-- dump date 20111121_012226 -- class Genbank::misc_feature -- table misc_feature_note -- id note 484022000001 Replication protein; Region: Rep_1; cl02412 484022000002 shikimate kinase; Reviewed; Region: aroK; PRK00131 484022000003 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 484022000004 ADP binding site [chemical binding]; other site 484022000005 magnesium binding site [ion binding]; other site 484022000006 putative shikimate binding site; other site 484022000007 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 484022000008 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 484022000009 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 484022000010 Pilus assembly protein, PilP; Region: PilP; cl01235 484022000011 Pilus assembly protein, PilO; Region: PilO; cl01234 484022000012 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 484022000013 adenylate kinase; Reviewed; Region: adk; PRK00279 484022000014 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 484022000015 AMP-binding site [chemical binding]; other site 484022000016 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 484022000017 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022000018 FAD binding domain; Region: FAD_binding_4; pfam01565 484022000019 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 484022000020 GTPase Era; Reviewed; Region: era; PRK00089 484022000021 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 484022000022 G1 box; other site 484022000023 GTP/Mg2+ binding site [chemical binding]; other site 484022000024 Switch I region; other site 484022000025 G2 box; other site 484022000026 Switch II region; other site 484022000027 G3 box; other site 484022000028 G4 box; other site 484022000029 G5 box; other site 484022000030 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 484022000031 aspartate aminotransferase; Provisional; Region: PRK08361 484022000032 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022000033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000034 homodimer interface [polypeptide binding]; other site 484022000035 catalytic residue [active] 484022000036 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 484022000037 TIGR03442 family protein; Region: TIGR03442 484022000038 putative active site [active] 484022000039 putative dimer interface [polypeptide binding]; other site 484022000040 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 484022000041 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 484022000042 active site 484022000043 dimer interface [polypeptide binding]; other site 484022000044 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 484022000045 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 484022000046 GTP/Mg2+ binding site [chemical binding]; other site 484022000047 G4 box; other site 484022000048 G5 box; other site 484022000049 G1 box; other site 484022000050 Switch I region; other site 484022000051 G2 box; other site 484022000052 G3 box; other site 484022000053 Switch II region; other site 484022000054 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 484022000055 Sel1 repeat; Region: Sel1; cl02723 484022000056 Sel1 repeat; Region: Sel1; cl02723 484022000057 Thymidine kinase; Region: TK; cl00631 484022000058 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 484022000059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022000060 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 484022000061 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 484022000062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 484022000063 FeS/SAM binding site; other site 484022000064 TRAM domain; Region: TRAM; cl01282 484022000065 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 484022000066 PhoH-like protein; Region: PhoH; cl12134 484022000067 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 484022000068 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484022000069 Transporter associated domain; Region: CorC_HlyC; pfam03471 484022000070 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 484022000071 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 484022000072 putative active site [active] 484022000073 catalytic triad [active] 484022000074 putative dimer interface [polypeptide binding]; other site 484022000075 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 484022000076 Beta-lactamase; Region: Beta-lactamase; cl01009 484022000077 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 484022000078 active site 484022000079 substrate binding site [chemical binding]; other site 484022000080 Mg2+ binding site [ion binding]; other site 484022000081 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 484022000082 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 484022000083 active site 484022000084 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 484022000085 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 484022000086 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 484022000087 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 484022000088 Uncharacterized conserved protein [Function unknown]; Region: COG0327 484022000089 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 484022000090 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 484022000091 active site 484022000092 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 484022000093 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 484022000094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000095 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484022000096 putative substrate translocation pore; other site 484022000097 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 484022000098 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 484022000099 dimer interface [polypeptide binding]; other site 484022000100 active site 484022000101 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484022000102 dimer interface [polypeptide binding]; other site 484022000103 active site 484022000104 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 484022000105 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 484022000106 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 484022000107 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 484022000108 Rubredoxin; Region: Rubredoxin; pfam00301 484022000109 iron binding site [ion binding]; other site 484022000110 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 484022000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000112 catalytic residue [active] 484022000113 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000114 Integrase core domain; Region: rve; cl01316 484022000115 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 484022000116 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 484022000117 G1 box; other site 484022000118 putative GEF interaction site [polypeptide binding]; other site 484022000119 GTP/Mg2+ binding site [chemical binding]; other site 484022000120 Switch I region; other site 484022000121 G2 box; other site 484022000122 G3 box; other site 484022000123 Switch II region; other site 484022000124 G4 box; other site 484022000125 G5 box; other site 484022000126 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 484022000127 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 484022000128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022000129 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 484022000130 NAD(P) binding site [chemical binding]; other site 484022000131 active site 484022000132 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 484022000133 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 484022000134 VacJ like lipoprotein; Region: VacJ; cl01073 484022000135 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 484022000136 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 484022000137 Transposase IS200 like; Region: Y1_Tnp; cl00848 484022000138 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 484022000139 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 484022000140 putative coenzyme Q binding site [chemical binding]; other site 484022000141 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 484022000142 SmpB-tmRNA interface; other site 484022000143 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 484022000144 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 484022000145 Ligand Binding Site [chemical binding]; other site 484022000146 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000147 Integrase core domain; Region: rve; cl01316 484022000148 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 484022000149 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000150 Integrase core domain; Region: rve; cl01316 484022000151 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 484022000152 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 484022000153 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 484022000154 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 484022000155 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 484022000156 substrate binding site [chemical binding]; other site 484022000157 glutamase interaction surface [polypeptide binding]; other site 484022000158 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 484022000159 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 484022000160 catalytic residues [active] 484022000161 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 484022000162 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 484022000163 putative active site [active] 484022000164 oxyanion strand; other site 484022000165 catalytic triad [active] 484022000166 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 484022000167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 484022000168 active site 484022000169 motif I; other site 484022000170 motif II; other site 484022000171 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 484022000172 putative active site pocket [active] 484022000173 4-fold oligomerization interface [polypeptide binding]; other site 484022000174 metal binding residues [ion binding]; metal-binding site 484022000175 3-fold/trimer interface [polypeptide binding]; other site 484022000176 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 484022000177 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022000178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000179 homodimer interface [polypeptide binding]; other site 484022000180 catalytic residue [active] 484022000181 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 484022000182 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 484022000183 NAD binding site [chemical binding]; other site 484022000184 dimerization interface [polypeptide binding]; other site 484022000185 product binding site; other site 484022000186 substrate binding site [chemical binding]; other site 484022000187 zinc binding site [ion binding]; other site 484022000188 catalytic residues [active] 484022000189 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 484022000190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022000191 HisG, C-terminal domain; Region: HisG_C; cl06867 484022000192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000193 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000194 putative substrate translocation pore; other site 484022000195 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484022000196 putative active site [active] 484022000197 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484022000198 putative active site [active] 484022000199 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 484022000200 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 484022000201 generic binding surface II; other site 484022000202 generic binding surface I; other site 484022000203 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484022000204 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 484022000205 metal binding site [ion binding]; metal-binding site 484022000206 dimer interface [polypeptide binding]; other site 484022000207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022000208 Coenzyme A binding pocket [chemical binding]; other site 484022000209 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 484022000210 putative dimer interface [polypeptide binding]; other site 484022000211 putative active site [active] 484022000212 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 484022000213 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 484022000214 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 484022000215 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 484022000216 Uncharacterized conserved protein [Function unknown]; Region: COG2308 484022000217 Domain of unknown function (DUF404); Region: DUF404; pfam04169 484022000218 Domain of unknown function (DUF407); Region: DUF407; pfam04174 484022000219 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000221 putative substrate translocation pore; other site 484022000222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000223 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000224 putative substrate translocation pore; other site 484022000225 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000226 Integrase core domain; Region: rve; cl01316 484022000227 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 484022000228 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 484022000229 ATP binding site [chemical binding]; other site 484022000230 substrate interface [chemical binding]; other site 484022000231 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 484022000232 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 484022000233 substrate binding site [chemical binding]; other site 484022000234 dimer interface [polypeptide binding]; other site 484022000235 ATP binding site [chemical binding]; other site 484022000236 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 484022000237 thiamine phosphate binding site [chemical binding]; other site 484022000238 active site 484022000239 pyrophosphate binding site [ion binding]; other site 484022000240 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 484022000241 ThiS interaction site; other site 484022000242 putative active site [active] 484022000243 tetramer interface [polypeptide binding]; other site 484022000244 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 484022000245 thiS-thiF/thiG interaction site; other site 484022000246 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 484022000247 ThiC family; Region: ThiC; cl08031 484022000248 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 484022000249 Nuclease-related domain; Region: NERD; pfam08378 484022000250 excinuclease ABC subunit B; Provisional; Region: PRK05298 484022000251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022000252 ATP binding site [chemical binding]; other site 484022000253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022000254 nucleotide binding region [chemical binding]; other site 484022000255 ATP-binding site [chemical binding]; other site 484022000256 Ultra-violet resistance protein B; Region: UvrB; pfam12344 484022000257 UvrB/uvrC motif; Region: UVR; pfam02151 484022000258 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 484022000259 active site 484022000260 substrate binding site [chemical binding]; other site 484022000261 catalytic site [active] 484022000262 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 484022000263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022000264 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 484022000265 NAD(P) binding site [chemical binding]; other site 484022000266 active site 484022000267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022000268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022000269 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484022000270 putative effector binding pocket; other site 484022000271 dimerization interface [polypeptide binding]; other site 484022000272 Predicted membrane protein [Function unknown]; Region: COG1289 484022000273 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 484022000274 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 484022000275 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 484022000276 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484022000277 active site 484022000278 dimer interface [polypeptide binding]; other site 484022000279 Pirin-related protein [General function prediction only]; Region: COG1741 484022000280 Cupin domain; Region: Cupin_2; cl09118 484022000281 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 484022000282 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484022000283 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 484022000284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000285 catalytic residue [active] 484022000286 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 484022000287 23S rRNA binding site [nucleotide binding]; other site 484022000288 L21 binding site [polypeptide binding]; other site 484022000289 L13 binding site [polypeptide binding]; other site 484022000290 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 484022000291 translation initiation factor IF-3; Region: infC; TIGR00168 484022000292 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 484022000293 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 484022000294 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 484022000295 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 484022000296 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 484022000297 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 484022000298 active site 484022000299 dimer interface [polypeptide binding]; other site 484022000300 motif 1; other site 484022000301 motif 2; other site 484022000302 motif 3; other site 484022000303 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 484022000304 anticodon binding site; other site 484022000305 Chitin binding domain; Region: Chitin_bind_3; cl03871 484022000306 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 484022000307 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 484022000308 lipoyl attachment site [posttranslational modification]; other site 484022000309 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 484022000310 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 484022000311 homodimer interface [polypeptide binding]; other site 484022000312 active site 484022000313 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 484022000314 recombination protein RecR; Provisional; Region: PRK13844 484022000315 RecR protein; Region: RecR; pfam02132 484022000316 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 484022000317 putative active site [active] 484022000318 putative metal-binding site [ion binding]; other site 484022000319 tetramer interface [polypeptide binding]; other site 484022000320 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 484022000321 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 484022000322 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 484022000323 Walker A motif; other site 484022000324 ATP binding site [chemical binding]; other site 484022000325 Walker B motif; other site 484022000326 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 484022000327 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 484022000328 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 484022000329 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000330 Integrase core domain; Region: rve; cl01316 484022000331 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484022000332 ligand binding site [chemical binding]; other site 484022000333 ferredoxin; Validated; Region: PRK07118 484022000334 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 484022000335 active site 484022000336 (T/H)XGH motif; other site 484022000337 Domain of unknown function DUF59; Region: DUF59; cl00941 484022000338 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 484022000339 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 484022000340 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 484022000341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000342 catalytic residue [active] 484022000343 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 484022000344 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 484022000345 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 484022000346 Protein of unknown function DUF45; Region: DUF45; cl00636 484022000347 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 484022000348 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 484022000349 active site 484022000350 metal binding site [ion binding]; metal-binding site 484022000351 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 484022000352 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 484022000353 Prephenate dehydratase; Region: PDT; pfam00800 484022000354 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 484022000355 putative L-Phe binding site [chemical binding]; other site 484022000356 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022000357 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022000358 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 484022000359 alanine racemase; Reviewed; Region: alr; PRK00053 484022000360 active site 484022000361 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022000362 dimer interface [polypeptide binding]; other site 484022000363 substrate binding site [chemical binding]; other site 484022000364 catalytic residues [active] 484022000365 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022000366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022000367 Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is...; Region: GST_N_Metaxin_like; cd03080 484022000368 putative C-terminal domain interface [polypeptide binding]; other site 484022000369 putative GSH binding site [chemical binding]; other site 484022000370 putative dimer interface [polypeptide binding]; other site 484022000371 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 484022000372 dimer interface [polypeptide binding]; other site 484022000373 substrate binding pocket (H-site) [chemical binding]; other site 484022000374 GST_C family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its...; Region: GST_C_Metaxin; cd03193 484022000375 putative N-terminal domain interface [polypeptide binding]; other site 484022000376 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 484022000377 Integral membrane protein TerC family; Region: TerC; cl10468 484022000378 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 484022000379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022000380 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 484022000381 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000382 Integrase core domain; Region: rve; cl01316 484022000383 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 484022000384 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000385 Integrase core domain; Region: rve; cl01316 484022000386 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 484022000387 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022000388 Walker A/P-loop; other site 484022000389 ATP binding site [chemical binding]; other site 484022000390 Q-loop/lid; other site 484022000391 ABC transporter signature motif; other site 484022000392 Walker B; other site 484022000393 D-loop; other site 484022000394 H-loop/switch region; other site 484022000395 TOBE domain; Region: TOBE_2; cl01440 484022000396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 484022000397 dimer interface [polypeptide binding]; other site 484022000398 conserved gate region; other site 484022000399 putative PBP binding loops; other site 484022000400 ABC-ATPase subunit interface; other site 484022000401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 484022000402 dimer interface [polypeptide binding]; other site 484022000403 conserved gate region; other site 484022000404 putative PBP binding loops; other site 484022000405 ABC-ATPase subunit interface; other site 484022000406 LysE type translocator; Region: LysE; cl00565 484022000407 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 484022000408 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 484022000409 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 484022000410 Uncharacterized conserved protein [Function unknown]; Region: COG2128 484022000411 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 484022000412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 484022000413 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 484022000414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022000415 nucleotide binding region [chemical binding]; other site 484022000416 ATP-binding site [chemical binding]; other site 484022000417 hypothetical protein; Provisional; Region: PRK10396 484022000418 SEC-C motif; Region: SEC-C; cl12132 484022000419 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484022000420 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 484022000421 FtsH Extracellular; Region: FtsH_ext; pfam06480 484022000422 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 484022000423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022000424 Walker A motif; other site 484022000425 ATP binding site [chemical binding]; other site 484022000426 Walker B motif; other site 484022000427 arginine finger; other site 484022000428 Peptidase family M41; Region: Peptidase_M41; pfam01434 484022000429 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 484022000430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000431 putative substrate translocation pore; other site 484022000432 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 484022000433 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 484022000434 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 484022000435 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 484022000436 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 484022000437 domain; Region: GreA_GreB_N; pfam03449 484022000438 C-term; Region: GreA_GreB; pfam01272 484022000439 Type II transport protein GspH; Region: GspH; pfam12019 484022000440 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 484022000441 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 484022000442 active site 484022000443 dimer interface [polypeptide binding]; other site 484022000444 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 484022000445 dimer interface [polypeptide binding]; other site 484022000446 active site 484022000447 Thiamine pyrophosphokinase; Region: TPK; cd07995 484022000448 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 484022000449 active site 484022000450 dimerization interface [polypeptide binding]; other site 484022000451 thiamine binding site [chemical binding]; other site 484022000452 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 484022000453 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 484022000454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 484022000455 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 484022000456 active site 484022000457 multifunctional aminopeptidase A; Provisional; Region: PRK00913 484022000458 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 484022000459 interface (dimer of trimers) [polypeptide binding]; other site 484022000460 Substrate-binding/catalytic site; other site 484022000461 Zn-binding sites [ion binding]; other site 484022000462 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 484022000463 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 484022000464 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 484022000465 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 484022000466 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 484022000467 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 484022000468 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 484022000469 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 484022000470 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 484022000471 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 484022000472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022000473 Predicted membrane protein [Function unknown]; Region: COG2860 484022000474 UPF0126 domain; Region: UPF0126; pfam03458 484022000475 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 484022000476 active site 484022000477 dinuclear metal binding site [ion binding]; other site 484022000478 dimerization interface [polypeptide binding]; other site 484022000479 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 484022000480 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484022000481 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 484022000482 active site 484022000483 catalytic motif [active] 484022000484 Zn binding site [ion binding]; other site 484022000485 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022000486 FAD binding domain; Region: FAD_binding_4; pfam01565 484022000487 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 484022000488 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 484022000489 Sulfatase; Region: Sulfatase; cl10460 484022000490 seryl-tRNA synthetase; Provisional; Region: PRK05431 484022000491 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 484022000492 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 484022000493 dimer interface [polypeptide binding]; other site 484022000494 active site 484022000495 motif 1; other site 484022000496 motif 2; other site 484022000497 motif 3; other site 484022000498 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022000499 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 484022000500 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 484022000501 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 484022000502 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 484022000503 GTP/Mg2+ binding site [chemical binding]; other site 484022000504 G4 box; other site 484022000505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022000506 G5 box; other site 484022000507 G1 box; other site 484022000508 Walker A/P-loop; other site 484022000509 ATP binding site [chemical binding]; other site 484022000510 Q-loop/lid; other site 484022000511 ABC transporter signature motif; other site 484022000512 Walker B; other site 484022000513 D-loop; other site 484022000514 H-loop/switch region; other site 484022000515 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 484022000516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022000517 Walker A/P-loop; other site 484022000518 ATP binding site [chemical binding]; other site 484022000519 Q-loop/lid; other site 484022000520 ABC transporter signature motif; other site 484022000521 Walker B; other site 484022000522 D-loop; other site 484022000523 H-loop/switch region; other site 484022000524 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000525 Integrase core domain; Region: rve; cl01316 484022000526 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000527 Integrase core domain; Region: rve; cl01316 484022000528 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484022000529 HsdM N-terminal domain; Region: HsdM_N; pfam12161 484022000530 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 484022000531 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 484022000532 MAPEG family; Region: MAPEG; cl09190 484022000533 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484022000534 homotrimer interaction site [polypeptide binding]; other site 484022000535 putative active site [active] 484022000536 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484022000537 Sulfate transporter family; Region: Sulfate_transp; cl00967 484022000538 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 484022000539 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 484022000540 ABC-2 type transporter; Region: ABC2_membrane; cl11417 484022000541 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000542 Integrase core domain; Region: rve; cl01316 484022000543 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484022000544 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 484022000545 Walker A/P-loop; other site 484022000546 ATP binding site [chemical binding]; other site 484022000547 Q-loop/lid; other site 484022000548 ABC transporter signature motif; other site 484022000549 Walker B; other site 484022000550 D-loop; other site 484022000551 H-loop/switch region; other site 484022000552 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484022000553 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 484022000554 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 484022000555 active site 484022000556 catalytic site [active] 484022000557 metal binding site [ion binding]; metal-binding site 484022000558 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 484022000559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000560 putative substrate translocation pore; other site 484022000561 classical (c) SDRs; Region: SDR_c; cd05233 484022000562 NAD(P) binding site [chemical binding]; other site 484022000563 active site 484022000564 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 484022000565 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 484022000566 heme binding site [chemical binding]; other site 484022000567 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 484022000568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 484022000569 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 484022000570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000571 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000572 putative substrate translocation pore; other site 484022000573 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 484022000574 putative substrate binding pocket [chemical binding]; other site 484022000575 trimer interface [polypeptide binding]; other site 484022000576 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 484022000577 MatE; Region: MatE; pfam01554 484022000578 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 484022000579 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 484022000580 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000581 active site 484022000582 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 484022000583 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 484022000584 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000585 active site 484022000586 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000587 Integrase core domain; Region: rve; cl01316 484022000588 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 484022000589 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 484022000590 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 484022000591 putative active site [active] 484022000592 putative substrate binding site [chemical binding]; other site 484022000593 putative cosubstrate binding site; other site 484022000594 catalytic site [active] 484022000595 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 484022000596 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000597 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 484022000598 active site 484022000599 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000600 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 484022000601 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 484022000602 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 484022000603 chitin/cellulose binding site [chemical binding]; other site 484022000604 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 484022000605 chitin/cellulose binding site [chemical binding]; other site 484022000606 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 484022000607 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 484022000608 substrate-cofactor binding pocket; other site 484022000609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000610 catalytic residue [active] 484022000611 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 484022000612 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 484022000613 NAD(P) binding site [chemical binding]; other site 484022000614 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022000615 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 484022000616 substrate binding site [chemical binding]; other site 484022000617 dimer interface [polypeptide binding]; other site 484022000618 Septum formation initiator; Region: DivIC; cl11433 484022000619 enolase; Provisional; Region: eno; PRK00077 484022000620 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 484022000621 dimer interface [polypeptide binding]; other site 484022000622 metal binding site [ion binding]; metal-binding site 484022000623 substrate binding pocket [chemical binding]; other site 484022000624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000626 putative substrate translocation pore; other site 484022000627 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 484022000628 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022000629 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 484022000630 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022000631 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 484022000632 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 484022000633 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 484022000634 TRAM domain; Region: TRAM; cl01282 484022000635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022000636 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 484022000637 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 484022000638 ATP-binding site [chemical binding]; other site 484022000639 Sugar specificity; other site 484022000640 Pyrimidine base specificity; other site 484022000641 NeuB family; Region: NeuB; cl00496 484022000642 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484022000643 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 484022000644 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 484022000645 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 484022000646 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 484022000647 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 484022000648 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 484022000649 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 484022000650 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 484022000651 putative nucleic acid binding region [nucleotide binding]; other site 484022000652 G-X-X-G motif; other site 484022000653 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 484022000654 RNA binding site [nucleotide binding]; other site 484022000655 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 484022000656 16S/18S rRNA binding site [nucleotide binding]; other site 484022000657 S13e-L30e interaction site [polypeptide binding]; other site 484022000658 25S rRNA binding site [nucleotide binding]; other site 484022000659 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 484022000660 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 484022000661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 484022000662 Septum formation initiator; Region: DivIC; cl11433 484022000663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022000664 