptide binding]; other site 401614003226 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 401614003227 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 401614003228 GTP/Mg2+ binding site [chemical binding]; other site 401614003229 G4 box; other site 401614003230 G5 box; other site 401614003231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614003232 G1 box; other site 401614003233 G1 box; other site 401614003234 GTP/Mg2+ binding site [chemical binding]; other site 401614003235 Switch I region; other site 401614003236 G2 box; other site 401614003237 G2 box; other site 401614003238 Switch I region; other site 401614003239 G3 box; other site 401614003240 G3 box; other site 401614003241 Switch II region; other site 401614003242 Switch II region; other site 401614003243 G4 box; other site 401614003244 Sel1 repeat; Region: Sel1; cl02723 401614003245 HsdM N-terminal domain; Region: HsdM_N; pfam12161 401614003246 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 401614003247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003248 Transposase IS200 like; Region: Y1_Tnp; cl00848 401614003249 MarC family integral membrane protein; Region: MarC; cl00919 401614003250 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 401614003251 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614003252 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 401614003253 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 401614003254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614003255 ATP binding site [chemical binding]; other site 401614003256 putative Mg++ binding site [ion binding]; other site 401614003257 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 401614003258 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 401614003259 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 401614003260 G1 box; other site 401614003261 putative GEF interaction site [polypeptide binding]; other site 401614003262 GTP/Mg2+ binding site [chemical binding]; other site 401614003263 Switch I region; other site 401614003264 G2 box; other site 401614003265 G3 box; other site 401614003266 Switch II region; other site 401614003267 G4 box; other site 401614003268 G5 box; other site 401614003269 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 401614003270 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 401614003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614003272 S-adenosylmethionine binding site [chemical binding]; other site 401614003273 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 401614003274 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 401614003275 VacJ like lipoprotein; Region: VacJ; cl01073 401614003276 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 401614003277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003278 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 401614003279 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 401614003280 putative coenzyme Q binding site [chemical binding]; other site 401614003281 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 401614003282 SmpB-tmRNA interface; other site 401614003283 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 401614003284 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 401614003285 Ligand Binding Site [chemical binding]; other site 401614003286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003287 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614003288 putative substrate translocation pore; other site 401614003289 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 401614003290 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 401614003291 generic binding surface II; other site 401614003292 generic binding surface I; other site 401614003293 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 401614003294 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 401614003295 metal binding site [ion binding]; metal-binding site 401614003296 dimer interface [polypeptide binding]; other site 401614003297 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 401614003298 putative dimer interface [polypeptide binding]; other site 401614003299 putative active site [active] 401614003300 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 401614003301 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 401614003302 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 401614003303 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 401614003304 Uncharacterized conserved protein [Function unknown]; Region: COG2308 401614003305 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 401614003306 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614003307 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 401614003308 Restriction endonuclease; Region: Mrr_cat; cl00516 401614003309 excinuclease ABC subunit B; Provisional; Region: PRK05298 401614003310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614003311 ATP binding site [chemical binding]; other site 401614003312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614003313 nucleotide binding region [chemical binding]; other site 401614003314 ATP-binding site [chemical binding]; other site 401614003315 Ultra-violet resistance protein B; Region: UvrB; pfam12344 401614003316 UvrB/uvrC motif; Region: UVR; pfam02151 401614003317 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 401614003318 active site 401614003319 substrate binding site [chemical binding]; other site 401614003320 catalytic site [active] 401614003321 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 401614003322 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 401614003323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003324 NAD(P) binding site [chemical binding]; other site 401614003325 active site 401614003326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614003327 Helix-turn-helix domains; Region: HTH; cl00088 401614003328 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614003329 putative effector binding pocket; other site 401614003330 dimerization interface [polypeptide binding]; other site 401614003331 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 401614003332 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 401614003333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003334 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 401614003335 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 401614003336 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401614003337 active site 401614003338 dimer interface [polypeptide binding]; other site 401614003339 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 401614003340 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 401614003341 active site 401614003342 Zn binding site [ion binding]; other site 401614003343 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401614003344 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 401614003345 23S rRNA binding site [nucleotide binding]; other site 401614003346 L21 binding site [polypeptide binding]; other site 401614003347 L13 binding site [polypeptide binding]; other site 401614003348 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 401614003349 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 401614003350 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 401614003351 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 401614003352 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 401614003353 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 401614003354 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 401614003355 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 401614003356 active site 401614003357 dimer interface [polypeptide binding]; other site 401614003358 motif 1; other site 401614003359 motif 2; other site 401614003360 motif 3; other site 401614003361 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 401614003362 anticodon binding site; other site 401614003363 Chitin binding domain; Region: Chitin_bind_3; cl03871 401614003364 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 401614003365 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 401614003366 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 401614003367 lipoyl attachment site [posttranslational modification]; other site 401614003368 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 401614003369 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 401614003370 homodimer interface [polypeptide binding]; other site 401614003371 active site 401614003372 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 401614003373 recombination protein RecR; Provisional; Region: PRK13844 401614003374 RecR protein; Region: RecR; pfam02132 401614003375 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 401614003376 putative active site [active] 401614003377 putative metal-binding site [ion binding]; other site 401614003378 tetramer interface [polypeptide binding]; other site 401614003379 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 401614003380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 401614003381 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 401614003382 synthetase active site [active] 401614003383 NTP binding site [chemical binding]; other site 401614003384 metal binding site [ion binding]; metal-binding site 401614003385 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 401614003386 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 401614003387 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 401614003388 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 401614003389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614003390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003391 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614003392 putative substrate translocation pore; other site 401614003393 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 401614003394 catalytic nucleophile [active] 401614003395 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 401614003396 proposed catalytic triad [active] 401614003397 active site nucleophile [active] 401614003398 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 401614003399 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 401614003400 substrate binding site [chemical binding]; other site 401614003401 ATP binding site [chemical binding]; other site 401614003402 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 401614003403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614003404 motif II; other site 401614003405 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 401614003406 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 401614003407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401614003408 active site 401614003409 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 401614003410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401614003411 active site 401614003412 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 401614003413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003414 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401614003415 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 401614003416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614003417 Walker A/P-loop; other site 401614003418 ATP binding site [chemical binding]; other site 401614003419 Q-loop/lid; other site 401614003420 ABC transporter signature motif; other site 401614003421 Walker B; other site 401614003422 D-loop; other site 401614003423 H-loop/switch region; other site 401614003424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614003425 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 401614003426 putative ADP-binding pocket [chemical binding]; other site 401614003427 UDP-glucose 4-epimerase; Region: PLN02240 401614003428 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 401614003429 NAD binding site [chemical binding]; other site 401614003430 homodimer interface [polypeptide binding]; other site 401614003431 active site 401614003432 substrate binding site [chemical binding]; other site 401614003433 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 401614003434 Bacterial sugar transferase; Region: Bac_transf; cl00939 401614003435 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 401614003436 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 401614003437 substrate binding site [chemical binding]; other site 401614003438 hexamer interface [polypeptide binding]; other site 401614003439 metal binding site [ion binding]; metal-binding site 401614003440 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 401614003441 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 401614003442 putative active site [active] 401614003443 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 401614003444 DoxX; Region: DoxX; cl00976 401614003445 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 401614003446 Protein of unknown function (DUF692); Region: DUF692; cl01263 401614003447 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 401614003448 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 401614003449 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 401614003450 NAD binding site [chemical binding]; other site 401614003451 homotetramer interface [polypeptide binding]; other site 401614003452 homodimer interface [polypeptide binding]; other