-- dump date 20120504_144728 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001890898.1 187930914 6291181 130..1521 1 NC_010677.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1521 dnaA 6291181 dnaA Francisella tularensis subsp. mediasiatica FSC147 chromosomal replication initiation protein YP_001890898.1 130 D 441952 CDS YP_001890899.1 187930915 6291114 1558..2661 1 NC_010677.1 DNA polymerase III subunit beta 2661 dnaN 6291114 dnaN Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase III subunit beta YP_001890899.1 1558 D 441952 CDS YP_001890900.1 187930916 6291081 complement(4828..6051) 1 NC_010677.1 serine permease 6051 sdaC 6291081 sdaC Francisella tularensis subsp. mediasiatica FSC147 serine permease YP_001890900.1 4828 R 441952 CDS YP_001890901.1 187930917 6290098 complement(6379..6615) 1 NC_010677.1 hypothetical protein 6615 6290098 FTM_0005 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890901.1 6379 R 441952 CDS YP_001890902.1 187930918 6290376 7112..7990 1 NC_010677.1 3-hydroxyisobutyrate dehydrogenase 7990 6290376 FTM_0006 Francisella tularensis subsp. mediasiatica FSC147 3-hydroxyisobutyrate dehydrogenase YP_001890902.1 7112 D 441952 CDS YP_001890903.1 187930919 6290658 complement(8004..8924) 1 NC_010677.1 aspartate carbamoyltransferase 8924 pyrB 6290658 pyrB Francisella tularensis subsp. mediasiatica FSC147 aspartate carbamoyltransferase YP_001890903.1 8004 R 441952 CDS YP_001890904.1 187930920 6290661 complement(9066..12350) 1 NC_010677.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 12350 carB 6290661 carB Francisella tularensis subsp. mediasiatica FSC147 carbamoyl phosphate synthase large subunit YP_001890904.1 9066 R 441952 CDS YP_001890905.1 187930921 6290666 complement(12355..13521) 1 NC_010677.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 13521 carA 6290666 carA Francisella tularensis subsp. mediasiatica FSC147 carbamoyl phosphate synthase small subunit YP_001890905.1 12355 R 441952 CDS YP_001890906.1 187930922 6290674 13937..14992 1 NC_010677.1 histidine acid phosphatase 14992 6290674 FTM_0010 Francisella tularensis subsp. mediasiatica FSC147 histidine acid phosphatase YP_001890906.1 13937 D 441952 CDS YP_001890907.1 187930923 6290679 complement(15116..15796) 1 NC_010677.1 catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide; thiopurine S-methyltransferase 15796 tmpT 6290679 tmpT Francisella tularensis subsp. mediasiatica FSC147 thiopurine S-methyltransferase YP_001890907.1 15116 R 441952 CDS YP_001890908.1 187930924 6290785 15928..17274 1 NC_010677.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 17274 pyrC 6290785 pyrC Francisella tularensis subsp. mediasiatica FSC147 dihydroorotase YP_001890908.1 15928 D 441952 CDS YP_001890909.1 187930925 6290787 complement(17302..18321) 1 NC_010677.1 regulatory protein ArsR 18321 6290787 FTM_0013 Francisella tularensis subsp. mediasiatica FSC147 regulatory protein ArsR YP_001890909.1 17302 R 441952 CDS YP_001890910.1 187930926 6290791 18592..18834 1 NC_010677.1 hypothetical protein 18834 6290791 FTM_0014 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890910.1 18592 D 441952 CDS YP_001890911.1 187930927 6290795 18881..19159 1 NC_010677.1 hypothetical protein 19159 6290795 FTM_0015 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890911.1 18881 D 441952 CDS YP_001890912.1 187930928 6291440 complement(20215..21267) 1 NC_010677.1 membrane protein 21267 6291440 FTM_0017 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890912.1 20215 R 441952 CDS YP_001890913.1 187930929 6290388 complement(21254..22219) 1 NC_010677.1 HlyD family secretion protein 22219 6290388 FTM_0018 Francisella tularensis subsp. mediasiatica FSC147 HlyD family secretion protein YP_001890913.1 21254 R 441952 CDS YP_001890914.1 187930930 6291587 complement(22308..22715) 1 NC_010677.1 membrane protein 22715 6291587 FTM_0019 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890914.1 22308 R 441952 CDS YP_001890915.1 187930931 6291242 22841..23710 1 NC_010677.1 transcriptional regulator, LysR family 23710 6291242 FTM_0020 Francisella tularensis subsp. mediasiatica FSC147 transcriptional regulator, LysR family YP_001890915.1 22841 D 441952 CDS YP_001890916.1 187930932 6291318 complement(23711..24337) 1 NC_010677.1 soul domain-containing protein 24337 6291318 FTM_0021 Francisella tularensis subsp. mediasiatica FSC147 soul domain-containing protein YP_001890916.1 23711 R 441952 CDS YP_001890917.1 187930933 6290060 24480..25028 1 NC_010677.1 chorismate mutase 25028 6290060 FTM_0022 Francisella tularensis subsp. mediasiatica FSC147 chorismate mutase YP_001890917.1 24480 D 441952 CDS YP_001890918.1 187930934 6290102 28727..29371 1 NC_010677.1 orotidine-5'-phosphate decarboxylase 29371 pyrF 6290102 pyrF Francisella tularensis subsp. mediasiatica FSC147 orotidine-5'-phosphate decarboxylase YP_001890918.1 28727 D 441952 CDS YP_001890919.1 187930935 6291220 29373..30119 1 NC_010677.1 diyroorotate dehydrogenase 30119 pyrD 6291220 pyrD Francisella tularensis subsp. mediasiatica FSC147 diyroorotate dehydrogenase YP_001890919.1 29373 D 441952 CDS YP_001890920.1 187930936 6290110 complement(30381..30860) 1 NC_010677.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 30860 dtd 6290110 dtd Francisella tularensis subsp. mediasiatica FSC147 D-tyrosyl-tRNA(Tyr) deacylase YP_001890920.1 30381 R 441952 CDS YP_001890921.1 187930937 6291395 complement(32312..33790) 1 NC_010677.1 beta-fructofuranosidase 33790 6291395 FTM_0028 Francisella tularensis subsp. mediasiatica FSC147 beta-fructofuranosidase YP_001890921.1 32312 R 441952 CDS YP_001890922.1 187930938 6291199 complement(35592..36257) 1 NC_010677.1 nitroreductase 36257 6291199 FTM_0030 Francisella tularensis subsp. mediasiatica FSC147 nitroreductase YP_001890922.1 35592 R 441952 CDS YP_001890923.1 187930939 6290976 36660..37352 1 NC_010677.1 hypothetical protein 37352 6290976 FTM_0031 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890923.1 36660 D 441952 CDS YP_001890924.1 187930940 6290903 complement(37349..38554) 1 NC_010677.1 hydroxy/aromatic amino acid permease 38554 6290903 FTM_0032 Francisella tularensis subsp. mediasiatica FSC147 hydroxy/aromatic amino acid permease YP_001890924.1 37349 R 441952 CDS YP_001890925.1 187930941 6290717 38663..39271 1 NC_010677.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 39271 gidB 6290717 gidB Francisella tularensis subsp. mediasiatica FSC147 16S rRNA methyltransferase GidB YP_001890925.1 38663 D 441952 CDS YP_001890926.1 187930942 6290882 39268..39936 1 NC_010677.1 hypothetical protein 39936 6290882 FTM_0034 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890926.1 39268 D 441952 CDS YP_001890927.1 187930943 6290858 complement(39929..40813) 1 NC_010677.1 membrane protein 40813 6290858 FTM_0035 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890927.1 39929 R 441952 CDS YP_001890928.1 187930944 6290021 complement(41015..41911) 1 NC_010677.1 transcription regulator, LysR family 41911 6290021 FTM_0036 Francisella tularensis subsp. mediasiatica FSC147 transcription regulator, LysR family YP_001890928.1 41015 R 441952 CDS YP_001890929.1 187930945 6290245 42014..43150 1 NC_010677.1 drug:H+ antiporter-1 (DHA1) family protein 43150 6290245 FTM_0037 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 (DHA1) family protein YP_001890929.1 42014 D 441952 CDS YP_001890930.1 187930946 6290563 45699..46295 1 NC_010677.1 phosphoheptose isomerase 46295 6290563 FTM_0039 Francisella tularensis subsp. mediasiatica FSC147 phosphoheptose isomerase YP_001890930.1 45699 D 441952 CDS YP_001890931.1 187930947 6291553 46303..46659 1 NC_010677.1 outer membrane lipoprotein 46659 6291553 FTM_0040 Francisella tularensis subsp. mediasiatica FSC147 outer membrane lipoprotein YP_001890931.1 46303 D 441952 CDS YP_001890932.1 187930948 6290507 complement(46733..47005) 1 NC_010677.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 47005 rpsT 6290507 rpsT Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S20 YP_001890932.1 46733 R 441952 CDS YP_001890933.1 187930949 6290886 47275..49068 1 NC_010677.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 49068 lepA 6290886 lepA Francisella tularensis subsp. mediasiatica FSC147 GTP-binding protein LepA YP_001890933.1 47275 D 441952 CDS YP_001890934.1 187930950 6290706 49074..50153 1 NC_010677.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 50153 mnmA 6290706 mnmA Francisella tularensis subsp. mediasiatica FSC147 tRNA-specific 2-thiouridylase MnmA YP_001890934.1 49074 D 441952 CDS YP_001890935.1 187930951 6290001 complement(50173..51150) 1 NC_010677.1 lipoprotein 51150 6290001 FTM_0044 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001890935.1 50173 R 441952 CDS YP_001890936.1 187930952 6290350 complement(51244..51762) 1 NC_010677.1 peptide deformylase 51762 6290350 FTM_0045 Francisella tularensis subsp. mediasiatica FSC147 peptide deformylase YP_001890936.1 51244 R 441952 CDS YP_001890937.1 187930953 6291289 complement(51765..52208) 1 NC_010677.1 6,7-dimethyl-8-ribityllumazine synthase 52208 ribH 6291289 ribH Francisella tularensis subsp. mediasiatica FSC147 6,7-dimethyl-8-ribityllumazine synthase YP_001890937.1 51765 R 441952 CDS YP_001890938.1 187930954 6291550 complement(52218..53429) 1 NC_010677.1 riboflavin biosynthesis protein ribAB 53429 6291550 FTM_0047 Francisella tularensis subsp. mediasiatica FSC147 riboflavin biosynthesis protein ribAB YP_001890938.1 52218 R 441952 CDS YP_001890939.1 187930955 6290652 complement(53422..54027) 1 NC_010677.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 54027 ribC 6290652 ribC Francisella tularensis subsp. mediasiatica FSC147 riboflavin synthase subunit alpha YP_001890939.1 53422 R 441952 CDS YP_001890940.1 187930956 6291110 complement(54020..55087) 1 NC_010677.1 riboflavin biosynthesis protein RibD 55087 ribD 6291110 ribD Francisella tularensis subsp. mediasiatica FSC147 riboflavin biosynthesis protein RibD YP_001890940.1 54020 R 441952 CDS YP_001890941.1 187930957 6290088 57620..58012 1 NC_010677.1 membrane protein 58012 6290088 FTM_0052 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890941.1 57620 D 441952 CDS YP_001890942.1 187930958 6291350 58033..58443 1 NC_010677.1 membrane protein 58443 6291350 FTM_0053 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890942.1 58033 D 441952 CDS YP_001890943.1 187930959 6290296 58937..60349 1 NC_010677.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 60349 eriC 6290296 eriC Francisella tularensis subsp. mediasiatica FSC147 chloride channel protein YP_001890943.1 58937 D 441952 CDS YP_001890944.1 187930960 6290673 61853..63043 1 NC_010677.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 63043 trpB 6290673 trpB Francisella tularensis subsp. mediasiatica FSC147 tryptophan synthase subunit beta YP_001890944.1 61853 D 441952 CDS YP_001890945.1 187930961 6290699 63043..63852 1 NC_010677.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 63852 trpA 6290699 trpA Francisella tularensis subsp. mediasiatica FSC147 tryptophan synthase subunit alpha YP_001890945.1 63043 D 441952 CDS YP_001890946.1 187930962 6290362 65278..67857 1 NC_010677.1 chaperone ClpB 67857 clpB 6290362 clpB Francisella tularensis subsp. mediasiatica FSC147 chaperone ClpB YP_001890946.1 65278 D 441952 CDS YP_001890947.1 187930963 6291290 68108..70300 1 NC_010677.1 chitinase 70300 chiB 6291290 chiB Francisella tularensis subsp. mediasiatica FSC147 chitinase YP_001890947.1 68108 D 441952 CDS YP_001890948.1 187930964 6290165 70354..71514 1 NC_010677.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 71514 purT 6290165 purT Francisella tularensis subsp. mediasiatica FSC147 phosphoribosylglycinamide formyltransferase 2 YP_001890948.1 70354 D 441952 CDS YP_001890949.1 187930965 6290259 complement(72203..72844) 1 NC_010677.1 membrane protein 72844 6290259 FTM_0065 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890949.1 72203 R 441952 CDS YP_001890950.1 187930966 6290654 73081..73404 1 NC_010677.1 ferredoxin-1 73404 6290654 FTM_0066 Francisella tularensis subsp. mediasiatica FSC147 ferredoxin-1 YP_001890950.1 73081 D 441952 CDS YP_001890951.1 187930967 6290465 73567..74319 1 NC_010677.1 acyltransferase 74319 6290465 FTM_0067 Francisella tularensis subsp. mediasiatica FSC147 acyltransferase YP_001890951.1 73567 D 441952 CDS YP_001890952.1 187930968 6291261 74333..75073 1 NC_010677.1 acyltransferase 75073 6291261 FTM_0068 Francisella tularensis subsp. mediasiatica FSC147 acyltransferase YP_001890952.1 74333 D 441952 CDS YP_001890953.1 187930969 6290641 complement(75079..75798) 1 NC_010677.1 hypothetical protein 75798 6290641 FTM_0069 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890953.1 75079 R 441952 CDS YP_001890954.1 187930970 6290040 complement(75863..77014) 1 NC_010677.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 77014 nhaA 6290040 nhaA Francisella tularensis subsp. mediasiatica FSC147 pH-dependent sodium/proton antiporter YP_001890954.1 75863 R 441952 CDS YP_001890955.1 187930971 6290544 77108..78004 1 NC_010677.1 rieske protein 78004 6290544 FTM_0071 Francisella tularensis subsp. mediasiatica FSC147 rieske protein YP_001890955.1 77108 D 441952 CDS YP_001890956.1 187930972 6290638 78070..78579 1 NC_010677.1 B-type cytochrome 78579 6290638 FTM_0072 Francisella tularensis subsp. mediasiatica FSC147 B-type cytochrome YP_001890956.1 78070 D 441952 CDS YP_001890957.1 187930973 6290972 82386..83246 1 NC_010677.1 galactose mutarotase 83246 6290972 FTM_0076 Francisella tularensis subsp. mediasiatica FSC147 galactose mutarotase YP_001890957.1 82386 D 441952 CDS YP_001890958.1 187930974 6290695 85014..86312 1 NC_010677.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 86312 purB 6290695 purB Francisella tularensis subsp. mediasiatica FSC147 adenylosuccinate lyase YP_001890958.1 85014 D 441952 CDS YP_001890959.1 187930975 6290733 86284..86925 1 NC_010677.1 hypothetical protein 86925 6290733 FTM_0080 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890959.1 86284 D 441952 CDS YP_001890960.1 187930976 6290751 87012..88553 1 NC_010677.1 ATP-binding cassette 88553 6290751 FTM_0081 Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette YP_001890960.1 87012 D 441952 CDS YP_001890961.1 187930977 6291528 88564..89634 1 NC_010677.1 membrane-fusion protein 89634 6291528 FTM_0082 Francisella tularensis subsp. mediasiatica FSC147 membrane-fusion protein YP_001890961.1 88564 D 441952 CDS YP_001890962.1 187930978 6290703 89717..89998 1 NC_010677.1 glutamyl-tRNA(Gln) amidotransferase subunit C 89998 gatC 6290703 gatC Francisella tularensis subsp. mediasiatica FSC147 glutamyl-tRNA(Gln) amidotransferase subunit C YP_001890962.1 89717 D 441952 CDS YP_001890963.1 187930979 6291177 90007..91452 1 NC_010677.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 91452 gatA 6291177 gatA Francisella tularensis subsp. mediasiatica FSC147 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_001890963.1 90007 D 441952 CDS YP_001890964.1 187930980 6290764 91455..92876 1 NC_010677.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 92876 gatB 6290764 gatB Francisella tularensis subsp. mediasiatica FSC147 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_001890964.1 91455 D 441952 CDS YP_001890965.1 187930981 6291115 92891..93298 1 NC_010677.1 hypothetical protein 93298 6291115 FTM_0086 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890965.1 92891 D 441952 CDS YP_001890966.1 187930982 6290247 complement(94855..96384) 1 NC_010677.1 membrane protein 96384 6290247 FTM_0088 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890966.1 94855 R 441952 CDS YP_001890967.1 187930983 6290468 complement(96470..97660) 1 NC_010677.1 drug:H+ antiporter-1 97660 6290468 FTM_0089 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 YP_001890967.1 96470 R 441952 CDS YP_001890968.1 187930984 6291504 complement(97676..98929) 1 NC_010677.1 diaminopimelate decarboxylase 98929 6291504 FTM_0090 Francisella tularensis subsp. mediasiatica FSC147 diaminopimelate decarboxylase YP_001890968.1 97676 R 441952 CDS YP_001890969.1 187930985 6290854 complement(98922..100184) 1 NC_010677.1 drug:H+ antiporter-1 100184 6290854 FTM_0091 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 YP_001890969.1 98922 R 441952 CDS YP_001890970.1 187930986 6291131 complement(100191..102110) 1 NC_010677.1 siderophore biosynthesis protein 102110 frgA 6291131 frgA Francisella tularensis subsp. mediasiatica FSC147 siderophore biosynthesis protein YP_001890970.1 100191 R 441952 CDS YP_001890971.1 187930987 6290677 complement(102363..102785) 1 NC_010677.1 ferric uptake regulation protein 102785 fur 6290677 fur Francisella tularensis subsp. mediasiatica FSC147 ferric uptake regulation protein YP_001890971.1 102363 R 441952 CDS YP_001890972.1 187930988 6290047 102993..103391 1 NC_010677.1 NADH dehydrogenase I subunit A 103391 nuoA 6290047 nuoA Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit A YP_001890972.1 102993 D 441952 CDS YP_001890973.1 187930989 6291122 103382..103858 1 NC_010677.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 103858 nuoB 6291122 nuoB Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase subunit B YP_001890973.1 103382 D 441952 CDS YP_001890974.1 187930990 6291447 103861..104505 1 NC_010677.1 NADH dehydrogenase I subunit C 104505 nuoC 6291447 nuoC Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit C YP_001890974.1 103861 D 441952 CDS YP_001890975.1 187930991 6290629 104527..105780 1 NC_010677.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 105780 nuoD 6290629 nuoD Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase subunit D YP_001890975.1 104527 D 441952 CDS YP_001890976.1 187930992 6291505 105790..106278 1 NC_010677.1 NADH dehydrogenase I subunit E 106278 nuoE 6291505 nuoE Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit E YP_001890976.1 105790 D 441952 CDS YP_001890977.1 187930993 6290644 106285..107559 1 NC_010677.1 NADH dehydrogenase I subunit F 107559 nuoF 6290644 nuoF Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit F YP_001890977.1 106285 D 441952 CDS YP_001890978.1 187930994 6290633 107577..109943 1 NC_010677.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 109943 nuoG 6290633 nuoG Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase subunit G YP_001890978.1 107577 D 441952 CDS YP_001890979.1 187930995 6290634 109945..110955 1 NC_010677.1 NADH dehydrogenase I subunit H 110955 nuoH 6290634 nuoH Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit H YP_001890979.1 109945 D 441952 CDS YP_001890980.1 187930996 6290377 110969..111457 1 NC_010677.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 111457 nuoI 6290377 nuoI Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase subunit I YP_001890980.1 110969 D 441952 CDS YP_001890981.1 187930997 6290161 111462..112067 1 NC_010677.1 NADH dehydrogenase I subunit J 112067 nuoJ 6290161 nuoJ Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit J YP_001890981.1 111462 D 441952 CDS YP_001890982.1 187930998 6290339 112060..112377 1 NC_010677.1 NADH dehydrogenase I subunit K 112377 nuoK 6290339 nuoK Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit K YP_001890982.1 112060 D 441952 CDS YP_001890983.1 187930999 6290832 112387..114396 1 NC_010677.1 NADH dehydrogenase I subunit L 114396 nuoL 6290832 nuoL Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit L YP_001890983.1 112387 D 441952 CDS YP_001890984.1 187931000 6290805 114422..116011 1 NC_010677.1 NADH dehydrogenase I subunit M 116011 nuoM 6290805 nuoM Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit M YP_001890984.1 114422 D 441952 CDS YP_001890985.1 187931001 6291488 116027..117478 1 NC_010677.1 NADH dehydrogenase I subunit N 117478 nuoN 6291488 nuoN Francisella tularensis subsp. mediasiatica FSC147 NADH dehydrogenase I subunit N YP_001890985.1 116027 D 441952 CDS YP_001890986.1 187931002 6290910 117554..117748 1 NC_010677.1 hypothetical protein 117748 6290910 FTM_0108 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890986.1 117554 D 441952 CDS YP_001890987.1 187931003 6290887 119311..120345 1 NC_010677.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 120345 hemE 6290887 hemE Francisella tularensis subsp. mediasiatica FSC147 uroporphyrinogen decarboxylase YP_001890987.1 119311 D 441952 CDS YP_001890988.1 187931004 6290309 120571..121023 1 NC_010677.1 hypothetical protein 121023 6290309 FTM_0112 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001890988.1 120571 D 441952 CDS YP_001890989.1 187931005 6290933 121041..122510 1 NC_010677.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 122510 nusA 6290933 nusA Francisella tularensis subsp. mediasiatica FSC147 transcription elongation factor NusA YP_001890989.1 121041 D 441952 CDS YP_001890990.1 187931006 6290237 122549..125089 1 NC_010677.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 125089 infB 6290237 infB Francisella tularensis subsp. mediasiatica FSC147 translation initiation factor IF-2 YP_001890990.1 122549 D 441952 CDS YP_001890991.1 187931007 6290698 125092..125523 1 NC_010677.1 ribosome-binding factor A 125523 rbfA 6290698 rbfA Francisella tularensis subsp. mediasiatica FSC147 ribosome-binding factor A YP_001890991.1 125092 D 441952 CDS YP_001890992.1 187931008 6290568 125531..126796 1 NC_010677.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 126796 hisS 6290568 hisS Francisella tularensis subsp. mediasiatica FSC147 histidyl-tRNA synthetase YP_001890992.1 125531 D 441952 CDS YP_001890993.1 187931009 6290765 126803..128101 1 NC_010677.1 major facilitator superfamily protein 128101 6290765 FTM_0117 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily protein YP_001890993.1 126803 D 441952 CDS YP_001890994.1 187931010 6290518 128104..129171 1 NC_010677.1 ATPase 129171 6290518 FTM_0118 Francisella tularensis subsp. mediasiatica FSC147 ATPase YP_001890994.1 128104 D 441952 CDS YP_001890995.1 187931011 6291198 129164..130093 1 NC_010677.1 ribosomal large subunit pseudouridine synthase C 130093 rluC 6291198 rluC Francisella tularensis subsp. mediasiatica FSC147 ribosomal large subunit pseudouridine synthase C YP_001890995.1 129164 D 441952 CDS YP_001890996.1 187931012 6291194 complement(130095..131399) 1 NC_010677.1 major facilitator superfamily protein 131399 6291194 FTM_0120 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily protein YP_001890996.1 130095 R 441952 CDS YP_001890997.1 187931013 6291423 131476..131907 1 NC_010677.1 membrane protein 131907 6291423 FTM_0121 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001890997.1 131476 D 441952 CDS YP_001890998.1 187931014 6290228 131960..132751 1 NC_010677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 132751 atpB 6290228 atpB Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit A YP_001890998.1 131960 D 441952 CDS YP_001890999.1 187931015 6290732 132802..133107 1 NC_010677.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 133107 atpE 6290732 atpE Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit C YP_001890999.1 132802 D 441952 CDS YP_001891000.1 187931016 6290205 133153..133623 1 NC_010677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 133623 atpF 6290205 atpF Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit B YP_001891000.1 133153 D 441952 CDS YP_001891001.1 187931017 6290293 133643..134167 1 NC_010677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 134167 atpH 6290293 atpH Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit delta YP_001891001.1 133643 D 441952 CDS YP_001891002.1 187931018 6290651 134186..135727 1 NC_010677.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 135727 atpA 6290651 atpA Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit alpha YP_001891002.1 134186 D 441952 CDS YP_001891003.1 187931019 6291293 135742..136638 1 NC_010677.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 136638 atpG 6291293 atpG Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit gamma YP_001891003.1 135742 D 441952 CDS YP_001891004.1 187931020 6290360 136648..138024 1 NC_010677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 138024 atpD 6290360 atpD Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit beta YP_001891004.1 136648 D 441952 CDS YP_001891005.1 187931021 6290959 138037..138474 1 NC_010677.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit epsilon 138474 atpC 6290959 atpC Francisella tularensis subsp. mediasiatica FSC147 F0F1 ATP synthase subunit epsilon YP_001891005.1 138037 D 441952 CDS YP_001891006.1 187931022 6291000 138685..141528 1 NC_010677.1 hypothetical protein 141528 6291000 FTM_0130 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891006.1 138685 D 441952 CDS YP_001891007.1 187931023 6291112 complement(141545..141874) 1 NC_010677.1 glutaredoxin-like protein 141874 6291112 FTM_0131 Francisella tularensis subsp. mediasiatica FSC147 glutaredoxin-like protein YP_001891007.1 141545 R 441952 CDS YP_001891008.1 187931024 6291328 142010..142588 1 NC_010677.1 iron/manganese superoxide dismutase family protein 142588 sodB 6291328 sodB Francisella tularensis subsp. mediasiatica FSC147 iron/manganese superoxide dismutase family protein YP_001891008.1 142010 D 441952 CDS YP_001891009.1 187931025 6291586 142600..142788 1 NC_010677.1 hypothetical protein 142788 6291586 FTM_0133 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891009.1 142600 D 441952 CDS YP_001891010.1 187931026 6291671 complement(142793..144058) 1 NC_010677.1 peptide-acetyl-coenzyme A transporter (PAT) family protein 144058 ampG 6291671 ampG Francisella tularensis subsp. mediasiatica FSC147 peptide-acetyl-coenzyme A transporter (PAT) family protein YP_001891010.1 142793 R 441952 CDS YP_001891011.1 187931027 6291165 complement(144148..145407) 1 NC_010677.1 citrate synthase I 145407 gltA 6291165 gltA Francisella tularensis subsp. mediasiatica FSC147 citrate synthase I YP_001891011.1 144148 R 441952 CDS YP_001891012.1 187931028 6290475 145665..146138 1 NC_010677.1 succinate dehydrogenase, cytochrome b556 subunit 146138 sdhC 6290475 sdhC Francisella tularensis subsp. mediasiatica FSC147 succinate dehydrogenase, cytochrome b556 subunit YP_001891012.1 145665 D 441952 CDS YP_001891013.1 187931029 6291254 146114..146482 1 NC_010677.1 succinate dehydrogenase, hydrophobic membrane anchor protein 146482 sdhD 6291254 sdhD Francisella tularensis subsp. mediasiatica FSC147 succinate dehydrogenase, hydrophobic membrane anchor protein YP_001891013.1 146114 D 441952 CDS YP_001891014.1 187931030 6290984 146495..148288 1 NC_010677.1 succinate dehydrogenase, flavoprotein subunit 148288 sdhA 6290984 sdhA Francisella tularensis subsp. mediasiatica FSC147 succinate dehydrogenase, flavoprotein subunit YP_001891014.1 146495 D 441952 CDS YP_001891015.1 187931031 6291540 148306..149007 1 NC_010677.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 149007 sdhB 6291540 sdhB Francisella tularensis subsp. mediasiatica FSC147 succinate dehydrogenase iron-sulfur subunit YP_001891015.1 148306 D 441952 CDS YP_001891016.1 187931032 6290849 149037..151850 1 NC_010677.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 151850 sucA 6290849 sucA Francisella tularensis subsp. mediasiatica FSC147 2-oxoglutarate dehydrogenase E1 component YP_001891016.1 149037 D 441952 CDS YP_001891017.1 187931033 6290808 151876..153345 1 NC_010677.1 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase 153345 sucB 6290808 sucB Francisella tularensis subsp. mediasiatica FSC147 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase YP_001891017.1 151876 D 441952 CDS YP_001891018.1 187931034 6290574 153385..153912 1 NC_010677.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 153912 apt 6290574 apt Francisella tularensis subsp. mediasiatica FSC147 adenine phosphoribosyltransferase YP_001891018.1 153385 D 441952 CDS YP_001891019.1 187931035 6290434 153923..155254 1 NC_010677.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 155254 glmM 6290434 glmM Francisella tularensis subsp. mediasiatica FSC147 phosphoglucosamine mutase YP_001891019.1 153923 D 441952 CDS YP_001891020.1 187931036 6291134 155257..156018 1 NC_010677.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 156018 tpiA 6291134 tpiA Francisella tularensis subsp. mediasiatica FSC147 triosephosphate isomerase YP_001891020.1 155257 D 441952 CDS YP_001891021.1 187931037 6290834 156006..156359 1 NC_010677.1 preprotein translocase subunit SecG 156359 secG 6290834 secG Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecG YP_001891021.1 156006 D 441952 CDS YP_001891022.1 187931038 6291398 complement(158036..159178) 1 NC_010677.1 coproporphyrinogen III oxidase, anaerobic 159178 hemN 6291398 hemN Francisella tularensis subsp. mediasiatica FSC147 coproporphyrinogen III oxidase, anaerobic YP_001891022.1 158036 R 441952 CDS YP_001891023.1 187931039 6290576 complement(159183..159560) 1 NC_010677.1 GtrA-like protein 159560 6290576 FTM_0150 Francisella tularensis subsp. mediasiatica FSC147 GtrA-like protein YP_001891023.1 159183 R 441952 CDS YP_001891024.1 187931040 6290664 159630..160508 1 NC_010677.1 iron-dependent peroxidase 160508 6290664 FTM_0151 Francisella tularensis subsp. mediasiatica FSC147 iron-dependent peroxidase YP_001891024.1 159630 D 441952 CDS YP_001891025.1 187931041 6290445 160613..163426 1 NC_010677.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 163426 acnA 6290445 acnA Francisella tularensis subsp. mediasiatica FSC147 aconitate hydratase YP_001891025.1 160613 D 441952 CDS YP_001891026.1 187931042 6290783 complement(166432..166878) 1 NC_010677.1 hypothetical protein 166878 6290783 FTM_0155 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891026.1 166432 R 441952 CDS YP_001891027.1 187931043 6290702 169467..170348 1 NC_010677.1 NAD dependent epimerase/dehydratase family 170348 6290702 FTM_0158 Francisella tularensis subsp. mediasiatica FSC147 NAD dependent epimerase/dehydratase family YP_001891027.1 169467 D 441952 CDS YP_001891028.1 187931044 6290069 complement(170345..171772) 1 NC_010677.1 two-component regulator, sensor histidine kinase 171772 6290069 FTM_0159 Francisella tularensis subsp. mediasiatica FSC147 two-component regulator, sensor histidine kinase YP_001891028.1 170345 R 441952 CDS YP_001891029.1 187931045 6290310 174285..174806 1 NC_010677.1 hypothetical protein 174806 6290310 FTM_0162 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891029.1 174285 D 441952 CDS YP_001891030.1 187931046 6290573 177103..178116 1 NC_010677.1 peptidase, U61 family 178116 6290573 FTM_0164 Francisella tularensis subsp. mediasiatica FSC147 peptidase, U61 family YP_001891030.1 177103 D 441952 CDS YP_001891031.1 187931047 6290495 complement(179561..180142) 1 NC_010677.1 transposase, IS4 family protein 180142 6290495 FTM_0165 Francisella tularensis subsp. mediasiatica FSC147 transposase, IS4 family protein YP_001891031.1 179561 R 441952 CDS YP_001891032.1 187931048 6290396 complement(180384..181664) 1 NC_010677.1 major facilitator superfamily protein 181664 6290396 FTM_0166 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily protein YP_001891032.1 180384 R 441952 CDS YP_001891033.1 187931049 6290987 complement(181784..184897) 1 NC_010677.1 transporter, AcrB/AcrD/AcrF family 184897 6290987 FTM_0167 Francisella tularensis subsp. mediasiatica FSC147 transporter, AcrB/AcrD/AcrF family YP_001891033.1 181784 R 441952 CDS YP_001891034.1 187931050 6291436 complement(184897..186270) 1 NC_010677.1 membrane fusion protein 186270 6291436 FTM_0168 Francisella tularensis subsp. mediasiatica FSC147 membrane fusion protein YP_001891034.1 184897 R 441952 CDS YP_001891035.1 187931051 6290255 complement(186283..186774) 1 NC_010677.1 disulfide bond formation protein 186774 dsbB 6290255 dsbB Francisella tularensis subsp. mediasiatica FSC147 disulfide bond formation protein YP_001891035.1 186283 R 441952 CDS YP_001891036.1 187931052 6291168 complement(186814..187896) 1 NC_010677.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 187896 cca 6291168 cca Francisella tularensis subsp. mediasiatica FSC147 tRNA CCA-pyrophosphorylase YP_001891036.1 186814 R 441952 CDS YP_001891037.1 187931053 6290571 188001..189830 1 NC_010677.1 lipid A export permease/ATP-binding protein MsbA 189830 msbA 6290571 msbA Francisella tularensis subsp. mediasiatica FSC147 lipid A export permease/ATP-binding protein MsbA YP_001891037.1 188001 D 441952 CDS YP_001891038.1 187931054 6291251 189836..190804 1 NC_010677.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 190804 lpxK 6291251 lpxK Francisella tularensis subsp. mediasiatica FSC147 tetraacyldisaccharide 4'-kinase YP_001891038.1 189836 D 441952 CDS YP_001891039.1 187931055 6290271 190900..193593 1 NC_010677.1 DNA polymerase I 193593 polA 6290271 polA Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase I YP_001891039.1 190900 D 441952 CDS YP_001891040.1 187931056 6291256 193613..194389 1 NC_010677.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 194389 6291256 FTM_0174 Francisella tularensis subsp. mediasiatica FSC147 pantothenate kinase YP_001891040.1 193613 D 441952 CDS YP_001891041.1 187931057 6291514 194394..195638 1 NC_010677.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 195638 deoB 6291514 deoB Francisella tularensis subsp. mediasiatica FSC147 phosphopentomutase YP_001891041.1 194394 D 441952 CDS YP_001891042.1 187931058 6290640 195601..196362 1 NC_010677.1 deoxyribose-phosphate aldolase 196362 deoC 6290640 deoC Francisella tularensis subsp. mediasiatica FSC147 deoxyribose-phosphate aldolase YP_001891042.1 195601 D 441952 CDS YP_001891043.1 187931059 6291281 196352..197551 1 NC_010677.1 nucleoside permease NupC 197551 nupC1 6291281 nupC1 Francisella tularensis subsp. mediasiatica FSC147 nucleoside permease NupC YP_001891043.1 196352 D 441952 CDS YP_001891044.1 187931060 6290393 197570..198772 1 NC_010677.1 nucleoside permease NupC 198772 nupC 6290393 nupC Francisella tularensis subsp. mediasiatica FSC147 nucleoside permease NupC YP_001891044.1 197570 D 441952 CDS YP_001891045.1 187931061 6291568 198785..199414 1 NC_010677.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 199414 tmk 6291568 tmk Francisella tularensis subsp. mediasiatica FSC147 thymidylate kinase YP_001891045.1 198785 D 441952 CDS YP_001891046.1 187931062 6290759 199476..201053 1 NC_010677.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 201053 prfC 6290759 prfC Francisella tularensis subsp. mediasiatica FSC147 peptide chain release factor 3 YP_001891046.1 199476 D 441952 CDS YP_001891047.1 187931063 6290373 201128..202447 1 NC_010677.1 type IV pili, pilus assembly protein 202447 fimV 6290373 fimV Francisella tularensis subsp. mediasiatica FSC147 type IV pili, pilus assembly protein YP_001891047.1 201128 D 441952 CDS YP_001891048.1 187931064 6291352 202480..203475 1 NC_010677.1 signal recognition particle-docking protein FtsY 203475 ftsY 6291352 ftsY Francisella tularensis subsp. mediasiatica FSC147 signal recognition particle-docking protein FtsY YP_001891048.1 202480 D 441952 CDS YP_001891049.1 187931065 6290848 203566..205788 1 NC_010677.1 DNA helicase II 205788 uvrD 6290848 uvrD Francisella tularensis subsp. mediasiatica FSC147 DNA helicase II YP_001891049.1 203566 D 441952 CDS YP_001891050.1 187931066 6290454 205907..207475 1 NC_010677.1 oligopeptide ABC transporter periplasmic protein 207475 6290454 FTM_0184 Francisella tularensis subsp. mediasiatica FSC147 oligopeptide ABC transporter periplasmic protein YP_001891050.1 205907 D 441952 CDS YP_001891051.1 187931067 6291498 209380..210348 1 NC_010677.1 peptide/opine/nickel uptake transporter (PepT) family protein 210348 oppD 6291498 oppD Francisella tularensis subsp. mediasiatica FSC147 peptide/opine/nickel uptake transporter (PepT) family protein YP_001891051.1 209380 D 441952 CDS YP_001891052.1 187931068 6291086 complement(211326..212528) 1 NC_010677.1 major facilitator superfamily protein 212528 6291086 FTM_0189 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily protein YP_001891052.1 211326 R 441952 CDS YP_001891053.1 187931069 6291014 212662..213243 1 NC_010677.1 hypothetical protein 213243 6291014 FTM_0190 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891053.1 212662 D 441952 CDS YP_001891054.1 187931070 6290753 213342..214655 1 NC_010677.1 sugar transporter, MFS superfamily 214655 6290753 FTM_0191 Francisella tularensis subsp. mediasiatica FSC147 sugar transporter, MFS superfamily YP_001891054.1 213342 D 441952 CDS YP_001891055.1 187931071 6291474 214712..216220 1 NC_010677.1 glycerol kinase 216220 glpK 6291474 glpK Francisella tularensis subsp. mediasiatica FSC147 glycerol kinase YP_001891055.1 214712 D 441952 CDS YP_001891056.1 187931072 6291416 217283..218815 1 NC_010677.1 glycerol-3-phosphate dehydrogenase 218815 glpD 6291416 glpD Francisella tularensis subsp. mediasiatica FSC147 glycerol-3-phosphate dehydrogenase YP_001891056.1 217283 D 441952 CDS YP_001891057.1 187931073 6290723 218825..219589 1 NC_010677.1 glycerol uptake facilitator protein 219589 glpF 6290723 glpF Francisella tularensis subsp. mediasiatica FSC147 glycerol uptake facilitator protein YP_001891057.1 218825 D 441952 CDS YP_001891058.1 187931074 6291706 219593..220306 1 NC_010677.1 membrane protein 220306 6291706 FTM_0195 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891058.1 219593 D 441952 CDS YP_001891059.1 187931075 6291611 220284..220781 1 NC_010677.1 small conductance mechanosensitive ion channel (MscS) family protein 220781 6291611 FTM_0196 Francisella tularensis subsp. mediasiatica FSC147 small conductance mechanosensitive ion channel (MscS) family protein YP_001891059.1 220284 D 441952 CDS YP_001891060.1 187931076 6290303 222659..223843 1 NC_010677.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 223843 tufA 6290303 tufA Francisella tularensis subsp. mediasiatica FSC147 elongation factor Tu YP_001891060.1 222659 D 441952 CDS YP_001891061.1 187931077 6290966 224036..224506 1 NC_010677.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 224506 secE 6290966 secE Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecE YP_001891061.1 224036 D 441952 CDS YP_001891062.1 187931078 6291087 224522..225055 1 NC_010677.1 transcription termination/antitermination factor NusG 225055 nusG 6291087 nusG Francisella tularensis subsp. mediasiatica FSC147 transcription termination/antitermination factor NusG YP_001891062.1 224522 D 441952 CDS YP_001891063.1 187931079 6290334 225125..225559 1 NC_010677.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 225559 rplK 6290334 rplK Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L11 YP_001891063.1 225125 D 441952 CDS YP_001891064.1 187931080 6290762 225562..226257 1 NC_010677.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 226257 rplA 6290762 rplA Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L1 YP_001891064.1 225562 D 441952 CDS YP_001891065.1 187931081 6291613 226427..226945 1 NC_010677.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 226945 rplJ 6291613 rplJ Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L10 YP_001891065.1 226427 D 441952 CDS YP_001891066.1 187931082 6291579 227008..227388 1 NC_010677.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 227388 rplL 6291579 rplL Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L7/L12 YP_001891066.1 227008 D 441952 CDS YP_001891067.1 187931083 6291615 227542..231618 1 NC_010677.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 231618 rpoB 6291615 rpoB Francisella tularensis subsp. mediasiatica FSC147 DNA-directed RNA polymerase subunit beta YP_001891067.1 227542 D 441952 CDS YP_001891068.1 187931084 6290545 231680..235933 1 NC_010677.1 DNA-directed RNA polymerase subunit beta' 235933 rpoC 6290545 rpoC Francisella tularensis subsp. mediasiatica FSC147 DNA-directed RNA polymerase subunit beta' YP_001891068.1 231680 D 441952 CDS YP_001891069.1 187931085 6290821 236036..236272 1 NC_010677.1 membrane protein 236272 6290821 FTM_0211 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891069.1 236036 D 441952 CDS YP_001891070.1 187931086 6290867 236272..237282 1 NC_010677.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 237282 gcp 6290867 gcp Francisella tularensis subsp. mediasiatica FSC147 putative DNA-binding/iron metalloprotein/AP endonuclease YP_001891070.1 236272 D 441952 CDS YP_001891071.1 187931087 6290222 237396..238562 1 NC_010677.1 fatty acid desaturase 238562 6290222 FTM_0213 Francisella tularensis subsp. mediasiatica FSC147 fatty acid desaturase YP_001891071.1 237396 D 441952 CDS YP_001891072.1 187931088 6290868 complement(238774..239934) 1 NC_010677.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 239934 metK 6290868 metK Francisella tularensis subsp. mediasiatica FSC147 S-adenosylmethionine synthetase YP_001891072.1 238774 R 441952 CDS YP_001891073.1 187931089 6291210 240228..240476 1 NC_010677.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 240476 rpsP 6291210 rpsP Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S16 YP_001891073.1 240228 D 441952 CDS YP_001891074.1 187931090 6291374 240519..241028 1 NC_010677.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 241028 rimM 6291374 rimM Francisella tularensis subsp. mediasiatica FSC147 16S rRNA-processing protein RimM YP_001891074.1 240519 D 441952 CDS YP_001891075.1 187931091 6290685 241431..242189 1 NC_010677.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 242189 trmD 6290685 trmD Francisella tularensis subsp. mediasiatica FSC147 tRNA (guanine-N(1)-)-methyltransferase YP_001891075.1 241431 D 441952 CDS YP_001891076.1 187931092 6290213 242189..242536 1 NC_010677.