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 484022000665 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 484022000666 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 484022000667 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 484022000668 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 484022000669 DNA binding site [nucleotide binding] 484022000670 catalytic residue [active] 484022000671 H2TH interface [polypeptide binding]; other site 484022000672 putative catalytic residues [active] 484022000673 turnover-facilitating residue; other site 484022000674 intercalation triad [nucleotide binding]; other site 484022000675 8OG recognition residue [nucleotide binding]; other site 484022000676 putative reading head residues; other site 484022000677 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 484022000678 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 484022000679 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 484022000680 predicted active site [active] 484022000681 catalytic triad [active] 484022000682 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 484022000683 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 484022000684 active site 484022000685 multimer interface [polypeptide binding]; other site 484022000686 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 484022000687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 484022000688 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 484022000689 anchoring element; other site 484022000690 dimer interface [polypeptide binding]; other site 484022000691 ATP binding site [chemical binding]; other site 484022000692 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 484022000693 active site 484022000694 putative metal-binding site [ion binding]; other site 484022000695 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484022000696 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 484022000697 putative active site pocket [active] 484022000698 dimerization interface [polypeptide binding]; other site 484022000699 putative catalytic residue [active] 484022000700 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 484022000701 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 484022000702 FMN binding site [chemical binding]; other site 484022000703 active site 484022000704 catalytic residues [active] 484022000705 substrate binding site [chemical binding]; other site 484022000706 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022000707 TIGR03546 family protein; Region: TIGR03546 484022000708 TIGR03545 family protein; Region: TIGR03545 484022000709 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 484022000710 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022000711 CoA-ligase; Region: Ligase_CoA; pfam00549 484022000712 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 484022000713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022000714 CoA-ligase; Region: Ligase_CoA; pfam00549 484022000715 Cytochrome P450; Region: p450; cl12078 484022000716 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 484022000717 NADP binding site [chemical binding]; other site 484022000718 homodimer interface [polypeptide binding]; other site 484022000719 active site 484022000720 Domain of unknown function DUF20; Region: UPF0118; cl00465 484022000721 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 484022000722 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022000723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000724 putative substrate translocation pore; other site 484022000725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022000726 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (...; Region: Glycosylasparaginase; cd04513 484022000727 active site 484022000728 dimer interface [polypeptide binding]; other site 484022000729 catalytic nucleophile [active] 484022000730 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 484022000731 CutC family; Region: CutC; cl01218 484022000732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 484022000733 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484022000734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 484022000735 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 484022000736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022000737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 484022000738 motif II; other site 484022000739 thioredoxin reductase; Provisional; Region: PRK10262 484022000740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022000741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000742 putative substrate translocation pore; other site 484022000743 H+ Antiporter protein; Region: 2A0121; TIGR00900 484022000744 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 484022000745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 484022000746 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 484022000747 ATP binding site [chemical binding]; other site 484022000748 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 484022000749 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 484022000750 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 484022000751 GTPase RsgA; Reviewed; Region: PRK00098 484022000752 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 484022000753 GTPase/OB domain interface [polypeptide binding]; other site 484022000754 GTPase/Zn-binding domain interface [polypeptide binding]; other site 484022000755 GTP/Mg2+ binding site [chemical binding]; other site 484022000756 G4 box; other site 484022000757 G5 box; other site 484022000758 G1 box; other site 484022000759 Switch I region; other site 484022000760 G2 box; other site 484022000761 G3 box; other site 484022000762 Switch II region; other site 484022000763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022000764 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 484022000765 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022000766 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022000767 Domain of unknown function DUF20; Region: UPF0118; cl00465 484022000768 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 484022000769 DHH family; Region: DHH; pfam01368 484022000770 DHHA1 domain; Region: DHHA1; pfam02272 484022000771 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 484022000772 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 484022000773 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 484022000774 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484022000775 motif 1; other site 484022000776 dimer interface [polypeptide binding]; other site 484022000777 active site 484022000778 motif 2; other site 484022000779 motif 3; other site 484022000780 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022000781 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 484022000782 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 484022000783 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484022000784 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022000785 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 484022000786 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 484022000787 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 484022000788 carboxyltransferase (CT) interaction site; other site 484022000789 biotinylation site [posttranslational modification]; other site 484022000790 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 484022000791 trimer interface [polypeptide binding]; other site 484022000792 active site 484022000793 dimer interface [polypeptide binding]; other site 484022000794 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 484022000795 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 484022000796 active site 484022000797 metal binding site [ion binding]; metal-binding site 484022000798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022000799 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 484022000800 SurA N-terminal domain; Region: SurA_N; pfam09312 484022000801 PPIC-type PPIASE domain; Region: Rotamase; cl08278 484022000802 PPIC-type PPIASE domain; Region: Rotamase; cl08278 484022000803 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 484022000804 Organic solvent tolerance protein; Region: OstA_C; pfam04453 484022000805 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 484022000806 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 484022000807 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022000808 active site 484022000809 HIGH motif; other site 484022000810 nucleotide binding site [chemical binding]; other site 484022000811 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 484022000812 KMSK motif region; other site 484022000813 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484022000814 tRNA binding surface [nucleotide binding]; other site 484022000815 anticodon binding site; other site 484022000816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022000817 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022000818 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 484022000819 active site/substrate binding site [active] 484022000820 tetramer interface [polypeptide binding]; other site 484022000821 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 484022000822 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 484022000823 dimer interface [polypeptide binding]; other site 484022000824 active site 484022000825 Schiff base residues; other site 484022000826 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 484022000827 DNA polymerase III subunit delta'; Validated; Region: PRK06871 484022000828 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022000829 C terminal; Region: DNApol3-delta_C; pfam09115 484022000830 putative inner membrane peptidase; Provisional; Region: PRK11778 484022000831 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 484022000832 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 484022000833 tandem repeat interface [polypeptide binding]; other site 484022000834 oligomer interface [polypeptide binding]; other site 484022000835 active site residues [active] 484022000836 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022000837 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484022000838 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186 484022000839 dimer interface [polypeptide binding]; other site 484022000840 N-terminal domain interface [polypeptide binding]; other site 484022000841 DsrC like protein; Region: DsrC; cl01101 484022000842 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 484022000843 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 484022000844 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 484022000845 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 484022000846 Ligand binding site [chemical binding]; other site 484022000847 Putative Catalytic site [active] 484022000848 DXD motif; other site 484022000849 YdjC-like protein; Region: YdjC; cl01344 484022000850 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 484022000851 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 484022000852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022000853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022000854 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 484022000855 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 484022000856 Mg++ binding site [ion binding]; other site 484022000857 putative catalytic motif [active] 484022000858 putative substrate binding site [chemical binding]; other site 484022000859 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 484022000860 active site 484022000861 metal-binding site [ion binding] 484022000862 nucleotide-binding site [chemical binding]; other site 484022000863 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 484022000864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022000865 active site 484022000866 HIGH motif; other site 484022000867 nucleotide binding site [chemical binding]; other site 484022000868 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 484022000869 KMSKS motif; other site 484022000870 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 484022000871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022000872 ABC transporter ATPase component; Reviewed; Region: PRK11147 484022000873 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 484022000874 Walker A/P-loop; other site 484022000875 ATP binding site [chemical binding]; other site 484022000876 Q-loop/lid; other site 484022000877 ABC transporter signature motif; other site 484022000878 Walker B; other site 484022000879 D-loop; other site 484022000880 H-loop/switch region; other site 484022000881 ABC transporter; Region: ABC_tran_2; pfam12848 484022000882 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 484022000883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000884 putative substrate translocation pore; other site 484022000885 Fusaric acid resistance protein family; Region: FUSC; pfam04632 484022000886 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022000887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000888 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 484022000889 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 484022000890 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 484022000891 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 484022000892 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022000893 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022000894 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022000895 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000896 Integrase core domain; Region: rve; cl01316 484022000897 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 484022000898 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 484022000899 putative active site [active] 484022000900 putative metal binding site [ion binding]; other site 484022000901 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 484022000902 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 484022000903 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 484022000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022000906 putative substrate translocation pore; other site 484022000907 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 484022000908 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 484022000909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000910 catalytic residue [active] 484022000911 homoserine kinase; Provisional; Region: PRK01212 484022000912 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 484022000913 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 484022000914 putative catalytic residues [active] 484022000915 nucleotide binding site [chemical binding]; other site 484022000916 aspartate binding site [chemical binding]; other site 484022000917 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 484022000918 dimer interface [polypeptide binding]; other site 484022000919 putative threonine allosteric regulatory site; other site 484022000920 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 484022000921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022000922 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 484022000923 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 484022000924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022000925 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 484022000926 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022000927 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 484022000928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022000929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022000930 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 484022000931 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022000932 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 484022000933 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022000934 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022000935 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 484022000936 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 484022000937 dimer interface [polypeptide binding]; other site 484022000938 motif 1; other site 484022000939 active site 484022000940 motif 2; other site 484022000941 motif 3; other site 484022000942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022000943 Coenzyme A binding pocket [chemical binding]; other site 484022000944 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 484022000945 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022000946 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 484022000947 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000948 Integrase core domain; Region: rve; cl01316 484022000949 glycogen synthase; Provisional; Region: glgA; PRK00654 484022000950 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 484022000951 ADP-binding pocket [chemical binding]; other site 484022000952 homodimer interface [polypeptide binding]; other site 484022000953 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 484022000954 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 484022000955 ligand binding site [chemical binding]; other site 484022000956 oligomer interface [polypeptide binding]; other site 484022000957 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 484022000958 dimer interface [polypeptide binding]; other site 484022000959 N-terminal domain interface [polypeptide binding]; other site 484022000960 sulfate 1 binding site; other site 484022000961 phosphoglucomutase; Region: PLN02307 484022000962 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one...; Region: PGM1; cd03085 484022000963 substrate binding site [chemical binding]; other site 484022000964 dimer interface [polypeptide binding]; other site 484022000965 active site 484022000966 metal binding site [ion binding]; metal-binding site 484022000967 glycogen branching enzyme; Provisional; Region: PRK12313 484022000968 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 484022000969 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 484022000970 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 484022000971 pullulanase, type I; Region: pulA_typeI; TIGR02104 484022000972 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 484022000973 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 484022000974 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484022000975 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484022000976 shikimate binding site; other site 484022000977 NAD(P) binding site [chemical binding]; other site 484022000978 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 484022000979 conserved cys residue [active] 484022000980 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 484022000981 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484022000982 homodimer interface [polypeptide binding]; other site 484022000983 substrate-cofactor binding pocket; other site 484022000984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000985 catalytic residue [active] 484022000986 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022000987 active site 484022000988 catalytic triad [active] 484022000989 oxyanion hole [active] 484022000990 Predicted helicase [General function prediction only]; Region: COG4889 484022000991 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 484022000992 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 484022000993 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 484022000994 tetramer interface [polypeptide binding]; other site 484022000995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000996 catalytic residue [active] 484022000997 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 484022000998 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 484022000999 tetramer interface [polypeptide binding]; other site 484022001000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001001 catalytic residue [active] 484022001002 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 484022001003 lipoyl attachment site [posttranslational modification]; other site 484022001004 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 484022001005 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 484022001006 lysine decarboxylase LdcC; Provisional; Region: PRK15399 484022001007 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 484022001008 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 484022001009 homodimer interface [polypeptide binding]; other site 484022001010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001011 catalytic residue [active] 484022001012 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 484022001013 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 484022001014 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 484022001015 Walker A/P-loop; other site 484022001016 ATP binding site [chemical binding]; other site 484022001017 Q-loop/lid; other site 484022001018 ABC transporter signature motif; other site 484022001019 Walker B; other site 484022001020 D-loop; other site 484022001021 H-loop/switch region; other site 484022001022 LolC/E family; Region: lolCE; TIGR02212 484022001023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484022001024 FtsX-like permease family; Region: FtsX; pfam02687 484022001025 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 484022001026 active site 484022001027 catalytic residues [active] 484022001028 metal binding site [ion binding]; metal-binding site 484022001029 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484022001030 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022001031 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 484022001032 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 484022001033 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 484022001034 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022001035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022001036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001037 putative substrate translocation pore; other site 484022001038 lytic murein transglycosylase; Provisional; Region: PRK11619 484022001039 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 484022001040 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022001041 catalytic residue [active] 484022001042 lytic murein transglycosylase; Provisional; Region: PRK11619 484022001043 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 484022001044 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022001045 catalytic residue [active] 484022001046 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484022001047 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 484022001048 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 484022001049 CAP-like domain; other site 484022001050 Active site [active] 484022001051 primary dimer interface [polypeptide binding]; other site 484022001052 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 484022001053 putative homodimer interface [polypeptide binding]; other site 484022001054 putative active site [active] 484022001055 catalytic site [active] 484022001056 methionine aminopeptidase; Reviewed; Region: PRK07281 484022001057 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 484022001058 active site 484022001059 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 484022001060 DNA-binding site [nucleotide binding]; DNA binding site 484022001061 RNA-binding motif; other site 484022001062 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 484022001063 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484022001064 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 484022001065 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 484022001066 glutaminase active site [active] 484022001067 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 484022001068 dimer interface [polypeptide binding]; other site 484022001069 active site 484022001070 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484022001071 dimer interface [polypeptide binding]; other site 484022001072 active site 484022001073 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 484022001074 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 484022001075 Substrate binding site [chemical binding]; other site 484022001076 Mg++ binding site [ion binding]; other site 484022001077 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 484022001078 active site 484022001079 substrate binding site [chemical binding]; other site 484022001080 CoA binding site [chemical binding]; other site 484022001081 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 484022001082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022001083 active site 484022001084 nucleotide binding site [chemical binding]; other site 484022001085 HIGH motif; other site 484022001086 KMSKS motif; other site 484022001087 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 484022001088 nudix motif; other site 484022001089 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 484022001090 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 484022001091 active site 484022001092 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001093 Integrase core domain; Region: rve; cl01316 484022001094 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 484022001095 putative substrate binding region [chemical binding]; other site 484022001096 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 484022001097 Transposase domain (DUF772); Region: DUF772; cl12084 484022001098 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 484022001099 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 484022001100 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 484022001101 active site 484022001102 HIGH motif; other site 484022001103 KMSKS motif; other site 484022001104 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 484022001105 tRNA binding surface [nucleotide binding]; other site 484022001106 anticodon binding site; other site 484022001107 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 484022001108 dimer interface [polypeptide binding]; other site 484022001109 putative tRNA-binding site [nucleotide binding]; other site 484022001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001111 D-galactonate transporter; Region: 2A0114; TIGR00893 484022001112 putative substrate translocation pore; other site 484022001113 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 484022001114 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 484022001115 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 484022001116 Intracellular septation protein A; Region: IspA; cl01098 484022001117 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 484022001118 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 484022001119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022001120 S-adenosylmethionine binding site [chemical binding]; other site 484022001121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 484022001122 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 484022001123 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 484022001124 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 484022001125 nucleotide binding site/active site [active] 484022001126 HIT family signature motif; other site 484022001127 catalytic residue [active] 484022001128 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 484022001129 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 484022001130 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 484022001131 FAD binding domain; Region: FAD_binding_4; pfam01565 484022001132 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 484022001133 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 484022001134 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 484022001135 putative active site [active] 484022001136 GTP-binding protein Der; Reviewed; Region: PRK00093 484022001137 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 484022001138 G1 box; other site 484022001139 GTP/Mg2+ binding site [chemical binding]; other site 484022001140 Switch I region; other site 484022001141 G2 box; other site 484022001142 Switch II region; other site 484022001143 G3 box; other site 484022001144 G4 box; other site 484022001145 G5 box; other site 484022001146 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 484022001147 G1 box; other site 484022001148 GTP/Mg2+ binding site [chemical binding]; other site 484022001149 Switch I region; other site 484022001150 G2 box; other site 484022001151 G3 box; other site 484022001152 Switch II region; other site 484022001153 G4 box; other site 484022001154 G5 box; other site 484022001155 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022001156 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022001157 malate dehydrogenase; Provisional; Region: PRK13529 484022001158 Malic enzyme, N-terminal domain; Region: malic; pfam00390 484022001159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022001160 NAD(P) binding pocket [chemical binding]; other site 484022001161 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 484022001162 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 484022001163 active site 484022001164 Riboflavin kinase; Region: Flavokinase; pfam01687 484022001165 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 484022001166 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022001167 active site 484022001168 HIGH motif; other site 484022001169 nucleotide binding site [chemical binding]; other site 484022001170 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 484022001171 active site 484022001172 KMSKS motif; other site 484022001173 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 484022001174 tRNA binding surface [nucleotide binding]; other site 484022001175 anticodon binding site; other site 484022001176 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 484022001177 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 484022001178 lipoprotein signal peptidase; Provisional; Region: PRK14787 484022001179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022001180 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 484022001181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484022001182 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022001183 active site 484022001184 catalytic triad [active] 484022001185 oxyanion hole [active] 484022001186 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 484022001187 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 484022001188 catalytic triad [active] 484022001189 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 484022001190 ParB-like nuclease domain; Region: ParBc; cl02129 484022001191 KorB domain; Region: KorB; pfam08535 484022001192 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 484022001193 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 484022001194 P-loop; other site 484022001195 Magnesium ion binding site [ion binding]; other site 484022001196 DNA topoisomerase I; Validated; Region: PRK06599 484022001197 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 484022001198 active site 484022001199 interdomain interaction site; other site 484022001200 putative metal-binding site [ion binding]; other site 484022001201 nucleotide binding site [chemical binding]; other site 484022001202 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 484022001203 domain I; other site 484022001204 DNA binding groove [nucleotide binding] 484022001205 phosphate binding site [ion binding]; other site 484022001206 domain II; other site 484022001207 domain III; other site 484022001208 nucleotide binding site [chemical binding]; other site 484022001209 catalytic site [active] 484022001210 domain IV; other site 484022001211 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 484022001212 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 484022001213 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 484022001214 O-Antigen ligase; Region: Wzy_C; cl04850 484022001215 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 484022001216 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as...; Region: Mth938-like; cd00248 484022001217 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 484022001218 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 484022001219 active site 484022001220 Zn binding site [ion binding]; other site 484022001221 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 484022001222 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 484022001223 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022001224 AIR carboxylase; Region: AIRC; cl00310 484022001225 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 484022001226 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 484022001227 active site 484022001228 substrate binding site [chemical binding]; other site 484022001229 cosubstrate binding site; other site 484022001230 catalytic site [active] 484022001231 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 484022001232 active site 484022001233 ATP binding site [chemical binding]; other site 484022001234 substrate binding site [chemical binding]; other site 484022001235 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 484022001236 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 484022001237 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022001238 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 484022001239 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 484022001240 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 484022001241 dimerization interface [polypeptide binding]; other site 484022001242 putative ATP binding site [chemical binding]; other site 484022001243 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 484022001244 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 484022001245 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 484022001246 homodimer interface [polypeptide binding]; other site 484022001247 NADP binding site [chemical binding]; other site 484022001248 substrate binding site [chemical binding]; other site 484022001249 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 484022001250 active site 484022001251 putative major pilin subunit; Provisional; Region: PRK10574 484022001252 Pilin (bacterial filament); Region: Pilin; pfam00114 484022001253 recombination and repair protein; Provisional; Region: PRK10869 484022001254 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 484022001255 Walker A/P-loop; other site 484022001256 ATP binding site [chemical binding]; other site 484022001257 Q-loop/lid; other site 484022001258 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 484022001259 ABC transporter signature motif; other site 484022001260 Walker B; other site 484022001261 D-loop; other site 484022001262 H-loop/switch region; other site 484022001263 aspartate aminotransferase; Provisional; Region: PRK08361 484022001264 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022001265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001266 homodimer interface [polypeptide binding]; other site 484022001267 catalytic residue [active] 484022001268 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 484022001269 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 484022001270 substrate binding site [chemical binding]; other site 484022001271 catalytic Zn binding site [ion binding]; other site 484022001272 NAD binding site [chemical binding]; other site 484022001273 structural Zn binding site [ion binding]; other site 484022001274 dimer interface [polypeptide binding]; other site 484022001275 Cupin domain; Region: Cupin_2; cl09118 484022001276 ethanolamine permease; Region: 2A0305; TIGR00908 484022001277 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022001278 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 484022001279 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 484022001280 E-class dimer interface [polypeptide binding]; other site 484022001281 P-class dimer interface [polypeptide binding]; other site 484022001282 active site 484022001283 Cu2+ binding site [ion binding]; other site 484022001284 Zn2+ binding site [ion binding]; other site 484022001285 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001286 Integrase core domain; Region: rve; cl01316 484022001287 SelR domain; Region: SelR; cl00369 484022001288 PQ loop repeat; Region: PQ-loop; cl12056 484022001289 PQ loop repeat; Region: PQ-loop; cl12056 484022001290 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 484022001291 Tetramer interface [polypeptide binding]; other site 484022001292 Active site [active] 484022001293 FMN-binding site [chemical binding]; other site 484022001294 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484022001295 PilZ domain; Region: PilZ; cl01260 484022001296 DNA repair protein RadA; Provisional; Region: PRK11823 484022001297 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 484022001298 Walker A motif/ATP binding site; other site 484022001299 ATP binding site [chemical binding]; other site 484022001300 Walker B motif; other site 484022001301 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 484022001302 Colicin V production protein; Region: Colicin_V; cl00567 484022001303 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 484022001304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022001305 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 484022001306 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 484022001307 putative active site [active] 484022001308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022001309 putative DNA binding site [nucleotide binding]; other site 484022001310 dimerization interface [polypeptide binding]; other site 484022001311 putative Zn2+ binding site [ion binding]; other site 484022001312 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 484022001313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484022001314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022001315 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 484022001316 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 484022001317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022001318 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 484022001319 putative dimerization interface [polypeptide binding]; other site 484022001320 LemA family; Region: LemA; cl00742 484022001321 Peptidase family M48; Region: Peptidase_M48; cl12018 484022001322 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 484022001323 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 484022001324 ribonuclease PH; Reviewed; Region: rph; PRK00173 484022001325 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 484022001326 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 484022001327 Chorismate lyase; Region: Chor_lyase; cl01230 484022001328 UbiA prenyltransferase family; Region: UbiA; cl00337 484022001329 Protein of unknown function, DUF393; Region: DUF393; cl01136 484022001330 Protein of unknown function (DUF423); Region: DUF423; cl01008 484022001331 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 484022001332 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 484022001333 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484022001334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 