site 401614003453 substrate binding site [chemical binding]; other site 401614003454 active site 401614003455 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 401614003456 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 401614003457 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 401614003458 dimer interface [polypeptide binding]; other site 401614003459 active site 401614003460 metal binding site [ion binding]; metal-binding site 401614003461 glutathione binding site [chemical binding]; other site 401614003462 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 401614003463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614003464 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 401614003465 active site 401614003466 motif I; other site 401614003467 motif II; other site 401614003468 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614003469 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 401614003470 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 401614003471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003472 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 401614003473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003474 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 401614003475 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 401614003476 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 401614003477 BolA-like protein; Region: BolA; cl00386 401614003478 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401614003479 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401614003480 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 401614003481 Recombination protein O N terminal; Region: RecO_N; cl15812 401614003482 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401614003483 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 401614003484 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614003485 catalytic residue [active] 401614003486 ribonuclease E; Reviewed; Region: rne; PRK10811 401614003487 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 401614003488 homodimer interface [polypeptide binding]; other site 401614003489 oligonucleotide binding site [chemical binding]; other site 401614003490 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 401614003491 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 401614003492 dimerization interface [polypeptide binding]; other site 401614003493 active site 401614003494 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 401614003495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003496 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 401614003497 L-serine binding site [chemical binding]; other site 401614003498 ACT domain interface; other site 401614003499 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 401614003500 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 401614003501 Ligand Binding Site [chemical binding]; other site 401614003502 B3/4 domain; Region: B3_4; cl11458 401614003503 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614003504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614003505 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 401614003506 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 401614003507 active site 401614003508 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 401614003509 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 401614003510 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 401614003511 Ligand binding site; other site 401614003512 metal-binding site 401614003513 Protein of unknown function (DUF615); Region: DUF615; cl01147 401614003514 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 401614003515 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 401614003516 dimer interface [polypeptide binding]; other site 401614003517 glycine-pyridoxal phosphate binding site [chemical binding]; other site 401614003518 active site 401614003519 folate binding site [chemical binding]; other site 401614003520 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614003521 FAD binding domain; Region: FAD_binding_4; pfam01565 401614003522 Berberine and berberine like; Region: BBE; pfam08031 401614003523 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 401614003524 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 401614003525 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614003526 RNA binding surface [nucleotide binding]; other site 401614003527 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 401614003528 active site 401614003529 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 401614003530 Permease; Region: Permease; cl00510 401614003531 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 401614003532 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 401614003533 Walker A/P-loop; other site 401614003534 ATP binding site [chemical binding]; other site 401614003535 Q-loop/lid; other site 401614003536 ABC transporter signature motif; other site 401614003537 Walker B; other site 401614003538 D-loop; other site 401614003539 H-loop/switch region; other site 401614003540 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 401614003541 mce related protein; Region: MCE; pfam02470 401614003542 Protein of unknown function (DUF445); Region: DUF445; pfam04286 401614003543 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 401614003544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 401614003545 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 401614003546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003547 putative substrate translocation pore; other site 401614003548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 401614003549 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 401614003550 AMP-binding enzyme; Region: AMP-binding; cl15778 401614003551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401614003552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 401614003553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401614003554 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 401614003555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003556 putative substrate translocation pore; other site 401614003557 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 401614003558 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614003559 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614003560 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 401614003561 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 401614003562 NAD synthase; Region: NAD_synthase; pfam02540 401614003563 homodimer interface [polypeptide binding]; other site 401614003564 NAD binding pocket [chemical binding]; other site 401614003565 ATP binding pocket [chemical binding]; other site 401614003566 Mg binding site [ion binding]; other site 401614003567 active-site loop [active] 401614003568 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 401614003569 Pirin-related protein [General function prediction only]; Region: COG1741 401614003570 Cupin domain; Region: Cupin_2; cl09118 401614003571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614003572 Helix-turn-helix domains; Region: HTH; cl00088 401614003573 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614003574 putative effector binding pocket; other site 401614003575 dimerization interface [polypeptide binding]; other site 401614003576 chaperone protein DnaJ; Provisional; Region: PRK10767 401614003577 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 401614003578 HSP70 interaction site [polypeptide binding]; other site 401614003579 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 401614003580 substrate binding site [polypeptide binding]; other site 401614003581 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 401614003582 Zn binding sites [ion binding]; other site 401614003583 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 401614003584 dimer interface [polypeptide binding]; other site 401614003585 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 401614003586 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 401614003587 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 401614003588 dimer interface [polypeptide binding]; other site 401614003589 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 401614003590 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 401614003591 MltA specific insert domain; Region: MltA; cl08398 401614003592 3D domain; Region: 3D; cl01439 401614003593 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 401614003594 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 401614003595 23S rRNA interface [nucleotide binding]; other site 401614003596 L3 interface [polypeptide binding]; other site 401614003597 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 401614003598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614003599 Stringent starvation protein B; Region: SspB; cl01120 401614003600 Sodium:solute symporter family; Region: SSF; cl00456 401614003601 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 401614003602 RNA/DNA hybrid binding site [nucleotide binding]; other site 401614003603 active site 401614003604 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 401614003605 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 401614003606 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 401614003607 active site 401614003608 phosphorylation site [posttranslational modification] 401614003609 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 401614003610 30S subunit binding site; other site 401614003611 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 401614003612 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 401614003613 trmE is a tRNA modification GTPase; Region: trmE; cd04164 401614003614 G1 box; other site 401614003615 GTP/Mg2+ binding site [chemical binding]; other site 401614003616 Switch I region; other site 401614003617 G2 box; other site 401614003618 Switch II region; other site 401614003619 G3 box; other site 401614003620 G4 box; other site 401614003621 G5 box; other site 401614003622 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 401614003623 Helix-turn-helix domains; Region: HTH; cl00088 401614003624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614003625 dimerization interface [polypeptide binding]; other site 401614003626 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 401614003627 active site 401614003628 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 401614003629 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 401614003630 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 401614003631 dimer interface [polypeptide binding]; other site 401614003632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003633 catalytic residue [active] 401614003634 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 401614003635 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 401614003636 DNA polymerase III PolC; Validated; Region: polC; PRK00448 401614003637 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 401614003638 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 401614003639 Intracellular growth locus C protein; Region: IglC; pfam11550 401614003640 Protein of unknown function (DUF877); Region: DUF877; pfam05943 401614003641 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 401614003642 Protein of unknown function (DUF770); Region: DUF770; cl01402 401614003643 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 401614003644 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 401614003645 hypothetical protein; Provisional; Region: PRK08185 401614003646 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 401614003647 intersubunit interface [polypeptide binding]; other site 401614003648 active site 401614003649 zinc binding site [ion binding]; other site 401614003650 Na+ binding site [ion binding]; other site 401614003651 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 401614003652 pyruvate kinase; Provisional; Region: PRK05826 401614003653 domain interfaces; other site 401614003654 active site 401614003655 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 401614003656 Phosphoglycerate kinase; Region: PGK; pfam00162 401614003657 substrate binding site [chemical binding]; other site 401614003658 hinge regions; other site 401614003659 ADP binding site [chemical binding]; other site 401614003660 catalytic site [active] 401614003661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003662 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 401614003663 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 401614003664 transketolase; Reviewed; Region: PRK05899 401614003665 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 401614003666 TPP-binding site [chemical binding]; other site 401614003667 dimer interface [polypeptide binding]; other site 401614003668 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 401614003669 PYR/PP interface [polypeptide binding]; other site 401614003670 dimer interface [polypeptide binding]; other site 401614003671 TPP binding site [chemical binding]; other site 401614003672 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 401614003673 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 401614003674 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 401614003675 