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 242536 rplS 6290213 rplS Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L19 YP_001891076.1 242189 D 441952 CDS YP_001891077.1 187931093 6291390 242702..243580 1 NC_010677.1 tyrosine recombinase XerD 243580 xerD 6291390 xerD Francisella tularensis subsp. mediasiatica FSC147 tyrosine recombinase XerD YP_001891077.1 242702 D 441952 CDS YP_001891078.1 187931094 6291149 244554..245138 1 NC_010677.1 acid phosphatase, HAD superfamily protein 245138 6291149 FTM_0221 Francisella tularensis subsp. mediasiatica FSC147 acid phosphatase, HAD superfamily protein YP_001891078.1 244554 D 441952 CDS YP_001891079.1 187931095 6290935 247820..248287 1 NC_010677.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 248287 6290935 FTM_0224 Francisella tularensis subsp. mediasiatica FSC147 dinucleoside polyphosphate hydrolase YP_001891079.1 247820 D 441952 CDS YP_001891080.1 187931096 6290300 complement(248297..248923) 1 NC_010677.1 dGTP pyrophosphohydrolase 248923 nudH 6290300 nudH Francisella tularensis subsp. mediasiatica FSC147 dGTP pyrophosphohydrolase YP_001891080.1 248297 R 441952 CDS YP_001891081.1 187931097 6291559 248997..249521 1 NC_010677.1 N-acetyl-anhydromuranmyl-L-alanine amidase 249521 ampD 6291559 ampD Francisella tularensis subsp. mediasiatica FSC147 N-acetyl-anhydromuranmyl-L-alanine amidase YP_001891081.1 248997 D 441952 CDS YP_001891082.1 187931098 6290461 complement(249569..251452) 1 NC_010677.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 251452 parE 6290461 parE Francisella tularensis subsp. mediasiatica FSC147 DNA topoisomerase IV subunit B YP_001891082.1 249569 R 441952 CDS YP_001891083.1 187931099 6290277 complement(251543..252724) 1 NC_010677.1 drug:H+ antiporter-1 (DHA1) family protein 252724 6290277 FTM_0228 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 (DHA1) family protein YP_001891083.1 251543 R 441952 CDS YP_001891084.1 187931100 6290649 complement(252724..254094) 1 NC_010677.1 outer membrane assembly lipoprotein YfgL 254094 6290649 FTM_0229 Francisella tularensis subsp. mediasiatica FSC147 outer membrane assembly lipoprotein YfgL YP_001891084.1 252724 R 441952 CDS YP_001891085.1 187931101 6291315 complement(254097..254735) 1 NC_010677.1 hypothetical protein 254735 6291315 FTM_0230 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891085.1 254097 R 441952 CDS YP_001891086.1 187931102 6290352 254915..256159 1 NC_010677.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 256159 hemA 6290352 hemA Francisella tularensis subsp. mediasiatica FSC147 glutamyl-tRNA reductase YP_001891086.1 254915 D 441952 CDS YP_001891087.1 187931103 6290270 256160..257245 1 NC_010677.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 257245 prfA 6290270 prfA Francisella tularensis subsp. mediasiatica FSC147 peptide chain release factor 1 YP_001891087.1 256160 D 441952 CDS YP_001891088.1 187931104 6290811 257238..258092 1 NC_010677.1 HemK family modification methylase 258092 hemK 6290811 hemK Francisella tularensis subsp. mediasiatica FSC147 HemK family modification methylase YP_001891088.1 257238 D 441952 CDS YP_001891089.1 187931105 6290555 complement(259511..261145) 1 NC_010677.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 261145 groEL 6290555 groEL Francisella tularensis subsp. mediasiatica FSC147 chaperonin GroEL YP_001891089.1 259511 R 441952 CDS YP_001891090.1 187931106 6291636 complement(261183..261470) 1 NC_010677.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 261470 groES 6291636 groES Francisella tularensis subsp. mediasiatica FSC147 co-chaperonin GroES YP_001891090.1 261183 R 441952 CDS YP_001891091.1 187931107 6291486 261720..262154 1 NC_010677.1 hypothetical protein 262154 6291486 FTM_0237 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891091.1 261720 D 441952 CDS YP_001891092.1 187931108 6290337 262795..263559 1 NC_010677.1 hypothetical protein 263559 6290337 FTM_0239 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891092.1 262795 D 441952 CDS YP_001891093.1 187931109 6291100 266052..266753 1 NC_010677.1 activator of osmoprotectant transporter ProP 266753 proQ 6291100 proQ Francisella tularensis subsp. mediasiatica FSC147 activator of osmoprotectant transporter ProP YP_001891093.1 266052 D 441952 CDS YP_001891094.1 187931110 6290264 266776..267321 1 NC_010677.1 hypothetical protein 267321 6290264 FTM_0244 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891094.1 266776 D 441952 CDS YP_001891095.1 187931111 6291072 complement(267336..268790) 1 NC_010677.1 K+ transporter (Trk) family protein 268790 trkH 6291072 trkH Francisella tularensis subsp. mediasiatica FSC147 K+ transporter (Trk) family protein YP_001891095.1 267336 R 441952 CDS YP_001891096.1 187931112 6291468 268902..269105 1 NC_010677.1 hypothetical protein 269105 6291468 FTM_0246 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891096.1 268902 D 441952 CDS YP_001891097.1 187931113 6291424 complement(269487..270104) 1 NC_010677.1 lipoprotein releasing system, subunit A, outer membrane lipoproteins carrier 270104 lolA 6291424 lolA Francisella tularensis subsp. mediasiatica FSC147 lipoprotein releasing system, subunit A, outer membrane lipoproteins carrier YP_001891097.1 269487 R 441952 CDS YP_001891098.1 187931114 6291592 complement(270105..272600) 1 NC_010677.1 cell division protein FtsK 272600 ftsK 6291592 ftsK Francisella tularensis subsp. mediasiatica FSC147 cell division protein FtsK YP_001891098.1 270105 R 441952 CDS YP_001891099.1 187931115 6290988 272722..273390 1 NC_010677.1 phosphatidic acid phosphatase, PAP2 superfamily 273390 6290988 FTM_0249 Francisella tularensis subsp. mediasiatica FSC147 phosphatidic acid phosphatase, PAP2 superfamily YP_001891099.1 272722 D 441952 CDS YP_001891100.1 187931116 6291632 273637..275091 1 NC_010677.1 lysine:H+ symporter 275091 lysP 6291632 lysP Francisella tularensis subsp. mediasiatica FSC147 lysine:H+ symporter YP_001891100.1 273637 D 441952 CDS YP_001891101.1 187931117 6291581 275100..275738 1 NC_010677.1 hypothetical protein 275738 6291581 FTM_0251 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891101.1 275100 D 441952 CDS YP_001891102.1 187931118 6291267 275758..276744 1 NC_010677.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 276744 glpX 6291267 glpX Francisella tularensis subsp. mediasiatica FSC147 fructose 1,6-bisphosphatase II YP_001891102.1 275758 D 441952 CDS YP_001891103.1 187931119 6290758 278587..280266 1 NC_010677.1 glycosyl transferase 280266 6290758 FTM_0254 Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase YP_001891103.1 278587 D 441952 CDS YP_001891104.1 187931120 6291618 280277..281584 1 NC_010677.1 transporter-associated protein, HlyC/CorC family 281584 6291618 FTM_0255 Francisella tularensis subsp. mediasiatica FSC147 transporter-associated protein, HlyC/CorC family YP_001891104.1 280277 D 441952 CDS YP_001891105.1 187931121 6291321 281655..282002 1 NC_010677.1 hypothetical protein 282002 6291321 FTM_0256 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891105.1 281655 D 441952 CDS YP_001891106.1 187931122 6291458 284318..284938 1 NC_010677.1 pilus assembly protein 284938 6291458 FTM_0259 Francisella tularensis subsp. mediasiatica FSC147 pilus assembly protein YP_001891106.1 284318 D 441952 CDS YP_001891107.1 187931123 6291399 complement(288762..289253) 1 NC_010677.1 acetyltransferase 289253 6291399 FTM_0263 Francisella tularensis subsp. mediasiatica FSC147 acetyltransferase YP_001891107.1 288762 R 441952 CDS YP_001891108.1 187931124 6290844 complement(289279..290457) 1 NC_010677.1 drug:H+ antiporter-1 290457 6290844 FTM_0264 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 YP_001891108.1 289279 R 441952 CDS YP_001891109.1 187931125 6290379 complement(290513..291457) 1 NC_010677.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 291457 6290379 FTM_0265 Francisella tularensis subsp. mediasiatica FSC147 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_001891109.1 290513 R 441952 CDS YP_001891110.1 187931126 6291324 complement(291461..292840) 1 NC_010677.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 292840 cysS 6291324 cysS Francisella tularensis subsp. mediasiatica FSC147 cysteinyl-tRNA synthetase YP_001891110.1 291461 R 441952 CDS YP_001891111.1 187931127 6291178 complement(294289..294570) 1 NC_010677.1 membrane protein 294570 6291178 FTM_0269 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891111.1 294289 R 441952 CDS YP_001891112.1 187931128 6291249 complement(294583..296085) 1 NC_010677.1 amino acid-polyamine-organocation family protein 296085 6291249 FTM_0270 Francisella tularensis subsp. mediasiatica FSC147 amino acid-polyamine-organocation family protein YP_001891112.1 294583 R 441952 CDS YP_001891113.1 187931129 6290239 complement(296450..297193) 1 NC_010677.1 hypothetical protein 297193 6290239 FTM_0271 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891113.1 296450 R 441952 CDS YP_001891114.1 187931130 6291037 complement(297195..297890) 1 NC_010677.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 297890 ubiG 6291037 ubiG Francisella tularensis subsp. mediasiatica FSC147 3-demethylubiquinone-9 3-methyltransferase YP_001891114.1 297195 R 441952 CDS YP_001891115.1 187931131 6290378 298032..299132 1 NC_010677.1 VacJ family protein 299132 6290378 FTM_0273 Francisella tularensis subsp. mediasiatica FSC147 VacJ family protein YP_001891115.1 298032 D 441952 CDS YP_001891116.1 187931132 6291141 304236..304961 1 NC_010677.1 hypothetical protein 304961 6291141 FTM_0277 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891116.1 304236 D 441952 CDS YP_001891117.1 187931133 6291183 311395..311865 1 NC_010677.1 hypothetical protein 311865 6291183 FTM_0281 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891117.1 311395 D 441952 CDS YP_001891118.1 187931134 6290625 312002..312826 1 NC_010677.1 short-chain dehydrogenase/reductase 312826 6290625 FTM_0282 Francisella tularensis subsp. mediasiatica FSC147 short-chain dehydrogenase/reductase YP_001891118.1 312002 D 441952 CDS YP_001891119.1 187931135 6290705 complement(312848..314197) 1 NC_010677.1 amino acid-polyamine-organocation (APC) superfamily protein 314197 6290705 FTM_0283 Francisella tularensis subsp. mediasiatica FSC147 amino acid-polyamine-organocation (APC) superfamily protein YP_001891119.1 312848 R 441952 CDS YP_001891120.1 187931136 6291604 complement(314456..315328) 1 NC_010677.1 hypothetical protein 315328 6291604 FTM_0284 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891120.1 314456 R 441952 CDS YP_001891121.1 187931137 6291160 complement(316274..316723) 1 NC_010677.1 hypothetical protein 316723 6291160 FTM_0285 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891121.1 316274 R 441952 CDS YP_001891122.1 187931138 6291235 complement(316732..317127) 1 NC_010677.1 hypothetical protein 317127 6291235 FTM_0286 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891122.1 316732 R 441952 CDS YP_001891123.1 187931139 6291464 317210..317941 1 NC_010677.1 oxidoreductase 317941 6291464 FTM_0287 Francisella tularensis subsp. mediasiatica FSC147 oxidoreductase YP_001891123.1 317210 D 441952 CDS YP_001891124.1 187931140 6290323 318063..318278 1 NC_010677.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 318278 rpmE 6290323 rpmE Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L31 YP_001891124.1 318063 D 441952 CDS YP_001891125.1 187931141 6290212 complement(318489..319994) 1 NC_010677.1 glutamate-cysteine ligase 319994 gshA 6290212 gshA Francisella tularensis subsp. mediasiatica FSC147 glutamate-cysteine ligase YP_001891125.1 318489 R 441952 CDS YP_001891126.1 187931142 6290838 complement(320047..321588) 1 NC_010677.1 multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) transporter 321588 mviN 6290838 mviN Francisella tularensis subsp. mediasiatica FSC147 multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) transporter YP_001891126.1 320047 R 441952 CDS YP_001891127.1 187931143 6290913 complement(321611..322672) 1 NC_010677.1 hypothetical protein 322672 6290913 FTM_0291 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891127.1 321611 R 441952 CDS YP_001891128.1 187931144 6291492 complement(322755..323165) 1 NC_010677.1 hypothetical protein 323165 6291492 FTM_0292 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891128.1 322755 R 441952 CDS YP_001891129.1 187931145 6291167 complement(323143..324324) 1 NC_010677.1 folylpoly-gamma-glutamate synthetase/ dihydrofolate synthetase 324324 folC 6291167 folC Francisella tularensis subsp. mediasiatica FSC147 folylpoly-gamma-glutamate synthetase/ dihydrofolate synthetase YP_001891129.1 323143 R 441952 CDS YP_001891130.1 187931146 6291022 complement(324339..325241) 1 NC_010677.1 acetyl-CoA carboxylase, carboxyl transferase subunit beta 325241 accD 6291022 accD Francisella tularensis subsp. mediasiatica FSC147 acetyl-CoA carboxylase, carboxyl transferase subunit beta YP_001891130.1 324339 R 441952 CDS YP_001891131.1 187931147 6290365 complement(325283..325705) 1 NC_010677.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 325705 ndk 6290365 ndk Francisella tularensis subsp. mediasiatica FSC147 nucleoside diphosphate kinase YP_001891131.1 325283 R 441952 CDS YP_001891132.1 187931148 6290575 complement(325778..327418) 1 NC_010677.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 327418 pyrG 6290575 pyrG Francisella tularensis subsp. mediasiatica FSC147 CTP synthetase YP_001891132.1 325778 R 441952 CDS YP_001891133.1 187931149 6290816 complement(329475..330431) 1 NC_010677.1 membrane protein 330431 6290816 FTM_0298 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891133.1 329475 R 441952 CDS YP_001891134.1 187931150 6291499 332556..333521 1 NC_010677.1 glycosyltransferase sugar-binding region containing DXD motif family 333521 6291499 FTM_0299 Francisella tularensis subsp. mediasiatica FSC147 glycosyltransferase sugar-binding region containing DXD motif family YP_001891134.1 332556 D 441952 CDS YP_001891135.1 187931151 6290281 334630..336516 1 NC_010677.1 molecular chaperone; heat shock protein 90 336516 htpG 6290281 htpG Francisella tularensis subsp. mediasiatica FSC147 heat shock protein 90 YP_001891135.1 334630 D 441952 CDS YP_001891136.1 187931152 6290444 complement(337979..339493) 1 NC_010677.1 fumarate hydratase, class I 339493 fumA 6290444 fumA Francisella tularensis subsp. mediasiatica FSC147 fumarate hydratase, class I YP_001891136.1 337979 R 441952 CDS YP_001891137.1 187931153 6291154 complement(340045..340242) 1 NC_010677.1 hypothetical protein 340242 6291154 FTM_0302 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891137.1 340045 R 441952 CDS YP_001891138.1 187931154 6291649 complement(340246..342285) 1 NC_010677.1 ATP-dependent DNA helicase RecG 342285 recG 6291649 recG Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent DNA helicase RecG YP_001891138.1 340246 R 441952 CDS YP_001891139.1 187931155 6290862 342415..342759 1 NC_010677.1 hypothetical protein 342759 6290862 FTM_0304 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891139.1 342415 D 441952 CDS YP_001891140.1 187931156 6291215 342894..343130 1 NC_010677.1 required for 70S ribosome assembly; 50S ribosomal protein L28 343130 rpmB 6291215 rpmB Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L28 YP_001891140.1 342894 D 441952 CDS YP_001891141.1 187931157 6291537 343157..343312 1 NC_010677.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 343312 rpmG 6291537 rpmG Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L33 YP_001891141.1 343157 D 441952 CDS YP_001891142.1 187931158 6291005 343347..344033 1 NC_010677.1 septum formation inhibitor 344033 minC 6291005 minC Francisella tularensis subsp. mediasiatica FSC147 septum formation inhibitor YP_001891142.1 343347 D 441952 CDS YP_001891143.1 187931159 6290250 344073..344897 1 NC_010677.1 septum formation inhibitor-activating ATPase 344897 minD 6290250 minD Francisella tularensis subsp. mediasiatica FSC147 septum formation inhibitor-activating ATPase YP_001891143.1 344073 D 441952 CDS YP_001891144.1 187931160 6290768 344900..345172 1 NC_010677.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 345172 minE 6290768 minE Francisella tularensis subsp. mediasiatica FSC147 cell division topological specificity factor MinE YP_001891144.1 344900 D 441952 CDS YP_001891145.1 187931161 6291312 345186..345989 1 NC_010677.1 ABC transporter ATP-binding protein 345989 6291312 FTM_0310 Francisella tularensis subsp. mediasiatica FSC147 ABC transporter ATP-binding protein YP_001891145.1 345186 D 441952 CDS YP_001891146.1 187931162 6291577 345993..346757 1 NC_010677.1 ABC-type transport system permease protein 346757 6291577 FTM_0311 Francisella tularensis subsp. mediasiatica FSC147 ABC-type transport system permease protein YP_001891146.1 345993 D 441952 CDS YP_001891147.1 187931163 6290922 346757..347290 1 NC_010677.1 ABC transporter substrate-binding protein 347290 6290922 FTM_0312 Francisella tularensis subsp. mediasiatica FSC147 ABC transporter substrate-binding protein YP_001891147.1 346757 D 441952 CDS YP_001891148.1 187931164 6291331 347364..348026 1 NC_010677.1 hypothetical protein 348026 6291331 FTM_0313 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891148.1 347364 D 441952 CDS YP_001891149.1 187931165 6291371 348026..348319 1 NC_010677.1 hypothetical protein 348319 6291371 FTM_0314 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891149.1 348026 D 441952 CDS YP_001891150.1 187931166 6291419 348336..348572 1 NC_010677.1 BolA family protein 348572 6291419 FTM_0315 Francisella tularensis subsp. mediasiatica FSC147 BolA family protein YP_001891150.1 348336 D 441952 CDS YP_001891151.1 187931167 6290840 353138..353638 1 NC_010677.1 hypothetical protein 353638 6290840 FTM_0319 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891151.1 353138 D 441952 CDS YP_001891152.1 187931168 6291516 353839..356565 1 NC_010677.1 type III restriction enzyme 356565 6291516 FTM_0320 Francisella tularensis subsp. mediasiatica FSC147 type III restriction enzyme YP_001891152.1 353839 D 441952 CDS YP_001891153.1 187931169 6291028 356562..357224 1 NC_010677.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 357224 ung 6291028 ung Francisella tularensis subsp. mediasiatica FSC147 uracil-DNA glycosylase YP_001891153.1 356562 D 441952 CDS YP_001891154.1 187931170 6291067 359184..361790 1 NC_010677.1 DNA gyrase subunit A 361790 gyrA 6291067 gyrA Francisella tularensis subsp. mediasiatica FSC147 DNA gyrase subunit A YP_001891154.1 359184 D 441952 CDS YP_001891155.1 187931171 6290418 361796..362953 1 NC_010677.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 362953 dxr 6290418 dxr Francisella tularensis subsp. mediasiatica FSC147 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001891155.1 361796 D 441952 CDS YP_001891156.1 187931172 6290543 362959..365337 1 NC_010677.1 hypothetical protein 365337 6290543 FTM_0325 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891156.1 362959 D 441952 CDS YP_001891157.1 187931173 6290879 365473..365976 1 NC_010677.1 outer membrane protein OmpH 365976 ompH 6290879 ompH Francisella tularensis subsp. mediasiatica FSC147 outer membrane protein OmpH YP_001891157.1 365473 D 441952 CDS YP_001891158.1 187931174 6291542 365995..367008 1 NC_010677.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 367008 lpxD 6291542 lpxD Francisella tularensis subsp. mediasiatica FSC147 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001891158.1 365995 D 441952 CDS YP_001891159.1 187931175 6291157 367023..367514 1 NC_010677.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 367514 fabZ 6291157 fabZ Francisella tularensis subsp. mediasiatica FSC147 (3R)-hydroxymyristoyl-ACP dehydratase YP_001891159.1 367023 D 441952 CDS YP_001891160.1 187931176 6290678 367517..368296 1 NC_010677.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 368296 lpxA 6290678 lpxA Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylglucosamine acyltransferase YP_001891160.1 367517 D 441952 CDS YP_001891161.1 187931177 6290459 368296..369438 1 NC_010677.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 369438 lpxB 6290459 lpxB Francisella tularensis subsp. mediasiatica FSC147 lipid-A-disaccharide synthase YP_001891161.1 368296 D 441952 CDS YP_001891162.1 187931178 6291633 369497..370084 1 NC_010677.1 membrane protein 370084 6291633 FTM_0331 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891162.1 369497 D 441952 CDS YP_001891163.1 187931179 6291225 370175..370549 1 NC_010677.1 hypothetical protein 370549 6291225 FTM_0332 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891163.1 370175 D 441952 CDS YP_001891164.1 187931180 6291430 complement(372346..373155) 1 NC_010677.1 polyphosphate kinase 2 373155 6291430 FTM_0335 Francisella tularensis subsp. mediasiatica FSC147 polyphosphate kinase 2 YP_001891164.1 372346 R 441952 CDS YP_001891165.1 187931181 6290713 complement(373225..373989) 1 NC_010677.1 (CDP-alcohol) phosphatidyltransferase 373989 pcs 6290713 pcs Francisella tularensis subsp. mediasiatica FSC147 (CDP-alcohol) phosphatidyltransferase YP_001891165.1 373225 R 441952 CDS YP_001891166.1 187931182 6290742 complement(374037..374918) 1 NC_010677.1 geranyl diphosphate synthase/farnesyl diphosphate synthase 374918 ispA 6290742 ispA Francisella tularensis subsp. mediasiatica FSC147 geranyl diphosphate synthase/farnesyl diphosphate synthase YP_001891166.1 374037 R 441952 CDS YP_001891167.1 187931183 6290819 complement(374915..376210) 1 NC_010677.1 3-deoxy-D-manno-octulosonic-acid transferase 376210 kdtA 6290819 kdtA Francisella tularensis subsp. mediasiatica FSC147 3-deoxy-D-manno-octulosonic-acid transferase YP_001891167.1 374915 R 441952 CDS YP_001891168.1 187931184 6291201 complement(376315..376893) 1 NC_010677.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 376893 6291201 FTM_0339 Francisella tularensis subsp. mediasiatica FSC147 putative deoxyribonucleotide triphosphate pyrophosphatase YP_001891168.1 376315 R 441952 CDS YP_001891169.1 187931185 6290374 377000..377797 1 NC_010677.1 pyrroline-5-carboxylate reductase 377797 proC 6290374 proC Francisella tularensis subsp. mediasiatica FSC147 pyrroline-5-carboxylate reductase YP_001891169.1 377000 D 441952 CDS YP_001891170.1 187931186 6290565 379560..380246 1 NC_010677.1 two-component response regulator 380246 6290565 FTM_0342 Francisella tularensis subsp. mediasiatica FSC147 two-component response regulator YP_001891170.1 379560 D 441952 CDS YP_001891171.1 187931187 6291325 380251..381114 1 NC_010677.1 signal peptidase I 381114 lepB 6291325 lepB Francisella tularensis subsp. mediasiatica FSC147 signal peptidase I YP_001891171.1 380251 D 441952 CDS YP_001891172.1 187931188 6290804 381121..381813 1 NC_010677.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 381813 rnc 6290804 rnc Francisella tularensis subsp. mediasiatica FSC147 ribonuclease III YP_001891172.1 381121 D 441952 CDS YP_001891173.1 187931189 6291500 381800..382708 1 NC_010677.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 382708 truB 6291500 truB Francisella tularensis subsp. mediasiatica FSC147 tRNA pseudouridine synthase B YP_001891173.1 381800 D 441952 CDS YP_001891174.1 187931190 6290598 382701..384998 1 NC_010677.1 ribonuclease R 384998 rnr 6290598 rnr Francisella tularensis subsp. mediasiatica FSC147 ribonuclease R YP_001891174.1 382701 D 441952 CDS YP_001891175.1 187931191 6290752 complement(385455..386198) 1 NC_010677.1 oxidoreductase 386198 6290752 FTM_0348 Francisella tularensis subsp. mediasiatica FSC147 oxidoreductase YP_001891175.1 385455 R 441952 CDS YP_001891176.1 187931192 6290769 complement(386781..387254) 1 NC_010677.1 frameshift compared to novicida makes this ORF 15 aa shorter; hypothetical protein 387254 6290769 FTM_0350 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891176.1 386781 R 441952 CDS YP_001891177.1 187931193 6290450 complement(392469..393158) 1 NC_010677.1 two component response regulator 393158 6290450 FTM_0355 Francisella tularensis subsp. mediasiatica FSC147 two component response regulator YP_001891177.1 392469 R 441952 CDS YP_001891178.1 187931194 6290941 393301..393840 1 NC_010677.1 membrane protein 393840 6290941 FTM_0356 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891178.1 393301 D 441952 CDS YP_001891179.1 187931195 6290403 393958..394359 1 NC_010677.1 membrane protein 394359 6290403 FTM_0357 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891179.1 393958 D 441952 CDS YP_001891180.1 187931196 6290284 394534..395142 1 NC_010677.1 lipoprotein 395142 6290284 FTM_0358 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891180.1 394534 D 441952 CDS YP_001891181.1 187931197 6291193 395199..396629 1 NC_010677.1 hypothetical protein 396629 6291193 FTM_0359 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891181.1 395199 D 441952 CDS YP_001891182.1 187931198 6291554 396640..397623 1 NC_010677.1 hypothetical protein 397623 6291554 FTM_0360 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891182.1 396640 D 441952 CDS YP_001891183.1 187931199 6291573 397629..399023 1 NC_010677.1 lipoprotein 399023 6291573 FTM_0361 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891183.1 397629 D 441952 CDS YP_001891184.1 187931200 6290647 399163..400077 1 NC_010677.1 hypothetical protein 400077 6290647 FTM_0362 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891184.1 399163 D 441952 CDS YP_001891185.1 187931201 6290696 401409..402824 1 NC_010677.1 putative nicotinate phosphoribosyltransferase 402824 6290696 FTM_0364 Francisella tularensis subsp. mediasiatica FSC147 putative nicotinate phosphoribosyltransferase YP_001891185.1 401409 D 441952 CDS YP_001891186.1 187931202 6290904 complement(404402..404890) 1 NC_010677.1 thioesterase family protein 404890 6290904 FTM_0366 Francisella tularensis subsp. mediasiatica FSC147 thioesterase family protein YP_001891186.1 404402 R 441952 CDS YP_001891187.1 187931203 6290562 complement(404952..406139) 1 NC_010677.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 406139 fadA 6290562 fadA Francisella tularensis subsp. mediasiatica FSC147 acetyl-CoA acetyltransferase YP_001891187.1 404952 R 441952 CDS YP_001891188.1 187931204 6290346 complement(406152..408848) 1 NC_010677.1 bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein 408848 6290346 FTM_0368 Francisella tularensis subsp. mediasiatica FSC147 bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein YP_001891188.1 406152 R 441952 CDS YP_001891189.1 187931205 6290767 complement(408921..411161) 1 NC_010677.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 411161 fadE 6290767 fadE Francisella tularensis subsp. mediasiatica FSC147 acyl-CoA dehydrogenase YP_001891189.1 408921 R 441952 CDS YP_001891190.1 187931206 6290653 complement(411199..412887) 1 NC_010677.1 long chain fatty acid-CoA ligase 412887 fadD 6290653 fadD Francisella tularensis subsp. mediasiatica FSC147 long chain fatty acid-CoA ligase YP_001891190.1 411199 R 441952 CDS YP_001891191.1 187931207 6290855 413031..413450 1 NC_010677.1 arsenate reductase 413450 6290855 FTM_0371 Francisella tularensis subsp. mediasiatica FSC147 arsenate reductase YP_001891191.1 413031 D 441952 CDS YP_001891192.1 187931208 6291670 413499..415715 1 NC_010677.1 isocitrate dehydrogenase 415715 icd 6291670 icd Francisella tularensis subsp. mediasiatica FSC147 isocitrate dehydrogenase YP_001891192.1 413499 D 441952 CDS YP_001891193.1 187931209 6291196 415729..416616 1 NC_010677.1 membrane protein 416616 6291196 FTM_0373 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891193.1 415729 D 441952 CDS YP_001891194.1 187931210 6291347 416640..420908 1 NC_010677.1 ATP-dependent helicase HrpA 420908 hrpA 6291347 hrpA Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent helicase HrpA YP_001891194.1 416640 D 441952 CDS YP_001891195.1 187931211 6290342 422409..423092 1 NC_010677.1 hypothetical protein 423092 6290342 FTM_0375 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891195.1 422409 D 441952 CDS YP_001891196.1 187931212 6291280 complement(426155..426727) 1 NC_010677.1 methylated DNA protein cysteine methyltransferase 426727 6291280 FTM_0379 Francisella tularensis subsp. mediasiatica FSC147 methylated DNA protein cysteine methyltransferase YP_001891196.1 426155 R 441952 CDS YP_001891197.1 187931213 6290148 426757..427476 1 NC_010677.1 hypothetical protein 427476 6290148 FTM_0380 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891197.1 426757 D 441952 CDS YP_001891198.1 187931214 6290333 427479..428897 1 NC_010677.1 dihydrolipoamide dehydrogenase 428897 6290333 FTM_0381 Francisella tularensis subsp. mediasiatica FSC147 dihydrolipoamide dehydrogenase YP_001891198.1 427479 D 441952 CDS YP_001891199.1 187931215 6290859 428894..429439 1 NC_010677.1 phosphatidyltransferase 429439 6290859 FTM_0382 Francisella tularensis subsp. mediasiatica FSC147 phosphatidyltransferase YP_001891199.1 428894 D 441952 CDS YP_001891200.1 187931216 6290409 430639..431565 1 NC_010677.1 subunit of DnaJ/DnaK/GrpE 431565 6290409 FTM_0385 Francisella tularensis subsp. mediasiatica FSC147 subunit of DnaJ/DnaK/GrpE YP_001891200.1 430639 D 441952 CDS YP_001891201.1 187931217 6290793 complement(431555..432439) 1 NC_010677.1 drug/metabolite exporter protein 432439 6290793 FTM_0386 Francisella tularensis subsp. mediasiatica FSC147 drug/metabolite exporter protein YP_001891201.1 431555 R 441952 CDS YP_001891202.1 187931218 6291564 433532..433888 1 NC_010677.1 hypothetical protein 433888 6291564 FTM_0388 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891202.1 433532 D 441952 CDS YP_001891203.1 187931219 6290404 434192..436201 1 NC_010677.1 GDP pyrophosphokinase/GTP pyrophosphokinase 436201 relA 6290404 relA Francisella tularensis subsp. mediasiatica FSC147 GDP pyrophosphokinase/GTP pyrophosphokinase YP_001891203.1 434192 D 441952 CDS YP_001891204.1 187931220 6291451 complement(436317..436949) 1 NC_010677.1 hypothetical protein 436949 6291451 FTM_0390 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891204.1 436317 R 441952 CDS YP_001891205.1 187931221 6290297 437695..438309 1 NC_010677.1 membrane protein 438309 6290297 FTM_0392 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891205.1 437695 D 441952 CDS YP_001891206.1 187931222 6290328 complement(438316..439041) 1 NC_010677.1 hypothetical protein 439041 6290328 FTM_0393 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891206.1 438316 R 441952 CDS YP_001891207.1 187931223 6290968 complement(439041..439919) 1 NC_010677.1 site-specific recombinase 439919 xerC 6290968 xerC Francisella tularensis subsp. mediasiatica FSC147 site-specific recombinase YP_001891207.1 439041 R 441952 CDS YP_001891208.1 187931224 6290225 complement(439929..441101) 1 NC_010677.1 hydroxy/aromatic amino acid permease (HAAAP) family protein 441101 6290225 FTM_0395 Francisella tularensis subsp. mediasiatica FSC147 hydroxy/aromatic amino acid permease (HAAAP) family protein YP_001891208.1 439929 R 441952 CDS YP_001891209.1 187931225 6290864 complement(442579..443022) 1 NC_010677.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 443022 secB2 6290864 secB2 Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecB YP_001891209.1 442579 R 441952 CDS YP_001891210.1 187931226 6290338 complement(443099..445633) 1 NC_010677.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 445633 mutS 6290338 mutS Francisella tularensis subsp. mediasiatica FSC147 DNA mismatch repair protein MutS YP_001891210.1 443099 R 441952 CDS YP_001891211.1 187931227 6291064 445800..446747 1 NC_010677.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 446747 accA 6291064 accA Francisella tularensis subsp. mediasiatica FSC147 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_001891211.1 445800 D 441952 CDS YP_001891212.1 187931228 6290343 446767..447270 1 NC_010677.1 pilus assembly protein 447270 6290343 FTM_0400 Francisella tularensis subsp. mediasiatica FSC147 pilus assembly protein YP_001891212.1 446767 D 441952 CDS YP_001891213.1 187931229 6290469 447251..448264 1 NC_010677.1 pilus assembly protein 448264 6290469 FTM_0401 Francisella tularensis subsp. mediasiatica FSC147 pilus assembly protein YP_001891213.1 447251 D 441952 CDS YP_001891214.1 187931230 6291703 448273..450237 1 NC_010677.1 membrane protein 450237 6291703 FTM_0402 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891214.1 448273 D 441952 CDS YP_001891215.1 187931231 6290852 450234..451118 1 NC_010677.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 451118 murQ 6290852 murQ Francisella tularensis subsp. mediasiatica FSC147 N-acetylmuramic acid 6-phosphate etherase YP_001891215.1 450234 D 441952 CDS YP_001891216.1 187931232 6290232 451120..451512 1 NC_010677.1 hypothetical protein 451512 6290232 FTM_0404 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891216.1 451120 D 441952 CDS YP_001891217.1 187931233 6290451 complement(454242..455540) 1 NC_010677.1 monovalent cation:proton antiporter-1 455540 6290451 FTM_0406 Francisella tularensis subsp. mediasiatica FSC147 monovalent cation:proton antiporter-1 YP_001891217.1 454242 R 441952 CDS YP_001891218.1 187931234 6290722 complement(455550..456275) 1 NC_010677.1 hypothetical protein 456275 6290722 FTM_0407 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891218.1 455550 R 441952 CDS YP_001891219.1 187931235 6290655 complement(456277..457281) 1 NC_010677.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 457281 trpS 6290655 trpS Francisella tularensis subsp. mediasiatica FSC147 tryptophanyl-tRNA synthetase YP_001891219.1 456277 R 441952 CDS YP_001891220.1 187931236 6290511 complement(457578..458192) 1 NC_010677.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 458192 coaE 6290511 coaE Francisella tularensis subsp. mediasiatica FSC147 dephospho-CoA kinase YP_001891220.1 457578 R 441952 CDS YP_001891221.1 187931237 6291509 458321..459457 1 NC_010677.1 hypothetical protein 459457 6291509 FTM_0412 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891221.1 458321 D 441952 CDS YP_001891222.1 187931238 6290756 459757..462438 1 NC_010677.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 462438 aceE 6290756 aceE Francisella tularensis subsp. mediasiatica FSC147 pyruvate dehydrogenase subunit E1 YP_001891222.1 459757 D 441952 CDS YP_001891223.1 187931239 6290774 462456..464039 1 NC_010677.1 Deletion of 104 aa in FTM that is not present in SCHU; dihydrolipoamide acetyltransferase 464039 aceF 6290774 aceF Francisella tularensis subsp. mediasiatica FSC147 dihydrolipoamide acetyltransferase YP_001891223.1 462456 D 441952 CDS YP_001891224.1 187931240 6290324 464053..465477 1 NC_010677.1 pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase 465477 lpdA 6290324 lpdA Francisella tularensis subsp. mediasiatica FSC147 pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase YP_001891224.1 464053 D 441952 CDS YP_001891225.1 187931241 6291570 466696..467343 1 NC_010677.1 MutT/nudix family protein 467343 6291570 FTM_0416 Francisella tularensis subsp. mediasiatica FSC147 MutT/nudix family protein YP_001891225.1 466696 D 441952 CDS YP_001891226.1 187931242 6290682 467361..467714 1 NC_010677.1 arsenate reductase 467714 6290682 FTM_0417 Francisella tularensis subsp. mediasiatica FSC147 arsenate reductase YP_001891226.1 467361 D 441952 CDS YP_001891227.1 187931243 6291449 complement(467738..468073) 1 NC_010677.1 lipoprotein 468073 6291449 FTM_0418 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891227.1 467738 R 441952 CDS YP_001891228.1 187931244 6291603 complement(468573..469886) 1 NC_010677.1 permease 469886 6291603 FTM_0419 Francisella tularensis subsp. mediasiatica FSC147 permease YP_001891228.1 468573 R 441952 CDS YP_001891229.1 187931245 6290364 complement(469953..471539) 1 NC_010677.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 471539 6290364 FTM_0420 Francisella tularensis subsp. mediasiatica FSC147 aspartate aminotransferase YP_001891229.1 469953 R 441952 CDS YP_001891230.1 187931246 6291388 complement(474447..475700) 1 NC_010677.1 OmpA family protein 475700 6291388 FTM_0423 Francisella tularensis subsp. mediasiatica FSC147 OmpA family protein YP_001891230.1 474447 R 441952 CDS YP_001891231.1 187931247 6290841 475892..476356 1 NC_010677.1 fkbp-type 16 kda peptidyl-prolyl cis-transisomerase 476356 fkpB 6290841 fkpB Francisella tularensis subsp. mediasiatica FSC147 fkbp-type 16 kda peptidyl-prolyl cis-transisomerase YP_001891231.1 475892 D 441952 CDS YP_001891232.1 187931248 6291106 476337..477293 1 NC_010677.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 477293 ispH 6291106 ispH Francisella tularensis subsp. mediasiatica FSC147 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001891232.1 476337 D 441952 CDS YP_001891233.1 187931249 6290839 477295..477657 1 NC_010677.1 chorismate mutase 477657 aroH 6290839 aroH Francisella tularensis subsp. mediasiatica FSC147 chorismate mutase YP_001891233.1 477295 D 441952 CDS YP_001891234.1 187931250 6290828 477666..478487 1 NC_010677.1 phosphatidylserine synthase 478487 pssA 6290828 pssA Francisella tularensis subsp. mediasiatica FSC147 phosphatidylserine synthase YP_001891234.1 477666 D 441952 CDS YP_001891235.1 187931251 6290354 complement(478492..478716) 1 NC_010677.1 lipoprotein 478716 6290354 FTM_0428 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891235.1 478492 R 441952 CDS YP_001891236.1 187931252 6290489 478869..479576 1 NC_010677.1 group A colicin translocation protein TolQ 479576 tolQ 6290489 tolQ Francisella tularensis subsp. mediasiatica FSC147 group A colicin translocation protein TolQ YP_001891236.1 478869 D 441952 CDS YP_001891237.1 187931253 6290835 479592..480032 1 NC_010677.1 group A colicin translocation protein TolR 480032 tolR 6290835 tolR Francisella tularensis subsp. mediasiatica FSC147 group A colicin translocation protein TolR YP_001891237.1 479592 D 441952 CDS YP_001891238.1 187931254 6291545 480019..480906 1 NC_010677.1 group A colicin translocation protein TolA 480906 tolA 6291545 tolA Francisella tularensis subsp. mediasiatica FSC147 group A colicin translocation protein TolA YP_001891238.1 480019 D 441952 CDS YP_001891239.1 187931255 6290561 480918..482225 1 NC_010677.1 group A colicin translocation protein TolB 482225 tolB 6290561 tolB Francisella tularensis subsp. mediasiatica FSC147 group A colicin translocation protein TolB YP_001891239.1 480918 D 441952 CDS YP_001891240.1 187931256 6290344 482235..482480 1 NC_010677.1 lipoprotein 482480 6290344 FTM_0433 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891240.1 482235 D 441952 CDS YP_001891241.1 187931257 6290997 482499..483122 1 NC_010677.1 peptidoglycan-associated lipoprotein 483122 pal 6290997 pal Francisella tularensis subsp. mediasiatica FSC147 peptidoglycan-associated lipoprotein YP_001891241.1 482499 D 441952 CDS YP_001891242.1 187931258 6291661 484653..485375 1 NC_010677.1 short-chain dehydrogenase/reductase SDR 485375 6291661 FTM_0436 Francisella tularensis subsp. mediasiatica FSC147 short-chain dehydrogenase/reductase SDR YP_001891242.1 484653 D 441952 CDS YP_001891243.1 187931259 6290290 485438..485629 1 NC_010677.1 hypothetical protein 485629 6290290 FTM_0437 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891243.1 485438 D 441952 CDS YP_001891244.1 187931260 6290700 485610..487109 1 NC_010677.1 deoxyribodipyrimidine photolyase 487109 6290700 FTM_0438 Francisella tularensis subsp. mediasiatica FSC147 deoxyribodipyrimidine photolyase YP_001891244.1 485610 D 441952 CDS YP_001891245.1 187931261 6291385 488896..489825 1 NC_010677.1 bile acid symporter family protein 489825 6291385 FTM_0440 Francisella tularensis subsp. mediasiatica FSC147 bile acid symporter family protein YP_001891245.1 488896 D 441952 CDS YP_001891246.1 187931262 6290442 490519..491277 1 NC_010677.1 hypothetical protein 491277 6290442 FTM_0442 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891246.1 490519 D 441952 CDS YP_001891247.1 187931263 6290801 491814..492800 1 NC_010677.1 hypothetical protein 492800 6290801 FTM_0444 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891247.1 491814 D 441952 CDS YP_001891248.1 187931264 6291666 493061..494209 1 NC_010677.1 ORF shortened compared to SCHU and novicida. RBS site more suited to shorter version; arsenite permease family protein 494209 6291666 FTM_0445 Francisella tularensis subsp. mediasiatica FSC147 arsenite permease family protein YP_001891248.1 493061 D 441952 CDS YP_001891249.1 187931265 6290431 complement(494188..494610) 1 NC_010677.1 hypothetical protein 494610 6290431 FTM_0446 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891249.1 494188 R 441952 CDS YP_001891250.1 187931266 6291234 complement(494630..494989) 1 NC_010677.1 hypothetical protein 494989 6291234 FTM_0447 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891250.1 494630 R 441952 CDS YP_001891251.1 187931267 6290375 complement(495003..495857) 1 NC_010677.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase 495857 ubiA 6290375 ubiA Francisella tularensis subsp. mediasiatica FSC147 4-hydroxybenzoate polyprenyltransferase YP_001891251.1 495003 R 441952 CDS YP_001891252.1 187931268 6291532 complement(495860..496366) 1 NC_010677.1 chorismate pyruvate lyase 496366 ubiC 6291532 ubiC Francisella tularensis subsp. mediasiatica FSC147 chorismate pyruvate lyase YP_001891252.1 495860 R 441952 CDS YP_001891253.1 187931269 6290584 496465..497172 1 NC_010677.