484022001335 YheO-like PAS domain; Region: PAS_6; pfam08348 484022001336 Membrane transport protein; Region: Mem_trans; cl09117 484022001337 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 484022001338 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 484022001339 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 484022001340 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 484022001341 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 484022001342 DNA photolyase; Region: DNA_photolyase; pfam00875 484022001343 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 484022001344 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 484022001345 short chain dehydrogenase; Provisional; Region: PRK06924 484022001346 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 484022001347 NADP binding site [chemical binding]; other site 484022001348 homodimer interface [polypeptide binding]; other site 484022001349 active site 484022001350 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 484022001351 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 484022001352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 484022001353 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484022001354 ligand binding site [chemical binding]; other site 484022001355 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 484022001356 TolB amino-terminal domain; Region: TolB_N; pfam04052 484022001357 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 484022001358 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 484022001359 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 484022001360 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 484022001361 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 484022001362 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 484022001363 homotrimer interaction site [polypeptide binding]; other site 484022001364 active site 484022001365 LytB protein; Region: LYTB; cl00507 484022001366 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 484022001367 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 484022001368 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 484022001369 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484022001370 ligand binding site [chemical binding]; other site 484022001371 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001372 Integrase core domain; Region: rve; cl01316 484022001373 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 484022001374 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 484022001375 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 484022001376 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 484022001377 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 484022001378 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 484022001379 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 484022001380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022001381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001382 homodimer interface [polypeptide binding]; other site 484022001383 catalytic residue [active] 484022001384 Sulfate transporter family; Region: Sulfate_transp; cl00967 484022001385 tail fiber protein; Region: PHA00430 484022001386 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 484022001387 catalytic residue [active] 484022001388 MarC family integral membrane protein; Region: MarC; cl00919 484022001389 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 484022001390 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 484022001391 nudix motif; other site 484022001392 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 484022001393 putative metal binding site [ion binding]; other site 484022001394 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 484022001395 Fumarase C-terminus; Region: Fumerase_C; cl00795 484022001396 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 484022001397 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 484022001398 ssDNA binding site; other site 484022001399 generic binding surface II; other site 484022001400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022001401 ATP binding site [chemical binding]; other site 484022001402 putative Mg++ binding site [ion binding]; other site 484022001403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022001404 nucleotide binding region [chemical binding]; other site 484022001405 ATP-binding site [chemical binding]; other site 484022001406 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 484022001407 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 484022001408 septum formation inhibitor; Reviewed; Region: minC; PRK04804 484022001409 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 484022001410 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 484022001411 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 484022001412 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 484022001413 Switch I; other site 484022001414 Switch II; other site 484022001415 Septum formation topological specificity factor MinE; Region: MinE; cl00538 484022001416 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 484022001417 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 484022001418 Walker A/P-loop; other site 484022001419 ATP binding site [chemical binding]; other site 484022001420 Q-loop/lid; other site 484022001421 ABC transporter signature motif; other site 484022001422 Walker B; other site 484022001423 D-loop; other site 484022001424 H-loop/switch region; other site 484022001425 Domain of unknown function DUF140; Region: DUF140; cl00510 484022001426 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 484022001427 mce related protein; Region: MCE; cl03606 484022001428 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 484022001429 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 484022001430 anti sigma factor interaction site; other site 484022001431 regulatory phosphorylation site [posttranslational modification]; other site 484022001432 BolA-like protein; Region: BolA; cl00386 484022001433 VacJ like lipoprotein; Region: VacJ; cl01073 484022001434 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 484022001435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022001436 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022001437 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022001438 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 484022001439 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 484022001440 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022001441 catalytic residue [active] 484022001442 Transposase, Mutator family; Region: Transposase_mut; pfam00872 484022001443 MULE transposase domain; Region: MULE; pfam10551 484022001444 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 484022001445 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but...; Region: chitinase_glyco_hydro_19; cd00325 484022001446 putative sugar binding site [chemical binding]; other site 484022001447 catalytic residues [active] 484022001448 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484022001449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022001450 Coenzyme A binding pocket [chemical binding]; other site 484022001451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022001453 putative substrate translocation pore; other site 484022001454 HemK family putative methylases; Region: hemK_fam; TIGR00536 484022001455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022001456 S-adenosylmethionine binding site [chemical binding]; other site 484022001457 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 484022001458 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484022001459 active site 484022001460 HIGH motif; other site 484022001461 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484022001462 KMSKS motif; other site 484022001463 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 484022001464 tRNA binding surface [nucleotide binding]; other site 484022001465 anticodon binding site; other site 484022001466 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 484022001467 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 484022001468 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 484022001469 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 484022001470 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 484022001471 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 484022001472 Domain of unknown function DUF21; Region: DUF21; pfam01595 484022001473 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484022001474 Transporter associated domain; Region: CorC_HlyC; pfam03471 484022001475 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 484022001476 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 484022001477 DXD motif; other site 484022001478 Sodium:solute symporter family; Region: SSF; cl00456 484022001479 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 484022001480 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 484022001481 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 484022001482 putative active site [active] 484022001483 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 484022001484 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022001485 Amino acid permease; Region: AA_permease; pfam00324 484022001486 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 484022001487 active site 484022001488 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 484022001489 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022001490 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 484022001491 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 484022001492 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 484022001493 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 484022001494 Cation transport protein; Region: TrkH; cl10514 484022001495 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl00174 484022001496 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 484022001497 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 484022001498 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 484022001499 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 484022001500 FAD binding pocket [chemical binding]; other site 484022001501 FAD binding motif [chemical binding]; other site 484022001502 phosphate binding motif [ion binding]; other site 484022001503 beta-alpha-beta structure motif; other site 484022001504 NAD binding pocket [chemical binding]; other site 484022001505 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 484022001506 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 484022001507 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 484022001508 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 484022001509 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 484022001510 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 484022001511 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 484022001512 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 484022001513 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 484022001514 active site 484022001515 multimer interface [polypeptide binding]; other site 484022001516 CTP synthetase; Validated; Region: pyrG; PRK05380 484022001517 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 484022001518 Catalytic site [active] 484022001519 Active site [active] 484022001520 UTP binding site [chemical binding]; other site 484022001521 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 484022001522 active site 484022001523 putative oxyanion hole; other site 484022001524 catalytic triad [active] 484022001525 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 484022001526 Predicted membrane protein [Function unknown]; Region: COG1288 484022001527 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 484022001528 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 484022001529 ANP binding site [chemical binding]; other site 484022001530 Substrate Binding Site II [chemical binding]; other site 484022001531 Substrate Binding Site I [chemical binding]; other site 484022001532 Lyase; Region: Lyase_1; pfam00206 484022001533 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 484022001534 tetramer interface [polypeptide binding]; other site 484022001535 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 484022001536 arginine repressor; Region: argR_whole; TIGR01529 484022001537 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 484022001538 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 484022001539 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 484022001540 inhibitor-cofactor binding pocket; inhibition site 484022001541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001542 catalytic residue [active] 484022001543 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 484022001544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022001545 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 484022001546 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 484022001547 heterotetramer interface [polypeptide binding]; other site 484022001548 active site pocket [active] 484022001549 cleavage site 484022001550 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 484022001551 nucleotide binding site [chemical binding]; other site 484022001552 N-acetyl-L-glutamate binding site [chemical binding]; other site 484022001553 ornithine carbamoyltransferase; Provisional; Region: PRK00779 484022001554 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484022001555 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484022001556 heat shock protein 90; Provisional; Region: PRK05218 484022001557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 484022001558 Ion transport protein; Region: Ion_trans; pfam00520 484022001559 Ion channel; Region: Ion_trans_2; cl11596 484022001560 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 484022001561 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 484022001562 alphaNTD homodimer interface [polypeptide binding]; other site 484022001563 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 484022001564 alphaNTD - beta interaction site [polypeptide binding]; other site 484022001565 alphaNTD - beta' interaction site [polypeptide binding]; other site 484022001566 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 484022001567 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 484022001568 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 484022001569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022001570 RNA binding surface [nucleotide binding]; other site 484022001571 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 484022001572 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 484022001573 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 484022001574 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 484022001575 SecY translocase; Region: SecY; pfam00344 484022001576 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 484022001577 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 484022001578 23S rRNA binding site [nucleotide binding]; other site 484022001579 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 484022001580 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 484022001581 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 484022001582 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 484022001583 23S rRNA interface [nucleotide binding]; other site 484022001584 L21e interface [polypeptide binding]; other site 484022001585 5S rRNA interface [nucleotide binding]; other site 484022001586 L27 interface [polypeptide binding]; other site 484022001587 L5 interface [polypeptide binding]; other site 484022001588 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 484022001589 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484022001590 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484022001591 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 484022001592 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 484022001593 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 484022001594 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 484022001595 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 484022001596 KOW motif; Region: KOW; cl00354 484022001597 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 484022001598 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 484022001599 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 484022001600 23S rRNA interface [nucleotide binding]; other site 484022001601 putative translocon interaction site; other site 484022001602 signal recognition particle (SRP54) interaction site; other site 484022001603 L23 interface [polypeptide binding]; other site 484022001604 trigger factor interaction site; other site 484022001605 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 484022001606 23S rRNA interface [nucleotide binding]; other site 484022001607 5S rRNA interface [nucleotide binding]; other site 484022001608 putative antibiotic binding site [chemical binding]; other site 484022001609 L25 interface [polypeptide binding]; other site 484022001610 L27 interface [polypeptide binding]; other site 484022001611 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 484022001612 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 484022001613 G-X-X-G motif; other site 484022001614 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 484022001615 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 484022001616 putative translocon binding site; other site 484022001617 protein-rRNA interface [nucleotide binding]; other site 484022001618 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 484022001619 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 484022001620 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 484022001621 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 484022001622 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 484022001623 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 484022001624 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 484022001625 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 484022001626 elongation factor G; Reviewed; Region: PRK00007 484022001627 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 484022001628 G1 box; other site 484022001629 putative GEF interaction site [polypeptide binding]; other site 484022001630 GTP/Mg2+ binding site [chemical binding]; other site 484022001631 Switch I region; other site 484022001632 G2 box; other site 484022001633 G3 box; other site 484022001634 Switch II region; other site 484022001635 G4 box; other site 484022001636 G5 box; other site 484022001637 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 484022001638 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 484022001639 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 484022001640 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 484022001641 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 484022001642 S17 interaction site [polypeptide binding]; other site 484022001643 S8 interaction site; other site 484022001644 16S rRNA interaction site [nucleotide binding]; other site 484022001645 streptomycin interaction site [chemical binding]; other site 484022001646 23S rRNA interaction site [nucleotide binding]; other site 484022001647 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 484022001648 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 484022001649 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484022001650 trimer interface [polypeptide binding]; other site 484022001651 active site 484022001652 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 484022001653 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 484022001654 catalytic residue [active] 484022001655 putative FPP diphosphate binding site; other site 484022001656 putative FPP binding hydrophobic cleft; other site 484022001657 dimer interface [polypeptide binding]; other site 484022001658 putative IPP diphosphate binding site; other site 484022001659 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 484022001660 hinge region; other site 484022001661 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 484022001662 putative nucleotide binding site [chemical binding]; other site 484022001663 uridine monophosphate binding site [chemical binding]; other site 484022001664 homohexameric interface [polypeptide binding]; other site 484022001665 elongation factor Ts; Provisional; Region: tsf; PRK09377 484022001666 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 484022001667 Elongation factor TS; Region: EF_TS; pfam00889 484022001668 Elongation factor TS; Region: EF_TS; pfam00889 484022001669 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 484022001670 rRNA interaction site [nucleotide binding]; other site 484022001671 S8 interaction site; other site 484022001672 putative laminin-1 binding site; other site 484022001673 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 484022001674 folate binding site [chemical binding]; other site 484022001675 NADP+ binding site [chemical binding]; other site 484022001676 cysteine synthases; Region: cysKM; TIGR01136 484022001677 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 484022001678 dimer interface [polypeptide binding]; other site 484022001679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001680 catalytic residue [active] 484022001681 serine O-acetyltransferase; Region: cysE; TIGR01172 484022001682 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 484022001683 trimer interface [polypeptide binding]; other site 484022001684 active site 484022001685 substrate binding site [chemical binding]; other site 484022001686 CoA binding site [chemical binding]; other site 484022001687 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 484022001688 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484022001689 HIGH motif; other site 484022001690 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484022001691 active site 484022001692 KMSKS motif; other site 484022001693 fumarate hydratase; Reviewed; Region: fumC; PRK00485 484022001694 Class II fumarases; Region: Fumarase_classII; cd01362 484022001695 active site 484022001696 tetramer interface [polypeptide binding]; other site 484022001697 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 484022001698 dimer interface [polypeptide binding]; other site 484022001699 FMN binding site [chemical binding]; other site 484022001700 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 484022001701 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 484022001702 phosphate binding site [ion binding]; other site 484022001703 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 484022001704 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 484022001705 putative catalytic cysteine [active] 484022001706 gamma-glutamyl kinase; Provisional; Region: PRK05429 484022001707 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 484022001708 nucleotide binding site [chemical binding]; other site 484022001709 homotetrameric interface [polypeptide binding]; other site 484022001710 putative phosphate binding site [ion binding]; other site 484022001711 putative allosteric binding site; other site 484022001712 PUA domain; Region: PUA; cl00607 484022001713 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 484022001714 nudix motif; other site 484022001715 phosphoenolpyruvate carboxylase; Provisional; Region: PTZ00398 484022001716 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 484022001717 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 484022001718 Fic/DOC family; Region: Fic; cl00960 484022001719 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 484022001720 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 484022001721 HIGH motif; other site 484022001722 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 484022001723 active site 484022001724 KMSKS motif; other site 484022001725 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 484022001726 tRNA binding surface [nucleotide binding]; other site 484022001727 anticodon binding site; other site 484022001728 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 484022001729 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 484022001730 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 484022001731 putative substrate binding pocket [chemical binding]; other site 484022001732 AC domain interface; other site 484022001733 catalytic triad [active] 484022001734 AB domain interface; other site 484022001735 interchain disulfide; other site 484022001736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 484022001737 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 484022001738 metal ion-dependent adhesion site (MIDAS); other site 484022001739 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 484022001740 metal ion-dependent adhesion site (MIDAS); other site 484022001741 Protein of unknown function DUF58; Region: DUF58; pfam01882 484022001742 MoxR-like ATPases [General function prediction only]; Region: COG0714 484022001743 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022001744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022001745 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022001746 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 484022001747 dimer interface [polypeptide binding]; other site 484022001748 pyridoxal binding site [chemical binding]; other site 484022001749 ATP binding site [chemical binding]; other site 484022001750 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 484022001751 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 484022001752 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 484022001753 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 484022001754 trimer interface [polypeptide binding]; other site 484022001755 active site 484022001756 UDP-GlcNAc binding site [chemical binding]; other site 484022001757 lipid binding site [chemical binding]; lipid-binding site 484022001758 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 484022001759 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 484022001760 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 484022001761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 484022001762 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484022001763 substrate binding pocket [chemical binding]; other site 484022001764 membrane-bound complex binding site; other site 484022001765 hinge residues; other site 484022001766 primosome assembly protein PriA; Validated; Region: PRK05580 484022001767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022001768 ATP binding site [chemical binding]; other site 484022001769 putative Mg++ binding site [ion binding]; other site 484022001770 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 484022001771 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 484022001772 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 484022001773 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 484022001774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022001776 putative substrate translocation pore; other site 484022001777 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 484022001778 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 484022001779 intersubunit interface [polypeptide binding]; other site 484022001780 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 484022001781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022001782 Walker A/P-loop; other site 484022001783 ATP binding site [chemical binding]; other site 484022001784 Q-loop/lid; other site 484022001785 ABC transporter signature motif; other site 484022001786 Walker B; other site 484022001787 D-loop; other site 484022001788 H-loop/switch region; other site 484022001789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 484022001790 ABC-ATPase subunit interface; other site 484022001791 dimer interface [polypeptide binding]; other site 484022001792 putative PBP binding regions; other site 484022001793 Dienelactone hydrolase family; Region: DLH; pfam01738 484022001794 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 484022001795 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 484022001796 adenylosuccinate synthetase; Provisional; Region: PRK01117 484022001797 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 484022001798 GDP-binding site [chemical binding]; other site 484022001799 ACT binding site; other site 484022001800 IMP binding site; other site 484022001801 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 484022001802 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 484022001803 purine monophosphate binding site [chemical binding]; other site 484022001804 dimer interface [polypeptide binding]; other site 484022001805 putative catalytic residues [active] 484022001806 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 484022001807 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 484022001808 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022001809 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022001810 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 484022001811 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 484022001812 DNA polymerase III, delta subunit; Region: holA; TIGR01128 484022001813 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 484022001814 glutamine synthetase; Region: PLN02284 484022001815 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 484022001816 Glutaminase; Region: Glutaminase; cl00907 484022001817 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 484022001818 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 484022001819 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 484022001820 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 484022001821 dimer interface [polypeptide binding]; other site 484022001822 putative anticodon binding site; other site 484022001823 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 484022001824 motif 1; other site 484022001825 active site 484022001826 motif 2; other site 484022001827 motif 3; other site 484022001828 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 484022001829 peptide chain release factor 2; Validated; Region: prfB; PRK00578 484022001830 RF-1 domain; Region: RF-1; cl02875 484022001831 RF-1 domain; Region: RF-1; cl02875 484022001832 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 484022001833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022001834 Walker A motif; other site 484022001835 ATP binding site [chemical binding]; other site 484022001836 Walker B motif; other site 484022001837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022001838 arginine finger; other site 484022001839 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 484022001840 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 484022001841 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 484022001842 cell division protein FtsZ; Validated; Region: PRK09330 484022001843 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 484022001844 nucleotide binding site [chemical binding]; other site 484022001845 SulA interaction site; other site 484022001846 cell division protein FtsA; Region: ftsA; TIGR01174 484022001847 Cell division protein FtsA; Region: FtsA; cl11496 484022001848 Cell division protein FtsA; Region: FtsA; cl11496 484022001849 Cell division protein FtsQ; Region: FtsQ; pfam03799 484022001850 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 484022001851 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 484022001852 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022001853 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 484022001854 nucleoside/Zn binding site; other site 484022001855 dimer interface [polypeptide binding]; other site 484022001856 catalytic motif [active] 484022001857 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 484022001858 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 484022001859 RNA binding site [nucleotide binding]; other site 484022001860 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 484022001861 RNA binding site [nucleotide binding]; other site 484022001862 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 484022001863 RNA binding site [nucleotide binding]; other site 484022001864 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 484022001865 RNA binding site [nucleotide binding]; other site 484022001866 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 484022001867 RNA binding site [nucleotide binding]; other site 484022001868 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 484022001869 RNA binding site [nucleotide binding]; other site 484022001870 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 484022001871 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 484022001872 putative acyl-acceptor binding pocket; other site 484022001873 Competence protein; Region: Competence; cl00471 484022001874 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484022001875 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001876 Integrase core domain; Region: rve; cl01316 484022001877 Competence protein; Region: Competence; cl00471 484022001878 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 484022001879 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022001880 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484022001881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022001882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 484022001883 Coenzyme A binding pocket [chemical binding]; other site 484022001884 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 484022001885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 484022001886 dimer interface [polypeptide binding]; other site 484022001887 conserved gate region; other site 484022001888 putative PBP binding loops; other site 484022001889 ABC-ATPase subunit interface; other site 484022001890 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 484022001891 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484022001892 Walker A/P-loop; other site 484022001893 ATP binding site [chemical binding]; other site 484022001894 Q-loop/lid; other site 484022001895 ABC transporter signature motif; other site 484022001896 Walker B; other site 484022001897 D-loop; other site 484022001898 H-loop/switch region; other site 484022001899 YGGT family; Region: YGGT; cl00508 484022001900 YGGT family; Region: YGGT; cl00508 484022001901 A functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site...; Region: Peptidase_M14-like_4; cd06231 484022001902 putative active site [active] 484022001903 Zn-binding site [ion binding]; other site 484022001904 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 484022001905 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 484022001906 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 484022001907 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 484022001908 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 484022001909 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 484022001910 trimer interface [polypeptide binding]; other site 484022001911 putative metal binding site [ion binding]; other site 484022001912 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 484022001913 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 484022001914 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 484022001915 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 484022001916 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 484022001917 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 484022001918 classical (c) SDRs; Region: SDR_c; cd05233 484022001919 NAD(P) binding site [chemical binding]; other site 484022001920 active site 484022001921 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022001922 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 484022001923 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484022001924 Walker A/P-loop; other site 484022001925 ATP binding site [chemical binding]; other site 484022001926 Q-loop/lid; other site 484022001927 ABC transporter signature motif; other site 484022001928 Walker B; other site 484022001929 D-loop; other site 484022001930 H-loop/switch region; other site 484022001931 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl01965 484022001932 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 484022001933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 484022001934 dimer interface [polypeptide binding]; other site 484022001935 conserved gate region; other site 484022001936 putative PBP binding loops; other site 484022001937 ABC-ATPase subunit interface; other site 484022001938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 484022001939 Zinc-finger domain; Region: zf-CHCC; cl01821 484022001940 CrcB-like protein; Region: CRCB; cl09114 484022001941 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 484022001942 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 484022001943 domain interfaces; other site 484022001944 active site 484022001945 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 484022001946 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 484022001947 RNB domain; Region: RNB; pfam00773 484022001948 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 484022001949 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 484022001950 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 484022001951 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 484022001952 dimer interface [polypeptide binding]; other site 484022001953 anticodon binding site; other site 484022001954 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 484022001955 homodimer interface [polypeptide binding]; other site 484022001956 motif 1; other site 484022001957 active site 484022001958 motif 2; other site 484022001959 GAD domain; Region: GAD; pfam02938 484022001960 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 484022001961 motif 3; other site 484022001962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022001963 Coenzyme A binding pocket [chemical binding]; other site 484022001964 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484022001965 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 484022001966 putative active site [active] 484022001967 catalytic triad [active] 484022001968 putative dimer interface [polypeptide binding]; other site 484022001969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001970 putative substrate translocation pore; other site 484022001971 D-galactonate transporter; Region: 2A0114; TIGR00893 484022001972 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 484022001973 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 484022001974 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 484022001975 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 484022001976 tetramerization interface [polypeptide binding]; other site 484022001977 NAD(P) binding site [chemical binding]; other site 484022001978 catalytic residues [active] 484022001979 phosphate acetyltransferase; Reviewed; Region: PRK05632 484022001980 DRTGG domain; Region: DRTGG; cl12147 484022001981 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 484022001982 Acetokinase