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 401614003676 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 401614003677 dimer interface [polypeptide binding]; other site 401614003678 active site 401614003679 CoA binding pocket [chemical binding]; other site 401614003680 Acyl transferase domain; Region: Acyl_transf_1; cl08282 401614003681 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 401614003682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 401614003683 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 401614003684 NAD(P) binding site [chemical binding]; other site 401614003685 homotetramer interface [polypeptide binding]; other site 401614003686 homodimer interface [polypeptide binding]; other site 401614003687 active site 401614003688 Phosphopantetheine attachment site; Region: PP-binding; cl09936 401614003689 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 401614003690 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 401614003691 dimer interface [polypeptide binding]; other site 401614003692 active site 401614003693 YCII-related domain; Region: YCII; cl00999 401614003694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614003695 putative transporter; Provisional; Region: PRK03699 401614003696 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 401614003697 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 401614003698 active site 401614003699 dimerization interface [polypeptide binding]; other site 401614003700 16S rRNA methyltransferase B; Provisional; Region: PRK10901 401614003701 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 401614003702 putative RNA binding site [nucleotide binding]; other site 401614003703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614003704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 401614003705 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 401614003706 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 401614003707 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 401614003708 nucleotide binding pocket [chemical binding]; other site 401614003709 K-X-D-G motif; other site 401614003710 catalytic site [active] 401614003711 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 401614003712 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 401614003713 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 401614003714 Dimer interface [polypeptide binding]; other site 401614003715 BRCT sequence motif; other site 401614003716 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 401614003717 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 401614003718 active site 401614003719 oligomerization interface [polypeptide binding]; other site 401614003720 metal binding site [ion binding]; metal-binding site 401614003721 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401614003722 pantoate--beta-alanine ligase; Region: panC; TIGR00018 401614003723 active site 401614003724 nucleotide binding site [chemical binding]; other site 401614003725 HIGH motif; other site 401614003726 KMSKS motif; other site 401614003727 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 401614003728 tetramerization interface [polypeptide binding]; other site 401614003729 active site 401614003730 Type III pantothenate kinase; Region: Pan_kinase; cl09130 401614003731 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 401614003732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614003733 Family description; Region: UvrD_C_2; cl15862 401614003734 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 401614003735 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 401614003736 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 401614003737 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 401614003738 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 401614003739 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 401614003740 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 401614003741 active site 401614003742 FMN binding site [chemical binding]; other site 401614003743 substrate binding site [chemical binding]; other site 401614003744 3Fe-4S cluster binding site [ion binding]; other site 401614003745 EamA-like transporter family; Region: EamA; cl01037 401614003746 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 401614003747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401614003748 non-specific DNA binding site [nucleotide binding]; other site 401614003749 salt bridge; other site 401614003750 sequence-specific DNA binding site [nucleotide binding]; other site 401614003751 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 401614003752 Catalytic site [active] 401614003753 FeoA domain; Region: FeoA; cl00838 401614003754 Sporulation related domain; Region: SPOR; cl10051 401614003755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 401614003756 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 401614003757 active site 401614003758 Fe-S metabolism associated domain; Region: SufE; cl00951 401614003759 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 401614003760 prolyl-tRNA synthetase; Provisional; Region: PRK09194 401614003761 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 401614003762 dimer interface [polypeptide binding]; other site 401614003763 motif 1; other site 401614003764 active site 401614003765 motif 2; other site 401614003766 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 401614003767 putative deacylase active site [active] 401614003768 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 401614003769 active site 401614003770 motif 3; other site 401614003771 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 401614003772 anticodon binding site; other site 401614003773 Transposase IS200 like; Region: Y1_Tnp; cl00848 401614003774 methionine aminotransferase; Validated; Region: PRK09082 401614003775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614003776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003777 homodimer interface [polypeptide binding]; other site 401614003778 catalytic residue [active] 401614003779 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614003780 Predicted amidohydrolase [General function prediction only]; Region: COG0388 401614003781 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 401614003782 putative active site [active] 401614003783 catalytic triad [active] 401614003784 multimer interface [polypeptide binding]; other site 401614003785 dimer interface [polypeptide binding]; other site 401614003786 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 401614003787 putative RNA binding site [nucleotide binding]; other site 401614003788 Flagellin N-methylase; Region: FliB; cl00497 401614003789 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 401614003790 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 401614003791 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 401614003792 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401614003793 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 401614003794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 401614003795 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 401614003796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614003797 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 401614003798 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 401614003799 active site residue [active] 401614003800 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 401614003801 active site residue [active] 401614003802 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614003803 putative DNA binding site [nucleotide binding]; other site 401614003804 putative Zn2+ binding site [ion binding]; other site 401614003805 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 401614003806 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 401614003807 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 401614003808 Predicted acetyltransferase [General function prediction only]; Region: COG3153 401614003809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401614003810 Coenzyme A binding pocket [chemical binding]; other site 401614003811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 401614003812 LysE type translocator; Region: LysE; cl00565 401614003813 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 401614003814 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 401614003815 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 401614003816 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 401614003817 Ligand binding site; other site 401614003818 Putative Catalytic site; other site 401614003819 DXD motif; other site 401614003820 ABC-2 type transporter; Region: ABC2_membrane; cl11417 401614003821 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 401614003822 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 401614003823 Walker A/P-loop; other site 401614003824 ATP binding site [chemical binding]; other site 401614003825 Q-loop/lid; other site 401614003826 ABC transporter signature motif; other site 401614003827 Walker B; other site 401614003828 D-loop; other site 401614003829 H-loop/switch region; other site 401614003830 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 401614003831 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401614003832 Cupin domain; Region: Cupin_2; cl09118 401614003833 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 401614003834 active site 401614003835 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 401614003836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003837 putative substrate translocation pore; other site 401614003838 Ferritin-like domain; Region: Ferritin; pfam00210 401614003839 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 401614003840 dinuclear metal binding motif [ion binding]; other site 401614003841 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 401614003842 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 401614003843 dimer interface [polypeptide binding]; other site 401614003844 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 401614003845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614003846 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 401614003847 Walker A motif; other site 401614003848 ATP binding site [chemical binding]; other site 401614003849 Walker B motif; other site 401614003850 recombination factor protein RarA; Provisional; Region: PRK14700 401614003851 arginine finger; other site 401614003852 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 401614003853 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 401614003854 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 401614003855 catalytic residues [active] 401614003856 transcription termination factor Rho; Provisional; Region: rho; PRK09376 401614003857 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 401614003858 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 401614003859 RNA binding site [nucleotide binding]; other site 401614003860 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 401614003861 multimer interface [polypeptide binding]; other site 401614003862 Walker A motif; other site 401614003863 ATP binding site [chemical binding]; other site 401614003864 Walker B motif; other site 401614003865 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 401614003866 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 401614003867 active site 401614003868 substrate binding site [chemical binding]; other site 401614003869 metal binding site [ion binding]; metal-binding site 401614003870 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 401614003871 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 401614003872 Substrate binding site; other site 401614003873 Cupin domain; Region: Cupin_2; cl09118 401614003874 MatE; Region: MatE; cl10513 401614003875 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 401614003876 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 401614003877 active site 401614003878 dimer interface [polypeptide binding]; other site 401614003879 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 401614003880 Ligand Binding Site [chemical binding]; other site 401614003881 Molecular Tunnel; other site 401614003882 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 401614003883 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401614003884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614003885 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 401614003886 putative ADP-binding pocket [chemical binding]; other site 401614003887 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 401614003888 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 401614003889 NAD binding site [chemical binding]; other site 401614003890 substrate binding site [chemical binding]; other site 401614003891 homodimer interface [polypeptide binding]; other site 401614003892 active site 401614003893 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 401614003894 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 401614003895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003896 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 401614003897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614003898 putative ADP-binding pocket [chemical binding]; other site 401614003899 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 