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 497172 rph 6290584 rph Francisella tularensis subsp. mediasiatica FSC147 ribonuclease PH YP_001891253.1 496465 D 441952 CDS YP_001891254.1 187931270 6290306 complement(497226..497549) 1 NC_010677.1 hypothetical protein 497549 6290306 FTM_0451 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891254.1 497226 R 441952 CDS YP_001891255.1 187931271 6291546 complement(498666..499739) 1 NC_010677.1 putative metalloprotease; heat shock protein HtpX 499739 htpX 6291546 htpX Francisella tularensis subsp. mediasiatica FSC147 heat shock protein HtpX YP_001891255.1 498666 R 441952 CDS YP_001891256.1 187931272 6290889 complement(499743..500318) 1 NC_010677.1 LemA-like protein 500318 6290889 FTM_0454 Francisella tularensis subsp. mediasiatica FSC147 LemA-like protein YP_001891256.1 499743 R 441952 CDS YP_001891257.1 187931273 6290895 501402..502457 1 NC_010677.1 hypothetical protein 502457 6290895 FTM_0456 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891257.1 501402 D 441952 CDS YP_001891258.1 187931274 6290907 complement(503853..504218) 1 NC_010677.1 ArsR family transcriptional regulator 504218 6290907 FTM_0458 Francisella tularensis subsp. mediasiatica FSC147 ArsR family transcriptional regulator YP_001891258.1 503853 R 441952 CDS YP_001891259.1 187931275 6290911 505334..506332 1 NC_010677.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 506332 gpsA 6290911 gpsA Francisella tularensis subsp. mediasiatica FSC147 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001891259.1 505334 D 441952 CDS YP_001891260.1 187931276 6290916 complement(506333..506869) 1 NC_010677.1 hypothetical protein 506869 6290916 FTM_0461 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891260.1 506333 R 441952 CDS YP_001891261.1 187931277 6290920 complement(506874..508244) 1 NC_010677.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 508244 radA 6290920 radA Francisella tularensis subsp. mediasiatica FSC147 DNA repair protein RadA YP_001891261.1 506874 R 441952 CDS YP_001891262.1 187931278 6290928 complement(508252..509022) 1 NC_010677.1 hypothetical protein 509022 6290928 FTM_0463 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891262.1 508252 R 441952 CDS YP_001891263.1 187931279 6290936 complement(509019..509618) 1 NC_010677.1 membrane protein 509618 6290936 FTM_0464 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891263.1 509019 R 441952 CDS YP_001891264.1 187931280 6290940 complement(509621..510679) 1 NC_010677.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 510679 aroC 6290940 aroC Francisella tularensis subsp. mediasiatica FSC147 chorismate synthase YP_001891264.1 509621 R 441952 CDS YP_001891265.1 187931281 6290944 complement(510819..511472) 1 NC_010677.1 membrane protein 511472 6290944 FTM_0466 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891265.1 510819 R 441952 CDS YP_001891266.1 187931282 6290946 complement(511487..511999) 1 NC_010677.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 511999 6290946 FTM_0467 Francisella tularensis subsp. mediasiatica FSC147 methionine sulfoxide reductase B YP_001891266.1 511487 R 441952 CDS YP_001891267.1 187931283 6290948 512160..512717 1 NC_010677.1 copper/zinc superoxide dismutase 512717 sodC 6290948 sodC Francisella tularensis subsp. mediasiatica FSC147 copper/zinc superoxide dismutase YP_001891267.1 512160 D 441952 CDS YP_001891268.1 187931284 6290949 512721..513512 1 NC_010677.1 sterol desaturase 513512 6290949 FTM_0469 Francisella tularensis subsp. mediasiatica FSC147 sterol desaturase YP_001891268.1 512721 D 441952 CDS YP_001891269.1 187931285 6290953 complement(513487..514881) 1 NC_010677.1 amino acid transporter (AAT) family protein 514881 6290953 FTM_0470 Francisella tularensis subsp. mediasiatica FSC147 amino acid transporter (AAT) family protein YP_001891269.1 513487 R 441952 CDS YP_001891270.1 187931286 6290963 515486..516598 1 NC_010677.1 Zn-dependent alcohol dehydrogenase 516598 6290963 FTM_0472 Francisella tularensis subsp. mediasiatica FSC147 Zn-dependent alcohol dehydrogenase YP_001891270.1 515486 D 441952 CDS YP_001891271.1 187931287 6290970 complement(516647..517837) 1 NC_010677.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 517837 6290970 FTM_0473 Francisella tularensis subsp. mediasiatica FSC147 aspartate aminotransferase YP_001891271.1 516647 R 441952 CDS YP_001891272.1 187931288 6290975 518040..518927 1 NC_010677.1 cation diffusion facilitator (CDF) family protein 518927 6290975 FTM_0474 Francisella tularensis subsp. mediasiatica FSC147 cation diffusion facilitator (CDF) family protein YP_001891272.1 518040 D 441952 CDS YP_001891273.1 187931289 6290990 519013..520662 1 NC_010677.1 DNA repair protein RecN 520662 recN 6290990 recN Francisella tularensis subsp. mediasiatica FSC147 DNA repair protein RecN YP_001891273.1 519013 D 441952 CDS YP_001891274.1 187931290 6291003 complement(522866..523306) 1 NC_010677.1 Type IV pili, pilus assembly protein 523306 6291003 FTM_0477 Francisella tularensis subsp. mediasiatica FSC147 Type IV pili, pilus assembly protein YP_001891274.1 522866 R 441952 CDS YP_001891275.1 187931291 6291004 complement(523437..523844) 1 NC_010677.1 Type IV pili, pilus assembly protein 523844 pilA 6291004 pilA Francisella tularensis subsp. mediasiatica FSC147 Type IV pili, pilus assembly protein YP_001891275.1 523437 R 441952 CDS YP_001891276.1 187931292 6291007 524226..524945 1 NC_010677.1 lipid A 1-phosphatase 524945 lpxE 6291007 lpxE Francisella tularensis subsp. mediasiatica FSC147 lipid A 1-phosphatase YP_001891276.1 524226 D 441952 CDS YP_001891277.1 187931293 6291009 525084..525932 1 NC_010677.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 525932 folD 6291009 folD Francisella tularensis subsp. mediasiatica FSC147 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001891277.1 525084 D 441952 CDS YP_001891278.1 187931294 6291012 526166..527209 1 NC_010677.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 527209 purM 6291012 purM Francisella tularensis subsp. mediasiatica FSC147 phosphoribosylaminoimidazole synthetase YP_001891278.1 526166 D 441952 CDS YP_001891279.1 187931295 6291017 527209..529521 1 NC_010677.1 saicar synthetase/phosphoribosylamine-glycine ligase 529521 6291017 FTM_0482 Francisella tularensis subsp. mediasiatica FSC147 saicar synthetase/phosphoribosylamine-glycine ligase YP_001891279.1 527209 D 441952 CDS YP_001891280.1 187931296 6291031 529525..530100 1 NC_010677.1 phosphoribosylglycinamide formyltransferase 530100 purN 6291031 purN Francisella tularensis subsp. mediasiatica FSC147 phosphoribosylglycinamide formyltransferase YP_001891280.1 529525 D 441952 CDS YP_001891281.1 187931297 6291034 530217..530708 1 NC_010677.1 N5-carboxyaminoimidazole ribonucleotide mutase 530708 purE 6291034 purE Francisella tularensis subsp. mediasiatica FSC147 N5-carboxyaminoimidazole ribonucleotide mutase YP_001891281.1 530217 D 441952 CDS YP_001891282.1 187931298 6291045 530712..531809 1 NC_010677.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 531809 purK 6291045 purK Francisella tularensis subsp. mediasiatica FSC147 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_001891282.1 530712 D 441952 CDS YP_001891283.1 187931299 6291049 complement(531806..532159) 1 NC_010677.1 hypothetical protein 532159 6291049 FTM_0486 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891283.1 531806 R 441952 CDS YP_001891284.1 187931300 6291051 complement(532226..534247) 1 NC_010677.1 oligopeptidase A 534247 prlC 6291051 prlC Francisella tularensis subsp. mediasiatica FSC147 oligopeptidase A YP_001891284.1 532226 R 441952 CDS YP_001891285.1 187931301 6291058 534339..534710 1 NC_010677.1 membrane protein 534710 6291058 FTM_0488 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891285.1 534339 D 441952 CDS YP_001891286.1 187931302 6291060 534786..535235 1 NC_010677.1 hypothetical protein 535235 6291060 FTM_0489 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891286.1 534786 D 441952 CDS YP_001891287.1 187931303 6291062 535392..535871 1 NC_010677.1 lipoprotein 535871 6291062 FTM_0490 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891287.1 535392 D 441952 CDS YP_001891288.1 187931304 6291071 536507..536974 1 NC_010677.1 hypothetical protein 536974 6291071 FTM_0492 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891288.1 536507 D 441952 CDS YP_001891289.1 187931305 6291077 537047..538489 1 NC_010677.1 hypothetical protein 538489 6291077 FTM_0493 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891289.1 537047 D 441952 CDS YP_001891290.1 187931306 6291079 complement(538543..540837) 1 NC_010677.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I 540837 topA 6291079 topA Francisella tularensis subsp. mediasiatica FSC147 DNA topoisomerase I YP_001891290.1 538543 R 441952 CDS YP_001891291.1 187931307 6291092 541036..541677 1 NC_010677.1 chmomosome partition protein A 541677 parA 6291092 parA Francisella tularensis subsp. mediasiatica FSC147 chmomosome partition protein A YP_001891291.1 541036 D 441952 CDS YP_001891292.1 187931308 6291098 541670..542584 1 NC_010677.1 chromosome partition protein B 542584 parB 6291098 parB Francisella tularensis subsp. mediasiatica FSC147 chromosome partition protein B YP_001891292.1 541670 D 441952 CDS YP_001891293.1 187931309 6291108 542598..543305 1 NC_010677.1 glutamine amidotransferase 543305 6291108 FTM_0497 Francisella tularensis subsp. mediasiatica FSC147 glutamine amidotransferase YP_001891293.1 542598 D 441952 CDS YP_001891294.1 187931310 6291119 543308..544189 1 NC_010677.1 lipolytic protein 544189 6291119 FTM_0498 Francisella tularensis subsp. mediasiatica FSC147 lipolytic protein YP_001891294.1 543308 D 441952 CDS YP_001891295.1 187931311 6291126 complement(544835..545455) 1 NC_010677.1 23S rRNA methylase 545455 rrmJ 6291126 rrmJ Francisella tularensis subsp. mediasiatica FSC147 23S rRNA methylase YP_001891295.1 544835 R 441952 CDS YP_001891296.1 187931312 6291139 545613..546080 1 NC_010677.1 hypothetical protein 546080 6291139 FTM_0501 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891296.1 545613 D 441952 CDS YP_001891297.1 187931313 6291152 complement(546075..546560) 1 NC_010677.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 546560 lspA 6291152 lspA Francisella tularensis subsp. mediasiatica FSC147 lipoprotein signal peptidase YP_001891297.1 546075 R 441952 CDS YP_001891298.1 187931314 6291158 complement(546547..549354) 1 NC_010677.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 549354 ileS 6291158 ileS Francisella tularensis subsp. mediasiatica FSC147 isoleucyl-tRNA synthetase YP_001891298.1 546547 R 441952 CDS YP_001891299.1 187931315 6291162 complement(549447..550367) 1 NC_010677.1 riboflavin kinase/FMN adenylyltransferase 550367 ribF 6291162 ribF Francisella tularensis subsp. mediasiatica FSC147 riboflavin kinase/FMN adenylyltransferase YP_001891299.1 549447 R 441952 CDS YP_001891300.1 187931316 6291163 550518..552332 1 NC_010677.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 552332 maeA 6291163 maeA Francisella tularensis subsp. mediasiatica FSC147 malate dehydrogenase YP_001891300.1 550518 D 441952 CDS YP_001891301.1 187931317 6291166 552495..554168 1 NC_010677.1 lipoprotein 554168 6291166 FTM_0506 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891301.1 552495 D 441952 CDS YP_001891302.1 187931318 6291169 554185..555630 1 NC_010677.1 hypothetical protein 555630 6291169 FTM_0507 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891302.1 554185 D 441952 CDS YP_001891303.1 187931319 6291179 557523..558041 1 NC_010677.1 hypothetical protein 558041 6291179 FTM_0509 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891303.1 557523 D 441952 CDS YP_001891304.1 187931320 6291184 558258..559655 1 NC_010677.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 559655 engA 6291184 engA Francisella tularensis subsp. mediasiatica FSC147 GTP-binding protein EngA YP_001891304.1 558258 D 441952 CDS YP_001891305.1 187931321 6291188 559624..560928 1 NC_010677.1 UDP-N-acetylglucosamine enolpyruvoyl transferase 560928 murA 6291188 murA Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylglucosamine enolpyruvoyl transferase YP_001891305.1 559624 D 441952 CDS YP_001891306.1 187931322 6291190 560936..561784 1 NC_010677.1 UDP-N-acetylmuramate dehydrogenase 561784 murB 6291190 murB Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylmuramate dehydrogenase YP_001891306.1 560936 D 441952 CDS YP_001891307.1 187931323 6291195 561863..562738 1 NC_010677.1 hypothetical protein 562738 6291195 FTM_0513 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891307.1 561863 D 441952 CDS YP_001891308.1 187931324 6291197 complement(562740..563516) 1 NC_010677.1 hypothetical protein 563516 6291197 FTM_0514 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891308.1 562740 R 441952 CDS YP_001891309.1 187931325 6291203 complement(564707..565045) 1 NC_010677.1 histidine triad (HIT) family protein 565045 hitA 6291203 hitA Francisella tularensis subsp. mediasiatica FSC147 histidine triad (HIT) family protein YP_001891309.1 564707 R 441952 CDS YP_001891310.1 187931326 6291205 complement(565051..566709) 1 NC_010677.1 2-octaprenylphenol hydroxylase 566709 ubiB 6291205 ubiB Francisella tularensis subsp. mediasiatica FSC147 2-octaprenylphenol hydroxylase YP_001891310.1 565051 R 441952 CDS YP_001891311.1 187931327 6291209 complement(566702..567289) 1 NC_010677.1 hypothetical protein 567289 6291209 FTM_0518 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891311.1 566702 R 441952 CDS YP_001891312.1 187931328 6291216 complement(567291..568043) 1 NC_010677.1 ubiquinone/menaquinone biosynthesis methyltransferase UbiE 568043 ubiE 6291216 ubiE Francisella tularensis subsp. mediasiatica FSC147 ubiquinone/menaquinone biosynthesis methyltransferase UbiE YP_001891312.1 567291 R 441952 CDS YP_001891313.1 187931329 6291218 568137..569153 1 NC_010677.1 glucokinase 569153 glk 6291218 glk Francisella tularensis subsp. mediasiatica FSC147 glucokinase YP_001891313.1 568137 D 441952 CDS YP_001891314.1 187931330 6291637 complement(569467..569997) 1 NC_010677.1 intracellular septation protein A family protein 569997 ispZ 6291637 ispZ Francisella tularensis subsp. mediasiatica FSC147 intracellular septation protein A family protein YP_001891314.1 569467 R 441952 CDS YP_001891315.1 187931331 6291222 570058..570672 1 NC_010677.1 Sua5/YciO/YrdC family protein 570672 6291222 FTM_0522 Francisella tularensis subsp. mediasiatica FSC147 Sua5/YciO/YrdC family protein YP_001891315.1 570058 D 441952 CDS YP_001891316.1 187931332 6291224 570722..571324 1 NC_010677.1 hypothetical protein 571324 6291224 FTM_0523 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891316.1 570722 D 441952 CDS YP_001891317.1 187931333 6291226 complement(571321..572544) 1 NC_010677.1 major facilitator superfamily protein 572544 6291226 FTM_0524 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily protein YP_001891317.1 571321 R 441952 CDS YP_001891318.1 187931334 6291275 complement(575575..575832) 1 NC_010677.1 hypothetical protein 575832 6291275 FTM_0529 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891318.1 575575 R 441952 CDS YP_001891319.1 187931335 6291346 complement(582489..583544) 1 NC_010677.1 hypothetical protein 583544 6291346 FTM_0536 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891319.1 582489 R 441952 CDS YP_001891320.1 187931336 6291358 complement(583677..584333) 1 NC_010677.1 metallopeptidase 584333 6291358 FTM_0537 Francisella tularensis subsp. mediasiatica FSC147 metallopeptidase YP_001891320.1 583677 R 441952 CDS YP_001891321.1 187931337 6291363 586480..586815 1 NC_010677.1 hypothetical protein 586815 6291363 FTM_0538 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891321.1 586480 D 441952 CDS YP_001891322.1 187931338 6291369 complement(586788..587639) 1 NC_010677.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 587639 psd 6291369 psd Francisella tularensis subsp. mediasiatica FSC147 phosphatidylserine decarboxylase YP_001891322.1 586788 R 441952 CDS YP_001891323.1 187931339 6291378 587739..588719 1 NC_010677.1 hypothetical protein 588719 6291378 FTM_0540 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891323.1 587739 D 441952 CDS YP_001891324.1 187931340 6291380 588728..589771 1 NC_010677.1 NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways; bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase 589771 6291380 FTM_0541 Francisella tularensis subsp. mediasiatica FSC147 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase YP_001891324.1 588728 D 441952 CDS YP_001891325.1 187931341 6291389 589785..591152 1 NC_010677.1 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase 591152 glmU 6291389 glmU Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase YP_001891325.1 589785 D 441952 CDS YP_001891326.1 187931342 6291402 591173..593011 1 NC_010677.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 593011 glmS 6291402 glmS Francisella tularensis subsp. mediasiatica FSC147 glucosamine--fructose-6-phosphate aminotransferase YP_001891326.1 591173 D 441952 CDS YP_001891327.1 187931343 6291406 complement(593612..593809) 1 NC_010677.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 593809 rpsU 6291406 rpsU Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S21 YP_001891327.1 593612 R 441952 CDS YP_001891328.1 187931344 6291421 complement(593809..594012) 1 NC_010677.1 cold shock protein, DNA-binding 594012 cspC 6291421 cspC Francisella tularensis subsp. mediasiatica FSC147 cold shock protein, DNA-binding YP_001891328.1 593809 R 441952 CDS YP_001891329.1 187931345 6291425 complement(594261..594590) 1 NC_010677.1 hypothetical protein 594590 6291425 FTM_0547 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891329.1 594261 R 441952 CDS YP_001891330.1 187931346 6291453 594717..595487 1 NC_010677.1 methionine aminopeptidase 595487 map 6291453 map Francisella tularensis subsp. mediasiatica FSC147 methionine aminopeptidase YP_001891330.1 594717 D 441952 CDS YP_001891331.1 187931347 6291455 595489..596337 1 NC_010677.1 hypothetical protein 596337 6291455 FTM_0549 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891331.1 595489 D 441952 CDS YP_001891332.1 187931348 6291465 597224..599449 1 NC_010677.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 599449 parC 6291465 parC Francisella tularensis subsp. mediasiatica FSC147 DNA topoisomerase IV subunit A YP_001891332.1 597224 D 441952 CDS YP_001891333.1 187931349 6291469 599449..600135 1 NC_010677.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 600135 mtn 6291469 mtn Francisella tularensis subsp. mediasiatica FSC147 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_001891333.1 599449 D 441952 CDS YP_001891334.1 187931350 6291472 complement(600122..600721) 1 NC_010677.1 membrane protein 600721 6291472 FTM_0553 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891334.1 600122 R 441952 CDS YP_001891335.1 187931351 6291477 complement(600714..601832) 1 NC_010677.1 BNR/Asp-box repeat-containing protein 601832 6291477 FTM_0554 Francisella tularensis subsp. mediasiatica FSC147 BNR/Asp-box repeat-containing protein YP_001891335.1 600714 R 441952 CDS YP_001891336.1 187931352 6291508 602031..604007 1 NC_010677.1 soluble lytic murein transglycosylase 604007 slt 6291508 slt Francisella tularensis subsp. mediasiatica FSC147 soluble lytic murein transglycosylase YP_001891336.1 602031 D 441952 CDS YP_001891337.1 187931353 6291522 complement(604021..604656) 1 NC_010677.1 hypothetical protein 604656 6291522 FTM_0556 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891337.1 604021 R 441952 CDS YP_001891338.1 187931354 6291529 605009..606163 1 NC_010677.1 membrane protein 606163 6291529 FTM_0557 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891338.1 605009 D 441952 CDS YP_001891339.1 187931355 6291531 606520..609999 1 NC_010677.1 DNA polymerase III subunit alpha 609999 6291531 FTM_0558 Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase III subunit alpha YP_001891339.1 606520 D 441952 CDS YP_001891340.1 187931356 6291560 611388..612650 1 NC_010677.1 ABC transporter involved in lipoprotein release, permease component 612650 6291560 FTM_0560 Francisella tularensis subsp. mediasiatica FSC147 ABC transporter involved in lipoprotein release, permease component YP_001891340.1 611388 D 441952 CDS YP_001891341.1 187931357 6291599 612643..613338 1 NC_010677.1 ABC transporter ATPase 613338 6291599 FTM_0561 Francisella tularensis subsp. mediasiatica FSC147 ABC transporter ATPase YP_001891341.1 612643 D 441952 CDS YP_001891342.1 187931358 6291614 615688..616764 1 NC_010677.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 616764 gcvT 6291614 gcvT Francisella tularensis subsp. mediasiatica FSC147 glycine cleavage system aminomethyltransferase T YP_001891342.1 615688 D 441952 CDS YP_001891343.1 187931359 6291643 616821..617204 1 NC_010677.1 glycine cleavage system H protein 617204 gcvH 6291643 gcvH Francisella tularensis subsp. mediasiatica FSC147 glycine cleavage system H protein YP_001891343.1 616821 D 441952 CDS YP_001891344.1 187931360 6291653 617269..618636 1 NC_010677.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 618636 gcvP1 6291653 gcvP1 Francisella tularensis subsp. mediasiatica FSC147 glycine dehydrogenase subunit 1 YP_001891344.1 617269 D 441952 CDS YP_001891345.1 187931361 6291659 618642..620087 1 NC_010677.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 620087 gcvP2 6291659 gcvP2 Francisella tularensis subsp. mediasiatica FSC147 glycine dehydrogenase subunit 2 YP_001891345.1 618642 D 441952 CDS YP_001891346.1 187931362 6291663 complement(620207..621052) 1 NC_010677.1 shikimate 5-dehydrogenase 621052 6291663 FTM_0567 Francisella tularensis subsp. mediasiatica FSC147 shikimate 5-dehydrogenase YP_001891346.1 620207 R 441952 CDS YP_001891347.1 187931363 6291665 complement(621078..624290) 1 NC_010677.1 pullulanase 624290 glgX 6291665 glgX Francisella tularensis subsp. mediasiatica FSC147 pullulanase YP_001891347.1 621078 R 441952 CDS YP_001891348.1 187931364 6291669 complement(624324..626246) 1 NC_010677.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 626246 glgB 6291669 glgB Francisella tularensis subsp. mediasiatica FSC147 glycogen branching protein YP_001891348.1 624324 R 441952 CDS YP_001891349.1 187931365 6291672 626548..628182 1 NC_010677.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 628182 pgm 6291672 pgm Francisella tularensis subsp. mediasiatica FSC147 phosphoglucomutase YP_001891349.1 626548 D 441952 CDS YP_001891350.1 187931366 6291673 628216..629487 1 NC_010677.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 629487 glgC 6291673 glgC Francisella tularensis subsp. mediasiatica FSC147 glucose-1-phosphate adenylyltransferase YP_001891350.1 628216 D 441952 CDS YP_001891351.1 187931367 6291674 629497..630966 1 NC_010677.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 630966 glgA 6291674 glgA Francisella tularensis subsp. mediasiatica FSC147 glycogen synthase YP_001891351.1 629497 D 441952 CDS YP_001891352.1 187931368 6291675 631071..633344 1 NC_010677.1 glycogen phosphorylase 633344 glgP 6291675 glgP Francisella tularensis subsp. mediasiatica FSC147 glycogen phosphorylase YP_001891352.1 631071 D 441952 CDS YP_001891353.1 187931369 6291677 633388..634851 1 NC_010677.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 634851 malQ 6291677 malQ Francisella tularensis subsp. mediasiatica FSC147 4-alpha-glucanotransferase YP_001891353.1 633388 D 441952 CDS YP_001891354.1 187931370 6291681 634943..635833 1 NC_010677.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 635833 glyQ 6291681 glyQ Francisella tularensis subsp. mediasiatica FSC147 glycyl-tRNA synthetase subunit alpha YP_001891354.1 634943 D 441952 CDS YP_001891355.1 187931371 6291682 636044..637483 1 NC_010677.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 637483 murE 6291682 murE Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001891355.1 636044 D 441952 CDS YP_001891356.1 187931372 6291683 637563..637922 1 NC_010677.1 outer membrane lipoprotein 637922 6291683 FTM_0577 Francisella tularensis subsp. mediasiatica FSC147 outer membrane lipoprotein YP_001891356.1 637563 D 441952 CDS YP_001891357.1 187931373 6291684 638274..639632 1 NC_010677.1 d-alanyl-d-alanine-adding enzyme 639632 murF 6291684 murF Francisella tularensis subsp. mediasiatica FSC147 d-alanyl-d-alanine-adding enzyme YP_001891357.1 638274 D 441952 CDS YP_001891358.1 187931374 6291685 639641..640459 1 NC_010677.1 hypothetical protein 640459 6291685 FTM_0579 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891358.1 639641 D 441952 CDS YP_001891359.1 187931375 6291690 641682..644102 1 NC_010677.1 aspartate kinase I/homoserine dehydrogenase I 644102 thrA 6291690 thrA Francisella tularensis subsp. mediasiatica FSC147 aspartate kinase I/homoserine dehydrogenase I YP_001891359.1 641682 D 441952 CDS YP_001891360.1 187931376 6291691 644105..645058 1 NC_010677.1 homoserine kinase 645058 thrB 6291691 thrB Francisella tularensis subsp. mediasiatica FSC147 homoserine kinase YP_001891360.1 644105 D 441952 CDS YP_001891361.1 187931377 6291699 646942..647430 1 NC_010677.1 S-adenosylmethionine decarboxylase 647430 6291699 FTM_0585 Francisella tularensis subsp. mediasiatica FSC147 S-adenosylmethionine decarboxylase YP_001891361.1 646942 D 441952 CDS YP_001891362.1 187931378 6291702 647430..648299 1 NC_010677.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 648299 6291702 FTM_0586 Francisella tularensis subsp. mediasiatica FSC147 spermidine synthase YP_001891362.1 647430 D 441952 CDS YP_001891363.1 187931379 6291705 648325..649734 1 NC_010677.1 putative arginine decarboxylase 649734 6291705 FTM_0587 Francisella tularensis subsp. mediasiatica FSC147 putative arginine decarboxylase YP_001891363.1 648325 D 441952 CDS YP_001891364.1 187931380 6291711 650944..651804 1 NC_010677.1 hydrolase, carbon-nitrogen family 651804 6291711 FTM_0589 Francisella tularensis subsp. mediasiatica FSC147 hydrolase, carbon-nitrogen family YP_001891364.1 650944 D 441952 CDS YP_001891365.1 187931381 6291713 complement(651821..652537) 1 NC_010677.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 652537 lpxH 6291713 lpxH Francisella tularensis subsp. mediasiatica FSC147 UDP-2,3-diacylglucosamine hydrolase YP_001891365.1 651821 R 441952 CDS YP_001891366.1 187931382 6291714 complement(652527..653153) 1 NC_010677.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 653153 pyrE 6291714 pyrE Francisella tularensis subsp. mediasiatica FSC147 orotate phosphoribosyltransferase YP_001891366.1 652527 R 441952 CDS YP_001891367.1 187931383 6291715 653313..654683 1 NC_010677.1 UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 654683 mpl 6291715 mpl Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_001891367.1 653313 D 441952 CDS YP_001891368.1 187931384 6290668 656238..656537 1 NC_010677.1 ArsR family transcriptional regulator 656537 6290668 FTM_0594 Francisella tularensis subsp. mediasiatica FSC147 ArsR family transcriptional regulator YP_001891368.1 656238 D 441952 CDS YP_001891369.1 187931385 6291572 658880..659566 1 NC_010677.1 Zn-dependent hydrolase 659566 6291572 FTM_0597 Francisella tularensis subsp. mediasiatica FSC147 Zn-dependent hydrolase YP_001891369.1 658880 D 441952 CDS YP_001891370.1 187931386 6291481 complement(660309..660929) 1 NC_010677.1 oxidoreductase 660929 6291481 FTM_0599 Francisella tularensis subsp. mediasiatica FSC147 oxidoreductase YP_001891370.1 660309 R 441952 CDS YP_001891371.1 187931387 6291647 complement(660969..661418) 1 NC_010677.1 hypothetical protein 661418 6291647 FTM_0600 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891371.1 660969 R 441952 CDS YP_001891372.1 187931388 6291595 complement(662165..662566) 1 NC_010677.1 hypothetical protein 662566 6291595 FTM_0602 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891372.1 662165 R 441952 CDS YP_001891373.1 187931389 6291627 662753..663178 1 NC_010677.1 transcription antitermination factor NusB 663178 nusB 6291627 nusB Francisella tularensis subsp. mediasiatica FSC147 transcription antitermination factor NusB YP_001891373.1 662753 D 441952 CDS YP_001891374.1 187931390 6291538 complement(663162..663932) 1 NC_010677.1 carbon-nitrogen hydrolase 663932 6291538 FTM_0604 Francisella tularensis subsp. mediasiatica FSC147 carbon-nitrogen hydrolase YP_001891374.1 663162 R 441952 CDS YP_001891375.1 187931391 6291525 664101..664514 1 NC_010677.1 lipoprotein 664514 6291525 FTM_0605 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891375.1 664101 D 441952 CDS YP_001891376.1 187931392 6291503 complement(666059..667192) 1 NC_010677.1 aspartate/tyrosine/aromatic aminotransferase 667192 6291503 FTM_0607 Francisella tularensis subsp. mediasiatica FSC147 aspartate/tyrosine/aromatic aminotransferase YP_001891376.1 666059 R 441952 CDS YP_001891377.1 187931393 6291487 complement(667338..669035) 1 NC_010677.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 669035 proS 6291487 proS Francisella tularensis subsp. mediasiatica FSC147 prolyl-tRNA synthetase YP_001891377.1 667338 R 441952 CDS YP_001891378.1 187931394 6291494 complement(671064..671291) 1 NC_010677.1 hypothetical protein 671291 6291494 FTM_0609 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891378.1 671064 R 441952 CDS YP_001891379.1 187931395 6291479 complement(671623..672159) 1 NC_010677.1 disulfide bond formation protein, DsbB family 672159 6291479 FTM_0610 Francisella tularensis subsp. mediasiatica FSC147 disulfide bond formation protein, DsbB family YP_001891379.1 671623 R 441952 CDS YP_001891380.1 187931396 6291471 672866..673282 1 NC_010677.1 sulfur acceptor protein SufE 673282 sufE 6291471 sufE Francisella tularensis subsp. mediasiatica FSC147 sulfur acceptor protein SufE YP_001891380.1 672866 D 441952 CDS YP_001891381.1 187931397 6291473 673283..674032 1 NC_010677.1 uroporphyrinogen III synthase 674032 6291473 FTM_0613 Francisella tularensis subsp. mediasiatica FSC147 uroporphyrinogen III synthase YP_001891381.1 673283 D 441952 CDS YP_001891382.1 187931398 6291442 673998..675083 1 NC_010677.1 membrane protein 675083 6291442 FTM_0614 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891382.1 673998 D 441952 CDS YP_001891383.1 187931399 6291446 675080..676237 1 NC_010677.1 membrane protein 676237 6291446 FTM_0615 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891383.1 675080 D 441952 CDS YP_001891384.1 187931400 6291422 676251..677009 1 NC_010677.1 hydroxyacylglutathione hydrolase 677009 gloB 6291422 gloB Francisella tularensis subsp. mediasiatica FSC147 hydroxyacylglutathione hydrolase YP_001891384.1 676251 D 441952 CDS YP_001891385.1 187931401 6291434 complement(677087..677794) 1 NC_010677.1 hypothetical protein 677794 6291434 FTM_0617 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891385.1 677087 R 441952 CDS YP_001891386.1 187931402 6291401 677903..678127 1 NC_010677.1 Fe2+ transport system protein A 678127 feoA 6291401 feoA Francisella tularensis subsp. mediasiatica FSC147 Fe2+ transport system protein A YP_001891386.1 677903 D 441952 CDS YP_001891387.1 187931403 6291403 678144..679778 1 NC_010677.1 hypothetical protein 679778 6291403 FTM_0619 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891387.1 678144 D 441952 CDS YP_001891388.1 187931404 6291356 complement(680350..681003) 1 NC_010677.1 prophage repressor protein 681003 6291356 FTM_0623 Francisella tularensis subsp. mediasiatica FSC147 prophage repressor protein YP_001891388.1 680350 R 441952 CDS YP_001891389.1 187931405 6291322 681172..681558 1 NC_010677.1 hypothetical protein 681558 6291322 FTM_0624 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891389.1 681172 D 441952 CDS YP_001891390.1 187931406 6291335 complement(681572..682441) 1 NC_010677.1 drug/metabolite exporter 682441 6291335 FTM_0625 Francisella tularensis subsp. mediasiatica FSC147 drug/metabolite exporter YP_001891390.1 681572 R 441952 CDS YP_001891391.1 187931407 6291295 682618..684204 1 NC_010677.1 glutamate synthase domain 2 684204 gltB 6291295 gltB Francisella tularensis subsp. mediasiatica FSC147 glutamate synthase domain 2 YP_001891391.1 682618 D 441952 CDS YP_001891392.1 187931408 6291297 684281..687520 1 NC_010677.1 exodeoxyribonuclease V subunit gamma 687520 recC 6291297 recC Francisella tularensis subsp. mediasiatica FSC147 exodeoxyribonuclease V subunit gamma YP_001891392.1 684281 D 441952 CDS YP_001891393.1 187931409 6291263 687462..688034 1 NC_010677.1 hypothetical protein 688034 6291263 FTM_0628 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891393.1 687462 D 441952 CDS YP_001891394.1 187931410 6291712 688177..689565 1 NC_010677.1 ATP-dependent DNA helicase 689565 6291712 FTM_0629 Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent DNA helicase YP_001891394.1 688177 D 441952 CDS YP_001891395.1 187931411 6291707 689637..693290 1 NC_010677.1 exodeoxyribonuclease V subunit beta 693290 recB 6291707 recB Francisella tularensis subsp. mediasiatica FSC147 exodeoxyribonuclease V subunit beta YP_001891395.1 689637 D 441952 CDS YP_001891396.1 187931412 6290108 693256..695124 1 NC_010677.1 exodeoxyribonuclease V subunit alpha 695124 recD 6290108 recD Francisella tularensis subsp. mediasiatica FSC147 exodeoxyribonuclease V subunit alpha YP_001891396.1 693256 D 441952 CDS YP_001891397.1 187931413 6291244 complement(695133..695903) 1 NC_010677.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 695903 6291244 FTM_0632 Francisella tularensis subsp. mediasiatica FSC147 pantothenate kinase YP_001891397.1 695133 R 441952 CDS YP_001891398.1 187931414 6291250 complement(695907..696242) 1 NC_010677.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 696242 panD 6291250 panD Francisella tularensis subsp. mediasiatica FSC147 aspartate alpha-decarboxylase YP_001891398.1 695907 R 441952 CDS YP_001891399.1 187931415 6291213 complement(696236..697021) 1 NC_010677.1 pantoate-beta-alanine ligase 697021 panC 6291213 panC Francisella tularensis subsp. mediasiatica FSC147 pantoate-beta-alanine ligase YP_001891399.1 696236 R 441952 CDS YP_001891400.1 187931416 6291217 complement(697008..697805) 1 NC_010677.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 697805 panB 6291217 panB Francisella tularensis subsp. mediasiatica FSC147 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_001891400.1 697008 R 441952 CDS YP_001891401.1 187931417 6291208 complement(697807..698523) 1 NC_010677.1 hypothetical protein 698523 6291208 FTM_0636 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891401.1 697807 R 441952 CDS YP_001891402.1 187931418 6291189 698831..700867 1 NC_010677.1 NAD-dependent DNA ligase 700867 ligA 6291189 ligA Francisella tularensis subsp. mediasiatica FSC147 NAD-dependent DNA ligase YP_001891402.1 698831 D 441952 CDS YP_001891403.1 187931419 6291020 702322..702813 1 NC_010677.1 acetyltransferase 702813 6291020 FTM_0639 Francisella tularensis subsp. mediasiatica FSC147 acetyltransferase YP_001891403.1 702322 D 441952 CDS YP_001891404.1 187931420 6291185 complement(702791..704071) 1 NC_010677.1 tRNA and rRNA cytosine-C5-methylase, sun protein 704071 sun 6291185 sun Francisella tularensis subsp. mediasiatica FSC147 tRNA and rRNA cytosine-C5-methylase, sun protein YP_001891404.1 702791 R 441952 CDS YP_001891405.1 187931421 6291164 complement(704071..704859) 1 NC_010677.1 inositol-1-monophosphatase 704859 6291164 FTM_0641 Francisella tularensis subsp. mediasiatica FSC147 inositol-1-monophosphatase YP_001891405.1 704071 R 441952 CDS YP_001891406.1 187931422 6291155 complement(705884..707083) 1 NC_010677.1 hypothetical protein 707083 6291155 FTM_0643 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891406.1 705884 R 441952 CDS YP_001891407.1 187931423 6291159 707205..707891 1 NC_010677.1 hypothetical protein 707891 6291159 FTM_0644 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891407.1 707205 D 441952 CDS YP_001891408.1 187931424 6291140 complement(707881..708165) 1 NC_010677.1 hypothetical protein 708165 6291140 FTM_0645 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891408.1 707881 R 441952 CDS YP_001891409.1 187931425 6291150 complement(708245..709504) 1 NC_010677.1 beta-ketoacyl-ACP synthase II 709504 fabF 6291150 fabF Francisella tularensis subsp. mediasiatica FSC147 beta-ketoacyl-ACP synthase II YP_001891409.1 708245 R 441952 CDS YP_001891410.1 187931426 6291101 complement(709584..709868) 1 NC_010677.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 709868 acpP 6291101 acpP Francisella tularensis subsp. mediasiatica FSC147 acyl carrier protein YP_001891410.1 709584 R 441952 CDS YP_001891411.1 187931427 6291093 complement(709964..710707) 1 NC_010677.1 beta-ketoacyl-ACP reductase 710707 fabG 6291093 fabG Francisella tularensis subsp. mediasiatica FSC147 beta-ketoacyl-ACP reductase YP_001891411.1 709964 R 441952 CDS YP_001891412.1 187931428 6291078 complement(710721..711641) 1 NC_010677.1 malonyl-CoA:ACP transacylase 711641 fabD 6291078 fabD Francisella tularensis subsp. mediasiatica FSC147 malonyl-CoA:ACP transacylase YP_001891412.1 710721 R 441952 CDS YP_001891413.1 187931429 6291059 complement(711689..712660) 1 NC_010677.1 3-oxoacyl-ACP synthase 712660 fabH 6291059 fabH Francisella tularensis subsp. mediasiatica FSC147 3-oxoacyl-ACP synthase YP_001891413.1 711689 R 441952 CDS YP_001891414.1 187931430 6291068 complement(712757..713803) 1 NC_010677.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 713803 plsX 6291068 plsX Francisella tularensis subsp. mediasiatica FSC147 putative glycerol-3-phosphate acyltransferase PlsX YP_001891414.1 712757 R 441952 CDS YP_001891415.1 187931431 6291048 complement(713902..714084) 1 NC_010677.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 714084 rpmF 6291048 rpmF Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L32 YP_001891415.1 713902 R 441952 CDS YP_001891416.1 187931432 6291050 complement(714128..714631) 1 NC_010677.1 hypothetical protein 714631 6291050 FTM_0653 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891416.1 714128 R 441952 CDS YP_001891417.1 187931433 6291029 714771..717800 1 NC_010677.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 717800 6291029 FTM_0654 Francisella tularensis subsp. mediasiatica FSC147 transketolase YP_001891417.1 714771 D 441952 CDS YP_001891418.1 187931434 6291083 717819..718997 1 NC_010677.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 718997 pgk 6291083 pgk Francisella tularensis subsp. mediasiatica FSC147 phosphoglycerate kinase YP_001891418.1 717819 D 441952 CDS YP_001891419.1 187931435 6291024 719013..720449 1 NC_010677.1 pyruvate kinase 720449 pyk 6291024 pyk Francisella tularensis subsp. mediasiatica FSC147 pyruvate kinase YP_001891419.1 719013 D 441952 CDS YP_001891420.1 187931436 6291033 720465..721529 1 NC_010677.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 721529 fbaA 6291033 fbaA Francisella tularensis subsp. mediasiatica FSC147 fructose-1,6-bisphosphate aldolase YP_001891420.1 720465 D 441952 CDS YP_001891421.1 187931437 6291008 724593..725714 1 NC_010677.1 ATP-binding cassette putrescine uptake system, ATP-binding protein 725714 potG 6291008 potG Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette putrescine uptake system, ATP-binding protein YP_001891421.1 724593 D 441952 CDS YP_001891422.1 187931438 6291010 725714..726595 1 NC_010677.1 ATP-binding cassette putrescine uptake system, membrane protein, subunit H 726595 potH 6291010 potH Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette putrescine uptake system, membrane protein, subunit H YP_001891422.1 725714 D 441952 CDS YP_001891423.1 187931439 6290996 726609..727415 1 NC_010677.1 ATP-binding cassette putrescine uptake system, membrane protein, subunit I 727415 potI 6290996 potI Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette putrescine uptake system, membrane protein, subunit I YP_001891423.1 726609 D 441952 CDS YP_001891424.1 187931440 6291006 728464..729741 1 NC_010677.1 3-phosphoshikimate 1-carboxyvinyltransferase 729741 aroA 6291006 aroA Francisella tularensis subsp. mediasiatica FSC147 3-phosphoshikimate 1-carboxyvinyltransferase YP_001891424.1 728464 D 441952 CDS YP_001891425.1 187931441 6290989 729744..730334 1 NC_010677.1 hypothetical protein 730334 6290989 FTM_0664 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891425.1 729744 D 441952 CDS YP_001891426.1 187931442 6290991 730309..730767 1 NC_010677.1 Ribonuclease H 730767 rnhA 6290991 rnhA Francisella tularensis subsp. mediasiatica FSC147 Ribonuclease H YP_001891426.1 730309 D 441952 CDS YP_001891427.1 187931443 6290981 730769..731806 1 NC_010677.1 L-asparaginase 1 731806 ansA 6290981 ansA Francisella tularensis subsp. mediasiatica FSC147 L-asparaginase 1 YP_001891427.1 730769 D 441952 CDS YP_001891428.1 187931444 6290956 731877..732563 1 NC_010677.1 carbonic anhydrase 732563 cynT 6290956 cynT Francisella tularensis subsp. mediasiatica FSC147 carbonic anhydrase YP_001891428.1 731877 D 441952 CDS YP_001891429.1 187931445 6291695 complement(732850..733455) 1 NC_010677.1 membrane protein 733455 6291695 FTM_0668 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891429.1 732850 R 441952 CDS YP_001891430.1 187931446 6290958 complement(733519..734391) 1 NC_010677.1 hypothetical protein 734391 6290958 FTM_0669 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891430.1 733519 R 441952 CDS YP_001891431.1 187931447 6290951 complement(734400..734570) 1 NC_010677.1 rubredoxin 734570 rubA 6290951 rubA Francisella tularensis subsp. mediasiatica FSC147 rubredoxin YP_001891431.1 734400 R 441952 CDS YP_001891432.1 187931448 6290955 complement(734657..735274) 1 NC_010677.1 hypothetical protein 735274 6290955 FTM_0671 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891432.1 734657 R 441952 CDS YP_001891433.1 187931449 6290939 735386..736777 1 NC_010677.1 hypothetical protein 736777 6290939 FTM_0672 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891433.1 735386 D 441952 CDS YP_001891434.1 187931450 6290947 complement(736809..738083) 1 NC_010677.1 dicarboxylate/amino acid:cation (Na+ or H+) symporter 738083 6290947 FTM_0673 Francisella tularensis subsp. mediasiatica FSC147 dicarboxylate/amino acid:cation (Na+ or H+) symporter YP_001891434.1 736809 R 441952 CDS YP_001891435.1 187931451 6290923 738285..739313 1 NC_010677.1 phosphosugar binding protein 739313 6290923 FTM_0674 Francisella tularensis subsp. mediasiatica FSC147 phosphosugar binding protein YP_001891435.1 738285 D 441952 CDS YP_001891436.1 187931452 6290931 739338..740741 1 NC_010677.1 MFS family major facilitator transporter 740741 6290931 FTM_0675 Francisella tularensis subsp. mediasiatica FSC147 MFS family major facilitator transporter YP_001891436.1 739338 D 441952 CDS YP_001891437.1 187931453 6290919 740895..741014 1 NC_010677.1 hypothetical protein 741014 6290919 FTM_0676 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891437.1 740895 D 441952 CDS YP_001891438.1 187931454 6290914 741128..741436 1 NC_010677.1 IS1 transposase 741436 6290914 FTM_0677 Francisella tularensis subsp. mediasiatica FSC147 IS1 transposase YP_001891438.1 741128 D 441952 CDS YP_001891439.1 187931455 6290891 743655..743834 1 NC_010677.1 hypothetical protein 743834 6290891 FTM_0679 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891439.1 743655 D 441952 CDS YP_001891440.1 187931456 6291147 745851..747068 1 NC_010677.