family; Region: Acetate_kinase; cl01029 484022001983 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 484022001984 dimer interface [polypeptide binding]; other site 484022001985 ssDNA binding site [nucleotide binding]; other site 484022001986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484022001987 RecX family; Region: RecX; cl00936 484022001988 recombinase A; Provisional; Region: recA; PRK09354 484022001989 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 484022001990 hexamer interface [polypeptide binding]; other site 484022001991 Walker A motif; other site 484022001992 ATP binding site [chemical binding]; other site 484022001993 Walker B motif; other site 484022001994 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 484022001995 SecA binding site; other site 484022001996 Preprotein binding site; other site 484022001997 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484022001998 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 484022001999 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 484022002000 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 484022002001 tandem repeat interface [polypeptide binding]; other site 484022002002 oligomer interface [polypeptide binding]; other site 484022002003 active site residues [active] 484022002004 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002005 Integrase core domain; Region: rve; cl01316 484022002006 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 484022002007 dimer interface [polypeptide binding]; other site 484022002008 [2Fe-2S] cluster binding site [ion binding]; other site 484022002009 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 484022002010 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 484022002011 dimer interface [polypeptide binding]; other site 484022002012 PYR/PP interface [polypeptide binding]; other site 484022002013 TPP binding site [chemical binding]; other site 484022002014 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022002015 TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize...; Region: TPP_PDC_IPDC; cd02005 484022002016 TPP-binding site [chemical binding]; other site 484022002017 dimer interface [polypeptide binding]; other site 484022002018 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 484022002019 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 484022002020 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 484022002021 catalytic motif [active] 484022002022 Zn binding site [ion binding]; other site 484022002023 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 484022002024 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 484022002025 Lumazine binding domain; Region: Lum_binding; pfam00677 484022002026 Lumazine binding domain; Region: Lum_binding; pfam00677 484022002027 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 484022002028 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 484022002029 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 484022002030 dimerization interface [polypeptide binding]; other site 484022002031 active site 484022002032 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 484022002033 homopentamer interface [polypeptide binding]; other site 484022002034 active site 484022002035 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 484022002036 active site 484022002037 catalytic residues [active] 484022002038 metal binding site [ion binding]; metal-binding site 484022002039 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 484022002040 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 484022002041 GTP-binding protein LepA; Provisional; Region: PRK05433 484022002042 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 484022002043 G1 box; other site 484022002044 putative GEF interaction site [polypeptide binding]; other site 484022002045 GTP/Mg2+ binding site [chemical binding]; other site 484022002046 Switch I region; other site 484022002047 G2 box; other site 484022002048 G3 box; other site 484022002049 Switch II region; other site 484022002050 G4 box; other site 484022002051 G5 box; other site 484022002052 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 484022002053 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 484022002054 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 484022002055 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 484022002056 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 484022002057 putative substrate binding pocket [chemical binding]; other site 484022002058 trimer interface [polypeptide binding]; other site 484022002059 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 484022002060 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 484022002061 dimer interface [polypeptide binding]; other site 484022002062 active site 484022002063 Protein of unknown function (DUF3111); Region: DUF3111; pfam11308 484022002064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002065 putative substrate translocation pore; other site 484022002066 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022002067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022002069 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484022002070 putative effector binding pocket; other site 484022002071 dimerization interface [polypeptide binding]; other site 484022002072 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 484022002073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022002074 catalytic residue [active] 484022002075 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 484022002076 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022002077 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 484022002078 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136 484022002079 putative FMN binding site [chemical binding]; other site 484022002080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002081 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 484022002082 Phosphate transporter family; Region: PHO4; cl00396 484022002083 Phosphoesterase family; Region: Phosphoesterase; cl10627 484022002084 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022002085 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 484022002086 putative metal dependent hydrolase; Provisional; Region: PRK11598 484022002087 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 484022002088 Sulfatase; Region: Sulfatase; cl10460 484022002089 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 484022002090 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 484022002091 LamB/YcsF family; Region: LamB_YcsF; cl00664 484022002092 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 484022002093 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 484022002094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002095 putative substrate translocation pore; other site 484022002096 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484022002097 Ligand Binding Site [chemical binding]; other site 484022002098 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484022002099 Ligand Binding Site [chemical binding]; other site 484022002100 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 484022002101 putative homodimer interface [polypeptide binding]; other site 484022002102 putative active site [active] 484022002103 catalytic site [active] 484022002104 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484022002105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022002106 ATP binding site [chemical binding]; other site 484022002107 putative Mg++ binding site [ion binding]; other site 484022002108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022002109 nucleotide binding region [chemical binding]; other site 484022002110 ATP-binding site [chemical binding]; other site 484022002111 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 484022002112 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 484022002113 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 484022002114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022002115 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 484022002116 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 484022002117 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022002118 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022002119 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022002120 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 484022002121 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484022002122 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484022002123 shikimate binding site; other site 484022002124 NAD(P) binding site [chemical binding]; other site 484022002125 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 484022002126 Ribonuclease P; Region: Ribonuclease_P; cl00457 484022002127 Domain of unknown function DUF37; Region: DUF37; cl00506 484022002128 membrane protein insertase; Provisional; Region: PRK01318 484022002129 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 484022002130 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484022002131 putative acyl-acceptor binding pocket; other site 484022002132 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484022002133 putative acyl-acceptor binding pocket; other site 484022002134 elongation factor P; Validated; Region: PRK00529 484022002135 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 484022002136 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 484022002137 RNA binding site [nucleotide binding]; other site 484022002138 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 484022002139 RNA binding site [nucleotide binding]; other site 484022002140 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 484022002141 putative active site [active] 484022002142 putative substrate binding site [chemical binding]; other site 484022002143 catalytic site [active] 484022002144 dimer interface [polypeptide binding]; other site 484022002145 pyruvate phosphate dikinase; Provisional; Region: PRK09279 484022002146 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 484022002147 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 484022002148 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 484022002149 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 484022002150 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 484022002151 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 484022002152 homodimer interface [polypeptide binding]; other site 484022002153 substrate-cofactor binding pocket; other site 484022002154 catalytic residue [active] 484022002155 2-isopropylmalate synthase; Validated; Region: PRK00915 484022002156 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 484022002157 active site 484022002158 catalytic residues [active] 484022002159 metal binding site [ion binding]; metal-binding site 484022002160 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 484022002161 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 484022002162 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 484022002163 substrate binding site [chemical binding]; other site 484022002164 ligand binding site [chemical binding]; other site 484022002165 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 484022002166 substrate binding site [chemical binding]; other site 484022002167 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 484022002168 isocitrate dehydrogenase; Validated; Region: PRK06451 484022002169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002170 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022002171 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 484022002172 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 484022002173 substrate binding [chemical binding]; other site 484022002174 active site 484022002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002176 putative substrate translocation pore; other site 484022002177 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 484022002178 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 484022002179 putative active site [active] 484022002180 dimerization interface [polypeptide binding]; other site 484022002181 putative tRNAtyr binding site [nucleotide binding]; other site 484022002182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022002183 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 484022002184 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 484022002185 phosphate binding site [ion binding]; other site 484022002186 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 484022002187 active site 484022002188 dimer interface [polypeptide binding]; other site 484022002189 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 484022002190 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 484022002191 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 484022002192 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 484022002193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 484022002194 Chorismate mutase type II; Region: CM_2; cl00693 484022002195 SOUL heme-binding protein; Region: SOUL; pfam04832 484022002196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022002198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022002199 dimerization interface [polypeptide binding]; other site 484022002200 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002201 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484022002202 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002203 Integrase core domain; Region: rve; cl01316 484022002204 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022002205 active site 484022002206 catalytic triad [active] 484022002207 oxyanion hole [active] 484022002208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022002209 ATP binding site [chemical binding]; other site 484022002210 Mg2+ binding site [ion binding]; other site 484022002211 G-X-G motif; other site 484022002212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 484022002213 Response regulator receiver domain; Region: Response_reg; pfam00072 484022002214 active site 484022002215 phosphorylation site [posttranslational modification] 484022002216 intermolecular recognition site; other site 484022002217 dimerization interface [polypeptide binding]; other site 484022002218 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002219 Integrase core domain; Region: rve; cl01316 484022002220 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which...; Region: B_lectin; cl00039 484022002221 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 484022002222 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 484022002223 dihydroorotase; Reviewed; Region: PRK09236 484022002224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 484022002225 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 484022002226 active site 484022002227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022002228 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 484022002229 Histidine phosphatase superfamily (branch 2); Region: His_Phos_2; pfam00328 484022002230 catalytic core [active] 484022002231 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 484022002232 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 484022002233 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 484022002234 catalytic site [active] 484022002235 subunit interface [polypeptide binding]; other site 484022002236 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 484022002237 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484022002238 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022002239 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 484022002240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484022002241 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022002242 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 484022002243 IMP binding site; other site 484022002244 dimer interface [polypeptide binding]; other site 484022002245 interdomain contacts; other site 484022002246 partial ornithine binding site; other site 484022002247 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 484022002248 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484022002249 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484022002250 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022002251 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022002252 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002253 Integrase core domain; Region: rve; cl01316 484022002254 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 484022002255 catalytic triad [active] 484022002256 Acylphosphatase; Region: Acylphosphatase; cl00551 484022002257 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 484022002258 HypF finger; Region: zf-HYPF; pfam07503 484022002259 HypF finger; Region: zf-HYPF; pfam07503 484022002260 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 484022002261 HupF/HypC family; Region: HupF_HypC; cl00394 484022002262 Hydrogenase formation hypA family; Region: HypD; cl12072 484022002263 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 484022002264 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 484022002265 dimerization interface [polypeptide binding]; other site 484022002266 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 484022002267 ATP binding site [chemical binding]; other site 484022002268 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 484022002269 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 484022002270 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 484022002271 FAD binding pocket [chemical binding]; other site 484022002272 FAD binding motif [chemical binding]; other site 484022002273 phosphate binding motif [ion binding]; other site 484022002274 beta-alpha-beta structure motif; other site 484022002275 NAD binding pocket [chemical binding]; other site 484022002276 Iron coordination center [ion binding]; other site 484022002277 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 484022002278 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 484022002279 High-affinity nickel-transport protein; Region: NicO; cl00964 484022002280 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 484022002281 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 484022002282 nickel binding site [ion binding]; other site 484022002283 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 484022002284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022002285 Walker A/P-loop; other site 484022002286 ATP binding site [chemical binding]; other site 484022002287 Q-loop/lid; other site 484022002288 ABC transporter signature motif; other site 484022002289 Walker B; other site 484022002290 D-loop; other site 484022002291 H-loop/switch region; other site 484022002292 ABC transporter; Region: ABC_tran_2; pfam12848 484022002293 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 484022002294 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022002295 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 484022002296 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484022002297 Fatty acid elongase 3-ketoacyl-CoA synthase 1; Region: FAE_3-kCoA_syn1; pfam07168 484022002298 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 484022002299 substrate binding site [chemical binding]; other site 484022002300 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 484022002301 dimer interface [polypeptide binding]; other site 484022002302 ATP binding site [chemical binding]; other site 484022002303 Protein of unknown function (DUF497); Region: DUF497; cl01108 484022002304 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 484022002305 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 484022002306 aminopeptidase N; Provisional; Region: pepN; PRK14015 484022002307 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 484022002308 active site 484022002309 Zn binding site [ion binding]; other site 484022002310 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 484022002311 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 484022002312 active site 484022002313 ribulose/triose binding site [chemical binding]; other site 484022002314 phosphate binding site [ion binding]; other site 484022002315 substrate (anthranilate) binding pocket [chemical binding]; other site 484022002316 product (indole) binding pocket [chemical binding]; other site 484022002317 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 484022002318 active site 484022002319 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 484022002320 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 484022002321 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 484022002322 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 484022002323 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 484022002324 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 484022002325 Glutamine amidotransferase class-I; Region: GATase; pfam00117 484022002326 glutamine binding [chemical binding]; other site 484022002327 catalytic triad [active] 484022002328 anthranilate synthase component I; Provisional; Region: PRK13564 484022002329 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 484022002330 chorismate binding enzyme; Region: Chorismate_bind; cl10555 484022002331 Trp repressor protein; Region: Trp_repressor; cl01121 484022002332 ribonuclease G; Provisional; Region: PRK11712 484022002333 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 484022002334 homodimer interface [polypeptide binding]; other site 484022002335 oligonucleotide binding site [chemical binding]; other site 484022002336 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 484022002337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022002338 Walker A motif; other site 484022002339 ATP binding site [chemical binding]; other site 484022002340 Walker B motif; other site 484022002341 arginine finger; other site 484022002342 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 484022002343 DnaA box-binding interface [nucleotide binding]; other site 484022002344 DNA polymerase III subunit beta; Validated; Region: PRK05643 484022002345 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 484022002346 putative DNA binding surface [nucleotide binding]; other site 484022002347 dimer interface [polypeptide binding]; other site 484022002348 beta-clamp/clamp loader binding surface; other site 484022002349 beta-clamp/translesion DNA polymerase binding surface; other site 484022002350 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022002351 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022002352 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022002353 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002354 Integrase core domain; Region: rve; cl01316 484022002355 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 484022002356 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 484022002357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002358 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022002359 putative substrate translocation pore; other site 484022002360 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 484022002361 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022002362 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 484022002363 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002364 Integrase core domain; Region: rve; cl01316 484022002365 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 484022002366 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 484022002367 hydrophobic ligand binding site; other site 484022002368 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002369 Integrase core domain; Region: rve; cl01316 484022002370 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 484022002371 iron-sulfur cluster [ion binding]; other site 484022002372 [2Fe-2S] cluster binding site [ion binding]; other site 484022002373 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 484022002374 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 484022002375 putative catalytic site [active] 484022002376 putative metal binding site [ion binding]; other site 484022002377 putative phosphate binding site [ion binding]; other site 484022002378 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484022002379 putative acyl-acceptor binding pocket; other site 484022002380 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484022002381 putative acyl-acceptor binding pocket; other site 484022002382 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 484022002383 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 484022002384 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 484022002385 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 484022002386 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 484022002387 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022002388 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 484022002389 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022002390 active site 484022002391 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 484022002392 Clp amino terminal domain; Region: Clp_N; pfam02861 484022002393 Clp amino terminal domain; Region: Clp_N; pfam02861 484022002394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022002395 Walker A motif; other site 484022002396 ATP binding site [chemical binding]; other site 484022002397 Walker B motif; other site 484022002398 arginine finger; other site 484022002399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022002400 Walker A motif; other site 484022002401 ATP binding site [chemical binding]; other site 484022002402 Walker B motif; other site 484022002403 arginine finger; other site 484022002404 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 484022002405 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 484022002406 tryptophan synthase; Region: PLN02591 484022002407 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 484022002408 substrate binding site [chemical binding]; other site 484022002409 active site 484022002410 catalytic residues [active] 484022002411 heterodimer interface [polypeptide binding]; other site 484022002412 tryptophan synthase, beta chain; Region: PLN02618 484022002413 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 484022002414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002415 catalytic residue [active] 484022002416 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 484022002417 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 484022002418 active site 484022002419 Zn binding site [ion binding]; other site 484022002420 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031 484022002421 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 484022002422 Cl- selectivity filter; other site 484022002423 Cl- binding residues [ion binding]; other site 484022002424 pore gating glutamate residue; other site 484022002425 dimer interface [polypeptide binding]; other site 484022002426 H+/Cl- coupling transport residue; other site 484022002427 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002428 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002429 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002430 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 484022002431 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484022002432 active site 484022002433 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 484022002434 aspartate kinase III; Validated; Region: PRK09084 484022002435 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 484022002436 nucleotide binding site [chemical binding]; other site 484022002437 substrate binding site [chemical binding]; other site 484022002438 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 484022002439 lysine allosteric regulatory site; other site 484022002440 dimer interface [polypeptide binding]; other site 484022002441 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 484022002442 dihydrodipicolinate reductase; Provisional; Region: PRK00048 484022002443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022002444 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 484022002445 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 484022002446 dihydrodipicolinate synthase; Region: dapA; TIGR00674 484022002447 dimer interface [polypeptide binding]; other site 484022002448 active site 484022002449 catalytic residue [active] 484022002450 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 484022002451 trimer interface [polypeptide binding]; other site 484022002452 active site 484022002453 substrate binding site [chemical binding]; other site 484022002454 CoA binding site [chemical binding]; other site 484022002455 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 484022002456 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 484022002457 dimer interface [polypeptide binding]; other site 484022002458 active site 484022002459 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022002460 catalytic residues [active] 484022002461 substrate binding site [chemical binding]; other site 484022002462 aspartate aminotransferase; Provisional; Region: PRK08361 484022002463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022002464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002465 homodimer interface [polypeptide binding]; other site 484022002466 catalytic residue [active] 484022002467 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 484022002468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002469 putative substrate translocation pore; other site 484022002470 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 484022002471 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 484022002472 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 484022002473 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 484022002474 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484022002475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022002476 K+-transporting ATPase, c chain; Region: KdpC; cl00944 484022002477 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 484022002478 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 484022002479 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 484022002480 Ligand Binding Site [chemical binding]; other site 484022002481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 484022002482 dimer interface [polypeptide binding]; other site 484022002483 phosphorylation site [posttranslational modification] 484022002484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022002485 ATP binding site [chemical binding]; other site 484022002486 Mg2+ binding site [ion binding]; other site 484022002487 G-X-G motif; other site 484022002488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484022002489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 484022002490 active site 484022002491 phosphorylation site [posttranslational modification] 484022002492 intermolecular recognition site; other site 484022002493 dimerization interface [polypeptide binding]; other site 484022002494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 484022002495 DNA binding site [nucleotide binding] 484022002496 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022002497 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022002498 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 484022002499 GTP1/OBG; Region: GTP1_OBG; pfam01018 484022002500 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 484022002501 G1 box; other site 484022002502 GTP/Mg2+ binding site [chemical binding]; other site 484022002503 Switch I region; other site 484022002504 G2 box; other site 484022002505 G3 box; other site 484022002506 Switch II region; other site 484022002507 G4 box; other site 484022002508 G5 box; other site 484022002509 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022002510 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 484022002511 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 484022002512 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 484022002513 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 484022002514 transmembrane helices; other site 484022002515 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022002516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002517 putative substrate translocation pore; other site 484022002518 putative protease; Provisional; Region: PRK15452 484022002519 Peptidase family U32; Region: Peptidase_U32; cl03113 484022002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022002521 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 484022002522 Outer membrane efflux protein; Region: OEP; pfam02321 484022002523 Outer membrane efflux protein; Region: OEP; pfam02321 484022002524 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 484022002525 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 484022002526 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 484022002527 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 484022002528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002529 catalytic residue [active] 484022002530 amidophosphoribosyltransferase; Provisional; Region: PRK09246 484022002531 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 484022002532 active site 484022002533 tetramer interface [polypeptide binding]; other site 484022002534 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 484022002535 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 484022002536 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 484022002537 dimerization interface [polypeptide binding]; other site 484022002538 ATP binding site [chemical binding]; other site 484022002539 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 484022002540 dimerization interface [polypeptide binding]; other site 484022002541 ATP binding site [chemical binding]; other site 484022002542 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 484022002543 putative active site [active] 484022002544 catalytic triad [active] 484022002545 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002546 Integrase core domain; Region: rve; cl01316 484022002547 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 484022002548 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 484022002549 active site 484022002550 catalytic residues [active] 484022002551 adenylosuccinate lyase; Provisional; Region: PRK07492 484022002552 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 484022002553 tetramer interface [polypeptide binding]; other site 484022002554 active site 484022002555 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 484022002556 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484022002557 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022002558 E3 interaction surface; other site 484022002559 lipoyl attachment site [posttranslational modification]; other site 484022002560 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 484022002561 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 484022002562 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 484022002563 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 484022002564 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 484022002565 GatB domain; Region: GatB_Yqey; cl11497 484022002566 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022002567 active site 484022002568 oxyanion hole [active] 484022002569 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 484022002570 catalytic triad [active] 484022002571 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022002572 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 484022002573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022002574 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 484022002575 IucA / IucC family; Region: IucA_IucC; pfam04183 484022002576 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 484022002577 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484022002578 Siderophore biosynthesis protein domain; Region: AlcB; pfam10331 484022002579 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 484022002580 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 484022002581 IucA / IucC family; Region: IucA_IucC; pfam04183 484022002582 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 484022002583 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484022002584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022002585 catalytic residue [active] 484022002586 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 484022002587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 484022002588 inhibitor-cofactor binding pocket; inhibition site 484022002589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002590 catalytic residue [active] 484022002591 aspartate kinase III; Validated; Region: PRK09084 484022002592 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 484022002593 putative catalytic residues [active] 484022002594 nucleotide binding site [chemical binding]; other site 484022002595 aspartate binding site [chemical binding]; other site 484022002596 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 484022002597 metal binding site 2 [ion binding]; metal-binding site 484022002598 putative DNA binding helix; other site 484022002599 metal binding site 1 [ion binding]; metal-binding site 484022002600 dimer interface [polypeptide binding]; other site 484022002601 structural Zn2+ binding site [ion binding]; other site 484022002602 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 484022002603 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 484022002604 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 484022002605 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 484022002606 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 484022002607 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 484022002608 putative dimer interface [polypeptide binding]; other site 484022002609 [2Fe-2S] cluster binding site [ion binding]; other site 484022002610 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 484022002611 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 484022002612 SLBB domain; Region: SLBB; pfam10531 484022002613 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 484022002614 NADH dehydrogenase subunit G; Validated; Region: PRK09129 484022002615 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484022002616 catalytic loop [active] 484022002617 iron binding site [ion binding]; other site 484022002618 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 484022002619 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 484022002620 molybdopterin cofactor binding site; other site 484022002621 NADH dehydrogenase; Region: NADHdh; cl00469 484022002622 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 484022002623 4Fe-4S binding domain; Region: Fer4; cl02805 484022002624 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 484022002625 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 484022002626 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 484022002627 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 484022002628 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 484022002629 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 484022002630 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 484022002631 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 