401614003900 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 401614003901 putative trimer interface [polypeptide binding]; other site 401614003902 putative CoA binding site [chemical binding]; other site 401614003903 Bacterial sugar transferase; Region: Bac_transf; cl00939 401614003904 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 401614003905 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 401614003906 inhibitor-cofactor binding pocket; inhibition site 401614003907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003908 catalytic residue [active] 401614003909 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 401614003910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003911 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 401614003912 NAD(P) binding site [chemical binding]; other site 401614003913 homodimer interface [polypeptide binding]; other site 401614003914 substrate binding site [chemical binding]; other site 401614003915 active site 401614003916 DEAD-like helicases superfamily; Region: DEXDc; smart00487 401614003917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614003918 ATP binding site [chemical binding]; other site 401614003919 putative Mg++ binding site [ion binding]; other site 401614003920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614003921 nucleotide binding region [chemical binding]; other site 401614003922 ATP-binding site [chemical binding]; other site 401614003923 Helicase associated domain (HA2); Region: HA2; cl04503 401614003924 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 401614003925 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 401614003926 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 401614003927 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 401614003928 ArsC family; Region: ArsC; pfam03960 401614003929 catalytic residues [active] 401614003930 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 401614003931 AMP-binding enzyme; Region: AMP-binding; cl15778 401614003932 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401614003933 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 401614003934 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 401614003935 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 401614003936 active site 401614003937 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 401614003938 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 401614003939 acyl-CoA binding pocket [chemical binding]; other site 401614003940 CoA binding site [chemical binding]; other site 401614003941 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 401614003942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003943 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 401614003944 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 401614003945 substrate binding site [chemical binding]; other site 401614003946 oxyanion hole (OAH) forming residues; other site 401614003947 trimer interface [polypeptide binding]; other site 401614003948 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 401614003949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 401614003950 dimer interface [polypeptide binding]; other site 401614003951 active site 401614003952 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 401614003953 CoenzymeA binding site [chemical binding]; other site 401614003954 subunit interaction site [polypeptide binding]; other site 401614003955 PHB binding site; other site 401614003956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003957 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614003958 putative substrate translocation pore; other site 401614003959 Protein of unknown function (DUF465); Region: DUF465; cl01070 401614003960 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 401614003961 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 401614003962 active site 401614003963 ornithine cyclodeaminase; Validated; Region: PRK07589 401614003964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003965 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 401614003966 Amidinotransferase; Region: Amidinotransf; cl12043 401614003967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 401614003968 TolB amino-terminal domain; Region: TolB_N; cl00639 401614003969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401614003970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401614003971 active site 401614003972 phosphorylation site [posttranslational modification] 401614003973 intermolecular recognition site; other site 401614003974 dimerization interface [polypeptide binding]; other site 401614003975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401614003976 DNA binding site [nucleotide binding] 401614003977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 401614003978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614003979 ATP binding site [chemical binding]; other site 401614003980 Mg2+ binding site [ion binding]; other site 401614003981 G-X-G motif; other site 401614003982 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 401614003983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003984 Uncharacterized conserved protein [Function unknown]; Region: COG3496 401614003985 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 401614003986 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 401614003987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614003988 S-adenosylmethionine binding site [chemical binding]; other site 401614003989 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 401614003990 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 401614003991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003992 NAD(P) binding site [chemical binding]; other site 401614003993 active site 401614003994 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 401614003995 Fatty acid desaturase; Region: FA_desaturase; pfam00487 401614003996 Di-iron ligands [ion binding]; other site 401614003997 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 401614003998 ribonuclease R; Region: RNase_R; TIGR02063 401614003999 RNB domain; Region: RNB; pfam00773 401614004000 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 401614004001 RNA binding site [nucleotide binding]; other site 401614004002 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 401614004003 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 401614004004 RNA binding site [nucleotide binding]; other site 401614004005 active site 401614004006 ribonuclease III; Reviewed; Region: rnc; PRK00102 401614004007 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 401614004008 dimerization interface [polypeptide binding]; other site 401614004009 active site 401614004010 metal binding site [ion binding]; metal-binding site 401614004011 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 401614004012 dsRNA binding site [nucleotide binding]; other site 401614004013 signal peptidase I; Provisional; Region: PRK10861 401614004014 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 401614004015 Catalytic site [active] 401614004016 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 401614004017 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 401614004018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401614004019 active site 401614004020 phosphorylation site [posttranslational modification] 401614004021 intermolecular recognition site; other site 401614004022 dimerization interface [polypeptide binding]; other site 401614004023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401614004024 DNA binding site [nucleotide binding] 401614004025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 401614004026 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 401614004027 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 401614004028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004029 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 401614004030 active site 401614004031 dimerization interface [polypeptide binding]; other site 401614004032 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 401614004033 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 401614004034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401614004035 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 401614004036 substrate binding pocket [chemical binding]; other site 401614004037 chain length determination region; other site 401614004038 substrate-Mg2+ binding site; other site 401614004039 catalytic residues [active] 401614004040 aspartate-rich region 1; other site 401614004041 active site lid residues [active] 401614004042 aspartate-rich region 2; other site 401614004043 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401614004044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614004045 active site 401614004046 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401614004047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004048 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 401614004049 active site 401614004050 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 401614004051 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 401614004052 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 401614004053 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 401614004054 active site 401614004055 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 401614004056 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 401614004057 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 401614004058 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 401614004059 trimer interface [polypeptide binding]; other site 401614004060 active site 401614004061 UDP-GlcNAc binding site [chemical binding]; other site 401614004062 lipid binding site [chemical binding]; lipid-binding site 401614004063 periplasmic chaperone; Provisional; Region: PRK10780 401614004064 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 401614004065 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 401614004066 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 401614004067 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 401614004068 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 401614004069 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 401614004070 Surface antigen; Region: Bac_surface_Ag; cl03097 401614004071 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 401614004072 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 401614004073 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 401614004074 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 401614004075 DNA gyrase subunit A; Validated; Region: PRK05560 401614004076 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 401614004077 CAP-like domain; other site 401614004078 active site 401614004079 primary dimer interface [polypeptide binding]; other site 401614004080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004082 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004086 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 401614004087 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 401614004088 ligand binding site [chemical binding]; other site 401614004089 active site 401614004090 UGI interface [polypeptide binding]; other site 401614004091 catalytic site [active] 401614004092 Restriction endonuclease [Defense mechanisms]; Region: COG3587 401614004093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614004094 Virulence protein [General function prediction only]; Region: COG3943 401614004095 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 401614004096 Fic/DOC family; Region: Fic; cl00960 401614004097 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 401614004098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004100 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 401614004101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614004103 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 401614004104 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 401614004105 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004106 E3 interaction surface; other site 401614004107 lipoyl attachment site [posttranslational modification]; other site 401614004108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004109 E3 interaction surface; other site 401614004110 lipoyl attachment site [posttranslational modification]; other site 401614004111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004112 E3 interaction surface; other site 401614004113 lipoyl attachment site [posttranslational modification]; other site 401614004114 e3 binding domain; Region: E3_binding; pfam02817 401614004115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 401614004116 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 401614004117 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 401614004118 dimer interface [polypeptide binding]; other site 401614004119 TPP-binding site [chemical binding]; other site 401614004120 Uncharacterized conserved protein [Function unknown]; Region: COG1565 401614004121 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 401614004122 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 401614004123 dephospho-CoA kinase; Region: TIGR00152 401614004124 CoA-binding site [chemical binding]; other site 401614004125 ATP-binding [chemical