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 747068 ispG 6291147 ispG Francisella tularensis subsp. mediasiatica FSC147 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001891440.1 745851 D 441952 CDS YP_001891441.1 187931457 6291099 747083..747790 1 NC_010677.1 hypothetical protein 747790 6291099 FTM_0683 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891441.1 747083 D 441952 CDS YP_001891442.1 187931458 6291326 747809..749602 1 NC_010677.1 X-prolyl aminopeptidase 2 749602 6291326 FTM_0684 Francisella tularensis subsp. mediasiatica FSC147 X-prolyl aminopeptidase 2 YP_001891442.1 747809 D 441952 CDS YP_001891443.1 187931459 6291052 749700..750764 1 NC_010677.1 DNA/RNA endonuclease G 750764 6291052 FTM_0685 Francisella tularensis subsp. mediasiatica FSC147 DNA/RNA endonuclease G YP_001891443.1 749700 D 441952 CDS YP_001891444.1 187931460 6291689 complement(750755..751618) 1 NC_010677.1 beta-lactamase class A 751618 6291689 FTM_0686 Francisella tularensis subsp. mediasiatica FSC147 beta-lactamase class A YP_001891444.1 750755 R 441952 CDS YP_001891445.1 187931461 6291292 complement(753187..753606) 1 NC_010677.1 hypothetical protein 753606 6291292 FTM_0688 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891445.1 753187 R 441952 CDS YP_001891446.1 187931462 6291704 complement(753852..755342) 1 NC_010677.1 apolipoprotein N-acyltransferase 755342 lnt 6291704 lnt Francisella tularensis subsp. mediasiatica FSC147 apolipoprotein N-acyltransferase YP_001891446.1 753852 R 441952 CDS YP_001891447.1 187931463 6291448 complement(755342..756184) 1 NC_010677.1 transporter-associated protein, HlyC/CorC family 756184 6291448 FTM_0690 Francisella tularensis subsp. mediasiatica FSC147 transporter-associated protein, HlyC/CorC family YP_001891447.1 755342 R 441952 CDS YP_001891448.1 187931464 6290924 complement(756174..756662) 1 NC_010677.1 hypothetical protein 756662 6290924 FTM_0691 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891448.1 756174 R 441952 CDS YP_001891449.1 187931465 6291002 complement(756655..757638) 1 NC_010677.1 PhoH family protein ATPase 757638 6291002 FTM_0692 Francisella tularensis subsp. mediasiatica FSC147 PhoH family protein ATPase YP_001891449.1 756655 R 441952 CDS YP_001891450.1 187931466 6291686 complement(757642..758970) 1 NC_010677.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 758970 miaB 6291686 miaB Francisella tularensis subsp. mediasiatica FSC147 (dimethylallyl)adenosine tRNA methylthiotransferase YP_001891450.1 757642 R 441952 CDS YP_001891451.1 187931467 6291567 759193..759867 1 NC_010677.1 O-methyltransferase family protein 759867 6291567 FTM_0694 Francisella tularensis subsp. mediasiatica FSC147 O-methyltransferase family protein YP_001891451.1 759193 D 441952 CDS YP_001891452.1 187931468 6291454 760619..761212 1 NC_010677.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 761212 tdk 6291454 tdk Francisella tularensis subsp. mediasiatica FSC147 thymidine kinase YP_001891452.1 760619 D 441952 CDS YP_001891453.1 187931469 6291620 complement(761255..761719) 1 NC_010677.1 membrane protein 761719 6291620 FTM_0697 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891453.1 761255 R 441952 CDS YP_001891454.1 187931470 6291070 761874..763190 1 NC_010677.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 763190 tig 6291070 tig Francisella tularensis subsp. mediasiatica FSC147 trigger factor YP_001891454.1 761874 D 441952 CDS YP_001891455.1 187931471 6291510 763216..763821 1 NC_010677.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 763821 clpP 6291510 clpP Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent Clp protease proteolytic subunit YP_001891455.1 763216 D 441952 CDS YP_001891456.1 187931472 6291414 763845..765098 1 NC_010677.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 765098 clpX 6291414 clpX Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent protease ATP-binding subunit ClpX YP_001891456.1 763845 D 441952 CDS YP_001891457.1 187931473 6291571 765123..767447 1 NC_010677.1 ATP-dependent protease La 767447 lon 6291571 lon Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent protease La YP_001891457.1 765123 D 441952 CDS YP_001891458.1 187931474 6291413 767534..767806 1 NC_010677.1 DNA-binding protein HU-beta 767806 hupB 6291413 hupB Francisella tularensis subsp. mediasiatica FSC147 DNA-binding protein HU-beta YP_001891458.1 767534 D 441952 CDS YP_001891459.1 187931475 6291575 767920..769353 1 NC_010677.1 hypothetical protein 769353 6291575 FTM_0703 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891459.1 767920 D 441952 CDS YP_001891460.1 187931476 6291710 769354..770280 1 NC_010677.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 770280 miaA 6291710 miaA Francisella tularensis subsp. mediasiatica FSC147 tRNA delta(2)-isopentenylpyrophosphate transferase YP_001891460.1 769354 D 441952 CDS YP_001891461.1 187931477 6291457 770391..770720 1 NC_010677.1 host factor I for bacteriophage Q beta replication 770720 hfq 6291457 hfq Francisella tularensis subsp. mediasiatica FSC147 host factor I for bacteriophage Q beta replication YP_001891461.1 770391 D 441952 CDS YP_001891462.1 187931478 6291284 770769..772079 1 NC_010677.1 protease, GTP-binding subunit 772079 hflX 6291284 hflX Francisella tularensis subsp. mediasiatica FSC147 protease, GTP-binding subunit YP_001891462.1 770769 D 441952 CDS YP_001891463.1 187931479 6291552 complement(772090..773268) 1 NC_010677.1 hypothetical protein 773268 6291552 FTM_0707 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891463.1 772090 R 441952 CDS YP_001891464.1 187931480 6291521 773453..774520 1 NC_010677.1 HflK-HflC membrane protein complex, HflK 774520 hflK 6291521 hflK Francisella tularensis subsp. mediasiatica FSC147 HflK-HflC membrane protein complex, HflK YP_001891464.1 773453 D 441952 CDS YP_001891465.1 187931481 6291679 774522..775448 1 NC_010677.1 HflK-HflC membrane protein complex, HflC 775448 hflC 6291679 hflC Francisella tularensis subsp. mediasiatica FSC147 HflK-HflC membrane protein complex, HflC YP_001891465.1 774522 D 441952 CDS YP_001891466.1 187931482 6291452 775449..775934 1 NC_010677.1 low molecular weight (LMW) phosphotyrosine protein phosphatase 775934 wzb 6291452 wzb Francisella tularensis subsp. mediasiatica FSC147 low molecular weight (LMW) phosphotyrosine protein phosphatase YP_001891466.1 775449 D 441952 CDS YP_001891467.1 187931483 6289967 775931..776524 1 NC_010677.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 776524 engB 6289967 engB Francisella tularensis subsp. mediasiatica FSC147 ribosome biogenesis GTP-binding protein YsxC YP_001891467.1 775931 D 441952 CDS YP_001891468.1 187931484 6289968 complement(777577..778773) 1 NC_010677.1 ATPase 778773 6289968 FTM_0712 Francisella tularensis subsp. mediasiatica FSC147 ATPase YP_001891468.1 777577 R 441952 CDS YP_001891469.1 187931485 6289969 complement(778774..780009) 1 NC_010677.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 780009 serA 6289969 serA Francisella tularensis subsp. mediasiatica FSC147 D-3-phosphoglycerate dehydrogenase YP_001891469.1 778774 R 441952 CDS YP_001891470.1 187931486 6289970 complement(780021..780845) 1 NC_010677.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 780845 thyA 6289970 thyA Francisella tularensis subsp. mediasiatica FSC147 thymidylate synthase YP_001891470.1 780021 R 441952 CDS YP_001891471.1 187931487 6289972 complement(780830..781636) 1 NC_010677.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 781636 lgt 6289972 lgt Francisella tularensis subsp. mediasiatica FSC147 prolipoprotein diacylglyceryl transferase YP_001891471.1 780830 R 441952 CDS YP_001891472.1 187931488 6289973 complement(781651..784308) 1 NC_010677.1 ribonuclease E 784308 rne 6289973 rne Francisella tularensis subsp. mediasiatica FSC147 ribonuclease E YP_001891472.1 781651 R 441952 CDS YP_001891473.1 187931489 6289975 784558..785733 1 NC_010677.1 cysteine desulfurase 785733 iscS 6289975 iscS Francisella tularensis subsp. mediasiatica FSC147 cysteine desulfurase YP_001891473.1 784558 D 441952 CDS YP_001891474.1 187931490 6289976 785726..786055 1 NC_010677.1 hypothetical protein 786055 6289976 FTM_0718 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891474.1 785726 D 441952 CDS YP_001891475.1 187931491 6289977 786039..786737 1 NC_010677.1 RecFOR complex, RecO component 786737 recO 6289977 recO Francisella tularensis subsp. mediasiatica FSC147 RecFOR complex, RecO component YP_001891475.1 786039 D 441952 CDS YP_001891476.1 187931492 6289978 complement(786813..787460) 1 NC_010677.1 DedA family protein 787460 6289978 FTM_0720 Francisella tularensis subsp. mediasiatica FSC147 DedA family protein YP_001891476.1 786813 R 441952 CDS YP_001891477.1 187931493 6289979 complement(787516..788142) 1 NC_010677.1 DedA family protein 788142 6289979 FTM_0721 Francisella tularensis subsp. mediasiatica FSC147 DedA family protein YP_001891477.1 787516 R 441952 CDS YP_001891478.1 187931494 6289980 complement(788149..788415) 1 NC_010677.1 BolA family protein 788415 6289980 FTM_0722 Francisella tularensis subsp. mediasiatica FSC147 BolA family protein YP_001891478.1 788149 R 441952 CDS YP_001891479.1 187931495 6289981 complement(788418..788966) 1 NC_010677.1 5-formyltetrahydrofolate cyclo-ligase 788966 6289981 FTM_0723 Francisella tularensis subsp. mediasiatica FSC147 5-formyltetrahydrofolate cyclo-ligase YP_001891479.1 788418 R 441952 CDS YP_001891480.1 187931496 6289982 789292..789942 1 NC_010677.1 hypothetical protein 789942 6289982 FTM_0724 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891480.1 789292 D 441952 CDS YP_001891481.1 187931497 6289984 789951..791162 1 NC_010677.1 2-octaprenyl-6-methoxyphenyl hydroxylase 791162 ubiH 6289984 ubiH Francisella tularensis subsp. mediasiatica FSC147 2-octaprenyl-6-methoxyphenyl hydroxylase YP_001891481.1 789951 D 441952 CDS YP_001891482.1 187931498 6289985 791152..792387 1 NC_010677.1 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 792387 6289985 FTM_0726 Francisella tularensis subsp. mediasiatica FSC147 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_001891482.1 791152 D 441952 CDS YP_001891483.1 187931499 6289987 792409..792870 1 NC_010677.1 hypothetical protein 792870 6289987 FTM_0727 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891483.1 792409 D 441952 CDS YP_001891484.1 187931500 6289988 792896..793912 1 NC_010677.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 793912 queA 6289988 queA Francisella tularensis subsp. mediasiatica FSC147 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_001891484.1 792896 D 441952 CDS YP_001891485.1 187931501 6289990 794548..795339 1 NC_010677.1 haloacid dehalogenase-like hydrolase 795339 6289990 FTM_0729 Francisella tularensis subsp. mediasiatica FSC147 haloacid dehalogenase-like hydrolase YP_001891485.1 794548 D 441952 CDS YP_001891486.1 187931502 6289991 complement(795593..796378) 1 NC_010677.1 hypothetical protein 796378 6289991 FTM_0730 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891486.1 795593 R 441952 CDS YP_001891487.1 187931503 6289994 798640..798828 1 NC_010677.1 hypothetical protein 798828 6289994 FTM_0733 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891487.1 798640 D 441952 CDS YP_001891488.1 187931504 6289995 798821..799573 1 NC_010677.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 799573 kdsB 6289995 kdsB Francisella tularensis subsp. mediasiatica FSC147 3-deoxy-manno-octulosonate cytidylyltransferase YP_001891488.1 798821 D 441952 CDS YP_001891489.1 187931505 6289996 799566..799961 1 NC_010677.1 HIT family protein 799961 6289996 FTM_0735 Francisella tularensis subsp. mediasiatica FSC147 HIT family protein YP_001891489.1 799566 D 441952 CDS YP_001891490.1 187931506 6289997 complement(799958..801106) 1 NC_010677.1 galactokinase 801106 galK 6289997 galK Francisella tularensis subsp. mediasiatica FSC147 galactokinase YP_001891490.1 799958 R 441952 CDS YP_001891491.1 187931507 6289999 complement(801109..802134) 1 NC_010677.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 802134 galT 6289999 galT Francisella tularensis subsp. mediasiatica FSC147 galactose-1-phosphate uridylyltransferase YP_001891491.1 801109 R 441952 CDS YP_001891492.1 187931508 6290000 802225..803607 1 NC_010677.1 galactose-proton symporter 803607 galP1 6290000 galP1 Francisella tularensis subsp. mediasiatica FSC147 galactose-proton symporter YP_001891492.1 802225 D 441952 CDS YP_001891493.1 187931509 6290003 803639..805033 1 NC_010677.1 galactose-proton symporter 805033 galP2 6290003 galP2 Francisella tularensis subsp. mediasiatica FSC147 galactose-proton symporter YP_001891493.1 803639 D 441952 CDS YP_001891494.1 187931510 6290004 805128..805406 1 NC_010677.1 parvulin-like peptidyl-prolyl isomerase domain 805406 ppiC 6290004 ppiC Francisella tularensis subsp. mediasiatica FSC147 parvulin-like peptidyl-prolyl isomerase domain YP_001891494.1 805128 D 441952 CDS YP_001891495.1 187931511 6290005 805471..807180 1 NC_010677.1 DEAD/DEAH box helicase 807180 deaD 6290005 deaD Francisella tularensis subsp. mediasiatica FSC147 DEAD/DEAH box helicase YP_001891495.1 805471 D 441952 CDS YP_001891496.1 187931512 6290006 807297..807869 1 NC_010677.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 807869 gmk 6290006 gmk Francisella tularensis subsp. mediasiatica FSC147 guanylate kinase YP_001891496.1 807297 D 441952 CDS YP_001891497.1 187931513 6290008 807890..808915 1 NC_010677.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 808915 nadA 6290008 nadA Francisella tularensis subsp. mediasiatica FSC147 quinolinate synthetase YP_001891497.1 807890 D 441952 CDS YP_001891498.1 187931514 6290010 808924..809784 1 NC_010677.1 nicotinate-nucleotide pyrophosphorylase 809784 nadC 6290010 nadC Francisella tularensis subsp. mediasiatica FSC147 nicotinate-nucleotide pyrophosphorylase YP_001891498.1 808924 D 441952 CDS YP_001891499.1 187931515 6290011 809787..811274 1 NC_010677.1 L-aspartate oxidase 811274 nadB 6290011 nadB Francisella tularensis subsp. mediasiatica FSC147 L-aspartate oxidase YP_001891499.1 809787 D 441952 CDS YP_001891500.1 187931516 6290014 813968..814258 1 NC_010677.1 hypothetical protein 814258 6290014 FTM_0748 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891500.1 813968 D 441952 CDS YP_001891501.1 187931517 6290015 814287..814757 1 NC_010677.1 glutathione peroxidase 814757 6290015 FTM_0749 Francisella tularensis subsp. mediasiatica FSC147 glutathione peroxidase YP_001891501.1 814287 D 441952 CDS YP_001891502.1 187931518 6290018 817045..817692 1 NC_010677.1 hypothetical protein 817692 6290018 FTM_0752 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891502.1 817045 D 441952 CDS YP_001891503.1 187931519 6290020 complement(817703..817831) 1 NC_010677.1 membrane protein 817831 6290020 FTM_0753 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891503.1 817703 R 441952 CDS YP_001891504.1 187931520 6290022 817999..819492 1 NC_010677.1 carbohydrate kinase family protein 819492 6290022 FTM_0754 Francisella tularensis subsp. mediasiatica FSC147 carbohydrate kinase family protein YP_001891504.1 817999 D 441952 CDS YP_001891505.1 187931521 6290023 complement(819527..819895) 1 NC_010677.1 heat shock protein 15 819895 6290023 FTM_0755 Francisella tularensis subsp. mediasiatica FSC147 heat shock protein 15 YP_001891505.1 819527 R 441952 CDS YP_001891506.1 187931522 6290027 825643..826458 1 NC_010677.1 hypothetical protein 826458 6290027 FTM_0758 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891506.1 825643 D 441952 CDS YP_001891507.1 187931523 6290029 complement(828252..829097) 1 NC_010677.1 auxiliary transport protein 829097 6290029 FTM_0760 Francisella tularensis subsp. mediasiatica FSC147 auxiliary transport protein YP_001891507.1 828252 R 441952 CDS YP_001891508.1 187931524 6290030 complement(829099..829302) 1 NC_010677.1 hypothetical protein 829302 6290030 FTM_0761 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891508.1 829099 R 441952 CDS YP_001891509.1 187931525 6290033 829499..830218 1 NC_010677.1 transcriptional regulator, IclR family 830218 6290033 FTM_0762 Francisella tularensis subsp. mediasiatica FSC147 transcriptional regulator, IclR family YP_001891509.1 829499 D 441952 CDS YP_001891510.1 187931526 6290035 complement(831312..831428) 1 NC_010677.1 hypothetical protein 831428 6290035 FTM_0764 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891510.1 831312 R 441952 CDS YP_001891511.1 187931527 6290036 831467..832453 1 NC_010677.1 aminomutase 832453 6290036 FTM_0765 Francisella tularensis subsp. mediasiatica FSC147 aminomutase YP_001891511.1 831467 D 441952 CDS YP_001891512.1 187931528 6290041 complement(832524..832727) 1 NC_010677.1 cold shock protein, DNA-binding 832727 cspA 6290041 cspA Francisella tularensis subsp. mediasiatica FSC147 cold shock protein, DNA-binding YP_001891512.1 832524 R 441952 CDS YP_001891513.1 187931529 6290042 complement(832926..833210) 1 NC_010677.1 hypothetical protein 833210 6290042 FTM_0767 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891513.1 832926 R 441952 CDS YP_001891514.1 187931530 6290043 833500..833700 1 NC_010677.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 833700 rpsU 6290043 rpsU Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S21 YP_001891514.1 833500 D 441952 CDS YP_001891515.1 187931531 6290049 835219..836358 1 NC_010677.1 Co/Zn/Cd cation transporter 836358 6290049 FTM_0771 Francisella tularensis subsp. mediasiatica FSC147 Co/Zn/Cd cation transporter YP_001891515.1 835219 D 441952 CDS YP_001891516.1 187931532 6290050 836375..837238 1 NC_010677.1 UTP-glucose-1-phosphate uridylyltransferase 837238 galU 6290050 galU Francisella tularensis subsp. mediasiatica FSC147 UTP-glucose-1-phosphate uridylyltransferase YP_001891516.1 836375 D 441952 CDS YP_001891517.1 187931533 6290053 838711..839628 1 NC_010677.1 integral membrane protein 839628 6290053 FTM_0774 Francisella tularensis subsp. mediasiatica FSC147 integral membrane protein YP_001891517.1 838711 D 441952 CDS YP_001891518.1 187931534 6290056 complement(839631..839837) 1 NC_010677.1 lipoprotein 839837 6290056 FTM_0775 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891518.1 839631 R 441952 CDS YP_001891519.1 187931535 6290059 complement(839922..840215) 1 NC_010677.1 hypothetical protein 840215 6290059 FTM_0776 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891519.1 839922 R 441952 CDS YP_001891520.1 187931536 6290061 complement(840237..841286) 1 NC_010677.1 RecFOR complex, RecF component 841286 recF 6290061 recF Francisella tularensis subsp. mediasiatica FSC147 RecFOR complex, RecF component YP_001891520.1 840237 R 441952 CDS YP_001891521.1 187931537 6290063 complement(841290..842036) 1 NC_010677.1 Mg-dependent DNase 842036 6290063 FTM_0778 Francisella tularensis subsp. mediasiatica FSC147 Mg-dependent DNase YP_001891521.1 841290 R 441952 CDS YP_001891522.1 187931538 6290064 842229..844313 1 NC_010677.1 glycyl-tRNA synthetase subunit beta 844313 glyS 6290064 glyS Francisella tularensis subsp. mediasiatica FSC147 glycyl-tRNA synthetase subunit beta YP_001891522.1 842229 D 441952 CDS YP_001891523.1 187931539 6290067 complement(847186..847860) 1 NC_010677.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 847860 rpiA 6290067 rpiA Francisella tularensis subsp. mediasiatica FSC147 ribose-5-phosphate isomerase A YP_001891523.1 847186 R 441952 CDS YP_001891524.1 187931540 6290070 complement(847862..849232) 1 NC_010677.1 membrane protein 849232 6290070 FTM_0782 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891524.1 847862 R 441952 CDS YP_001891525.1 187931541 6290071 complement(849246..849638) 1 NC_010677.1 lipoprotein 849638 6290071 FTM_0783 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891525.1 849246 R 441952 CDS YP_001891526.1 187931542 6290072 complement(849650..851533) 1 NC_010677.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 851533 gidA 6290072 gidA Francisella tularensis subsp. mediasiatica FSC147 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_001891526.1 849650 R 441952 CDS YP_001891527.1 187931543 6290074 851676..852758 1 NC_010677.1 membrane protein 852758 6290074 FTM_0785 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891527.1 851676 D 441952 CDS YP_001891528.1 187931544 6290075 852745..853650 1 NC_010677.1 membrane protein 853650 6290075 FTM_0786 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891528.1 852745 D 441952 CDS YP_001891529.1 187931545 6290077 complement(853661..854560) 1 NC_010677.1 transcriptional regulator, LysR family 854560 6290077 FTM_0787 Francisella tularensis subsp. mediasiatica FSC147 transcriptional regulator, LysR family YP_001891529.1 853661 R 441952 CDS YP_001891530.1 187931546 6290078 854676..855398 1 NC_010677.1 oxidoreductase, short-chain dehydrogenase family protein 855398 6290078 FTM_0788 Francisella tularensis subsp. mediasiatica FSC147 oxidoreductase, short-chain dehydrogenase family protein YP_001891530.1 854676 D 441952 CDS YP_001891531.1 187931547 6290080 855532..856980 1 NC_010677.1 exodeoxyribonuclease I 856980 sbcB 6290080 sbcB Francisella tularensis subsp. mediasiatica FSC147 exodeoxyribonuclease I YP_001891531.1 855532 D 441952 CDS YP_001891532.1 187931548 6290083 856982..858988 1 NC_010677.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 858988 uvrB 6290083 uvrB Francisella tularensis subsp. mediasiatica FSC147 excinuclease ABC subunit B YP_001891532.1 856982 D 441952 CDS YP_001891533.1 187931549 6290087 859025..859822 1 NC_010677.1 membrane protein 859822 6290087 FTM_0791 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891533.1 859025 D 441952 CDS YP_001891534.1 187931550 6290089 859822..860619 1 NC_010677.1 glutamate racemase 860619 murI 6290089 murI Francisella tularensis subsp. mediasiatica FSC147 glutamate racemase YP_001891534.1 859822 D 441952 CDS YP_001891535.1 187931551 6290092 860710..861987 1 NC_010677.1 metabolite:H+ symporter (MHS) family protein 861987 6290092 FTM_0793 Francisella tularensis subsp. mediasiatica FSC147 metabolite:H+ symporter (MHS) family protein YP_001891535.1 860710 D 441952 CDS YP_001891536.1 187931552 6290094 863660..864586 1 NC_010677.1 hypothetical protein 864586 6290094 FTM_0795 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891536.1 863660 D 441952 CDS YP_001891537.1 187931553 6290103 867716..869101 1 NC_010677.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 869101 xseA 6290103 xseA Francisella tularensis subsp. mediasiatica FSC147 exodeoxyribonuclease VII large subunit YP_001891537.1 867716 D 441952 CDS YP_001891538.1 187931554 6290104 869085..869285 1 NC_010677.1 hypothetical protein 869285 6290104 FTM_0799 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891538.1 869085 D 441952 CDS YP_001891539.1 187931555 6290107 complement(870894..871529) 1 NC_010677.1 membrane protein 871529 6290107 FTM_0801 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891539.1 870894 R 441952 CDS YP_001891540.1 187931556 6290112 complement(872546..873019) 1 NC_010677.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 873019 smpB 6290112 smpB Francisella tularensis subsp. mediasiatica FSC147 SsrA-binding protein YP_001891540.1 872546 R 441952 CDS YP_001891541.1 187931557 6290114 873094..873525 1 NC_010677.1 oligoketide cyclase/lipid transport protein 873525 6290114 FTM_0804 Francisella tularensis subsp. mediasiatica FSC147 oligoketide cyclase/lipid transport protein YP_001891541.1 873094 D 441952 CDS YP_001891542.1 187931558 6290116 873525..873830 1 NC_010677.1 hypothetical protein 873830 6290116 FTM_0805 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891542.1 873525 D 441952 CDS YP_001891543.1 187931559 6290117 873872..875077 1 NC_010677.1 hypothetical protein 875077 6290117 FTM_0806 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891543.1 873872 D 441952 CDS YP_001891544.1 187931560 6290118 875154..876074 1 NC_010677.1 VacJ like lipoprotein 876074 6290118 FTM_0807 Francisella tularensis subsp. mediasiatica FSC147 VacJ like lipoprotein YP_001891544.1 875154 D 441952 CDS YP_001891545.1 187931561 6290119 876129..877934 1 NC_010677.1 gamma-glutamyltranspeptidase 877934 ggt 6290119 ggt Francisella tularensis subsp. mediasiatica FSC147 gamma-glutamyltranspeptidase YP_001891545.1 876129 D 441952 CDS YP_001891546.1 187931562 6290121 complement(877950..878705) 1 NC_010677.1 methyltransferase 878705 6290121 FTM_0809 Francisella tularensis subsp. mediasiatica FSC147 methyltransferase YP_001891546.1 877950 R 441952 CDS YP_001891547.1 187931563 6290123 complement(878877..880694) 1 NC_010677.1 GTP binding translational elongation factor Tu and G family protein 880694 6290123 FTM_0810 Francisella tularensis subsp. mediasiatica FSC147 GTP binding translational elongation factor Tu and G family protein YP_001891547.1 878877 R 441952 CDS YP_001891548.1 187931564 6290127 885119..885283 1 NC_010677.1 membrane protein 885283 6290127 FTM_0813 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891548.1 885119 D 441952 CDS YP_001891549.1 187931565 6290128 885959..886168 1 NC_010677.1 hypothetical protein 886168 6290128 FTM_0814 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891549.1 885959 D 441952 CDS YP_001891550.1 187931566 6290132 888113..889561 1 NC_010677.1 type I restriction-modification system, M subunit 889561 6290132 FTM_0817 Francisella tularensis subsp. mediasiatica FSC147 type I restriction-modification system, M subunit YP_001891550.1 888113 D 441952 CDS YP_001891551.1 187931567 6290134 complement(889551..891296) 1 NC_010677.1 hypothetical protein 891296 6290134 FTM_0818 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891551.1 889551 R 441952 CDS YP_001891552.1 187931568 6290136 complement(891363..892235) 1 NC_010677.1 GTP-binding protein 892235 6290136 FTM_0819 Francisella tularensis subsp. mediasiatica FSC147 GTP-binding protein YP_001891552.1 891363 R 441952 CDS YP_001891553.1 187931569 6290137 892298..893431 1 NC_010677.1 N-acetylglucosamine-6-phosphate deacetylase 893431 nagA 6290137 nagA Francisella tularensis subsp. mediasiatica FSC147 N-acetylglucosamine-6-phosphate deacetylase YP_001891553.1 892298 D 441952 CDS YP_001891554.1 187931570 6290138 893435..894073 1 NC_010677.1 glycoprotease family protein 894073 6290138 FTM_0821 Francisella tularensis subsp. mediasiatica FSC147 glycoprotease family protein YP_001891554.1 893435 D 441952 CDS YP_001891555.1 187931571 6290143 894077..894883 1 NC_010677.1 glutamine amidotransferase 894883 6290143 FTM_0822 Francisella tularensis subsp. mediasiatica FSC147 glutamine amidotransferase YP_001891555.1 894077 D 441952 CDS YP_001891556.1 187931572 6290145 894893..896086 1 NC_010677.1 aspartate aminotransferase 896086 6290145 FTM_0823 Francisella tularensis subsp. mediasiatica FSC147 aspartate aminotransferase YP_001891556.1 894893 D 441952 CDS YP_001891557.1 187931573 6290147 896200..897093 1 NC_010677.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 897093 era 6290147 era Francisella tularensis subsp. mediasiatica FSC147 GTP-binding protein Era YP_001891557.1 896200 D 441952 CDS YP_001891558.1 187931574 6290149 897108..897524 1 NC_010677.1 membrane protein 897524 6290149 FTM_0825 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891558.1 897108 D 441952 CDS YP_001891559.1 187931575 6290152 complement(900861..901517) 1 NC_010677.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 901517 adk 6290152 adk Francisella tularensis subsp. mediasiatica FSC147 adenylate kinase YP_001891559.1 900861 R 441952 CDS YP_001891560.1 187931576 6290153 901644..902648 1 NC_010677.1 type IV pili, pilus assembly protein 902648 pilM 6290153 pilM Francisella tularensis subsp. mediasiatica FSC147 type IV pili, pilus assembly protein YP_001891560.1 901644 D 441952 CDS YP_001891561.1 187931577 6290154 902650..903213 1 NC_010677.1 type IV pili associated protein 903213 pilN 6290154 pilN Francisella tularensis subsp. mediasiatica FSC147 type IV pili associated protein YP_001891561.1 902650 D 441952 CDS YP_001891562.1 187931578 6290155 903207..903803 1 NC_010677.1 type IV pili glycosylation protein 903803 pilO 6290155 pilO Francisella tularensis subsp. mediasiatica FSC147 type IV pili glycosylation protein YP_001891562.1 903207 D 441952 CDS YP_001891563.1 187931579 6290158 903809..904399 1 NC_010677.1 Type IV pili periplasmic component 904399 pilP 6290158 pilP Francisella tularensis subsp. mediasiatica FSC147 Type IV pili periplasmic component YP_001891563.1 903809 D 441952 CDS YP_001891564.1 187931580 6290159 904412..906184 1 NC_010677.1 type IV pili secretin component 906184 pilQ 6290159 pilQ Francisella tularensis subsp. mediasiatica FSC147 type IV pili secretin component YP_001891564.1 904412 D 441952 CDS YP_001891565.1 187931581 6290164 906309..906839 1 NC_010677.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 906839 aroK 6290164 aroK Francisella tularensis subsp. mediasiatica FSC147 shikimate kinase I YP_001891565.1 906309 D 441952 CDS YP_001891566.1 187931582 6290167 906836..907915 1 NC_010677.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 907915 aroB 6290167 aroB Francisella tularensis subsp. mediasiatica FSC147 3-dehydroquinate synthase YP_001891566.1 906836 D 441952 CDS YP_001891567.1 187931583 6290168 907973..908197 1 NC_010677.1 hypothetical protein 908197 6290168 FTM_0835 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891567.1 907973 D 441952 CDS YP_001891568.1 187931584 6290169 complement(908264..908647) 1 NC_010677.1 hypothetical protein 908647 6290169 FTM_0836 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891568.1 908264 R 441952 CDS YP_001891569.1 187931585 6290171 908860..909147 1 NC_010677.1 hypothetical protein 909147 6290171 FTM_0837 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891569.1 908860 D 441952 CDS YP_001891570.1 187931586 6290172 909164..913228 1 NC_010677.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 913228 putA 6290172 putA Francisella tularensis subsp. mediasiatica FSC147 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_001891570.1 909164 D 441952 CDS YP_001891571.1 187931587 6290173 913388..914896 1 NC_010677.1 amino acid-polyamine-organocation (APC) superfamily 914896 6290173 FTM_0839 Francisella tularensis subsp. mediasiatica FSC147 amino acid-polyamine-organocation (APC) superfamily YP_001891571.1 913388 D 441952 CDS YP_001891572.1 187931588 6290174 914972..916156 1 NC_010677.1 major facilitator superfamily (MFS) transport protein 916156 6290174 FTM_0840 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily (MFS) transport protein YP_001891572.1 914972 D 441952 CDS YP_001891573.1 187931589 6290175 916169..917344 1 NC_010677.1 phosphopantothenoylcysteine decarboxylase/phosphopantothenate cysteine ligase 917344 dfp 6290175 dfp Francisella tularensis subsp. mediasiatica FSC147 phosphopantothenoylcysteine decarboxylase/phosphopantothenate cysteine ligase YP_001891573.1 916169 D 441952 CDS YP_001891574.1 187931590 6290177 complement(918397..918651) 1 NC_010677.1 hypothetical protein 918651 6290177 FTM_0843 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891574.1 918397 R 441952 CDS YP_001891575.1 187931591 6290180 complement(919693..919938) 1 NC_010677.1 hypothetical protein 919938 6290180 FTM_0845 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891575.1 919693 R 441952 CDS YP_001891576.1 187931592 6290187 923786..924592 1 NC_010677.1 ROK family protein 924592 6290187 FTM_0850 Francisella tularensis subsp. mediasiatica FSC147 ROK family protein YP_001891576.1 923786 D 441952 CDS YP_001891577.1 187931593 6290191 complement(925598..926275) 1 NC_010677.1 dethiobiotin synthase 926275 bioD 6290191 bioD Francisella tularensis subsp. mediasiatica FSC147 dethiobiotin synthase YP_001891577.1 925598 R 441952 CDS YP_001891578.1 187931594 6290192 complement(926279..927016) 1 NC_010677.1 biotin synthesis protein BioC 927016 bioC 6290192 bioC Francisella tularensis subsp. mediasiatica FSC147 biotin synthesis protein BioC YP_001891578.1 926279 R 441952 CDS YP_001891579.1 187931595 6290193 complement(926994..928121) 1 NC_010677.1 8-amino-7-oxononanoate synthase 928121 bioF 6290193 bioF Francisella tularensis subsp. mediasiatica FSC147 8-amino-7-oxononanoate synthase YP_001891579.1 926994 R 441952 CDS YP_001891580.1 187931596 6290195 complement(928115..929056) 1 NC_010677.1 biotin synthase 929056 bioB 6290195 bioB Francisella tularensis subsp. mediasiatica FSC147 biotin synthase YP_001891580.1 928115 R 441952 CDS YP_001891581.1 187931597 6290197 929103..930434 1 NC_010677.1 adenosylmethionine-8-amino-7-oxononanoate aminotransferase 930434 bioA 6290197 bioA Francisella tularensis subsp. mediasiatica FSC147 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_001891581.1 929103 D 441952 CDS YP_001891582.1 187931598 6290214 complement(935361..936614) 1 NC_010677.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 936614 glyA 6290214 glyA Francisella tularensis subsp. mediasiatica FSC147 serine hydroxymethyltransferase YP_001891582.1 935361 R 441952 CDS YP_001891583.1 187931599 6290215 936718..937266 1 NC_010677.1 hypothetical protein 937266 6290215 FTM_0861 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891583.1 936718 D 441952 CDS YP_001891584.1 187931600 6290219 complement(937281..938552) 1 NC_010677.1 membrane protein 938552 6290219 FTM_0862 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891584.1 937281 R 441952 CDS YP_001891585.1 187931601 6290220 938760..940091 1 NC_010677.1 membrane protein 940091 6290220 FTM_0863 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891585.1 938760 D 441952 CDS YP_001891586.1 187931602 6290226 complement(940117..941007) 1 NC_010677.1 glycosyl transferase family protein 941007 6290226 FTM_0864 Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family protein YP_001891586.1 940117 R 441952 CDS YP_001891587.1 187931603 6290227 complement(941015..942103) 1 NC_010677.1 hypothetical protein 942103 6290227 FTM_0865 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891587.1 941015 R 441952 CDS YP_001891588.1 187931604 6290230 942273..943337 1 NC_010677.1 glycosyl transferase family protein 943337 lpcC 6290230 lpcC Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family protein YP_001891588.1 942273 D 441952 CDS YP_001891589.1 187931605 6290235 complement(943338..944435) 1 NC_010677.1 choloylglycine hydrolase family protein 944435 6290235 FTM_0867 Francisella tularensis subsp. mediasiatica FSC147 choloylglycine hydrolase family protein YP_001891589.1 943338 R 441952 CDS YP_001891590.1 187931606 6290236 944682..946073 1 NC_010677.1 proton-dependent oligopeptide transporter disrupted by IS element 946073 6290236 FTM_0868 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter disrupted by IS element YP_001891590.1 944682 D 441952 CDS YP_001891591.1 187931607 6290251 946895..947407 1 NC_010677.1 hypothetical protein 947407 6290251 FTM_0869 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891591.1 946895 D 441952 CDS YP_001891592.1 187931608 6290257 complement(947565..948194) 1 NC_010677.1 hypothetical protein 948194 6290257 FTM_0870 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891592.1 947565 R 441952 CDS YP_001891593.1 187931609 6290263 948838..949344 1 NC_010677.1 hypothetical protein 949344 6290263 FTM_0871 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891593.1 948838 D 441952 CDS YP_001891594.1 187931610 6290267 952618..953418 1 NC_010677.1 hypothetical protein 953418 6290267 FTM_0873 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891594.1 952618 D 441952 CDS YP_001891595.1 187931611 6290273 954242..956899 1 NC_010677.1 type III restriction system endonuclease 956899 6290273 FTM_0875 Francisella tularensis subsp. mediasiatica FSC147 type III restriction system endonuclease YP_001891595.1 954242 D 441952 CDS YP_001891596.1 187931612 6290276 956918..957448 1 NC_010677.1 type III restriction enzyme, res subunit 957448 6290276 FTM_0876 Francisella tularensis subsp. mediasiatica FSC147 type III restriction enzyme, res subunit YP_001891596.1 956918 D 441952 CDS YP_001891597.1 187931613 6290278 957547..957888 1 NC_010677.1 hypothetical protein 957888 6290278 FTM_0877 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891597.1 957547 D 441952 CDS YP_001891598.1 187931614 6290282 959208..960071 1 NC_010677.1 hypothetical protein 960071 6290282 FTM_0878 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891598.1 959208 D 441952 CDS YP_001891599.1 187931615 6290285 961036..961590 1 NC_010677.1 fatty acid hydroxylase 961590 6290285 FTM_0880 Francisella tularensis subsp. mediasiatica FSC147 fatty acid hydroxylase YP_001891599.1 961036 D 441952 CDS YP_001891600.1 187931616 6290287 961665..963818 1 NC_010677.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 963818 rlmL 6290287 rlmL Francisella tularensis subsp. mediasiatica FSC147 23S rRNA m(2)G2445 methyltransferase YP_001891600.1 961665 D 441952 CDS YP_001891601.1 187931617 6290288 963920..964318 1 NC_010677.1 membrane protein 964318 6290288 FTM_0882 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891601.1 963920 D 441952 CDS YP_001891602.1 187931618 6290292 964323..965264 1 NC_010677.1 methionyl-tRNA formyltransferase 965264 fmt 6290292 fmt Francisella tularensis subsp. mediasiatica FSC147 methionyl-tRNA formyltransferase YP_001891602.1 964323 D 441952 CDS YP_001891603.1 187931619 6290294 965268..966242 1 NC_010677.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 966242 gshB 6290294 gshB Francisella tularensis subsp. mediasiatica FSC147 glutathione synthetase YP_001891603.1 965268 D 441952 CDS YP_001891604.1 187931620 6290311 966232..967527 1 NC_010677.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 967527 hemL 6290311 hemL Francisella tularensis subsp. mediasiatica FSC147 glutamate-1-semialdehyde aminotransferase YP_001891604.1 966232 D 441952 CDS YP_001891605.1 187931621 6290316 complement(967548..969215) 1 NC_010677.1 glycosyl hydrolase family protein 969215 6290316 FTM_0886 Francisella tularensis subsp. mediasiatica FSC147 glycosyl hydrolase family protein YP_001891605.1 967548 R 441952 CDS YP_001891606.1 187931622 6290322 complement(971461..972387) 1 NC_010677.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 972387 hemF 6290322 hemF Francisella tularensis subsp. mediasiatica FSC147 coproporphyrinogen III oxidase YP_001891606.1 971461 R 441952 CDS YP_001891607.1 187931623 6290326 973066..973401 1 NC_010677.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 973401 rpsF 6290326 rpsF Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S6 YP_001891607.1 973066 D 441952 CDS YP_001891608.1 187931624 6290327 973417..973635 1 NC_010677.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 973635 rpsR 6290327 rpsR Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S18 YP_001891608.1 973417 D 441952 CDS YP_001891609.1 187931625 6290335 973654..974109 1 NC_010677.