484022002632 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 484022002633 Membrane fusogenic activity; Region: BMFP; cl01115 484022002634 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 484022002635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022002636 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 484022002637 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 484022002638 substrate binding site [chemical binding]; other site 484022002639 active site 484022002640 ribosome maturation protein RimP; Reviewed; Region: PRK00092 484022002641 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 484022002642 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 484022002643 Sm1 motif; other site 484022002644 D3 - B interaction site; other site 484022002645 D1 - D2 interaction site; other site 484022002646 Hfq - Hfq interaction site; other site 484022002647 RNA binding pocket [nucleotide binding]; other site 484022002648 Sm2 motif; other site 484022002649 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 484022002650 NusA N-terminal domain; Region: NusA_N; pfam08529 484022002651 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 484022002652 RNA binding site [nucleotide binding]; other site 484022002653 homodimer interface [polypeptide binding]; other site 484022002654 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 484022002655 G-X-X-G motif; other site 484022002656 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 484022002657 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 484022002658 translation initiation factor IF-2; Validated; Region: infB; PRK05306 484022002659 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484022002660 translation initiation factor IF-2; Region: IF-2; TIGR00487 484022002661 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484022002662 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 484022002663 G1 box; other site 484022002664 putative GEF interaction site [polypeptide binding]; other site 484022002665 GTP/Mg2+ binding site [chemical binding]; other site 484022002666 Switch I region; other site 484022002667 G2 box; other site 484022002668 G3 box; other site 484022002669 Switch II region; other site 484022002670 G4 box; other site 484022002671 G5 box; other site 484022002672 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 484022002673 Translation-initiation factor 2; Region: IF-2; pfam11987 484022002674 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 484022002675 Ribosome-binding factor A; Region: RBFA; cl00542 484022002676 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 484022002677 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 484022002678 dimer interface [polypeptide binding]; other site 484022002679 motif 1; other site 484022002680 active site 484022002681 motif 2; other site 484022002682 motif 3; other site 484022002683 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 484022002684 anticodon binding site; other site 484022002685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002686 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 484022002687 putative substrate translocation pore; other site 484022002688 Predicted ATPase [General function prediction only]; Region: COG1485 484022002689 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 484022002690 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 484022002691 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 484022002692 active site 484022002693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022002695 putative substrate translocation pore; other site 484022002696 ATP synthase A chain; Region: ATP-synt_A; cl00413 484022002697 ATP synthase subunit C; Region: ATP-synt_C; cl00466 484022002698 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 484022002699 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 484022002700 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 484022002701 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 484022002702 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 484022002703 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484022002704 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 484022002705 beta subunit interaction interface [polypeptide binding]; other site 484022002706 Walker A motif; other site 484022002707 ATP binding site [chemical binding]; other site 484022002708 Walker B motif; other site 484022002709 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484022002710 ATP synthase; Region: ATP-synt; cl00365 484022002711 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 484022002712 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484022002713 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 484022002714 alpha subunit interaction interface [polypeptide binding]; other site 484022002715 Walker A motif; other site 484022002716 ATP binding site [chemical binding]; other site 484022002717 Walker B motif; other site 484022002718 inhibitor binding site; inhibition site 484022002719 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484022002720 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 484022002721 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 484022002722 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022002723 active site 484022002724 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 484022002725 putative active site [active] 484022002726 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 484022002727 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 484022002728 putative GSH binding site [chemical binding]; other site 484022002729 catalytic residues [active] 484022002730 superoxide dismutase; Provisional; Region: PRK10543 484022002731 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 484022002732 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 484022002733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022002734 muropeptide transporter; Reviewed; Region: ampG; PRK11902 484022002735 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 484022002736 dimer interface [polypeptide binding]; other site 484022002737 Citrate synthase; Region: Citrate_synt; pfam00285 484022002738 active site 484022002739 citrylCoA binding site [chemical binding]; other site 484022002740 NADH binding [chemical binding]; other site 484022002741 cationic pore residues; other site 484022002742 oxalacetate/citrate binding site [chemical binding]; other site 484022002743 coenzyme A binding site [chemical binding]; other site 484022002744 catalytic triad [active] 484022002745 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 484022002746 Iron-sulfur protein interface; other site 484022002747 proximal quinone binding site [chemical binding]; other site 484022002748 SdhD (CybS) interface [polypeptide binding]; other site 484022002749 proximal heme binding site [chemical binding]; other site 484022002750 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 484022002751 SdhC subunit interface [polypeptide binding]; other site 484022002752 proximal heme binding site [chemical binding]; other site 484022002753 cardiolipin binding site; other site 484022002754 Iron-sulfur protein interface; other site 484022002755 proximal quinone binding site [chemical binding]; other site 484022002756 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 484022002757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022002758 domain; Region: Succ_DH_flav_C; pfam02910 484022002759 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 484022002760 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 484022002761 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 484022002762 TPP-binding site [chemical binding]; other site 484022002763 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 484022002764 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022002765 E3 interaction surface; other site 484022002766 lipoyl attachment site [posttranslational modification]; other site 484022002767 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 484022002768 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022002769 E3 interaction surface; other site 484022002770 lipoyl attachment site [posttranslational modification]; other site 484022002771 e3 binding domain; Region: E3_binding; pfam02817 484022002772 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 484022002773 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 484022002774 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 484022002775 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 484022002776 active site 484022002777 substrate binding site [chemical binding]; other site 484022002778 metal binding site [ion binding]; metal-binding site 484022002779 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 484022002780 substrate binding site [chemical binding]; other site 484022002781 dimer interface [polypeptide binding]; other site 484022002782 catalytic triad [active] 484022002783 Preprotein translocase SecG subunit; Region: SecG; cl09123 484022002784 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002785 Integrase core domain; Region: rve; cl01316 484022002786 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 484022002787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 484022002788 Integrase core domain; Region: rve; cl01316 484022002789 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002790 Terminase small subunit; Region: Terminase_2; cl01513 484022002791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002792 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002793 Integrase core domain; Region: rve; cl01316 484022002794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002795 Predicted membrane protein [Function unknown]; Region: COG3212 484022002796 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 484022002797 HemN family oxidoreductase; Provisional; Region: PRK05660 484022002798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 484022002799 FeS/SAM binding site; other site 484022002800 HemN C-terminal region; Region: HemN_C; pfam06969 484022002801 GtrA-like protein; Region: GtrA; cl00971 484022002802 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 484022002803 aconitate hydratase; Validated; Region: PRK09277 484022002804 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 484022002805 substrate binding site [chemical binding]; other site 484022002806 ligand binding site [chemical binding]; other site 484022002807 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 484022002808 substrate binding site [chemical binding]; other site 484022002809 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 484022002810 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 484022002811 Walker A motif; other site 484022002812 ATP binding site [chemical binding]; other site 484022002813 Walker B motif; other site 484022002814 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 484022002815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022002816 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 484022002817 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 484022002818 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 484022002819 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 484022002820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022002821 TIGR01777 family protein; Region: yfcH 484022002822 NAD(P) binding site [chemical binding]; other site 484022002823 active site 484022002824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 484022002825 dimer interface [polypeptide binding]; other site 484022002826 phosphorylation site [posttranslational modification] 484022002827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022002828 ATP binding site [chemical binding]; other site 484022002829 Mg2+ binding site [ion binding]; other site 484022002830 G-X-G motif; other site 484022002831 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022002832 Protein of unknown function (DUF523); Region: DUF523; cl00733 484022002833 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 484022002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002835 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 484022002836 putative substrate translocation pore; other site 484022002837 multidrug efflux protein; Reviewed; Region: PRK09579 484022002838 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484022002839 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 484022002840 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 484022002841 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 484022002842 active site 484022002843 NTP binding site [chemical binding]; other site 484022002844 metal binding triad [ion binding]; metal-binding site 484022002845 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 484022002846 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 484022002847 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 484022002848 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 484022002849 Walker A/P-loop; other site 484022002850 ATP binding site [chemical binding]; other site 484022002851 Q-loop/lid; other site 484022002852 ABC transporter signature motif; other site 484022002853 Walker B; other site 484022002854 D-loop; other site 484022002855 H-loop/switch region; other site 484022002856 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 484022002857 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 484022002858 DNA polymerase I; Provisional; Region: PRK05755 484022002859 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 484022002860 active site 484022002861 metal binding site 1 [ion binding]; metal-binding site 484022002862 putative 5' ssDNA interaction site; other site 484022002863 metal binding site 3; metal-binding site 484022002864 metal binding site 2 [ion binding]; metal-binding site 484022002865 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 484022002866 putative DNA binding site [nucleotide binding]; other site 484022002867 putative metal binding site [ion binding]; other site 484022002868 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 484022002869 active site 484022002870 catalytic site [active] 484022002871 substrate binding site [chemical binding]; other site 484022002872 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 484022002873 active site 484022002874 DNA binding site [nucleotide binding] 484022002875 catalytic site [active] 484022002876 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 484022002877 Sulfatase; Region: Sulfatase; cl10460 484022002878 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 484022002879 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 484022002880 intersubunit interface [polypeptide binding]; other site 484022002881 active site 484022002882 catalytic residue [active] 484022002883 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 484022002884 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 484022002885 Nucleoside recognition; Region: Gate; cl00486 484022002886 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 484022002887 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 484022002888 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 484022002889 Nucleoside recognition; Region: Gate; cl00486 484022002890 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 484022002891 thymidylate kinase; Validated; Region: tmk; PRK00698 484022002892 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 484022002893 TMP-binding site; other site 484022002894 ATP-binding site [chemical binding]; other site 484022002895 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 484022002896 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 484022002897 G1 box; other site 484022002898 putative GEF interaction site [polypeptide binding]; other site 484022002899 GTP/Mg2+ binding site [chemical binding]; other site 484022002900 Switch I region; other site 484022002901 G2 box; other site 484022002902 G3 box; other site 484022002903 Switch II region; other site 484022002904 G4 box; other site 484022002905 G5 box; other site 484022002906 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 484022002907 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 484022002908 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 484022002909 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 484022002910 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 484022002911 P loop; other site 484022002912 GTP binding site [chemical binding]; other site 484022002913 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 484022002914 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022002915 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 484022002916 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 484022002917 peptide binding site [polypeptide binding]; other site 484022002918 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 484022002919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 484022002920 dimer interface [polypeptide binding]; other site 484022002921 conserved gate region; other site 484022002922 putative PBP binding loops; other site 484022002923 ABC-ATPase subunit interface; other site 484022002924 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 484022002925 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484022002926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 484022002927 dimer interface [polypeptide binding]; other site 484022002928 conserved gate region; other site 484022002929 putative PBP binding loops; other site 484022002930 ABC-ATPase subunit interface; other site 484022002931 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 484022002932 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 484022002933 Walker A/P-loop; other site 484022002934 ATP binding site [chemical binding]; other site 484022002935 Q-loop/lid; other site 484022002936 ABC transporter signature motif; other site 484022002937 Walker B; other site 484022002938 D-loop; other site 484022002939 H-loop/switch region; other site 484022002940 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484022002941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022002943 putative substrate translocation pore; other site 484022002944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022002946 putative substrate translocation pore; other site 484022002947 glycerol kinase; Provisional; Region: glpK; PRK00047 484022002948 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 484022002949 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 484022002950 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 484022002951 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 484022002952 amphipathic channel; other site 484022002953 Asn-Pro-Ala signature motifs; other site 484022002954 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 484022002955 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022002956 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 484022002957 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022002958 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 484022002959 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022002960 elongation factor Tu; Reviewed; Region: PRK00049 484022002961 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 484022002962 G1 box; other site 484022002963 GEF interaction site [polypeptide binding]; other site 484022002964 GTP/Mg2+ binding site [chemical binding]; other site 484022002965 Switch I region; other site 484022002966 G2 box; other site 484022002967 G3 box; other site 484022002968 Switch II region; other site 484022002969 G4 box; other site 484022002970 G5 box; other site 484022002971 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 484022002972 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 484022002973 Antibiotic Binding Site [chemical binding]; other site 484022002974 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 484022002975 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 484022002976 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 484022002977 putative homodimer interface [polypeptide binding]; other site 484022002978 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 484022002979 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 484022002980 23S rRNA interface [nucleotide binding]; other site 484022002981 L7/L12 interface [polypeptide binding]; other site 484022002982 putative thiostrepton binding site; other site 484022002983 L25 interface [polypeptide binding]; other site 484022002984 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 484022002985 mRNA/rRNA interface [nucleotide binding]; other site 484022002986 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 484022002987 23S rRNA interface [nucleotide binding]; other site 484022002988 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 484022002989 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 484022002990 core dimer interface [polypeptide binding]; other site 484022002991 peripheral dimer interface [polypeptide binding]; other site 484022002992 L10 interface [polypeptide binding]; other site 484022002993 L11 interface [polypeptide binding]; other site 484022002994 putative EF-Tu interaction site [polypeptide binding]; other site 484022002995 putative EF-G interaction site [polypeptide binding]; other site 484022002996 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 484022002997 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 484022002998 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 484022002999 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 484022003000 RPB11 interaction site [polypeptide binding]; other site 484022003001 RPB12 interaction site [polypeptide binding]; other site 484022003002 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 484022003003 RPB3 interaction site [polypeptide binding]; other site 484022003004 RPB1 interaction site [polypeptide binding]; other site 484022003005 RPB11 interaction site [polypeptide binding]; other site 484022003006 RPB10 interaction site [polypeptide binding]; other site 484022003007 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 484022003008 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 484022003009 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 484022003010 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 484022003011 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 484022003012 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 484022003013 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 484022003014 cleft; other site 484022003015 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 484022003016 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 484022003017 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 484022003018 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 484022003019 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 484022003020 DNA binding site [nucleotide binding] 484022003021 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 484022003022 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 484022003023 UGMP family protein; Validated; Region: PRK09604 484022003024 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 484022003025 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003026 Di-iron ligands [ion binding]; other site 484022003027 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003028 S-adenosylmethionine synthetase; Validated; Region: PRK05250 484022003029 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 484022003030 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 484022003031 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 484022003032 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 484022003033 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 484022003034 RimM N-terminal domain; Region: RimM; pfam01782 484022003035 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 484022003036 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 484022003037 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 484022003038 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 484022003039 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 484022003040 Int/Topo IB signature motif; other site 484022003041 active site 484022003042 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 484022003043 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 484022003044 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 484022003045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022003046 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 484022003047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003048 NAD(P) binding site [chemical binding]; other site 484022003049 active site 484022003050 peptide synthase; Provisional; Region: PRK12467 484022003051 Phosphopantetheine attachment site; Region: PP-binding; cl09936 484022003052 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 484022003053 putative NAD(P) binding site [chemical binding]; other site 484022003054 active site 484022003055 putative substrate binding site [chemical binding]; other site 484022003056 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 484022003057 putative active site [active] 484022003058 Ap4A binding site [chemical binding]; other site 484022003059 nudix motif; other site 484022003060 putative metal binding site [ion binding]; other site 484022003061 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 484022003062 active site 484022003063 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 484022003064 amidase catalytic site [active] 484022003065 Zn binding residues [ion binding]; other site 484022003066 substrate binding site [chemical binding]; other site 484022003067 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 484022003068 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 484022003069 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 484022003070 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022003071 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 484022003072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 484022003073 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 484022003074 anchoring element; other site 484022003075 dimer interface [polypeptide binding]; other site 484022003076 ATP binding site [chemical binding]; other site 484022003077 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 484022003078 active site 484022003079 metal binding site [ion binding]; metal-binding site 484022003080 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484022003081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003082 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022003083 putative substrate translocation pore; other site 484022003084 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 484022003085 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 484022003086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 484022003087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 484022003088 TPR motif; other site 484022003089 binding surface 484022003090 glutamyl-tRNA reductase; Provisional; Region: PRK13940 484022003091 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 484022003092 tRNA; other site 484022003093 putative tRNA binding site [nucleotide binding]; other site 484022003094 putative NADP binding site [chemical binding]; other site 484022003095 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 484022003096 peptide chain release factor 1; Validated; Region: prfA; PRK00591 484022003097 RF-1 domain; Region: RF-1; cl02875 484022003098 RF-1 domain; Region: RF-1; cl02875 484022003099 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 484022003100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022003101 S-adenosylmethionine binding site [chemical binding]; other site 484022003102 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 484022003103 Protein of unknown function (DUF328); Region: DUF328; cl01143 484022003104 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 484022003105 Predicted exporter [General function prediction only]; Region: COG4258 484022003106 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 484022003107 active site 484022003108 Predicted acyltransferase [General function prediction only]; Region: COG4261 484022003109 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484022003110 putative acyl-acceptor binding pocket; other site 484022003111 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 484022003112 Ligand binding site [chemical binding]; other site 484022003113 Putative Catalytic site [active] 484022003114 DXD motif; other site 484022003115 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 484022003116 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 484022003117 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 484022003118 Predicted membrane protein [Function unknown]; Region: COG4648 484022003119 Phosphopantetheine attachment site; Region: PP-binding; cl09936 484022003120 Phosphopantetheine attachment site; Region: PP-binding; cl09936 484022003121 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484022003122 putative acyl-acceptor binding pocket; other site 484022003123 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484022003124 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 484022003125 dimer interface [polypeptide binding]; other site 484022003126 active site 484022003127 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 484022003128 putative active site 1 [active] 484022003129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003130 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 484022003131 NAD(P) binding site [chemical binding]; other site 484022003132 active site 484022003133 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 484022003134 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484022003135 dimer interface [polypeptide binding]; other site 484022003136 active site 484022003137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022003138 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 484022003139 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 484022003140 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 484022003141 G1 box; other site 484022003142 GTP/Mg2+ binding site [chemical binding]; other site 484022003143 Switch I region; other site 484022003144 G2 box; other site 484022003145 G3 box; other site 484022003146 Switch II region; other site 484022003147 G4 box; other site 484022003148 G5 box; other site 484022003149 Nucleoside recognition; Region: Gate; cl00486 484022003150 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 484022003151 Nucleoside recognition; Region: Gate; cl00486 484022003152 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 484022003153 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 484022003154 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 484022003155 oligomerisation interface [polypeptide binding]; other site 484022003156 mobile loop; other site 484022003157 roof hairpin; other site 484022003158 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 484022003159 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 484022003160 ring oligomerisation interface [polypeptide binding]; other site 484022003161 ATP/Mg binding site [chemical binding]; other site 484022003162 stacking interactions; other site 484022003163 hinge regions; other site 484022003164 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022003165 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022003166 short chain dehydrogenase; Provisional; Region: PRK05693 484022003167 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 484022003168 NADP binding site [chemical binding]; other site 484022003169 active site 484022003170 steroid binding site; other site 484022003171 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 484022003172 active site 484022003173 catalytic residues [active] 484022003174 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 484022003175 DNA-binding interface [nucleotide binding]; DNA binding site 484022003176 Predicted flavoproteins [General function prediction only]; Region: COG2081 484022003177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022003178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003179 putative substrate translocation pore; other site 484022003180 glutamate dehydrogenase; Provisional; Region: PRK09414 484022003181 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 484022003182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003183 NAD(P) binding pocket [chemical binding]; other site 484022003184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 484022003185 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 484022003186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 484022003187 active site 484022003188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022003189 substrate binding site [chemical binding]; other site 484022003190 catalytic residues [active] 484022003191 dimer interface [polypeptide binding]; other site 484022003192 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022003193 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 484022003194 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 484022003195 DNA binding site [nucleotide binding] 484022003196 active site 484022003197 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484022003198 mercuric reductase; Validated; Region: PRK06370 484022003199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022003200 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022003201 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 484022003202 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 484022003203 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 484022003204 HSP70 interaction site [polypeptide binding]; other site 484022003205 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 484022003206 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 484022003207 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003208 Integrase core domain; Region: rve; cl01316 484022003209 EamA-like transporter family; Region: EamA; cl01037 484022003210 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484022003211 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022003212 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 484022003213 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484022003214 synthetase active site [active] 484022003215 NTP binding site [chemical binding]; other site 484022003216 metal binding site [ion binding]; metal-binding site 484022003217 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 484022003218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022003219 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 484022003220 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484022003221 DNA binding site [nucleotide binding] 484022003222 Int/Topo IB signature motif; other site 484022003223 active site 484022003224 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022003225 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022003226 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 484022003227 SecA binding site; other site 484022003228 Preprotein binding site; other site 484022003229 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 484022003230 MutS domain I; Region: MutS_I; pfam01624 484022003231 MutS family domain IV; Region: MutS_IV; pfam05190 484022003232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022003233 Walker A/P-loop; other site 484022003234 ATP binding site [chemical binding]; other site 484022003235 Q-loop/lid; other site 484022003236 ABC transporter signature motif; other site 484022003237 Walker B; other site 484022003238 D-loop; other site 484022003239 H-loop/switch region; other site 484022003240 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 484022003241 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 484022003242 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 484022003243 putative active site [active] 484022003244 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 484022003245 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 484022003246 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 484022003247 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 484022003248 active site 484022003249 HIGH motif; other site 484022003250 dimer interface [polypeptide binding]; other site 484022003251 KMSKS motif; other site 484022003252 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022003253 active site 484022003254 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 484022003255 CoA-binding site [chemical binding]; other site 484022003256 ATP-binding [chemical binding]; other site 484022003257 Uncharacterized conserved protein [Function unknown]; Region: COG1565 484022003258 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 484022003259 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 484022003260 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 484022003261 active site 484022003262 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 484022003263 Acyl transferase domain; Region: Acyl_transf_1; cl08282 484022003264 PKS_DH; Region: PKS_DH; smart00826 484022003265 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 484022003266 Enoylreductase; Region: PKS_ER; smart00829 484022003267 NAD(P) binding site [chemical binding]; other site 484022003268 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 484022003269 NADP binding site [chemical binding]; other site 484022003270 active site 484022003271 Phosphopantetheine attachment site; Region: PP-binding; cl09936 484022003272 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 484022003273 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 484022003274 substrate-cofactor binding pocket; other site 484022003275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003276 catalytic residue [active] 484022003277 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 484022003278 hydrophobic ligand binding site; other site 484022003279 Cytochrome P450; Region: p450; cl12078 484022003280 Sulfatase; Region: Sulfatase; cl10460 484022003281 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 484022003282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003283 NAD(P) binding site [chemical binding]; other site 484022003284 active site 484022003285 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 484022003286 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 484022003287 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 484022003288 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 484022003289 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 484022003290 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 484022003291 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 484022003292 Vi polysaccharide export inner membrane protein VexD; Provisional; Region: PRK15178 484022003293 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 484022003294 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 484022003295 Walker A/P-loop; other site 484022003296 ATP binding site [chemical binding]; other site 484022003297 Q-loop/lid; other site 484022003298 