binding]; other site 401614004126 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 401614004127 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 401614004128 active site 401614004129 HIGH motif; other site 401614004130 dimer interface [polypeptide binding]; other site 401614004131 KMSKS motif; other site 401614004132 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 401614004133 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 401614004134 Zeta toxin; Region: Zeta_toxin; pfam06414 401614004135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614004136 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 401614004137 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 401614004138 putative active site [active] 401614004139 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 401614004140 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 401614004141 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 401614004142 MutS domain I; Region: MutS_I; pfam01624 401614004143 MutS family domain IV; Region: MutS_IV; pfam05190 401614004144 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614004145 Walker A/P-loop; other site 401614004146 ATP binding site [chemical binding]; other site 401614004147 Q-loop/lid; other site 401614004148 ABC transporter signature motif; other site 401614004149 Walker B; other site 401614004150 D-loop; other site 401614004151 H-loop/switch region; other site 401614004152 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 401614004153 SecA binding site; other site 401614004154 Preprotein binding site; other site 401614004155 hypothetical protein; Provisional; Region: PRK07206 401614004156 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614004157 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614004158 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614004159 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 401614004160 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401614004161 DNA binding site [nucleotide binding] 401614004162 Int/Topo IB signature motif; other site 401614004163 active site 401614004164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614004165 S-adenosylmethionine binding site [chemical binding]; other site 401614004166 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 401614004167 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 401614004168 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 401614004169 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 401614004170 synthetase active site [active] 401614004171 NTP binding site [chemical binding]; other site 401614004172 metal binding site [ion binding]; metal-binding site 401614004173 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 401614004174 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614004175 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401614004176 EamA-like transporter family; Region: EamA; cl01037 401614004177 EamA-like transporter family; Region: EamA; cl01037 401614004178 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 401614004179 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 401614004180 HSP70 interaction site [polypeptide binding]; other site 401614004181 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 401614004182 substrate binding site [polypeptide binding]; other site 401614004183 dimer interface [polypeptide binding]; other site 401614004184 Spore germination protein; Region: Spore_permease; cl15802 401614004185 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 401614004186 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401614004187 mercuric reductase; Validated; Region: PRK06370 401614004188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614004189 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 401614004190 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401614004191 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 401614004192 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 401614004193 DNA binding site [nucleotide binding] 401614004194 active site 401614004195 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614004196 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 401614004197 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 401614004198 active site 401614004199 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614004200 substrate binding site [chemical binding]; other site 401614004201 catalytic residues [active] 401614004202 dimer interface [polypeptide binding]; other site 401614004203 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 401614004204 glutamate dehydrogenase; Provisional; Region: PRK09414 401614004205 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 401614004206 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 401614004207 NAD(P) binding site [chemical binding]; other site 401614004208 HI0933-like protein; Region: HI0933_like; pfam03486 401614004209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004210 Helix-turn-helix domains; Region: HTH; cl00088 401614004211 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 401614004212 short chain dehydrogenase; Validated; Region: PRK06182 401614004213 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 401614004214 NADP binding site [chemical binding]; other site 401614004215 active site 401614004216 steroid binding site; other site 401614004217 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614004218 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 401614004219 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 401614004220 ring oligomerisation interface [polypeptide binding]; other site 401614004221 ATP/Mg binding site [chemical binding]; other site 401614004222 stacking interactions; other site 401614004223 hinge regions; other site 401614004224 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 401614004225 oligomerisation interface [polypeptide binding]; other site 401614004226 mobile loop; other site 401614004227 roof hairpin; other site 401614004228 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 401614004229 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 401614004230 Protein of unknown function (DUF328); Region: DUF328; cl01143 401614004231 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 401614004232 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 401614004233 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 401614004234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614004235 peptide chain release factor 1; Validated; Region: prfA; PRK00591 401614004236 RF-1 domain; Region: RF-1; cl02875 401614004237 RF-1 domain; Region: RF-1; cl02875 401614004238 glutamyl-tRNA reductase; Provisional; Region: PRK13940 401614004239 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 401614004240 tRNA; other site 401614004241 putative tRNA binding site [nucleotide binding]; other site 401614004242 putative NADP binding site [chemical binding]; other site 401614004243 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 401614004244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 401614004245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 401614004246 TPR motif; other site 401614004247 binding surface 401614004248 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 401614004249 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 401614004250 Trp docking motif [polypeptide binding]; other site 401614004251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004252 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614004253 putative substrate translocation pore; other site 401614004254 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 401614004255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 401614004256 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 401614004257 anchoring element; other site 401614004258 dimer interface [polypeptide binding]; other site 401614004259 ATP binding site [chemical binding]; other site 401614004260 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 401614004261 active site 401614004262 metal binding site [ion binding]; metal-binding site 401614004263 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 401614004264 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 401614004265 amidase catalytic site [active] 401614004266 Zn binding residues [ion binding]; other site 401614004267 substrate binding site [chemical binding]; other site 401614004268 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 401614004269 active site 401614004270 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 401614004271 putative active site [active] 401614004272 Ap4A binding site [chemical binding]; other site 401614004273 nudix motif; other site 401614004274 putative metal binding site [ion binding]; other site 401614004275 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 401614004276 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614004277 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 401614004278 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 401614004279 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 401614004280 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401614004281 DNA binding site [nucleotide binding] 401614004282 Int/Topo IB signature motif; other site 401614004283 active site 401614004284 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 401614004285 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 401614004286 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 401614004287 RimM N-terminal domain; Region: RimM; pfam01782 401614004288 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 401614004289 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 401614004290 S-adenosylmethionine synthetase; Validated; Region: PRK05250 401614004291 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 401614004292 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 401614004293 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 401614004294 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 401614004295 Di-iron ligands [ion binding]; other site 401614004296 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 401614004297 UGMP family protein; Validated; Region: PRK09604 401614004298 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 401614004299 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 401614004300 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 401614004301 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 401614004302 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 401614004303 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 401614004304 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 401614004305 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 401614004306 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 401614004307 cleft; other site 401614004308 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 401614004309 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 401614004310 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 401614004311 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 401614004312 DNA binding site [nucleotide binding] 401614004313 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 401614004314 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 401614004315 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 401614004316 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 401614004317 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 401614004318 RPB12 interaction site [polypeptide binding]; other site 401614004319 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 401614004320 RPB11 interaction site [polypeptide binding]; other site 401614004321 RPB12 interaction site [polypeptide binding]; other site 401614004322 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 401614004323 RPB3 interaction site [polypeptide binding]; other site 401614004324 RPB1 interaction site [polypeptide binding]; other site 401614004325 RPB11 interaction site [polypeptide binding]; other site 401614004326 RPB10 interaction site [polypeptide binding]; other site 401614004327 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 401614004328 core dimer interface [polypeptide binding]; other site 401614004329 peripheral dimer interface [polypeptide binding]; other site 401614004330 L10 interface [polypeptide binding]; other site 401614004331 L11 interface [polypeptide binding]; other site 401614004332 putative EF-Tu interaction site [polypeptide binding]; other site 401614004333 putative EF-G interaction site [polypeptide binding]; other site 401614004334 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 401614004335 23S rRNA interface [nucleotide binding]; other site 401614004336 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 401614004337 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 401614004338 mRNA/rRNA interface [nucleotide binding]; other site 401614004339 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 401614004340 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 401614004341 23S rRNA interface [nucleotide binding]; other site 401614004342 L7/L12 interface [polypeptide binding]; other site 401614004343 putative thiostrepton binding site; other site 401614004344 L25 interface [polypeptide binding]; other site 