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 974109 rplI 6290335 rplI Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L9 YP_001891609.1 973654 D 441952 CDS YP_001891610.1 187931626 6290341 974199..975596 1 NC_010677.1 replicative DNA helicase 975596 dnaB 6290341 dnaB Francisella tularensis subsp. mediasiatica FSC147 replicative DNA helicase YP_001891610.1 974199 D 441952 CDS YP_001891611.1 187931627 6290530 975627..976739 1 NC_010677.1 radical SAM protein 976739 6290530 FTM_0895 Francisella tularensis subsp. mediasiatica FSC147 radical SAM protein YP_001891611.1 975627 D 441952 CDS YP_001891612.1 187931628 6290345 976729..977634 1 NC_010677.1 Type IV pili, pilus assembly protein 977634 pilF 6290345 pilF Francisella tularensis subsp. mediasiatica FSC147 Type IV pili, pilus assembly protein YP_001891612.1 976729 D 441952 CDS YP_001891613.1 187931629 6290347 977627..978442 1 NC_010677.1 16S rRNA pseudouridine synthase 978442 rsuA 6290347 rsuA Francisella tularensis subsp. mediasiatica FSC147 16S rRNA pseudouridine synthase YP_001891613.1 977627 D 441952 CDS YP_001891614.1 187931630 6290348 978442..978867 1 NC_010677.1 hypothetical protein 978867 6290348 FTM_0898 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891614.1 978442 D 441952 CDS YP_001891615.1 187931631 6290351 978845..979285 1 NC_010677.1 ribosomal-protein-alanine acetyltransferase 979285 rimI 6290351 rimI Francisella tularensis subsp. mediasiatica FSC147 ribosomal-protein-alanine acetyltransferase YP_001891615.1 978845 D 441952 CDS YP_001891616.1 187931632 6290361 981726..981890 1 NC_010677.1 hypothetical protein 981890 6290361 FTM_0900 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891616.1 981726 D 441952 CDS YP_001891617.1 187931633 6290369 986432..987055 1 NC_010677.1 membrane protein 987055 6290369 FTM_0904 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891617.1 986432 D 441952 CDS YP_001891618.1 187931634 6290370 987136..987567 1 NC_010677.1 hypothetical protein 987567 6290370 FTM_0905 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891618.1 987136 D 441952 CDS YP_001891619.1 187931635 6290372 987657..988634 1 NC_010677.1 octaprenyl-diphosphate synthase 988634 ispB 6290372 ispB Francisella tularensis subsp. mediasiatica FSC147 octaprenyl-diphosphate synthase YP_001891619.1 987657 D 441952 CDS YP_001891620.1 187931636 6290382 complement(988652..989464) 1 NC_010677.1 fkbp-type peptidyl-prolyl cis-trans isomerase family protein 989464 6290382 FTM_0907 Francisella tularensis subsp. mediasiatica FSC147 fkbp-type peptidyl-prolyl cis-trans isomerase family protein YP_001891620.1 988652 R 441952 CDS YP_001891621.1 187931637 6290383 complement(989478..990281) 1 NC_010677.1 ATPase 990281 6290383 FTM_0908 Francisella tularensis subsp. mediasiatica FSC147 ATPase YP_001891621.1 989478 R 441952 CDS YP_001891622.1 187931638 6290385 complement(990274..990690) 1 NC_010677.1 thioesterase 990690 6290385 FTM_0909 Francisella tularensis subsp. mediasiatica FSC147 thioesterase YP_001891622.1 990274 R 441952 CDS YP_001891623.1 187931639 6290386 complement(990706..991317) 1 NC_010677.1 hypothetical protein 991317 6290386 FTM_0910 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891623.1 990706 R 441952 CDS YP_001891624.1 187931640 6290387 complement(991318..992721) 1 NC_010677.1 serine-type D-Ala-D-Ala carboxypeptidase 992721 6290387 FTM_0911 Francisella tularensis subsp. mediasiatica FSC147 serine-type D-Ala-D-Ala carboxypeptidase YP_001891624.1 991318 R 441952 CDS YP_001891625.1 187931641 6290389 992977..993165 1 NC_010677.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 993165 rpsU 6290389 rpsU Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S21 YP_001891625.1 992977 D 441952 CDS YP_001891626.1 187931642 6290390 993240..993686 1 NC_010677.1 GatB/YqeY domain-containing protein 993686 6290390 FTM_0913 Francisella tularensis subsp. mediasiatica FSC147 GatB/YqeY domain-containing protein YP_001891626.1 993240 D 441952 CDS YP_001891627.1 187931643 6290394 993707..995524 1 NC_010677.1 DNA primase 995524 dnaG 6290394 dnaG Francisella tularensis subsp. mediasiatica FSC147 DNA primase YP_001891627.1 993707 D 441952 CDS YP_001891628.1 187931644 6290395 995549..997282 1 NC_010677.1 RNA polymerase sigma-70 factor RpoD 997282 rpoD 6290395 rpoD Francisella tularensis subsp. mediasiatica FSC147 RNA polymerase sigma-70 factor RpoD YP_001891628.1 995549 D 441952 CDS YP_001891629.1 187931645 6290407 complement(1002746..1003366) 1 NC_010677.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1003366 lipB 6290407 lipB Francisella tularensis subsp. mediasiatica FSC147 lipoate-protein ligase B YP_001891629.1 1002746 R 441952 CDS YP_001891630.1 187931646 6290408 complement(1003376..1003660) 1 NC_010677.1 hypothetical protein 1003660 6290408 FTM_0920 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891630.1 1003376 R 441952 CDS YP_001891631.1 187931647 6290410 complement(1003693..1005027) 1 NC_010677.1 D-alanyl-D-alanine carboxypeptidase 1005027 6290410 FTM_0921 Francisella tularensis subsp. mediasiatica FSC147 D-alanyl-D-alanine carboxypeptidase YP_001891631.1 1003693 R 441952 CDS YP_001891632.1 187931648 6290411 1005184..1005705 1 NC_010677.1 inorganic pyrophosphatase 1005705 ppa 6290411 ppa Francisella tularensis subsp. mediasiatica FSC147 inorganic pyrophosphatase YP_001891632.1 1005184 D 441952 CDS YP_001891633.1 187931649 6290414 1005796..1006344 1 NC_010677.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 1006344 yrbI 6290414 yrbI Francisella tularensis subsp. mediasiatica FSC147 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_001891633.1 1005796 D 441952 CDS YP_001891634.1 187931650 6290415 1006352..1006978 1 NC_010677.1 hypothetical protein 1006978 6290415 FTM_0924 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891634.1 1006352 D 441952 CDS YP_001891635.1 187931651 6290416 1006965..1007795 1 NC_010677.1 hypothetical protein 1007795 6290416 FTM_0925 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891635.1 1006965 D 441952 CDS YP_001891636.1 187931652 6290419 1007869..1008600 1 NC_010677.1 ABC transporter ATP-binding protein 1008600 6290419 FTM_0926 Francisella tularensis subsp. mediasiatica FSC147 ABC transporter ATP-binding protein YP_001891636.1 1007869 D 441952 CDS YP_001891637.1 187931653 6290421 1008649..1009242 1 NC_010677.1 isomerase 1009242 6290421 FTM_0927 Francisella tularensis subsp. mediasiatica FSC147 isomerase YP_001891637.1 1008649 D 441952 CDS YP_001891638.1 187931654 6290423 1009255..1011087 1 NC_010677.1 hypothetical protein 1011087 6290423 FTM_0928 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891638.1 1009255 D 441952 CDS YP_001891639.1 187931655 6290424 1011090..1011866 1 NC_010677.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1011866 truA 6290424 truA Francisella tularensis subsp. mediasiatica FSC147 tRNA pseudouridine synthase A YP_001891639.1 1011090 D 441952 CDS YP_001891640.1 187931656 6290425 1011922..1013466 1 NC_010677.1 amino acid permease 1013466 6290425 FTM_0930 Francisella tularensis subsp. mediasiatica FSC147 amino acid permease YP_001891640.1 1011922 D 441952 CDS YP_001891641.1 187931657 6290426 1013554..1015104 1 NC_010677.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1015104 guaA 6290426 guaA Francisella tularensis subsp. mediasiatica FSC147 GMP synthase YP_001891641.1 1013554 D 441952 CDS YP_001891642.1 187931658 6290428 1015186..1017033 1 NC_010677.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1017033 dxs 6290428 dxs Francisella tularensis subsp. mediasiatica FSC147 1-deoxy-D-xylulose-5-phosphate synthase YP_001891642.1 1015186 D 441952 CDS YP_001891643.1 187931659 6290429 1017049..1017384 1 NC_010677.1 hypothetical protein 1017384 6290429 FTM_0933 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891643.1 1017049 D 441952 CDS YP_001891644.1 187931660 6290606 1017603..1018034 1 NC_010677.1 lipolytic enzyme, GDSL family 1018034 6290606 FTM_0934 Francisella tularensis subsp. mediasiatica FSC147 lipolytic enzyme, GDSL family YP_001891644.1 1017603 D 441952 CDS YP_001891645.1 187931661 6290435 complement(1018044..1018634) 1 NC_010677.1 hypothetical protein 1018634 6290435 FTM_0935 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891645.1 1018044 R 441952 CDS YP_001891646.1 187931662 6290437 1018752..1019477 1 NC_010677.1 short chain dehydrogenase family protein 1019477 6290437 FTM_0936 Francisella tularensis subsp. mediasiatica FSC147 short chain dehydrogenase family protein YP_001891646.1 1018752 D 441952 CDS YP_001891647.1 187931663 6290438 1019541..1020587 1 NC_010677.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1020587 ruvB 6290438 ruvB Francisella tularensis subsp. mediasiatica FSC147 Holliday junction DNA helicase RuvB YP_001891647.1 1019541 D 441952 CDS YP_001891648.1 187931664 6290439 complement(1020629..1021216) 1 NC_010677.1 peptidoglycan hydrolase 1021216 6290439 FTM_0938 Francisella tularensis subsp. mediasiatica FSC147 peptidoglycan hydrolase YP_001891648.1 1020629 R 441952 CDS YP_001891649.1 187931665 6290441 complement(1021562..1021750) 1 NC_010677.1 hypothetical protein 1021750 6290441 FTM_0939 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891649.1 1021562 R 441952 CDS YP_001891650.1 187931666 6290443 complement(1021862..1022065) 1 NC_010677.1 hypothetical protein 1022065 6290443 FTM_0940 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891650.1 1021862 R 441952 CDS YP_001891651.1 187931667 6290446 complement(1022080..1022616) 1 NC_010677.1 membrane protein 1022616 6290446 FTM_0941 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891651.1 1022080 R 441952 CDS YP_001891652.1 187931668 6290447 1022776..1023693 1 NC_010677.1 hypothetical protein 1023693 6290447 FTM_0942 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891652.1 1022776 D 441952 CDS YP_001891653.1 187931669 6290449 1025130..1026605 1 NC_010677.1 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 1026605 6290449 FTM_0944 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter YP_001891653.1 1025130 D 441952 CDS YP_001891654.1 187931670 6290453 1026630..1027523 1 NC_010677.1 drug/metabolite transporter superfamily protein 1027523 6290453 FTM_0945 Francisella tularensis subsp. mediasiatica FSC147 drug/metabolite transporter superfamily protein YP_001891654.1 1026630 D 441952 CDS YP_001891655.1 187931671 6290457 1027609..1028622 1 NC_010677.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1028622 pheS 6290457 pheS Francisella tularensis subsp. mediasiatica FSC147 phenylalanyl-tRNA synthetase subunit alpha YP_001891655.1 1027609 D 441952 CDS YP_001891656.1 187931672 6290460 1028643..1031015 1 NC_010677.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1031015 pheT 6290460 pheT Francisella tularensis subsp. mediasiatica FSC147 phenylalanyl-tRNA synthetase subunit beta YP_001891656.1 1028643 D 441952 CDS YP_001891657.1 187931673 6290462 complement(1031058..1031489) 1 NC_010677.1 Fe2+/Zn2+ uptake regulator protein 1031489 6290462 FTM_0948 Francisella tularensis subsp. mediasiatica FSC147 Fe2+/Zn2+ uptake regulator protein YP_001891657.1 1031058 R 441952 CDS YP_001891658.1 187931674 6290464 1031631..1032848 1 NC_010677.1 hypothetical protein 1032848 6290464 FTM_0949 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891658.1 1031631 D 441952 CDS YP_001891659.1 187931675 6290466 1032851..1033597 1 NC_010677.1 zinc (Zn2+)-iron (Fe2+) permease (ZIP) family protein 1033597 6290466 FTM_0950 Francisella tularensis subsp. mediasiatica FSC147 zinc (Zn2+)-iron (Fe2+) permease (ZIP) family protein YP_001891659.1 1032851 D 441952 CDS YP_001891660.1 187931676 6290472 complement(1033619..1034608) 1 NC_010677.1 lipoprotein 1034608 6290472 FTM_0951 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891660.1 1033619 R 441952 CDS YP_001891661.1 187931677 6290474 complement(1034777..1036207) 1 NC_010677.1 cardiolipin synthetase 1036207 cls 6290474 cls Francisella tularensis subsp. mediasiatica FSC147 cardiolipin synthetase YP_001891661.1 1034777 R 441952 CDS YP_001891662.1 187931678 6290481 1039091..1039951 1 NC_010677.1 Mrp-like protein 1039951 6290481 FTM_0955 Francisella tularensis subsp. mediasiatica FSC147 Mrp-like protein YP_001891662.1 1039091 D 441952 CDS YP_001891663.1 187931679 6290482 1039963..1040529 1 NC_010677.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1040529 dcd 6290482 dcd Francisella tularensis subsp. mediasiatica FSC147 deoxycytidine triphosphate deaminase YP_001891663.1 1039963 D 441952 CDS YP_001891664.1 187931680 6290483 complement(1040536..1041726) 1 NC_010677.1 small conductance mechanosensitive ion channel (MscS) family protein 1041726 6290483 FTM_0957 Francisella tularensis subsp. mediasiatica FSC147 small conductance mechanosensitive ion channel (MscS) family protein YP_001891664.1 1040536 R 441952 CDS YP_001891665.1 187931681 6290484 complement(1041786..1042361) 1 NC_010677.1 rare lipoprotein B family protein 1042361 6290484 FTM_0958 Francisella tularensis subsp. mediasiatica FSC147 rare lipoprotein B family protein YP_001891665.1 1041786 R 441952 CDS YP_001891666.1 187931682 6290486 complement(1042369..1044810) 1 NC_010677.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1044810 leuS 6290486 leuS Francisella tularensis subsp. mediasiatica FSC147 leucyl-tRNA synthetase YP_001891666.1 1042369 R 441952 CDS YP_001891667.1 187931683 6290488 complement(1044918..1046813) 1 NC_010677.1 hypothetical protein 1046813 6290488 FTM_0960 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891667.1 1044918 R 441952 CDS YP_001891668.1 187931684 6290492 complement(1047602..1048012) 1 NC_010677.1 hypothetical protein 1048012 6290492 FTM_0962 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891668.1 1047602 R 441952 CDS YP_001891669.1 187931685 6290494 complement(1048014..1048598) 1 NC_010677.1 hypothetical protein 1048598 6290494 FTM_0963 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891669.1 1048014 R 441952 CDS YP_001891670.1 187931686 6290497 complement(1049234..1049605) 1 NC_010677.1 hypothetical protein 1049605 6290497 FTM_0965 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891670.1 1049234 R 441952 CDS YP_001891671.1 187931687 6290501 complement(1050622..1051788) 1 NC_010677.1 hypothetical protein 1051788 6290501 FTM_0967 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891671.1 1050622 R 441952 CDS YP_001891672.1 187931688 6290502 complement(1052133..1053362) 1 NC_010677.1 hypothetical protein 1053362 6290502 FTM_0968 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891672.1 1052133 R 441952 CDS YP_001891673.1 187931689 6290503 1053584..1054963 1 NC_010677.1 amino acid transporter (AAT) family protein 1054963 6290503 FTM_0969 Francisella tularensis subsp. mediasiatica FSC147 amino acid transporter (AAT) family protein YP_001891673.1 1053584 D 441952 CDS YP_001891674.1 187931690 6290504 1055005..1055610 1 NC_010677.1 membrane protein 1055610 6290504 FTM_0970 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891674.1 1055005 D 441952 CDS YP_001891675.1 187931691 6290505 1055614..1055907 1 NC_010677.1 transcriptional regulator, MarR family 1055907 6290505 FTM_0971 Francisella tularensis subsp. mediasiatica FSC147 transcriptional regulator, MarR family YP_001891675.1 1055614 D 441952 CDS YP_001891676.1 187931692 6290506 complement(1056304..1056630) 1 NC_010677.1 thioredoxin 1056630 trxA2 6290506 trxA2 Francisella tularensis subsp. mediasiatica FSC147 thioredoxin YP_001891676.1 1056304 R 441952 CDS YP_001891677.1 187931693 6290509 complement(1056634..1057323) 1 NC_010677.1 lipoprotein 1057323 6290509 FTM_0973 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891677.1 1056634 R 441952 CDS YP_001891678.1 187931694 6290514 complement(1058279..1059424) 1 NC_010677.1 SufS activator complex, sufD subunit 1059424 sufD 6290514 sufD Francisella tularensis subsp. mediasiatica FSC147 SufS activator complex, sufD subunit YP_001891678.1 1058279 R 441952 CDS YP_001891679.1 187931695 6290515 complement(1059437..1060186) 1 NC_010677.1 sufS activator complex, sufC subunit 1060186 sufC 6290515 sufC Francisella tularensis subsp. mediasiatica FSC147 sufS activator complex, sufC subunit YP_001891679.1 1059437 R 441952 CDS YP_001891680.1 187931696 6290516 complement(1060229..1061671) 1 NC_010677.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1061671 sufB 6290516 sufB Francisella tularensis subsp. mediasiatica FSC147 cysteine desulfurase activator complex subunit SufB YP_001891680.1 1060229 R 441952 CDS YP_001891681.1 187931697 6290517 complement(1061678..1062088) 1 NC_010677.1 FeS assembly SUF system regulator 1062088 6290517 FTM_0978 Francisella tularensis subsp. mediasiatica FSC147 FeS assembly SUF system regulator YP_001891681.1 1061678 R 441952 CDS YP_001891682.1 187931698 6290519 1062241..1063614 1 NC_010677.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1063614 trkA 6290519 trkA Francisella tularensis subsp. mediasiatica FSC147 potassium transporter peripheral membrane protein YP_001891682.1 1062241 D 441952 CDS YP_001891683.1 187931699 6290520 1063673..1065094 1 NC_010677.1 amino acid antiporter 1065094 6290520 FTM_0980 Francisella tularensis subsp. mediasiatica FSC147 amino acid antiporter YP_001891683.1 1063673 D 441952 CDS YP_001891684.1 187931700 6290522 complement(1066056..1066274) 1 NC_010677.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1066274 infA 6290522 infA Francisella tularensis subsp. mediasiatica FSC147 translation initiation factor IF-1 YP_001891684.1 1066056 R 441952 CDS YP_001891685.1 187931701 6290523 1066434..1067273 1 NC_010677.1 hypothetical protein 1067273 6290523 FTM_0983 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891685.1 1066434 D 441952 CDS YP_001891686.1 187931702 6290524 1067270..1067536 1 NC_010677.1 hypothetical protein 1067536 6290524 FTM_0984 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891686.1 1067270 D 441952 CDS YP_001891687.1 187931703 6290525 1067617..1068993 1 NC_010677.1 signal recognition particle GTPase 1068993 ffh 6290525 ffh Francisella tularensis subsp. mediasiatica FSC147 signal recognition particle GTPase YP_001891687.1 1067617 D 441952 CDS YP_001891688.1 187931704 6290526 1069025..1070137 1 NC_010677.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1070137 aroG 6290526 aroG Francisella tularensis subsp. mediasiatica FSC147 phospho-2-dehydro-3-deoxyheptonate aldolase YP_001891688.1 1069025 D 441952 CDS YP_001891689.1 187931705 6290051 1072848..1073636 1 NC_010677.1 exodeoxyribonuclease III 1073636 xthA 6290051 xthA Francisella tularensis subsp. mediasiatica FSC147 exodeoxyribonuclease III YP_001891689.1 1072848 D 441952 CDS YP_001891690.1 187931706 6290531 1073657..1074364 1 NC_010677.1 short chain dehydrogenase 1074364 6290531 FTM_0991 Francisella tularensis subsp. mediasiatica FSC147 short chain dehydrogenase YP_001891690.1 1073657 D 441952 CDS YP_001891691.1 187931707 6290536 1074367..1074870 1 NC_010677.1 putative kinase 1074870 6290536 FTM_0992 Francisella tularensis subsp. mediasiatica FSC147 putative kinase YP_001891691.1 1074367 D 441952 CDS YP_001891692.1 187931708 6290541 1074870..1075589 1 NC_010677.1 membrane protein 1075589 6290541 FTM_0993 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891692.1 1074870 D 441952 CDS YP_001891693.1 187931709 6290542 1075627..1076988 1 NC_010677.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1076988 gor 6290542 gor Francisella tularensis subsp. mediasiatica FSC147 glutathione reductase YP_001891693.1 1075627 D 441952 CDS YP_001891694.1 187931710 6290546 1076999..1077319 1 NC_010677.1 hypothetical protein 1077319 6290546 FTM_0995 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891694.1 1076999 D 441952 CDS YP_001891695.1 187931711 6290548 1077457..1078998 1 NC_010677.1 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 1078998 6290548 FTM_0996 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter YP_001891695.1 1077457 D 441952 CDS YP_001891696.1 187931712 6290550 complement(1078995..1080320) 1 NC_010677.1 ATP-dependent RNA helicase 1080320 6290550 FTM_0997 Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent RNA helicase YP_001891696.1 1078995 R 441952 CDS YP_001891697.1 187931713 6290553 1080447..1081067 1 NC_010677.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1081067 folE 6290553 folE Francisella tularensis subsp. mediasiatica FSC147 GTP cyclohydrolase I YP_001891697.1 1080447 D 441952 CDS YP_001891698.1 187931714 6290557 1081914..1082339 1 NC_010677.1 hypothetical protein 1082339 6290557 FTM_1000 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891698.1 1081914 D 441952 CDS YP_001891699.1 187931715 6290559 1082417..1083337 1 NC_010677.1 carbon-nitrogen hydrolase family protein 1083337 6290559 FTM_1001 Francisella tularensis subsp. mediasiatica FSC147 carbon-nitrogen hydrolase family protein YP_001891699.1 1082417 D 441952 CDS YP_001891700.1 187932319 6290567 complement(1085715..1086269) 1 NC_010677.1 para-aminobenzoate synthase component 1086269 pabA 6290567 pabA Francisella tularensis subsp. mediasiatica FSC147 para-aminobenzoate synthase component YP_001891700.1 1085715 R 441952 CDS YP_001891701.1 187931716 6290569 complement(1086271..1088034) 1 NC_010677.1 para-aminobenzoate synthase component I 1088034 6290569 FTM_1005 Francisella tularensis subsp. mediasiatica FSC147 para-aminobenzoate synthase component I YP_001891701.1 1086271 R 441952 CDS YP_001891702.1 187931717 6290572 complement(1088027..1089397) 1 NC_010677.1 AMP-binding protein 1089397 6290572 FTM_1006 Francisella tularensis subsp. mediasiatica FSC147 AMP-binding protein YP_001891702.1 1088027 R 441952 CDS YP_001891703.1 187931718 6290577 1089479..1089832 1 NC_010677.1 dihydroneopterin aldolase 1089832 folB 6290577 folB Francisella tularensis subsp. mediasiatica FSC147 dihydroneopterin aldolase YP_001891703.1 1089479 D 441952 CDS YP_001891704.1 187931719 6290578 1089834..1091096 1 NC_010677.1 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase 1091096 6290578 FTM_1008 Francisella tularensis subsp. mediasiatica FSC147 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase YP_001891704.1 1089834 D 441952 CDS YP_001891705.1 187931720 6290580 1091109..1092029 1 NC_010677.1 lipase/esterase 1092029 6290580 FTM_1009 Francisella tularensis subsp. mediasiatica FSC147 lipase/esterase YP_001891705.1 1091109 D 441952 CDS YP_001891706.1 187931721 6290581 1092045..1092545 1 NC_010677.1 hypothetical protein 1092545 6290581 FTM_1010 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891706.1 1092045 D 441952 CDS YP_001891707.1 187931722 6290583 complement(1093889..1094884) 1 NC_010677.1 hypothetical protein 1094884 6290583 FTM_1012 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891707.1 1093889 R 441952 CDS YP_001891708.1 187931723 6290586 complement(1096816..1097520) 1 NC_010677.1 hypothetical protein 1097520 6290586 FTM_1014 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891708.1 1096816 R 441952 CDS YP_001891709.1 187931724 6290587 complement(1097551..1097916) 1 NC_010677.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1097916 rplT 6290587 rplT Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L20 YP_001891709.1 1097551 R 441952 CDS YP_001891710.1 187931725 6290588 complement(1097952..1098149) 1 NC_010677.1 50S ribosomal protein L35 1098149 rpmI 6290588 rpmI Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L35 YP_001891710.1 1097952 R 441952 CDS YP_001891711.1 187931726 6290589 complement(1098192..1098704) 1 NC_010677.1 translation initiation factor IF-3 1098704 infC 6290589 infC Francisella tularensis subsp. mediasiatica FSC147 translation initiation factor IF-3 YP_001891711.1 1098192 R 441952 CDS YP_001891712.1 187931727 6290590 complement(1098735..1100639) 1 NC_010677.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1100639 thrS 6290590 thrS Francisella tularensis subsp. mediasiatica FSC147 threonyl-tRNA synthetase YP_001891712.1 1098735 R 441952 CDS YP_001891713.1 187931728 6290592 complement(1102955..1103251) 1 NC_010677.1 hypothetical protein 1103251 6290592 FTM_1020 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891713.1 1102955 R 441952 CDS YP_001891714.1 187931729 6290593 complement(1103241..1103621) 1 NC_010677.1 glycine cleavage system H protein 1103621 gcvH1 6290593 gcvH1 Francisella tularensis subsp. mediasiatica FSC147 glycine cleavage system H protein YP_001891714.1 1103241 R 441952 CDS YP_001891715.1 187931730 6290594 1103725..1104840 1 NC_010677.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1104840 murG 6290594 murG Francisella tularensis subsp. mediasiatica FSC147 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001891715.1 1103725 D 441952 CDS YP_001891716.1 187931731 6290595 1104850..1105188 1 NC_010677.1 hypothetical protein 1105188 6290595 FTM_1023 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891716.1 1104850 D 441952 CDS YP_001891717.1 187931732 6290596 1105188..1105790 1 NC_010677.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1105790 recR 6290596 recR Francisella tularensis subsp. mediasiatica FSC147 recombination protein RecR YP_001891717.1 1105188 D 441952 CDS YP_001891718.1 187931733 6290597 complement(1105798..1107912) 1 NC_010677.1 GDP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase 1107912 spoT 6290597 spoT Francisella tularensis subsp. mediasiatica FSC147 GDP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase YP_001891718.1 1105798 R 441952 CDS YP_001891719.1 187931734 6290599 complement(1107981..1109192) 1 NC_010677.1 hypothetical protein 1109192 6290599 FTM_1026 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891719.1 1107981 R 441952 CDS YP_001891720.1 187931735 6290600 complement(1109194..1109658) 1 NC_010677.1 capsule biosynthesis protein CapC 1109658 capC 6290600 capC Francisella tularensis subsp. mediasiatica FSC147 capsule biosynthesis protein CapC YP_001891720.1 1109194 R 441952 CDS YP_001891721.1 187931736 6290601 complement(1109683..1110900) 1 NC_010677.1 capsule biosynthesis protein CapB 1110900 capB 6290601 capB Francisella tularensis subsp. mediasiatica FSC147 capsule biosynthesis protein CapB YP_001891721.1 1109683 R 441952 CDS YP_001891722.1 187931737 6290602 complement(1110976..1112211) 1 NC_010677.1 major facilitator superfamily protein 1112211 6290602 FTM_1029 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily protein YP_001891722.1 1110976 R 441952 CDS YP_001891723.1 187931738 6290609 complement(1112905..1113768) 1 NC_010677.1 asparaginase 1113768 ans 6290609 ans Francisella tularensis subsp. mediasiatica FSC147 asparaginase YP_001891723.1 1112905 R 441952 CDS YP_001891724.1 187931739 6290610 complement(1113984..1114802) 1 NC_010677.1 cyanophycinase 1114802 cphB 6290610 cphB Francisella tularensis subsp. mediasiatica FSC147 cyanophycinase YP_001891724.1 1113984 R 441952 CDS YP_001891725.1 187931740 6290611 1115005..1116111 1 NC_010677.1 ribokinase, pfkB family protein 1116111 6290611 FTM_1037 Francisella tularensis subsp. mediasiatica FSC147 ribokinase, pfkB family protein YP_001891725.1 1115005 D 441952 CDS YP_001891726.1 187931741 6290612 complement(1116389..1117051) 1 NC_010677.1 haloacid dehalogenase-like hydrolase 1117051 6290612 FTM_1038 Francisella tularensis subsp. mediasiatica FSC147 haloacid dehalogenase-like hydrolase YP_001891726.1 1116389 R 441952 CDS YP_001891727.1 187931742 6290613 complement(1117070..1118083) 1 NC_010677.1 glycosyl transferase family protein 1118083 6290613 FTM_1039 Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family protein YP_001891727.1 1117070 R 441952 CDS YP_001891728.1 187931743 6290614 complement(1118086..1119093) 1 NC_010677.1 glycosyl transferase family 2 protein 1119093 6290614 FTM_1040 Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family 2 protein YP_001891728.1 1118086 R 441952 CDS YP_001891729.1 187931744 6290615 complement(1119110..1120069) 1 NC_010677.1 glycosyl transferase family 2 protein 1120069 6290615 FTM_1041 Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family 2 protein YP_001891729.1 1119110 R 441952 CDS YP_001891730.1 187931745 6290617 complement(1120078..1120761) 1 NC_010677.1 hypothetical protein 1120761 6290617 FTM_1042 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891730.1 1120078 R 441952 CDS YP_001891731.1 187931746 6290618 complement(1120843..1121472) 1 NC_010677.1 methyltransferase domain-containing protein 1121472 6290618 FTM_1043 Francisella tularensis subsp. mediasiatica FSC147 methyltransferase domain-containing protein YP_001891731.1 1120843 R 441952 CDS YP_001891732.1 187931747 6290619 complement(1121465..1122751) 1 NC_010677.1 hypothetical protein 1122751 6290619 FTM_1044 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891732.1 1121465 R 441952 CDS YP_001891733.1 187931748 6290620 complement(1122765..1124447) 1 NC_010677.1 ATP-binding cassette (ABC) superfamily protein 1124447 6290620 FTM_1045 Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette (ABC) superfamily protein YP_001891733.1 1122765 R 441952 CDS YP_001891734.1 187931749 6290621 complement(1124444..1125673) 1 NC_010677.1 glycosyl transferase family protein 1125673 6290621 FTM_1046 Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family protein YP_001891734.1 1124444 R 441952 CDS YP_001891735.1 187931750 6290622 complement(1125677..1126696) 1 NC_010677.1 UDP-glucose 4-epimerase 1126696 galE 6290622 galE Francisella tularensis subsp. mediasiatica FSC147 UDP-glucose 4-epimerase YP_001891735.1 1125677 R 441952 CDS YP_001891736.1 187931751 6290623 complement(1126689..1128083) 1 NC_010677.1 lipopolysaccharide synthesis sugar transferase 1128083 6290623 FTM_1048 Francisella tularensis subsp. mediasiatica FSC147 lipopolysaccharide synthesis sugar transferase YP_001891736.1 1126689 R 441952 CDS YP_001891737.1 187931752 6290921 complement(1128064..1128732) 1 NC_010677.1 D-ribulose-phosphate 3-epimerase 1128732 rpe 6290921 rpe Francisella tularensis subsp. mediasiatica FSC147 D-ribulose-phosphate 3-epimerase YP_001891737.1 1128064 R 441952 CDS YP_001891738.1 187931753 6290624 1128869..1129840 1 NC_010677.1 phosphosugar isomerase 1129840 kpsF 6290624 kpsF Francisella tularensis subsp. mediasiatica FSC147 phosphosugar isomerase YP_001891738.1 1128869 D 441952 CDS YP_001891739.1 187931754 6290627 complement(1130344..1131042) 1 NC_010677.1 hypothetical protein 1131042 6290627 FTM_1052 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891739.1 1130344 R 441952 CDS YP_001891740.1 187931755 6290635 complement(1131039..1131854) 1 NC_010677.1 hypothetical protein 1131854 6290635 FTM_1053 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891740.1 1131039 R 441952 CDS YP_001891741.1 187931756 6290639 complement(1132193..1133155) 1 NC_010677.1 metallo-beta-lactamase superfamily protein 1133155 6290639 FTM_1055 Francisella tularensis subsp. mediasiatica FSC147 metallo-beta-lactamase superfamily protein YP_001891741.1 1132193 R 441952 CDS YP_001891742.1 187931757 6290645 complement(1133302..1134084) 1 NC_010677.1 enoyl-ACP reductase I 1134084 fabI 6290645 fabI Francisella tularensis subsp. mediasiatica FSC147 enoyl-ACP reductase I YP_001891742.1 1133302 R 441952 CDS YP_001891743.1 187931758 6290650 1134360..1135073 1 NC_010677.1 hypothetical protein 1135073 6290650 FTM_1057 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891743.1 1134360 D 441952 CDS YP_001891744.1 187931759 6291191 complement(1138003..1139190) 1 NC_010677.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1139190 dnaJ 6291191 dnaJ Francisella tularensis subsp. mediasiatica FSC147 chaperone protein DnaJ YP_001891744.1 1138003 R 441952 CDS YP_001891745.1 187931760 6290675 complement(1139216..1141144) 1 NC_010677.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1141144 dnaK 6290675 dnaK Francisella tularensis subsp. mediasiatica FSC147 molecular chaperone DnaK YP_001891745.1 1139216 R 441952 CDS YP_001891746.1 187931761 6290680 complement(1141245..1141832) 1 NC_010677.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1141832 grpE 6290680 grpE Francisella tularensis subsp. mediasiatica FSC147 heat shock protein GrpE YP_001891746.1 1141245 R 441952 CDS YP_001891747.1 187931762 6290681 1141921..1143087 1 NC_010677.1 membrane-bound lytic murein transglycosylase A 1143087 mltA 6290681 mltA Francisella tularensis subsp. mediasiatica FSC147 membrane-bound lytic murein transglycosylase A YP_001891747.1 1141921 D 441952 CDS YP_001891748.1 187931763 6290686 1143080..1144264 1 NC_010677.1 protoporphyrinogen oxidase 1144264 hemG 6290686 hemG Francisella tularensis subsp. mediasiatica FSC147 protoporphyrinogen oxidase YP_001891748.1 1143080 D 441952 CDS YP_001891749.1 187931764 6290687 1144403..1144831 1 NC_010677.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1144831 rplM 6290687 rplM Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L13 YP_001891749.1 1144403 D 441952 CDS YP_001891750.1 187931765 6290688 1144847..1145236 1 NC_010677.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1145236 rpsI 6290688 rpsI Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S9 YP_001891750.1 1144847 D 441952 CDS YP_001891751.1 187931766 6290689 1145296..1145913 1 NC_010677.1 macrophage growth locus, subunit A 1145913 mglA 6290689 mglA Francisella tularensis subsp. mediasiatica FSC147 macrophage growth locus, subunit A YP_001891751.1 1145296 D 441952 CDS YP_001891752.1 187931767 6290691 1145915..1146322 1 NC_010677.1 ClpXP protease specificity-enhancing factor 1146322 mglB 6290691 mglB Francisella tularensis subsp. mediasiatica FSC147 ClpXP protease specificity-enhancing factor YP_001891752.1 1145915 D 441952 CDS YP_001891753.1 187931768 6290697 complement(1146350..1147588) 1 NC_010677.1 sodium-solute symporter family protein 1147588 6290697 FTM_1069 Francisella tularensis subsp. mediasiatica FSC147 sodium-solute symporter family protein YP_001891753.1 1146350 R 441952 CDS YP_001891754.1 187931769 6290704 complement(1147581..1148144) 1 NC_010677.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1148144 rnhB 6290704 rnhB Francisella tularensis subsp. mediasiatica FSC147 ribonuclease HII YP_001891754.1 1147581 R 441952 CDS YP_001891755.1 187931770 6290707 complement(1148146..1148889) 1 NC_010677.1 SpoU family rRNA methyltransferase 1148889 6290707 FTM_1071 Francisella tularensis subsp. mediasiatica FSC147 SpoU family rRNA methyltransferase YP_001891755.1 1148146 R 441952 CDS YP_001891756.1 187931771 6290708 complement(1148882..1149337) 1 NC_010677.1 PEP-dependent sugar phosphotransferase system 1149337 ptsN 6290708 ptsN Francisella tularensis subsp. mediasiatica FSC147 PEP-dependent sugar phosphotransferase system YP_001891756.1 1148882 R 441952 CDS YP_001891757.1 187931772 6290712 complement(1149374..1149670) 1 NC_010677.1 sigma54 modulation protein 1149670 6290712 FTM_1073 Francisella tularensis subsp. mediasiatica FSC147 sigma54 modulation protein YP_001891757.1 1149374 R 441952 CDS YP_001891758.1 187931773 6290714 1149789..1150034 1 NC_010677.1 hypothetical protein 1150034 6290714 FTM_1074 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891758.1 1149789 D 441952 CDS YP_001891759.1 187931774 6290715 1150040..1151392 1 NC_010677.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1151392 trmE 6290715 trmE Francisella tularensis subsp. mediasiatica FSC147 tRNA modification GTPase TrmE YP_001891759.1 1150040 D 441952 CDS YP_001891760.1 187931775 6290719 complement(1151402..1151596) 1 NC_010677.1 hypothetical protein 1151596 6290719 FTM_1076 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891760.1 1151402 R 441952 CDS YP_001891761.1 187931776 6290726 1153916..1154839 1 NC_010677.1 cysteine synthase 1154839 cysK 6290726 cysK Francisella tularensis subsp. mediasiatica FSC147 cysteine synthase YP_001891761.1 1153916 D 441952 CDS YP_001891762.1 187931777 6290728 1155101..1155670 1 NC_010677.1 disulfide bond formation protein DsbB family 1155670 6290728 FTM_1080 Francisella tularensis subsp. mediasiatica FSC147 disulfide bond formation protein DsbB family YP_001891762.1 1155101 D 441952 CDS YP_001891763.1 187931778 6290737 1161310..1163772 1 NC_010677.1 hypothetical protein 1163772 pdpA1 6290737 pdpA1 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891763.1 1161310 D 441952 CDS YP_001891764.1 187931779 6290740 1163777..1167058 1 NC_010677.1 hypothetical protein 1167058 pdpB1 6290740 pdpB1 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891764.1 1163777 D 441952 CDS YP_001891765.1 187931780 6290741 1167048..1167425 1 NC_010677.1 lipoprotein 1167425 6290741 FTM_1088 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891765.1 1167048 D 441952 CDS YP_001891766.1 187931781 6290743 1167438..1167932 1 NC_010677.1 hypothetical protein 1167932 6290743 FTM_1089 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891766.1 1167438 D 441952 CDS YP_001891767.1 187931782 6289974 1167937..1169601 1 NC_010677.1 hypothetical protein 1169601 6289974 FTM_1090 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891767.1 1167937 D 441952 CDS YP_001891768.1 187931783 6290745 1169669..1170190 1 NC_010677.1 hypothetical protein 1170190 6290745 FTM_1091 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891768.1 1169669 D 441952 CDS YP_001891769.1 187931784 6290746 1170203..1171633 1 NC_010677.1 hypothetical protein 1171633 6290746 FTM_1092 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891769.1 1170203 D 441952 CDS YP_001891770.1 187931785 6290748 1171646..1172263 1 NC_010677.1 hypothetical protein 1172263 6290748 FTM_1093 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891770.1 1171646 D 441952 CDS YP_001891771.1 187931786 6290750 1172285..1173436 1 NC_010677.1 hypothetical protein 1173436 6290750 FTM_1094 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891771.1 1172285 D 441952 CDS YP_001891772.1 187931787 6290754 1173402..1174175 1 NC_010677.1 hypothetical protein 1174175 6290754 FTM_1095 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891772.1 1173402 D 441952 CDS YP_001891773.1 187931788 6290761 1174215..1178201 1 NC_010677.1 PdpC 1178201 pdpC1 6290761 pdpC1 Francisella tularensis subsp. mediasiatica FSC147 PdpC YP_001891773.1 1174215 D 441952 CDS YP_001891774.1 187931789 6290763 1178219..1178794 1 NC_010677.1 hypothetical protein 1178794 6290763 FTM_1097 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891774.1 1178219 D 441952 CDS YP_001891775.1 187931790 6290766 complement(1178801..1179997) 1 NC_010677.1 intracellular growth locus protein D 1179997 iglD1 6290766 iglD1 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus protein D YP_001891775.1 1178801 R 441952 CDS YP_001891776.1 187931791 6291276 complement(1180018..1180647) 1 NC_010677.1 intracellular growth locus C protein 1180647 iglC1 6291276 iglC1 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus C protein YP_001891776.1 1180018 R 441952 CDS YP_001891777.1 187931792 6290770 complement(1180664..1182184) 1 NC_010677.1 intracellular growth locus protein B 1182184 iglB1 6290770 iglB1 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus protein B YP_001891777.1 1180664 R 441952 CDS YP_001891778.1 187931793 6290771 complement(1182198..1182752) 1 NC_010677.1 intracellular growth locus protein A 1182752 iglA1 6290771 iglA1 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus protein A YP_001891778.1 1182198 R 441952 CDS YP_001891779.1 187931794 6290775 complement(1182833..1186564) 1 NC_010677.1 hypothetical protein 1186564 pdpD1 6290775 pdpD1 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891779.1 1182833 R 441952 CDS YP_001891780.1 187931795 6290776 complement(1186795..1187778) 1 NC_010677.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1187778 anmK 6290776 anmK Francisella tularensis subsp. mediasiatica FSC147 anhydro-N-acetylmuramic acid kinase YP_001891780.1 1186795 R 441952 CDS YP_001891781.1 187931796 6290782 complement(1190083..1190505) 1 NC_010677.1 lipoprotein 1190505 6290782 FTM_1106 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891781.1 1190083 R 441952 CDS YP_001891782.1 187931797 6290784 complement(1190609..1191358) 1 NC_010677.1 NAD+ synthetase 1191358 nadE 6290784 nadE Francisella tularensis subsp. mediasiatica FSC147 NAD+ synthetase YP_001891782.1 1190609 R 441952 CDS YP_001891783.1 187931798 6290786 complement(1191487..1192959) 1 NC_010677.1 outer membrane efflux protein 1192959 6290786 FTM_1108 Francisella tularensis subsp. mediasiatica FSC147 outer membrane efflux protein YP_001891783.1 1191487 R 441952 CDS YP_001891784.1 187931799 6290788 complement(1192969..1193991) 1 NC_010677.1 membrane fusion protein 1193991 6290788 FTM_1109 Francisella tularensis subsp. mediasiatica FSC147 membrane fusion protein YP_001891784.1 1192969 R 441952 CDS YP_001891785.1 187931800 6290790 complement(1194013..1195542) 1 NC_010677.1 drug:H+ antiporter-1 (DHA2) family protein 1195542 6290790 FTM_1110 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 (DHA2) family protein YP_001891785.1 1194013 R 441952 CDS YP_001891786.1 187931801 6290792 1195707..1196534 1 NC_010677.1 transcriptional regulator AraC family protein 1196534 6290792 FTM_1111 Francisella tularensis subsp. mediasiatica FSC147 transcriptional regulator AraC family protein YP_001891786.1 1195707 D 441952 CDS YP_001891787.1 187931802 6290798 complement(1196522..1198213) 1 NC_010677.1 long chain fatty acid CoA ligase 1198213 6290798 FTM_1112 Francisella tularensis subsp. mediasiatica FSC147 long chain fatty acid CoA ligase YP_001891787.1 1196522 R 441952 CDS YP_001891788.1 187931803 6290799 complement(1198321..1199802) 1 NC_010677.1 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 1199802 6290799 FTM_1113 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter YP_001891788.1 1198321 R 441952 CDS YP_001891789.1 187931804 6290800 complement(1200039..1200767) 1 NC_010677.