ABC transporter signature motif; other site 484022003299 Walker B; other site 484022003300 D-loop; other site 484022003301 H-loop/switch region; other site 484022003302 ABC-2 type transporter; Region: ABC2_membrane; cl11417 484022003303 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 484022003304 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 484022003305 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 484022003306 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 484022003307 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 484022003308 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 484022003309 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 484022003310 NAD(P) binding site [chemical binding]; other site 484022003311 homodimer interface [polypeptide binding]; other site 484022003312 substrate binding site [chemical binding]; other site 484022003313 active site 484022003314 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 484022003315 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 484022003316 inhibitor-cofactor binding pocket; inhibition site 484022003317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003318 catalytic residue [active] 484022003319 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 484022003320 putative trimer interface [polypeptide binding]; other site 484022003321 putative CoA binding site [chemical binding]; other site 484022003322 NeuB family; Region: NeuB; cl00496 484022003323 NeuB family; Region: NeuB; cl00496 484022003324 SAF domain; Region: SAF; cl00555 484022003325 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 484022003326 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 484022003327 active site 484022003328 homodimer interface [polypeptide binding]; other site 484022003329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 484022003330 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 484022003331 Substrate binding site [chemical binding]; other site 484022003332 metal binding site [ion binding]; metal-binding site 484022003333 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 484022003334 ligand binding site [chemical binding]; other site 484022003335 tetramer interface [polypeptide binding]; other site 484022003336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003337 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484022003338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003339 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 484022003340 Transposase, Mutator family; Region: Transposase_mut; pfam00872 484022003341 Transposase domain (DUF772); Region: DUF772; cl12084 484022003342 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 484022003343 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 484022003344 putative ligand binding site [chemical binding]; other site 484022003345 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 484022003346 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 484022003347 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 484022003348 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 484022003349 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003350 Integrase core domain; Region: rve; cl01316 484022003351 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 484022003352 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 484022003353 dimer interface [polypeptide binding]; other site 484022003354 TPP-binding site [chemical binding]; other site 484022003355 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 484022003356 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022003357 E3 interaction surface; other site 484022003358 lipoyl attachment site [posttranslational modification]; other site 484022003359 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022003360 E3 interaction surface; other site 484022003361 lipoyl attachment site [posttranslational modification]; other site 484022003362 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022003363 E3 interaction surface; other site 484022003364 lipoyl attachment site [posttranslational modification]; other site 484022003365 e3 binding domain; Region: E3_binding; pfam02817 484022003366 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 484022003367 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 484022003368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022003369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022003370 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022003371 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 484022003372 Protein of unknown function (DUF461); Region: DUF461; cl01071 484022003373 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003374 Integrase core domain; Region: rve; cl01316 484022003375 Chitin binding domain; Region: Chitin_bind_3; cl03871 484022003376 DNA gyrase subunit A; Validated; Region: PRK05560 484022003377 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 484022003378 CAP-like domain; other site 484022003379 Active site [active] 484022003380 primary dimer interface [polypeptide binding]; other site 484022003381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003383 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003384 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003385 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003386 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003387 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 484022003388 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 484022003389 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 484022003390 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 484022003391 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 484022003392 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 484022003393 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 484022003394 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 484022003395 Surface antigen; Region: Bac_surface_Ag; cl03097 484022003396 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 484022003397 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 484022003398 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 484022003399 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 484022003400 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 484022003401 trimer interface [polypeptide binding]; other site 484022003402 active site 484022003403 UDP-GlcNAc binding site [chemical binding]; other site 484022003404 lipid binding site [chemical binding]; lipid-binding site 484022003405 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 484022003406 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 484022003407 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 484022003408 active site 484022003409 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 484022003410 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 484022003411 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022003412 Active site [active] 484022003413 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 484022003414 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 484022003415 substrate binding pocket [chemical binding]; other site 484022003416 chain length determination region; other site 484022003417 substrate-Mg2+ binding site; other site 484022003418 catalytic residues [active] 484022003419 aspartate-rich region 1; other site 484022003420 active site lid residues [active] 484022003421 aspartate-rich region 2; other site 484022003422 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 484022003423 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 484022003424 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 484022003425 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 484022003426 active site 484022003427 dimerization interface [polypeptide binding]; other site 484022003428 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 484022003429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 484022003431 active site 484022003432 phosphorylation site [posttranslational modification] 484022003433 intermolecular recognition site; other site 484022003434 dimerization interface [polypeptide binding]; other site 484022003435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 484022003436 DNA binding site [nucleotide binding] 484022003437 signal peptidase I; Provisional; Region: PRK10861 484022003438 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 484022003439 Catalytic site [active] 484022003440 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 484022003441 ribonuclease III; Reviewed; Region: rnc; PRK00102 484022003442 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 484022003443 dimerization interface [polypeptide binding]; other site 484022003444 active site 484022003445 metal binding site [ion binding]; metal-binding site 484022003446 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 484022003447 dsRNA binding site [nucleotide binding]; other site 484022003448 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 484022003449 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 484022003450 RNA binding site [nucleotide binding]; other site 484022003451 active site 484022003452 ribonuclease R; Region: RNase_R; TIGR02063 484022003453 RNB domain; Region: RNB; pfam00773 484022003454 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 484022003455 RNA binding site [nucleotide binding]; other site 484022003456 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003457 Fatty acid desaturase; Region: FA_desaturase; pfam00487 484022003458 Di-iron ligands [ion binding]; other site 484022003459 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003460 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 484022003461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003462 NAD(P) binding site [chemical binding]; other site 484022003463 active site 484022003464 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 484022003465 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 484022003466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022003467 S-adenosylmethionine binding site [chemical binding]; other site 484022003468 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 484022003469 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 484022003470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022003471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 484022003472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022003473 ATP binding site [chemical binding]; other site 484022003474 Mg2+ binding site [ion binding]; other site 484022003475 G-X-G motif; other site 484022003476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484022003477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 484022003478 active site 484022003479 phosphorylation site [posttranslational modification] 484022003480 intermolecular recognition site; other site 484022003481 dimerization interface [polypeptide binding]; other site 484022003482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 484022003483 DNA binding site [nucleotide binding] 484022003484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022003485 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 484022003486 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 484022003487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 484022003488 ornithine cyclodeaminase; Validated; Region: PRK07589 484022003489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003490 Arginase family; Region: Arginase; cl00306 484022003491 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 484022003492 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general...; Region: PBEF_like; cd01569 484022003493 active site 484022003494 Protein of unknown function (DUF465); Region: DUF465; cl01070 484022003495 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484022003496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003497 putative substrate translocation pore; other site 484022003498 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 484022003499 CoenzymeA binding site [chemical binding]; other site 484022003500 subunit interaction site [polypeptide binding]; other site 484022003501 PHB binding site; other site 484022003502 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 484022003503 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484022003504 dimer interface [polypeptide binding]; other site 484022003505 active site 484022003506 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 484022003507 acyl-CoA binding pocket [chemical binding]; other site 484022003508 CoA binding site [chemical binding]; other site 484022003509 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 484022003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003511 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484022003512 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 484022003513 substrate binding site [chemical binding]; other site 484022003514 oxyanion hole (OAH) forming residues; other site 484022003515 trimer interface [polypeptide binding]; other site 484022003516 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 484022003517 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 484022003518 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 484022003519 active site 484022003520 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 484022003521 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 484022003522 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 484022003523 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 484022003524 catalytic residues [active] 484022003525 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 484022003526 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 484022003527 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 484022003528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022003529 ATP binding site [chemical binding]; other site 484022003530 putative Mg++ binding site [ion binding]; other site 484022003531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 484022003532 Helicase associated domain (HA2); Region: HA2; cl04503 484022003533 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 484022003534 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 484022003535 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 484022003536 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 484022003537 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 484022003538 NAD(P) binding site [chemical binding]; other site 484022003539 homodimer interface [polypeptide binding]; other site 484022003540 substrate binding site [chemical binding]; other site 484022003541 active site 484022003542 Bacterial sugar transferase; Region: Bac_transf; cl00939 484022003543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003544 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 484022003545 NAD(P) binding site [chemical binding]; other site 484022003546 active site 484022003547 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 484022003548 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 484022003549 Substrate binding site [chemical binding]; other site 484022003550 Cupin domain; Region: Cupin_2; cl09118 484022003551 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 484022003552 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 484022003553 NADP-binding site; other site 484022003554 homotetramer interface [polypeptide binding]; other site 484022003555 substrate binding site [chemical binding]; other site 484022003556 homodimer interface [polypeptide binding]; other site 484022003557 active site 484022003558 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 484022003559 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 484022003560 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 484022003561 NADP binding site [chemical binding]; other site 484022003562 active site 484022003563 putative substrate binding site [chemical binding]; other site 484022003564 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 484022003565 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 484022003566 substrate binding site [chemical binding]; other site 484022003567 tetramer interface [polypeptide binding]; other site 484022003568 Cupin domain; Region: Cupin_2; cl09118 484022003569 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 484022003570 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 484022003571 NADP binding site [chemical binding]; other site 484022003572 active site 484022003573 putative substrate binding site [chemical binding]; other site 484022003574 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 484022003575 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 484022003576 NAD binding site [chemical binding]; other site 484022003577 substrate binding site [chemical binding]; other site 484022003578 homodimer interface [polypeptide binding]; other site 484022003579 active site 484022003580 ABC-2 type transporter; Region: ABC2_membrane; cl11417 484022003581 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 484022003582 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 484022003583 Walker A/P-loop; other site 484022003584 ATP binding site [chemical binding]; other site 484022003585 Q-loop/lid; other site 484022003586 ABC transporter signature motif; other site 484022003587 Walker B; other site 484022003588 D-loop; other site 484022003589 H-loop/switch region; other site 484022003590 Cupin domain; Region: Cupin_2; cl09118 484022003591 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 484022003592 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 484022003593 putative trimer interface [polypeptide binding]; other site 484022003594 putative CoA binding site [chemical binding]; other site 484022003595 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 484022003596 active site 484022003597 FemAB family; Region: FemAB; cl11444 484022003598 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 484022003599 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 484022003600 inhibitor-cofactor binding pocket; inhibition site 484022003601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003602 catalytic residue [active] 484022003603 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484022003604 active site 484022003605 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022003606 Rhamnan synthesis protein F; Region: RgpF; cl01529 484022003607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003608 NAD(P) binding site [chemical binding]; other site 484022003609 active site 484022003610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484022003611 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484022003612 active site 484022003613 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484022003614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484022003615 active site 484022003616 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 484022003617 metal binding site [ion binding]; metal-binding site 484022003618 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484022003619 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022003620 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484022003621 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 484022003622 metal binding site [ion binding]; metal-binding site 484022003623 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 484022003624 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 484022003625 active site 484022003626 substrate binding site [chemical binding]; other site 484022003627 metal binding site [ion binding]; metal-binding site 484022003628 transcription termination factor Rho; Provisional; Region: rho; PRK09376 484022003629 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 484022003630 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 484022003631 RNA binding site [nucleotide binding]; other site 484022003632 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 484022003633 multimer interface [polypeptide binding]; other site 484022003634 Walker A motif; other site 484022003635 ATP binding site [chemical binding]; other site 484022003636 Walker B motif; other site 484022003637 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484022003638 catalytic residues [active] 484022003639 exopolyphosphatase; Region: exo_poly_only; TIGR03706 484022003640 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 484022003641 recombination factor protein RarA; Reviewed; Region: PRK13342 484022003642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022003643 Walker A motif; other site 484022003644 ATP binding site [chemical binding]; other site 484022003645 Walker B motif; other site 484022003646 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 484022003647 arginine finger; other site 484022003648 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 484022003649 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 484022003650 dimer interface [polypeptide binding]; other site 484022003651 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 484022003652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003653 putative substrate translocation pore; other site 484022003654 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484022003655 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 484022003656 active site 484022003657 Cupin domain; Region: Cupin_2; cl09118 484022003658 Protein of unknown function (DUF523); Region: DUF523; cl00733 484022003659 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 484022003660 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484022003661 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484022003662 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 484022003663 Walker A/P-loop; other site 484022003664 ATP binding site [chemical binding]; other site 484022003665 Q-loop/lid; other site 484022003666 ABC transporter signature motif; other site 484022003667 Walker B; other site 484022003668 D-loop; other site 484022003669 H-loop/switch region; other site 484022003670 ABC-2 type transporter; Region: ABC2_membrane; cl11417 484022003671 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 484022003672 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 484022003673 Ligand binding site [chemical binding]; other site 484022003674 Putative Catalytic site [active] 484022003675 DXD motif; other site 484022003676 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 484022003677 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 484022003678 LysE type translocator; Region: LysE; cl00565 484022003679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022003680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022003681 Coenzyme A binding pocket [chemical binding]; other site 484022003682 guanine deaminase; Provisional; Region: PRK09228 484022003683 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 484022003684 active site 484022003685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003686 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022003687 putative substrate translocation pore; other site 484022003688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022003689 dimerization interface [polypeptide binding]; other site 484022003690 putative DNA binding site [nucleotide binding]; other site 484022003691 putative Zn2+ binding site [ion binding]; other site 484022003692 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 484022003693 active site residue [active] 484022003694 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 484022003695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022003696 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022003697 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 484022003698 active site residue [active] 484022003699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484022003700 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484022003701 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 484022003702 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 484022003703 Flagellin N-methylase; Region: FliB; cl00497 484022003704 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 484022003705 putative RNA binding site [nucleotide binding]; other site 484022003706 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484022003707 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 484022003708 putative active site [active] 484022003709 catalytic triad [active] 484022003710 multimer interface [polypeptide binding]; other site 484022003711 dimer interface [polypeptide binding]; other site 484022003712 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022003713 methionine aminotransferase; Validated; Region: PRK09082 484022003714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022003715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003716 homodimer interface [polypeptide binding]; other site 484022003717 catalytic residue [active] 484022003718 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003719 Integrase core domain; Region: rve; cl01316 484022003720 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484022003721 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484022003722 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484022003723 prolyl-tRNA synthetase; Provisional; Region: PRK09194 484022003724 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 484022003725 dimer interface [polypeptide binding]; other site 484022003726 motif 1; other site 484022003727 active site 484022003728 motif 2; other site 484022003729 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 484022003730 putative deacylase active site [active] 484022003731 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484022003732 active site 484022003733 motif 3; other site 484022003734 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 484022003735 anticodon binding site; other site 484022003736 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 484022003737 Fe-S metabolism associated domain; Region: SufE; cl00951 484022003738 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 484022003739 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 484022003740 active site 484022003741 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 484022003742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484022003743 Sporulation related domain; Region: SPOR; cl10051 484022003744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022003745 S-adenosylmethionine binding site [chemical binding]; other site 484022003746 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 484022003747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484022003748 non-specific DNA binding site [nucleotide binding]; other site 484022003749 salt bridge; other site 484022003750 sequence-specific DNA binding site [nucleotide binding]; other site 484022003751 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 484022003752 Catalytic site [active] 484022003753 EamA-like transporter family; Region: EamA; cl01037 484022003754 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 484022003755 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 484022003756 active site 484022003757 FMN binding site [chemical binding]; other site 484022003758 substrate binding site [chemical binding]; other site 484022003759 3Fe-4S cluster binding site [ion binding]; other site 484022003760 Cupin superfamily protein; Region: Cupin_4; pfam08007 484022003761 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 484022003762 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 484022003763 Predicted membrane protein [Function unknown]; Region: COG4129 484022003764 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 484022003765 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 484022003766 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 484022003767 active site 484022003768 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 484022003769 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 484022003770 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484022003771 PYR/PP interface [polypeptide binding]; other site 484022003772 dimer interface [polypeptide binding]; other site 484022003773 TPP binding site [chemical binding]; other site 484022003774 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022003775 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 484022003776 TPP-binding site; other site 484022003777 dimer interface [polypeptide binding]; other site 484022003778 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 484022003779 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022003780 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022003781 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 484022003782 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022003783 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022003784 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 484022003785 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 484022003786 tetramerization interface [polypeptide binding]; other site 484022003787 active site 484022003788 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022003789 pantoate--beta-alanine ligase; Region: panC; TIGR00018 484022003790 active site 484022003791 nucleotide binding site [chemical binding]; other site 484022003792 HIGH motif; other site 484022003793 KMSKS motif; other site 484022003794 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 484022003795 active site 484022003796 oligomerization interface [polypeptide binding]; other site 484022003797 metal binding site [ion binding]; metal-binding site 484022003798 Uncharacterized conserved protein [Function unknown]; Region: COG5495 484022003799 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 484022003800 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 484022003801 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 484022003802 nucleotide binding pocket [chemical binding]; other site 484022003803 K-X-D-G motif; other site 484022003804 catalytic site [active] 484022003805 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 484022003806 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 484022003807 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 484022003808 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 484022003809 Dimer interface [polypeptide binding]; other site 484022003810 BRCT sequence motif; other site 484022003811 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 484022003812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 484022003813 16S rRNA methyltransferase B; Provisional; Region: PRK10901 484022003814 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 484022003815 putative RNA binding site [nucleotide binding]; other site 484022003816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022003817 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 484022003818 active site 484022003819 dimerization interface [polypeptide binding]; other site 484022003820 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 484022003821 putative transporter; Provisional; Region: PRK03699 484022003822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022003823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022003824 YCII-related domain; Region: YCII; cl00999 484022003825 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 484022003826 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484022003827 dimer interface [polypeptide binding]; other site 484022003828 active site 484022003829 Phosphopantetheine attachment site; Region: PP-binding; cl09936 484022003830 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 484022003831 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 484022003832 NAD(P) binding site [chemical binding]; other site 484022003833 homotetramer interface [polypeptide binding]; other site 484022003834 homodimer interface [polypeptide binding]; other site 484022003835 active site 484022003836 Acyl transferase domain; Region: Acyl_transf_1; cl08282 484022003837 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 484022003838 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 484022003839 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 484022003840 dimer interface [polypeptide binding]; other site 484022003841 active site 484022003842 CoA binding pocket [chemical binding]; other site 484022003843 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 484022003844 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 484022003845 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 484022003846 transketolase; Reviewed; Region: PRK05899 484022003847 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484022003848 TPP-binding site [chemical binding]; other site 484022003849 dimer interface [polypeptide binding]; other site 484022003850 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484022003851 PYR/PP interface [polypeptide binding]; other site 484022003852 dimer interface [polypeptide binding]; other site 484022003853 TPP binding site [chemical binding]; other site 484022003854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484022003855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003856 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 484022003857 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 484022003858 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 484022003859 substrate binding site [chemical binding]; other site 484022003860 hinge regions; other site 484022003861 ADP binding site [chemical binding]; other site 484022003862 catalytic site [active] 484022003863 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 484022003864 pyruvate kinase; Provisional; Region: PRK05826 484022003865 domain interfaces; other site 484022003866 active site 484022003867 hypothetical protein; Provisional; Region: PRK08185 484022003868 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 484022003869 intersubunit interface [polypeptide binding]; other site 484022003870 active site 484022003871 zinc binding site [ion binding]; other site 484022003872 Na+ binding site [ion binding]; other site 484022003873 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 484022003874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003875 putative substrate translocation pore; other site 484022003876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022003877 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 484022003878 Protein of unknown function (DUF770); Region: DUF770; cl01402 484022003879 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 484022003880 Protein of unknown function (DUF877); Region: DUF877; pfam05943 484022003881 Intracellular growth locus C protein; Region: IglC; pfam11550 484022003882 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 484022003883 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 484022003884 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 484022003885 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 484022003886 dimer interface [polypeptide binding]; other site 484022003887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003888 catalytic residue [active] 484022003889 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 484022003890 active site 484022003891 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 484022003892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022003893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022003894 dimerization interface [polypeptide binding]; other site 484022003895 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 484022003896 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 484022003897 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 484022003898 G1 box; other site 484022003899 GTP/Mg2+ binding site [chemical binding]; other site 484022003900 Switch I region; other site 484022003901 G2 box; other site 484022003902 Switch II region; other site 484022003903 G3 box; other site 484022003904 G4 box; other site 484022003905 G5 box; other site 484022003906 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 484022003907 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 484022003908 30S subunit binding site; other site 484022003909 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484022003910 active site 484022003911 phosphorylation site [posttranslational modification] 484022003912 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 484022003913 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 484022003914 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 484022003915 RNA/DNA hybrid binding site [nucleotide binding]; other site 484022003916 active site 484022003917 Sodium:solute symporter family; Region: SSF; cl00456 484022003918 Predicted membrane protein [Function unknown]; Region: COG1289 484022003919 PAS fold; Region: PAS_4; pfam08448 484022003920 Transcriptional regulators [Transcription]; Region: MarR; COG1846 484022003921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022003922 Integrase core domain; Region: rve; cl01316 484022003923 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003924 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 484022003925 active site 484022003926 Stringent starvation protein B; Region: SspB; cl01120 484022003927 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022003928 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 484022003929 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 484022003930 23S rRNA interface [nucleotide binding]; other site 484022003931 L3 interface [polypeptide binding]; other site 484022003932 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 484022003933 MltA specific insert domain; Region: MltA; pfam03562 484022003934 3D domain; Region: 3D; cl01439 484022003935 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 484022003936 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 484022003937 dimer interface [polypeptide binding]; other site 484022003938 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 484022003939 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 484022003940 chaperone protein DnaJ; Provisional; Region: PRK10767 484022003941 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 484022003942 HSP70 interaction site [polypeptide binding]; other site 484022003943 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 484022003944 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 484022003945 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 484022003946 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 484022003947 homodimer interface [polypeptide binding]; other site 484022003948 NAD binding pocket [chemical binding]; other site 484022003949 ATP binding pocket [chemical binding]; other site 484022003950 Mg binding site [ion binding]; other site 484022003951 active-site loop [active] 484022003952 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 484022003953 Outer membrane efflux protein; Region: OEP; pfam02321 484022003954 Outer membrane efflux protein; Region: OEP; pfam02321 484022003955 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484022003956 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484022003957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003958 