401614004345 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 401614004346 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 401614004347 putative homodimer interface [polypeptide binding]; other site 401614004348 KOW motif; Region: KOW; cl00354 401614004349 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 401614004350 elongation factor Tu; Reviewed; Region: PRK00049 401614004351 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 401614004352 G1 box; other site 401614004353 GEF interaction site [polypeptide binding]; other site 401614004354 GTP/Mg2+ binding site [chemical binding]; other site 401614004355 Switch I region; other site 401614004356 G2 box; other site 401614004357 G3 box; other site 401614004358 Switch II region; other site 401614004359 G4 box; other site 401614004360 G5 box; other site 401614004361 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 401614004362 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 401614004363 Antibiotic Binding Site [chemical binding]; other site 401614004364 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614004365 Family description; Region: UvrD_C_2; cl15862 401614004366 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614004367 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 401614004368 amphipathic channel; other site 401614004369 Asn-Pro-Ala signature motifs; other site 401614004370 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 401614004371 glycerol kinase; Provisional; Region: glpK; PRK00047 401614004372 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 401614004373 N- and C-terminal domain interface [polypeptide binding]; other site 401614004374 active site 401614004375 MgATP binding site [chemical binding]; other site 401614004376 catalytic site [active] 401614004377 metal binding site [ion binding]; metal-binding site 401614004378 glycerol binding site [chemical binding]; other site 401614004379 homotetramer interface [polypeptide binding]; other site 401614004380 homodimer interface [polypeptide binding]; other site 401614004381 FBP binding site [chemical binding]; other site 401614004382 protein IIAGlc interface [polypeptide binding]; other site 401614004383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004384 putative substrate translocation pore; other site 401614004385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004388 putative substrate translocation pore; other site 401614004389 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 401614004390 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 401614004391 Walker A/P-loop; other site 401614004392 ATP binding site [chemical binding]; other site 401614004393 Q-loop/lid; other site 401614004394 ABC transporter signature motif; other site 401614004395 Walker B; other site 401614004396 D-loop; other site 401614004397 H-loop/switch region; other site 401614004398 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 401614004399 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 401614004400 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 401614004401 Walker A/P-loop; other site 401614004402 ATP binding site [chemical binding]; other site 401614004403 Q-loop/lid; other site 401614004404 ABC transporter signature motif; other site 401614004405 Walker B; other site 401614004406 D-loop; other site 401614004407 H-loop/switch region; other site 401614004408 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 401614004409 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 401614004410 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 401614004411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614004412 dimer interface [polypeptide binding]; other site 401614004413 conserved gate region; other site 401614004414 putative PBP binding loops; other site 401614004415 ABC-ATPase subunit interface; other site 401614004416 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 401614004417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614004418 dimer interface [polypeptide binding]; other site 401614004419 conserved gate region; other site 401614004420 putative PBP binding loops; other site 401614004421 ABC-ATPase subunit interface; other site 401614004422 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 401614004423 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 401614004424 peptide binding site [polypeptide binding]; other site 401614004425 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 401614004426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614004427 Family description; Region: UvrD_C_2; cl15862 401614004428 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 401614004429 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 401614004430 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 401614004431 GTP binding site [chemical binding]; other site 401614004432 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 401614004433 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 401614004434 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 401614004435 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 401614004436 G1 box; other site 401614004437 putative GEF interaction site [polypeptide binding]; other site 401614004438 GTP/Mg2+ binding site [chemical binding]; other site 401614004439 Switch I region; other site 401614004440 G2 box; other site 401614004441 G3 box; other site 401614004442 Switch II region; other site 401614004443 G4 box; other site 401614004444 G5 box; other site 401614004445 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 401614004446 thymidylate kinase; Validated; Region: tmk; PRK00698 401614004447 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 401614004448 TMP-binding site; other site 401614004449 ATP-binding site [chemical binding]; other site 401614004450 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 401614004451 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 401614004452 Nucleoside recognition; Region: Gate; cl00486 401614004453 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 401614004454 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 401614004455 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 401614004456 Nucleoside recognition; Region: Gate; cl00486 401614004457 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 401614004458 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 401614004459 intersubunit interface [polypeptide binding]; other site 401614004460 active site 401614004461 catalytic residue [active] 401614004462 Sulfatase; Region: Sulfatase; cl10460 401614004463 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 401614004464 Type III pantothenate kinase; Region: Pan_kinase; cl09130 401614004465 DNA polymerase I; Provisional; Region: PRK05755 401614004466 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 401614004467 active site 401614004468 metal binding site 1 [ion binding]; metal-binding site 401614004469 putative 5' ssDNA interaction site; other site 401614004470 metal binding site 3; metal-binding site 401614004471 metal binding site 2 [ion binding]; metal-binding site 401614004472 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 401614004473 putative DNA binding site [nucleotide binding]; other site 401614004474 putative metal binding site [ion binding]; other site 401614004475 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 401614004476 active site 401614004477 catalytic site [active] 401614004478 substrate binding site [chemical binding]; other site 401614004479 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 401614004480 active site 401614004481 DNA binding site [nucleotide binding] 401614004482 catalytic site [active] 401614004483 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 401614004484 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 401614004485 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 401614004486 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 401614004487 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 401614004488 Walker A/P-loop; other site 401614004489 ATP binding site [chemical binding]; other site 401614004490 Q-loop/lid; other site 401614004491 ABC transporter signature motif; other site 401614004492 Walker B; other site 401614004493 D-loop; other site 401614004494 H-loop/switch region; other site 401614004495 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 401614004496 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 401614004497 active site 401614004498 NTP binding site [chemical binding]; other site 401614004499 metal binding triad [ion binding]; metal-binding site 401614004500 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 401614004501 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 401614004502 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 401614004503 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614004504 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614004505 multidrug efflux protein; Reviewed; Region: PRK09579 401614004506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004507 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 401614004508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004509 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 401614004510 dimer interface [polypeptide binding]; other site 401614004511 catalytic triad [active] 401614004512 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614004513 sensor protein QseC; Provisional; Region: PRK10337 401614004514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401614004515 dimer interface [polypeptide binding]; other site 401614004516 phosphorylation site [posttranslational modification] 401614004517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614004518 ATP binding site [chemical binding]; other site 401614004519 Mg2+ binding site [ion binding]; other site 401614004520 G-X-G motif; other site 401614004521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004522 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 401614004523 NAD(P) binding site [chemical binding]; other site 401614004524 active site 401614004525 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 401614004526 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 401614004527 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 401614004528 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 401614004529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004530 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 401614004531 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 401614004532 Walker A motif; other site 401614004533 ATP binding site [chemical binding]; other site 401614004534 Walker B motif; other site 401614004535 aconitate hydratase; Validated; Region: PRK09277 401614004536 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 401614004537 substrate binding site [chemical binding]; other site 401614004538 ligand binding site [chemical binding]; other site 401614004539 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 401614004540 substrate binding site [chemical binding]; other site 401614004541 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 401614004542 GtrA-like protein; Region: GtrA; cl00971 401614004543 HemN family oxidoreductase; Provisional; Region: PRK05660 401614004544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614004545 FeS/SAM binding site; other site 401614004546 HemN C-terminal domain; Region: HemN_C; pfam06969 401614004547 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 401614004548 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 401614004549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614004550 Preprotein translocase SecG subunit; Region: SecG; cl09123 401614004551 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 401614004552 substrate binding site [chemical binding]; other site 401614004553 dimer interface [polypeptide binding]; other site 401614004554 catalytic triad [active] 401614004555 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 401614004556 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 401614004557 active site 401614004558 substrate binding site [chemical binding]; other site 401614004559 metal binding site [ion binding]; metal-binding site 401614004560 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 401614004561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614004562 active site 401614004563 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004564 E3 interaction surface; other site 401614004565 lipoyl attachment site [posttranslational modification]; other site 401614004566 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 401614004567 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004568 E3 interaction surface; other site 401614004569 lipoyl attachment site [posttranslational modification]; other site 401614004570 e3 binding domain; Region: E3_binding; pfam02817 401614004571 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 401614004572 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 401614004573 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 401614004574 TPP-binding site [chemical binding]; other site 401614004575 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 401614004576 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 401614004577 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 