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1200767 6290800 FTM_1114 Francisella tularensis subsp. mediasiatica FSC147 16S ribosomal RNA methyltransferase RsmE YP_001891789.1 1200039 R 441952 CDS YP_001891790.1 187931805 6290806 1200838..1201524 1 NC_010677.1 hypothetical protein 1201524 6290806 FTM_1115 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891790.1 1200838 D 441952 CDS YP_001891791.1 187931806 6290807 complement(1201514..1202212) 1 NC_010677.1 hypothetical protein 1202212 6290807 FTM_1116 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891791.1 1201514 R 441952 CDS YP_001891792.1 187931807 6290809 complement(1202217..1202942) 1 NC_010677.1 hypothetical protein 1202942 6290809 FTM_1117 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891792.1 1202217 R 441952 CDS YP_001891793.1 187931808 6290810 complement(1202952..1203713) 1 NC_010677.1 ATP-binding Cassette (ABC) superfamily protein 1203713 6290810 FTM_1118 Francisella tularensis subsp. mediasiatica FSC147 ATP-binding Cassette (ABC) superfamily protein YP_001891793.1 1202952 R 441952 CDS YP_001891794.1 187931809 6290812 complement(1203728..1204828) 1 NC_010677.1 ABC-type transport system permease protein 1204828 6290812 FTM_1119 Francisella tularensis subsp. mediasiatica FSC147 ABC-type transport system permease protein YP_001891794.1 1203728 R 441952 CDS YP_001891795.1 187931810 6290820 complement(1205693..1206691) 1 NC_010677.1 ribosomal large subunit pseudouridine synthase D 1206691 rluD 6290820 rluD Francisella tularensis subsp. mediasiatica FSC147 ribosomal large subunit pseudouridine synthase D YP_001891795.1 1205693 R 441952 CDS YP_001891796.1 187931811 6290822 1206780..1207604 1 NC_010677.1 competence lipoprotein ComL 1207604 comL 6290822 comL Francisella tularensis subsp. mediasiatica FSC147 competence lipoprotein ComL YP_001891796.1 1206780 D 441952 CDS YP_001891797.1 187931812 6290825 1209114..1210166 1 NC_010677.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1210166 serC 6290825 serC Francisella tularensis subsp. mediasiatica FSC147 phosphoserine aminotransferase YP_001891797.1 1209114 D 441952 CDS YP_001891798.1 187931813 6290826 1210153..1210818 1 NC_010677.1 cytidylate kinase 1210818 cmk 6290826 cmk Francisella tularensis subsp. mediasiatica FSC147 cytidylate kinase YP_001891798.1 1210153 D 441952 CDS YP_001891799.1 187931814 6290829 complement(1210835..1211446) 1 NC_010677.1 short chain dehydrogenase 1211446 6290829 FTM_1127 Francisella tularensis subsp. mediasiatica FSC147 short chain dehydrogenase YP_001891799.1 1210835 R 441952 CDS YP_001891800.1 187931815 6290830 complement(1211449..1211973) 1 NC_010677.1 peroxiredoxin, AhpC-TSA family protein 1211973 6290830 FTM_1128 Francisella tularensis subsp. mediasiatica FSC147 peroxiredoxin, AhpC-TSA family protein YP_001891800.1 1211449 R 441952 CDS YP_001891801.1 187931816 6290831 1212071..1212940 1 NC_010677.1 oxidative stress transcriptional regulator 1212940 oxyR 6290831 oxyR Francisella tularensis subsp. mediasiatica FSC147 oxidative stress transcriptional regulator YP_001891801.1 1212071 D 441952 CDS YP_001891802.1 187931817 6290833 complement(1212943..1213674) 1 NC_010677.1 hypothetical protein 1213674 6290833 FTM_1130 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891802.1 1212943 R 441952 CDS YP_001891803.1 187931818 6290836 complement(1213688..1213960) 1 NC_010677.1 hypothetical protein 1213960 6290836 FTM_1131 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891803.1 1213688 R 441952 CDS YP_001891804.1 187931819 6290837 complement(1214029..1214808) 1 NC_010677.1 hypothetical protein 1214808 6290837 FTM_1132 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891804.1 1214029 R 441952 CDS YP_001891805.1 187931820 6290846 complement(1217739..1219148) 1 NC_010677.1 hypothetical protein 1219148 6290846 FTM_1135 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891805.1 1217739 R 441952 CDS YP_001891806.1 187931821 6290847 complement(1219135..1219608) 1 NC_010677.1 D-alanyl-D-alanine carboxypeptidase 1219608 vanY 6290847 vanY Francisella tularensis subsp. mediasiatica FSC147 D-alanyl-D-alanine carboxypeptidase YP_001891806.1 1219135 R 441952 CDS YP_001891807.1 187931822 6290850 complement(1219602..1220294) 1 NC_010677.1 DNA polymerase III subunit epsilon 1220294 dnaQ 6290850 dnaQ Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase III subunit epsilon YP_001891807.1 1219602 R 441952 CDS YP_001891808.1 187931823 6290856 complement(1221840..1222055) 1 NC_010677.1 membrane protein 1222055 6290856 FTM_1139 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891808.1 1221840 R 441952 CDS YP_001891809.1 187931824 6290860 complement(1222061..1222330) 1 NC_010677.1 phosphonoacetate hydrolase 1222330 phnA 6290860 phnA Francisella tularensis subsp. mediasiatica FSC147 phosphonoacetate hydrolase YP_001891809.1 1222061 R 441952 CDS YP_001891810.1 187931825 6290865 complement(1223940..1224539) 1 NC_010677.1 peroxiredoxin of the AhpC/TSA family 1224539 6290865 FTM_1142 Francisella tularensis subsp. mediasiatica FSC147 peroxiredoxin of the AhpC/TSA family YP_001891810.1 1223940 R 441952 CDS YP_001891811.1 187931826 6290866 1224631..1225212 1 NC_010677.1 haloacid dehalogenase-like hydrolase 1225212 6290866 FTM_1143 Francisella tularensis subsp. mediasiatica FSC147 haloacid dehalogenase-like hydrolase YP_001891811.1 1224631 D 441952 CDS YP_001891812.1 187931827 6290302 1225265..1226767 1 NC_010677.1 hypothetical protein 1226767 6290302 FTM_1144 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891812.1 1225265 D 441952 CDS YP_001891813.1 187931828 6290973 1227585..1228070 1 NC_010677.1 hypothetical protein 1228070 6290973 FTM_1146 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891813.1 1227585 D 441952 CDS YP_001891814.1 187931829 6290261 complement(1228163..1228798) 1 NC_010677.1 ubiquinone biosynthesis protein 1228798 6290261 FTM_1147 Francisella tularensis subsp. mediasiatica FSC147 ubiquinone biosynthesis protein YP_001891814.1 1228163 R 441952 CDS YP_001891815.1 187931830 6290054 complement(1228814..1229326) 1 NC_010677.1 major facilitator superfamily (MFS) transport protein 1229326 6290054 FTM_1148 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily (MFS) transport protein YP_001891815.1 1228814 R 441952 CDS YP_001891816.1 187931831 6291327 1229477..1230436 1 NC_010677.1 Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 1230436 mdh 6291327 mdh Francisella tularensis subsp. mediasiatica FSC147 malate dehydrogenase YP_001891816.1 1229477 D 441952 CDS YP_001891817.1 187931832 6291600 1230640..1232412 1 NC_010677.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1232412 nrdA 6291600 nrdA Francisella tularensis subsp. mediasiatica FSC147 ribonucleotide-diphosphate reductase subunit alpha YP_001891817.1 1230640 D 441952 CDS YP_001891818.1 187931833 6291432 1232416..1232676 1 NC_010677.1 glutaredoxin 1232676 grxA 6291432 grxA Francisella tularensis subsp. mediasiatica FSC147 glutaredoxin YP_001891818.1 1232416 D 441952 CDS YP_001891819.1 187931834 6291192 1232683..1233915 1 NC_010677.1 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta 1233915 6291192 FTM_1152 Francisella tularensis subsp. mediasiatica FSC147 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta YP_001891819.1 1232683 D 441952 CDS YP_001891820.1 187931835 6290380 1235914..1236516 1 NC_010677.1 DJ-1/PfpI family protein 1236516 6290380 FTM_1154 Francisella tularensis subsp. mediasiatica FSC147 DJ-1/PfpI family protein YP_001891820.1 1235914 D 441952 CDS YP_001891821.1 187931836 6290196 1236523..1237572 1 NC_010677.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1237572 6290196 FTM_1155 Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase IV YP_001891821.1 1236523 D 441952 CDS YP_001891822.1 187931837 6290318 complement(1239028..1239684) 1 NC_010677.1 hypothetical protein 1239684 6290318 FTM_1158 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891822.1 1239028 R 441952 CDS YP_001891823.1 187931838 6290452 complement(1241193..1243280) 1 NC_010677.1 N-6 DNA Methylase family 1243280 6290452 FTM_1161 Francisella tularensis subsp. mediasiatica FSC147 N-6 DNA Methylase family YP_001891823.1 1241193 R 441952 CDS YP_001891824.1 187931839 6291283 complement(1243510..1244493) 1 NC_010677.1 tRNA-dihydrouridine synthase 1244493 6291283 FTM_1162 Francisella tularensis subsp. mediasiatica FSC147 tRNA-dihydrouridine synthase YP_001891824.1 1243510 R 441952 CDS YP_001891825.1 187931840 6290498 complement(1244483..1245328) 1 NC_010677.1 50S ribosomal protein L11 methyltransferase 1245328 prmA 6290498 prmA Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L11 methyltransferase YP_001891825.1 1244483 R 441952 CDS YP_001891826.1 187931841 6291239 complement(1245551..1246708) 1 NC_010677.1 Fe-dependent alcohol dehydrogenase YqhD 1246708 yghD 6291239 yghD Francisella tularensis subsp. mediasiatica FSC147 Fe-dependent alcohol dehydrogenase YqhD YP_001891826.1 1245551 R 441952 CDS YP_001891827.1 187931842 6291151 complement(1249841..1250983) 1 NC_010677.1 L-lactate dehydrogenase 1250983 lldD 6291151 lldD Francisella tularensis subsp. mediasiatica FSC147 L-lactate dehydrogenase YP_001891827.1 1249841 R 441952 CDS YP_001891828.1 187931843 6290817 complement(1252233..1253423) 1 NC_010677.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1253423 tyrS 6290817 tyrS Francisella tularensis subsp. mediasiatica FSC147 tyrosyl-tRNA synthetase YP_001891828.1 1252233 R 441952 CDS YP_001891829.1 187931844 6291476 1253537..1254439 1 NC_010677.1 lipoate-protein ligase A 1254439 lplA 6291476 lplA Francisella tularensis subsp. mediasiatica FSC147 lipoate-protein ligase A YP_001891829.1 1253537 D 441952 CDS YP_001891830.1 187931845 6291016 complement(1254442..1255191) 1 NC_010677.1 membrane protein 1255191 6291016 FTM_1169 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891830.1 1254442 R 441952 CDS YP_001891831.1 187931846 6290727 1255383..1255934 1 NC_010677.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 1255934 hslV 6290727 hslV Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent protease peptidase subunit YP_001891831.1 1255383 D 441952 CDS YP_001891832.1 187931847 6290289 1255942..1257309 1 NC_010677.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 1257309 hslU 6290289 hslU Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent protease ATP-binding subunit HslU YP_001891832.1 1255942 D 441952 CDS YP_001891833.1 187931848 6290683 1258943..1260100 1 NC_010677.1 potassium channel protein 1260100 6290683 FTM_1173 Francisella tularensis subsp. mediasiatica FSC147 potassium channel protein YP_001891833.1 1258943 D 441952 CDS YP_001891834.1 187931849 6290299 1260196..1261596 1 NC_010677.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 1261596 udhA 6290299 udhA Francisella tularensis subsp. mediasiatica FSC147 soluble pyridine nucleotide transhydrogenase YP_001891834.1 1260196 D 441952 CDS YP_001891835.1 187931850 6291317 1261627..1262418 1 NC_010677.1 Type IV pili leader peptidase and methylase 1262418 pilD 6291317 pilD Francisella tularensis subsp. mediasiatica FSC147 Type IV pili leader peptidase and methylase YP_001891835.1 1261627 D 441952 CDS YP_001891836.1 187931851 6290883 1262458..1263303 1 NC_010677.1 hypothetical protein 1263303 6290883 FTM_1176 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891836.1 1262458 D 441952 CDS YP_001891837.1 187931852 6291433 1263312..1264196 1 NC_010677.1 beta-lactamase class A 1264196 blaA 6291433 blaA Francisella tularensis subsp. mediasiatica FSC147 beta-lactamase class A YP_001891837.1 1263312 D 441952 CDS YP_001891838.1 187931853 6290458 1264189..1264764 1 NC_010677.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1264764 pth 6290458 pth Francisella tularensis subsp. mediasiatica FSC147 peptidyl-tRNA hydrolase YP_001891838.1 1264189 D 441952 CDS YP_001891839.1 187931854 6290223 1264783..1265874 1 NC_010677.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1265874 ychF 6290223 ychF Francisella tularensis subsp. mediasiatica FSC147 GTP-dependent nucleic acid-binding protein EngD YP_001891839.1 1264783 D 441952 CDS YP_001891840.1 187931855 6291631 1265889..1266164 1 NC_010677.1 lipoprotein 1266164 6291631 FTM_1180 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001891840.1 1265889 D 441952 CDS YP_001891841.1 187931856 6290969 complement(1267754..1269013) 1 NC_010677.1 transporter-associated protein, HlyC/CorC family 1269013 6290969 FTM_1182 Francisella tularensis subsp. mediasiatica FSC147 transporter-associated protein, HlyC/CorC family YP_001891841.1 1267754 R 441952 CDS YP_001891842.1 187931857 6290275 complement(1269109..1269399) 1 NC_010677.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1269399 rplY 6290275 rplY Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L25 YP_001891842.1 1269109 R 441952 CDS YP_001891843.1 187931858 6291001 complement(1269499..1270467) 1 NC_010677.1 ribose-phosphate pyrophosphokinase 1270467 prsA 6291001 prsA Francisella tularensis subsp. mediasiatica FSC147 ribose-phosphate pyrophosphokinase YP_001891843.1 1269499 R 441952 CDS YP_001891844.1 187931859 6291700 complement(1272968..1274245) 1 NC_010677.1 major facilitator superfamily protein 1274245 6291700 FTM_1187 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily protein YP_001891844.1 1272968 R 441952 CDS YP_001891845.1 187931860 6291144 complement(1275356..1276531) 1 NC_010677.1 monovalent cation:proton antiporter family protein 1276531 6291144 FTM_1189 Francisella tularensis subsp. mediasiatica FSC147 monovalent cation:proton antiporter family protein YP_001891845.1 1275356 R 441952 CDS YP_001891846.1 187931861 6290684 complement(1276629..1277261) 1 NC_010677.1 nicotinamide ribonucleoside (NR) uptake permease (PnuC) family protein 1277261 6290684 FTM_1190 Francisella tularensis subsp. mediasiatica FSC147 nicotinamide ribonucleoside (NR) uptake permease (PnuC) family protein YP_001891846.1 1276629 R 441952 CDS YP_001891847.1 187931862 6291443 complement(1277261..1277764) 1 NC_010677.1 isochorismatase family protein 1277764 6291443 FTM_1191 Francisella tularensis subsp. mediasiatica FSC147 isochorismatase family protein YP_001891847.1 1277261 R 441952 CDS YP_001891848.1 187931863 6291204 1278565..1279263 1 NC_010677.1 aldolase/adducin class II family protein 1279263 6291204 FTM_1193 Francisella tularensis subsp. mediasiatica FSC147 aldolase/adducin class II family protein YP_001891848.1 1278565 D 441952 CDS YP_001891849.1 187931864 6290298 1279278..1280414 1 NC_010677.1 catalyzes the formation of histamine from L-histidine; histidine decarboxylase 1280414 hdc 6290298 hdc Francisella tularensis subsp. mediasiatica FSC147 histidine decarboxylase YP_001891849.1 1279278 D 441952 CDS YP_001891850.1 187931865 6290778 complement(1280401..1281213) 1 NC_010677.1 hypothetical protein 1281213 6290778 FTM_1195 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891850.1 1280401 R 441952 CDS YP_001891851.1 187931866 6290648 1281869..1282165 1 NC_010677.1 hypothetical protein 1282165 6290648 FTM_1197 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891851.1 1281869 D 441952 CDS YP_001891852.1 187931867 6291268 complement(1282187..1282774) 1 NC_010677.1 membrane protein 1282774 6291268 FTM_1198 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891852.1 1282187 R 441952 CDS YP_001891853.1 187931868 6291397 complement(1282823..1284238) 1 NC_010677.1 DNA recombination protein RmuC family protein 1284238 6291397 FTM_1199 Francisella tularensis subsp. mediasiatica FSC147 DNA recombination protein RmuC family protein YP_001891853.1 1282823 R 441952 CDS YP_001891854.1 187931869 6290773 complement(1284264..1284914) 1 NC_010677.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1284914 ruvA 6290773 ruvA Francisella tularensis subsp. mediasiatica FSC147 Holliday junction DNA helicase RuvA YP_001891854.1 1284264 R 441952 CDS YP_001891855.1 187931870 6291506 complement(1284927..1286120) 1 NC_010677.1 sugar transporter, MFS superfamily 1286120 6291506 FTM_1201 Francisella tularensis subsp. mediasiatica FSC147 sugar transporter, MFS superfamily YP_001891855.1 1284927 R 441952 CDS YP_001891856.1 187931871 6291171 complement(1286202..1286717) 1 NC_010677.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1286717 ruvC 6291171 ruvC Francisella tularensis subsp. mediasiatica FSC147 Holliday junction resolvase YP_001891856.1 1286202 R 441952 CDS YP_001891857.1 187931872 6291651 complement(1286814..1287560) 1 NC_010677.1 hypothetical protein 1287560 6291651 FTM_1203 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891857.1 1286814 R 441952 CDS YP_001891858.1 187931873 6290384 complement(1287576..1288235) 1 NC_010677.1 isoprenoid biosynthesis protein with amidotransferase-like domain 1288235 6290384 FTM_1204 Francisella tularensis subsp. mediasiatica FSC147 isoprenoid biosynthesis protein with amidotransferase-like domain YP_001891858.1 1287576 R 441952 CDS YP_001891859.1 187931874 6290999 complement(1288265..1289248) 1 NC_010677.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1289248 lipA 6290999 lipA Francisella tularensis subsp. mediasiatica FSC147 lipoyl synthase YP_001891859.1 1288265 R 441952 CDS YP_001891860.1 187931875 6291036 1289455..1289955 1 NC_010677.1 ferric iron binding protein, ferritin-like protein 1289955 ftnA 6291036 ftnA Francisella tularensis subsp. mediasiatica FSC147 ferric iron binding protein, ferritin-like protein YP_001891860.1 1289455 D 441952 CDS YP_001891861.1 187931876 6290942 complement(1289958..1291526) 1 NC_010677.1 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 1291526 6290942 FTM_1207 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter YP_001891861.1 1289958 R 441952 CDS YP_001891862.1 187931877 6290218 1291588..1292232 1 NC_010677.1 cofactor involved in the reduction of disulfides; glutaredoxin 1292232 grxB 6290218 grxB Francisella tularensis subsp. mediasiatica FSC147 glutaredoxin YP_001891862.1 1291588 D 441952 CDS YP_001891863.1 187931878 6290818 1292234..1292863 1 NC_010677.1 iron-sulfur cluster-binding protein 1292863 rnfB 6290818 rnfB Francisella tularensis subsp. mediasiatica FSC147 iron-sulfur cluster-binding protein YP_001891863.1 1292234 D 441952 CDS YP_001891864.1 187931879 6291515 1292856..1293494 1 NC_010677.1 endonuclease III 1293494 nth 6291515 nth Francisella tularensis subsp. mediasiatica FSC147 endonuclease III YP_001891864.1 1292856 D 441952 CDS YP_001891865.1 187931880 6291035 1293491..1293919 1 NC_010677.1 hypothetical protein 1293919 6291035 FTM_1211 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891865.1 1293491 D 441952 CDS YP_001891866.1 187931881 6291624 1293919..1295178 1 NC_010677.1 membrane protein 1295178 6291624 FTM_1212 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001891866.1 1293919 D 441952 CDS YP_001891867.1 187931882 6290537 1295294..1295980 1 NC_010677.1 hypothetical protein 1295980 6290537 FTM_1213 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891867.1 1295294 D 441952 CDS YP_001891868.1 187931883 6290412 1296025..1299450 1 NC_010677.1 transcription-repair coupling factor 1299450 mfd 6290412 mfd Francisella tularensis subsp. mediasiatica FSC147 transcription-repair coupling factor YP_001891868.1 1296025 D 441952 CDS YP_001891869.1 187931884 6290642 complement(1300644..1300961) 1 NC_010677.1 acetolactate synthase small subunit 1300961 ilvN 6290642 ilvN Francisella tularensis subsp. mediasiatica FSC147 acetolactate synthase small subunit YP_001891869.1 1300644 R 441952 CDS YP_001891870.1 187931885 6290456 complement(1302806..1304488) 1 NC_010677.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1304488 ilvD 6290456 ilvD Francisella tularensis subsp. mediasiatica FSC147 dihydroxy-acid dehydratase YP_001891870.1 1302806 R 441952 CDS YP_001891871.1 187931886 6290291 1307899..1308126 1 NC_010677.1 transcriptional regulator 1308126 6290291 FTM_1220 Francisella tularensis subsp. mediasiatica FSC147 transcriptional regulator YP_001891871.1 1307899 D 441952 CDS YP_001891872.1 187931887 6290676 1308129..1309487 1 NC_010677.1 transcriptional regulator 1309487 6290676 FTM_1221 Francisella tularensis subsp. mediasiatica FSC147 transcriptional regulator YP_001891872.1 1308129 D 441952 CDS YP_001891873.1 187931888 6291412 complement(1309509..1310690) 1 NC_010677.1 hypothetical protein 1310690 6291412 FTM_1222 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891873.1 1309509 R 441952 CDS YP_001891874.1 187931889 6291450 complement(1310705..1310965) 1 NC_010677.1 hypothetical protein 1310965 6291450 FTM_1223 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891874.1 1310705 R 441952 CDS YP_001891875.1 187931890 6291025 complement(1313317..1313574) 1 NC_010677.1 hypothetical protein 1313574 6291025 FTM_1227 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891875.1 1313317 R 441952 CDS YP_001891876.1 187931891 6290329 complement(1313579..1314439) 1 NC_010677.1 Required for efficient pilin antigenic variation; recombination associated protein 1314439 rdgC 6290329 rdgC Francisella tularensis subsp. mediasiatica FSC147 recombination associated protein YP_001891876.1 1313579 R 441952 CDS YP_001891877.1 187931892 6291372 1314629..1315615 1 NC_010677.1 putative rhodanese, sulfurtransferase 1315615 6291372 FTM_1229 Francisella tularensis subsp. mediasiatica FSC147 putative rhodanese, sulfurtransferase YP_001891877.1 1314629 D 441952 CDS YP_001891878.1 187931893 6290371 complement(1316632..1318647) 1 NC_010677.1 UvrD/REP superfamily I DNA and RNA helicase 1318647 rep 6290371 rep Francisella tularensis subsp. mediasiatica FSC147 UvrD/REP superfamily I DNA and RNA helicase YP_001891878.1 1316632 R 441952 CDS YP_001891879.1 187931894 6290945 complement(1318641..1319387) 1 NC_010677.1 hypothetical protein 1319387 6290945 FTM_1232 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891879.1 1318641 R 441952 CDS YP_001891880.1 187931895 6291345 1320009..1320512 1 NC_010677.1 isochorismatase hydrolase family protein 1320512 6291345 FTM_1233 Francisella tularensis subsp. mediasiatica FSC147 isochorismatase hydrolase family protein YP_001891880.1 1320009 D 441952 CDS YP_001891881.1 187931896 6291648 1321200..1321688 1 NC_010677.1 isochorismatase hydrolase family protein 1321688 6291648 FTM_1235 Francisella tularensis subsp. mediasiatica FSC147 isochorismatase hydrolase family protein YP_001891881.1 1321200 D 441952 CDS YP_001891882.1 187931897 6291355 complement(1321838..1322296) 1 NC_010677.1 hypothetical protein 1322296 6291355 FTM_1236 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891882.1 1321838 R 441952 CDS YP_001891883.1 187931898 6290871 complement(1322319..1323284) 1 NC_010677.1 transaldolase B 1323284 talA 6290871 talA Francisella tularensis subsp. mediasiatica FSC147 transaldolase B YP_001891883.1 1322319 R 441952 CDS YP_001891884.1 187931899 6290747 complement(1323422..1324801) 1 NC_010677.1 cytosol aminopeptidase 1324801 pepB 6290747 pepB Francisella tularensis subsp. mediasiatica FSC147 cytosol aminopeptidase YP_001891884.1 1323422 R 441952 CDS YP_001891885.1 187931900 6290796 complement(1324804..1326186) 1 NC_010677.1 putative outer membrane efflux protein 1326186 6290796 FTM_1239 Francisella tularensis subsp. mediasiatica FSC147 putative outer membrane efflux protein YP_001891885.1 1324804 R 441952 CDS YP_001891886.1 187931901 6290534 complement(1326194..1328791) 1 NC_010677.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1328791 alaS 6290534 alaS Francisella tularensis subsp. mediasiatica FSC147 alanyl-tRNA synthetase YP_001891886.1 1326194 R 441952 CDS YP_001891887.1 187931902 6291373 1328947..1329393 1 NC_010677.1 hypothetical protein 1329393 6291373 FTM_1241 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891887.1 1328947 D 441952 CDS YP_001891888.1 187931903 6290772 complement(1331481..1331816) 1 NC_010677.1 hypothetical protein 1331816 6290772 FTM_1243 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891888.1 1331481 R 441952 CDS YP_001891889.1 187931904 6291678 1331847..1332254 1 NC_010677.1 hypothetical protein 1332254 6291678 FTM_1244 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891889.1 1331847 D 441952 CDS YP_001891890.1 187931905 6291563 1333741..1334862 1 NC_010677.1 protein-disulfide isomerase 1334862 6291563 FTM_1247 Francisella tularensis subsp. mediasiatica FSC147 protein-disulfide isomerase YP_001891890.1 1333741 D 441952 CDS YP_001891891.1 187931906 6290716 complement(1336311..1337165) 1 NC_010677.1 this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 1337165 6290716 FTM_1249 Francisella tularensis subsp. mediasiatica FSC147 bifunctional methionine sulfoxide reductase B/A protein YP_001891891.1 1336311 R 441952 CDS YP_001891892.1 187931907 6291441 complement(1337762..1339714) 1 NC_010677.1 betaine/carnitine/choline transporter (BCCT) family protein 1339714 betT 6291441 betT Francisella tularensis subsp. mediasiatica FSC147 betaine/carnitine/choline transporter (BCCT) family protein YP_001891892.1 1337762 R 441952 CDS YP_001891893.1 187931908 6290701 1339856..1340608 1 NC_010677.1 rRNA methyltransferase 1340608 spoU 6290701 spoU Francisella tularensis subsp. mediasiatica FSC147 rRNA methyltransferase YP_001891893.1 1339856 D 441952 CDS YP_001891894.1 187931909 6291282 1340702..1341649 1 NC_010677.1 choloylglycine hydrolase family protein 1341649 6291282 FTM_1253 Francisella tularensis subsp. mediasiatica FSC147 choloylglycine hydrolase family protein YP_001891894.1 1340702 D 441952 CDS YP_001891895.1 187931910 6291562 1341814..1342167 1 NC_010677.1 hypothetical protein 1342167 6291562 FTM_1254 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891895.1 1341814 D 441952 CDS YP_001891896.1 187931911 6290755 complement(1343989..1344282) 1 NC_010677.1 hypothetical protein 1344282 6290755 FTM_1256 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891896.1 1343989 R 441952 CDS YP_001891897.1 187931912 6290229 complement(1350948..1352126) 1 NC_010677.1 outer membrane protein FopA 1352126 fopA 6290229 fopA Francisella tularensis subsp. mediasiatica FSC147 outer membrane protein FopA YP_001891897.1 1350948 R 441952 CDS YP_001891898.1 187931913 6291337 complement(1352236..1352481) 1 NC_010677.1 4Fe-4S ferredoxin 1352481 6291337 FTM_1262 Francisella tularensis subsp. mediasiatica FSC147 4Fe-4S ferredoxin YP_001891898.1 1352236 R 441952 CDS YP_001891899.1 187931914 6290632 complement(1352486..1352974) 1 NC_010677.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1352974 coaD 6290632 coaD Francisella tularensis subsp. mediasiatica FSC147 phosphopantetheine adenylyltransferase YP_001891899.1 1352486 R 441952 CDS YP_001891900.1 187931915 6290463 complement(1352986..1353537) 1 NC_010677.1 hypothetical protein 1353537 6290463 FTM_1264 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891900.1 1352986 R 441952 CDS YP_001891901.1 187931916 6291429 complement(1353551..1353907) 1 NC_010677.1 hypothetical protein 1353907 6291429 FTM_1265 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891901.1 1353551 R 441952 CDS YP_001891902.1 187931917 6290934 complement(1353928..1355151) 1 NC_010677.1 selenocysteine lyase 1355151 sufS 6290934 sufS Francisella tularensis subsp. mediasiatica FSC147 selenocysteine lyase YP_001891902.1 1353928 R 441952 CDS YP_001891903.1 187931918 6291489 complement(1355254..1356627) 1 NC_010677.1 L-serine dehydratase 1356627 sdaA 6291489 sdaA Francisella tularensis subsp. mediasiatica FSC147 L-serine dehydratase YP_001891903.1 1355254 R 441952 CDS YP_001891904.1 187931919 6291330 complement(1356683..1357351) 1 NC_010677.1 metal-dependent hydrolase 1357351 6291330 FTM_1268 Francisella tularensis subsp. mediasiatica FSC147 metal-dependent hydrolase YP_001891904.1 1356683 R 441952 CDS YP_001891905.1 187931920 6291123 complement(1357377..1358219) 1 NC_010677.1 prephenate dehydratase 1358219 pheA 6291123 pheA Francisella tularensis subsp. mediasiatica FSC147 prephenate dehydratase YP_001891905.1 1357377 R 441952 CDS YP_001891906.1 187931921 6291127 complement(1359994..1361091) 1 NC_010677.1 alanine racemase 1361091 alr 6291127 alr Francisella tularensis subsp. mediasiatica FSC147 alanine racemase YP_001891906.1 1359994 R 441952 CDS YP_001891907.1 187931922 6290024 complement(1361104..1362597) 1 NC_010677.1 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 1362597 6290024 FTM_1272 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter YP_001891907.1 1361104 R 441952 CDS YP_001891908.1 187931923 6290739 complement(1362722..1363429) 1 NC_010677.1 hypothetical protein 1363429 6290739 FTM_1273 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891908.1 1362722 R 441952 CDS YP_001891909.1 187931924 6290401 complement(1363441..1363836) 1 NC_010677.1 hypothetical protein 1363836 6290401 FTM_1274 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891909.1 1363441 R 441952 CDS YP_001891910.1 187931925 6291418 1363923..1364945 1 NC_010677.1 hypothetical protein 1364945 6291418 FTM_1275 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891910.1 1363923 D 441952 CDS YP_001891911.1 187931926 6290471 complement(1364934..1365584) 1 NC_010677.1 phosphoserine phosphatase 1365584 serB 6290471 serB Francisella tularensis subsp. mediasiatica FSC147 phosphoserine phosphatase YP_001891911.1 1364934 R 441952 CDS YP_001891912.1 187931927 6291310 1366198..1367655 1 NC_010677.1 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 1367655 6291310 FTM_1277 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter YP_001891912.1 1366198 D 441952 CDS YP_001891913.1 187931928 6290539 complement(1367784..1368047) 1 NC_010677.1 hypothetical protein 1368047 6290539 FTM_1278 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891913.1 1367784 R 441952 CDS YP_001891914.1 187931929 6290478 complement(1368983..1369861) 1 NC_010677.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 1369861 rpoH 6290478 rpoH Francisella tularensis subsp. mediasiatica FSC147 RNA polymerase factor sigma-32 YP_001891914.1 1368983 R 441952 CDS YP_001891915.1 187931930 6291375 complement(1369885..1370373) 1 NC_010677.1 hypothetical protein 1370373 6291375 FTM_1280 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891915.1 1369885 R 441952 CDS YP_001891916.1 187931931 6291536 complement(1370447..1371391) 1 NC_010677.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 1371391 secF 6291536 secF Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecF YP_001891916.1 1370447 R 441952 CDS YP_001891917.1 187931932 6291638 complement(1371410..1373347) 1 NC_010677.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1373347 secD 6291638 secD Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecD YP_001891917.1 1371410 R 441952 CDS YP_001891918.1 187931933 6290692 complement(1373404..1373760) 1 NC_010677.1 preprotein translocase subunit YajC 1373760 yajC 6290692 yajC Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit YajC YP_001891918.1 1373404 R 441952 CDS YP_001891919.1 187931934 6290813 complement(1374316..1374888) 1 NC_010677.1 isochorismatase hydrolase family protein 1374888 6290813 FTM_1284 Francisella tularensis subsp. mediasiatica FSC147 isochorismatase hydrolase family protein YP_001891919.1 1374316 R 441952 CDS YP_001891920.1 187931935 6290427 complement(1376739..1377842) 1 NC_010677.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1377842 tgt 6290427 tgt Francisella tularensis subsp. mediasiatica FSC147 queuine tRNA-ribosyltransferase YP_001891920.1 1376739 R 441952 CDS YP_001891921.1 187931936 6290667 complement(1378825..1379091) 1 NC_010677.1 hypothetical protein 1379091 6290667 FTM_1289 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891921.1 1378825 R 441952 CDS YP_001891922.1 187931937 6290019 complement(1379247..1379588) 1 NC_010677.1 hypothetical protein 1379588 6290019 FTM_1290 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891922.1 1379247 R 441952 CDS YP_001891923.1 187931938 6290186 1380224..1380838 1 NC_010677.1 hypothetical protein 1380838 6290186 FTM_1291 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891923.1 1380224 D 441952 CDS YP_001891924.1 187931939 6291377 1381854..1383326 1 NC_010677.1 methionine uptake transporter (MUT) family protein, membrane and periplasmic protein 1383326 metIQ 6291377 metIQ Francisella tularensis subsp. mediasiatica FSC147 methionine uptake transporter (MUT) family protein, membrane and periplasmic protein YP_001891924.1 1381854 D 441952 CDS YP_001891925.1 187931940 6290157 1383397..1384608 1 NC_010677.1 hydroxy/aromatic amino acid permease (HAAAP) family protein 1384608 6290157 FTM_1294 Francisella tularensis subsp. mediasiatica FSC147 hydroxy/aromatic amino acid permease (HAAAP) family protein YP_001891925.1 1383397 D 441952 CDS YP_001891926.1 187931941 6291118 1384683..1385438 1 NC_010677.1 rhodanese-like family protein 1385438 6291118 FTM_1295 Francisella tularensis subsp. mediasiatica FSC147 rhodanese-like family protein YP_001891926.1 1384683 D 441952 CDS YP_001891927.1 187931942 6290532 1385445..1385924 1 NC_010677.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1385924 ispF 6290532 ispF Francisella tularensis subsp. mediasiatica FSC147 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_001891927.1 1385445 D 441952 CDS YP_001891928.1 187931943 6290558 complement(1385929..1387614) 1 NC_010677.1 Mur ligase family protein 1387614 6290558 FTM_1297 Francisella tularensis subsp. mediasiatica FSC147 Mur ligase family protein YP_001891928.1 1385929 R 441952 CDS YP_001891929.1 187931944 6290100 complement(1387640..1390462) 1 NC_010677.1 catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 1390462 cphA 6290100 cphA Francisella tularensis subsp. mediasiatica FSC147 cyanophycin synthetase YP_001891929.1 1387640 R 441952 CDS YP_001891930.1 187931945 6290738 complement(1391317..1392069) 1 NC_010677.1 glycerophosphoryl diester phosphodiesterase 1392069 glpQ 6290738 glpQ Francisella tularensis subsp. mediasiatica FSC147 glycerophosphoryl diester phosphodiesterase YP_001891930.1 1391317 R 441952 CDS YP_001891931.1 187931946 6290760 1392227..1394005 1 NC_010677.1 Type IV pili ATPase 1394005 pilB 6290760 pilB Francisella tularensis subsp. mediasiatica FSC147 Type IV pili ATPase YP_001891931.1 1392227 D 441952 CDS YP_001891932.1 187931947 6290744 1394020..1395249 1 NC_010677.1 Type IV pili polytopic inner membrane protein 1395249 pilC 6290744 pilC Francisella tularensis subsp. mediasiatica FSC147 Type IV pili polytopic inner membrane protein YP_001891932.1 1394020 D 441952 CDS YP_001891933.1 187931948 6291186 complement(1396500..1396889) 1 NC_010677.1 hypothetical protein 1396889 6291186 FTM_1304 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891933.1 1396500 R 441952 CDS YP_001891934.1 187931949 6290926 complement(1396852..1397112) 1 NC_010677.1 hypothetical protein 1397112 6290926 FTM_1305 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891934.1 1396852 R 441952 CDS YP_001891935.1 187931950 6290971 1397246..1398247 1 NC_010677.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1398247 hemH 6290971 hemH Francisella tularensis subsp. mediasiatica FSC147 ferrochelatase YP_001891935.1 1397246 D 441952 CDS YP_001891936.1 187931951 6291420 complement(1402085..1403923) 1 NC_010677.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1403923 uvrC 6291420 uvrC Francisella tularensis subsp. mediasiatica FSC147 excinuclease ABC subunit C YP_001891936.1 1402085 R 441952 CDS YP_001891937.1 187931952 6291080 1404032..1405126 1 NC_010677.1 ribonuclease D 1405126 rnd 6291080 rnd Francisella tularensis subsp. mediasiatica FSC147 ribonuclease D YP_001891937.1 1404032 D 441952 CDS YP_001891938.1 187931953 6291551 1405155..1406369 1 NC_010677.1 drug:H+ antiporter-1 (DHA1) family protein 1406369 6291551 FTM_1313 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 (DHA1) family protein YP_001891938.1 1405155 D 441952 CDS YP_001891939.1 187931954 6291583 complement(1406366..1406743) 1 NC_010677.1 hypothetical protein 1406743 6291583 FTM_1314 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891939.1 1406366 R 441952 CDS YP_001891940.1 187931955 6291585 complement(1407130..1407384) 1 NC_010677.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1407384 rpmA 6291585 rpmA Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L27 YP_001891940.1 1407130 R 441952 CDS YP_001891941.1 187931956 6291607 complement(1407415..1407729) 1 NC_010677.1 50S ribosomal protein L21 1407729 rplU 6291607 rplU Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L21 YP_001891941.1 1407415 R 441952 CDS YP_001891942.1 187931957 6290549 complement(1409797..1412517) 1 NC_010677.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1412517 secA 6290549 secA Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecA YP_001891942.1 1409797 R 441952 CDS YP_001891943.1 187931958 6291591 1412649..1413677 1 NC_010677.1 hypothetical protein 1413677 6291591 FTM_1320 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891943.1 1412649 D 441952 CDS YP_001891944.1 187931959 6290188 1413681..1414130 1 NC_010677.1 hypothetical protein 1414130 6290188 FTM_1321 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891944.1 1413681 D 441952 CDS YP_001891945.1 187931960 6291367 complement(1414127..1414849) 1 NC_010677.1 purine nucleoside phosphorylase 1414849 deoD 6291367 deoD Francisella tularensis subsp. mediasiatica FSC147 purine nucleoside phosphorylase YP_001891945.1 1414127 R 441952 CDS YP_001891946.1 187931961 6290062 complement(1415910..1417856) 1 NC_010677.1 ATP-dependent metalloprotease 1417856 hflB 6290062 hflB Francisella tularensis subsp. mediasiatica FSC147 ATP-dependent metalloprotease YP_001891946.1 1415910 R 441952 CDS YP_001891947.1 187931962 6290254 complement(1419461..1422283) 1 NC_010677.1 excinuclease ABC subunit A 1422283 uvrA 6290254 uvrA Francisella tularensis subsp. mediasiatica FSC147 excinuclease ABC subunit A YP_001891947.1 1419461 R 441952 CDS YP_001891948.1 187931963 6291161 complement(1422322..1422804) 1 NC_010677.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1422804 greA 6291161 greA Francisella tularensis subsp. mediasiatica FSC147 transcription elongation factor GreA YP_001891948.1 1422322 R 441952 CDS YP_001891949.1 187931964 6290430 complement(1422838..1423422) 1 NC_010677.1 type IV pili, pilus assembly protein 1423422 fimT 6290430 fimT Francisella tularensis subsp. mediasiatica FSC147 type IV pili, pilus assembly protein YP_001891949.1 1422838 R 441952 CDS YP_001891950.1 187931965 6290631 complement(1423423..1425045) 1 NC_010677.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1425045 pgi 6290631 pgi Francisella tularensis subsp. mediasiatica FSC147 glucose-6-phosphate isomerase YP_001891950.1 1423423 R 441952 CDS YP_001891951.1 187931966 6290090 complement(1425032..1425685) 1 NC_010677.1 thiamine pyrophosphokinase 1425685 6290090 FTM_1329 Francisella tularensis subsp. mediasiatica FSC147 thiamine pyrophosphokinase YP_001891951.1 1425032 R 441952 CDS YP_001891952.1 187931967 6290690 complement(1425751..1427211) 1 NC_010677.1 IMP dehydrogenase/GMP reductase 1427211 guaB 6290690 guaB Francisella tularensis subsp. mediasiatica FSC147 IMP dehydrogenase/GMP reductase YP_001891952.1 1425751 R 441952 CDS YP_001891953.1 187931968 6290540 complement(1427312..1428751) 1 NC_010677.1 cytosol aminopeptidase 1428751 pepA 6290540 pepA Francisella tularensis subsp. mediasiatica FSC147 cytosol aminopeptidase YP_001891953.1 1427312 R 441952 CDS YP_001891954.1 187931969 6291662 1428917..1429999 1 NC_010677.1 hypothetical protein 1429999 6291662 FTM_1332 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891954.1 1428917 D 441952 CDS YP_001891955.1 187931970 6290142 1429999..1431060 1 NC_010677.1 YjgP/YjgQ family permease 1431060 6290142 FTM_1333 Francisella tularensis subsp. mediasiatica FSC147 YjgP/YjgQ family permease YP_001891955.1 1429999 D 441952 CDS YP_001891956.1 187931971 6291340 1431068..1432321 1 NC_010677.1 metallopeptidase M16 family protein 1432321 6291340 FTM_1334 Francisella tularensis subsp. mediasiatica FSC147 metallopeptidase M16 family protein YP_001891956.1 1431068 D 441952 CDS YP_001891957.1 187931972 6291667 1432328..1433551 1 NC_010677.1 Zn-dependent peptidase M16 family protein 1433551 6291667 FTM_1335 Francisella tularensis subsp. mediasiatica FSC147 Zn-dependent peptidase M16 family protein YP_001891957.1 1432328 D 441952 CDS YP_001891958.1 187931973 6290305 1433552..1434130 1 NC_010677.1 N6-adenine-specific methylase 1434130 6290305 FTM_1336 Francisella tularensis subsp. mediasiatica FSC147 N6-adenine-specific methylase YP_001891958.1 1433552 D 441952 CDS YP_001891959.1 187931974 6290556 1434164..1434814 1 NC_010677.1 hypothetical protein 1434814 6290556 FTM_1337 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891959.1 1434164 D 441952 CDS YP_001891960.1 187931975 6290485 complement(1434867..1435478) 1 NC_010677.1 tRNA-(ms(2)io(6)A)-hydroxylase 1435478 miaE 6290485 miaE Francisella tularensis subsp. mediasiatica FSC147 tRNA-(ms(2)io(6)A)-hydroxylase YP_001891960.1 1434867 R 441952 CDS YP_001891961.1 187931976 6290487 1435594..1436397 1 NC_010677.1 uridine phosphorylase 1436397 udp 6290487 udp Francisella tularensis subsp. mediasiatica FSC147 uridine phosphorylase YP_001891961.1 1435594 D 441952 CDS YP_001891962.1 187931977 6291129 1436418..1436819 1 NC_010677.1 cytidine deaminase 1436819 cdd 6291129 cdd Francisella tularensis subsp. mediasiatica FSC147 cytidine deaminase YP_001891962.1 1436418 D 441952 CDS YP_001891963.1 187931978 6290150 complement(1437017..1440046) 1 NC_010677.1 4Fe-4S ferredoxin 1440046 6290150 FTM_1342 Francisella tularensis subsp. mediasiatica FSC147 4Fe-4S ferredoxin YP_001891963.1 1437017 R 441952 CDS YP_001891964.1 187931979 6290643 1440264..1441802 1 NC_010677.