putative substrate translocation pore; other site 484022003959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003960 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484022003961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484022003962 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 484022003963 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 484022003964 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 484022003965 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022003966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003967 putative substrate translocation pore; other site 484022003968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022003969 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 484022003970 Protein of unknown function (DUF445); Region: DUF445; pfam04286 484022003971 mce related protein; Region: MCE; cl03606 484022003972 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 484022003973 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 484022003974 Walker A/P-loop; other site 484022003975 ATP binding site [chemical binding]; other site 484022003976 Q-loop/lid; other site 484022003977 ABC transporter signature motif; other site 484022003978 Walker B; other site 484022003979 D-loop; other site 484022003980 H-loop/switch region; other site 484022003981 Domain of unknown function DUF140; Region: DUF140; cl00510 484022003982 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 484022003983 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 484022003984 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 484022003985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022003986 RNA binding surface [nucleotide binding]; other site 484022003987 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 484022003988 active site 484022003989 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 484022003990 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022003991 FAD binding domain; Region: FAD_binding_4; pfam01565 484022003992 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 484022003993 dimer interface [polypeptide binding]; other site 484022003994 glycine-pyridoxal phosphate binding site [chemical binding]; other site 484022003995 active site 484022003996 folate binding site [chemical binding]; other site 484022003997 Protein of unknown function (DUF615); Region: DUF615; cl01147 484022003998 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 484022003999 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 484022004000 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484022004001 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 484022004002 Ligand Binding Site [chemical binding]; other site 484022004003 B3/4 domain; Region: B3_4; cl11458 484022004004 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 484022004005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022004006 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 484022004007 L-serine binding site [chemical binding]; other site 484022004008 ACT domain interface; other site 484022004009 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 484022004010 dimerization interface [polypeptide binding]; other site 484022004011 active site 484022004012 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 484022004013 ribonuclease E; Reviewed; Region: rne; PRK10811 484022004014 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 484022004015 homodimer interface [polypeptide binding]; other site 484022004016 oligonucleotide binding site [chemical binding]; other site 484022004017 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 484022004018 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484022004019 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022004020 catalytic residue [active] 484022004021 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 484022004022 Recombination protein O N terminal; Region: RecO_N; pfam11967 484022004023 Recombination protein O C terminal; Region: RecO_C; pfam02565 484022004024 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484022004025 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484022004026 BolA-like protein; Region: BolA; cl00386 484022004027 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 484022004028 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 484022004029 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 484022004030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022004031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022004032 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 484022004033 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role...; Region: PAP2_acid_phosphatase; cd03397 484022004034 active site 484022004035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 484022004036 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484022004037 ATP binding site [chemical binding]; other site 484022004038 putative Mg++ binding site [ion binding]; other site 484022004039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022004040 nucleotide binding region [chemical binding]; other site 484022004041 ATP-binding site [chemical binding]; other site 484022004042 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 484022004043 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 484022004044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 484022004045 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 484022004046 active site 484022004047 motif I; other site 484022004048 motif II; other site 484022004049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022004050 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 484022004051 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 484022004052 dimer interface [polypeptide binding]; other site 484022004053 active site 484022004054 metal binding site [ion binding]; metal-binding site 484022004055 glutathione binding site [chemical binding]; other site 484022004056 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 484022004057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022004058 S-adenosylmethionine binding site [chemical binding]; other site 484022004059 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 484022004060 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 484022004061 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 484022004062 NAD binding site [chemical binding]; other site 484022004063 homotetramer interface [polypeptide binding]; other site 484022004064 homodimer interface [polypeptide binding]; other site 484022004065 substrate binding site [chemical binding]; other site 484022004066 active site 484022004067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484022004068 hypothetical protein; Provisional; Region: PRK05409 484022004069 Protein of unknown function (DUF692); Region: DUF692; cl01263 484022004070 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 484022004071 DoxX; Region: DoxX; cl00976 484022004072 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 484022004073 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 484022004074 putative active site [active] 484022004075 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 484022004076 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 484022004077 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 484022004078 substrate binding site [chemical binding]; other site 484022004079 hexamer interface [polypeptide binding]; other site 484022004080 metal binding site [ion binding]; metal-binding site 484022004081 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 484022004082 Bacterial sugar transferase; Region: Bac_transf; cl00939 484022004083 UDP-glucose 4-epimerase; Region: PLN02240 484022004084 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 484022004085 NAD binding site [chemical binding]; other site 484022004086 homodimer interface [polypeptide binding]; other site 484022004087 active site 484022004088 substrate binding site [chemical binding]; other site 484022004089 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 484022004090 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 484022004091 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022004092 Walker A/P-loop; other site 484022004093 ATP binding site [chemical binding]; other site 484022004094 Q-loop/lid; other site 484022004095 ABC transporter signature motif; other site 484022004096 Walker B; other site 484022004097 D-loop; other site 484022004098 H-loop/switch region; other site 484022004099 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 484022004100 dimer interface [polypeptide binding]; other site 484022004101 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 484022004102 active site 484022004103 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 484022004104 Ligand Binding Site [chemical binding]; other site 484022004105 Molecular Tunnel; other site 484022004106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022004107 active site 484022004108 nucleotide binding site [chemical binding]; other site 484022004109 HIGH motif; other site 484022004110 KMSKS motif; other site 484022004111 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 484022004112 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 484022004113 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484022004114 active site 484022004115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022004116 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 484022004117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484022004118 active site 484022004119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022004120 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 484022004121 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 484022004122 metal binding site [ion binding]; metal-binding site 484022004123 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 484022004124 putative ADP-binding pocket [chemical binding]; other site 484022004125 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 484022004126 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484022004127 active site 484022004128 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 484022004129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022004130 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 484022004131 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 484022004132 substrate binding site [chemical binding]; other site 484022004133 ATP binding site [chemical binding]; other site 484022004134 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 484022004135 proposed catalytic triad [active] 484022004136 active site nucleophile [active] 484022004137 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 484022004138 catalytic nucleophile [active] 484022004139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004140 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022004141 putative substrate translocation pore; other site 484022004142 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 484022004143 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 484022004144 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 484022004145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 484022004146 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484022004147 synthetase active site [active] 484022004148 NTP binding site [chemical binding]; other site 484022004149 metal binding site [ion binding]; metal-binding site 484022004150 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 484022004151 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 484022004152 MULE transposase domain; Region: MULE; pfam10551 484022004153 Transposase, Mutator family; Region: Transposase_mut; pfam00872 484022004154 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 484022004155 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 484022004156 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 484022004157 putative active site [active] 484022004158 catalytic site [active] 484022004159 putative metal binding site [ion binding]; other site 484022004160 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 484022004161 putative MPT binding site; other site 484022004162 cyanophycin synthetase; Provisional; Region: PRK14016 484022004163 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022004164 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022004165 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022004166 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022004167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022004168 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 484022004169 homotrimer interaction site [polypeptide binding]; other site 484022004170 zinc binding site [ion binding]; other site 484022004171 CDP-binding sites; other site 484022004172 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484022004173 active site residue [active] 484022004174 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484022004175 active site residue [active] 484022004176 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022004177 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004178 Integrase core domain; Region: rve; cl01316 484022004179 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022004180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 484022004181 dimer interface [polypeptide binding]; other site 484022004182 conserved gate region; other site 484022004183 ABC-ATPase subunit interface; other site 484022004184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022004185 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 484022004186 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 484022004187 Walker A/P-loop; other site 484022004188 ATP binding site [chemical binding]; other site 484022004189 Q-loop/lid; other site 484022004190 ABC transporter signature motif; other site 484022004191 Walker B; other site 484022004192 D-loop; other site 484022004193 H-loop/switch region; other site 484022004194 NIL domain; Region: NIL; pfam09383 484022004195 Domain of unknown function (DUF205); Region: DUF205; cl00410 484022004196 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 484022004197 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 484022004198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022004199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022004200 dimerization interface [polypeptide binding]; other site 484022004201 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004202 Integrase core domain; Region: rve; cl01316 484022004203 Isochorismatase family; Region: Isochorismatase; pfam00857 484022004204 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 484022004205 catalytic triad [active] 484022004206 conserved cis-peptide bond; other site 484022004207 putative transporter; Provisional; Region: PRK03699 484022004208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004209 putative substrate translocation pore; other site 484022004210 Preprotein translocase subunit; Region: YajC; cl00806 484022004211 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 484022004212 Protein export membrane protein; Region: SecD_SecF; cl14618 484022004213 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 484022004214 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 484022004215 Protein export membrane protein; Region: SecD_SecF; cl14618 484022004216 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 484022004217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484022004218 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 484022004219 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 484022004220 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 484022004221 hinge; other site 484022004222 active site 484022004223 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 484022004224 RNA/DNA hybrid binding site [nucleotide binding]; other site 484022004225 active site 484022004226 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 484022004227 active site/substrate binding site [active] 484022004228 tetramer interface [polypeptide binding]; other site 484022004229 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 484022004230 active site clefts [active] 484022004231 zinc binding site [ion binding]; other site 484022004232 dimer interface [polypeptide binding]; other site 484022004233 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 484022004234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022004235 ATP binding site [chemical binding]; other site 484022004236 putative Mg++ binding site [ion binding]; other site 484022004237 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 484022004238 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004239 Integrase core domain; Region: rve; cl01316 484022004240 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484022004241 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 484022004242 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484022004243 Transposase IS200 like; Region: Y1_Tnp; cl00848 484022004244 HsdM N-terminal domain; Region: HsdM_N; pfam12161 484022004245 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004246 Integrase core domain; Region: rve; cl01316 484022004247 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 484022004248 trigger factor; Provisional; Region: tig; PRK01490 484022004249 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 484022004250 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 484022004251 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 484022004252 oligomer interface [polypeptide binding]; other site 484022004253 active site residues [active] 484022004254 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 484022004255 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 484022004256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022004257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022004258 Walker A motif; other site 484022004259 ATP binding site [chemical binding]; other site 484022004260 Walker B motif; other site 484022004261 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 484022004262 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 484022004263 Found in ATP-dependent protease La (LON); Region: LON; cl01056 484022004264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022004265 Walker A motif; other site 484022004266 ATP binding site [chemical binding]; other site 484022004267 Walker B motif; other site 484022004268 arginine finger; other site 484022004269 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 484022004270 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 484022004271 IHF dimer interface [polypeptide binding]; other site 484022004272 IHF - DNA interface [nucleotide binding]; other site 484022004273 periplasmic folding chaperone; Provisional; Region: PRK10788 484022004274 IPP transferase; Region: IPPT; cl00403 484022004275 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 484022004276 Sm1 motif; other site 484022004277 intra - hexamer interaction site; other site 484022004278 inter - hexamer interaction site [polypeptide binding]; other site 484022004279 nucleotide binding pocket [chemical binding]; other site 484022004280 Sm2 motif; other site 484022004281 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 484022004282 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 484022004283 G1 box; other site 484022004284 GTP/Mg2+ binding site [chemical binding]; other site 484022004285 Switch I region; other site 484022004286 G2 box; other site 484022004287 G3 box; other site 484022004288 Switch II region; other site 484022004289 G4 box; other site 484022004290 G5 box; other site 484022004291 hypothetical protein; Provisional; Region: PRK07588 484022004292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022004293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022004294 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 484022004295 HflK protein; Region: hflK; TIGR01933 484022004296 FtsH protease regulator HflC; Provisional; Region: PRK11029 484022004297 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 484022004298 Low molecular weight phosphatase family; Region: LMWPc; cd00115 484022004299 Active site [active] 484022004300 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 484022004301 G1 box; other site 484022004302 GTP/Mg2+ binding site [chemical binding]; other site 484022004303 Switch I region; other site 484022004304 G2 box; other site 484022004305 G3 box; other site 484022004306 Switch II region; other site 484022004307 G4 box; other site 484022004308 G5 box; other site 484022004309 threonine synthase; Reviewed; Region: PRK06721 484022004310 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 484022004311 homodimer interface [polypeptide binding]; other site 484022004312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022004313 catalytic residue [active] 484022004314 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 484022004315 Dehydratase family; Region: ILVD_EDD; cl00340 484022004316 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 484022004317 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 484022004318 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484022004319 PYR/PP interface [polypeptide binding]; other site 484022004320 dimer interface [polypeptide binding]; other site 484022004321 TPP binding site [chemical binding]; other site 484022004322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022004323 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 484022004324 TPP-binding site [chemical binding]; other site 484022004325 dimer interface [polypeptide binding]; other site 484022004326 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 484022004327 putative valine binding site [chemical binding]; other site 484022004328 dimer interface [polypeptide binding]; other site 484022004329 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 484022004330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022004331 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 484022004332 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 484022004333 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 484022004334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022004335 ATP binding site [chemical binding]; other site 484022004336 putative Mg++ binding site [ion binding]; other site 484022004337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022004338 nucleotide binding region [chemical binding]; other site 484022004339 ATP-binding site [chemical binding]; other site 484022004340 TRCF domain; Region: TRCF; pfam03461 484022004341 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 484022004342 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004343 Integrase core domain; Region: rve; cl01316 484022004344 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 484022004345 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 484022004346 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484022004347 minor groove reading motif; other site 484022004348 helix-hairpin-helix signature motif; other site 484022004349 substrate binding pocket [chemical binding]; other site 484022004350 active site 484022004351 electron transport complex protein RnfB; Provisional; Region: PRK05113 484022004352 Putative Fe-S cluster; Region: FeS; pfam04060 484022004353 4Fe-4S binding domain; Region: Fer4; cl02805 484022004354 glutaredoxin 2; Provisional; Region: PRK10387 484022004355 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022004356 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 484022004357 substrate binding pocket (H-site) [chemical binding]; other site 484022004358 N-terminal domain interface [polypeptide binding]; other site 484022004359 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 484022004360 nucleophile elbow; other site 484022004361 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004362 Integrase core domain; Region: rve; cl01316 484022004363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022004364 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022004365 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 484022004366 Ferritin-like domain; Region: Ferritin; pfam00210 484022004367 ferroxidase diiron center [ion binding]; other site 484022004368 lipoyl synthase; Provisional; Region: PRK05481 484022004369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 484022004370 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 484022004371 conserved cys residue [active] 484022004372 Domain of unknown function DUF28; Region: DUF28; cl00361 484022004373 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 484022004374 active site 484022004375 putative DNA-binding cleft [nucleotide binding]; other site 484022004376 dimer interface [polypeptide binding]; other site 484022004377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022004379 putative substrate translocation pore; other site 484022004380 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 484022004381 RuvA N terminal domain; Region: RuvA_N; pfam01330 484022004382 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 484022004383 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 484022004384 RmuC family; Region: RmuC; pfam02646 484022004385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022004386 dimerization interface [polypeptide binding]; other site 484022004387 putative Zn2+ binding site [ion binding]; other site 484022004388 putative DNA binding site [nucleotide binding]; other site 484022004389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 484022004390 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 484022004391 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 484022004392 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022004393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004394 putative substrate translocation pore; other site 484022004395 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_1; cd06251 484022004396 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 484022004397 putative active site [active] 484022004398 Zn-binding site [ion binding]; other site 484022004399 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 484022004400 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 484022004401 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 484022004402 5S rRNA interface [nucleotide binding]; other site 484022004403 CTC domain interface; other site 484022004404 L16 interface [polypeptide binding]; other site 484022004405 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 484022004406 Domain of unknown function DUF21; Region: DUF21; pfam01595 484022004407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484022004408 Transporter associated domain; Region: CorC_HlyC; pfam03471 484022004409 GTP-binding protein YchF; Reviewed; Region: PRK09601 484022004410 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 484022004411 G1 box; other site 484022004412 GTP/Mg2+ binding site [chemical binding]; other site 484022004413 Switch I region; other site 484022004414 G2 box; other site 484022004415 Switch II region; other site 484022004416 G3 box; other site 484022004417 G4 box; other site 484022004418 G5 box; other site 484022004419 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 484022004420 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 484022004421 putative active site [active] 484022004422 catalytic residue [active] 484022004423 Beta-lactamase; Region: Beta-lactamase; cl01009 484022004424 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 484022004425 dimerization domain [polypeptide binding]; other site 484022004426 dimer interface [polypeptide binding]; other site 484022004427 catalytic residues [active] 484022004428 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 484022004429 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 484022004430 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 484022004431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022004432 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022004433 Uncharacterized conserved protein [Function unknown]; Region: COG2898 484022004434 Ion channel; Region: Ion_trans_2; cl11596 484022004435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022004436 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022004437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022004438 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 484022004439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022004440 Walker A motif; other site 484022004441 ATP binding site [chemical binding]; other site 484022004442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022004443 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 484022004444 active site 484022004445 HslU subunit interaction site [polypeptide binding]; other site 484022004446 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 484022004447 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 484022004448 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 484022004449 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 484022004450 active site 484022004451 HIGH motif; other site 484022004452 dimer interface [polypeptide binding]; other site 484022004453 KMSKS motif; other site 484022004454 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 484022004455 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 484022004456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022004457 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 484022004458 dimerization interface [polypeptide binding]; other site 484022004459 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 484022004460 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 484022004461 phosphate binding site [ion binding]; other site 484022004462 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 484022004463 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 484022004464 dimer interface [polypeptide binding]; other site 484022004465 PYR/PP interface [polypeptide binding]; other site 484022004466 TPP binding site [chemical binding]; other site 484022004467 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022004468 TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize...; Region: TPP_PDC_IPDC; cd02005 484022004469 TPP-binding site [chemical binding]; other site 484022004470 dimer interface [polypeptide binding]; other site 484022004471 TOMM propeptide domain; Region: TOMM_pelo; TIGR03793 484022004472 TOMM propeptide domain; Region: TOMM_pelo; TIGR03793 484022004473 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022004474 FAD binding domain; Region: FAD_binding_4; pfam01565 484022004475 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 484022004476 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022004477 RNA binding surface [nucleotide binding]; other site 484022004478 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 484022004479 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 484022004480 Fusaric acid resistance protein family; Region: FUSC; pfam04632 484022004481 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484022004482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022004483 Transcriptional regulator [Transcription]; Region: IclR; COG1414 484022004484 Bacterial transcriptional regulator; Region: IclR; pfam01614 484022004485 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 484022004486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 484022004487 FeS/SAM binding site; other site 484022004488 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004489 Integrase core domain; Region: rve; cl01316 484022004490 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 484022004491 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 484022004492 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484022004493 NAD(P) binding site [chemical binding]; other site 484022004494 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 484022004495 DNA-binding site [nucleotide binding]; DNA binding site 484022004496 RNA-binding motif; other site 484022004497 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 484022004498 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 484022004499 active site 484022004500 DNA polymerase IV; Validated; Region: PRK02406 484022004501 DNA binding site [nucleotide binding] 484022004502 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 484022004503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022004504 Walker A/P-loop; other site 484022004505 ATP binding site [chemical binding]; other site 484022004506 Q-loop/lid; other site 484022004507 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 484022004508 ABC transporter signature motif; other site 484022004509 Walker B; other site 484022004510 D-loop; other site 484022004511 ABC transporter; Region: ABC_tran_2; pfam12848 484022004512 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 484022004513 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 484022004514 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 484022004515 GSH binding site [chemical binding]; other site 484022004516 catalytic residues [active] 484022004517 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 484022004518 dimer interface [polypeptide binding]; other site 484022004519 putative radical transfer pathway; other site 484022004520 diiron center [ion binding]; other site 484022004521 tyrosyl radical; other site 484022004522 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 484022004523 GSH binding site [chemical binding]; other site 484022004524 catalytic residues [active] 484022004525 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 484022004526 Class I ribonucleotide reductase; Region: RNR_I; cd01679 484022004527 active site 484022004528 dimer interface [polypeptide binding]; other site 484022004529 catalytic residues [active] 484022004530 effector binding site; other site 484022004531 R2 peptide binding site; other site 484022004532 malate dehydrogenase; Reviewed; Region: PRK06223 484022004533 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 484022004534 NAD(P) binding site [chemical binding]; other site 484022004535 dimer interface [polypeptide binding]; other site 484022004536 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484022004537 substrate binding site [chemical binding]; other site 484022004538 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 484022004539 diiron binding motif [ion binding]; other site 484022004540 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 484022004541 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022004542 catalytic residue [active] 484022004543 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 484022004544 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 484022004545 putative ATP binding site [chemical binding]; other site 484022004546 putative substrate interface [chemical binding]; other site 484022004547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022004548 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 484022004549 peroxidase; Provisional; Region: PRK15000 484022004550 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 484022004551 dimer interface [polypeptide binding]; other site 484022004552 decamer (pentamer of dimers) interface [polypeptide binding]; other site 484022004553 catalytic triad [active] 484022004554 peroxidatic and resolving cysteines [active] 484022004555 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 484022004556 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 484022004557 PhnA protein; Region: PhnA; pfam03831 484022004558 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 484022004559 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 484022004560 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 484022004561 active site 484022004562 substrate binding site [chemical binding]; other site 484022004563 catalytic site [active] 484022004564 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 484022004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 484022004566 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 484022004567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022004568 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 484022004569 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 484022004570 tetrameric interface [polypeptide binding]; other site 484022004571 NAD binding site [chemical binding]; other site 484022004572 catalytic residues [active] 484022004573 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 484022004574 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 484022004575 putative homotetramer interface [polypeptide binding]; other site 484022004576 putative homodimer interface [polypeptide binding]; other site 484022004577 putative allosteric switch controlling residues; other site 484022004578 putative metal binding site [ion binding]; other site 484022004579 putative homodimer-homodimer interface [polypeptide binding]; other site 484022004580 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022004581 Multicopper oxidase; Region: Cu-oxidase; cl14658 484022004582 Multicopper oxidase; Region: Cu-oxidase; cl14658 484022004583 Multicopper oxidase; Region: Cu-oxidase; cl14658 484022004584 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 484022004585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022004586 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 484022004587 dimerization interface [polypeptide binding]; other site 484022004588 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 484022004589 catalytic triad [active] 484022004590 dimer interface [polypeptide binding]; other site 484022004591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022004592 NAD(P) binding site [chemical binding]; other site 484022004593 active site 484022004594 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 484022004595 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 484022004596 tetramer interface [polypeptide binding]; other site 484022004597 heme binding pocket [chemical binding]; other site 484022004598 NADPH binding site [chemical binding]; other site 484022004599 Chorismate mutase type II; Region: CM_2; cl00693 484022004600 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 484022004601 catalytic residues [active] 484022004602 dimer interface [polypeptide binding]; other site 484022004603 Protein of unknown function (DUF819); Region: DUF819; cl02317 484022004604 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 484022004605 active site 484022004606 Putative serine esterase (DUF676); Region: DUF676; pfam05057 484022004607 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 484022004608 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 484022004609 putative substrate binding site [chemical binding]; other site 484022004610 putative ATP binding site [chemical binding]; other site 484022004611 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 484022004612 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 484022004613 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 484022004614 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 484022004615 