401614004578 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 401614004579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004580 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 401614004581 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 401614004582 SdhC subunit interface [polypeptide binding]; other site 401614004583 proximal heme binding site [chemical binding]; other site 401614004584 cardiolipin binding site; other site 401614004585 Iron-sulfur protein interface; other site 401614004586 proximal quinone binding site [chemical binding]; other site 401614004587 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 401614004588 Iron-sulfur protein interface; other site 401614004589 proximal quinone binding site [chemical binding]; other site 401614004590 SdhD (CybS) interface [polypeptide binding]; other site 401614004591 proximal heme binding site [chemical binding]; other site 401614004592 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 401614004593 dimer interface [polypeptide binding]; other site 401614004594 Citrate synthase; Region: Citrate_synt; pfam00285 401614004595 active site 401614004596 citrylCoA binding site [chemical binding]; other site 401614004597 NADH binding [chemical binding]; other site 401614004598 cationic pore residues; other site 401614004599 oxalacetate/citrate binding site [chemical binding]; other site 401614004600 coenzyme A binding site [chemical binding]; other site 401614004601 catalytic triad [active] 401614004602 muropeptide transporter; Validated; Region: ampG; PRK11010 401614004603 muropeptide transporter; Reviewed; Region: ampG; PRK11902 401614004604 superoxide dismutase; Provisional; Region: PRK10543 401614004605 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 401614004606 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 401614004607 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 401614004608 putative GSH binding site [chemical binding]; other site 401614004609 catalytic residues [active] 401614004610 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 401614004611 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 401614004612 putative active site [active] 401614004613 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 401614004614 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 401614004615 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 401614004616 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 401614004617 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 401614004618 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 401614004619 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 401614004620 alpha subunit interaction interface [polypeptide binding]; other site 401614004621 Walker A motif; other site 401614004622 ATP binding site [chemical binding]; other site 401614004623 Walker B motif; other site 401614004624 inhibitor binding site; inhibition site 401614004625 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 401614004626 ATP synthase; Region: ATP-synt; cl00365 401614004627 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 401614004628 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 401614004629 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 401614004630 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 401614004631 beta subunit interaction interface [polypeptide binding]; other site 401614004632 Walker A motif; other site 401614004633 ATP binding site [chemical binding]; other site 401614004634 Walker B motif; other site 401614004635 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 401614004636 Plant ATP synthase F0; Region: YMF19; cl07975 401614004637 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 401614004638 Plant ATP synthase F0; Region: YMF19; cl07975 401614004639 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 401614004640 ATP synthase subunit C; Region: ATP-synt_C; cl00466 401614004641 ATP synthase A chain; Region: ATP-synt_A; cl00413 401614004642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004644 putative substrate translocation pore; other site 401614004645 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 401614004646 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614004647 RNA binding surface [nucleotide binding]; other site 401614004648 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 401614004649 active site 401614004650 Predicted ATPase [General function prediction only]; Region: COG1485 401614004651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004652 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 401614004653 putative substrate translocation pore; other site 401614004654 histidyl-tRNA synthetase; Region: hisS; TIGR00442 401614004655 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 401614004656 dimer interface [polypeptide binding]; other site 401614004657 motif 1; other site 401614004658 active site 401614004659 motif 2; other site 401614004660 motif 3; other site 401614004661 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 401614004662 anticodon binding site; other site 401614004663 Ribosome-binding factor A; Region: RBFA; cl00542 401614004664 translation initiation factor IF-2; Validated; Region: infB; PRK05306 401614004665 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 401614004666 translation initiation factor IF-2; Region: IF-2; TIGR00487 401614004667 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 401614004668 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 401614004669 G1 box; other site 401614004670 putative GEF interaction site [polypeptide binding]; other site 401614004671 GTP/Mg2+ binding site [chemical binding]; other site 401614004672 Switch I region; other site 401614004673 G2 box; other site 401614004674 G3 box; other site 401614004675 Switch II region; other site 401614004676 G4 box; other site 401614004677 G5 box; other site 401614004678 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 401614004679 Translation-initiation factor 2; Region: IF-2; pfam11987 401614004680 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 401614004681 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 401614004682 NusA N-terminal domain; Region: NusA_N; pfam08529 401614004683 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 401614004684 RNA binding site [nucleotide binding]; other site 401614004685 homodimer interface [polypeptide binding]; other site 401614004686 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 401614004687 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 401614004688 G-X-X-G motif; other site 401614004689 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 401614004690 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 401614004691 ribosome maturation protein RimP; Reviewed; Region: PRK00092 401614004692 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 401614004693 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 401614004694 Sm1 motif; other site 401614004695 D3 - B interaction site; other site 401614004696 D1 - D2 interaction site; other site 401614004697 Hfq - Hfq interaction site; other site 401614004698 RNA binding pocket [nucleotide binding]; other site 401614004699 Sm2 motif; other site 401614004700 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 401614004701 substrate binding site [chemical binding]; other site 401614004702 active site 401614004703 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 401614004704 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 401614004705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614004706 Walker A motif; other site 401614004707 ATP binding site [chemical binding]; other site 401614004708 Walker B motif; other site 401614004709 arginine finger; other site 401614004710 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 401614004711 Membrane fusogenic activity; Region: BMFP; cl01115 401614004712 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 401614004713 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 401614004714 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 401614004715 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 401614004716 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 401614004717 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 401614004718 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 401614004719 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 401614004720 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 401614004721 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 401614004722 4Fe-4S binding domain; Region: Fer4; cl02805 401614004723 4Fe-4S binding domain; Region: Fer4; cl02805 401614004724 NADH dehydrogenase; Region: NADHdh; cl00469 401614004725 NADH dehydrogenase subunit G; Validated; Region: PRK09129 401614004726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 401614004727 catalytic loop [active] 401614004728 iron binding site [ion binding]; other site 401614004729 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 401614004730 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 401614004731 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 401614004732 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 401614004733 SLBB domain; Region: SLBB; pfam10531 401614004734 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 401614004735 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 401614004736 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 401614004737 putative dimer interface [polypeptide binding]; other site 401614004738 [2Fe-2S] cluster binding site [ion binding]; other site 401614004739 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 401614004740 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 401614004741 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 401614004742 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 401614004743 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 401614004744 ferric uptake regulator; Provisional; Region: fur; PRK09462 401614004745 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 401614004746 metal binding site 2 [ion binding]; metal-binding site 401614004747 putative DNA binding helix; other site 401614004748 metal binding site 1 [ion binding]; metal-binding site 401614004749 dimer interface [polypeptide binding]; other site 401614004750 structural Zn2+ binding site [ion binding]; other site 401614004751 IucA / IucC family; Region: IucA_IucC; pfam04183 401614004752 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 401614004753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004754 putative substrate translocation pore; other site 401614004755 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 401614004756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 401614004757 dimer interface [polypeptide binding]; other site 401614004758 active site 401614004759 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614004760 catalytic residues [active] 401614004761 substrate binding site [chemical binding]; other site 401614004762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004763 putative substrate translocation pore; other site 401614004764 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614004765 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 401614004766 active site 401614004767 oxyanion hole [active] 401614004768 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 401614004769 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 401614004770 GatB domain; Region: GatB_Yqey; cl11497 401614004771 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 401614004772 Amidase; Region: Amidase; cl11426 401614004773 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 401614004774 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 401614004775 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614004776 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 401614004777 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 401614004778 adenylosuccinate lyase; Provisional; Region: PRK07492 401614004779 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 401614004780 tetramer interface [polypeptide binding]; other site 401614004781 active site 401614004782 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 401614004783 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 401614004784 active site 401614004785 catalytic residues [active] 401614004786 Dam-replacing family; Region: DRP; pfam06044 401614004787 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 401614004788 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 401614004789 dimerization interface [polypeptide binding]; other site 401614004790 ATP binding site [chemical binding]; other site 401614004791 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 401614004792 dimerization interface [polypeptide binding]; other site 401614004793 ATP binding site [chemical binding]; other site 401614004794 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 401614004795 putative active site [active] 401614004796 catalytic triad [active] 401614004797 amidophosphoribosyltransferase; Provisional; Region: PRK09246 401614004798 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 401614004799 active site 401614004800 tetramer interface [polypeptide binding]; other site 