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 1441802 gpmI 6290643 gpmI Francisella tularensis subsp. mediasiatica FSC147 phosphoglyceromutase YP_001891964.1 1440264 D 441952 CDS YP_001891965.1 187931980 6290671 1441817..1443097 1 NC_010677.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1443097 serS 6290671 serS Francisella tularensis subsp. mediasiatica FSC147 seryl-tRNA synthetase YP_001891965.1 1441817 D 441952 CDS YP_001891966.1 187931981 6290139 1443207..1444106 1 NC_010677.1 ROK family protein 1444106 cscK 6290139 cscK Francisella tularensis subsp. mediasiatica FSC147 ROK family protein YP_001891966.1 1443207 D 441952 CDS YP_001891967.1 187931982 6290295 1444184..1445443 1 NC_010677.1 multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) transporter 1445443 6290295 FTM_1346 Francisella tularensis subsp. mediasiatica FSC147 multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) transporter YP_001891967.1 1444184 D 441952 CDS YP_001891968.1 187931983 6290473 complement(1445447..1445647) 1 NC_010677.1 hypothetical protein 1445647 6290473 FTM_1347 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891968.1 1445447 R 441952 CDS YP_001891969.1 187931984 6290413 complement(1445675..1446184) 1 NC_010677.1 hypothetical protein 1446184 6290413 FTM_1348 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891969.1 1445675 R 441952 CDS YP_001891970.1 187931985 6290160 1446561..1448342 1 NC_010677.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1448342 cydD 6290160 cydD Francisella tularensis subsp. mediasiatica FSC147 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_001891970.1 1446561 D 441952 CDS YP_001891971.1 187931986 6291056 1448339..1449988 1 NC_010677.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1449988 cydC 6291056 cydC Francisella tularensis subsp. mediasiatica FSC147 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_001891971.1 1448339 D 441952 CDS YP_001891972.1 187931987 6290995 complement(1449990..1451240) 1 NC_010677.1 aerobic C4-dicarboxylate transport protein 1451240 dctA 6290995 dctA Francisella tularensis subsp. mediasiatica FSC147 aerobic C4-dicarboxylate transport protein YP_001891972.1 1449990 R 441952 CDS YP_001891973.1 187931988 6290076 complement(1451379..1451759) 1 NC_010677.1 endoribonuclease L-PSP 1451759 6290076 FTM_1352 Francisella tularensis subsp. mediasiatica FSC147 endoribonuclease L-PSP YP_001891973.1 1451379 R 441952 CDS YP_001891974.1 187931989 6290101 complement(1453577..1454695) 1 NC_010677.1 ABC transporter membrane protein 1454695 6290101 FTM_1354 Francisella tularensis subsp. mediasiatica FSC147 ABC transporter membrane protein YP_001891974.1 1453577 R 441952 CDS YP_001891975.1 187931990 6291187 complement(1455621..1456424) 1 NC_010677.1 hypothetical protein 1456424 6291187 FTM_1356 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891975.1 1455621 R 441952 CDS YP_001891976.1 187931991 6291556 1456730..1457764 1 NC_010677.1 glycerophosphoryl diester phosphodiesterase family protein 1457764 ugpQ 6291556 ugpQ Francisella tularensis subsp. mediasiatica FSC147 glycerophosphoryl diester phosphodiesterase family protein YP_001891976.1 1456730 D 441952 CDS YP_001891977.1 187931992 6291523 1457871..1459187 1 NC_010677.1 glycerol-3-phosphate transporter 1459187 glpT 6291523 glpT Francisella tularensis subsp. mediasiatica FSC147 glycerol-3-phosphate transporter YP_001891977.1 1457871 D 441952 CDS YP_001891978.1 187931993 6290122 1463195..1465420 1 NC_010677.1 peroxidase/catalase 1465420 katG 6290122 katG Francisella tularensis subsp. mediasiatica FSC147 peroxidase/catalase YP_001891978.1 1463195 D 441952 CDS YP_001891979.1 187931994 6291230 1465524..1466849 1 NC_010677.1 dGTP triphosphohydrolase 1466849 6291230 FTM_1362 Francisella tularensis subsp. mediasiatica FSC147 dGTP triphosphohydrolase YP_001891979.1 1465524 D 441952 CDS YP_001891980.1 187931995 6290039 complement(1466833..1468053) 1 NC_010677.1 metabolite:H+ symporter (MHS) family protein 1468053 6290039 FTM_1363 Francisella tularensis subsp. mediasiatica FSC147 metabolite:H+ symporter (MHS) family protein YP_001891980.1 1466833 R 441952 CDS YP_001891981.1 187931996 6290307 complement(1468114..1468458) 1 NC_010677.1 hypothetical protein 1468458 6290307 FTM_1364 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891981.1 1468114 R 441952 CDS YP_001891982.1 187931997 6290058 complement(1469466..1470095) 1 NC_010677.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1470095 upp 6290058 upp Francisella tularensis subsp. mediasiatica FSC147 uracil phosphoribosyltransferase YP_001891982.1 1469466 R 441952 CDS YP_001891983.1 187931998 6290508 complement(1470289..1472619) 1 NC_010677.1 chitinase, glycosyl hydrolase family 18 1472619 chiA 6290508 chiA Francisella tularensis subsp. mediasiatica FSC147 chitinase, glycosyl hydrolase family 18 YP_001891983.1 1470289 R 441952 CDS YP_001891984.1 187931999 6290851 1473153..1474349 1 NC_010677.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 1474349 kbl 6290851 kbl Francisella tularensis subsp. mediasiatica FSC147 2-amino-3-ketobutyrate coenzyme A ligase YP_001891984.1 1473153 D 441952 CDS YP_001891985.1 187932000 6290512 1474372..1475427 1 NC_010677.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 1475427 tdh 6290512 tdh Francisella tularensis subsp. mediasiatica FSC147 L-threonine 3-dehydrogenase YP_001891985.1 1474372 D 441952 CDS YP_001891986.1 187932001 6290194 1475429..1476691 1 NC_010677.1 serine permease 1476691 6290194 FTM_1370 Francisella tularensis subsp. mediasiatica FSC147 serine permease YP_001891986.1 1475429 D 441952 CDS YP_001891987.1 187932002 6290140 complement(1476696..1477385) 1 NC_010677.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1477385 ispD 6290140 ispD Francisella tularensis subsp. mediasiatica FSC147 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_001891987.1 1476696 R 441952 CDS YP_001891988.1 187932003 6289983 complement(1477375..1477665) 1 NC_010677.1 cell division protein, septum formation initiator 1477665 ftsB 6289983 ftsB Francisella tularensis subsp. mediasiatica FSC147 cell division protein, septum formation initiator YP_001891988.1 1477375 R 441952 CDS YP_001891989.1 187932004 6290135 complement(1477673..1479043) 1 NC_010677.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1479043 eno 6290135 eno Francisella tularensis subsp. mediasiatica FSC147 phosphopyruvate hydratase YP_001891989.1 1477673 R 441952 CDS YP_001891990.1 187932005 6290538 complement(1479152..1480390) 1 NC_010677.1 major facilitator superfamily (MFS) transport protein 1480390 6290538 FTM_1374 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily (MFS) transport protein YP_001891990.1 1479152 R 441952 CDS YP_001891991.1 187932006 6291073 complement(1480493..1481257) 1 NC_010677.1 nicotinamide mononucleotide transport (NMT) family protein 1481257 6291073 FTM_1375 Francisella tularensis subsp. mediasiatica FSC147 nicotinamide mononucleotide transport (NMT) family protein YP_001891991.1 1480493 R 441952 CDS YP_001891992.1 187932007 6290031 complement(1481277..1482224) 1 NC_010677.1 ROK family protein 1482224 6290031 FTM_1376 Francisella tularensis subsp. mediasiatica FSC147 ROK family protein YP_001891992.1 1481277 R 441952 CDS YP_001891993.1 187932008 6290368 complement(1482224..1483189) 1 NC_010677.1 ROK family protein 1483189 6290368 FTM_1377 Francisella tularensis subsp. mediasiatica FSC147 ROK family protein YP_001891993.1 1482224 R 441952 CDS YP_001891994.1 187932009 6291116 complement(1483199..1484548) 1 NC_010677.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 1484548 rumA 6291116 rumA Francisella tularensis subsp. mediasiatica FSC147 23S rRNA 5-methyluridine methyltransferase YP_001891994.1 1483199 R 441952 CDS YP_001891995.1 187932010 6291095 complement(1484637..1485209) 1 NC_010677.1 hypothetical protein 1485209 6291095 FTM_1379 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001891995.1 1484637 R 441952 CDS YP_001891996.1 187932011 6291384 complement(1485474..1485692) 1 NC_010677.1 DNA-directed RNA polymerase subunit omega 1485692 rpoZ 6291384 rpoZ Francisella tularensis subsp. mediasiatica FSC147 DNA-directed RNA polymerase subunit omega YP_001891996.1 1485474 R 441952 CDS YP_001891997.1 187932012 6291698 complement(1485685..1486350) 1 NC_010677.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1486350 udk 6291698 udk Francisella tularensis subsp. mediasiatica FSC147 uridine kinase YP_001891997.1 1485685 R 441952 CDS YP_001891998.1 187932013 6290912 complement(1486361..1487188) 1 NC_010677.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1487188 kdsA 6290912 kdsA Francisella tularensis subsp. mediasiatica FSC147 2-dehydro-3-deoxyphosphooctonate aldolase YP_001891998.1 1486361 R 441952 CDS YP_001891999.1 187932014 6291565 complement(1487219..1487569) 1 NC_010677.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 1487569 6291565 FTM_1384 Francisella tularensis subsp. mediasiatica FSC147 iron-sulfur cluster insertion protein ErpA YP_001891999.1 1487219 R 441952 CDS YP_001892000.1 187932015 6290630 complement(1487575..1489656) 1 NC_010677.1 polynucleotide phosphorylase/polyadenylase 1489656 pnp 6290630 pnp Francisella tularensis subsp. mediasiatica FSC147 polynucleotide phosphorylase/polyadenylase YP_001892000.1 1487575 R 441952 CDS YP_001892001.1 187932016 6290915 complement(1489712..1489978) 1 NC_010677.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1489978 rpsO 6290915 rpsO Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S15 YP_001892001.1 1489712 R 441952 CDS YP_001892002.1 187932017 6290980 complement(1490085..1491779) 1 NC_010677.1 cell division protein, peptidoglycan synthetase (PBP) 1491779 ftsI 6290980 ftsI Francisella tularensis subsp. mediasiatica FSC147 cell division protein, peptidoglycan synthetase (PBP) YP_001892002.1 1490085 R 441952 CDS YP_001892003.1 187932018 6290332 complement(1491772..1492122) 1 NC_010677.1 hypothetical protein 1492122 6290332 FTM_1388 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892003.1 1491772 R 441952 CDS YP_001892004.1 187932019 6290084 complement(1492119..1493036) 1 NC_010677.1 S-adenosyl-methyltransferase MraW 1493036 mraW 6290084 mraW Francisella tularensis subsp. mediasiatica FSC147 S-adenosyl-methyltransferase MraW YP_001892004.1 1492119 R 441952 CDS YP_001892005.1 187932020 6291173 complement(1493042..1495141) 1 NC_010677.1 hypothetical protein 1495141 6291173 FTM_1390 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892005.1 1493042 R 441952 CDS YP_001892006.1 187932021 6290141 1495235..1496059 1 NC_010677.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1496059 mutM 6290141 mutM Francisella tularensis subsp. mediasiatica FSC147 formamidopyrimidine-DNA glycosylase YP_001892006.1 1495235 D 441952 CDS YP_001892007.1 187932022 6291314 complement(1496888..1497427) 1 NC_010677.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1497427 6291314 FTM_1392 Francisella tularensis subsp. mediasiatica FSC147 glutamine amidotransferase subunit PdxT YP_001892007.1 1496888 R 441952 CDS YP_001892008.1 187932023 6291645 complement(1497430..1498293) 1 NC_010677.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1498293 6291645 FTM_1393 Francisella tularensis subsp. mediasiatica FSC147 pyridoxal biosynthesis lyase PdxS YP_001892008.1 1497430 R 441952 CDS YP_001892009.1 187932024 6291641 complement(1498423..1500834) 1 NC_010677.1 DNA gyrase subunit B 1500834 gyrB 6291641 gyrB Francisella tularensis subsp. mediasiatica FSC147 DNA gyrase subunit B YP_001892009.1 1498423 R 441952 CDS YP_001892010.1 187932025 6290274 1501016..1501816 1 NC_010677.1 hypothetical protein 1501816 6290274 FTM_1395 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892010.1 1501016 D 441952 CDS YP_001892011.1 187932026 6290315 1501850..1502833 1 NC_010677.1 tRNA-dihydrouridine synthase A 1502833 6290315 FTM_1396 Francisella tularensis subsp. mediasiatica FSC147 tRNA-dihydrouridine synthase A YP_001892011.1 1501850 D 441952 CDS YP_001892012.1 187932027 6290780 complement(1502840..1503607) 1 NC_010677.1 protein-disulfide isomerase 1503607 6290780 FTM_1397 Francisella tularensis subsp. mediasiatica FSC147 protein-disulfide isomerase YP_001892012.1 1502840 R 441952 CDS YP_001892013.1 187932028 6291656 complement(1504597..1506510) 1 NC_010677.1 hypothetical protein 1506510 6291656 FTM_1399 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892013.1 1504597 R 441952 CDS YP_001892014.1 187932029 6290313 1506680..1507843 1 NC_010677.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1507843 sucC 6290313 sucC Francisella tularensis subsp. mediasiatica FSC147 succinyl-CoA synthetase subunit beta YP_001892014.1 1506680 D 441952 CDS YP_001892015.1 187932030 6289986 1507875..1508747 1 NC_010677.1 succinyl-CoA ligase [ADP-forming] subunit alpha 1508747 sucD 6289986 sucD Francisella tularensis subsp. mediasiatica FSC147 succinyl-CoA ligase [ADP-forming] subunit alpha YP_001892015.1 1507875 D 441952 CDS YP_001892016.1 187932031 6291145 1508859..1509284 1 NC_010677.1 membrane protein 1509284 6291145 FTM_1402 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001892016.1 1508859 D 441952 CDS YP_001892017.1 187932032 6291693 1509667..1510707 1 NC_010677.1 hypothetical protein 1510707 6291693 FTM_1403 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892017.1 1509667 D 441952 CDS YP_001892018.1 187932033 6290802 complement(1510839..1512056) 1 NC_010677.1 hypothetical protein 1512056 6290802 FTM_1404 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892018.1 1510839 R 441952 CDS YP_001892019.1 187932034 6290711 1512286..1513731 1 NC_010677.1 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter 1513731 6290711 FTM_1405 Francisella tularensis subsp. mediasiatica FSC147 proton-dependent oligopeptide transporter (POT) family protein, di- or tripeptide:H+ symporter YP_001892019.1 1512286 D 441952 CDS YP_001892020.1 187932035 6290280 1513735..1514655 1 NC_010677.1 asparaginase 1514655 6290280 FTM_1406 Francisella tularensis subsp. mediasiatica FSC147 asparaginase YP_001892020.1 1513735 D 441952 CDS YP_001892021.1 187932036 6290665 complement(1515432..1515935) 1 NC_010677.1 hypothetical protein 1515935 6290665 FTM_1408 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892021.1 1515432 R 441952 CDS YP_001892022.1 187932037 6291306 1516268..1516990 1 NC_010677.1 copper homeostasis protein CutC family protein 1516990 cutC 6291306 cutC Francisella tularensis subsp. mediasiatica FSC147 copper homeostasis protein CutC family protein YP_001892022.1 1516268 D 441952 CDS YP_001892023.1 187932038 6290983 complement(1517033..1518172) 1 NC_010677.1 hypothetical protein 1518172 araJ 6290983 araJ Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892023.1 1517033 R 441952 CDS YP_001892024.1 187932039 6289971 1519246..1519920 1 NC_010677.1 phosphoglycolate phosphatase 1519920 gph 6289971 gph Francisella tularensis subsp. mediasiatica FSC147 phosphoglycolate phosphatase YP_001892024.1 1519246 D 441952 CDS YP_001892025.1 187932040 6290392 1521271..1522221 1 NC_010677.1 thioredoxin reductase 1522221 trxB 6290392 trxB Francisella tularensis subsp. mediasiatica FSC147 thioredoxin reductase YP_001892025.1 1521271 D 441952 CDS YP_001892026.1 187932041 6291379 1522329..1523495 1 NC_010677.1 major facilitator superfamily (MFS) transport protein 1523495 6291379 FTM_1415 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily (MFS) transport protein YP_001892026.1 1522329 D 441952 CDS YP_001892027.1 187932042 6290493 complement(1524593..1526395) 1 NC_010677.1 DNA mismatch repair enzyme with ATPase activity 1526395 mutL 6290493 mutL Francisella tularensis subsp. mediasiatica FSC147 DNA mismatch repair enzyme with ATPase activity YP_001892027.1 1524593 R 441952 CDS YP_001892028.1 187932043 6291241 complement(1526403..1527065) 1 NC_010677.1 hypothetical protein 1527065 6291241 FTM_1418 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892028.1 1526403 R 441952 CDS YP_001892029.1 187932044 6290082 complement(1527133..1527852) 1 NC_010677.1 hypothetical protein 1527852 6290082 FTM_1419 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892029.1 1527133 R 441952 CDS YP_001892030.1 187932045 6290095 1528006..1528893 1 NC_010677.1 GTPase 1528893 6290095 FTM_1420 Francisella tularensis subsp. mediasiatica FSC147 GTPase YP_001892030.1 1528006 D 441952 CDS YP_001892031.1 187932046 6290843 1529110..1529925 1 NC_010677.1 lipoprotein 1529925 6290843 FTM_1421 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001892031.1 1529110 D 441952 CDS YP_001892032.1 187932047 6290045 complement(1530178..1531359) 1 NC_010677.1 ATP-binding cassette putrescine uptake system, periplasmic protein 1531359 potF 6290045 potF Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette putrescine uptake system, periplasmic protein YP_001892032.1 1530178 R 441952 CDS YP_001892033.1 187932048 6290467 1531443..1532852 1 NC_010677.1 amino acid-polyamine-organocation (APC) superfamily protein 1532852 6290467 FTM_1423 Francisella tularensis subsp. mediasiatica FSC147 amino acid-polyamine-organocation (APC) superfamily protein YP_001892033.1 1531443 D 441952 CDS YP_001892034.1 187932049 6290252 1532954..1534060 1 NC_010677.1 PerM family protein 1534060 perM 6290252 perM Francisella tularensis subsp. mediasiatica FSC147 PerM family protein YP_001892034.1 1532954 D 441952 CDS YP_001892035.1 187932050 6290490 1534054..1535796 1 NC_010677.1 single-stranded-DNA-specific exonuclease RecJ 1535796 recJ 6290490 recJ Francisella tularensis subsp. mediasiatica FSC147 single-stranded-DNA-specific exonuclease RecJ YP_001892035.1 1534054 D 441952 CDS YP_001892036.1 187932051 6290002 1535793..1536575 1 NC_010677.1 birA-like protein 1536575 6290002 FTM_1426 Francisella tularensis subsp. mediasiatica FSC147 birA-like protein YP_001892036.1 1535793 D 441952 CDS YP_001892037.1 187932052 6290993 1536572..1537495 1 NC_010677.1 tRNA synthetase 1537495 6290993 FTM_1427 Francisella tularensis subsp. mediasiatica FSC147 tRNA synthetase YP_001892037.1 1536572 D 441952 CDS YP_001892038.1 187932053 6290162 complement(1537500..1538618) 1 NC_010677.1 mechanosensitive ion channel protein 1538618 6290162 FTM_1428 Francisella tularensis subsp. mediasiatica FSC147 mechanosensitive ion channel protein YP_001892038.1 1537500 R 441952 CDS YP_001892039.1 187932054 6290129 complement(1538644..1539324) 1 NC_010677.1 membrane protein 1539324 6290129 FTM_1429 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001892039.1 1538644 R 441952 CDS YP_001892040.1 187932055 6291013 complement(1539418..1540773) 1 NC_010677.1 acetyl-CoA carboxylase, biotin carboxylase subunit 1540773 accC 6291013 accC Francisella tularensis subsp. mediasiatica FSC147 acetyl-CoA carboxylase, biotin carboxylase subunit YP_001892040.1 1539418 R 441952 CDS YP_001892041.1 187932056 6291596 complement(1540838..1541311) 1 NC_010677.1 acetyl-CoA carboxylase, biotin carboxy carrier protein subunit 1541311 accB 6291596 accB Francisella tularensis subsp. mediasiatica FSC147 acetyl-CoA carboxylase, biotin carboxy carrier protein subunit YP_001892041.1 1540838 R 441952 CDS YP_001892042.1 187932057 6291111 complement(1541316..1541753) 1 NC_010677.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1541753 aroD 6291111 aroD Francisella tularensis subsp. mediasiatica FSC147 3-dehydroquinate dehydratase YP_001892042.1 1541316 R 441952 CDS YP_001892043.1 187932058 6290199 complement(1541757..1542584) 1 NC_010677.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 1542584 apaH 6290199 apaH Francisella tularensis subsp. mediasiatica FSC147 diadenosine tetraphosphatase YP_001892043.1 1541757 R 441952 CDS YP_001892044.1 187932059 6290156 complement(1542596..1543384) 1 NC_010677.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1543384 ksgA 6290156 ksgA Francisella tularensis subsp. mediasiatica FSC147 dimethyladenosine transferase YP_001892044.1 1542596 R 441952 CDS YP_001892045.1 187932060 6290433 complement(1543386..1544795) 1 NC_010677.1 peptidyl-prolyl cis-trans isomerase 1544795 6290433 FTM_1435 Francisella tularensis subsp. mediasiatica FSC147 peptidyl-prolyl cis-trans isomerase YP_001892045.1 1543386 R 441952 CDS YP_001892046.1 187932061 6291232 complement(1544795..1547398) 1 NC_010677.1 organic solvent tolerance protein 1547398 ostA1 6291232 ostA1 Francisella tularensis subsp. mediasiatica FSC147 organic solvent tolerance protein YP_001892046.1 1544795 R 441952 CDS YP_001892047.1 187932062 6290729 1547525..1549270 1 NC_010677.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1549270 argS 6290729 argS Francisella tularensis subsp. mediasiatica FSC147 arginyl-tRNA synthetase YP_001892047.1 1547525 D 441952 CDS YP_001892048.1 187932063 6290301 complement(1549311..1549691) 1 NC_010677.1 hypothetical protein 1549691 6290301 FTM_1438 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892048.1 1549311 R 441952 CDS YP_001892049.1 187932064 6290244 complement(1551403..1551870) 1 NC_010677.1 RNA methyltransferase, SpoU family 1551870 6290244 FTM_1440 Francisella tularensis subsp. mediasiatica FSC147 RNA methyltransferase, SpoU family YP_001892049.1 1551403 R 441952 CDS YP_001892050.1 187932065 6290032 complement(1551874..1552848) 1 NC_010677.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1552848 hemB 6290032 hemB Francisella tularensis subsp. mediasiatica FSC147 delta-aminolevulinic acid dehydratase YP_001892050.1 1551874 R 441952 CDS YP_001892051.1 187932066 6290420 complement(1552856..1553134) 1 NC_010677.1 RNA-binding protein 1553134 yhbY 6290420 yhbY Francisella tularensis subsp. mediasiatica FSC147 RNA-binding protein YP_001892051.1 1552856 R 441952 CDS YP_001892052.1 187932067 6290085 complement(1553145..1554056) 1 NC_010677.1 DNA polymerase III, delta prime subunit 1554056 holB 6290085 holB Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase III, delta prime subunit YP_001892052.1 1553145 R 441952 CDS YP_001892053.1 187932068 6290073 complement(1554064..1555080) 1 NC_010677.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1555080 sohB 6290073 sohB Francisella tularensis subsp. mediasiatica FSC147 putative periplasmic protease YP_001892053.1 1554064 R 441952 CDS YP_001892054.1 187932069 6291085 complement(1555092..1555724) 1 NC_010677.1 stringent starvation protein A 1555724 sspA 6291085 sspA Francisella tularensis subsp. mediasiatica FSC147 stringent starvation protein A YP_001892054.1 1555092 R 441952 CDS YP_001892055.1 187932070 6291344 1555805..1556119 1 NC_010677.1 hypothetical protein 1556119 6291344 FTM_1446 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892055.1 1555805 D 441952 CDS YP_001892056.1 187932071 6290304 1556140..1556403 1 NC_010677.1 hypothetical protein 1556403 6290304 FTM_1447 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892056.1 1556140 D 441952 CDS YP_001892057.1 187932072 6290967 1556495..1558258 1 NC_010677.1 dolichyl-phosphate-mannose-protein mannosyltransferase family protein 1558258 6290967 FTM_1448 Francisella tularensis subsp. mediasiatica FSC147 dolichyl-phosphate-mannose-protein mannosyltransferase family protein YP_001892057.1 1556495 D 441952 CDS YP_001892058.1 187932073 6291021 complement(1558650..1559606) 1 NC_010677.1 glycosyltransferase 1559606 6291021 FTM_1449 Francisella tularensis subsp. mediasiatica FSC147 glycosyltransferase YP_001892058.1 1558650 R 441952 CDS YP_001892059.1 187932074 6290096 1559705..1560511 1 NC_010677.1 hypothetical protein 1560511 6290096 FTM_1450 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892059.1 1559705 D 441952 CDS YP_001892060.1 187932075 6290870 complement(1560519..1561724) 1 NC_010677.1 cell division protein FtsW 1561724 ftsW 6290870 ftsW Francisella tularensis subsp. mediasiatica FSC147 cell division protein FtsW YP_001892060.1 1560519 R 441952 CDS YP_001892061.1 187932076 6290878 complement(1561734..1562984) 1 NC_010677.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase 1562984 murD 6290878 murD Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylmuramoylalanine--D-glutamate ligase YP_001892061.1 1561734 R 441952 CDS YP_001892062.1 187932077 6290908 complement(1562984..1564081) 1 NC_010677.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1564081 mraY 6290908 mraY Francisella tularensis subsp. mediasiatica FSC147 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001892062.1 1562984 R 441952 CDS YP_001892063.1 187932078 6290917 complement(1564156..1565748) 1 NC_010677.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1565748 pckA 6290917 pckA Francisella tularensis subsp. mediasiatica FSC147 phosphoenolpyruvate carboxykinase YP_001892063.1 1564156 R 441952 CDS YP_001892064.1 187932079 6290925 1565893..1567539 1 NC_010677.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1567539 glnS 6290925 glnS Francisella tularensis subsp. mediasiatica FSC147 glutaminyl-tRNA synthetase YP_001892064.1 1565893 D 441952 CDS YP_001892065.1 187932080 6290960 complement(1570527..1572368) 1 NC_010677.1 drug resistance ATPase-1 family protein 1572368 yjjK 6290960 yjjK Francisella tularensis subsp. mediasiatica FSC147 drug resistance ATPase-1 family protein YP_001892065.1 1570527 R 441952 CDS YP_001892066.1 187932081 6290962 complement(1572402..1573628) 1 NC_010677.1 drug:H+ antiporter-1 (DHA1) family protein 1573628 6290962 FTM_1459 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 (DHA1) family protein YP_001892066.1 1572402 R 441952 CDS YP_001892067.1 187932082 6290979 complement(1573711..1574754) 1 NC_010677.1 hypothetical protein 1574754 6290979 FTM_1460 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892067.1 1573711 R 441952 CDS YP_001892068.1 187932083 6291046 1576220..1576801 1 NC_010677.1 hypothetical protein 1576801 6291046 FTM_1462 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892068.1 1576220 D 441952 CDS YP_001892069.1 187932084 6291055 complement(1577876..1578391) 1 NC_010677.1 acetyltransferase 1578391 6291055 FTM_1464 Francisella tularensis subsp. mediasiatica FSC147 acetyltransferase YP_001892069.1 1577876 R 441952 CDS YP_001892070.1 187932085 6291057 complement(1578396..1579112) 1 NC_010677.1 hypothetical protein 1579112 6291057 FTM_1465 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892070.1 1578396 R 441952 CDS YP_001892071.1 187932086 6291104 1579881..1580516 1 NC_010677.1 homoserine/threonine efflux family protein 1580516 rhtB 6291104 rhtB Francisella tularensis subsp. mediasiatica FSC147 homoserine/threonine efflux family protein YP_001892071.1 1579881 D 441952 CDS YP_001892072.1 187932087 6291128 complement(1580513..1581403) 1 NC_010677.1 NAD kinase 1581403 ppnK 6291128 ppnK Francisella tularensis subsp. mediasiatica FSC147 NAD kinase YP_001892072.1 1580513 R 441952 CDS YP_001892073.1 187932088 6291207 1581591..1582535 1 NC_010677.1 glycosyl transferase family protein 1582535 gtrB 6291207 gtrB Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family protein YP_001892073.1 1581591 D 441952 CDS YP_001892074.1 187932089 6291212 complement(1582539..1583318) 1 NC_010677.1 ATP-binding cassette (ABC) superfamily protein 1583318 6291212 FTM_1470 Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette (ABC) superfamily protein YP_001892074.1 1582539 R 441952 CDS YP_001892075.1 187932090 6291219 complement(1583327..1584250) 1 NC_010677.1 ATP-binding cassette (ABC) superfamily protein 1584250 6291219 FTM_1471 Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette (ABC) superfamily protein YP_001892075.1 1583327 R 441952 CDS YP_001892076.1 187932091 6291228 complement(1585213..1585989) 1 NC_010677.1 hypothetical protein 1585989 6291228 FTM_1472 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892076.1 1585213 R 441952 CDS YP_001892077.1 187932092 6291238 complement(1586439..1587206) 1 NC_010677.1 Mg-dependent DNase 1587206 6291238 FTM_1473 Francisella tularensis subsp. mediasiatica FSC147 Mg-dependent DNase YP_001892077.1 1586439 R 441952 CDS YP_001892078.1 187932093 6291257 1588919..1589359 1 NC_010677.1 bacterioferritin 1589359 bfr 6291257 bfr Francisella tularensis subsp. mediasiatica FSC147 bacterioferritin YP_001892078.1 1588919 D 441952 CDS YP_001892079.1 187932094 6291285 complement(1589977..1590933) 1 NC_010677.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1590933 6291285 FTM_1477 Francisella tularensis subsp. mediasiatica FSC147 DNA-directed RNA polymerase subunit alpha YP_001892079.1 1589977 R 441952 CDS YP_001892080.1 187932095 6290330 complement(1592487..1593413) 1 NC_010677.1 exopolyphosphatase 1593413 ppx 6290330 ppx Francisella tularensis subsp. mediasiatica FSC147 exopolyphosphatase YP_001892080.1 1592487 R 441952 CDS YP_001892081.1 187932096 6291332 1593611..1593934 1 NC_010677.1 thioredoxin 1593934 trxA1 6291332 trxA1 Francisella tularensis subsp. mediasiatica FSC147 thioredoxin YP_001892081.1 1593611 D 441952 CDS YP_001892082.1 187932097 6291339 1593977..1595239 1 NC_010677.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1595239 rho 6291339 rho Francisella tularensis subsp. mediasiatica FSC147 transcription termination factor Rho YP_001892082.1 1593977 D 441952 CDS YP_001892083.1 187932098 6291357 complement(1596356..1597840) 1 NC_010677.1 phosphomannomutase 1597840 manB 6291357 manB Francisella tularensis subsp. mediasiatica FSC147 phosphomannomutase YP_001892083.1 1596356 R 441952 CDS YP_001892084.1 187932099 6291382 complement(1597871..1599277) 1 NC_010677.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase 1599277 manC 6291382 manC Francisella tularensis subsp. mediasiatica FSC147 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase YP_001892084.1 1597871 R 441952 CDS YP_001892085.1 187932100 6291391 complement(1600425..1601474) 1 NC_010677.1 dTDP-glucose 4,6-dehydratase 1601474 wbtM 6291391 wbtM Francisella tularensis subsp. mediasiatica FSC147 dTDP-glucose 4,6-dehydratase YP_001892085.1 1600425 R 441952 CDS YP_001892086.1 187932101 6291392 complement(1601992..1602876) 1 NC_010677.1 glucose-1-phosphate thymidylyltransferase 1602876 wbtL 6291392 wbtL Francisella tularensis subsp. mediasiatica FSC147 glucose-1-phosphate thymidylyltransferase YP_001892086.1 1601992 R 441952 CDS YP_001892087.1 187932102 6291444 complement(1602901..1603761) 1 NC_010677.1 glycosyltransferase 1603761 wbtK 6291444 wbtK Francisella tularensis subsp. mediasiatica FSC147 glycosyltransferase YP_001892087.1 1602901 R 441952 CDS YP_001892088.1 187932103 6291478 complement(1603754..1605241) 1 NC_010677.1 O-antigen flippase 1605241 wzx 6291478 wzx Francisella tularensis subsp. mediasiatica FSC147 O-antigen flippase YP_001892088.1 1603754 R 441952 CDS YP_001892089.1 187932104 6291483 complement(1605246..1605971) 1 NC_010677.1 hypothetical protein 1605971 wbtJ 6291483 wbtJ Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892089.1 1605246 R 441952 CDS YP_001892090.1 187932105 6291496 complement(1605968..1607050) 1 NC_010677.1 sugar transamine/perosamine synthetase 1607050 wbtI 6291496 wbtI Francisella tularensis subsp. mediasiatica FSC147 sugar transamine/perosamine synthetase YP_001892090.1 1605968 R 441952 CDS YP_001892091.1 187932106 6291511 complement(1607043..1608929) 1 NC_010677.1 glutamine amidotransferase/asparagine synthase 1608929 wbtH 6291511 wbtH Francisella tularensis subsp. mediasiatica FSC147 glutamine amidotransferase/asparagine synthase YP_001892091.1 1607043 R 441952 CDS YP_001892092.1 187932107 6291513 complement(1608929..1610029) 1 NC_010677.1 glycosyl transferase family protein 1610029 wbtG 6291513 wbtG Francisella tularensis subsp. mediasiatica FSC147 glycosyl transferase family protein YP_001892092.1 1608929 R 441952 CDS YP_001892093.1 187932108 6291519 complement(1610026..1611255) 1 NC_010677.1 membrane protein/O-antigen protein 1611255 wzy 6291519 wzy Francisella tularensis subsp. mediasiatica FSC147 membrane protein/O-antigen protein YP_001892093.1 1610026 R 441952 CDS YP_001892094.1 187932109 6291520 complement(1611276..1612247) 1 NC_010677.1 NAD dependent epimerase 1612247 wbtF 6291520 wbtF Francisella tularensis subsp. mediasiatica FSC147 NAD dependent epimerase YP_001892094.1 1611276 R 441952 CDS YP_001892095.1 187932110 6291526 complement(1612247..1613557) 1 NC_010677.1 UDP-glucose/GDP-mannose dehydrogenase 1613557 wbtE 6291526 wbtE Francisella tularensis subsp. mediasiatica FSC147 UDP-glucose/GDP-mannose dehydrogenase YP_001892095.1 1612247 R 441952 CDS YP_001892096.1 187932111 6291527 complement(1613575..1614666) 1 NC_010677.1 group 1 glycosyl transferase 1614666 wbtD 6291527 wbtD Francisella tularensis subsp. mediasiatica FSC147 group 1 glycosyl transferase YP_001892096.1 1613575 R 441952 CDS YP_001892097.1 187932112 6291533 complement(1614656..1615447) 1 NC_010677.1 UDP-glucose 4-epimerase 1615447 wbtC 6291533 wbtC Francisella tularensis subsp. mediasiatica FSC147 UDP-glucose 4-epimerase YP_001892097.1 1614656 R 441952 CDS YP_001892098.1 187932113 6291534 complement(1615449..1616081) 1 NC_010677.1 galactosyl transferase 1616081 wbtB 6291534 wbtB Francisella tularensis subsp. mediasiatica FSC147 galactosyl transferase YP_001892098.1 1615449 R 441952 CDS YP_001892099.1 187932114 6291549 complement(1616074..1617810) 1 NC_010677.1 dTDP-glucose 4,6-dehydratase 1617810 wbtA 6291549 wbtA Francisella tularensis subsp. mediasiatica FSC147 dTDP-glucose 4,6-dehydratase YP_001892099.1 1616074 R 441952 CDS YP_001892100.1 187932115 6291555 1618968..1620317 1 NC_010677.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1620317 gdhA 6291555 gdhA Francisella tularensis subsp. mediasiatica FSC147 glutamate dehydrogenase YP_001892100.1 1618968 D 441952 CDS YP_001892101.1 187932116 6291566 complement(1622357..1623322) 1 NC_010677.1 hypothetical protein 1623322 6291566 FTM_1500 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892101.1 1622357 R 441952 CDS YP_001892102.1 187932117 6291576 complement(1625146..1625583) 1 NC_010677.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 1625583 rplQ 6291576 rplQ Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L17 YP_001892102.1 1625146 R 441952 CDS YP_001892103.1 187932118 6291582 complement(1625628..1626599) 1 NC_010677.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1626599 rpoA 6291582 rpoA Francisella tularensis subsp. mediasiatica FSC147 DNA-directed RNA polymerase subunit alpha YP_001892103.1 1625628 R 441952 CDS YP_001892104.1 187932119 6291590 complement(1626657..1627277) 1 NC_010677.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1627277 rpsD 6291590 rpsD Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S4 YP_001892104.1 1626657 R 441952 CDS YP_001892105.1 187932120 6291606 complement(1627299..1627688) 1 NC_010677.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 1627688 rpsK 6291606 rpsK Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S11 YP_001892105.1 1627299 R 441952 CDS YP_001892106.1 187932121 6291612 complement(1627727..1628083) 1 NC_010677.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 1628083 rpsM 6291612 rpsM Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S13 YP_001892106.1 1627727 R 441952 CDS YP_001892107.1 187932122 6291617 complement(1628200..1628313) 1 NC_010677.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 1628313 rpmJ 6291617 rpmJ Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L36 YP_001892107.1 1628200 R 441952 CDS YP_001892108.1 187932123 6291623 complement(1628337..1629662) 1 NC_010677.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1629662 secY 6291623 secY Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecY YP_001892108.1 1628337 R 441952 CDS YP_001892109.1 187932124 6291625 complement(1629673..1630104) 1 NC_010677.1 late assembly protein; 50S ribosomal protein L15 1630104 rplO 6291625 rplO Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L15 YP_001892109.1 1629673 R 441952 CDS YP_001892110.1 187932125 6291628 complement(1630111..1630296) 1 NC_010677.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 1630296 rpmD 6291628 rpmD Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L30 YP_001892110.1 1630111 R 441952 CDS YP_001892111.1 187932126 6291630 complement(1630303..1630803) 1 NC_010677.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 1630803 rpsE 6291630 rpsE Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S5 YP_001892111.1 1630303 R 441952 CDS YP_001892112.1 187932127 6291640 complement(1630831..1631184) 1 NC_010677.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 1631184 rplR 6291640 rplR Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L18 YP_001892112.1 1630831 R 441952 CDS YP_001892113.1 187932128 6291650 complement(1631207..1631743) 1 NC_010677.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 1631743 rplF 6291650 rplF Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L6 YP_001892113.1 1631207 R 441952 CDS YP_001892114.1 187932129 6291654 complement(1631762..1632160) 1 NC_010677.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 1632160 rpsH 6291654 rpsH Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S8 YP_001892114.1 1631762 R 441952 CDS YP_001892115.1 187932130 6291660 complement(1632177..1632482) 1 NC_010677.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1632482 rpsN 6291660 rpsN Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S14 YP_001892115.1 1632177 R 441952 CDS YP_001892116.1 187932131 6291664 complement(1632501..1633040) 1 NC_010677.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 1633040 rplE 6291664 rplE Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L5 YP_001892116.1 1632501 R 441952 CDS YP_001892117.1 187932132 6291676 complement(1633052..1633369) 1 NC_010677.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 1633369 rplX 6291676 rplX Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L24 YP_001892117.1 1633052 R 441952 CDS YP_001892118.1 187932133 6291701 complement(1633391..1633759) 1 NC_010677.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 1633759 rplN 6291701 rplN Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L14 YP_001892118.1 1633391 R 441952 CDS YP_001892119.1 187932134 6290417 complement(1633850..1634101) 1 NC_010677.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 1634101 rpsQ 6290417 rpsQ Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S17 YP_001892119.1 1633850 R 441952 CDS YP_001892120.1 187932135 6290207 complement(1634114..1634314) 1 NC_010677.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 1634314 rpmC 6290207 rpmC Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L29 YP_001892120.1 1634114 R 441952 CDS YP_001892121.1 187932136 6290902 complement(1634314..1634727) 1 NC_010677.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 1634727 rplP 6290902 rplP Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L16 YP_001892121.1 1634314 R 441952 CDS YP_001892122.1 187932137 6291291 complement(1634727..1635398) 1 NC_010677.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 1635398 rpsC 6291291 rpsC Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S3 YP_001892122.1 1634727 R 441952 CDS YP_001892123.1 187932138 6291366 complement(1635413..1635748) 1 NC_010677.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1635748 rplV 6291366 rplV Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L22 YP_001892123.1 1635413 R 441952 CDS YP_001892124.1 187932139 6291156 complement(1635764..1636042) 1 NC_010677.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1636042 rpsS 6291156 rpsS Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S19 YP_001892124.1 1635764 R 441952 CDS YP_001892125.1 187932140 6290241 complement(1636057..1636881) 1 NC_010677.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1636881 rplB 6290241 rplB Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L2 YP_001892125.1 1636057 R 441952 CDS YP_001892126.1 187932141 6290570 complement(1636903..1637202) 1 NC_010677.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1637202 rplW 6290570 rplW Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L23 YP_001892126.1 1636903 R 441952 CDS YP_001892127.1 187932142 6291041 complement(1637199..1637822) 1 NC_010677.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1637822 rplD 6291041 rplD Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L4 YP_001892127.1 1637199 R 441952 CDS YP_001892128.1 187932143 6290579 complement(1637855..1638487) 1 NC_010677.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1638487 rplC 6290579 rplC Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L3 YP_001892128.1 1637855 R 441952 CDS YP_001892129.1 187932144 6290336 complement(1638591..1638908) 1 NC_010677.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 1638908 rpsJ 6290336 rpsJ Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S10 YP_001892129.1 1638591 R 441952 CDS YP_001892130.1 187932145 6290952 complement(1638929..1641043) 1 NC_010677.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 1641043 fusA 6290952 fusA Francisella tularensis subsp. mediasiatica FSC147 elongation factor G YP_001892130.1 1638929 R 441952 CDS YP_001892131.1 187932146 6290961 complement(1641058..1641531) 1 NC_010677.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 1641531 rpsG 6290961 rpsG Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S7 YP_001892131.1 1641058 R 441952 CDS YP_001892132.1 187932147 6290872 complement(1641570..1641944) 1 NC_010677.