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 484022004616 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 484022004617 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 484022004618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 484022004619 FeS/SAM binding site; other site 484022004620 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 484022004621 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 484022004622 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 484022004623 active site 484022004624 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022004625 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 484022004626 active site 484022004627 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 484022004628 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 484022004629 choline transport protein BetT; Provisional; Region: PRK09928 484022004630 BCCT family transporter; Region: BCCT; cl00569 484022004631 TspO/MBR family; Region: TspO_MBR; cl01379 484022004632 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 484022004633 SelR domain; Region: SelR; cl00369 484022004634 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 484022004635 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022004636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004637 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022004638 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a...; Region: DsbA_Com1_like; cd03023 484022004639 catalytic residues [active] 484022004640 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022004641 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 484022004642 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 484022004643 Domain of unknown function DUF143; Region: DUF143; cl00519 484022004644 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 484022004645 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022004646 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 484022004647 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 484022004648 motif 1; other site 484022004649 active site 484022004650 motif 2; other site 484022004651 motif 3; other site 484022004652 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 484022004653 DHHA1 domain; Region: DHHA1; pfam02272 484022004654 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 484022004655 Outer membrane efflux protein; Region: OEP; pfam02321 484022004656 Outer membrane efflux protein; Region: OEP; pfam02321 484022004657 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 484022004658 interface (dimer of trimers) [polypeptide binding]; other site 484022004659 Substrate-binding/catalytic site; other site 484022004660 Zn-binding sites [ion binding]; other site 484022004661 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 484022004662 transaldolase-like protein; Provisional; Region: PTZ00411 484022004663 active site 484022004664 dimer interface [polypeptide binding]; other site 484022004665 catalytic residue [active] 484022004666 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 484022004667 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 484022004668 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 484022004669 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022004670 UvrD/REP helicase; Region: UvrD-helicase; cl14126 484022004671 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 484022004672 peroxiredoxin; Provisional; Region: PRK13189 484022004673 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 484022004674 dimer interface [polypeptide binding]; other site 484022004675 decamer (pentamer of dimers) interface [polypeptide binding]; other site 484022004676 catalytic triad [active] 484022004677 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 484022004678 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 484022004679 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 484022004680 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 484022004681 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 484022004682 replicative DNA helicase; Region: DnaB; TIGR00665 484022004683 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 484022004684 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 484022004685 Walker A motif; other site 484022004686 ATP binding site [chemical binding]; other site 484022004687 Walker B motif; other site 484022004688 DNA binding loops [nucleotide binding] 484022004689 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 484022004690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 484022004691 FeS/SAM binding site; other site 484022004692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 484022004693 binding surface 484022004694 TPR motif; other site 484022004695 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 484022004696 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 484022004697 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022004698 RNA binding surface [nucleotide binding]; other site 484022004699 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 484022004700 probable active site [active] 484022004701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 484022004702 PQ loop repeat; Region: PQ-loop; cl12056 484022004703 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 484022004704 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 484022004705 substrate binding pocket [chemical binding]; other site 484022004706 chain length determination region; other site 484022004707 substrate-Mg2+ binding site; other site 484022004708 catalytic residues [active] 484022004709 aspartate-rich region 1; other site 484022004710 active site lid residues [active] 484022004711 aspartate-rich region 2; other site 484022004712 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022004713 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 484022004714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 484022004715 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 484022004716 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 484022004717 Ligand Binding Site [chemical binding]; other site 484022004718 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 484022004719 active site 484022004720 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 484022004721 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022004722 catalytic residue [active] 484022004723 Beta-lactamase; Region: Beta-lactamase; cl01009 484022004724 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 484022004725 GatB domain; Region: GatB_Yqey; cl11497 484022004726 DNA primase; Validated; Region: dnaG; PRK05667 484022004727 CHC2 zinc finger; Region: zf-CHC2; cl02597 484022004728 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 484022004729 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 484022004730 active site 484022004731 metal binding site [ion binding]; metal-binding site 484022004732 interdomain interaction site; other site 484022004733 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 484022004734 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 484022004735 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 484022004736 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 484022004737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484022004738 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 484022004739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 484022004740 DNA binding residues [nucleotide binding] 484022004741 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022004742 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 484022004743 Protein of unknown function (DUF493); Region: DUF493; cl01102 484022004744 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 484022004745 Beta-lactamase; Region: Beta-lactamase; cl01009 484022004746 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 484022004747 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 484022004748 dimer interface [polypeptide binding]; other site 484022004749 substrate binding site [chemical binding]; other site 484022004750 metal binding sites [ion binding]; metal-binding site 484022004751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022004752 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 484022004753 OstA-like protein; Region: OstA; cl00844 484022004754 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 484022004755 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 484022004756 Walker A/P-loop; other site 484022004757 ATP binding site [chemical binding]; other site 484022004758 Q-loop/lid; other site 484022004759 ABC transporter signature motif; other site 484022004760 Walker B; other site 484022004761 D-loop; other site 484022004762 H-loop/switch region; other site 484022004763 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 484022004764 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484022004765 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 484022004766 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 484022004767 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 484022004768 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 484022004769 dimerization interface 3.5A [polypeptide binding]; other site 484022004770 active site 484022004771 GMP synthase; Reviewed; Region: guaA; PRK00074 484022004772 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 484022004773 AMP/PPi binding site [chemical binding]; other site 484022004774 candidate oxyanion hole; other site 484022004775 catalytic triad [active] 484022004776 potential glutamine specificity residues [chemical binding]; other site 484022004777 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 484022004778 ATP Binding subdomain [chemical binding]; other site 484022004779 Ligand Binding sites [chemical binding]; other site 484022004780 Dimerization subdomain; other site 484022004781 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 484022004782 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 484022004783 TPP-binding site; other site 484022004784 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484022004785 PYR/PP interface [polypeptide binding]; other site 484022004786 dimer interface [polypeptide binding]; other site 484022004787 TPP binding site [chemical binding]; other site 484022004788 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484022004789 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 484022004790 active site 484022004791 catalytic triad [active] 484022004792 oxyanion hole [active] 484022004793 switch loop; other site 484022004794 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 484022004795 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 484022004796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 484022004797 Walker A motif; other site 484022004798 ATP binding site [chemical binding]; other site 484022004799 Walker B motif; other site 484022004800 arginine finger; other site 484022004801 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 484022004802 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 484022004803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 484022004804 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 484022004805 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 484022004806 catalytic motif [active] 484022004807 Catalytic residue [active] 484022004808 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 484022004809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022004810 EamA-like transporter family; Region: EamA; cl01037 484022004811 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484022004812 EamA-like transporter family; Region: EamA; cl01037 484022004813 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 484022004814 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 484022004815 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 484022004816 dimer interface [polypeptide binding]; other site 484022004817 motif 1; other site 484022004818 active site 484022004819 motif 2; other site 484022004820 motif 3; other site 484022004821 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 484022004822 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 484022004823 putative tRNA-binding site [nucleotide binding]; other site 484022004824 B3/4 domain; Region: B3_4; cl11458 484022004825 tRNA synthetase B5 domain; Region: B5; cl08394 484022004826 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 484022004827 dimer interface [polypeptide binding]; other site 484022004828 motif 1; other site 484022004829 motif 3; other site 484022004830 motif 2; other site 484022004831 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 484022004832 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 484022004833 metal binding site 2 [ion binding]; metal-binding site 484022004834 putative DNA binding helix; other site 484022004835 metal binding site 1 [ion binding]; metal-binding site 484022004836 dimer interface [polypeptide binding]; other site 484022004837 structural Zn2+ binding site [ion binding]; other site 484022004838 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 484022004839 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 484022004840 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 484022004841 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 484022004842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 484022004843 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 484022004844 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 484022004845 putative active site [active] 484022004846 catalytic site [active] 484022004847 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 484022004848 putative active site [active] 484022004849 catalytic site [active] 484022004850 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 484022004851 putative active site [active] 484022004852 catalytic site [active] 484022004853 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 484022004854 putative active site [active] 484022004855 catalytic site [active] 484022004856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004857 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022004858 putative substrate translocation pore; other site 484022004859 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 484022004860 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 484022004861 Walker A motif; other site 484022004862 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484022004863 trimer interface [polypeptide binding]; other site 484022004864 active site 484022004865 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 484022004866 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004867 Integrase core domain; Region: rve; cl01316 484022004868 multiple promoter invertase; Provisional; Region: mpi; PRK13413 484022004869 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 484022004870 catalytic residues [active] 484022004871 catalytic nucleophile [active] 484022004872 Presynaptic Site I dimer interface [polypeptide binding]; other site 484022004873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 484022004874 Synaptic Flat tetramer interface [polypeptide binding]; other site 484022004875 Synaptic Site I dimer interface [polypeptide binding]; other site 484022004876 DNA binding site [nucleotide binding] 484022004877 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 484022004878 catalytic residues [active] 484022004879 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484022004880 Sulfate transporter family; Region: Sulfate_transp; cl00967 484022004881 Sulfate transporter family; Region: Sulfate_transp; cl00967 484022004882 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 484022004883 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022004884 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004885 Integrase core domain; Region: rve; cl01316 484022004886 Lipopolysaccharide-assembly; Region: LptE; cl01125 484022004887 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 484022004888 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 484022004889 HIGH motif; other site 484022004890 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022004891 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022004892 active site 484022004893 KMSKS motif; other site 484022004894 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 484022004895 tRNA binding surface [nucleotide binding]; other site 484022004896 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 484022004897 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 484022004898 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 484022004899 active site 484022004900 8-oxo-dGMP binding site [chemical binding]; other site 484022004901 nudix motif; other site 484022004902 metal binding site [ion binding]; metal-binding site 484022004903 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022004904 Amino acid permease; Region: AA_permease; pfam00324 484022004905 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 484022004906 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484022004907 catalytic residues [active] 484022004908 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 484022004909 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 484022004910 FeS assembly ATPase SufC; Region: sufC; TIGR01978 484022004911 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 484022004912 Walker A/P-loop; other site 484022004913 ATP binding site [chemical binding]; other site 484022004914 Q-loop/lid; other site 484022004915 ABC transporter signature motif; other site 484022004916 Walker B; other site 484022004917 D-loop; other site 484022004918 H-loop/switch region; other site 484022004919 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 484022004920 putative ABC transporter; Region: ycf24; CHL00085 484022004921 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 484022004922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022004923 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 484022004924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022004925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022004926 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 484022004927 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022004928 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 484022004929 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 484022004930 rRNA binding site [nucleotide binding]; other site 484022004931 predicted 30S ribosome binding site; other site 484022004932 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 484022004933 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 484022004934 signal recognition particle protein; Provisional; Region: PRK10867 484022004935 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 484022004936 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 484022004937 P loop; other site 484022004938 GTP binding site [chemical binding]; other site 484022004939 Signal peptide binding domain; Region: SRP_SPB; pfam02978 484022004940 NeuB family; Region: NeuB; cl00496 484022004941 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484022004942 Bor protein; Region: Lambda_Bor; pfam06291 484022004943 Bor protein; Region: Lambda_Bor; pfam06291 484022004944 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 484022004945 An uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the the M14 family of metallocarboxypeptidases. This subgroup includes Pseudomonas aeruginosa AotO and related proteins. ASTE...; Region: M14_PaAOTO_like; cd06250 484022004946 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 484022004947 putative active site [active] 484022004948 Zn-binding site [ion binding]; other site 484022004949 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 484022004950 putative active site [active] 484022004951 putative DNA binding site [nucleotide binding]; other site 484022004952 putative phosphate binding site [ion binding]; other site 484022004953 putative catalytic site [active] 484022004954 metal binding site A [ion binding]; metal-binding site 484022004955 putative AP binding site [nucleotide binding]; other site 484022004956 putative metal binding site B [ion binding]; other site 484022004957 Nuclease-related domain; Region: NERD; pfam08378 484022004958 glutathione reductase; Validated; Region: PRK06116 484022004959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022004960 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022004961 Domain of unknown function (DUF74); Region: DUF74; cl00426 484022004962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022004963 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022004964 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 484022004965 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 484022004966 ATP binding site [chemical binding]; other site 484022004967 Mg++ binding site [ion binding]; other site 484022004968 motif III; other site 484022004969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022004970 nucleotide binding region [chemical binding]; other site 484022004971 ATP-binding site [chemical binding]; other site 484022004972 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 484022004973 GTP cyclohydrolase I; Provisional; Region: PLN03044 484022004974 active site 484022004975 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484022004976 putative active site [active] 484022004977 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 484022004978 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484022004979 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 484022004980 active site 484022004981 catalytic triad [active] 484022004982 dimer interface [polypeptide binding]; other site 484022004983 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 484022004984 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 484022004985 active site 484022004986 catalytic tetrad [active] 484022004987 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 484022004988 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 484022004989 active site 484022004990 catalytic tetrad [active] 484022004991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 484022004992 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 484022004993 Glutamine amidotransferase class-I; Region: GATase; pfam00117 484022004994 glutamine binding [chemical binding]; other site 484022004995 catalytic triad [active] 484022004996 chorismate binding enzyme; Region: Chorismate_bind; cl10555 484022004997 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 484022004998 substrate-cofactor binding pocket; other site 484022004999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022005000 homodimer interface [polypeptide binding]; other site 484022005001 catalytic residue [active] 484022005002 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 484022005003 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 484022005004 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 484022005005 active site 484022005006 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 484022005007 catalytic center binding site [active] 484022005008 ATP binding site [chemical binding]; other site 484022005009 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 484022005010 dihydropteroate synthase; Region: DHPS; TIGR01496 484022005011 substrate binding pocket [chemical binding]; other site 484022005012 dimer interface [polypeptide binding]; other site 484022005013 inhibitor binding site; inhibition site 484022005014 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 484022005015 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 484022005016 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 484022005017 CoenzymeA binding site [chemical binding]; other site 484022005018 subunit interaction site [polypeptide binding]; other site 484022005019 PHB binding site; other site 484022005020 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 484022005021 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 484022005022 inhibitor-cofactor binding pocket; inhibition site 484022005023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022005024 catalytic residue [active] 484022005025 Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502 484022005026 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 484022005027 FeS/SAM binding site; other site 484022005028 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 484022005029 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 484022005030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484022005031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022005032 catalytic residue [active] 484022005033 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 484022005034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022005035 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: PLN02974 484022005036 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 484022005037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022005038 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 484022005039 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 484022005040 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022005041 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 484022005042 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 484022005043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005044 putative substrate translocation pore; other site 484022005045 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 484022005046 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 484022005047 classical (c) SDRs; Region: SDR_c; cd05233 484022005048 NAD(P) binding site [chemical binding]; other site 484022005049 active site 484022005050 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 484022005051 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 484022005052 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 484022005053 heme-binding site [chemical binding]; other site 484022005054 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 484022005055 FAD binding pocket [chemical binding]; other site 484022005056 FAD binding motif [chemical binding]; other site 484022005057 phosphate binding motif [ion binding]; other site 484022005058 beta-alpha-beta structure motif; other site 484022005059 NAD binding pocket [chemical binding]; other site 484022005060 Heme binding pocket [chemical binding]; other site 484022005061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 484022005062 Rrf2 family protein; Region: rrf2_super; TIGR00738 484022005063 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 484022005064 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 484022005065 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 484022005066 inhibitor-cofactor binding pocket; inhibition site 484022005067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022005068 catalytic residue [active] 484022005069 glutathione synthetase; Provisional; Region: PRK05246 484022005070 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 484022005071 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 484022005072 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 484022005073 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 484022005074 putative active site [active] 484022005075 substrate binding site [chemical binding]; other site 484022005076 putative cosubstrate binding site; other site 484022005077 catalytic site [active] 484022005078 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 484022005079 substrate binding site [chemical binding]; other site 484022005080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022005081 dimerization interface [polypeptide binding]; other site 484022005082 putative DNA binding site [nucleotide binding]; other site 484022005083 putative Zn2+ binding site [ion binding]; other site 484022005084 Membrane transport protein; Region: Mem_trans; cl09117 484022005085 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 484022005086 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 484022005087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022005088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022005089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 484022005090 integrase; Provisional; Region: PRK09692 484022005091 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 484022005092 active site 484022005093 Int/Topo IB signature motif; other site 484022005094 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 484022005095 Virulence protein [General function prediction only]; Region: COG3943 484022005096 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 484022005097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022005098 ATP binding site [chemical binding]; other site 484022005099 putative Mg++ binding site [ion binding]; other site 484022005100 T5orf172 domain; Region: T5orf172; pfam10544 484022005101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484022005102 non-specific DNA binding site [nucleotide binding]; other site 484022005103 salt bridge; other site 484022005104 sequence-specific DNA binding site [nucleotide binding]; other site 484022005105 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 484022005106 Antirestriction protein (ArdA); Region: ArdA; cl01953 484022005107 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 484022005108 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 484022005109 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 484022005110 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 484022005111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 484022005112 Putative exonuclease, RdgC; Region: RdgC; cl01122 484022005113 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 484022005114 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 484022005115 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 484022005116 active site residue [active] 484022005117 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 484022005118 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484022005119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022005120 catalytic residue [active] 484022005121 cytidylate kinase; Provisional; Region: cmk; PRK00023 484022005122 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 484022005123 CMP-binding site; other site 484022005124 The sites determining sugar specificity; other site 484022005125 Cupin domain; Region: Cupin_2; cl09118 484022005126 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 484022005127 active site 484022005128 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 484022005129 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 484022005130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 484022005131 domain; Region: Succ_DH_flav_C; pfam02910 484022005132 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 484022005133 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 484022005134 dimerization interface [polypeptide binding]; other site 484022005135 active site 484022005136 Quinolinate synthetase A protein; Region: NadA; cl00420 484022005137 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 484022005138 catalytic site [active] 484022005139 G-X2-G-X-G-K; other site 484022005140 helicase 45; Provisional; Region: PTZ00424 484022005141 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 484022005142 ATP binding site [chemical binding]; other site 484022005143 Mg++ binding site [ion binding]; other site 484022005144 motif III; other site 484022005145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022005146 nucleotide binding region [chemical binding]; other site 484022005147 ATP-binding site [chemical binding]; other site 484022005148 DbpA RNA binding domain; Region: DbpA; pfam03880 484022005149 PPIC-type PPIASE domain; Region: Rotamase; cl08278 484022005150 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484022005151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005152 putative substrate translocation pore; other site 484022005153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005154 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 484022005155 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 484022005156 dimer interface [polypeptide binding]; other site 484022005157 active site 484022005158 galactokinase; Provisional; Region: PRK05322 484022005159 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 484022005160 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 484022005161 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 484022005162 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005163 Integrase core domain; Region: rve; cl01316 484022005164 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 484022005165 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 484022005166 Ligand binding site [chemical binding]; other site 484022005167 oligomer interface [polypeptide binding]; other site 484022005168 Trm112p-like protein; Region: Trm112p; cl01066 484022005169 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 484022005170 Ligand Binding Site [chemical binding]; other site 484022005171 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 484022005172 CPxP motif; other site 484022005173 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 484022005174 active site 484022005175 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 484022005176 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 484022005177 UvrB/uvrC motif; Region: UVR; pfam02151 484022005178 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 484022005179 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 484022005180 ribonuclease D; Region: rnd; TIGR01388 484022005181 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 484022005182 putative active site [active] 484022005183 catalytic site [active] 484022005184 putative substrate binding site [chemical binding]; other site 484022005185 HRDC domain; Region: HRDC; cl02578 484022005186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005187 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022005188 putative substrate translocation pore; other site 484022005189 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 484022005190 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 484022005191 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 484022005192 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484022005193 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484022005194 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 484022005195 active site 484022005196 recombination protein F; Reviewed; Region: recF; PRK00064 484022005197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022005198 Walker A/P-loop; other site 484022005199 ATP binding site [chemical binding]; other site 484022005200 Q-loop/lid; other site 484022005201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 484022005202 ABC transporter signature motif; other site 484022005203 Walker B; other site 484022005204 D-loop; other site 484022005205 H-loop/switch region; other site 484022005206 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 484022005207 EamA-like transporter family; Region: EamA; cl01037 484022005208 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484022005209 EamA-like transporter family; Region: EamA; cl01037 484022005210 acetyl-CoA synthetase; Provisional; Region: PRK00174 484022005211 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 484022005212 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 484022005213 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 484022005214 active site 484022005215 tetramer interface [polypeptide binding]; other site 484022005216 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 484022005217 Cation efflux family; Region: Cation_efflux; cl00316 484022005218 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005219 Integrase core domain; Region: rve; cl01316 484022005220 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005221 Integrase core domain; Region: rve; cl01316 484022005222 Restriction endonuclease [Defense mechanisms]; Region: COG3587 484022005223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 484022005224 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 484022005225 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005226 Integrase core domain; Region: rve; cl01316 484022005227 Antirestriction protein (ArdA); Region: ArdA; cl01953 484022005228 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 484022005229 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 484022005230 FMN binding site [chemical binding]; other site 484022005231 active site 484022005232 catalytic residues [active] 484022005233 substrate binding site [chemical binding]; other site 484022005234 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 484022005235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 484022005236 S-adenosylmethionine binding site [chemical binding]; other site 484022005237 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 484022005238 ferrochelatase; Reviewed; Region: hemH; PRK00035 484022005239 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 484022005240 C-terminal domain interface [polypeptide binding]; other site 484022005241 active site 484022005242 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 484022005243 active site 484022005244 N-terminal domain interface [polypeptide binding]; other site 484022005245 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 484022005246 DNA photolyase; Region: DNA_photolyase; pfam00875 484022005247 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 484022005248 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 484022005249 substrate binding pocket [chemical binding]; other site 484022005250 dimer interface [polypeptide binding]; other site 484022005251 metal binding site [ion binding]; metal-binding site 484022005252 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 484022005253 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 484022005254 active site 484022005255 catalytic residues [active] 484022005256 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 484022005257 Flavoprotein; Region: Flavoprotein; cl08021 484022005258 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 484022005259 benzoate transport; Region: 2A0115; TIGR00895 484022005260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005261 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022005262 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 484022005263 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 484022005264 Proline dehydrogenase; Region: Pro_dh; cl03282 484022005265 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 484022005266 Glutamate binding site [chemical binding]; other site 484022005267 NAD binding site [chemical binding]; other site 484022005268 catalytic residues [active] 484022005269 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484022005270 NAD(P) binding site [chemical binding]; other site 484022005271 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484022005272 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 484022005273 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 484022005274 metal binding site [ion binding]; metal-binding site