401614004801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614004802 active site 401614004803 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 401614004804 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 401614004805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614004806 catalytic residue [active] 401614004807 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 401614004808 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 401614004809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004810 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 401614004811 putative protease; Provisional; Region: PRK15452 401614004812 Peptidase family U32; Region: Peptidase_U32; cl03113 401614004813 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614004814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004815 putative substrate translocation pore; other site 401614004816 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 401614004817 transmembrane helices; other site 401614004818 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 401614004819 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 401614004820 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 401614004821 Amino acid permease; Region: AA_permease_2; pfam13520 401614004822 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 401614004823 GTP1/OBG; Region: GTP1_OBG; pfam01018 401614004824 Obg GTPase; Region: Obg; cd01898 401614004825 G1 box; other site 401614004826 GTP/Mg2+ binding site [chemical binding]; other site 401614004827 Switch I region; other site 401614004828 G2 box; other site 401614004829 G3 box; other site 401614004830 Switch II region; other site 401614004831 G4 box; other site 401614004832 G5 box; other site 401614004833 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 401614004834 aromatic amino acid transport protein; Region: araaP; TIGR00837 401614004835 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 401614004836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401614004837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401614004838 active site 401614004839 phosphorylation site [posttranslational modification] 401614004840 intermolecular recognition site; other site 401614004841 dimerization interface [polypeptide binding]; other site 401614004842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401614004843 DNA binding site [nucleotide binding] 401614004844 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 401614004845 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 401614004846 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 401614004847 Ligand Binding Site [chemical binding]; other site 401614004848 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 401614004849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401614004850 dimer interface [polypeptide binding]; other site 401614004851 phosphorylation site [posttranslational modification] 401614004852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614004853 ATP binding site [chemical binding]; other site 401614004854 Mg2+ binding site [ion binding]; other site 401614004855 G-X-G motif; other site 401614004856 K+-transporting ATPase, c chain; Region: KdpC; cl00944 401614004857 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 401614004858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401614004859 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 401614004860 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 401614004861 formate dehydrogenase; Provisional; Region: PRK07574 401614004862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004863 aspartate aminotransferase; Provisional; Region: PRK05764 401614004864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614004865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614004866 homodimer interface [polypeptide binding]; other site 401614004867 catalytic residue [active] 401614004868 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 401614004869 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 401614004870 active site 401614004871 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614004872 dimer interface [polypeptide binding]; other site 401614004873 catalytic residues [active] 401614004874 substrate binding site [chemical binding]; other site 401614004875 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 401614004876 trimer interface [polypeptide binding]; other site 401614004877 active site 401614004878 substrate binding site [chemical binding]; other site 401614004879 CoA binding site [chemical binding]; other site 401614004880 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 401614004881 dihydrodipicolinate synthase; Region: dapA; TIGR00674 401614004882 dimer interface [polypeptide binding]; other site 401614004883 active site 401614004884 catalytic residue [active] 401614004885 dihydrodipicolinate reductase; Provisional; Region: PRK00048 401614004886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004887 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 401614004888 aspartate kinase III; Validated; Region: PRK09084 401614004889 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 401614004890 nucleotide binding site [chemical binding]; other site 401614004891 substrate binding site [chemical binding]; other site 401614004892 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 401614004893 lysine allosteric regulatory site; other site 401614004894 dimer interface [polypeptide binding]; other site 401614004895 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 401614004896 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 401614004897 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 401614004898 active site 401614004899 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 401614004900 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614004901 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614004902 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614004903 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 401614004904 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 401614004905 Cl- selectivity filter; other site 401614004906 Cl- binding residues [ion binding]; other site 401614004907 pore gating glutamate residue; other site 401614004908 dimer interface [polypeptide binding]; other site 401614004909 H+/Cl- coupling transport residue; other site 401614004910 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 401614004911 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 401614004912 active site 401614004913 Zn binding site [ion binding]; other site 401614004914 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 401614004915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614004916 catalytic residue [active] 401614004917 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 401614004918 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 401614004919 substrate binding site [chemical binding]; other site 401614004920 active site 401614004921 catalytic residues [active] 401614004922 heterodimer interface [polypeptide binding]; other site 401614004923 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 401614004924 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 401614004925 Clp amino terminal domain; Region: Clp_N; pfam02861 401614004926 Clp amino terminal domain; Region: Clp_N; pfam02861 401614004927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614004928 Walker A motif; other site 401614004929 ATP binding site [chemical binding]; other site 401614004930 Walker B motif; other site 401614004931 arginine finger; other site 401614004932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614004933 Walker A motif; other site 401614004934 ATP binding site [chemical binding]; other site 401614004935 Walker B motif; other site 401614004936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 401614004937 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 401614004938 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 401614004939 active site 401614004940 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 401614004941 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614004942 ATP-grasp domain; Region: ATP-grasp_4; cl03087 401614004943 Ferredoxin [Energy production and conversion]; Region: COG1146 401614004944 4Fe-4S binding domain; Region: Fer4; cl02805 401614004945 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 401614004946 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 401614004947 putative acyl-acceptor binding pocket; other site 401614004948 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 401614004949 putative acyl-acceptor binding pocket; other site 401614004950 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 401614004951 putative catalytic site [active] 401614004952 putative metal binding site [ion binding]; other site 401614004953 putative phosphate binding site [ion binding]; other site 401614004954 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 401614004955 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 401614004956 iron-sulfur cluster [ion binding]; other site 401614004957 [2Fe-2S] cluster binding site [ion binding]; other site 401614004958 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 401614004959 hydrophobic ligand binding site; other site 401614004960 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 401614004961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004962 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614004963 putative substrate translocation pore; other site 401614004964 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 401614004965 catalytic triad [active] 401614004966 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 401614004967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004968 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 401614004969 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 401614004970 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 401614004971 putative NAD(P) binding site [chemical binding]; other site 401614004972 substrate binding site [chemical binding]; other site 401614004973 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 401614004974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 401614004975 Walker A/P-loop; other site 401614004976 ATP binding site [chemical binding]; other site 401614004977 Q-loop/lid; other site 401614004978 ABC transporter signature motif; other site 401614004979 Walker B; other site 401614004980 D-loop; other site 401614004981 H-loop/switch region; other site 401614004982 ABC transporter; Region: ABC_tran_2; pfam12848 401614004983 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 401614004984 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614004985 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 401614004986 Ureide permease; Region: Ureide_permease; pfam07168 401614004987 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 401614004988 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 401614004989 substrate binding site [chemical binding]; other site 401614004990 dimer interface [polypeptide binding]; other site 401614004991 ATP binding site [chemical binding]; other site 401614004992 aminopeptidase N; Provisional; Region: pepN; PRK14015 401614004993 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 401614004994 active site 401614004995 Zn binding site [ion binding]; other site 401614004996 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 401614004997 putative dimer interface [polypeptide binding]; other site 401614004998 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 401614004999 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 401614005000 active site 401614005001 ribulose/triose binding site [chemical binding]; other site 401614005002 phosphate binding site [ion binding]; other site 401614005003 substrate (anthranilate) binding pocket [chemical binding]; other site 401614005004 product (indole) binding pocket [chemical binding]; other site 401614005005 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 401614005006 active site 401614005007 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 401614005008 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 401614005009 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 401614005010 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 401614005011 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 401614005012 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 401614005013 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 401614005014 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 401614005015 Glutamine amidotransferase class-I; Region: GATase; pfam00117 401614005016 glutamine binding [chemical binding]; other site 401614005017 catalytic triad [active] 401614005018 anthranilate synthase component I; Provisional; Region: PRK13564 401614005019 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 401614005020 chorismate binding enzyme; Region: Chorismate_bind; cl10555 401614005021 Helix-turn-helix domains; Region: HTH; cl00088 401614005022 ribonuclease G; Provisional; Region: PRK11712 401614005023 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 401614005024 homodimer interface [polypeptide binding]; other site 401614005025 oligonucleotide binding site [chemical binding]; other site