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 1641944 rpsL 6290872 rpsL Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S12 YP_001892132.1 1641570 R 441952 CDS YP_001892133.1 187932148 6291610 complement(1642079..1642675) 1 NC_010677.1 phosphatidylglycerophosphate synthetase 1642675 pgsA 6291610 pgsA Francisella tularensis subsp. mediasiatica FSC147 phosphatidylglycerophosphate synthetase YP_001892133.1 1642079 R 441952 CDS YP_001892134.1 187932149 6291558 complement(1642679..1643125) 1 NC_010677.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1643125 dut 6291558 dut Francisella tularensis subsp. mediasiatica FSC147 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001892134.1 1642679 R 441952 CDS YP_001892135.1 187932150 6291409 complement(1643135..1643929) 1 NC_010677.1 phosphatidate cytidylyltransferase 1643929 cdsA 6291409 cdsA Francisella tularensis subsp. mediasiatica FSC147 phosphatidate cytidylyltransferase YP_001892135.1 1643135 R 441952 CDS YP_001892136.1 187932151 6291512 complement(1643943..1644665) 1 NC_010677.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 1644665 uppS 6291512 uppS Francisella tularensis subsp. mediasiatica FSC147 undecaprenyl pyrophosphate synthase YP_001892136.1 1643943 R 441952 CDS YP_001892137.1 187932152 6291475 complement(1644749..1645306) 1 NC_010677.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 1645306 frr 6291475 frr Francisella tularensis subsp. mediasiatica FSC147 ribosome recycling factor YP_001892137.1 1644749 R 441952 CDS YP_001892138.1 187932153 6291456 complement(1645335..1646084) 1 NC_010677.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1646084 pyrH 6291456 pyrH Francisella tularensis subsp. mediasiatica FSC147 uridylate kinase YP_001892138.1 1645335 R 441952 CDS YP_001892139.1 187932154 6291044 complement(1646088..1646957) 1 NC_010677.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1646957 tsf 6291044 tsf Francisella tularensis subsp. mediasiatica FSC147 elongation factor Ts YP_001892139.1 1646088 R 441952 CDS YP_001892140.1 187932155 6291277 complement(1646979..1647698) 1 NC_010677.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1647698 rpsB 6291277 rpsB Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S2 YP_001892140.1 1646979 R 441952 CDS YP_001892141.1 187932156 6290986 1647890..1648432 1 NC_010677.1 dihydrofolate reductase 1648432 folA 6290986 folA Francisella tularensis subsp. mediasiatica FSC147 dihydrofolate reductase YP_001892141.1 1647890 D 441952 CDS YP_001892142.1 187932157 6291038 1648514..1649437 1 NC_010677.1 hypothetical protein 1649437 6291038 FTM_1541 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892142.1 1648514 D 441952 CDS YP_001892143.1 187932158 6291042 complement(1652284..1653252) 1 NC_010677.1 hypothetical protein 1653252 6291042 FTM_1544 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892143.1 1652284 R 441952 CDS YP_001892144.1 187932159 6291039 complement(1653252..1654658) 1 NC_010677.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1654658 gltX 6291039 gltX Francisella tularensis subsp. mediasiatica FSC147 glutamyl-tRNA synthetase YP_001892144.1 1653252 R 441952 CDS YP_001892145.1 187932160 6291137 complement(1654788..1656179) 1 NC_010677.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1656179 fumC 6291137 fumC Francisella tularensis subsp. mediasiatica FSC147 fumarate hydratase YP_001892145.1 1654788 R 441952 CDS YP_001892146.1 187932161 6291066 1656868..1657521 1 NC_010677.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 1657521 nfnB 6291066 nfnB Francisella tularensis subsp. mediasiatica FSC147 dihydropteridine reductase YP_001892146.1 1656868 D 441952 CDS YP_001892147.1 187932162 6291598 1657548..1658705 1 NC_010677.1 L-lactate dehydrogenase 1658705 6291598 FTM_1549 Francisella tularensis subsp. mediasiatica FSC147 L-lactate dehydrogenase YP_001892147.1 1657548 D 441952 CDS YP_001892148.1 187932163 6290994 complement(1658702..1659037) 1 NC_010677.1 membrane protein 1659037 6290994 FTM_1550 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001892148.1 1658702 R 441952 CDS YP_001892149.1 187932164 6291569 complement(1659221..1661023) 1 NC_010677.1 hypothetical protein 1661023 6291569 FTM_1551 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892149.1 1659221 R 441952 CDS YP_001892150.1 187932165 6290982 complement(1661052..1663811) 1 NC_010677.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1663811 valS 6290982 valS Francisella tularensis subsp. mediasiatica FSC147 valyl-tRNA synthetase YP_001892150.1 1661052 R 441952 CDS YP_001892151.1 187932166 6291019 complement(1663943..1664383) 1 NC_010677.1 DNA polymerase III subunit chi 1664383 holC 6291019 holC Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase III subunit chi YP_001892151.1 1663943 R 441952 CDS YP_001892152.1 187932167 6291082 complement(1664414..1664896) 1 NC_010677.1 membrane protein 1664896 6291082 FTM_1554 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001892152.1 1664414 R 441952 CDS YP_001892153.1 187932168 6291136 complement(1664904..1665572) 1 NC_010677.1 pyrrolidone carboxylylate peptidase 1665572 pcp 6291136 pcp Francisella tularensis subsp. mediasiatica FSC147 pyrrolidone carboxylylate peptidase YP_001892153.1 1664904 R 441952 CDS YP_001892154.1 187932169 6291063 complement(1665579..1667204) 1 NC_010677.1 hypothetical protein 1667204 6291063 FTM_1556 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892154.1 1665579 R 441952 CDS YP_001892155.1 187932170 6290884 complement(1667194..1668027) 1 NC_010677.1 hypothetical protein 1668027 6290884 FTM_1557 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892155.1 1667194 R 441952 CDS YP_001892156.1 187932171 6291359 complement(1668018..1669016) 1 NC_010677.1 membrane protein with von Willebrand factor type A domain 1669016 6291359 FTM_1558 Francisella tularensis subsp. mediasiatica FSC147 membrane protein with von Willebrand factor type A domain YP_001892156.1 1668018 R 441952 CDS YP_001892157.1 187932172 6291307 complement(1669018..1670019) 1 NC_010677.1 hypothetical protein 1670019 6291307 FTM_1559 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892157.1 1669018 R 441952 CDS YP_001892158.1 187932173 6291491 complement(1670016..1670492) 1 NC_010677.1 hypothetical protein 1670492 6291491 FTM_1560 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892158.1 1670016 R 441952 CDS YP_001892159.1 187932174 6291574 complement(1670482..1671393) 1 NC_010677.1 hypothetical protein 1671393 6291574 FTM_1561 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892159.1 1670482 R 441952 CDS YP_001892160.1 187932175 6291490 complement(1671406..1672362) 1 NC_010677.1 MoxR-like ATPase 1672362 6291490 FTM_1562 Francisella tularensis subsp. mediasiatica FSC147 MoxR-like ATPase YP_001892160.1 1671406 R 441952 CDS YP_001892161.1 187932176 6291561 1672508..1672942 1 NC_010677.1 lipoprotein 1672942 6291561 FTM_1563 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001892161.1 1672508 D 441952 CDS YP_001892162.1 187932177 6291431 1672949..1673800 1 NC_010677.1 pyridoxal kinase 1673800 pdxY 6291431 pdxY Francisella tularensis subsp. mediasiatica FSC147 pyridoxal kinase YP_001892162.1 1672949 D 441952 CDS YP_001892163.1 187932178 6291415 1673800..1674495 1 NC_010677.1 hypothetical protein 1674495 6291415 FTM_1565 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892163.1 1673800 D 441952 CDS YP_001892164.1 187932179 6291236 1674570..1675613 1 NC_010677.1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 1675613 lpxD2 6291236 lpxD2 Francisella tularensis subsp. mediasiatica FSC147 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001892164.1 1674570 D 441952 CDS YP_001892165.1 187932180 6291231 complement(1675758..1676606) 1 NC_010677.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1676606 cyoE 6291231 cyoE Francisella tularensis subsp. mediasiatica FSC147 protoheme IX farnesyltransferase YP_001892165.1 1675758 R 441952 CDS YP_001892166.1 187932181 6291246 complement(1676637..1676969) 1 NC_010677.1 cytochrome bo terminal oxidase subunit IV 1676969 cyoD 6291246 cyoD Francisella tularensis subsp. mediasiatica FSC147 cytochrome bo terminal oxidase subunit IV YP_001892166.1 1676637 R 441952 CDS YP_001892167.1 187932182 6290974 complement(1676971..1677573) 1 NC_010677.1 cytochrome bo terminal oxidase subunit III 1677573 cyoC 6290974 cyoC Francisella tularensis subsp. mediasiatica FSC147 cytochrome bo terminal oxidase subunit III YP_001892167.1 1676971 R 441952 CDS YP_001892168.1 187932183 6290359 complement(1677570..1679600) 1 NC_010677.1 cytochrome bo terminal oxidase subunit I 1679600 cyoB 6290359 cyoB Francisella tularensis subsp. mediasiatica FSC147 cytochrome bo terminal oxidase subunit I YP_001892168.1 1677570 R 441952 CDS YP_001892169.1 187932184 6291622 complement(1679639..1680541) 1 NC_010677.1 cytochrome bo terminal oxidase subunit II 1680541 cyoA 6291622 cyoA Francisella tularensis subsp. mediasiatica FSC147 cytochrome bo terminal oxidase subunit II YP_001892169.1 1679639 R 441952 CDS YP_001892170.1 187932185 6291459 1680901..1682268 1 NC_010677.1 major facilitator superfamily (MFS) transport protein 1682268 6291459 FTM_1572 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily (MFS) transport protein YP_001892170.1 1680901 D 441952 CDS YP_001892171.1 187932186 6291609 1682722..1684476 1 NC_010677.1 cytochrome bd-I terminal oxidase subunit I 1684476 cydA 6291609 cydA Francisella tularensis subsp. mediasiatica FSC147 cytochrome bd-I terminal oxidase subunit I YP_001892171.1 1682722 D 441952 CDS YP_001892172.1 187932187 6291381 1684487..1685680 1 NC_010677.1 cytochrome bd-I terminal oxidase subunit II 1685680 cydB 6291381 cydB Francisella tularensis subsp. mediasiatica FSC147 cytochrome bd-I terminal oxidase subunit II YP_001892172.1 1684487 D 441952 CDS YP_001892173.1 187932188 6291530 1685913..1686611 1 NC_010677.1 polar amino acid uptake transporter 1686611 6291530 FTM_1575 Francisella tularensis subsp. mediasiatica FSC147 polar amino acid uptake transporter YP_001892173.1 1685913 D 441952 CDS YP_001892174.1 187932189 6291302 complement(1690304..1691272) 1 NC_010677.1 hypothetical protein 1691272 6291302 FTM_1578 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892174.1 1690304 R 441952 CDS YP_001892175.1 187932190 6291120 1691462..1693318 1 NC_010677.1 ribonuclease II family protein 1693318 6291120 FTM_1579 Francisella tularensis subsp. mediasiatica FSC147 ribonuclease II family protein YP_001892175.1 1691462 D 441952 CDS YP_001892176.1 187932191 6291176 1693664..1694317 1 NC_010677.1 acarboxylesterase/phospholipase family protein 1694317 6291176 FTM_1580 Francisella tularensis subsp. mediasiatica FSC147 acarboxylesterase/phospholipase family protein YP_001892176.1 1693664 D 441952 CDS YP_001892177.1 187932192 6291143 1694314..1695216 1 NC_010677.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 1695216 hemC 6291143 hemC Francisella tularensis subsp. mediasiatica FSC147 porphobilinogen deaminase YP_001892177.1 1694314 D 441952 CDS YP_001892178.1 187932193 6291211 1695217..1695609 1 NC_010677.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1695609 crcB 6291211 crcB Francisella tularensis subsp. mediasiatica FSC147 camphor resistance protein CrcB YP_001892178.1 1695217 D 441952 CDS YP_001892179.1 187932194 6290901 1695606..1696013 1 NC_010677.1 membrane protein 1696013 6290901 FTM_1583 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001892179.1 1695606 D 441952 CDS YP_001892180.1 187932195 6291107 1696156..1696725 1 NC_010677.1 membrane protein 1696725 6291107 FTM_1584 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001892180.1 1696156 D 441952 CDS YP_001892181.1 187932196 6291091 complement(1696722..1696895) 1 NC_010677.1 hypothetical protein 1696895 6291091 FTM_1585 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892181.1 1696722 R 441952 CDS YP_001892182.1 187932197 6290897 1697025..1698824 1 NC_010677.1 anion ABC transporter permease 1698824 6290897 FTM_1586 Francisella tularensis subsp. mediasiatica FSC147 anion ABC transporter permease YP_001892182.1 1697025 D 441952 CDS YP_001892183.1 187932198 6291584 1698843..1700159 1 NC_010677.1 ABC transporter ATP-binding protein 1700159 6291584 FTM_1587 Francisella tularensis subsp. mediasiatica FSC147 ABC transporter ATP-binding protein YP_001892183.1 1698843 D 441952 CDS YP_001892184.1 187932199 6291495 1701872..1703758 1 NC_010677.1 monovalent cation:proton antiporter 1703758 6291495 FTM_1589 Francisella tularensis subsp. mediasiatica FSC147 monovalent cation:proton antiporter YP_001892184.1 1701872 D 441952 CDS YP_001892185.1 187932200 6291557 1703743..1704282 1 NC_010677.1 carbonic anhydrase/acetyltransferase 1704282 paaY 6291557 paaY Francisella tularensis subsp. mediasiatica FSC147 carbonic anhydrase/acetyltransferase YP_001892185.1 1703743 D 441952 CDS YP_001892186.1 187932201 6291517 1704233..1704877 1 NC_010677.1 outer membrane lipoprotein LolB 1704877 lolB 6291517 lolB Francisella tularensis subsp. mediasiatica FSC147 outer membrane lipoprotein LolB YP_001892186.1 1704233 D 441952 CDS YP_001892187.1 187932202 6291342 1704865..1705692 1 NC_010677.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1705692 ipk 6291342 ipk Francisella tularensis subsp. mediasiatica FSC147 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_001892187.1 1704865 D 441952 CDS YP_001892188.1 187932203 6290932 complement(1707223..1707738) 1 NC_010677.1 cytochrome b561 family protein 1707738 6290932 FTM_1596 Francisella tularensis subsp. mediasiatica FSC147 cytochrome b561 family protein YP_001892188.1 1707223 R 441952 CDS YP_001892189.1 187932204 6290930 complement(1707819..1708814) 1 NC_010677.1 inorganic phosphate transporter (PiT) family protein 1708814 6290930 FTM_1597 Francisella tularensis subsp. mediasiatica FSC147 inorganic phosphate transporter (PiT) family protein YP_001892189.1 1707819 R 441952 CDS YP_001892190.1 187932205 6290905 complement(1708832..1709488) 1 NC_010677.1 hypothetical protein 1709488 6290905 FTM_1598 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892190.1 1708832 R 441952 CDS YP_001892191.1 187932206 6291351 1709725..1711269 1 NC_010677.1 acid phosphatase 1711269 6291351 FTM_1599 Francisella tularensis subsp. mediasiatica FSC147 acid phosphatase YP_001892191.1 1709725 D 441952 CDS YP_001892192.1 187932207 6291518 complement(1715402..1716238) 1 NC_010677.1 universal stress protein 1716238 uspA 6291518 uspA Francisella tularensis subsp. mediasiatica FSC147 universal stress protein YP_001892192.1 1715402 R 441952 CDS YP_001892193.1 187932208 6291541 complement(1716314..1719055) 1 NC_010677.1 DNA/RNA helicase 1719055 6291541 FTM_1605 Francisella tularensis subsp. mediasiatica FSC147 DNA/RNA helicase YP_001892193.1 1716314 R 441952 CDS YP_001892194.1 187932209 6291484 complement(1719039..1719818) 1 NC_010677.1 hypothetical protein 1719818 6291484 FTM_1606 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892194.1 1719039 R 441952 CDS YP_001892195.1 187932210 6291109 complement(1719891..1720454) 1 NC_010677.1 HAD superfamily hydrolase 1720454 6291109 FTM_1607 Francisella tularensis subsp. mediasiatica FSC147 HAD superfamily hydrolase YP_001892195.1 1719891 R 441952 CDS YP_001892196.1 187932211 6291580 complement(1721277..1722149) 1 NC_010677.1 SAM-dependent methyltransferase 1722149 6291580 FTM_1609 Francisella tularensis subsp. mediasiatica FSC147 SAM-dependent methyltransferase YP_001892196.1 1721277 R 441952 CDS YP_001892197.1 187932212 6291047 complement(1722142..1723497) 1 NC_010677.1 UDP-N-acetylmuramate-alanine ligase 1723497 murC 6291047 murC Francisella tularensis subsp. mediasiatica FSC147 UDP-N-acetylmuramate-alanine ligase YP_001892197.1 1722142 R 441952 CDS YP_001892198.1 187932213 6291011 complement(1723564..1724337) 1 NC_010677.1 shikimate 5-dehydrogenase 1724337 6291011 FTM_1611 Francisella tularensis subsp. mediasiatica FSC147 shikimate 5-dehydrogenase YP_001892198.1 1723564 R 441952 CDS YP_001892199.1 187932214 6291348 1724464..1724922 1 NC_010677.1 hypothetical protein 1724922 6291348 FTM_1612 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892199.1 1724464 D 441952 CDS YP_001892200.1 187932215 6291103 1725014..1725148 1 NC_010677.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1725148 rpmH 6291103 rpmH Francisella tularensis subsp. mediasiatica FSC147 50S ribosomal protein L34 YP_001892200.1 1725014 D 441952 CDS YP_001892201.1 187932216 6291240 1725138..1725491 1 NC_010677.1 ribonuclease P protein component 1725491 rnpA 6291240 rnpA Francisella tularensis subsp. mediasiatica FSC147 ribonuclease P protein component YP_001892201.1 1725138 D 441952 CDS YP_001892202.1 187932217 6291435 1725467..1725715 1 NC_010677.1 hypothetical protein 1725715 6291435 FTM_1615 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892202.1 1725467 D 441952 CDS YP_001892203.1 187932218 6291680 1725724..1727379 1 NC_010677.1 membrane protein 1727379 6291680 FTM_1616 Francisella tularensis subsp. mediasiatica FSC147 membrane protein YP_001892203.1 1725724 D 441952 CDS YP_001892204.1 187932219 6291539 1727386..1728285 1 NC_010677.1 LPS fatty acid acyltransferase 1728285 6291539 FTM_1617 Francisella tularensis subsp. mediasiatica FSC147 LPS fatty acid acyltransferase YP_001892204.1 1727386 D 441952 CDS YP_001892205.1 187932220 6291427 1728346..1729269 1 NC_010677.1 LPS fatty acid acyltransferase 1729269 6291427 FTM_1618 Francisella tularensis subsp. mediasiatica FSC147 LPS fatty acid acyltransferase YP_001892205.1 1728346 D 441952 CDS YP_001892206.1 187932221 6291311 1729281..1729688 1 NC_010677.1 Type IV pili, pilus assembly protein 1729688 pilE 6291311 pilE Francisella tularensis subsp. mediasiatica FSC147 Type IV pili, pilus assembly protein YP_001892206.1 1729281 D 441952 CDS YP_001892207.1 187932222 6291621 1729728..1730297 1 NC_010677.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 1730297 efp 6291621 efp Francisella tularensis subsp. mediasiatica FSC147 elongation factor P YP_001892207.1 1729728 D 441952 CDS YP_001892208.1 187932223 6291428 1730300..1730836 1 NC_010677.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 1730836 orn 6291428 orn Francisella tularensis subsp. mediasiatica FSC147 oligoribonuclease YP_001892208.1 1730300 D 441952 CDS YP_001892209.1 187932224 6291271 complement(1734512..1737145) 1 NC_010677.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 1737145 ppdK 6291271 ppdK Francisella tularensis subsp. mediasiatica FSC147 pyruvate phosphate dikinase YP_001892209.1 1734512 R 441952 CDS YP_001892210.1 187932225 6291269 complement(1737972..1740215) 1 NC_010677.1 ferrous iron transport protein B 1740215 feoB 6291269 feoB Francisella tularensis subsp. mediasiatica FSC147 ferrous iron transport protein B YP_001892210.1 1737972 R 441952 CDS YP_001892211.1 187932226 6291364 complement(1741641..1743794) 1 NC_010677.1 primosomal protein N' 1743794 priA 6291364 priA Francisella tularensis subsp. mediasiatica FSC147 primosomal protein N' YP_001892211.1 1741641 R 441952 CDS YP_001892212.1 187932227 6291386 complement(1743791..1744366) 1 NC_010677.1 nicotinamide ribonucleoside (NR) uptake permease (PnuC) family protein 1744366 6291386 FTM_1629 Francisella tularensis subsp. mediasiatica FSC147 nicotinamide ribonucleoside (NR) uptake permease (PnuC) family protein YP_001892212.1 1743791 R 441952 CDS YP_001892213.1 187932228 6291305 complement(1744385..1745572) 1 NC_010677.1 tRNA processing ribonuclease BN 1745572 rbn 6291305 rbn Francisella tularensis subsp. mediasiatica FSC147 tRNA processing ribonuclease BN YP_001892213.1 1744385 R 441952 CDS YP_001892214.1 187932229 6291299 1745579..1746175 1 NC_010677.1 trp repressor binding protein 1746175 wrbA 6291299 wrbA Francisella tularensis subsp. mediasiatica FSC147 trp repressor binding protein YP_001892214.1 1745579 D 441952 CDS YP_001892215.1 187932230 6291032 1746186..1746650 1 NC_010677.1 outer membrane lipoprotein 1746650 6291032 FTM_1632 Francisella tularensis subsp. mediasiatica FSC147 outer membrane lipoprotein YP_001892215.1 1746186 D 441952 CDS YP_001892216.1 187932231 6291027 1746771..1747994 1 NC_010677.1 major facilitator superfamily (MFS) transport protein 1747994 6291027 FTM_1633 Francisella tularensis subsp. mediasiatica FSC147 major facilitator superfamily (MFS) transport protein YP_001892216.1 1746771 D 441952 CDS YP_001892217.1 187932232 6291135 1748069..1748986 1 NC_010677.1 manganese/Zinc/Iron chelate uptake transporter family protein 1748986 6291135 FTM_1634 Francisella tularensis subsp. mediasiatica FSC147 manganese/Zinc/Iron chelate uptake transporter family protein YP_001892217.1 1748069 D 441952 CDS YP_001892218.1 187932233 6291589 1748987..1749664 1 NC_010677.1 ATP-binding cassette (ABC) superfamily protein 1749664 6291589 FTM_1635 Francisella tularensis subsp. mediasiatica FSC147 ATP-binding cassette (ABC) superfamily protein YP_001892218.1 1748987 D 441952 CDS YP_001892219.1 187932234 6291548 1749606..1750448 1 NC_010677.1 manganese/zinc/iron chelate uptake transporter (MZT) family protein 1750448 6291548 FTM_1636 Francisella tularensis subsp. mediasiatica FSC147 manganese/zinc/iron chelate uptake transporter (MZT) family protein YP_001892219.1 1749606 D 441952 CDS YP_001892220.1 187932235 6291362 complement(1751270..1751803) 1 NC_010677.1 hypoxanthine-guanine phosphoribosyltransferase 1751803 hpt 6291362 hpt Francisella tularensis subsp. mediasiatica FSC147 hypoxanthine-guanine phosphoribosyltransferase YP_001892220.1 1751270 R 441952 CDS YP_001892221.1 187932236 6291343 complement(1751807..1753093) 1 NC_010677.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1753093 purA 6291343 purA Francisella tularensis subsp. mediasiatica FSC147 adenylosuccinate synthetase YP_001892221.1 1751807 R 441952 CDS YP_001892222.1 187932237 6291023 1753270..1754817 1 NC_010677.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1754817 purH 6291023 purH Francisella tularensis subsp. mediasiatica FSC147 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001892222.1 1753270 D 441952 CDS YP_001892223.1 187932238 6291270 complement(1758946..1759464) 1 NC_010677.1 outer membrane lipoprotein blc 1759464 blc 6291270 blc Francisella tularensis subsp. mediasiatica FSC147 outer membrane lipoprotein blc YP_001892223.1 1758946 R 441952 CDS YP_001892224.1 187932239 6291125 1759550..1760527 1 NC_010677.1 DNA polymerase III subunit delta 1760527 holA 6291125 holA Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase III subunit delta YP_001892224.1 1759550 D 441952 CDS YP_001892225.1 187932240 6290781 1760647..1761684 1 NC_010677.1 glutamine synthetase 1761684 glnA 6290781 glnA Francisella tularensis subsp. mediasiatica FSC147 glutamine synthetase YP_001892225.1 1760647 D 441952 CDS YP_001892226.1 187932241 6291361 1764285..1764827 1 NC_010677.1 hypothetical protein 1764827 6291361 FTM_1648 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892226.1 1764285 D 441952 CDS YP_001892227.1 187932242 6291121 complement(1765212..1766942) 1 NC_010677.1 lysyl-tRNA synthetase 1766942 lysU 6291121 lysU Francisella tularensis subsp. mediasiatica FSC147 lysyl-tRNA synthetase YP_001892227.1 1765212 R 441952 CDS YP_001892228.1 187932243 6291286 complement(1767075..1768052) 1 NC_010677.1 peptide chain release factor 2 1768052 prfB 6291286 prfB Francisella tularensis subsp. mediasiatica FSC147 peptide chain release factor 2 YP_001892228.1 1767075 R 441952 CDS YP_001892229.1 187932244 6291061 1768325..1769965 1 NC_010677.1 DNA polymerase III subunit gamma/tau 1769965 dnaX 6291061 dnaX Francisella tularensis subsp. mediasiatica FSC147 DNA polymerase III subunit gamma/tau YP_001892229.1 1768325 D 441952 CDS YP_001892230.1 187932245 6290998 complement(1769980..1770837) 1 NC_010677.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1770837 lpxC 6290998 lpxC Francisella tularensis subsp. mediasiatica FSC147 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_001892230.1 1769980 R 441952 CDS YP_001892231.1 187932246 6290950 complement(1770863..1772008) 1 NC_010677.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1772008 ftsZ 6290950 ftsZ Francisella tularensis subsp. mediasiatica FSC147 cell division protein FtsZ YP_001892231.1 1770863 R 441952 CDS YP_001892232.1 187932247 6291130 complement(1772052..1773314) 1 NC_010677.1 cell division protein FtsA 1773314 ftsA 6291130 ftsA Francisella tularensis subsp. mediasiatica FSC147 cell division protein FtsA YP_001892232.1 1772052 R 441952 CDS YP_001892233.1 187932248 6291634 complement(1773416..1774099) 1 NC_010677.1 cell division protein FtsQ 1774099 ftsQ 6291634 ftsQ Francisella tularensis subsp. mediasiatica FSC147 cell division protein FtsQ YP_001892233.1 1773416 R 441952 CDS YP_001892234.1 187932249 6290978 complement(1774991..1775452) 1 NC_010677.1 zinc-binding protein 1775452 6290978 FTM_1657 Francisella tularensis subsp. mediasiatica FSC147 zinc-binding protein YP_001892234.1 1774991 R 441952 CDS YP_001892235.1 187932250 6291096 1775600..1777270 1 NC_010677.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1777270 rpsA 6291096 rpsA Francisella tularensis subsp. mediasiatica FSC147 30S ribosomal protein S1 YP_001892235.1 1775600 D 441952 CDS YP_001892236.1 187932251 6291105 1777387..1777929 1 NC_010677.1 Sua5/YciO/YrdC family protein 1777929 6291105 FTM_1659 Francisella tularensis subsp. mediasiatica FSC147 Sua5/YciO/YrdC family protein YP_001892236.1 1777387 D 441952 CDS YP_001892237.1 187932252 6291319 1778027..1778563 1 NC_010677.1 hypothetical protein 1778563 6291319 FTM_1660 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892237.1 1778027 D 441952 CDS YP_001892238.1 187932253 6291316 complement(1778960..1779850) 1 NC_010677.1 putative acyltransferase 1779850 plsC 6291316 plsC Francisella tularensis subsp. mediasiatica FSC147 putative acyltransferase YP_001892238.1 1778960 R 441952 CDS YP_001892239.1 187932254 6291353 1782121..1783590 1 NC_010677.1 glutathione synthase/ribosomal protein S6 modification protein 1783590 rimK 6291353 rimK Francisella tularensis subsp. mediasiatica FSC147 glutathione synthase/ribosomal protein S6 modification protein YP_001892239.1 1782121 D 441952 CDS YP_001892240.1 187932255 6291262 1785177..1785959 1 NC_010677.1 nitrate/sulfonate/bicarbonate ABC transporter ATPase 1785959 6291262 FTM_1666 Francisella tularensis subsp. mediasiatica FSC147 nitrate/sulfonate/bicarbonate ABC transporter ATPase YP_001892240.1 1785177 D 441952 CDS YP_001892241.1 187932256 6291260 complement(1785953..1786522) 1 NC_010677.1 YggT family membrane protein 1786522 6291260 FTM_1667 Francisella tularensis subsp. mediasiatica FSC147 YggT family membrane protein YP_001892241.1 1785953 R 441952 CDS YP_001892242.1 187932257 6291313 complement(1789187..1793059) 1 NC_010677.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1793059 purL 6291313 purL Francisella tularensis subsp. mediasiatica FSC147 phosphoribosylformylglycinamidine synthase YP_001892242.1 1789187 R 441952 CDS YP_001892243.1 187932258 6291309 complement(1793059..1794549) 1 NC_010677.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1794549 purF 6291309 purF Francisella tularensis subsp. mediasiatica FSC147 amidophosphoribosyltransferase YP_001892243.1 1793059 R 441952 CDS YP_001892244.1 187932259 6291709 complement(1795999..1796640) 1 NC_010677.1 phosphopantetheinyl transferase 1796640 6291709 FTM_1674 Francisella tularensis subsp. mediasiatica FSC147 phosphopantetheinyl transferase YP_001892244.1 1795999 R 441952 CDS YP_001892245.1 187932260 6290892 complement(1796649..1798178) 1 NC_010677.1 outer membrane efflux protein, TolC 1798178 tolC 6290892 tolC Francisella tularensis subsp. mediasiatica FSC147 outer membrane efflux protein, TolC YP_001892245.1 1796649 R 441952 CDS YP_001892246.1 187932261 6291088 complement(1798187..1798807) 1 NC_010677.1 protein-L-isoaspartate O-methyltransferase 1798807 pcm 6291088 pcm Francisella tularensis subsp. mediasiatica FSC147 protein-L-isoaspartate O-methyltransferase YP_001892246.1 1798187 R 441952 CDS YP_001892247.1 187932262 6291094 1799127..1800458 1 NC_010677.1 peptidase U32 family 1800458 6291094 FTM_1677 Francisella tularensis subsp. mediasiatica FSC147 peptidase U32 family YP_001892247.1 1799127 D 441952 CDS YP_001892248.1 187932263 6291227 complement(1800499..1801680) 1 NC_010677.1 drug:H+ antiporter-1 (DHA1) family protein 1801680 6291227 FTM_1678 Francisella tularensis subsp. mediasiatica FSC147 drug:H+ antiporter-1 (DHA1) family protein YP_001892248.1 1800499 R 441952 CDS YP_001892249.1 187932264 6290874 1801855..1803282 1 NC_010677.1 Na+:H+ antiporter, NhaD 1803282 nhaD 6290874 nhaD Francisella tularensis subsp. mediasiatica FSC147 Na+:H+ antiporter, NhaD YP_001892249.1 1801855 D 441952 CDS YP_001892250.1 187932265 6291626 complement(1804935..1806809) 1 NC_010677.1 amino acid-polyamine-organocation (APC) superfamily protein 1806809 6291626 FTM_1681 Francisella tularensis subsp. mediasiatica FSC147 amino acid-polyamine-organocation (APC) superfamily protein YP_001892250.1 1804935 R 441952 CDS YP_001892251.1 187932266 6291502 complement(1806816..1807820) 1 NC_010677.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1807820 obgE 6291502 obgE Francisella tularensis subsp. mediasiatica FSC147 GTPase ObgE YP_001892251.1 1806816 R 441952 CDS YP_001892252.1 187932267 6291349 complement(1807896..1809092) 1 NC_010677.1 tyrosine permease 1809092 tyrP 6291349 tyrP Francisella tularensis subsp. mediasiatica FSC147 tyrosine permease YP_001892252.1 1807896 R 441952 CDS YP_001892253.1 187932268 6291697 complement(1809539..1810183) 1 NC_010677.1 outer membrane associated protein 1810183 6291697 FTM_1684 Francisella tularensis subsp. mediasiatica FSC147 outer membrane associated protein YP_001892253.1 1809539 R 441952 CDS YP_001892254.1 187932269 6291644 complement(1810963..1813644) 1 NC_010677.1 two component regulator, sensor histidine kinase KdpD 1813644 kdpD 6291644 kdpD Francisella tularensis subsp. mediasiatica FSC147 two component regulator, sensor histidine kinase KdpD YP_001892254.1 1810963 R 441952 CDS YP_001892255.1 187932270 6291524 complement(1813748..1814302) 1 NC_010677.1 potassium-transporting ATPase C chain 1814302 kdpC 6291524 kdpC Francisella tularensis subsp. mediasiatica FSC147 potassium-transporting ATPase C chain YP_001892255.1 1813748 R 441952 CDS YP_001892256.1 187932271 6291300 complement(1814319..1816358) 1 NC_010677.1 potassium-transporting ATPase B chain 1816358 kdpB 6291300 kdpB Francisella tularensis subsp. mediasiatica FSC147 potassium-transporting ATPase B chain YP_001892256.1 1814319 R 441952 CDS YP_001892257.1 187932272 6291298 complement(1816368..1818089) 1 NC_010677.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1818089 kdpA 6291298 kdpA Francisella tularensis subsp. mediasiatica FSC147 potassium-transporting ATPase subunit A YP_001892257.1 1816368 R 441952 CDS YP_001892258.1 187932273 6291153 1825027..1827489 1 NC_010677.1 hypothetical protein 1827489 pdpA2 6291153 pdpA2 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892258.1 1825027 D 441952 CDS YP_001892259.1 187932274 6291113 1827494..1830775 1 NC_010677.1 hypothetical protein 1830775 pdpB2 6291113 pdpB2 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892259.1 1827494 D 441952 CDS YP_001892260.1 187932275 6291410 1830765..1831142 1 NC_010677.1 lipoprotein 1831142 6291410 FTM_1698 Francisella tularensis subsp. mediasiatica FSC147 lipoprotein YP_001892260.1 1830765 D 441952 CDS YP_001892261.1 187932276 6291408 1831155..1831649 1 NC_010677.1 hypothetical protein 1831649 6291408 FTM_1699 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892261.1 1831155 D 441952 CDS YP_001892262.1 187932277 6291074 1831654..1833318 1 NC_010677.1 hypothetical protein 1833318 6291074 FTM_1700 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892262.1 1831654 D 441952 CDS YP_001892263.1 187932278 6291223 1833386..1833907 1 NC_010677.1 hypothetical protein 1833907 6291223 FTM_1701 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892263.1 1833386 D 441952 CDS YP_001892264.1 187932279 6290977 1833920..1835350 1 NC_010677.1 hypothetical protein 1835350 6290977 FTM_1702 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892264.1 1833920 D 441952 CDS YP_001892265.1 187932280 6291383 1835363..1835980 1 NC_010677.1 hypothetical protein 1835980 6291383 FTM_1703 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892265.1 1835363 D 441952 CDS YP_001892266.1 187932281 6291370 1836002..1837153 1 NC_010677.1 hypothetical protein 1837153 6291370 FTM_1704 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892266.1 1836002 D 441952 CDS YP_001892267.1 187932282 6291400 1837119..1837892 1 NC_010677.1 hypothetical protein 1837892 6291400 FTM_1705 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892267.1 1837119 D 441952 CDS YP_001892268.1 187932283 6291396 1837932..1841918 1 NC_010677.1 PdpC 1841918 pdpC2 6291396 pdpC2 Francisella tularensis subsp. mediasiatica FSC147 PdpC YP_001892268.1 1837932 D 441952 CDS YP_001892269.1 187932284 6289989 1841936..1842511 1 NC_010677.1 hypothetical protein 1842511 6289989 FTM_1707 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892269.1 1841936 D 441952 CDS YP_001892270.1 187932285 6289998 complement(1842518..1843714) 1 NC_010677.1 intracellular growth locus protein D 1843714 iglD2 6289998 iglD2 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus protein D YP_001892270.1 1842518 R 441952 CDS YP_001892271.1 187932286 6290007 complement(1843735..1844364) 1 NC_010677.1 intracellular growth locus protein C 1844364 iglC2 6290007 iglC2 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus protein C YP_001892271.1 1843735 R 441952 CDS YP_001892272.1 187932287 6290009 complement(1844381..1845901) 1 NC_010677.1 intracellular growth locus protein B 1845901 iglB2 6290009 iglB2 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus protein B YP_001892272.1 1844381 R 441952 CDS YP_001892273.1 187932288 6290616 complement(1845915..1846469) 1 NC_010677.1 intracellular growth locus protein A 1846469 iglA2 6290616 iglA2 Francisella tularensis subsp. mediasiatica FSC147 intracellular growth locus protein A YP_001892273.1 1845915 R 441952 CDS YP_001892274.1 187932289 6290037 complement(1846550..1850281) 1 NC_010677.1 hypothetical protein 1850281 pdpD2 6290037 pdpD2 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892274.1 1846550 R 441952 CDS YP_001892275.1 187932290 6290057 1853681..1854889 1 NC_010677.1 metabolite:H+ symporter (MHS) family protein 1854889 6290057 FTM_1716 Francisella tularensis subsp. mediasiatica FSC147 metabolite:H+ symporter (MHS) family protein YP_001892275.1 1853681 D 441952 CDS YP_001892276.1 187932291 6290066 1855064..1856842 1 NC_010677.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1856842 aspS 6290066 aspS Francisella tularensis subsp. mediasiatica FSC147 aspartyl-tRNA synthetase YP_001892276.1 1855064 D 441952 CDS YP_001892277.1 187932292 6290106 complement(1858984..1861080) 1 NC_010677.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 1861080 pta 6290106 pta Francisella tularensis subsp. mediasiatica FSC147 phosphate acetyltransferase YP_001892277.1 1858984 R 441952 CDS YP_001892278.1 187932293 6290111 complement(1861090..1862244) 1 NC_010677.1 propionate kinase 2 / acetate kinase A 1862244 ackA 6290111 ackA Francisella tularensis subsp. mediasiatica FSC147 propionate kinase 2 / acetate kinase A YP_001892278.1 1861090 R 441952 CDS YP_001892279.1 187932294 6290113 complement(1862350..1862826) 1 NC_010677.1 single-strand DNA binding protein 1862826 ssb 6290113 ssb Francisella tularensis subsp. mediasiatica FSC147 single-strand DNA binding protein YP_001892279.1 1862350 R 441952 CDS YP_001892280.1 187932295 6290120 complement(1863000..1863452) 1 NC_010677.1 regulatory protein RecX, inhibitor of RecA 1863452 recX 6290120 recX Francisella tularensis subsp. mediasiatica FSC147 regulatory protein RecX, inhibitor of RecA YP_001892280.1 1863000 R 441952 CDS YP_001892281.1 187932296 6290126 complement(1863439..1864518) 1 NC_010677.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1864518 recA 6290126 recA Francisella tularensis subsp. mediasiatica FSC147 recombinase A YP_001892281.1 1863439 R 441952 CDS YP_001892282.1 187932297 6290133 complement(1864540..1864989) 1 NC_010677.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1864989 secB1 6290133 secB1 Francisella tularensis subsp. mediasiatica FSC147 preprotein translocase subunit SecB YP_001892282.1 1864540 R 441952 CDS YP_001892283.1 187932298 6290144 complement(1865016..1865438) 1 NC_010677.1 rhodanese-related sulfurtransferase 1865438 6290144 FTM_1726 Francisella tularensis subsp. mediasiatica FSC147 rhodanese-related sulfurtransferase YP_001892283.1 1865016 R 441952 CDS YP_001892284.1 187932299 6290146 complement(1865574..1866113) 1 NC_010677.1 outer membrane protein 1866113 6290146 FTM_1727 Francisella tularensis subsp. mediasiatica FSC147 outer membrane protein YP_001892284.1 1865574 R 441952 CDS YP_001892285.1 187932300 6290163 complement(1866203..1867126) 1 NC_010677.1 serine peptidase, S49 family 1867126 6290163 FTM_1728 Francisella tularensis subsp. mediasiatica FSC147 serine peptidase, S49 family YP_001892285.1 1866203 R 441952 CDS YP_001892286.1 187932301 6290170 1867657..1869354 1 NC_010677.1 indolepyruvate decarboxylase 1869354 idpC 6290170 idpC Francisella tularensis subsp. mediasiatica FSC147 indolepyruvate decarboxylase YP_001892286.1 1867657 D 441952 CDS YP_001892287.1 187932302 6290198 complement(1871639..1873318) 1 NC_010677.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 1873318 6290198 FTM_1733 Francisella tularensis subsp. mediasiatica FSC147 putative ABC transporter ATP-binding protein YP_001892287.1 1871639 R 441952 CDS YP_001892288.1 187932303 6290201 1873531..1874772 1 NC_010677.1 metabolite:H+ symporter (MHS) family protein 1874772 6290201 FTM_1734 Francisella tularensis subsp. mediasiatica FSC147 metabolite:H+ symporter (MHS) family protein YP_001892288.1 1873531 D 441952 CDS YP_001892289.1 187932304 6290202 complement(1875161..1875286) 1 NC_010677.1 hypothetical protein 1875286 6290202 FTM_1735 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892289.1 1875161 R 441952 CDS YP_001892290.1 187932305 6290203 1875332..1876312 1 NC_010677.1 hypothetical protein 1876312 6290203 FTM_1736 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892290.1 1875332 D 441952 CDS YP_001892291.1 187932306 6290209 1877038..1877958 1 NC_010677.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 1877958 6290209 FTM_1738 Francisella tularensis subsp. mediasiatica FSC147 chromosome replication initiation inhibitor protein YP_001892291.1 1877038 D 441952 CDS YP_001892292.1 187932307 6290216 1879479..1879799 1 NC_010677.1 hypothetical protein 1879799 6290216 FTM_1741 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892292.1 1879479 D 441952 CDS YP_001892293.1 187932308 6290217 complement(1880930..1883506) 1 NC_010677.1 aminopeptidase N 1883506 pepN 6290217 pepN Francisella tularensis subsp. mediasiatica FSC147 aminopeptidase N YP_001892293.1 1880930 R 441952 CDS YP_001892294.1 187932309 6290221 1883708..1884136 1 NC_010677.1 heat shock protein, HSP20 family 1884136 6290221 FTM_1743 Francisella tularensis subsp. mediasiatica FSC147 heat shock protein, HSP20 family YP_001892294.1 1883708 D 441952 CDS YP_001892295.1 187932310 6290224 complement(1884133..1885494) 1 NC_010677.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1885494 trpC 6290224 trpC Francisella tularensis subsp. mediasiatica FSC147 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_001892295.1 1884133 R 441952 CDS YP_001892296.1 187932311 6290231 complement(1885586..1885999) 1 NC_010677.1 hypothetical protein 1885999 6290231 FTM_1745 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892296.1 1885586 R 441952 CDS YP_001892297.1 187932312 6290243 complement(1887137..1887478) 1 NC_010677.1 hypothetical protein 1887478 6290243 FTM_1748 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892297.1 1887137 R 441952 CDS YP_001892298.1 187932313 6290246 complement(1887547..1887987) 1 NC_010677.1 hypothetical protein 1887987 6290246 FTM_1749 Francisella tularensis subsp. mediasiatica FSC147 hypothetical protein YP_001892298.1 1887547 R 441952 CDS YP_001892299.1 187932314 6290249 complement(1888049..1889062) 1 NC_010677.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1889062 trpD 6290249 trpD Francisella tularensis subsp. mediasiatica FSC147 anthranilate phosphoribosyltransferase YP_001892299.1 1888049 R 441952 CDS YP_001892300.1 187932315 6290253 complement(1889059..1889637) 1 NC_010677.1 anthranilate synthase component II 1889637 trpG 6290253 trpG Francisella tularensis subsp. mediasiatica FSC147 anthranilate synthase component II YP_001892300.1 1889059 R 441952 CDS YP_001892301.1 187932316 6290256 complement(1889641..1891185) 1 NC_010677.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1891185 trpE 6290256 trpE Francisella tularensis subsp. mediasiatica FSC147 anthranilate synthase component I YP_001892301.1 1889641 R 441952 CDS YP_001892302.1 187932317 6290258 complement(1891194..1891481) 1 NC_010677.1 trp operon repressor 1891481 trpR 6290258 trpR Francisella tularensis subsp. mediasiatica FSC147 trp operon repressor YP_001892302.1 1891194 R 441952 CDS YP_001892303.1 187932318 6290269 complement(1891956..1893452) 1 NC_010677.1 ribonuclease G 1893452 rng 6290269 rng Francisella tularensis subsp. mediasiatica FSC147 ribonuclease G YP_001892303.1 1891956 R 441952 CDS